Document and Entity Information
Document and Entity Information - USD ($) $ in Millions | 12 Months Ended | ||
Dec. 31, 2021 | Mar. 22, 2022 | Jun. 30, 2021 | |
Document Information [Line Items] | |||
Document Type | 10-K | ||
Amendment Flag | false | ||
Entity Voluntary Filers | No | ||
Entity Well-known Seasoned Issuer | No | ||
Document Period End Date | Dec. 31, 2021 | ||
Document Fiscal Year Focus | 2021 | ||
Document Fiscal Period Focus | FY | ||
Trading Symbol | VERA | ||
Entity Registrant Name | Vera Therapeutics, Inc. | ||
Entity Central Index Key | 0001831828 | ||
Current Fiscal Year End Date | --12-31 | ||
Entity Current Reporting Status | Yes | ||
Entity Filer Category | Non-accelerated Filer | ||
Entity Interactive Data Current | Yes | ||
Entity Shell Company | false | ||
Entity Small Business | true | ||
Entity Emerging Growth Company | true | ||
Entity Ex Transition Period | false | ||
Title of 12(b) Security | Class A common stock, $0.001 par value per share | ||
Security Exchange Name | NASDAQ | ||
Entity File Number | 001-40407 | ||
Entity Incorporation, State or Country Code | DE | ||
Entity Tax Identification Number | 81-2711119 | ||
Document Annual Report | true | ||
Document Transition Report | false | ||
Entity Address, Address Line One | 8000 Marina Boulevard | ||
Entity Address, Address Line Two | Suite 120 | ||
Entity Address, City or Town | Brisbane | ||
Entity Address, State or Province | CA | ||
Entity Address, Postal Zip Code | 94005 | ||
City Area Code | 650 | ||
Local Phone Number | 770-0077 | ||
Entity Public Float | $ 94.4 | ||
Documents Incorporated by Reference | DOCUMENTS INCORPORATED BY REFERENCE Portions of the Registrant's definitive proxy statement for its 2022 Annual Meeting of Stockholders, which the Registrant intends to file pursuant to Regulation 14A with the Securities and Exchange Commission not later than 120 days after the Registrant's fiscal year ended December 31, 2021, are incorporated by reference into Part III of this Annual Report on Form 10-K. | ||
ICFR Auditor Attestation Flag | false | ||
Auditor Location | San Francisco, California | ||
Auditor Name | KPMG LLP | ||
Auditor Firm ID | 185 | ||
Common Class A | |||
Document Information [Line Items] | |||
Entity Common Stock, Shares Outstanding | 26,743,289 | ||
Common Class B [Member] | |||
Document Information [Line Items] | |||
Entity Common Stock, Shares Outstanding | 309,238 |
Balance Sheets
Balance Sheets - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Current assets: | ||
Cash and cash equivalents | $ 79,674 | $ 53,654 |
Restricted cash, current | 0 | 50 |
Prepaid expenses and other current assets, current | 2,863 | 557 |
Total current assets | 82,537 | 54,261 |
Restricted cash, noncurrent | 293 | 293 |
Prepaid expenses and other current assets, noncurrent | 51 | 0 |
Non-marketable equity securities | 867 | 0 |
Total assets | 83,748 | 54,554 |
Current liabilities: | ||
Accounts payable | 1,385 | 909 |
Restructuring liability, current | 377 | 962 |
Accrued expenses and other current liabilities | 5,928 | 535 |
Total current liabilities | 7,690 | 2,406 |
Long-term Debt | 4,923 | 0 |
Restructuring liability, noncurrent | 1,257 | 1,634 |
Accrued and other noncurrent liabilities | 286 | 286 |
Total liabilities | 14,156 | 4,326 |
Commitments and contingencies (Note 14) | ||
Redeemable convertible preferred stock, $0.001 par value; 0 and 182,772,372 shares authorized, issued and outstanding as of December 31, 2021 and December 31, 2020, respectively | 0 | 139,576 |
Stockholders’ equity (deficit) | ||
Preferred stock, $0.001 par value; 10,000,000 and 0 shares authorized as of December 31, 2021 and 2020, respectively; no shares issued and outstanding as of December 31, 2021 and December 31, 2020 | 0 | 0 |
Additional paid-in capital | 193,627 | 2,099 |
Accumulated deficit | (124,056) | (91,447) |
Total stockholders’ equity (deficit) | 69,592 | (89,348) |
Total liabilities, redeemable convertible preferred stock, and stockholders’ equity (deficit) | 83,748 | 54,554 |
Common Class A [Member] | ||
Stockholders’ equity (deficit) | ||
Common Stock | 21 | 0 |
Common Class B Non Voting [Member] | ||
Stockholders’ equity (deficit) | ||
Common Stock | $ 0 | $ 0 |
Balance Sheets (Parenthetical)
Balance Sheets (Parenthetical) - $ / shares | Dec. 31, 2021 | Dec. 31, 2020 |
Temporary equity par or stated value per share | $ 0.001 | $ 0.001 |
Temporary equity shares authorized | 0 | 182,772,372 |
Temporary equity shares issued | 0 | 182,772,372 |
Temporary equity shares outstanding | 0 | 182,772,372 |
Preferred stock par or stated value per share | $ 0.001 | $ 0.001 |
Preferred stock shares authorized | 10,000,000 | 0 |
Preferred stock shares issued | 0 | 0 |
Preferred stock shares outstanding | 0 | 0 |
Common Class A [Member] | ||
Common stock, Par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 500,000,000 | 273,986,920 |
Common stock, Shares issued | 20,968,376 | 355,296 |
Common stock, Shares outstanding | 20,968,376 | 355,296 |
Common Class B [Member] | ||
Common stock, Par value | $ 0.001 | $ 0.001 |
Common stock, shares authorized | 14,600,000 | 21,593,607 |
Common stock, Shares issued | 309,238 | 0 |
Common stock, Shares outstanding | 309,238 | 0 |
Statements of Operations and Co
Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Operating expenses: | ||
Research and development | $ 22,484 | $ 45,206 |
General and administrative | 11,918 | 4,039 |
Restructuring Charges | 0 | 2,996 |
Total operating expenses | 34,402 | 52,241 |
Loss from operations | (34,402) | (52,241) |
Other income (expense): | ||
Interest income | 15 | 8 |
Interest expense | (20) | (166) |
Gain on issuance of convertible notes | 63 | |
Change in fair value of convertible notes | (1,076) | |
Change in fair value of non-marketable equity securities | (892) | |
Gain on sale of PNAi technology | 2,691 | |
Total other income (expense) | 1,794 | (1,171) |
Loss before provision for income taxes | (32,608) | (53,412) |
Provision for income taxes | (1) | (1) |
Net loss and comprehensive loss | $ (32,609) | $ (53,413) |
Net loss per share attributable to common stockholders, basic and diluted | $ (2.43) | $ (166.93) |
Weighted-average shares used in computing net loss per share attributable to common stockholders, basic and diluted | 13,435,706 | 319,963 |
Statements of Redeemable Conver
Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) $ in Thousands | Total | Additional Paid-in Capital [Member] | Accumulated Deficit [Member] | Redeemable Convertible Preferred Stock [Member] | Common Class A [Member] | Common Class A [Member]Common Stock [Member] | Common Class B [Member] |
Beginning Balance, Temporary Equity, shares at Dec. 31, 2019 | 14,015,773 | ||||||
Beginning Balance, Temporary Equity Value at Dec. 31, 2019 | $ 40,095 | ||||||
Beginning balance, shares at Dec. 31, 2019 | 322,007 | ||||||
Beginning Balance, Value at Dec. 31, 2019 | $ (36,548) | $ 1,486 | $ (38,034) | ||||
Issuance of Series C redeemable convertible preferred stock, net of issuance cost of $389 | $ 79,611 | ||||||
Issuance of Series C redeemable convertible preferred stock, net of issuance cost of $389, shares | 135,180,800 | ||||||
Issuance of Series C redeemable convertible preferred stock upon extinguishment of convertible notes | 5,736 | $ 6,749 | |||||
Issuance of Series C redeemable convertible preferred stock for license upon extinguishment of convertible notes | 11,404,246 | ||||||
Issuance of Series C redeemable convertible preferred stock for license | 13,121 | $ 13,121 | |||||
Issuance of Series C redeemable convertible preferred stock for license, share | 22,171,553 | ||||||
Issuance of Class A common stock upon exercise of options | 282 | 282 | |||||
Issuance of Class A common stock upon exercise of options, shares | 33,289 | ||||||
Stock-based compensation | 331 | 331 | |||||
Net loss | (53,413) | (53,413) | |||||
Ending Balance, shares at Dec. 31, 2020 | 355,296 | ||||||
Ending Balance, Value at Dec. 31, 2020 | $ (89,348) | 2,099 | (91,447) | ||||
Ending Balance, Temporary Equity , shares at Dec. 31, 2020 | 182,772,372 | 182,772,372 | |||||
Ending Balance, Temporary Equity Value at Dec. 31, 2020 | $ 139,576 | ||||||
Stock shares issued during the period value | $ 48,411 | 48,406 | $ 5 | ||||
Stock shares issued during the period new issues shares | 5,002,500 | ||||||
Conversion of preferred stock into common stock | 139,576 | 139,560 | $ (139,576) | $ 16 | |||
Conversion of preferred stock into common stock, Shares | (182,772,372) | 15,464,775 | 309,238 | ||||
Issuance of Class A common stock upon exercise of options | 550 | 550 | |||||
Issuance of Class A common stock upon exercise of options, shares | 145,805 | ||||||
Stock-based compensation | 3,012 | 3,012 | |||||
Net loss | (32,609) | (32,609) | |||||
Ending Balance, shares at Dec. 31, 2021 | 20,968,376 | 309,238 | |||||
Ending Balance, Value at Dec. 31, 2021 | $ 69,592 | $ 193,627 | $ (124,056) | $ 21 | |||
Ending Balance, Temporary Equity , shares at Dec. 31, 2021 | 0 |
Statements of Redeemable Conv_2
Statements of Redeemable Convertible Preferred Stock and Stockholders' Equity (Deficit) (Parenthetical) $ in Thousands | 12 Months Ended |
Dec. 31, 2020USD ($) | |
Series C Redeemable Convertible Preferred Stock [Member] | |
Net of issuance costs | $ 389 |
Condensed Statements of Cash Fl
Condensed Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Cash flows from operating activities | ||
Net loss | $ (32,609) | $ (53,413) |
Adjustments to reconcile net loss to net cash used in operating activities: | ||
Depreciation, amortization and accretion | 176 | 251 |
Impairment loss on property and equipment and intangible asset | 1,185 | |
Stock-based compensation | 3,012 | 331 |
Issuance of Series C redeemable convertible preferred stock for license | 13,121 | |
Payment for MAU868 asset purchase | 5,000 | |
Restructuring payments | (999) | (2,423) |
Non-cash interest expense on convertible notes | 134 | |
Issuance costs for convertible notes | 23 | |
Gain on issuance of convertible notes | (63) | |
Gain on sale of PNAi technology | (2,691) | |
Change in fair value of convertible notes | 1,076 | |
Change in fair value of non-marketable equity securities | 892 | |
Changes in operating assets and liabilities: | ||
Prepaid expense and other current assets | (2,306) | (135) |
Other assets | (51) | 59 |
Accounts payable | 475 | 567 |
Accrued and other current liabilities | 5,393 | 110 |
Other liabilities | (478) | |
Net cash used in operating activities | (23,708) | (34,809) |
Cash flows from investing activities | ||
Proceeds from sale of PNAi technology | 796 | |
Payment for MAU868 asset purchase | (5,000) | |
Purchase of property and equipment | (99) | |
Proceeds from the sale of property and equipment | 57 | |
Net cash provided by (used in) investing activities | (4,204) | (42) |
Cash flows from financing activities | ||
Proceeds from exercise of stock options | 550 | 230 |
Proceeds from Issuance of Series C Redeemable Convertible Preferred Stock | 80,000 | |
Payment of issuance costs related to issuance of redeemable convertible preferred stock | (389) | |
Proceeds from issuance of convertible notes | 5,602 | |
Proceeds from issuance of Class A common stock upon initial public offering, net of underwriting discounts and commissions | 51,176 | |
Proceeds from borrowings, net of costs | 4,921 | |
Payment of offering costs related to initial public offering | (2,765) | |
Payment of issuance costs related to convertible promissory notes | (23) | |
Payment on capital lease obligations | (130) | |
Net cash provided by financing activities | 53,882 | 85,290 |
Net increase (decrease) in cash and cash equivalents and restricted cash | 25,970 | 50,439 |
Cash, cash equivalents and restricted cash, beginning of year | 53,997 | 3,558 |
Cash, cash equivalents and restricted cash, end of year | 79,967 | 53,997 |
Supplemental disclosure of cash flow information | ||
Cash paid for interest | 17 | 32 |
Issuance of Series C redeemable convertible preferred stock for license | 13,121 | |
Issuance of Series C redeemable convertible preferred stock upon extinguishment of convertible notes | 5,736 | |
Receivable on Exercise of Stock Options | 52 | |
Reclassification of redeemable convertible preferred stock into common stock upon initial public offering | 139,576 | |
Non-marketable equity securities received as partial proceeds from sale of PNAi technology | 1,759 | |
Lease assignment | 136 | |
Liability assumed in connection with MAU868 asset purchase | 2,000 | |
Cash and cash equivalents [Member] | ||
Cash flows from financing activities | ||
Cash, cash equivalents and restricted cash, beginning of year | 53,654 | |
Cash, cash equivalents and restricted cash, end of year | 79,674 | 53,654 |
Restricted cash [Member] | ||
Cash flows from financing activities | ||
Cash, cash equivalents and restricted cash, beginning of year | 343 | |
Cash, cash equivalents and restricted cash, end of year | $ 293 | $ 343 |
Organization and Description of
Organization and Description of the Business | 12 Months Ended |
Dec. 31, 2021 | |
Organization Consolidation And Presentation Of Financial Statements [Abstract] | |
Organization and Description of the Business | 1. ORGANIZATION AND DESCRIPTION OF THE BUSINESS Description of Business Vera Therapeutics, Inc., (the Company) is a clinical late-stage biotechnology company focused on developing and commercializing transformative treatments for patients with serious immunological diseases. The Company is headquartered in Brisbane, California and was incorporated in May 2016 in Delaware. In 2017, the Company acquired all of the outstanding shares of PNA Innovations, Inc. (PNAi), which was based in Woburn, Massachusetts. Reverse Stock Split On May 7, 2021, the Company filed a certificate of amendment to its fourth amended and restated certificate of incorporation to effect a 11.5869 -for-one reverse stock split of its issued and outstanding Class A common stock. Adjustments corresponding to the reverse stock split were made to the ratio at which the Company’s redeemable convertible preferred stock converted into Class A common stock. Accordingly, all share and per share amounts related to Class A common stock, stock options and restricted stock awards for all periods presented in the accompanying financial statements and notes thereto have been retroactively adjusted, where applicable to reflect the reverse stock split. Initial Public Offering On May 13, 2021, the Company’s registration statement on Form S-1 for its initial public offering (the IPO) was declared effective by the Securities and Exchange Commission (the SEC), and the shares of its Class A common stock commenced trading on the Nasdaq Global Select Market on May 14, 2021. The IPO closed on May 18, 2021, pursuant to which the Company issued and sold 4,350,000 shares of its Class A common stock at a public offering price of $ 11.00 per share. On May 20, 2021, the Company issued 652,500 shares of its Class A common stock to the underwriters of the IPO pursuant to the exercise of the underwriters’ option to purchase additional shares. The Company received total net proceeds of $ 48.4 million from the IPO, after deducting underwriting discounts and commissions of $ 3.9 million, and offering costs of $ 2.8 million. Prior to the completion of the IPO, all shares of redeemable convertible preferred stock then outstanding were converted into 15,464,776 shares of Class A common stock and 309,238 shares of Class B common stock. Liquidity Since inception, the Company devoted substantially all of its resources to its research and development efforts, pre-clinical studies and clinical trials, establishing and maintaining its intellectual property portfolio, hiring personnel, raising capital, and providing general and administrative support for these operations. The Company has incurred recurring net operating losses since its inception and had an accumulated deficit of $ 124.1 million as of December 31, 2021. The Company had cash and cash equivalents of $ 79.7 million as of December 31, 2021 and has not generated positive cash flow from operations. The Company has funded its operations primarily through the issuance of common stock, redeemable convertible preferred stock and convertible notes. Management expects to continue to incur losses and negative cash flows from operations for at least the next several years. Management believes that the Company’s cash and cash equivalents as of December 31, 2021 , together with net proceeds from its follow-on public offering in February 2022 (see Note 18), will be sufficient to fund its operating expenses and capital expenditure requirements for at least 12 months subsequent to the issuance date of these financial statements. The Company intends to raise additional capital through public or private equity offerings or debt financing or other capital sources, which may include strategic collaborations or other arrangements with third parties in order to achieve its long-term business objectives. If the Company fails to obtain necessary capital when needed on acceptable terms, or at all, it could force the Company to delay, limit, reduce or terminate its product development programs, commercialization efforts or other operations. |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 12 Months Ended |
