SOPHiA GENETICS (SOPH) 20-F 7 Mar 23 2022 FY Annual report (foreign) Financial data

Cover Page

Cover Page	12 Months Ended
	Dec. 31, 2022 shares
Document Information [Line Items]
Document Type	20-F
Document Registration Statement	false
Document Annual Report	true
Document Period End Date	Dec. 31, 2022
Current Fiscal Year End Date	--12-31
Document Transition Report	false
Document Shell Company Report	false
Entity File Number	001-40627
Entity Registrant Name	SOPHiA GENETICS SA
Entity Incorporation, State or Country Code	V8
Entity Address, Address Line One	Rue du Centre 172
Entity Address, Postal Zip Code	CH-1025
Entity Address, City or Town	Saint-Sulpice
Entity Address, Country	CH
Title of 12(b) Security	Ordinary shares, par value CHF 0.05 per share
Trading Symbol	SOPH
Security Exchange Name	NASDAQ
Entity Common Stock, Shares Outstanding (in shares)	64,231,220
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Accelerated Filer
Entity Emerging Growth Company	true
Entity Ex Transition Period	false
ICFR Auditor Attestation Flag	false
Document Accounting Standard	International Financial Reporting Standards
Entity Shell Company	false
Entity Central Index Key	0001840706
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	FY
Amendment Flag	false
Business Contact
Document Information [Line Items]
Entity Address, Address Line One	185 Dartmouth Street Floor 5
Entity Address, Postal Zip Code	MA 02116
Entity Address, City or Town	Boston
Contact Personnel Name	Ross Muken
City Area Code	617
Local Phone Number	982-1210

Audit Information

Audit Information	12 Months Ended
	Dec. 31, 2022
Auditor [Abstract]
Auditor Firm ID	1358
Auditor Name	PricewaterhouseCoopers SA
Auditor Location	Lausanne, Switzerland

Consolidated Statements of Loss

Consolidated Statements of Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Profit or loss [abstract]
Revenue	$ 47,560	$ 40,450	$ 28,400
Cost of revenue	(16,306)	(15,229)	(10,709)
Gross profit	31,254	25,221	17,691
Research and development costs	(35,371)	(26,578)	(18,588)
Selling and marketing costs	(28,267)	(28,735)	(17,432)
General and administrative costs	(55,816)	(41,505)	(18,965)
Other operating income (expense), net	377	108	(93)
Operating loss	(87,823)	(71,489)	(37,387)
Finance income (expense), net	238	(2,018)	(3,838)
Loss before income taxes	(87,585)	(73,507)	(41,225)
Income tax benefit (expense)	136	(168)	1,886
Loss for the year	(87,449)	(73,675)	(39,339)
Attributable to the owners of the parent	$ (87,449)	$ (73,675)	$ (39,339)
Earnings per share [abstract]
Basic loss per share (in dollars per share)	$ (1.36)	$ (1.33)	$ (0.93)
Diluted loss per share (in dollars per share)	$ (1.36)	$ (1.33)	$ (0.93)

Consolidated Statements of Comp

Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Statement of comprehensive income [abstract]
Loss for the year	$ (87,449)	$ (73,675)	$ (39,339)
Items that may be reclassified to statement of loss (net of tax)
Currency translation differences	(4,336)	(4,736)	7,338
Total items that may be reclassified to statement of loss	(4,336)	(4,736)	7,338
Items that will not be reclassified to statement of loss (net of tax)
Remeasurement of defined benefit plans	2,154	461	184
Total items that will not be reclassified to statement of loss	2,154	461	184
Other comprehensive (loss) income for the year	(2,182)	(4,275)	7,522
Total comprehensive loss for the year	(89,631)	(77,950)	(31,817)
Attributable to owners of the parent	$ (89,631)	$ (77,950)	$ (31,817)

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets
Cash and cash equivalents	$ 161,305	$ 192,962
Term deposits	17,307	72,357
Accounts receivable	6,649	6,278
Inventory	5,156	5,729
Prepaids and other current assets	5,838	5,529
Total current assets	196,255	282,855
Non-current assets
Property and equipment	7,129	4,663
Intangible assets	19,963	15,673
Right-of-use assets	14,268	11,292
Deferred tax assets	1,940	1,990
Other non-current assets	4,283	3,700
Total non-current assets	47,583	37,318
Total assets	243,838	320,173
Current liabilities
Accounts payable	6,181	6,737
Accrued expenses	14,505	15,972
Deferred contract revenue	3,434	4,069
Current portion of lease liabilities	2,690	1,813
Other current liabilities	0	12
Total current liabilities	26,810	28,603
Non-current liabilities
Lease liabilities, net of current portion	14,053	11,246
Defined benefit pension liabilities	2,675	4,453
Other non-current liabilities	170	471
Total non-current liabilities	16,898	16,170
Total liabilities	43,708	44,773
Equity
Share capital	3,464	3,328
Share premium	471,623	470,887
Treasury shares	(117)	0
Other reserves	23,963	12,539
Accumulated deficit	(298,803)	(211,354)
Total equity	200,130	275,400
Total liabilities and equity	$ 243,838	$ 320,173

