Guggenheim Defined Portfolios, Series 2100 S-6/A Registration of securities by unit investment trust (amended)

 EXHIBIT 4.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts-Independent Registered Public Accounting Firm” and to the use of our report dated February 24, 2021 in the Amendment No. 1 to the Registration Statement (File No. 333-251592) and related Prospectus of Guggenheim Defined Portfolios, Series 2100.

/s/ Grant Thornton LLP

GRANT THORNTON LLP

Chicago, Illinois

February 24, 2021