Dec. 31, 2021 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | 2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES Basis of Presentation The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (GAAP) and applicable rules and regulations of the SEC regarding financial reporting. The U.S. dollar is the Company’s functional and reporting currency. Emerging Growth Company Status The Company is an emerging growth company as defined in the Jumpstart Our Business Startups Act of 2012 (JOBS Act). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with certain new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it (1) is no longer an emerging growth company or (2) affirmatively and irrevocably opts out of the extended transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates. Use of Estimates The preparation of the Company’s financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. Management estimates that affect the reported amounts of assets and liabilities include the accrual of research and development expenses, restructuring liabilities, fair value of common stock and stock-based compensation expense, and the valuation allowance for deferred tax assets. The Company evaluates and adjusts its estimates and assumptions on an ongoing basis using historical experience and other factors. Actual results could differ materially from those estimates. Deferred Offering Costs Deferred offering costs consisting of legal, accounting and filing fees relating to the IPO are capitalized. The deferred offering costs were offset against the Company’s IPO proceeds upon the closing of the IPO. Concentrations of Credit Risk and Other Risks and Uncertainties Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains bank deposits in a federally insured financial institution and these deposits may exceed federally insured limits. The Company is exposed to credit risk in the event of default by the financial institution holding its cash and cash equivalents to the extent recorded in the balance sheet. The Company has not experienced any losses on its deposits of cash and cash equivalents. The Company’s future results of operations involve a number of other risks and uncertainties. Factors that could affect the Company’s future operating results and cause actual results to vary materially from expectations include, but are not limited to, uncertainty of results of clinical trials and reaching milestones, uncertainty of regulatory approval of the Company’s current and potential future product candidates, uncertainty of market acceptance of the Company’s product candidates, competition from substitute products and larger companies, securing and protecting proprietary technology, strategic relationships and dependence on key individuals or sole-source suppliers. The Company’s product candidates require approvals from the U.S. Food and Drug Administration and comparable foreign regulatory agencies prior to commercial sales in their respective jurisdictions. There can be no assurance that any product candidates will receive the necessary approvals. If the Company was denied approval, approval was delayed, or the Company was unable to maintain approval for any product candidate, it could have a materially adverse impact on the Company. Impact of the COVID-19 Pandemic The COVID-19 pandemic continues to evolve. The extent of the impact of the COVID-19 pandemic on the Company’s business, operations, and development timelines and plans remains uncertain, and will depend on certain developments, including the duration and spread of the outbreak and its impact on the Company’s development activities, planned clinical trial enrollment, future trial sites, contract research organizations, third-party manufacturers, and other third parties with whom the Company does business, as well as its impact on regulatory authorities and the Company’s key scientific and management personnel. The ultimate impact of the COVID-19 pandemic or a similar health epidemic is highly uncertain and subject to change. To the extent possible, the Company is conducting business as usual, with necessary or advisable modifications to employee travel and with the Company’s employees mostly working remotely. The Company will continue to actively monitor the evolving situation related to the COVID-19 pandemic and may take further actions that alter the Company’s operations, including those that may be required by federal, state or local authorities, or that the Company determines are in the best interests of its employees and other third parties with whom the Company does business. At this point, the extent to which the COVID-19 pandemic may affect the Company’s business, operations and development timelines and plans, including the resulting impact on expenditures and capital needs, remains uncertain. Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents. Cash equivalents consist of money market funds and are stated at fair value. Restricted Cash Restricted cash represents cash held by a financial institution as collateral for a letter of credit securing its operating lease for office and laboratory space, which is classified within current and non-current assets on the balance sheets. Comprehensive Loss Comprehensive loss consists of net loss and other gains and losses affecting redeemable convertible preferred stock and stockholders’ equity (deficit) that, under GAAP, are excluded from net loss. The Company has no items of other comprehensive loss for the year ended December 31, 2021 and 2020 . As such, net loss equals comprehensive loss. Research and Development Costs Research and development costs are expensed as incurred and consist primarily of employees’ salaries and related benefits, including stock-based compensation and termination expenses for employees engaged in research and development efforts, allocated overhead including rent, depreciation, information technology and utilities, contracted services, license fees, and external expenses to conduct and support the Company’s operations that are directly attributable to the Company’s research and development efforts. Payments made to third parties under these arrangements in advance of the performance of the related services by the third parties are recorded as prepaid expenses until the services are rendered. Costs incurred in obtaining technology licenses including upfront and milestone payments incurred under the Company’s licensing agreements are recorded as expense in the period in which they are incurred, provided that the licensed technology, method or process has no alternative future uses other than for the Company’s research and development activities. Where contingent milestone payments are due to third parties under license or other agreements, the milestone payment obligations are recognized as expense when achievement of the contingent milestone is probable, which is generally upon achievement of the milestone. Research Contract Costs and Accruals The Company enters into various research and development and other agreements with commercial firms, researchers, and others for provisions of goods and services from time to time. These agreements are generally cancellable, and the related costs are recorded as research and development expenses as incurred. The Company records accruals for estimated ongoing research and development costs. When evaluating the adequacy of the accrued liabilities, the Company analyzes progress of the studies or clinical trials, including the phase or completion of events, invoices received and contracted costs. These expenses and accrued liabilities are adjusted as actual expenses become known. Significant judgments and estimates are made in determining the accrued balances at the end of any reporting period. Actual results could differ materially from the Company’s estimates. Redeemable Convertible Preferred Stock The Company records all shares of redeemable convertible preferred stock at their respective fair values on the dates of issuance, net of issuance costs. The carrying value of the Company’s redeemable convertible preferred stock is adjusted to reflect dividends if and when declared by the Company’s board of directors. No dividends have been declared by the board of directors since inception. The Company classifies its redeemable convertible preferred stock separate from total stockholders’ equity (deficit), as the redemption of such stock is not solely under the control of the Company. Stock-Based Compensation The Company recognizes compensation expense based on estimated fair values for all stock-based payment awards made to the Company’s employees, nonemployee directors and consultants that are expected to vest. The valuation of stock option awards is determined at the date of grant using the Black-Scholes option pricing model. The Black-Scholes option pricing model requires the Company to make assumptions and judgements about the inputs used in the calculations, such as the fair value of the common stock, expected term, expected volatility of the Company’s common stock, risk-free interest rate and expected dividend yield. The valuation of restricted stock awards is measured by the fair value of the Company’s common stock on the date of the grant. For all stock options granted, the Company calculated the expected term using the simplified method (derived from the average midpoint between the weighted average vesting period and the contractual term of the award) for “plain vanilla” stock option awards, as the Company has limited historical information to develop expectations about future exercise patterns and post vesting employment termination behavior. The estimate of expected volatility is based on comparative companies’ volatility. The risk-free rate is based on the yield available on United States Treasury zero-coupon issues corresponding to the expected term of the award. The Company records forfeitures when they occur. Prior to the completion of our initial public offering, the fair value of the shares of common stock underlying the stock options was determined by the board of directors with the assistance of management and input from an independent third-party valuation firm, as there was no public market for the common stock. The board of directors determined the fair value of the Company’s common stock by considering a number of objective and subjective factors, including the valuation of comparable companies, sales of redeemable convertible preferred stock, the Company’s operating and financial performance, the lack of liquidity of common stock, and general and industry specific economic outlook, amongst other factors. The Company records compensation expense for service-based awards on a straight-line basis over the requisite service period, which is generally the vesting period of the award. The amount of stock-based compensation expense recognized during a period is based on the value of the portion of the awards that are ultimately expected to vest. Income Taxes Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect tax rates expected to be in effect for the years in which the differences are expected to be reversed. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized. Net Loss Per Share Attributable to Common Stockholders Net loss per share of common stock is computed using the two-class method required for multiple classes of common stock and participating securities based upon their respective rights to receive dividends as if all income for the period has been distributed. The rights, including the liquidation and dividend rights and sharing of losses, of the Class A and Class B common stock are identical, other than voting rights. As the liquidation and dividend rights and sharing of losses are identical, the undistributed earnings are allocated on a proportionate basis and the resulting net loss per share attributed to common stockholders is therefore the same for Class A and Class B common stock on an individual or combined basis. The Company’s participating securities include the Company’s redeemable convertible preferred stock, as the holders were entitled to receive noncumulative dividends on a pari passu basis in the event that a dividend is paid on common stock. The Company also considers any shares issued on the early exercise of stock options subject to repurchase to be participating securities because holders of such shares have non-forfeitable dividend rights in the event a dividend is paid on common stock. The holders of redeemable convertible preferred stock, as well as the holders of early exercised shares subject to repurchase, did not and do not have a contractual obligation to share in losses of the Company, and therefore during periods of loss there is no allocation required under the two-class method. Basic net loss per share attributable to common stockholders is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, adjusted for outstanding shares that are subject to repurchase. Diluted net loss per share is computed by giving effect to all potentially dilutive securities outstanding for the period using the treasury stock method or the if-converted method based on the nature of such securities. For periods in which the Company reports net losses, diluted net loss per share attributable to common stockholders is the same as basic net loss per share attributable to common stockholders, because potentially dilutive shares are not assumed to have been issued if their effect is anti-dilutive. Leases The Company leases office and laboratory space under operating leases and laboratory equipment under capital leases. Leases for which the Company assumes substantially all risks and rewards incidental to ownership of the leased assets are classified as capital leases. The leased assets and the corresponding lease liabilities (net of interest charges) are recognized on the balance sheet as property and equipment, based on the cost of the equipment, and borrowings, respectively, at the inception of the related lease. Each lease payment is apportioned between the reduction of the outstanding lease liability and the related interest expense. The interest expense is recorded on a basis that reflects a constant periodic rate of interest on the outstanding finance lease liability. Leases for which substantially all risks and rewards incidental to ownership are retained by the lessors are classified as operating leases. Payments made under operating leases (net of any incentive received from the lessors) are recorded on a straight-line basis over the period of the lease. Restructuring Costs Restructuring costs primarily consist of contract termination costs related to leases and employee termination costs. The Company recognizes restructuring charges when the liability has been incurred. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations, cease use date of leased property and equipment, and the timing of employees leaving the Company. Accretion expenses related to restructuring costs are included in general and administrative expenses. Fair Value Option The convertible notes issued in 2020, for which the Company elected the fair value option, are accounted for at fair value on a recurring basis with changes in fair value recognized in the statement of operations and comprehensive loss. Interest accrued on the convertible notes was recorded to interest expense during the periods in which the convertible notes were outstanding. Fair Value Measurements Fair value is defined as the exchange price to sell an asset or transfer a liability (exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants at the measurement date. Fair value should be based on the assumptions market participants would use when pricing the asset or liability. The valuation hierarchy is based upon the transparency of inputs to the valuation of an asset or liability as of the measurement date. Fair value measurements are classified and disclosed in one of the following three categories: Level 1 – Quoted unadjusted prices for identical instruments in active markets. Level 2 – Quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in markets that are not active, and model-derived valuations in which all observable inputs and significant value drivers are observable in active markets. Level 3 – Model derived valuations in which one or more significant inputs or significant value drivers are unobservable, including assumptions developed by the Company. The carrying amounts of the Company’s cash and cash equivalents, prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair value due to their short-term nature. The carrying amount of debt approximates fair value due to its variable interest rate. Money market funds are highly liquid investments that are actively traded. The pricing information for the Company’s money market funds are readily available and can be independently validated as of the measurement date. This approach results in the classification of these securities as Level 1 of the fair value hierarchy. The Company’s non-marketable equity securities (Note 5) are measured at fair value using an option pricing valuation methodology. The option pricing methodology relies on risk-neutral valuation which calculates the value of an asset by discounting the expected value of its future payoffs at the risk-free rate of return. The fair value of the non-marketable equity securities is derived from quoted prices for similar instruments and observable inputs in active markets. This approach results in the classification of these securities as Level 2 of the fair value hierarchy. There were no transfers between Levels 1, 2, or 3 for any of the periods presented. As of December 31, 2021 and 2020 , the Company held $ 73.8 million and $ 52.3 million, respectively, in money market funds with no unrealized gains or losses. Recently Adopted Accounting Pronouncements In December 2019, the Financial Accounting Standards Board (FASB) issued Accounting Standard Update (ASU) No. 2019-12, Income Taxes (Topic 740) , Simplifying the Accounting for Income Taxes , related to simplifying the accounting for income taxes. The guidance eliminates certain exceptions from Accounting Standards Codification (ASC) 740 related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. The guidance also clarifies and simplifies other aspects of the accounting for income taxes. The guidance became effective for the Company beginning on the first quarter of 2021 on a prospective basis. The Company adopted this standard on January 1, 2021, and it did not have a material impact on the Company's financial statements or related disclosures. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting , to reduce cost and complexity and to improve financial reporting for share-based payments issued to nonemployees (for example, service providers, external legal counsel, suppliers, etc.). This includes allowing for the measurement of awards at the grant date and recognition of awards with performance conditions when those conditions are probable, both of which are earlier than under current guidance for nonemployee awards. The Company adopted this standard as of January 1, 2020 on a retrospective basis. The adoption of this standard did not have a material impact on its financial statements. In August 2018, the FASB issued ASU No. 2018-13, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement , which amends ASC 820, Fair Value Measurement. This standard modifies the disclosure requirements for fair value measurements by removing, modifying, or adding certain disclosures. The Company adopted this standard as of January 1, 2020 on a retrospective basis. The adoption of this standard did not have a material impact on its financial statements . Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases (Topic 842) , subsequently amended by ASU 2018-10, ASU 2018-11, ASU 2018-20, ASU 2019-01 and ASU 2019-10, which sets out the principles for the recognition, measurement, presentation and disclosure of leases for both lessors and lessees of a contract. The new standard requires lessees to apply a dual approach, classifying leases as either finance or operating leases based on the principle of whether or not the lease is effectively a financed purchase by the lessee. This classification will determine whether lease expense is recognized based on an effective interest method or on a straight-line basis over the term of the lease. A lessee is also required to record a right-of-use asset and a lease liability for all leases with a term of greater than 12 months regardless of their classification on the balance sheets. Leases with a term of 12 months or less may be accounted for similar to existing guidance for operating leases today. The Company adopted the prospective approach as of January 1, 2022. Additionally, the Company intends to use the package of available practical expedients, which allows it to (i) not reassess whether any expired or existing contracts are or contain leases; (ii) not reassess the lease classification for expired or existing leases; and (iii) not reassess the treatment of initial direct costs for any existing leases. The Company also has elected the practical expedient to not separate lease and non-lease components for all leases. The Company has substantially completed its evaluation of the effect that the adoption of this guidance will have on its financial statements. In connection with the adoption of the new guidance, the Company expects to recognize lease liabilities of approximately $ 9.0 million and right-of-use assets of approximately $ 7.0 million for operating leases, with immaterial impact to its statements of operations and cash flows. In June 2016, the FASB issued ASU 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments . The objective of the standard is to provide information about expected credit losses on financial instruments at each reporting date and to change how other-than temporary impairments on investment securities are recorded. The guidance is effective for the Company beginning on January 1, 2023, with early adoption permitted. The Company is currently evaluating the impact the standard may have on its financial statements and related disclosures. In March 2020, the FASB issued ASU No. 2020-04, Reference Rate Reform (Topic 848) : Facilitation of the Effects of Reference Rate Reform on Financial Reporting . In response to concerns about structural risks of the cessation of London Interbank Offered Rate (LIBOR), the amendments in this ASU provide optional guidance for a limited time to ease the potential burden in accounting for (or recognizing the effect of) reference rate reform on financial reporting. The amendments in this ASU provide optional expedients and exceptions for applying GAAP to contracts, hedging relationships and other transactions affected by reference rate reform if certain criteria are met. The expedients and exceptions provided by this amendment do not apply to contract modifications made and hedge relationships entered into or evaluated after December 31, 2022. The amendments in this ASU are elective and are effective for all entities as of March 12, 2020 through December 31, 2022. The Company continues to evaluate contractual arrangements that reference LIBOR. In August 2020, the FASB issued ASU No. 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40) . This standard simplifies the accounting for convertible debt instruments and convertible preferred stock by removing the existing guidance in ASC 470-20 that requires entities to account for beneficial conversion features and cash conversion features in equity, separately from the host convertible debt or preferred stock. ASU 2020-06 is effective for the Company for annual reporting periods, and interim reporting periods within those annual periods, beginning after December 15, 2023, and early adoption is permitted. The Company is currently evaluating the impact this standard will have on its financial statements and related disclosures. |
Other Financial Statement Infor
Other Financial Statement Information | 12 Months Ended |
Dec. 31, 2021 | |
Other Financial Statement Information [Abstract] | |
Other Financial Statement Information | 3. OTHER FINANCIAL STATEMENT INFORMATION Prepaid Expense and Other Current Assets Prepaid expenses and other current assets consist of the following (in thousands) . December 31, 2021 2020 Prepaid insurance $ 1,193 $ 27 Prepaid contract costs 320 — Prepaid follow-on financing costs 275 — Prepaid recruiting fees 253 — Prepaid rent 219 — Prepaid audit fees 123 — Deposits 57 86 Receivables from exercise of options — 52 Other 423 392 Total prepaid expenses and other current assets $ 2,863 $ 557 Accrued Expenses and Other Current Liabilities Accrued expenses and other current liabilities consist of the following (in thousands) . December 31, 2021 2020 Accrued development milestone $ 2,000 $ — Accrued payroll 1,458 405 Related party payable 1,022 — Accrued legal fees 457 — Accrued research and development contract costs 364 — Accrued consulting fees 341 — Accrued expenses and other 286 130 Total accrued expenses and other current liabilities $ 5,928 $ 535 Related party payable represents amounts due to Ares Trading S.A. (Ares), an affiliate of Merck KGaA, Darmstadt, Germany, related to manufacturing technology and know-how transfer services performed for atacicept pursuant to the license agreement between the Company and Ares (see Note 12). |
Neubase Asset Sale
Neubase Asset Sale | 12 Months Ended |
Dec. 31, 2021 | |
Neubase Asset Sale [Abstract] | |
Neubase Asset Sale | 4. NEUBASE ASSET SALE On January 27, 2021, the Company entered into an asset purchase agreement with NeuBase Therapeutics, Inc. (NeuBase), whereby the Company agreed to sell all assets relating to its investment in PNAi, including all inventory, machinery, intellectual property, goodwill, and licenses, and NeuBase agreed to assume certain related liabilities. The sale of the Company’s investment in PNAi closed on April 26, 2021. The Company received $ 0.8 million in cash and 308,635 shares of NeuBase common stock, with a fair market value of $ 1.8 million based on the closing price reported on the Nasdaq Capital Market on the date the sale closed. Of the total NeuBase shares issued to the Company, 162,260 were placed in escrow to secure certain obligations under the asset purchase agreement. In connection with the sale, the Company also assigned certain leases for research and laboratory equipment to NeuBase (see Note 14). The Company recognized a gain of $ 2.7 million on the sale of assets to NeuBase. As of December 31, 2021, there were 54,070 shares eligible for release from escrow. Per the terms of the agreement, the shares may be released from escrow upon the execution of a joint instruction letter. |
Non-Marketable Equity Securitie
Non-Marketable Equity Securities | 12 Months Ended |
Dec. 31, 2021 | |
Investments Debt And Equity Securities [Abstract] | |
Non-Marketable Equity Securities | 5. NON-MARKETABLE EQUITY SECURITIES The Company has an investment in NeuBase common stock with restrictions on the sale or transfer of the shares. Fair value is determined using alternative pricing sources and models utilizing market observable inputs. The Company reports the restricted equity securities as non-marketable equity securities on the balance sheet, and determines current or non-current classification based on the expected duration of the restriction. The Company recorded a net unrealized loss of $ 0.9 million in other expense for the year ended December 31, 2021 . The carrying value is measured as the total initial cost, less the cumulative net unrealized loss. The carrying value of the non-marketable equity securities as of December 31, 2021, is summarized below (in thousands) . Initial cost as of April 26, 2021 $ 1,759 Change in fair value ( 892 ) Balance as of December 31, 2021 $ 867 |
Note Payable
Note Payable | 12 Months Ended |
Dec. 31, 2021 | |
Debt Disclosure [Abstract] | |
Note Payable | 6. NOTE PAYABLE Note payable consists of the following: Rate Type Maturity Effective Interest Rate December 31, (in thousands) Collateralized note Variable 2026 9.53 % $ 5,000 Less: Debt issuance costs ( 77 ) Net carrying amount of debt $ 4,923 The carrying amount of debt approximates fair value due to its variable interest rate. The Company did no t have any outstanding debt as of December 31, 2020. In December 2021, the Company entered into a loan and security agreement (the Loan Agreement) for a non-revolving c redit facility with borrowing capacity of up to $ 50.0 million. An initial $ 5.0 million (the Loan) was funded in December 2021, and an additional $ 45.0 million will be available in minimum draws of $5.0 million, at the Company’s option through the end of 2022. The Loan matures in December 2026, which may be extended by 12 months subject to certain clinical data milestones. The debt facility provides for at least 48-months of interest-only payments, which may be extended to 60 months if the final maturity date is extended. Initially, the Loan bears interest at 8.25 %, with a floating interest rate tied to LIBOR. The Company is permitted to prepay the loan, subject to certain conditions. Upon the maturity date or prepayment of the Loan, the Company is required to make a final payment equal to 5.0 % (or 7.0 % if the maturity date is extended) of the aggregate principal amount of the Loan. The Loan Agreement contains a subjective acceleration clause in the case of an event of default. If such a matter occurs and is continuing, the lender may legally demand the outstanding principal and interest immediately due and payable. There are no financial covenants associated with the credit facility and the Loan is secured by the Company’s assets. Principal installments due on the note subsequent to December 31, 2021 are as follows (in thousands) : 2022 $ — 2023 — 2024 — 2025 — 2026 5,000 Total accrued expenses and other current liabilities $ 5,000 |
Convertible Notes
Convertible Notes | 12 Months Ended |
Dec. 31, 2021 | |
Debt Disclosure [Abstract] | |
Convertible Notes | 7. CONVERTIBLE NOTES In March 2020, the Company issued convertible notes to certain existing investors of the Company for cash. The principal amount of the convertible notes was $ 5.0 million in the aggregate with a fixed accrued interest rate of 4 % per annum. The convertible notes were either due on or after December 31, 2020, or upon a change of control of the Company, unless earlier converted. No principal or interest was payable prior to maturity as the convertible notes and any accrued interest would automatically convert upon a qualified financing event at a conversion price equal to 85 % of the price per share of the qualified financing. Holders also had the option to convert their notes to shares of Series B redeemable convertible stock at a conversion price equal to $ 4.2926 per share on the maturity date or upon a change of control of the Company, if no qualified financing occurred prior to such date. Due to certain embedded features within the convertible notes, the Company elected to account for the convertible notes under the fair value option. In April and May 2020, the Company issued additional convertible notes to certain existing investors of the Company for cash. The principal amount of the convertible notes was $ 0.6 million in the aggregate with the same terms as the convertible notes issued in March 2020. In October 2020, the outstanding principal and accrued interest of $ 0.1 million, were automatically converted into 11,404,246 shares of the Company’s Series C redeemable convertible preferred stock in connection with the closing of the Company’s Series C redeemable convertible preferred stock financing (see Note 8) at a conversion price of $ 0.5030 per share, which was 85 % of the $ 0.5918 original issuance price of the Series C redeemable convertible preferred stock. |
Redeemable Convertible Preferre
Redeemable Convertible Preferred Stock | 12 Months Ended |
Dec. 31, 2021 | |
Temporary Equity [Abstract] | |
Redeemable Convertible Preferred Stock | 8. REDEEMABLE CONVERTIBLE PREFERRED STOCK As of December 31, 2020, the Company’s redeemable convertible preferred stock consisted of the following balances. ISSUE PRICE SHARES SHARES ISSUED CARRYING AGGREGATE (in thousands) (in thousands) Series Seed $ 1.01 1,010,456 1,010,456 $ 1,789 $ 1,020 Series Seed-1 1.92 1,787,640 1,787,640 3,718 3,430 Series A 2.15 6,120,111 6,120,111 12,851 13,136 Series B 4.29 5,097,566 5,097,566 21,737 21,882 Series C 0.59 168,756,599 168,756,599 99,481 99,870 Total 182,772,372 182,772,372 $ 139,576 $ 139,338 In October 2020, the Company issued 135,180,800 shares of Series C redeemable convertible preferred stock for a purchase price of $ 0.5918 per share, payable in cash. Gross proceeds to the Company were $ 80.0 million. The Series C redeemable convertible preferred stock financing triggered the automatic conversion of the Company’s outstanding convertible notes into 11,404,246 shares of Series C redeemable convertible preferred stock based on price of $ 0.5030 per share ( 85 % of the $ 0.5918 original issuance price of the Series C redeemable convertible preferred stock). In addition, the Company issued 22,171,553 shares of Series C redeemable convertible preferred stock to Ares as the initial payment for the Company’s license of atacicept from Ares (see Note 12). In May 2021, immediately prior to the completion of the IPO (see Note 1), all outstanding shares of redeemable convertible preferred stock were automatically converted into 15,774,014 shares of common stock. |
Common Stock
Common Stock | 12 Months Ended |
Dec. 31, 2021 | |
Stockholders' Equity Note [Abstract] | |
Common Stock | 9. COMMON STOCK As of December 31, 2021 , the Company’s certificate of incorporation, as amended and restated, authorized the Company to issue 500,000,000 shares of Class A common stock and 14,600,000 shares of Class B common stock, each with a par value of $ 0.001 per share. Each share of Class A common stock entitles the holder to one vote on all matters submitted to a vote of the Company’s stockholders. Class B common stock is non-voting. The holders of Class A common stock, voting exclusively and as a separate class, have the exclusive right to vote for the election of one director of the Company. Class A common stockholders and holders of Class B common stock are entitled to receive dividends, as may be declared by the board of directors. Through December 31, 2021 , no cash dividends have been declared or paid. |
Stock Compensation
Stock Compensation | 12 Months Ended |