Consolidated Statement of Chang

Consolidated Statement of Changes in Equity $ in Thousands	USD ($) shares	Initial Public Offering USD ($)	Private Placement USD ($)	Greenshoe Offering USD ($)	Share capital USD ($) shares	Share capital Initial Public Offering USD ($) shares	Share capital Private Placement USD ($) shares	Share capital Greenshoe Offering USD ($) shares	Treasury Share capital USD ($) shares	Share premium USD ($)	Share premium Initial Public Offering USD ($)	Share premium Private Placement USD ($)	Share premium Greenshoe Offering USD ($)	Other reserves USD ($)	Accumulated deficit USD ($)
Balance at beginning of period (in shares) at Dec. 31, 2019 | shares					38,319,760				0
Balance at beginning of period at Dec. 31, 2019	$ 22,253				$ 1,947				$ 0	$ 119,227				$ (581)	$ (98,340)
Loss for the period	(39,339)														(39,339)
Other comprehensive loss	7,522													7,522
Total comprehensive loss for the year	(31,817)													7,522	(39,339)
Share-based compensation	1,359													1,359
Transactions with owners
Share options exercised (in shares) | shares					319,000
Share options exercised	1,072				$ 17					1,055
Sale of ordinary shares, net of transaction costs (in shares) | shares					9,316,940
Sale of ordinary shares, net of transaction costs	107,643				$ 496					107,147
Balance at end of period (in shares) at Dec. 31, 2020 | shares					47,955,700				0
Balance at end of period at Dec. 31, 2020	100,510				$ 2,460				$ 0	227,429				8,300	(137,679)
Loss for the period	(73,675)														(73,675)
Other comprehensive loss	(4,275)													(4,275)
Total comprehensive loss for the year	(77,950)													(4,275)	(73,675)
Share-based compensation	8,514													8,514
Transactions with owners
Share options exercised (in shares) | shares					1,271,300
Share options exercised	$ 4,527				$ 69					4,458
Sale of ordinary shares, net of transaction costs (in shares) | shares						13,000,000	1,111,111	519,493
Sale of ordinary shares, net of transaction costs		$ 211,663	$ 19,648	$ 8,488		$ 710	$ 61	$ 28			$ 210,953	$ 19,587	$ 8,460
Balance at end of period (in shares) at Dec. 31, 2021 | shares	63,857,604				63,857,604				0
Balance at end of period at Dec. 31, 2021	$ 275,400				$ 3,328				$ 0	470,887				12,539	(211,354)
Loss for the period	(87,449)														(87,449)
Other comprehensive loss	(2,182)													(2,182)
Total comprehensive loss for the year	(89,631)													(2,182)	(87,449)
Share-based compensation	13,613													13,613
Transactions with owners
Share options exercised and vesting of Restricted Stock Units (in shares) | shares									373,616
Share options exercised and vesting of Restricted Stock Units	748								$ 19	736				(7)
Issuance of shares to be held as treasury shares (in shares) | shares					2,540,560				2,540,560
Issuance of shares to be held as treasury shares					$ 136				$ (136)
Balance at end of period (in shares) at Dec. 31, 2022 | shares					66,398,164				2,166,944
Balance at end of period at Dec. 31, 2022	$ 200,130				$ 3,464				$ (117)	$ 471,623				$ 23,963	$ (298,803)

Consolidated Statement of Cash

Consolidated Statement of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Operating activities
Loss before income tax	$ (87,585)	$ (73,507)	$ (41,225)
Adjustments for non-monetary items
Depreciation	3,791	2,517	1,758
Amortization	1,780	1,092	632
Interest expense	639	658	1,224
Interest income	(1,324)	(20)	(96)
Gain on TriplePoint success fee	0	(430)	0
Expected credit loss allowance	(467)	(988)	763
Share-based compensation	13,613	8,514	1,359
Intangible assets write-off	73	30	226
Movements in provisions, pensions, and government grants	953	(23)	1,203
Research tax credit	(1,292)	(1,597)	(763)
Loss on disposal of property and equipment	0	22	0
Working capital changes
(Increase) decrease in accounts receivable	1,332	1,806	1,118
(Increase) decrease in prepaids and other assets	(977)	(2,330)	2,347
(Increase) decrease in inventory	(200)	(2,336)	536
Increase (decrease) in accounts payables, accrued expenses, deferred contract revenue, and other liabilities	(1,428)	8,980	(185)
Cash used in operating activities
Income tax received (paid)	0	(55)	153
Interest paid	(266)	(286)	(855)
Interest received	1,265	14	75
Net cash flows used in operating activities	(70,093)	(57,939)	(31,730)
Investing activities
Purchase of property and equipment	(4,097)	(2,683)	(450)
Acquisition of intangible assets	(464)	(130)	(318)
Capitalized development costs	(5,820)	(3,858)	(2,436)
Proceeds upon maturity of term deposits and short-term investments	78,533	21,878	0
Purchase of term deposits and short-term investments	(26,179)	(72,141)	(21,119)
Net cash flow provided from (used in) investing activities	41,973	(56,934)	(24,323)
Financing activities
Proceeds from exercise of share options	748	4,527	1,072
Proceeds from issuance of share capital, net of transaction costs	0	0	107,643
Proceeds from initial public offering, net of transaction costs	0	211,663	0
Proceeds from greenshoe, net of transaction costs	0	8,488	0
Proceeds from private placement, net of transaction costs	0	19,648	0
Payment of TriplePoint success fee	0	(2,468)	0
Proceeds from borrowings	0	0	15,839
Repayments of borrowings	0	(3,167)	(16,529)
Payments of principal portion of lease liabilities	(2,316)	(918)	(980)
Net cash flow (used in) provided from financing activities	(1,568)	237,773	107,045
Increase (decrease) in cash and cash equivalents	(29,688)	122,900	50,992
Effect of exchange differences on cash balances	(1,969)	(4,563)	5,564
Cash and cash equivalents at beginning of the year	192,962	74,625	18,069
Cash and cash equivalents at end of the year	$ 161,305	$ 192,962	$ 74,625

