Your Vote Counts! MOONLAKE IMMUNOTHERAPEUTICS DORFSTRASSE 29 ZUG, SWITZERLAND 6300 MOONLAKE IMMUNOTHERAPEUTICS 2023 Annual General Meeting of Shareholders Vote by June 6, 2023 11:59 PM ET You invested in MOONLAKE IMMUNOTHERAPEUTICS and it’s time to vote! You have the right to vote on proposals being presented at the Annual General Meeting of Shareholders. This is an important notice regarding the availability of proxy materials for the shareholder meeting to be held on June 7, 2023. Get informed before you vote View the Notice, Proxy Statement and Annual Report online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 24, 2023. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Vote in Person at the Meeting* June 7, 2023 8:00 a.m. Eastern Time At the offices of Gibson, Dunn & Crutcher LLP located at 200 Park Avenue New York, New York 10166 *Please check the meeting materials for any special requirements for meeting attendance. At the meeting, you will need to request a ballot to vote these shares. Smartphone users Point your camera here and vote without entering a control number For complete information and to vote, visit www.ProxyVote.com Control # V08953-P89084 V1.2