Dec. 31, 2021 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Stock Compensation | 10. STOCK COMPENSATION In April 2021, the Company adopted the 2021 Employee Stock Purchase Plan (ESPP) and the 2021 Equity Incentive Plan (2021 EIP), each of which became effective in connection with the IPO. The Company has reserved 220,251 and 2,213,773 shares of Class A common stock for future issuance under the ESPP and 2021 EIP, respectively. The Company may not grant any additional awards under the 2017 Equity Incentive Plan (2017 EIP). The 2017 EIP will continue to govern outstanding equity awards granted thereunder. As of December 31, 2021 , there were 1,403,096 shares available for issuance under the 2021 EIP. 2017 EIP and 2021 EIP Stock option activity under the 2017 EIP and 2021 EIP was as follows: NUMBER OF WEIGHTED- WEIGHTED- AGGREGATE Outstanding as of December 31, 2020 1,855,507 $ 2.99 9.79 $ 8 Granted 1,217,914 9.36 Exercised ( 145,805 ) 3.77 Cancelled and forfeited ( 3,095 ) 9.39 Outstanding as of December 31, 2021 2,924,521 5.62 9.11 $ 61,712 Options exercisable as of 467,621 3.01 8.91 $ 11,089 Vested and expected to vest as of 2,924,521 $ 5.62 9.11 $ 61,712 The aggregate intrinsic value of stock options exercised during the year ended December 31, 2021 was $ 0.2 million. The weighted-average grant date fair value of options granted during the year ended twelve months ended December 31, 2021 and 2020, was $ 9.36 per share and $ 2.24 per share, respectively. ESPP The ESPP enables eligible employees to purchase shares of the Company's common stock at the end of each offering period at a price equal to 85 % of the fair market value of the shares on the first trading day or the last trading day of the offering period, whichever is lower. Eligible employees generally include all employees. Share purchases are funded through payroll deductions of at least 1 % and up to 15 % of an employee's eligible compensation for each payroll period. The number of shares reserved for issuance under the ESPP increase automatically on the first day of each fiscal year, beginning on January 1, 2022, by a number equal to the lesser of 440,502 shares, 1 % of the total number of shares of the Company's capital stock (including all classes of the Company's common stock) outstanding on the last day of the calendar month prior to the date of the increase, or such lower number of shares (including no shares) approved by the Company's board of directors. As of December 31, 2021, no shares have been issued pursuant to the ESPP. The ESPP generally provides for six-month consecutive offering periods beginning on September 14, 2021. The ESPP is a compensatory plan as defined by the authoritative guidance for stock compensation. As such, stock-based compensation expense has been recorded for the year ended December 31, 2021. Stock-Based Compensation Expense The following tables summarize the stock-based compensation expense for stock options and restricted stock awards granted to employees and nonemployees that was recorded in the Company’s statements of operations and comprehensive loss for the year ended December 31, 2021 and 2020 (in thousands) . Year Ended December 31, 2021 2020 Research and development $ 915 $ 4 General and administrative 2,097 327 Total stock-based compensation expense $ 3,012 $ 331 Year Ended December 31, 2021 2020 Employees $ 2,605 $ 321 Nonemployees 407 10 Total stock-based compensation expense $ 3,012 $ 331 As of December 31, 2021 , the Company had $ 11.8 million of unrecognized stock-based compensation expense related to unvested stock options and restricted stock awards, which is expected to be recognized over a weighted-average period of approximately 2.92 years. The fair value of stock options granted during the year ended December 31, 2021 and 2020 was estimated using the Black-Scholes option pricing model based on the following weighted average assumptions. Year Ended December 31, 2021 2020 Expected term (in years) 5.5 – 6.1 5.5 – 6.1 Expected volatility 75.4 % – 76.8 % 86.1 % – 92.5 % Risk-free rate 0.6 % – 1.3 % 0.41 % – 1.67 % Dividend yield — — Restricted Stock Awards In October 2020, in conjunction with the Series C redeemable convertible preferred stock issuance, the Company restricted 49,636 shares of fully issued and outstanding Class A common stock held by the Company’s Chief Executive Officer and founder. The restriction allows the Company to repurchase shares that have not vested. The vesting term of restricted stock is one year . The grant date fair value of the restricted shares was $ 6.37 . The following table summarizes the activity for the Company’s restricted stock for the year ended December 31, 2021. NUMBER OF SHARES Unvested as of December 31, 2020 41,363 Vested ( 41,363 ) Unvested as of December 31, 2021 — For the year ended December 31, 2021, the Company recognized $ 0.3 million of stock-based compensation expense related to restricted stock awards that vested during the period. |
Employee Benefit Plans
Employee Benefit Plans | 12 Months Ended |
Dec. 31, 2021 | |
Compensation And Retirement Disclosure [Abstract] | |
Employee Benefit Plans | 11. EMPLOYEE BENEFIT PLANS The Company sponsors a qualified 401(k) defined contribution plan covering eligible employees. Participants may contribute a portion of their annual compensation limited to a maximum annual amount set by the Internal Revenue Service. There were no employer contributions under this plan for the year ended December 31, 2021. |
License and Collaborations
License and Collaborations | 12 Months Ended |
Dec. 31, 2021 | |
Licenses And Collaborations [Abstract] | |
License and Collaborations | 12. LICENSES AND COLLABORATIONS Ares Trading S.A. In October 2020, the Company entered into a license agreement with Ares (the Ares Agreement), pursuant to which the Company obtained an exclusive worldwide license to certain patents and related know-how to research, develop, manufacture, use and commercialize therapeutic products containing atacicept, a recombinant fusion protein used to inhibit B cell growth and differentiation, which could potentially treat some autoimmune diseases. As consideration for the Ares Agreement, the Company issued to Ares a non-refundable license issue fee of 22,171,553 shares of Series C redeemable convertible preferred stock resulting in Ares becoming a related party to the Company. The Series C redeemable convertible preferred stock had a deemed issuance price of $ 0.5918 per share, or $ 13.1 million in the aggregate. In December 2020, the Company paid Ares $ 25.0 million in milestone payments upon delivery and initiation of the transfer of specified information and materials. The Company is obligated to pay Ares aggregate milestone payments of up to $ 176.5 million upon the achievement of specified BLA filing or regulatory approval milestones and up to $ 515.0 million upon the achievement of specified commercial milestones. The non-refundable license issue fee of $ 13.1 million and milestone payments of $ 25.0 million were recorded to research and development expense. Ares is performing manufacturing technology and know-how transfer to the Company over a period not to exceed two years from the effective date of the Ares Agreement. The Company recorded related party expense of $ 1.7 million to Ares for these services during the year ended December 31, 2021. Commencing on the first commercial sale of licensed products, the Company is obligated to pay Ares tiered royalties of low double-digit to mid-teen percentages on annual net sales of the licensed products covered by the license. The Company is obligated to pay royalties on a licensed product-by- licensed product and country-by-country basis from the first commercial sale of a product in a country until the latest of (i) 15 years after the first commercial sale of such licensed product in such country; (ii) the expiration of the last valid claim of a licensed patent that covers such licensed product in, or its use, importation or manufacture with respect to, such country; and (iii) expiration of all applicable regulatory exclusivity periods, including data exclusivity, in such country with respect to such product. If the Company were to sublicense its rights under the Ares Agreement, the Company is obligated to pay Ares a percentage ranging from the mid- single-digit to the low double-digits of specified sublicensing income received. Amplyx Pharmaceuticals Inc. In December 2021, the Company entered into an asset purchase agreement (the Amplyx Agreement) with Amplyx Pharmaceuticals Inc. (Amplyx), a wholly owned subsidiary of Pfizer. Pursuant to the terms of the Amplyx Agreement, the Company paid $ 5.0 million to Amplyx to purchase assets relating to an anti-BKV monoclonal antibody referred to as MAU868 for the treatment of BKV infection pursuant to a License Agreement between Amplyx and Novartis International Pharmaceutical AG (Novartis"). In addition, the Company has recognized a $ 2.0 million contingent milestone obligation that is probable of achievement as an assumed liability related to the asset purchase. The transaction was treated as an asset acquisition as the assets acquired did not meet the definition of a business. ASC 805-10-55 states that if substantially all the fair value of the gross assets acquired is concentrated in a single identifiable asset or group of similar identifiable assets, the set is not considered a business. Since the gross assets acquired are concentrated on a single identifiable asset, MAU868, the transaction was accounted for as an asset acquisition. In accordance with accounting guidance, costs incurred in obtaining technology licenses are charged to research and development expense if the technology licensed has not reached technological feasibility and has no alternative future use. The assets purchased from Amplyx require substantial completion of research and development, regulatory and marketing approval efforts in order to reach technological feasibility. Accordingly, the acquisition cost of $ 7.0 million was recorded as research and development expense in the statement of operations for the year ended December 31, 2021. In connection with the Amplyx asset purchase, Amplyx assigned the Exclusive License Agreement between Amplyx and Novartis (the Novartis License) and Manufacturing and Supply Agreements to the Company. Under the Novartis License Agreement, the Company has exclusive worldwide rights from Novartis to develop, manufacture and commercialize MAU868. The Company will be solely responsible for all research, development, regulatory, manufacturing and commercialization activities of MAU868. Under the Amplyx Agreement, the Company is obligated to make future milestone payments to Amplyx and Novartis totaling up to approximately $ 76.0 million, contingent upon the achievement of various clinical development and regulatory milestones. Of this total, the Company has recognized $ 2.0 million of future milestone payments to Novartis as assumed liabilities upon acquisition. In the event that MAU868 is commercialized, the Company is obligated to pay to Amplyx and Novartis royalties based on net sales by country and by product. |
Income Taxes
Income Taxes | 12 Months Ended |
Dec. 31, 2021 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | 13. INCOME TAXES For financial reporting purposes, income (loss) before provision for income taxes, includes the following components (in thousands) : December 31, 2021 2020 Domestic $ ( 32,608 ) $ ( 53,412 ) Foreign — — Loss before income taxes $ ( 32,608 ) $ ( 53,412 ) Provision for Income Taxes The provision for income taxes consisted of the following (in thousands) . December 31, 2021 2020 Current: Federal $ — $ — State 1 1 Total current 1 1 Total deferred — — Provision for income taxes $ 1 $ 1 A reconciliation of the provision for income taxes computed using the U.S. statutory federal income tax rate compared to the income tax provision included in the statement of operations and comprehensive loss is as follows (in thousands). December 31, 2021 2020 Tax on U.S. statutory rate on income before income taxes $ ( 6,847 ) $ ( 11,217 ) State taxes ( 5,405 ) 1 State valuation allowance 5,405 — Federal valuation allowance 6,600 10,986 Tax credits — 122 Other 248 109 Provision for income taxes $ 1 $ 1 Deferred Tax Assets and Liabilities Deferred tax assets and liabilities are determined based on the differences between financial reporting and income tax bases of assets and liabilities, as well as net operating loss carryforwards and are measured using the enacted tax rates and laws in effect when the differences are expected to reverse. The significant components of the Company’s net deferred tax assets and liabilities are as follows (in thousands) . December 31, 2021 2020 Deferred tax assets: Federal and state NOL carryforward $ 17,469 $ 9,681 Research and other credits 2,671 2,652 Fixed assets 15 25 Reserves and accruals 947 554 Stock based compensation 535 119 Other intangibles 12,589 8,019 Other DTA 266 — Total gross DTA 34,492 21,050 Less: valuation allowance ( 34,492 ) ( 21,050 ) Total deferred tax assets — — Deferred tax liabilities — — Net deferred tax assets $ — $ — As of December 31, 2021, the Company has federal and state net operating loss carryforwards of $ 67.8 million and $ 35.7 million, respectively, of which $ 0.1 million of federal net operating loss carryforwards and $ 0.3 million of state net operating carryforwards will begin expiring in the year 2032 and 2036 , respectively, if not utilized. The Company also has $ 57.6 million of federal net operating loss carryforwards as of December 31, 2021 that does not expire as a result of recent tax law changes. The Company has $ 2.4 million and $ 0.9 million of federal and state research and development tax credit carryforwards, which will begin to expire in the year of 2037 and 2032, respectively. Utilization of the federal and state net operating loss and tax credit carryforwards may be subject to a substantial annual limitation due to the “change in ownership” provisions of the Internal Revenue Code of 1986. The annual limitation may result in the expiration of net operating losses and credits before utilization. The Company has not performed an analysis to determine if such ownership changes have occurred. An analysis will be performed prior to recognizing the benefits of any losses or credits in the financial statements. Management assesses the available positive and negative evidence to estimate if sufficient future taxable income will be generated to use the existing deferred tax assets. Based on the weight of all evidence including a history of operating losses, management has determined that it is not more likely than not that the net deferred tax assets will be realized. A valuation allowance of $ 34.5 million and $ 21.1 million for the year ended December 31, 2021 and 2020 has been established to offset the deferred tax assets as realization of such assets is uncertain. Uncertain Tax Benefits The Company has the following activity relating to the gross amount of unrecognized tax benefits (in thousands) : Year Ended December 31, 2021 2020 Beginning balance $ 663 $ 651 Additions based on tax positions related to prior year — 19 Decreases based on tax positions related to prior year ( 97 ) ( 120 ) Additions based on tax positions related to current year 102 113 Ending balance $ 668 $ 663 None of these uncertain tax positions will impact the Company's effective tax rate if assessed. The Company's policy is to classify interest and penalties associated with unrecognized tax benefits as income tax expense. The Company had no interest or penalty accruals associated with uncertain tax benefits in its balance sheet and statement of operations for the years ended December 31, 2021 and 2020. The Company files income tax returns in the U.S. and California. The Company is not currently under examination by any major tax jurisdictions nor has it been in the past. Because of net operating losses and research credit carryovers, substantially all of our tax years remain open to examination. Although it is reasonably possible that certain unrecognized tax benefits may increase or decrease within the next 12 months due to tax examination changes, settlement activities, expirations of statute of limitations, or the impact on recognition and measurement considerations related to the results of published tax cases or other similar activities, the Company does not anticipate any significant changes to unrecognized tax benefits over the next 12 months. The Company accounts for income taxes in accordance with authoritative accounting guidance which states the impact of an uncertain income tax position is recognized at the largest amount that is “more likely than not” to be sustained upon audit by the relevant taxing authority. An uncertain tax position will not be recognized if it has less than a 50% likelihood of being sustained. As of December 31, 2021 and 2020, the Company had no material unrecognized tax benefits. No significant interest or penalties were recorded during the years ended December 31, 2021 and 2020. |
Commitments and Contingencies
Commitments and Contingencies | 12 Months Ended |
Dec. 31, 2021 | |
Commitments And Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | 14. COMMITMENTS AND CONTINGENCIES The aggregate future minimum lease payments for operating leases as of December 31, 2021, are as follows (in thousands). Operating (1) Sublease 2022 $ 2,669 $ 1,901 2023 2,755 1,964 2024 2,818 2,029 2025 1,954 1,569 Total payments $ 10,196 $ 7,463 (1) Future minimum lease payments include repayment of outstanding restructuring liabilities. Facilities Leases In April 2015, PNAi entered a lease for approximately 3,800 square feet of office and laboratory space for a term of 39 months in Woburn, Massachusetts. In January 2018, the Company elected to renew this lease for three years , beginning in August 2018. This lease expired in July 2021. In April 2018, the Company entered into the South San Francisco lease for approximately 24,606 square feet of office and life science research space, which commenced on October 1, 2018, when the Company obtained control of the rented space for a term of 84 months. In connection with the South San Francisco Lease, the Company maintains a letter of credit issued to the lessor in the amount of $ 0.3 million, which is secured by restricted cash that is classified as noncurrent based on the term of the underlying lease. The Company’s total future minimum commitment due pursuant to the South San Francisco Lease is $ 9.3 million as of December 31, 2021. In November 2020, the Company entered into a non-cancellable sublease agreement for the facility, under the terms of which the Company is entitled to receive $ 7,925 in sublease payments over the term of the sublease, which ends concurrently with the original lease in September 2025. As tenant, the Company remains responsible for the $ 9.3 million minimum lease commitment on the facilities. In November 2021, the Company entered a lease for approximately 4,900 square feet of office space for a term of 36 months in Brisbane, California. The base rent is approximately $ 0.3 million for the first year with scheduled annual 3 % increases. The lease includes renewal options for the Company. The Company recorded rent expense totaling $ 2.1 million and $ 24,000 for the years ended December 31, 2020 and 2021, respectively. Equipment Lease The Company had certain leases on research and laboratory equipment which were assigned to a certain third party as of December 31, 2021 . The Company recorded equipment rent expense totaling $ 0.3 million for the year ended December 31, 2020 . No equipment rent expense was recorded for the year ended December 31, 2021 . |