Company information and operati

Company information and operations	12 Months Ended
	Dec. 31, 2022
Disclosure Of Company Information And Operations [Abstract]
Company information and operations	Company information and operations General information SOPHiA GENETICS SA and its consolidated subsidiaries (NASDAQ: SOPH) (“the Company”) is a cloud-native software company in the healthcare space, incorporated on March 18, 2011, and headquartered in Saint-Sulpice, Switzerland. The Company is dedicated to establishing the practice of data-driven medicine as the standard of care in healthcare and for life sciences research. The Company has built a cloud-native software platform capable of analyzing data and generating insights from complex multimodal datasets and different diagnostic modalities. This platform, commercialized as “SOPHiA DDM TM ,” standardizes, computes, and analyzes digital health data and is used in decentralized locations to break down data silos. As of December 31, 2022, the Company had the following wholly-owned subsidiaries: Name Country of domicile SOPHiA GENETICS S.A.S. France SOPHiA GENETICS LTD UK SOPHiA GENETICS, Inc. USA SOPHiA GENETICS Intermediação de Negócios LTDA Brazil SOPHiA GENETICS PTY LTD Australia SOPHiA GENETICS S.R.L. Italy Interactive Biosoftware S.A.S., a wholly owned subsidiary located in France and acquired in 2018, was merged into SOPHiA GENETICS S.A.S. in 2020. On April 9, 2021, SOPHiA GENETICS PTY LTD, a wholly owned subsidiary located in Australia, was incorporated. On May 27, 2021, SOPHiA GENETICS S.R.L., a wholly owned subsidiary located in Italy, was incorporated. On December 12, 2022, the Company changed the name of SOPHiA GENETICS Intermediação de Negócios EIRELI to SOPHiA GENETICS Intermediação de Negócios LTDA. The Company’s Board of Directors approved the issue of the consolidated financial statements on March 7, 2023. Share split On June 30, 2021, the Company effected a one-to-twenty share split of its outstanding shares. Accordingly, all share and per share amounts for all periods presented in these consolidated financial statements and notes thereto have been adjusted retroactively, where applicable, to reflect this share split. Initial public offering In July 2021, the Company completed its initial public offering (“IPO”) in the United States on the Nasdaq Global Market (“Nasdaq”) under the trading ticker symbol “SOPH”. Trading on the Nasdaq commenced at market open on July 23, 2021. The Company completed the IPO of 13,000,000 ordinary shares, at an IPO price of $18.00 per share, par value $0.05 (CHF 0.05). The aggregate net proceeds received from the IPO, net of underwriting discounts and commissions and offering expenses, was $211.7 million. Immediately prior to the completion of the IPO, all then outstanding shares of preferred shares were converted into 24,561,200 shares of ordinary shares on a one-to-one basis. Concurrent with the IPO, the Company closed a private placement, in which it sold 1,111,111 ordinary shares to an affiliate of GE Healthcare at a price of $18.00 per share, par value $0.05 (CHF 0.05). The aggregate net proceeds received from the private placement, net of offering expenses, was $19.6 million. On August 25, 2021, the underwriters of the IPO elected to exercise in part their option to purchase an additional 519,493 ordinary shares (“greenshoe”) at the IPO price of $18.00 per share, par value $0.05 (CHF 0.05). The aggregate net proceeds received from the greenshoe, net of underwriting discounts and commissions and offering expenses, was $8.5 million. Issued share capital As of December 31, 2022, the Company had issued 66,398,164 shares of which 64,231,220 are outstanding and 2,166,944 are held by the Company as treasury shares. As of December 31, 2021, the Company had issued outstanding shares of 63,857,604. All shares were considered paid as of December 31, 2022 Treasury shares During the first quarter of 2022, the Company issued 2,540,560 common share options to SOPHiA GENETICS LTD pursuant to a share delivery and repurchase agreement, which were immediately exercised, and repurchased the shares to hold as treasury shares for the purposes of administering the Company's equity incentive programs. As of December 31, 2022, the Company held 2,166,944 treasury shares. The Company held no treasury shares in 2021. Treasury shares are recognized at acquisition cost and recorded as treasury shares at the time of the transaction. Upon exercise of share options or vesting of restricted stock units, the treasury shares are subsequently transferred. Any consideration received is included in shareholders’ equity.

