EXPLANATORY NOTE
This Registration Statement on Form S-8 (this “Registration Statement”) is being filed by Ambrx Biopharma Inc. (the “Registrant”) for the purpose of registering (i) an additional 13,522,762 ordinary shares (an equivalent of 1,931,823 American Depositary Shares) under the Ambrx Biopharma Inc. 2021 Equity Incentive Plan (the “2021 Plan”), pursuant to the provisions of the 2021 Plan which provide for annual automatic increases in the number of ordinary shares reserved for issuance under the 2021 Plan, and (ii) an additional 2,704,552 ordinary shares (an equivalent of 386,364 American Depositary Shares) under the Ambrx Biopharma Inc. 2021 Employee Share Purchase Program (the “2021 ESPP”), pursuant to the provisions of the 2021 ESPP which provide for annual automatic increases in the number of ordinary shares reserved for issuance under the 2021 ESPP. These additional ordinary shares are securities of the same class as other securities for which Registration Statements of the Registrant on Form S-8 relating to the same employee benefit plans are effective.
PART II
INFORMATION REQUIRED IN THE REGISTRATION STATEMENT
Item 3. Incorporation of Documents By Reference.
The Registrant previously registered ordinary shares for issuance under the 2021 Plan and the 2021 ESPP pursuant to (i) a Registration Statement on Form S-8 (File No. 333-257264) filed with the Securities and Exchange Commission (the “Commission”) on June 22, 2021, and (ii) a Registration Statement on Form S-8 (File No. 333-264490) filed with the Commission on April 26, 2022 (collectively, the “Prior Registration Statements”). In accordance with General Instruction E to Form S-8, the contents of the Prior Registration Statements are hereby incorporated by reference.
The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed by the Registrant with the Commission:
(a) the Registrant’s Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the Commission on March 30, 2023;
(b) the Registrant’s Current Reports on Form 8-K (other than information furnished rather than filed) filed with the Commission on January 30, 2023, February 6, 2023, February 17, 2023, February 24, 2023, March 1, 2023, March 6, 2023 and March 13, 2023; and
(c) the description of the Registrant’s ordinary shares in the registration statement on Form 8-A filed with the Commission on June 15, 2021, as amended on March 16, 2023, including any amendments or reports filed for the purpose of updating such description.
All documents subsequently filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent to the date of this Registration Statement and prior to the filing of a post-effective amendment to this Registration Statement which indicates that all securities offered hereby have been sold or which deregisters all such securities then remaining unsold, shall be deemed to be incorporated by reference herein and to be a part hereof from the date of filing of such documents.
Any statement contained in this Registration Statement, in an amendment hereto or in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a statement contained herein or in any subsequently filed amendment to this Registration Statement or in any document that also is or is deemed to be incorporated by reference herein modifies or supersedes such statement. Any statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement, except as to specific section of such statements as set forth therein.