Restructuring and Related Activ
Restructuring and Related Activities | 12 Months Ended |
Dec. 31, 2021 | |
Restructuring And Related Activities [Abstract] | |
Restructuring and Related Activities | 15. RESTRUCTURING AND RELATED ACTIVITIES During the year ended December 31, 2019, the Company completely vacated its leased facilities in Woburn, Massachusetts. In connection with vacating the leased spaces, the Company recorded a discounted lease-related restructuring liability, which was calculated as the present value of the estimated future facility costs for which the Company would obtain no future economic benefit over the term of the lease, reduced for actual or estimated sublease rentals. In July 2020, the Company initiated a restructuring plan to reduce operating expense as a result of the disposal of PNAi technology. The restructuring plan included reducing the number of employees, vacating leased facilities, and ceasing use of leased equipment. As a result of this restructuring plan, the Company completely vacated its leased facilities in South San Francisco, California, which was subleased to a third party in November 2020, and returned certain leased equipment to the lessor. The Company recorded a discounted lease-related restructuring liability of $ 2.2 million and $ 0.8 million for the abandonment of the leased facilities and equipment, which was calculated as the present value of the estimated future lease costs for which the Company would obtain no future economic benefit over the term of the leases. In addition, the Company recognized restructuring liability of $ 0.3 million related to severance and other employee termination costs related to the reduction in the number of employees. The activity related to the restructuring liabilities for the year ended December 31, 2021, is as follows (in thousands) . Lease - related Employee Total Balance as of December 31, 2020 $ 2,584 $ 12 $ 2,596 Accretion 145 — 145 Provision 28 — 28 Cash payments ( 987 ) ( 12 ) ( 999 ) Lease assignment to NeuBase ( 136 ) — ( 136 ) Balance as of December 31, 2021 $ 1,634 $ — $ 1,634 |
Net Loss Per Share Attributable
Net Loss Per Share Attributable To Common Stockholders | 12 Months Ended |
Dec. 31, 2021 | |
Earnings Per Share [Abstract] | |
Net Loss Per Share Attributable To Common Stockholders | 16. NET LOSS PER SHARE ATTRIBUTABLE TO COMMON STOCKHOLDERS The following outstanding potentially dilutive shares were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods presented, because including them would have been anti-dilutive (on an as-converted basis). Year Ended December 31, 2021 2020 Redeemable convertible preferred stock — 15,774,014 Class A common stock options issued and outstanding 2,924,521 1,855,507 Unvested restricted stock awards — 41,363 Total 2,924,521 17,670,884 |
Related Party Transactions
Related Party Transactions | 12 Months Ended |
Dec. 31, 2021 | |
Related Party Transactions [Abstract] | |
Related Party Transactions | 17. RELATED PARTY TRANSACTIONS In October 2018, the Company entered into a sublease agreement for a portion of its South San Francisco office space, the term for which commenced on December 7, 2018. The Chief Executive Officer of the sublessor is a member of the Company’s board of directors. The initial sublease was established for approximately 400 square feet of space. Prior to the initial expiration of the sublease in April 2019, the space was expanded to approximately 3,700 square feet with the term of the lease extended for an additional two years . The monthly rent charged by the Company to the subtenant is subject to escalating rent payments according to the terms of the Company’s lease agreement, and the subtenant is required to reimburse the Company for monthly facility operating expenses based on its proportionate share of total square footage pursuant to the lease. The Company’s lease agreement provides that 50 % of any profit resulting from the excess of the amount collected from the subtenant less the sum of monthly rent, operating expenses and reimbursement of direct expenditures made by the Company in order to arrange and maintain the sublease is to be shared with the lessor. To date, no profit has been realized on the sublease arrangement as the monthly collections from the subtenant are equivalent to the Company’s cost of rent, operating expense and recovery of professional fees to arrange the sublease. In June 2020, the sublease agreement was terminated. During the year ended December 31, 2020, the Company recognized $ 0.2 million of sublease income under this agreement, which was recorded as a reduction to the Company’s rent expense. In October 2020, the Company entered into the Ares Agreement with Ares, pursuant to which the Company obtained an exclusive worldwide license to certain patents and related know-how to research, develop, manufacture, use and commercialize therapeutic products containing atacicept, a recombinant fusion protein used to inhibit B cell growth and differentiation, which could potentially treat some autoimmune diseases (See Note 3 and Note 12). |
Subsequent Event
Subsequent Event | 12 Months Ended |
Dec. 31, 2021 | |
Subsequent Events [Abstract] | |
Subsequent Event | 18. SUBSEQUENT EVENT On February 14, 2022, the Company completed a follow-on public offering pursuant to which the Company issued and sold 5,742,026 shares of its Class A common stock at an offering price of $ 15.00 per share, including 748,959 shares of Class A common stock to underwriters to exercise the underwriters' option to purchase additional shares. On February 9, 2022, the Company's registration statement on Form S-1 for a public offering was declared effective by the SEC. The Company received total net proceeds of approximately $ 80.2 million, after deducting underwriting discounts and commissions of $ 5.2 million, and offering costs of approximately $ 0.8 million, of which $ 0.3 million was incurred as of December 31, 2021. |
Summary of Significant Accoun_2
Summary of Significant Accounting Policies (Policies) | 12 Months Ended |
Dec. 31, 2021 | |
Accounting Policies [Abstract] | |
Basis of Presentation | Basis of Presentation The accompanying financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (GAAP) and applicable rules and regulations of the SEC regarding financial reporting. The U.S. dollar is the Company’s functional and reporting currency. |
Emerging Growth Company Status | Emerging Growth Company Status The Company is an emerging growth company as defined in the Jumpstart Our Business Startups Act of 2012 (JOBS Act). Under the JOBS Act, emerging growth companies can delay adopting new or revised accounting standards issued subsequent to the enactment of the JOBS Act until such time as those standards apply to private companies. The Company has elected to use this extended transition period for complying with certain new or revised accounting standards that have different effective dates for public and private companies until the earlier of the date that it (1) is no longer an emerging growth company or (2) affirmatively and irrevocably opts out of the extended transition period provided in the JOBS Act. As a result, these financial statements may not be comparable to companies that comply with the new or revised accounting pronouncements as of public company effective dates. |
Use of Estimates | Use of Estimates The preparation of the Company’s financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. Management estimates that affect the reported amounts of assets and liabilities include the accrual of research and development expenses, restructuring liabilities, fair value of common stock and stock-based compensation expense, and the valuation allowance for deferred tax assets. The Company evaluates and adjusts its estimates and assumptions on an ongoing basis using historical experience and other factors. Actual results could differ materially from those estimates. |
Deferred Offering Costs | Deferred Offering Costs Deferred offering costs consisting of legal, accounting and filing fees relating to the IPO are capitalized. The deferred offering costs were offset against the Company’s IPO proceeds upon the closing of the IPO. |
Concentrations of Credit Risk and Other Risks and Uncertainties | Concentrations of Credit Risk and Other Risks and Uncertainties Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash and cash equivalents. The Company maintains bank deposits in a federally insured financial institution and these deposits may exceed federally insured limits. The Company is exposed to credit risk in the event of default by the financial institution holding its cash and cash equivalents to the extent recorded in the balance sheet. The Company has not experienced any losses on its deposits of cash and cash equivalents. The Company’s future results of operations involve a number of other risks and uncertainties. Factors that could affect the Company’s future operating results and cause actual results to vary materially from expectations include, but are not limited to, uncertainty of results of clinical trials and reaching milestones, uncertainty of regulatory approval of the Company’s current and potential future product candidates, uncertainty of market acceptance of the Company’s product candidates, competition from substitute products and larger companies, securing and protecting proprietary technology, strategic relationships and dependence on key individuals or sole-source suppliers. The Company’s product candidates require approvals from the U.S. Food and Drug Administration and comparable foreign regulatory agencies prior to commercial sales in their respective jurisdictions. There can be no assurance that any product candidates will receive the necessary approvals. If the Company was denied approval, approval was delayed, or the Company was unable to maintain approval for any product candidate, it could have a materially adverse impact on the Company. |
Impact of the COVID-19 Pandemic | Impact of the COVID-19 Pandemic The COVID-19 pandemic continues to evolve. The extent of the impact of the COVID-19 pandemic on the Company’s business, operations, and development timelines and plans remains uncertain, and will depend on certain developments, including the duration and spread of the outbreak and its impact on the Company’s development activities, planned clinical trial enrollment, future trial sites, contract research organizations, third-party manufacturers, and other third parties with whom the Company does business, as well as its impact on regulatory authorities and the Company’s key scientific and management personnel. The ultimate impact of the COVID-19 pandemic or a similar health epidemic is highly uncertain and subject to change. To the extent possible, the Company is conducting business as usual, with necessary or advisable modifications to employee travel and with the Company’s employees mostly working remotely. The Company will continue to actively monitor the evolving situation related to the COVID-19 pandemic and may take further actions that alter the Company’s operations, including those that may be required by federal, state or local authorities, or that the Company determines are in the best interests of its employees and other third parties with whom the Company does business. At this point, the extent to which the COVID-19 pandemic may affect the Company’s business, operations and development timelines and plans, including the resulting impact on expenditures and capital needs, remains uncertain. |
Cash and Cash Equivalents | Cash and Cash Equivalents The Company considers all highly liquid investments with an original maturity of three months or less when purchased to be cash equivalents. Cash equivalents consist of money market funds and are stated at fair value. |
Restricted Cash | Restricted Cash Restricted cash represents cash held by a financial institution as collateral for a letter of credit securing its operating lease for office and laboratory space, which is classified within current and non-current assets on the balance sheets. |
Comprehensive Loss | Comprehensive Loss Comprehensive loss consists of net loss and other gains and losses affecting redeemable convertible preferred stock and stockholders’ equity (deficit) that, under GAAP, are excluded from net loss. The Company has no items of other comprehensive loss for the year ended December 31, 2021 and 2020 . As such, net loss equals comprehensive loss. |
Research and Development Costs | Research and Development Costs Research and development costs are expensed as incurred and consist primarily of employees’ salaries and related benefits, including stock-based compensation and termination expenses for employees engaged in research and development efforts, allocated overhead including rent, depreciation, information technology and utilities, contracted services, license fees, and external expenses to conduct and support the Company’s operations that are directly attributable to the Company’s research and development efforts. Payments made to third parties under these arrangements in advance of the performance of the related services by the third parties are recorded as prepaid expenses until the services are rendered. Costs incurred in obtaining technology licenses including upfront and milestone payments incurred under the Company’s licensing agreements are recorded as expense in the period in which they are incurred, provided that the licensed technology, method or process has no alternative future uses other than for the Company’s research and development activities. Where contingent milestone payments are due to third parties under license or other agreements, the milestone payment obligations are recognized as expense when achievement of the contingent milestone is probable, which is generally upon achievement of the milestone. |
Research Contract Costs And Accruals | Research Contract Costs and Accruals The Company enters into various research and development and other agreements with commercial firms, researchers, and others for provisions of goods and services from time to time. These agreements are generally cancellable, and the related costs are recorded as research and development expenses as incurred. The Company records accruals for estimated ongoing research and development costs. When evaluating the adequacy of the accrued liabilities, the Company analyzes progress of the studies or clinical trials, including the phase or completion of events, invoices received and contracted costs. These expenses and accrued liabilities are adjusted as actual expenses become known. Significant judgments and estimates are made in determining the accrued balances at the end of any reporting period. Actual results could differ materially from the Company’s estimates. |
Redeemable Convertible Preferred Stock | Redeemable Convertible Preferred Stock The Company records all shares of redeemable convertible preferred stock at their respective fair values on the dates of issuance, net of issuance costs. The carrying value of the Company’s redeemable convertible preferred stock is adjusted to reflect dividends if and when declared by the Company’s board of directors. No dividends have been declared by the board of directors since inception. The Company classifies its redeemable convertible preferred stock separate from total stockholders’ equity (deficit), as the redemption of such stock is not solely under the control of the Company. |
Stock-Based Compensation | Stock-Based Compensation The Company recognizes compensation expense based on estimated fair values for all stock-based payment awards made to the Company’s employees, nonemployee directors and consultants that are expected to vest. The valuation of stock option awards is determined at the date of grant using the Black-Scholes option pricing model. The Black-Scholes option pricing model requires the Company to make assumptions and judgements about the inputs used in the calculations, such as the fair value of the common stock, expected term, expected volatility of the Company’s common stock, risk-free interest rate and expected dividend yield. The valuation of restricted stock awards is measured by the fair value of the Company’s common stock on the date of the grant. For all stock options granted, the Company calculated the expected term using the simplified method (derived from the average midpoint between the weighted average vesting period and the contractual term of the award) for “plain vanilla” stock option awards, as the Company has limited historical information to develop expectations about future exercise patterns and post vesting employment termination behavior. The estimate of expected volatility is based on comparative companies’ volatility. The risk-free rate is based on the yield available on United States Treasury zero-coupon issues corresponding to the expected term of the award. The Company records forfeitures when they occur. Prior to the completion of our initial public offering, the fair value of the shares of common stock underlying the stock options was determined by the board of directors with the assistance of management and input from an independent third-party valuation firm, as there was no public market for the common stock. The board of directors determined the fair value of the Company’s common stock by considering a number of objective and subjective factors, including the valuation of comparable companies, sales of redeemable convertible preferred stock, the Company’s operating and financial performance, the lack of liquidity of common stock, and general and industry specific economic outlook, amongst other factors. The Company records compensation expense for service-based awards on a straight-line basis over the requisite service period, which is generally the vesting period of the award. The amount of stock-based compensation expense recognized during a period is based on the value of the portion of the awards that are ultimately expected to vest. |