Significant accounting policies

Significant accounting policies	12 Months Ended
	Dec. 31, 2022
Summary Of Significant Accounting Policies [Abstract]
Significant accounting policies	Significant accounting policies Basis of preparation Compliance with International Financial Reporting Standards The consolidated financial statements of the Company have been prepared in accordance with International Financial Reporting Standards (“IFRS”) and interpretations issued by the IFRS Interpretations Committee (“IFRS IC”) applicable to companies reporting under IFRS. The consolidated financial statements comply with IFRS as issued by the International Accounting Standards Board (“IASB”). Basis of consolidation A subsidiary is an entity over which the Company has control. The Company controls an entity when it has the power to direct its activities and has rights to its variable returns. Subsidiaries are fully consolidated from the date on which control is transferred to the Company and deconsolidated from the date that control ceases. During the consolidation process intercompany transactions, balances, and unrealized gains on transactions between companies are eliminated. Unrealized losses are also eliminated unless there is evidence of an impairment of the transferred asset. In order to ensure consistency with the accounting policies of the Company, the accounting policies of subsidiaries have been changed where necessary. Foreign currency translation Items included in the consolidated financial statements of each of the Company’s entities are measured using the currency of the primary economic environment in which the entity operates (“functional currency”). In individual entities, transactions in foreign currencies are translated as of transaction date. Monetary assets and liabilities in foreign currencies are translated at month end rates. The Company’s reporting currency of the Company’s consolidated financial statements is the U.S. dollar (“USD”). Assets and liabilities denominated in foreign currencies are translated at the month-end spot exchange rates, income statement accounts are translated at average rates of exchange for the period presented, and equity is translated at historical exchange rates. On consolidation, assets and liabilities of foreign operations reported in their local functional currencies are translated into USD. Differences arising from the retranslation of opening net assets of foreign operations, together with differences arising from the translation of the net results for the year of foreign operations, are recognized in other comprehensive income under currency retranslations. Gains or losses resulting from foreign currency transactions are included in net income. The Company selected the U.S. dollar as its presentation currency for purposes of its consolidated financial statements instead of the Company’s functional currency, the Swiss franc, because of the global nature of its business, its expectation that an increasing portion of revenues and expenses will be denominated in USD, and its plans to continue to access U.S. capital markets. Use of estimates The preparation of consolidated financial statements in conformity with IFRS requires the use of accounting estimates. It also requires management to exercise judgement in applying the Company’s accounting policies. The Company’s significant estimates and judgements included in the preparation of the consolidated financial statements are related to revenue recognition, capitalized internal software development costs, share-based compensation, expected credit loss, goodwill, defined benefit pension liabilities, uncertain tax positions, and derivatives. Disclosed in the corresponding sections within the footnotes are the areas which require a high degree of judgment, significant assumptions, and/or estimates. Going concern basis The consolidated financial statements have been prepared on a going concern basis (See Note 31 – “Capital management”). Historical cost convention The consolidated financial statements have been prepared on a historical cost basis except for certain assets and liabilities, which are carried at fair value. Accounting policies The significant accounting policies adopted in the preparation of the consolidated financial statements have been consistently applied, unless otherwise stated. Provisions and contingencies Provisions comprise liabilities of uncertain timing or amount. The provisions and liabilities are recognized when the Company has a present legal or constructive obligation as a result of past events, it is probable that an outflow of resources will be required to settle the obligation, and the amount can be reliably estimated. Provisions are not recognized for future operating losses. Provisions are measured at the present value of management’s best estimate of the expenditure required to settle the present obligation at the end of the reporting period, unless the impact of discounting is immaterial. The discount rate used to determine the present value is a pre-tax rate that reflects current market assessments of the time value of money and the risks specific to the liability. The increase in the provision due to the passage of time is recognized as interest expense. Contingent liabilities are possible obligations that arise from past events and whose existence will be confirmed only by the occurrence or non-occurrence of one or more uncertain future events not fully within the control of the Company. The likelihood of occurrence of provisions and contingent liabilities requires use of judgement. Judgement is also required to determine if an outflow of economic resources is probable, or possible but not probable. Where it is probable, a liability is recognized, and further judgement is used to determine the level of the provision. Where it is possible but not probable, further judgement is used to determine if the likelihood is remote, in which case no disclosures are provided; if the likelihood is not remote then judgement is used to determine the contingent liability disclosed. Financial assets classification Upon recognition, financial assets are classified on the basis of how the financial assets are measured: at amortized cost or fair value through income. The classification of financial assets at initial recognition depends on the financial asset’s contractual cash flow characteristics and the Company’s business model for managing them. Except for accounts receivable that do not contain a significant financing component, the Company initially measures a financial asset at its fair value plus, in the case of a financial asset not at fair value through income, transaction costs. Accounts receivable that do not contain a significant financing component are measured at the transaction price. The Company’s business model for managing financial assets is defined by whether cash flows will result from collecting contractual cash flows, selling the financial assets, or both. Financial assets held in order to collect contractual cash flows are measured at amortized cost. Financial assets held both to collect contractual cash flows and for sale are measured at fair value through other comprehensive income/loss. Purchases or sales of financial assets that require delivery of assets within a time frame established by regulation or convention in the marketplace (regular way trades) are recognized on the trade date, i.e., the date that the Company commits to purchase or sell the asset. Financial assets measured at amortized cost Financial assets initially measured at amortized cost are subsequently measured using the effective interest rate (“EIR”) method and are subject to impairment. Gains and losses are recognized in income when the asset is derecognized, modified, or impaired. The Company’s financial assets at amortized cost include cash, term deposits and accounts receivable. Financial assets—derecognition A financial asset (or, where applicable, a part of a financial asset or part of a group of similar financial assets) is primarily derecognized (i.e., removed from the Company’s consolidated balance sheet) when: • the rights to receive cash flows from the asset have expired or; • the Company has transferred its rights to receive cash flows from the asset or has assumed an obligation to pay the received cash flows in full without material delay to a third party under a ‘pass-through’ arrangement; and either; • the Company has transferred substantially all the risks and rewards of the asset, or; • the Company has neither transferred nor retained substantially all the risks and rewards of the asset but has transferred control of the asset. When the Company has transferred its rights to receive cash flows from an asset or has entered into a pass-through arrangement, it evaluates if, and to what extent, it has retained the risks and rewards of ownership. When the Company has neither transferred nor retained substantially all of the risks and rewards of the asset, nor transferred control of the asset, the Company continues to recognize the transferred asset to the extent of its continuing involvement. In that case, the Company also recognizes an associated liability. The transferred asset and the associated liability are measured on a basis that reflects the rights and obligations that the Company has retained. Continuing involvement that takes the form of a guarantee over the transferred asset is measured at the lower of the original carrying amount of the asset and the maximum amount of consideration that the Company could be required to repay. Financial assets—impairment For cash, cash equivalents, and term deposits, the Company invests in assets where it has never incurred and does not expect to incur credit losses. For accounts receivable the Company recognizes a loss allowance based on lifetime estimated credit losses (“ECL”) at each reporting date. When estimating the ECL the Company takes into consideration: readily available relevant and supportable information (this includes quantitative and qualitative data), the Company’s historical experience and forward-looking information specific to the receivables and the economic environment. See Note 13 – “Accounts receivable” for further information about the Company’s accounting for trade receivables. Financial liabilities classification Financial liabilities are classified upon initial recognition as financial liabilities measured at fair value through income or at amortized cost. The Company’s financial liabilities include accounts payable and debt (including borrowings and lease liabilities), which are measured at amortized cost, and derivatives, which are measured at fair value through income. Interest-bearing borrowings are initially recognized at fair value less directly attributable costs and subsequently measured at amortized cost using the EIR method. Gains and losses are recognized in income when the liabilities are derecognized as well as through the EIR amortization process. Amortized cost is calculated by taking into account any discount or premium on acquisition and fees or costs that are an integral part of the EIR. The EIR amortization is included as finance costs in the statement of income/loss. Financial liabilities—derecognition A financial liability is derecognized when the obligation under the liability is discharged or canceled or expires. When an existing financial liability is replaced by another from the same lender on substantially different terms, or the terms of an existing liability are substantially modified, such an exchange or modification is treated as the derecognition of the original liability and the recognition of a new liability. The difference in the respective carrying amounts is recognized in the statements of loss. New standards, amendments to standards and interpretations New standards, amendments to standards, and interpretations issued recently effective As of January 1, 2022 the Annual Improvements to International Financial Reporting Standards (“IFRS”) Standards 2018–2020 (“Annual Improvements”) and the narrowed scope of the (“IFRS”) 3, Business Combinations (“IFRS 3”), IAS 16, Property, plant, and equipment (“IAS 16”), and IAS 37, Provisions, contingent liabilities, and contingent assets (“IAS 37”), as issued by the IASB became effective. The Company assessed the changes to the accounting standard and determined the improvements had no impact on the Company’s financial statements. New standards, amendments to standards, and interpretations issued not yet effective In January 2020, IASB issued amendments to paragraphs 69 to 76 of International Accounting Standard (“IAS”) 1, Presentation of Financial Statements (“IAS 1”), to specify the requirements for classifying liabilities as current or non-current, effective for annual reporting periods beginning on or after January 1, 2023. The Company determined the amendment has no impact. There are no other IFRS or IFRS IC interpretations that are not yet effective and that could have a material impact to the consolidated financial statements.

