The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 6,218 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
| APELLIS PHARMACEUTICALS INC | COM | 03753U106 | 13,156 | 230,000 | SH | DFND | 1 | 230,000 | 0 | 0 | |
| APTOSE BIOSCIENCES INC | COM NEW | 03835T200 | 6,172 | 1,409,150 | SH | DFND | 1 | 1,409,150 | 0 | 0 | |
| ARVINAS INC | COM | 04335A105 | 8,493 | 100,000 | SH | DFND | 1 | 100,000 | 0 | 0 | |
| ATEA PHARMACEUTICALS INC | COM | 04683R106 | 42,477 | 1,016,688 | SH | DFND | 1 | 1,016,688 | 0 | 0 | |
| AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 11,867 | 858,032 | SH | DFND | 1 | 858,032 | 0 | 0 | |
| CASTLE BIOSCIENCES INC | COM | 14843C105 | 14,102 | 210,000 | SH | DFND | 1 | 210,000 | 0 | 0 | |
| CEREVEL THERAPEUTICS HLDNG I | COM | 15678U128 | 29,304 | 1,767,440 | SH | DFND | 1 | 1,767,440 | 0 | 0 | |
| CHINOOK THERAPEUTICS INC | COM | 16961L106 | 3,166 | 199,600 | SH | DFND | 1 | 199,600 | 0 | 0 | |
| COGENT BIOSCIENCES INC | COM | 19240Q201 | 18,222 | 1,622,591 | SH | DFND | 1 | 1,622,591 | 0 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 933 | 78,185 | SH | DFND | 1 | 78,185 | 0 | 0 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 23,642 | 260,000 | SH | DFND | 1 | 260,000 | 0 | 0 | |
| FREELINE THERAPEUTICS HLDGS | SPONSORED ADS | 35655L107 | 7,761 | 425,000 | SH | DFND | 1 | 425,000 | 0 | 0 | |
| INTELLIA THERAPEUTICS INC | COM | 45826J105 | 12,240 | 225,000 | SH | DFND | 1 | 225,000 | 0 | 0 | |
| IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 16,704 | 360,000 | SH | DFND | 1 | 360,000 | 0 | 0 | |
| ITAMAR MED LTD | SPONSORED ADS | 465437101 | 9,969 | 501,964 | SH | DFND | 1 | 501,964 | 0 | 0 | |
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 10,917 | 322,794 | SH | DFND | 1 | 322,794 | 0 | 0 | |
| MEDAVAIL HOLDINGS INC | COM | 58406B103 | 43,958 | 2,920,780 | SH | DFND | 1 | 2,920,780 | 0 | 0 | |
| NANOSTRING TECHNOLOGIES INC | COM | 63009R109 | 620 | 9,277 | SH | DFND | 1 | 9,277 | 0 | 0 | |
| NATERA INC | COM | 632307104 | 18,710 | 188,000 | SH | DFND | 1 | 188,000 | 0 | 0 | |
| ONCTERNAL THERAPEUTICS INC | COM | 68236P107 | 1,470 | 300,000 | SH | DFND | 1 | 300,000 | 0 | 0 | |
| ORCHARD THERAPEUTICS PLC | ADS | 68570P101 | 2,365 | 547,427 | SH | DFND | 1 | 547,427 | 0 | 0 | |
| ORIC PHARMACEUTICALS INC | COM | 68622P109 | 13,982 | 413,061 | SH | DFND | 1 | 413,061 | 0 | 0 | |
| PULMONX CORP | COM | 745848101 | 13,743 | 199,122 | SH | DFND | 1 | 199,122 | 0 | 0 | |
| REPLIGEN CORP | COM | 759916109 | 15,809 | 82,500 | SH | DFND | 1 | 82,500 | 0 | 0 | |
| SAREPTA THERAPEUTICS INC | COM | 803607900 | 40,679 | 238,600 | SH | Call | DFND | 1 | 238,600 | 0 | 0 |
| SILVERBACK THERAPEUTICS INC | COM | 82835W108 | 5,958 | 128,572 | SH | DFND | 1 | 128,572 | 0 | 0 | |
| SPDR SER TR | S&P BIOTECH | 78464A950 | 154,858 | 1,100,000 | SH | Put | DFND | 1 | 1,100,000 | 0 | 0 |
| SYROS PHARMACEUTICALS INC | COM | 87184Q107 | 28,671 | 2,642,500 | SH | DFND | 1 | 2,642,500 | 0 | 0 | |
| VIR BIOTECHNOLOGY INC | COM | 92764N102 | 7,365 | 275,000 | SH | DFND | 1 | 275,000 | 0 | 0 | |