Income Taxes | Income Taxes Income taxes are accounted for under the asset and liability method. Deferred income taxes are recorded for temporary differences between financial statement carrying amounts and the tax basis of assets and liabilities. Deferred tax assets and liabilities reflect tax rates expected to be in effect for the years in which the differences are expected to be reversed. A valuation allowance is provided if it is more likely than not that some or all of the deferred tax assets will not be realized. |
Net Loss Per Share Attributable to Common Stockholders | Net Loss Per Share Attributable to Common Stockholders Net loss per share of common stock is computed using the two-class method required for multiple classes of common stock and participating securities based upon their respective rights to receive dividends as if all income for the period has been distributed. The rights, including the liquidation and dividend rights and sharing of losses, of the Class A and Class B common stock are identical, other than voting rights. As the liquidation and dividend rights and sharing of losses are identical, the undistributed earnings are allocated on a proportionate basis and the resulting net loss per share attributed to common stockholders is therefore the same for Class A and Class B common stock on an individual or combined basis. The Company’s participating securities include the Company’s redeemable convertible preferred stock, as the holders were entitled to receive noncumulative dividends on a pari passu basis in the event that a dividend is paid on common stock. The Company also considers any shares issued on the early exercise of stock options subject to repurchase to be participating securities because holders of such shares have non-forfeitable dividend rights in the event a dividend is paid on common stock. The holders of redeemable convertible preferred stock, as well as the holders of early exercised shares subject to repurchase, did not and do not have a contractual obligation to share in losses of the Company, and therefore during periods of loss there is no allocation required under the two-class method. Basic net loss per share attributable to common stockholders is calculated by dividing the net loss attributable to common stockholders by the weighted-average number of shares of common stock outstanding during the period, adjusted for outstanding shares that are subject to repurchase. Diluted net loss per share is computed by giving effect to all potentially dilutive securities outstanding for the period using the treasury stock method or the if-converted method based on the nature of such securities. For periods in which the Company reports net losses, diluted net loss per share attributable to common stockholders is the same as basic net loss per share attributable to common stockholders, because potentially dilutive shares are not assumed to have been issued if their effect is anti-dilutive. |
Leases | Leases The Company leases office and laboratory space under operating leases and laboratory equipment under capital leases. Leases for which the Company assumes substantially all risks and rewards incidental to ownership of the leased assets are classified as capital leases. The leased assets and the corresponding lease liabilities (net of interest charges) are recognized on the balance sheet as property and equipment, based on the cost of the equipment, and borrowings, respectively, at the inception of the related lease. Each lease payment is apportioned between the reduction of the outstanding lease liability and the related interest expense. The interest expense is recorded on a basis that reflects a constant periodic rate of interest on the outstanding finance lease liability. Leases for which substantially all risks and rewards incidental to ownership are retained by the lessors are classified as operating leases. Payments made under operating leases (net of any incentive received from the lessors) are recorded on a straight-line basis over the period of the lease. |
Restructuring Costs | Restructuring Costs Restructuring costs primarily consist of contract termination costs related to leases and employee termination costs. The Company recognizes restructuring charges when the liability has been incurred. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations, cease use date of leased property and equipment, and the timing of employees leaving the Company. Accretion expenses related to restructuring costs are included in general and administrative expenses. |
Fair Value Option | Fair Value Option The convertible notes issued in 2020, for which the Company elected the fair value option, are accounted for at fair value on a recurring basis with changes in fair value recognized in the statement of operations and comprehensive loss. Interest accrued on the convertible notes was recorded to interest expense during the periods in which the convertible notes were outstanding. |
Fair Value Measurements | Fair Value Measurements Fair value is defined as the exchange price to sell an asset or transfer a liability (exit price) in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants at the measurement date. Fair value should be based on the assumptions market participants would use when pricing the asset or liability. The valuation hierarchy is based upon the transparency of inputs to the valuation of an asset or liability as of the measurement date. Fair value measurements are classified and disclosed in one of the following three categories: Level 1 – Quoted unadjusted prices for identical instruments in active markets. Level 2 – Quoted prices for similar instruments in active markets, quoted prices for identical or similar instruments in markets that are not active, and model-derived valuations in which all observable inputs and significant value drivers are observable in active markets. Level 3 – Model derived valuations in which one or more significant inputs or significant value drivers are unobservable, including assumptions developed by the Company. The carrying amounts of the Company’s cash and cash equivalents, prepaid expenses and other current assets, accounts payable and accrued expenses approximate their fair value due to their short-term nature. The carrying amount of debt approximates fair value due to its variable interest rate. Money market funds are highly liquid investments that are actively traded. The pricing information for the Company’s money market funds are readily available and can be independently validated as of the measurement date. This approach results in the classification of these securities as Level 1 of the fair value hierarchy. The Company’s non-marketable equity securities (Note 5) are measured at fair value using an option pricing valuation methodology. The option pricing methodology relies on risk-neutral valuation which calculates the value of an asset by discounting the expected value of its future payoffs at the risk-free rate of return. The fair value of the non-marketable equity securities is derived from quoted prices for similar instruments and observable inputs in active markets. This approach results in the classification of these securities as Level 2 of the fair value hierarchy. There were no transfers between Levels 1, 2, or 3 for any of the periods presented. As of December 31, 2021 and 2020 , the Company held $ 73.8 million and $ 52.3 million, respectively, in money market funds with no unrealized gains or losses. |
Recently Adopted Accounting Pronouncements | Recently Adopted Accounting Pronouncements In December 2019, the Financial Accounting Standards Board (FASB) issued Accounting Standard Update (ASU) No. 2019-12, Income Taxes (Topic 740) , Simplifying the Accounting for Income Taxes , related to simplifying the accounting for income taxes. The guidance eliminates certain exceptions from Accounting Standards Codification (ASC) 740 related to the approach for intraperiod tax allocation, the methodology for calculating income taxes in an interim period and the recognition of deferred tax liabilities for outside basis differences. The guidance also clarifies and simplifies other aspects of the accounting for income taxes. The guidance became effective for the Company beginning on the first quarter of 2021 on a prospective basis. The Company adopted this standard on January 1, 2021, and it did not have a material impact on the Company's financial statements or related disclosures. In June 2018, the FASB issued ASU No. 2018-07, Compensation—Stock Compensation (Topic 718): Improvements to Nonemployee Share-Based Payment Accounting , to reduce cost and complexity and to improve financial reporting for share-based payments issued to nonemployees (for example, service providers, external legal counsel, suppliers, etc.). This includes allowing for the measurement of awards at the grant date and recognition of awards with performance conditions when those conditions are probable, both of which are earlier than under current guidance for nonemployee awards. The Company adopted this standard as of January 1, 2020 on a retrospective basis. The adoption of this standard did not have a material impact on its financial statements. In August 2018, the FASB issued ASU No. 2018-13, Disclosure Framework – Changes to the Disclosure Requirements for Fair Value Measurement , which amends ASC 820, Fair Value Measurement. This standard modifies the disclosure requirements for fair value measurements by removing, modifying, or adding certain disclosures. The Company adopted this standard as of January 1, 2020 on a retrospective basis. The adoption of this standard did not have a material impact on its financial statements |
Recently Issued Accounting Pronouncements | Recently Issued Accounting Pronouncements In February 2016, the FASB issued ASU No. 2016-02, Leases (Topic 842) , subsequently amended by ASU 2018-10, ASU 2018-11, ASU 2018-20, ASU 2019-01 and ASU 2019-10, which sets out the principles for the recognition, measurement, presentation and disclosure of leases for both lessors and lessees of a contract. The new standard requires lessees to apply a dual approach, classifying leases as either finance or operating leases based on the principle of whether or not the lease is effectively a financed purchase by the lessee. This classification will determine whether lease expense is recognized based on an effective interest method or on a straight-line basis over the term of the lease. A lessee is also required to record a right-of-use asset and a lease liability for all leases with a term of greater than 12 months regardless of their classification on the balance sheets. Leases with a term of 12 months or less may be accounted for similar to existing guidance for operating leases today. The Company adopted the prospective approach as of January 1, 2022. Additionally, the Company intends to use the package of available practical expedients, which allows it to (i) not reassess whether any expired or existing contracts are or contain leases; (ii) not reassess the lease classification for expired or existing leases; and (iii) not reassess the treatment of initial direct costs for any existing leases. The Company also has elected the practical expedient to not separate lease and non-lease components for all leases. The Company has substantially completed its evaluation of the effect that the adoption of this guidance will have on its financial statements. In connection with the adoption of the new guidance, the Company expects to recognize lease liabilities of approximately $ 9.0 million and right-of-use assets of approximately $ 7.0 million for operating leases, with immaterial impact to its statements of operations and cash flows. In June 2016, the FASB issued ASU 2016-13, Financial Instruments—Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments . The objective of the standard is to provide information about expected credit losses on financial instruments at each reporting date and to change how other-than temporary impairments on investment securities are recorded. The guidance is effective for the Company beginning on January 1, 2023, with early adoption permitted. The Company is currently evaluating the impact the standard may have on its financial statements and related disclosures. In March 2020, the FASB issued ASU No. 2020-04, Reference Rate Reform (Topic 848) : Facilitation of the Effects of Reference Rate Reform on Financial Reporting . In response to concerns about structural risks of the cessation of London Interbank Offered Rate (LIBOR), the amendments in this ASU provide optional guidance for a limited time to ease the potential burden in accounting for (or recognizing the effect of) reference rate reform on financial reporting. The amendments in this ASU provide optional expedients and exceptions for applying GAAP to contracts, hedging relationships and other transactions affected by reference rate reform if certain criteria are met. The expedients and exceptions provided by this amendment do not apply to contract modifications made and hedge relationships entered into or evaluated after December 31, 2022. The amendments in this ASU are elective and are effective for all entities as of March 12, 2020 through December 31, 2022. The Company continues to evaluate contractual arrangements that reference LIBOR. In August 2020, the FASB issued ASU No. 2020-06, Debt—Debt with Conversion and Other Options (Subtopic 470-20) and Derivatives and Hedging—Contracts in Entity’s Own Equity (Subtopic 815-40) . This standard simplifies the accounting for convertible debt instruments and convertible preferred stock by removing the existing guidance in ASC 470-20 that requires entities to account for beneficial conversion features and cash conversion features in equity, separately from the host convertible debt or preferred stock. ASU 2020-06 is effective for the Company for annual reporting periods, and interim reporting periods within those annual periods, beginning after December 15, 2023, and early adoption is permitted. The Company is currently evaluating the impact this standard will have on its financial statements and related disclosures. |
Non-Marketable Equity Securities | The Company reports the restricted equity securities as non-marketable equity securities on the balance sheet, and determines current or non-current classification based on the expected duration of the restriction. |
Other Financial Statement Inf_2
Other Financial Statement Information (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Other Financial Statement Information [Abstract] | |
Schedule Of Prepaid Expenses and Other Current Assets | Prepaid expenses and other current assets consist of the following (in thousands) . December 31, 2021 2020 Prepaid insurance $ 1,193 $ 27 Prepaid contract costs 320 — Prepaid follow-on financing costs 275 — Prepaid recruiting fees 253 — Prepaid rent 219 — Prepaid audit fees 123 — Deposits 57 86 Receivables from exercise of options — 52 Other 423 392 Total prepaid expenses and other current assets $ 2,863 $ 557 |
Schedule Of Accrued Expenses And Other Current Liabilities | Accrued expenses and other current liabilities consist of the following (in thousands) . December 31, 2021 2020 Accrued development milestone $ 2,000 $ — Accrued payroll 1,458 405 Related party payable 1,022 — Accrued legal fees 457 — Accrued research and development contract costs 364 — Accrued consulting fees 341 — Accrued expenses and other 286 130 Total accrued expenses and other current liabilities $ 5,928 $ 535 |
Non-Marketable Equity Securit_2
Non-Marketable Equity Securities (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Investments Debt And Equity Securities [Abstract] | |
Summary of Carrying Value of the Non-marketable Equity Securities | The carrying value of the non-marketable equity securities as of December 31, 2021, is summarized below (in thousands) . Initial cost as of April 26, 2021 $ 1,759 Change in fair value ( 892 ) Balance as of December 31, 2021 $ 867 |
Note Payable (Table)
Note Payable (Table) | 12 Months Ended |
Dec. 31, 2021 | |
Debt Disclosure [Abstract] | |
Schedule of Notes Payable | Note payable consists of the following: Rate Type Maturity Effective Interest Rate December 31, (in thousands) Collateralized note Variable 2026 9.53 % $ 5,000 Less: Debt issuance costs ( 77 ) Net carrying amount of debt $ 4,923 |
Schedule Principal Installments Due | Principal installments due on the note subsequent to December 31, 2021 are as follows (in thousands) : 2022 $ — 2023 — 2024 — 2025 — 2026 5,000 Total accrued expenses and other current liabilities $ 5,000 |
Redeemable Convertible Prefer_2
Redeemable Convertible Preferred Stock (Table) | 12 Months Ended |
Dec. 31, 2021 | |
Temporary Equity [Abstract] | |
Summary of Redeemable Convertible Preferred Stock | As of December 31, 2020, the Company’s redeemable convertible preferred stock consisted of the following balances. ISSUE PRICE SHARES SHARES ISSUED CARRYING AGGREGATE (in thousands) (in thousands) Series Seed $ 1.01 1,010,456 1,010,456 $ 1,789 $ 1,020 Series Seed-1 1.92 1,787,640 1,787,640 3,718 3,430 Series A 2.15 6,120,111 6,120,111 12,851 13,136 Series B 4.29 5,097,566 5,097,566 21,737 21,882 Series C 0.59 168,756,599 168,756,599 99,481 99,870 Total 182,772,372 182,772,372 $ 139,576 $ 139,338 |
Stock Compensation (Table)
Stock Compensation (Table) | 12 Months Ended |