Segment reporting

Segment reporting	12 Months Ended
	Dec. 31, 2022
Disclosure of operating segments [abstract]
Segment reporting	Segment reporting The Company operates in a single operating segment. The Company’s financial information is reviewed, and its performance assessed as a single segment by the senior management team led by the Chief Executive Officer (“CEO”), the Company’s Chief Operating Decision Maker (“CODM”). For the years ended December 31, 2022 and 2021, respectively, the Company had a physical presence in three countries outside of its headquarters in Switzerland: France, the United States, and Brazil. An analysis of the location of non-current assets other than financial instruments and deferred tax assets by country is as follows (in USD thousands): Year ended December 31, 2022 2021 Switzerland $ 39,052 $ 28,973 France 498 290 United States 1,803 2,357 Brazil 6 8 Total non-current assets other than financial instruments and deferred tax assets $ 41,359 $ 31,628

Revenue

Revenue	12 Months Ended
	Dec. 31, 2022
Receivables from contracts with customers [abstract]
Revenue	Revenue Critical accounting estimates and judgements The Company recognizes revenue when control of promised goods or services is transferred to customers in an amount that reflects the consideration that is expected to be received for those goods or services. Significant judgment is required to determine the stand-alone selling price (“SSP”) for each performance obligation in the SOPHiA DDM Platform, the amount allocated to each performance obligation and whether it depicts the amount that the Company expects to receive in exchange for the related product and/or service. The Company enters into arrangements with multiple performance obligations where it could be difficult to determine the performance obligations under a sales agreement; in such cases, how and when revenue should be recognized is subject to certain estimates or assumptions. Should these judgments and estimates not be correct, revenue recognized for any reporting period could be adversely affected. Accounting policies Revenue represents amounts received and receivable from third parties for goods supplied and services rendered to customers. Revenues are reported net of rebates and discounts and net of sales and value added taxes in an amount that reflects the consideration that is expected to be received for goods or services. The majority of the sales revenue is recognized: (i) when customers generate analyses on their patient data through the SOPHiA DDM Platform, (ii) when consumables, namely DNA enrichment kits, are delivered to customers at which point control transfers, (iii) when services, namely set-up programs, are performed and (iv) over the duration of the software licensing arrangements for the Alamut software offerings. Products and services are sold both directly to customers and through distributors, generally under agreements with payment terms of up to 180 days. Therefore, contracts do not contain a significant financing component. For all contracts with customers the following steps are performed to determine the amount of revenue to be recognized and when it should be recognized: (1) identify the contract or contracts; (2) determine whether the promised goods or services are performance obligations, including whether they are distinct in the context of the contract; (3) measure the transaction price, including the constraint on variable consideration; (4) allocate the transaction price to the performance obligations based on estimated selling prices; and (5) recognize revenue when (or as) each performance obligation is satisfied. SOPHiA DDM Platform The majority of the SOPHiA DDM Platform revenue is derived from each use of the SOPHiA DDM Platform by customers to generate analysis on their patient data. Analysis revenue is recognized as analysis results are made available to the customer on the SOPHiA DDM Platform. The Company recognizes accrued contract revenue in accounts receivable for any analyses performed by customers that have not been invoiced at the reporting date and where the right to consideration is unconditional. Any payments received in advance of customers generating analyses are recorded as deferred contract revenue until the analyses are performed. Customers use the SOPHiA DDM Platform to perform analyses under three different models: dry lab access; bundle access; and integrated solutions. For dry lab contracts, customers use the testing instruments and consumables of their choice and the SOPHiA DDM Platform and algorithms for variant detection and identification. In these arrangements, the Company has identified one performance obligation, which is the delivery of the analysis result to the customer. For bundle arrangements, customers purchase a DNA enrichment kit along with each analysis. Customers use the DNA enrichment kit in the process of performing their own sequencing of each sample. Customers then upload their patient data to the SOPHiA DDM Platform for analysis. In these arrangements, the Company has identified two performance obligations: the delivery of the DNA enrichment kits and the performance of the analyses. Revenue is recognized for the DNA enrichment kits when control of products has transferred to the customer, which is generally at the time of delivery, as this is when title and risk of loss have been transferred. Revenue for the performance of the analyses is recognized on delivery of the analysis results to the customer. Refer to Arrangements with multiple performance obligations below for how revenue is allocated between the performance obligations. Deferred contract revenue balances relating to analyses not performed within 12 months from the date of the delivery date are recognized as revenue. This policy is not based on contractual conditions but on the Company’s experience of customer behavior and expiration of the kits associated with the analyses. For integrated arrangements, customers have their samples processed and sequenced through selected SOPHiA DDM Platform partners within the clinical network and access their data through the SOPHiA DDM Platform. The Company has identified one performance obligation, which is delivery of the analysis results to the customer through the SOPHiA DDM Platform. The Company also sells access to its Alamut software application (“Alamut”) through the SOPHiA DDM Platform. Some arrangements with customers allow customers to use Alamut as a hosted software service over the contract period without the customer taking possession of the software. Other customers take possession of the software, but the utility of that software is limited by access to the Company’s proprietary SOPHiA database, which is provided to the customer on a fixed term basis. Under both models, revenue is recognized on a straight-line basis over the duration of the agreement. The Company also derives revenue from the SOPHiA DDM Platform by providing services to biopharma customers who engage the Company to (i) develop and perform customized genomic analyses and/or (ii) access the database for use in clinical trials and other research projects. The Company does enter into biopharma contracts that contain multiple products or services or non-standard terms and conditions. The biopharma contracts are generally unique in nature and each contract is assessed upon execution. Generally, the primary performance obligation in these arrangements is the delivery of analysis results in the form of a final report, resulting in revenue being recognized, in most cases, upon the