CONFIDENTIAL
The first is an addiction-specific form of cognitive behavioral therapy, or CBT, that moves patients from actively using a substance to reducing and ultimately discontinuing use. The second mechanism of action is fluency training. This approach assesses proficiency and reinforces concept mastery. Third is contingency management, which is a positive reinforcement mechanism.
Throughout treatment, these distinct components work in concert. CBT and fluency training strengthen affected neuro-circuitry, while contingency management induces dopamine in the nucleus accumbens repairing dysfunctional neurophysiology and driving engagement with CBT and treatment in a virtuous cycle.
As the patient progresses through treatment, product use information is shared with the clinical care team via the clinician dashboard facilitating the care team to inform optimal patient care. reSET and reSET-O provide 24/7 anytime, anywhere treatment that is FDA-authorized to improve outcomes.
Slide 24
reSET and reSET-O show strong randomized clinical trial data and equally impressive real-world outcomes. In randomized, controlled clinical trials, reSET doubled rates of abstinence, and 82% of patients were retained in therapy for reSET-O. Studies have demonstrated the products were able to substitute for clinician time, have durable use for 12 months, and economic evaluation of real-world claims found a reduction of 62% in inpatient hospitalization and a 20% reduction in ER visits during the 6 months following treatment initiation, and benefit will grow as we measure longer periods.
These products facilitate patients who seek to break the negative cycle of craving, use, and despair. If patients are successful in their recovery journey, it would enable them to re-enter society, restore relationships, and gain employment. Pear is only just getting started, and we believe the impact of our products to grow as we measure longer periods of time and work to achieve a consistent, superior performance across RCTs, RWE, and HEOR.
Now, I would like to turn it over to my colleague, Julia Strandberg, Pear’s Chief Commercial Officer.
Julia
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Thank you, Yuri. We are proud of how Pear’s self-commercialization efforts are taking shape . . . and building momentum. We have seen patient demand, with over 20,000 prescriptions since launch.
With patients at the forefront of what we do, we have been encouraged by a net promotor score of 68, which is similar to leading consumer companies and five times that of most drug companies. This is particularly reassuring when considered alongside our 88% patient satisfaction rate.
On the provider side, more than 700 clinicians across 32 states have prescribed reSET or reSET-O to date. Some of these early adopters are large addiction health systems like Wellpath, hospital network providers like Northwell and Kaiser, and academic medical centers like MGH. Overall, 82% of providers have expressed satisfaction with Pear’s products. We believe that is due to three primary factors: quality of the products; the three-way engagement among patient, clinician, and product; and the additional support from our patient service center, Pear Connect.