Dec. 31, 2021 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Summary of Share-based Compensation Arrangements by Share-based Payment Award | Stock option activity under the 2017 EIP and 2021 EIP was as follows: NUMBER OF WEIGHTED- WEIGHTED- AGGREGATE Outstanding as of December 31, 2020 1,855,507 $ 2.99 9.79 $ 8 Granted 1,217,914 9.36 Exercised ( 145,805 ) 3.77 Cancelled and forfeited ( 3,095 ) 9.39 Outstanding as of December 31, 2021 2,924,521 5.62 9.11 $ 61,712 Options exercisable as of 467,621 3.01 8.91 $ 11,089 Vested and expected to vest as of 2,924,521 $ 5.62 9.11 $ 61,712 |
Summary of Share-based Payment Arrangement, Expensed and Capitalized, Amount | The following tables summarize the stock-based compensation expense for stock options and restricted stock awards granted to employees and nonemployees that was recorded in the Company’s statements of operations and comprehensive loss for the year ended December 31, 2021 and 2020 (in thousands) . Year Ended December 31, 2021 2020 Research and development $ 915 $ 4 General and administrative 2,097 327 Total stock-based compensation expense $ 3,012 $ 331 Year Ended December 31, 2021 2020 Employees $ 2,605 $ 321 Nonemployees 407 10 Total stock-based compensation expense $ 3,012 $ 331 |
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions | The fair value of stock options granted during the year ended December 31, 2021 and 2020 was estimated using the Black-Scholes option pricing model based on the following weighted average assumptions. Year Ended December 31, 2021 2020 Expected term (in years) 5.5 – 6.1 5.5 – 6.1 Expected volatility 75.4 % – 76.8 % 86.1 % – 92.5 % Risk-free rate 0.6 % – 1.3 % 0.41 % – 1.67 % Dividend yield — — |
Summary of Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity | The following table summarizes the activity for the Company’s restricted stock for the year ended December 31, 2021. NUMBER OF SHARES Unvested as of December 31, 2020 41,363 Vested ( 41,363 ) Unvested as of December 31, 2021 — |
Income Taxes (Tables)
Income Taxes (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Income Tax Disclosure [Abstract] | |
Schedule of Income (loss) Before Provision for Income Taxes | For financial reporting purposes, income (loss) before provision for income taxes, includes the following components (in thousands) : December 31, 2021 2020 Domestic $ ( 32,608 ) $ ( 53,412 ) Foreign — — Loss before income taxes $ ( 32,608 ) $ ( 53,412 ) |
Schedule of Components of Provision for Income Taxes | The provision for income taxes consisted of the following (in thousands) . December 31, 2021 2020 Current: Federal $ — $ — State 1 1 Total current 1 1 Total deferred — — Provision for income taxes $ 1 $ 1 |
Schedule of reconciliation of the provision for income taxes | A reconciliation of the provision for income taxes computed using the U.S. statutory federal income tax rate compared to the income tax provision included in the statement of operations and comprehensive loss is as follows (in thousands). December 31, 2021 2020 Tax on U.S. statutory rate on income before income taxes $ ( 6,847 ) $ ( 11,217 ) State taxes ( 5,405 ) 1 State valuation allowance 5,405 — Federal valuation allowance 6,600 10,986 Tax credits — 122 Other 248 109 Provision for income taxes $ 1 $ 1 |
Summary of Deferred Tax Assets and Liabilities | The significant components of the Company’s net deferred tax assets and liabilities are as follows (in thousands) . December 31, 2021 2020 Deferred tax assets: Federal and state NOL carryforward $ 17,469 $ 9,681 Research and other credits 2,671 2,652 Fixed assets 15 25 Reserves and accruals 947 554 Stock based compensation 535 119 Other intangibles 12,589 8,019 Other DTA 266 — Total gross DTA 34,492 21,050 Less: valuation allowance ( 34,492 ) ( 21,050 ) Total deferred tax assets — — Deferred tax liabilities — — Net deferred tax assets $ — $ — |
Summary of Activity Relating to Gross Amount of Unrecognized Tax Benefits | The Company has the following activity relating to the gross amount of unrecognized tax benefits (in thousands) : Year Ended December 31, 2021 2020 Beginning balance $ 663 $ 651 Additions based on tax positions related to prior year — 19 Decreases based on tax positions related to prior year ( 97 ) ( 120 ) Additions based on tax positions related to current year 102 113 Ending balance $ 668 $ 663 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Commitments And Contingencies Disclosure [Abstract] | |
Summary of Future Minimum Lease Payments For Operating Leases | The aggregate future minimum lease payments for operating leases as of December 31, 2021, are as follows (in thousands). Operating (1) Sublease 2022 $ 2,669 $ 1,901 2023 2,755 1,964 2024 2,818 2,029 2025 1,954 1,569 Total payments $ 10,196 $ 7,463 (1) Future minimum lease payments include repayment of outstanding restructuring liabilities. |
Restructuring and Related Act_2
Restructuring and Related Activities (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Restructuring And Related Activities [Abstract] | |
Summary of Activity Related To The Restructuring Liabilities | The activity related to the restructuring liabilities for the year ended December 31, 2021, is as follows (in thousands) . Lease - related Employee Total Balance as of December 31, 2020 $ 2,584 $ 12 $ 2,596 Accretion 145 — 145 Provision 28 — 28 Cash payments ( 987 ) ( 12 ) ( 999 ) Lease assignment to NeuBase ( 136 ) — ( 136 ) Balance as of December 31, 2021 $ 1,634 $ — $ 1,634 |
Net Loss Per Share Attributab_2
Net Loss Per Share Attributable To Common Stockholders (Tables) | 12 Months Ended |
Dec. 31, 2021 | |
Earnings Per Share [Abstract] | |
Summary of Dilutive Shares Excluded From Computation of Diluted Net Loss Per Share | The following outstanding potentially dilutive shares were excluded from the computation of diluted net loss per share attributable to common stockholders for the periods presented, because including them would have been anti-dilutive (on an as-converted basis). Year Ended December 31, 2021 2020 Redeemable convertible preferred stock — 15,774,014 Class A common stock options issued and outstanding 2,924,521 1,855,507 Unvested restricted stock awards — 41,363 Total 2,924,521 17,670,884 |
Organization and Description _2
Organization and Description of the Business - Additional Information (Detail) $ / shares in Units, $ in Thousands | May 20, 2021USD ($)shares | May 13, 2021$ / sharesshares | May 07, 2021 | May 31, 2021shares | Dec. 31, 2021USD ($)shares | Dec. 31, 2020USD ($) |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Stock split ratio | 11.5869 | |||||
Underwriting discounts and commissions | $ | $ 3,900 | |||||
Offering costs | $ | 2,800 | |||||
Accumulated deficit | $ | $ 124,056 | $ 91,447 | ||||
Cash and cash equivalents | $ | $ 79,674 | $ 53,654 | ||||
Common Class A | ||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Stock shares issued during the period new issues shares | shares | 5,002,500 | |||||
Common Class A | Conversion Of Redeemable Preferred Stock Into Common Stock [Member] | ||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Conversion of redeemable convertible preferred stock to common stock | shares | 15,464,776 | |||||
Common Class A | IPO [Member] | ||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Stock shares issued during the period new issues shares | shares | 4,350,000 | |||||
Sale of stock, price per share | $ / shares | $ 11 | |||||
Sale of stock net consideration received on the transaction | $ | $ 48,400 | |||||
Common Class A | Over-Allotment Option | ||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Stock shares issued during the period new issues shares | shares | 652,500 | |||||
Common Class B [Member] | Conversion Of Redeemable Preferred Stock Into Common Stock [Member] | ||||||
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] | ||||||
Conversion of redeemable convertible preferred stock to common stock | shares | 309,238 |
Summary of Significant Accoun_3
Summary of Significant Accounting Policies - Additional Information (Detail) - USD ($) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Accounting Policies [Line Items] | ||
Right-of-use asset | $ 7,000,000 | |
Operating Lease, Right-of-Use Asset, Statement of Financial Position [Extensible Enumeration] | Prepaid Expense and Other Assets, Noncurrent | |
Operating Lease, Liability | $ 9,000,000 | |
Operating Lease, Liability, Statement of Financial Position [Extensible Enumeration] | us-gaap:OtherLiabilitiesNoncurrent | |
Money Market Funds [Member] | ||
Accounting Policies [Line Items] | ||
Money market funds | $ 73,800,000 | $ 52,300,000 |
Gain loss on securities unrealized | $ 0 | $ 0 |
Other Financial Statement Inf_3
Other Financial Statement Information - Schedule Of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Other Financial Statement Information [Abstract] | ||
Prepaid insurance | $ 1,193 | $ 27 |
Prepaid contract costs | 320 | |
Prepaid follow-on financing costs | 275 | |
Prepaid recruiting fees | 253 | |
Prepaid Rent | 219 | |
Prepaid audit fee | 123 | |
Deposits | 57 | 86 |
Receivables from exercise of options | 52 | |
Other | 423 | 392 |
Total prepaid expenses and other current assets | $ 2,863 | $ 557 |
Other Financial Statement Inf_4
Other Financial Statement Information - Schedule Of Accrued Expenses And Other Current Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Other Financial Statement Information [Abstract] | ||
Accrued development milestone | $ 2,000 | |
Accrued payroll | 1,458 | $ 405 |
Related party payable | 1,022 | |
Accrued Legal fees | 457 | |
Accrued consulting fees | 364 | |
Accrued research and development contract costs | 341 | |
Accrued expenses and other | 286 | 130 |
Total accrued expenses and other current liabilities | $ 5,928 | $ 535 |
Neubase Asset Sale - Additional
Neubase Asset Sale - Additional Information (Detail) - USD ($) | Apr. 26, 2021 | Dec. 31, 2021 |
Proceeds from sale of PNAi technology | $ 796,000 | |
Gain (Loss) on Disposition of Assets | 2,700,000 | |
Neubase Therapeutics Inc [Member] | ||
Investment owned number of shares placed in escrow account | 162,260 | |
Shares eligible for release from escrow | $ 54,070,000 | |
Neubase Therapeutics Inc [Member] | Investment In PNAI [Member] | ||
Proceeds from sale of PNAi technology | $ 800,000 | |
Disposal group including discontinued operations shares received for disposal | 308,635 | |
Investments owned market value | $ 1,800,000 |
Non-Marketable Equity Securit_3
Non-Marketable Equity Securities - Additional Information (Detail) - USD ($) $ in Thousands | 8 Months Ended | 12 Months Ended |
Dec. 31, 2021 | Dec. 31, 2021 | |
Marketable Securities [Line Items] | ||
Equity Securities, FV-NI, Unrealized Gain (Loss) | $ (892) | $ (892) |
Other Expense | ||
Marketable Securities [Line Items] | ||
Equity Securities, FV-NI, Unrealized Gain (Loss) | $ 900 |
Non-Marketable Equity Securit_4
Non-Marketable Equity Securities - Summary of Carrying Value of the Non-marketable Equity Securities (Detail) - USD ($) $ in Thousands | 8 Months Ended | 12 Months Ended |
Dec. 31, 2021 | Dec. 31, 2021 | |
Investments Debt And Equity Securities [Abstract] | ||
Initial cost as of April 26, 2021 | $ 1,759 | |
Change in fair value | (892) | $ (892) |
Balance as of December 31, 2021 | $ 867 | $ 867 |
Note Payable - Schedule of Note
Note Payable - Schedule of Notes Payable (Detail) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Debt Disclosure [Abstract] | ||
Collateralized note , variable | Variable | |
Collateralized debt instrument maturity date. | 2026 | |
Collateralized note , Effective interest rate | 9.53% | |
Collateralized note ,Amount | $ 5,000 | |
Less: Debt issuance costs | 77 | |
Net carrying amount of debt | $ 4,923 | $ 0 |
Note Payable - Additional Infor
Note Payable - Additional Information (Detail) - USD ($) | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2022 | Dec. 31, 2020 | |
Line of Credit Facility [Line Items] | |||
Carrying amount of debt outstanding | $ 5,000,000 | $ 0 | |
Revolving Credit Facility [Member] | |||
Line of Credit Facility [Line Items] | |||
Revolving credit facility with borrowing capacity | 50,000,000 | ||
Initial borrowing capacity | $ 5,000,000 | ||
Additional borrowing capacity | $ 45,000,000 | ||
Debt facility payments description | The debt facility provides for at least 48-months of interest-only payments, which may be extended to 60 months | ||
Prepayment of the loan | 5.00% | ||
Extended maturity date | 7.00% | ||
Revolving Credit Facility [Member] | LIBOR [Member] | |||
Line of Credit Facility [Line Items] | |||
Floating interest rate | 8.25% |
Note Payable - Schedule Princip
Note Payable - Schedule Principal Installments Due (Detail) - USD ($) | Dec. 31, 2021 | Dec. 31, 2020 |
Debt Disclosure [Abstract] | ||
2026 | $ 5,000,000 | |
Total accrued expenses and other current liabilities | $ 5,000,000 | $ 0 |
Convertible Notes - Additional
Convertible Notes - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions | 1 Months Ended | |||
Oct. 31, 2020 | Dec. 31, 2020 | May 31, 2020 | Mar. 31, 2020 | |
Series C [Member] | ||||
Debt Instrument [Line Items] | ||||
Temporary equity original issuance price | $ 0.59 | |||
Convertible Notes [Member] | ||||
Debt Instrument [Line Items] | ||||
Debt instrument Principal amount | $ 5 | |||
Debt instrument fixed interest rate percentage | 4.00% | |||
Convertible Notes [Member] | Additional Convertible Notes Issued [Member] | ||||
Debt Instrument [Line Items] | ||||
Debt instrument Principal amount | $ 0.6 | |||
Convertible Notes [Member] | Series B redeemable convertible stock [Member] | ||||
Debt Instrument [Line Items] | ||||
Debt conversion convertible instrument percent | 85.00% | |||
Debt instrument convertible price per share | $ 4.2926 | |||
Convertible Notes [Member] | Series C [Member] | ||||
Debt Instrument [Line Items] | ||||
Debt conversion convertible instrument percent | 85.00% | |||
Debt instrument convertible price per share | $ 0.5030 | |||
Debt outstanding converted instrument amount | $ 0.1 | |||
Debt instrument converted shares issued | 11,404,246 | |||
Temporary equity original issuance price | $ 0.5918 |
Redeemable Convertible Prefer_3
Redeemable Convertible Preferred Stock - Summary of Redeemable Convertible Preferred Stock (Detail) - USD ($) $ / shares in Units, $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Temporary Equity [Line Items] | ||
Temporary equity shares authorized | 0 | 182,772,372 |
Temporary equity shares issued | 0 | 182,772,372 |
Temporary equity shares outstanding | 0 | 182,772,372 |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 0 | $ 139,576 |
Temporary Equity, Liquidation Preference | $ 139,338 | |
Series Seed [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity original issuance price | $ 1.01 | |
Temporary equity shares authorized | 1,010,456 | |
Temporary equity shares issued | 1,010,456 | |
Temporary equity shares outstanding | 1,010,456 | |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 1,789 | |
Temporary Equity, Liquidation Preference | $ 1,020 | |
Series Seed-1 [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity original issuance price | $ 1.92 | |
Temporary equity shares authorized | 1,787,640 | |
Temporary equity shares issued | 1,787,640 | |
Temporary equity shares outstanding | 1,787,640 | |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 3,718 | |
Temporary Equity, Liquidation Preference | $ 3,430 | |
Series A [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity original issuance price | $ 2.15 | |
Temporary equity shares authorized | 6,120,111 | |
Temporary equity shares issued | 6,120,111 | |
Temporary equity shares outstanding | 6,120,111 | |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 12,851 | |
Temporary Equity, Liquidation Preference | $ 13,136 | |
Series B [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity original issuance price | $ 4.29 | |
Temporary equity shares authorized | 5,097,566 | |
Temporary equity shares issued | 5,097,566 | |
Temporary equity shares outstanding | 5,097,566 | |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 21,737 | |
Temporary Equity, Liquidation Preference | $ 21,882 | |
Series C [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity original issuance price | $ 0.59 | |
Temporary equity shares authorized | 168,756,599 | |
Temporary equity shares issued | 168,756,599 | |
Temporary equity shares outstanding | 168,756,599 | |
Redeemable Noncontrolling Interest Equity Preferred Carrying Amount | $ 99,481 | |
Temporary Equity, Liquidation Preference | $ 99,870 |
Redeemable Convertible Prefer_4
Redeemable Convertible Preferred Stock - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Millions | 1 Months Ended | |
May 31, 2021 | Oct. 31, 2020 | |
Common Stock [Member] | Covertible Preferred Stock [Member] | ||
Temporary Equity [Line Items] | ||
Conversion of preferred stock into common stock, Shares | 15,774,014 | |
Series C [Member] | ||
Temporary Equity [Line Items] | ||
Number of redeemable convertible preferred stock shares issued | 135,180,800 | |
Temporary equity purchase price per share | $ 0.5918 | |
Proceeds from redeemable convertible preferred stock | $ 80 | |
Series C [Member] | Convertible Notes [Member] | ||
Temporary Equity [Line Items] | ||
Temporary equity purchase price per share | $ 0.5918 | |
Debt instrument converted shares issued | 11,404,246 | |
Debt instrument convertible price per share | $ 0.5030 | |
Debt conversion convertible instrument percent | 85.00% | |
Series C [Member] | Ares [Member] | ||
Temporary Equity [Line Items] | ||
Number of redeemable convertible preferred stock shares issued | 22,171,553 |
Common Stock - Additional Infor
Common Stock - Additional Information (Detail) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Common Class A | ||
Class Of Stock [Line Items] | ||
Common stock, shares authorized | 500,000,000 | 273,986,920 |
Common stock par or stated value per share | $ 0.001 | $ 0.001 |
Common stock conversion basis | one | |
Cash dividends | $ 0 | |
Common Class B [Member] | ||
Class Of Stock [Line Items] | ||
Common stock, shares authorized | 14,600,000 | 21,593,607 |