issuance of the final report or successful recruitment of clinical trial participants. Workflow materials and services Revenue from workflow materials and services includes all revenue from the sale of materials and services that do not form part of a contract for the provision of platform services. These include the provision of set-up programs and training and the sale of kits and tests that are not linked to use of the platform. Set-up programs and training are typically combined with a customer’s first order prior to the customer beginning to use the SOPHiA DDM Platform. Revenue from services is generally recognized when the services are performed. Revenue from materials is recognized when control of the goods is transferred to the customer, generally at the time of delivery. This category of revenue also includes the revenue from the sale of DNA sequencing automation equipment accounted for under IFRS 16, Leases (“IFRS 16”), leasing and the fees charged for the maintenance of this equipment. Arrangements with multiple performance obligations The Company sells different combinations of analyses, consumables, and services to its customers under its various SOPHiA DDM Platform models. The Company has determined that the stand-alone selling prices for services and DNA enrichment kits are directly observable. For set-up programs and training sold along with dry lab arrangements or bundle arrangements, the stand-alone selling price of these services is determined on a time and materials basis. For DNA enrichment kits sold as part of a bundle, the SSP is based on an expected cost-plus-margin approach of the kit portion of the bundle. The Company has determined that the SSP for the analyses, in both a dry lab arrangement and bundle arrangement, is highly variable and therefore a representative SSP is not discernible from past transactions. As a result, the residual approach is used to determine the stand-alone selling price of the analyses in dry lab arrangements that include services and in bundle arrangements that include DNA enrichment kits and, in some cases, services. The Company also has a small number of bundle contracts with a fixed term that also include providing the customer with DNA sequencing automation equipment, which the Company has determined is an IFRS 16 leasing component. In these arrangements the Company provides DNA sequencing automation equipment to the customer over the fixed term and at completion of the contract term the customer takes possession of the equipment. The Company has determined that it is a dealer lessor and provision of this equipment to the customer is classified as a finance lease. As a result, upon delivery of the leased equipment at the inception of the arrangement, a selling profit is recognized based on the fair value of the underlying equipment less the cost of the equipment. Over the term of the agreement, the minimum lease payment is deducted from the proceeds of the bundle sales in order to reduce the net investment in the corresponding lease receivable over the contract term and interest income is recognized as the discount on the lease receivable unwinds. The remaining proceeds from the contract are accounted for under IFRS 15, Revenue from Contracts with Customers (“IFRS 15”), using the policies described above. Contract Balances Accrued contract revenue Accrued contract revenue is related to unbilled SOPHiA DDM Platform analyses and are recorded in accounts receivable. As of December 31, 2022 and December 31, 2021, accrued contract revenue was $1.5 million and $0.7 million, respectively. The Company recorded no loss allowance related to the accrued contract revenue as of December 31, 2022 and December 31, 2021, respectively Deferred contract costs Deferred contract costs comprise deferred fulfillment costs related to biopharma, prepayments on contracts, and prepaid maintenance costs relating to DNA sequencing automation equipment. Costs are incurred to fulfill obligations under certain contracts once obtained, but before transferring goods or services to the customer. Fulfillment costs are recognized as an asset, provided these costs are not addressed by other accounting standards, if the following criteria are met: (i) the costs relate directly to a contract or an anticipated contract that the Company can specifically identify, (ii) the costs generate or enhance resources of the Company that will be used in satisfying (or continuing to satisfy) performance obligations in the future and (iii) the costs are expected to be recovered. The asset recognized from deferring the costs to fulfill a contract is recorded in the consolidated balance sheet as deferred contract costs within other current assets and amortized on a systematic basis consistent with the pattern of the transfer of the goods or services to which the asset relates, which depends on the nature of the performance obligation(s) in the contract. The amortization of these assets is recorded in cost of revenue. The timing of revenue recognition and billings can result in accrued contract revenue, which are presented within accounts receivable in the consolidated balance sheet and deferred contract revenue which is presented on the face of the consolidated balance sheet. Deferred contract revenue Deferred contract revenue relates to prepayments received from customers before revenue is recognized and is primarily related to SOPHiA DDM Platform analyses invoiced in advance of the customers performing the analyses, deferred Alamut software revenue and progress payments received as part of biopharma contracts. Deferred contract revenue brought forward as of January 1, 2022 and January 1, 2021 amounts to $4.0 million and $2.9 million, respectively. During the twelve months ended December 31, 2022 and 2021 , the Company satisfied the performance obligations associated with that deferred contract revenue to the extent that revenue was recognized of $4.0 million and $2.9 million, respectively. The majority of the platform revenue is derived from contracts with an original expected length of one year or less. However, there are certain biopharma and Alamut contracts in which performance obligations extend over multiple years. The Company has elected to apply the practical expedient not to disclose the value of remaining performance obligations associated with these types of contracts. Disaggregated Revenue When disaggregating revenue, the Company considered all of the economic factors that may affect its revenues. The Company assess its revenues by four geographic regions Europe, the Middle East, and Africa (“EMEA”); North America (“NORAM”); Latin America (“LATAM”); and Asia-Pacific (“APAC”). The following tables disaggregate the Company's revenue from contracts with customers by geographic market (in USD thousands): Year ended December 31, 2022 2021 2020 EMEA $ 34,878 $ 31,583 $ 22,073 NORAM 6,732 4,730 2,923 LATAM 3,003 2,295 2,131 APAC 2,947 1,842 1,273 Total revenue $ 47,560 $ 40,450 $ 28,400 Revenue streams The Company’s revenue from contracts with customers has been allocated to the revenue streams indicated in the table below (in USD thousands): Year ended December 31, 2022 2021 2020 SOPHiA DDM Platform $ 45,679 $ 39,465 $ 27,221 Workflow equipment and services 1,881 985 1,179 Total revenue $ 47,560 $ 40,450 $ 28,400 Workflow equipment and services includes revenues from payments from leased equipment recognized under IFRS 16, Leases, of $0.1 million, $0.2 million, and $0.1 million for the years ended December 31, 2022, December 31, 2021, and December 31, 2020, respectively.

Cost of revenue

Cost of revenue	12 Months Ended
	Dec. 31, 2022
Disclosure Of Cost Of Sales [Abstract]
Cost of revenue	Cost of revenue Accounting policies Cost of revenue comprises costs directly incurred in earning revenue, including computer costs and data storage fees paid to hosting providers, manufacturing costs, materials and consumables, the cost of equipment leased out under finance leases, personnel-related expenses and amortization of capitalized development costs.

Operating expense

Operating expense	12 Months Ended
	Dec. 31, 2022
Analysis of income and expense [abstract]
Operating expense	Operating expense Accounting policies Research and development Research and development costs consist of personnel and related expenses for technology, application, and product development, depreciation and amortization, laboratory supplies, consulting services, computer costs and data storage fees paid to hosting providers related to research and development and allocated overhead costs. These costs are stated net of government grants for research and development and innovation received as tax credits and net of capitalized costs. Government grants for research and development and innovation received as tax credits The Company receives government grants in France for research and development and innovation by way of tax credits. Total government grants for research and development and innovation recognized in the statement of loss amounts to $1.3 million , $1.6 million, $0.8 million for the years ended December 31, 2022, December 31, 2021, and December 31, 2020, respectively. There are no unfulfilled conditions or other contingencies attached to these grants. Selling and marketing costs Selling and marketing costs consist of personnel and related expenses for the employees of the sales and marketing organization, costs of communications materials that are produced to generate greater awareness and utilization of the platform among customers, costs of third-party market research, costs related to transportation and distribution of our products, and allocated overhead costs. These costs are stated net of government grants under the US Paycheck Protection Program (“PPP”) for payroll and/or rental obligations received as a loan that is forgiven if utilized as intended. The Company pays sales commission to its employees for obtaining contracts. These costs are expensed as part of employee compensation in selling and marketing costs. They are not capitalized as contract costs as the commissions either represent bonuses payable for revenue earned in the period or have a service condition attached. General and administrative costs General and administrative costs consist of personnel and related expenses for our executive, accounting and finance, legal, quality, support and human resources functions, depreciation and amortization, professional services fees incurred by these functions, general corporate costs and allocated overhead costs, which include occupancy costs and information technology costs. Operating expense by nature The table presents operating expenses by nature (in USD thousands): For the year ended December 31, 2022 2021 2020 Changes in inventories of finished goods and work in progress $ 47 $ 568 $ (259) Raw materials and consumables used (13,341) (9,650) (3,843) Employee benefit expenses (59,333) (53,802) (36,732) Social charges (11,480) (8,373) (6,983) COVID—salaries reimbursement — — 1,129 Research tax credit 1,292 1,597 763 Share-based compensation (13,613) (8,514) (1,359) Depreciation (3,791) (2,517) (1,758) Amortization (1,780) (1,092) (632) Professional fees (13,837) (11,318) (5,371) Office expenses (6,635) (5,333) (2,006) Travel (3,217) (1,576) (1,361) Marketing (2,213) (1,493) (972) Licenses (3,949) (2,021) (1,647) Less: capitalized software development costs ("Note 17 - Intangible assets”) 5,820 3,858 2,436 Other expense (9,730) (12,381) (7,099) Total $ (135,760) $ (112,047) $ (65,694) Depreciation and amortization have been charged in the following expense categories (in USD thousands): For the year ended December 31, 2022 2021 2020 Depreciation Amortization Depreciation Amortization Depreciation Amortization Cost of revenue $ — $ (1,133) $ — $ (483) $ — $ (111) Research and development costs (1,748) — (1,028) — (727) — Selling and marketing costs (906) — (744) — (543) — General and administrative costs (1,137) (647) (745) (609) (488) (521) Total $ (3,791) $ (1,780) $ (2,517) $ (1,092) $ (1,758) $ (632) The table presents employee costs by function, which consists of “Employee benefit expenses”, “Social charges” and “Share-based compensation” from the operating expense table (in USD thousands): For the year ended December 31, 2022 2021 2020 Research and development costs $ 29,169 $ 23,899 $ 16,109 Selling and marketing costs 20,216 21,659 12,085 General and administrative costs 35,041 25,131 16,880 Total $ 84,426 $ 70,689 $ 45,074

Other operating income (expense

Other operating income (expense), net	12 Months Ended
	Dec. 31, 2022
Other Operating Income Expense Net [Abstract]
Other operating income (expense), net	Other operating income (expense), net Accounting policies The Company records income and expenses that are not regularly occurring or normal business income and expense to other operating income (expense). Other operating income (expense) consists of government grants, gains on disposal of tangible assets, intangible write-offs, and other operating income (expense).

Finance income (expense), net

Finance income (expense), net	12 Months Ended
	Dec. 31, 2022
Finance Expense Net [Abstract]
Finance income (expense), net	Finance income (expense), net December 31, 2022 2021 2020 Interest income $ 1,324 $ 20 $ 96 Total interest income $ 1,324 $ 20 $ 96 Interest on loans — (120) (513) Interest on lease liabilities (422) (225) (121) Other interest (217) (313) (206) Total interest expense $ (639) $ (658) $ (840) Derivative fair value (losses) — (1,444) (384) Foreign exchange gains (losses), net (447) 64 (2,710) Total finance income (expense), net $ 238 $ (2,018) $ (3,838) Accounting policies Interest income consists of interest income earned on cash and cash equivalents, short-term investments, and lease receivables. Interest expense on lease liabilities and loans, which includes, interest on commercial borrowings, and also interest on COVID-19 loans using the effective interest rate method. The foreign exchange gains and losses arise principally on USD cash balances and intercompany receivable balances in the parent company, whose functional currency is the Swiss Franc. The Company had an obligation to pay a success fee linked to a loan that is now repaid. The obligation had many features of a cash-settled share option. It was revalued at fair value at each reporting date using an option pricing model based on a Monte Carlo simulation. This model demands inputs that require the exercise of considerable judgement. Refer to Note 25 - “ TriplePoint success fee ” for additional discussion on the derivative accounting.