Common stock par or stated value per share | $ 0.001 | $ 0.001 |
Cash dividends | $ 0 |
Stock Compensation - Additional
Stock Compensation - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended | ||
Oct. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Apr. 30, 2021 | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value | $ 200 | |||
Stock-based compensation expense | $ 3,012 | $ 331 | ||
Common Class A | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Number of options, Granted | 145,805 | 33,289 | ||
ESPP [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Purchase Price of Common Stock, Percent | 85.00% | |||
Share Based Compensation Arrangement By Share Based Payment Award Minimum Employee Subscription Rate | 1.00% | |||
Share-based Compensation Arrangement by Share-based Payment Award, Maximum Employee Subscription Rate | 15.00% | |||
Common Stock Capital Shares Minimum Increase In Shares Reserved For Future Issuance | 440,502 | |||
Percentage Of Shares Of Company Common Stock Outstanding For Increase In Shares Reserved For Issuance Under Stock Plan | 1.00% | |||
Share-based Compensation Arrangement by Share-based Payment Award, Shares Issued in Period | 0 | |||
Restricted Stock [Member] | Common Class A | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share based Compensation Arrangement By Share based Payment Award Restricted Shares Of Fully Issued And Outstanding Common Stock | 49,636 | |||
Employee Stock Purchase Plan ESPP [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Common Stock, Capital Shares Reserved for Future Issuance | 220,251 | |||
2021 Equity Incentive Plan [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Common Stock, Capital Shares Reserved for Future Issuance | 2,213,773 | |||
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | 1,403,096 | |||
2017 and 2021 Amended Equity Incentive Plan [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $ 9.36 | $ 2.24 | ||
2017 and 2021 Amended Equity Incentive Plan [Member] | Unvested Stock Options And Restricted Stock Awards [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount | $ 11,800 | |||
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition | 2 years 11 months 1 day | |||
2017 and 2021 Amended Equity Incentive Plan [Member] | Restricted Stock [Member] | ||||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||||
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period | 1 year | |||
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value | $ 6.37 | |||
Stock-based compensation expense | $ 300 |
Stock Compensation - Summary of
Stock Compensation - Summary of Share-based Compensation Arrangements by Share-based Payment Award (Details) - 2017 EIP And 2021 EIP [Member] - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Number of Options, Beginning | 1,855,507 | |
Number of options, Granted | 1,217,914 | |
Number of Options, Exercised | (145,805) | |
Number of Options, Cancelled and forfeited | (3,095) | |
Number of Options, Ending | 2,924,521 | 1,855,507 |
Number of Options, Options exercisable | 467,621 | |
Number of Options, Vested and expected to vest | 2,924,521 | |
Weighted average exercise price Opening balance | $ 2.99 | |
Weighted average exercise price, Granted | 9.36 | |
Weighted average exercise price, Exercised | 3.77 | |
Weighted average exercise price, Cancelled and forfeited | 9.39 | |
Weighted average exercise price Ending balance | 5.62 | $ 2.99 |
Weighted average exercise price, Options exercisable | 3.01 | |
Weighted average exercise price, Vested and expected to vest | $ 5.62 | |
Weighted average remaining contractual term | 9 years 1 month 9 days | 9 years 9 months 14 days |
Weighted average remaining contractual term, Options exercisable | 8 years 10 months 28 days | |
Weighted average remaining contractual term, Vested and expected to vest | 9 years 1 month 9 days | |
Intrinsic Value | $ 61,712 | $ 8 |
Intrinsic Value, Options exercisable | 11,089 | |
Intrinsic Value, Vested and expected to vest | $ 61,712 |
Stock Compensation - Summary _2
Stock Compensation - Summary of Share-based Payment Arrangement, Expensed and Capitalized, Amount (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Share-based Payment Arrangement, Expense | $ 3,012 | $ 331 |
Employees [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Share-based Payment Arrangement, Expense | 2,605 | 321 |
Nonemployees [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Share-based Payment Arrangement, Expense | 407 | 10 |
Research and Development [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Share-based Payment Arrangement, Expense | 915 | 4 |
General and Administrative [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Share-based Payment Arrangement, Expense | $ 2,097 | $ 327 |
Stock Compensation - Schedule o
Stock Compensation - Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions (Details) | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Expected volatility, Minimum | 75.40% | 86.10% |
Expected volatility, Maximum | 76.80% | 92.50% |
Risk-free rate, Minimum | 0.60% | 0.41% |
Risk-free rate, Maximum | 1.30% | 1.67% |
Minimum [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Expected term (in years) | 5 years 6 months | 5 years 6 months |
Maximum [Member] | ||
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | ||
Expected term (in years) | 6 years 1 month 6 days | 6 years 1 month 6 days |
Stock Compensation - Summary _3
Stock Compensation - Summary of Share-based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity (Details) - Restricted Stock [Member] | 12 Months Ended |
Dec. 31, 2021shares | |
Schedule Of Share Based Payment Award Stock Options Valuation Assumptions [Line Items] | |
Unvested as of December 31, 2020 | 41,363 |
Vested | (41,363) |
Unvested as of December 31, 2021 | 0 |
Employee Benefit Plans - Additi
Employee Benefit Plans - Additional Information (Details) | 12 Months Ended |
Dec. 31, 2021USD ($) | |
Compensation And Retirement Disclosure [Abstract] | |
Employer contributions | $ 0 |
License and Collaborations - Ad
License and Collaborations - Additional Information (Detail) - USD ($) | Oct. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 |
License And Collaborations [Line Items] | ||||
Stock shares issued during the period value | $ 48,411,000 | |||
Research and development | $ 22,484,000 | $ 45,206,000 | ||
Series C [Member] | ||||
License And Collaborations [Line Items] | ||||
Temporary equity purchase price per share | $ 0.5918 | |||
Ares Agreement | Ares Trading S A | ||||
License And Collaborations [Line Items] | ||||
Milestone payments paid | 25,000,000 | |||
Payment for royalties on a licensed product, Term | 2 years | |||
Related party transaction, expenses from transactions with related party | $ 1,700,000 | |||
Ares Agreement | Ares Trading S A | Series C [Member] | ||||
License And Collaborations [Line Items] | ||||
Initial fee paid as consideration | 22,171,553 | |||
Temporary equity purchase price per share | $ 0.5918 | |||
Temporary equity shares issued during the period value | $ 13,100,000 | |||
Ares Agreement | Ares Trading S A | Achievement Of Specified BLA Filing Or Regulatory Approval Milestones [Member] | ||||
License And Collaborations [Line Items] | ||||
Milestone payments payable | 176,500,000 | |||
Ares Agreement | Ares Trading S A | Achievement Of Specified Commercial Milestones [Member] | ||||
License And Collaborations [Line Items] | ||||
Milestone payments payable | $ 515,000,000 | |||
Ares Agreement | Ares Trading S A | Research and Development [Member] | ||||
License And Collaborations [Line Items] | ||||
Non-refundable license issue fee | 13,100,000 | |||
Milestone payments recorded to research and development expense | $ 25,000,000 | |||
Amplyx Agreement | ||||
License And Collaborations [Line Items] | ||||
Milestone payments payable | 2,000,000 | |||
Acquisition cost | 5,000 | |||
Research and development | 7,000,000 | |||
Amplyx Agreement | Amplyx and Novartis | Achievement of Various Clinical Development and Regulatory Milestones [Member] | ||||
License And Collaborations [Line Items] | ||||
Milestone payments payable | 76,000,000 | |||
Amplyx Agreement | Amplyx and Novartis | Achievement as Assumed Liabilities upon Acquisition [Member] | ||||
License And Collaborations [Line Items] | ||||
Milestone payments payable | $ 2,000,000 |
Income Taxes - Schedule of Inco
Income Taxes - Schedule of Income (loss) Before Provision for Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Income Tax Disclosure [Abstract] | ||
Domestic | $ (32,608) | $ (53,412) |
Foreign | 0 | 0 |
Income/(loss) before income taxes | $ (32,608) | $ (53,412) |
Income Taxes - Schedule of Comp
Income Taxes - Schedule of Components of Provision for Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Current: | ||
Federal | $ 0 | $ 0 |
State | 1 | 1 |
Total current | 1 | 1 |
Deferred: | ||
Total deferred | 0 | 0 |
Provision for income taxes | $ 1 | $ 1 |
Income Taxes - Schedule of Reco
Income Taxes - Schedule of Reconciliation of Provision for Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Valuation Allowance [Line Items] | ||
Tax on U.S. statutory rate on income before income taxes | $ (6,847) | $ (11,217) |
State Taxes | (5,405) | 1 |
Tax credits | 122 | |
Other | 248 | 109 |
Provision for income taxes | 1 | 1 |
Federal | ||
Valuation Allowance [Line Items] | ||
Valuation allowance | 6,600 | 10,986 |
State | ||
Valuation Allowance [Line Items] | ||
Valuation allowance | $ 5,405 |
Income Taxes - Summary of Defer
Income Taxes - Summary of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 |
Deferred Tax Assets, Net [Abstract] | ||
Federal and state NOL carryforward | $ 17,469 | $ 9,681 |
Research and other credits | 2,671 | 2,652 |
Fixed assets | 15 | 25 |
Reserves and accruals | 947 | 554 |
Stock based compensation | 535 | 119 |
Other intangibles | 12,589 | 8,019 |
Other DTA | 266 | |
Total gross DTA | 34,492 | 21,050 |
Less: valuation allowance | (34,492) | (21,050) |
Total deferred tax assets | 0 | 0 |
Deferred tax liabilities | 0 | 0 |
Net deferred tax assets | $ 0 | $ 0 |
Income Taxes - Summary of Activ
Income Taxes - Summary of Activity Relating to Gross Amount of Unrecognized Tax Benefits (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Income Tax Uncertainties [Abstract] | ||
Beginning balance | $ 663 | $ 651 |
Additions based on tax positions related to prior year | 19 | |
Decreases based on tax positions related to prior year | (97) | (120) |
Additions based on tax positions related to current year | 102 | 113 |
Ending balance | $ 668 | $ 663 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Details) - USD ($) | 12 Months Ended | ||
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019 | |
Operating Loss Carryforwards [Line Items] | |||
Valuation allowance | $ 34,492,000 | $ 21,050,000 | |
Federal net operating loss carryforwards | 57,600,000 | ||
Unrecognized Tax Benefits | 668,000 | 663,000 | $ 651,000 |
Income Tax Examination, Penalties and Interest Expense | 0 | 0 | |
Interest or penalty accruals associated with uncertain tax benefits | 0 | $ 0 | |
Federal | |||
Operating Loss Carryforwards [Line Items] | |||
Operating loss carryforwards | $ 67,800,000 | ||
Operating loss carryforwards expiration year | 2032 | ||
Federal | 2032 | |||
Operating Loss Carryforwards [Line Items] | |||
Operating loss carryforwards | $ 100,000 | ||
Federal | Research | |||
Operating Loss Carryforwards [Line Items] | |||
Tax credit carryforward amount | 2,400,000 | ||
State | |||
Operating Loss Carryforwards [Line Items] | |||
Operating loss carryforwards | $ 35,700,000 | ||
Operating loss carryforwards expiration year | 2036 | ||
State | 2036 | |||
Operating Loss Carryforwards [Line Items] | |||
Operating loss carryforwards | $ 300,000 | ||
State | Research | |||
Operating Loss Carryforwards [Line Items] | |||
Tax credit carryforward amount | $ 900,000 |
Commitments and Contingencies -
Commitments and Contingencies - Summary of Future Minimum Lease Payments For Operating Leases (Details) $ in Thousands | Dec. 31, 2021USD ($) | |
Commitments And Contingencies Disclosure [Abstract] | ||
Operating Leases, 2021 (remaining 3 months) | $ 2,669 | [1] |
Operating Leases 2022 | 2,755 | [1] |
Operating Leases 2023 | 2,818 | [1] |
Operating Leases 2024 | 1,954 | [1] |
Operating Leases 2025 | 10,196 | [1] |
Sublease Income, 2021 (remaining 6 months) | (1,901) | |
Sublease Income, 2022 | (1,964) | |
Sublease Income, 2023 | (2,029) | |
Sublease Income, 2024 | (1,569) | |
Sublease Income, 2025 | $ (7,463) | |
[1] | Future minimum lease payments include repayment of outstanding restructuring liabilities. |
Commitments and Contingencies_2
Commitments and Contingencies - Additional Information (Details) - PNAI [Member] $ in Thousands | Nov. 30, 2021USD ($)ft² | Dec. 31, 2021USD ($) | Dec. 31, 2020USD ($) | Nov. 30, 2020USD ($) | Aug. 30, 2018ft² | Apr. 30, 2018USD ($) | Jan. 31, 2018 | Apr. 30, 2015ft² |
Other Commitments [Line Items] | ||||||||
Operating lease minimum future commitments | $ 9,300 | |||||||
Operating lease, rent expense | $ 24,000 | $ 2,100 | ||||||
Research And Laboratory Equipment [Member] | ||||||||
Other Commitments [Line Items] | ||||||||
Operating lease, rent expense | 0 | $ 300 | ||||||
Office and Laboratory Space at Woborn Massauchets [Member] | ||||||||
Other Commitments [Line Items] | ||||||||
Area of real estate availed on lease | ft² | 4,900 | 24,606 | 3,800 | |||||
Operating lease term | 36 months | 84 months | 39 months | |||||
Letters of credit outstanding | $ 300 | |||||||
Operating lease renewal term | 3 years | |||||||
Operating lease minimum future commitments | $ 9,300 | $ 7,925 | ||||||
Percentage of increase in rent annually | 3.00% | |||||||
Base rent | $ 300 |
Restructuring and Related Act_3
Restructuring and Related Activities - Additional Information (Detail) - USD ($) $ in Thousands | Dec. 31, 2021 | Dec. 31, 2020 | Nov. 30, 2020 |
Restructuring Cost And Reserve [Line Items] | |||
Restructuring liability | $ 1,634 | $ 2,596 | |
Employee Severance And Other Employee Termination [Member] | |||
Restructuring Cost And Reserve [Line Items] | |||
Restructuring liability | $ 300 | ||
Leased Facilities Abandoned [Member] | Discounted Lease Related Restructuring Liability [Member] | |||
Restructuring Cost And Reserve [Line Items] | |||
Restructuring liability | 2,200 | ||
Equipment Abandoned [Member] | Discounted Lease Related Restructuring Liability [Member] | |||
Restructuring Cost And Reserve [Line Items] | |||
Restructuring liability | $ 800 |
Restructuring and Related Act_4
Restructuring and Related Activities - Summary of Activity Related to the Restructuring Liabilities (Detail) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Restructuring Cost And Reserve [Line Items] | ||
Beginning balance | $ 2,596 | |
Accretion | 145 | |
Provision | 28 | |
Cash payments | (999) | $ (2,423) |
Lease assignment to NeuBase | 136 | |
Ending balance | 1,634 | 2,596 |
Lease Related Exit Cost | ||
Restructuring Cost And Reserve [Line Items] | ||
Beginning balance | 2,584 | |
Accretion | 145 | |
Provision | 28 | |
Cash payments | (987) | |
Lease assignment to NeuBase | 136 | |
Ending balance | 1,634 | 2,584 |
Employee Severance | ||
Restructuring Cost And Reserve [Line Items] | ||
Beginning balance | 12 | |
Cash payments | $ (12) | |
Ending balance | $ 12 |
Net Loss Per Common Share - Sum
Net Loss Per Common Share - Summary of Dilutive Shares Excluded from Computation of Diluted Net Loss Per Share (Detail) - shares | 12 Months Ended | |
Dec. 31, 2021 | Dec. 31, 2020 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Redeemable convertible preferred stock | 2,924,521 | 17,670,884 |
Redeemable Convertible Preferred Stock [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Redeemable convertible preferred stock | 15,774,014 | |
Class A Common Stock Options Issued and Outstanding | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Redeemable convertible preferred stock | 2,924,521 | 1,855,507 |
Unvested Restricted Stock Awards | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Redeemable convertible preferred stock | 41,363 |
Related Party Transactions - Ad
Related Party Transactions - Additional Information (Details) - Lessee Company Where Ceo of the Lessor Company is the Member of Board of Directors [Member] $ in Millions | Dec. 07, 2018ft² | Dec. 31, 2021 | Dec. 31, 2020USD ($) | Apr. 01, 2019ft² |
Defined Benefit Plan Disclosure [Line Items] | ||||
Area of space subleased | 400 | |||
Revised area of space subleased | 3,700 | |||
Sublease lease term extension | 2 years | |||
Percentage of profit arising on sublease on account of excess amount collected from subtenant to be shared | 50.00% | |||
Operating lease rental expense sublease rentals | $ | $ 0.2 |
Subsequent Event - Additional I
Subsequent Event - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | Feb. 14, 2022 | Feb. 09, 2022 | May 20, 2021 | Dec. 31, 2021 |
Subsequent Event [Line Items] | ||||
Payments of offering costs | $ 2,765 | |||
Common Class A | ||||
Subsequent Event [Line Items] | ||||
Stock Issued During Period Shares New Issues | 5,002,500 | |||
Payments of offering costs | $ 300 | |||
Common Class A | Over-Allotment Option | ||||
Subsequent Event [Line Items] | ||||
Stock Issued During Period Shares New Issues | 652,500 | |||
Subsequent Event | ||||
Subsequent Event [Line Items] | ||||
Sale Of Stock Consideration Received On Transaction | $ 80,200 | |||
Underwriting Discounts and Commissions | 5,200 | |||
Payments of offering costs | $ 800 | |||
Subsequent Event | Common Class A | ||||
Subsequent Event [Line Items] | ||||
Sale of Stock, Number of Shares Issued in Transaction | 5,742,026 | |||
Sale Of Stock Price Per Share | $ 15 | |||
Subsequent Event | Common Class A | Over-Allotment Option | ||||
Subsequent Event [Line Items] | ||||
Stock Issued During Period Shares New Issues | 748,959 |