Income tax

Income tax	12 Months Ended
	Dec. 31, 2022
Major components of tax expense (income) [abstract]
Income tax	Income tax Critical accounting estimates and judgements Uncertain tax positions The Company files tax returns as prescribed by the tax laws of the jurisdictions in which it operates and therefore subject to tax examination by various taxing authorities. In the normal course of business, the Company is subject to examination by local tax authorities in Switzerland, France, Italy, Brazil, the UK and the US. With the exception of a tax assessment rendered by the French tax authority during an audit of its 2018 and 2019 tax returns as discussed below, t he Company is not aware of any additional issues that could result in any other significant payments, accruals or material deviation from its tax positions. There are no other tax examinations in progress. The Company records tax liabilities or benefits for all years subject to examination based upon management’s evaluation of the facts, circumstances and information available at the reporting date. There is inherent uncertainty in quantifying income tax positions, especially considering the complex tax laws and regulations in each of the jurisdictions in which the Company operates. Accounting policies The Company is subject to taxes in different countries. Taxes and related fiscal assets and liabilities recognized in the Company’s consolidated financial statements reflect management’s best estimate of the outcome based on the facts known at the balance sheet date in each individual country. These facts may include but are not limited to change in tax laws and interpretation thereof in the various jurisdictions where the Company operates. They may have an impact on the income tax as well as the resulting income tax assets and liabilities. Any differences between tax estimates and final tax assessments are charged to the statement of income/loss in the period in which they are incurred. Taxes include current and deferred taxes on income as well as actual or potential withholding taxes on current and expected transfers of income from subsidiaries and tax adjustments relating to prior years. Income tax is recognized in the statement of income/loss, except to the extent that it relates to an item directly taken to other comprehensive income/loss or equity, in which case it is recognized against other comprehensive income/loss or equity, respectively. Current income tax liabilities refer to the portion of the tax on the current year taxable profit (as determined according to the rules of the taxation authorities) and includes uncertain tax liabilities. The Company determines the taxable profit (tax loss), tax bases, unused tax losses, unused tax credits and tax rates consistently with the tax treatment used or planned to be used in its income tax filings if the Company concludes it is probable that the taxation authority will accept an uncertain tax treatment. Otherwise, the Company reflects the effect of uncertainty using either the most likely outcome or the expected value outcome, depending on which method the entity expects to better predict the resolution of the uncertainty. Deferred taxes are based on the temporary differences that arise when taxation authorities recognize and measure assets and liabilities with rules that differ from the accounting policies of the Company’s consolidated financial statements. They also arise on temporary differences stemming from tax losses carried forward. Deferred taxes are measured at the rates of tax expected to prevail when the temporary differences reverse, subject to such rates being substantively enacted at the balance sheet date. Any changes of the tax rates are recognized in the statement of income/loss unless related to items directly recognized against other comprehensive income. Deferred tax liabilities are recognized on all taxable temporary differences excluding non-deductible goodwill. Deferred tax assets are recognized for unused tax losses, unused tax credits and deductible temporary differences to the extent that it is probable that future taxable profits will be available against which they can be used. Future taxable profits are determined based on the reversal of relevant taxable temporary differences. If the amount of taxable temporary differences is insufficient to recognize a deferred tax asset in full, then future taxable profits, adjusted for reversals of existing temporary differences, are considered, on the basis of the business plans for individual subsidiaries in the Company. Deferred tax assets are reviewed at each reporting date and are reduced to the extent that it is no longer probable that the related tax benefit will be realized; such reductions are reversed when the probability of future taxable profits improves. The tax impact of a transaction or item can be uncertain until a conclusion is reached with the relevant tax authority or through a legal process. The Company uses in-house tax experts when assessing uncertain tax positions and seeks the advice of external professional advisors where appropriate. The assessment of the uncertain tax position is done by first making a determination of whether it is more likely than not that a tax position would be sustained upon an examination, and then by calculating the amount of the benefit, of that tax position that meets the more likely than not threshold, that should be recognized in the financial statements. As of December 31, 2022, and 2021, the Company recorded a provi sion of $0.3 million an d $0.1 million for unrecognized tax liabilities including interest and penalties. The Company records interest and penalties related to income tax amounts as a component of income tax expense. France tax audit The Company has been under examination in France for its 2018 and 2019 tax returns. The French tax authority issued a tax assessment in December 2022 that reduced the balance of the Company’s tax losses carryforward in France by $1.8 million ($0.5 million tax effected amount) stemming from a review of the Company’s transfer pricing policy. The tax assessment is subject to appeal. However, the Company has elected to take a conservative approach and adjusted the balance of its deferred tax assets to reflect the reduction in the balance of tax losses carryforward. The tax assessment in France has resulted in no other material tax liability or payment. Presentation of tax (expense) benefits The following table presents the current and deferred tax (expense) benefits (in USD thousands): For the year ended December 31, 2022 2021 2020 Current income tax expense Current year $ (310) $ — $ — Uncertain tax positions 328 (110) (74) Total current income tax expense $ 18 $ (110) $ (74) Deferred income tax (expense) benefit Origination and reversal of temporary differences $ 118 $ (58) $ 1,960 Total deferred income tax (expense) benefit $ 118 $ (58) $ 1,960 Total income tax (expense) benefit $ 136 $ (168) $ 1,886 The following table presents the reconciliation of the expected tax expense to the tax expense report in the statement of loss (in USD thousands): For the year ended December 31, 2022 2021 2020 Loss before tax $ (87,585) $ (73,507) $ (41,225) Tax at Swiss statutory rate 11,749 9,907 5,541 Effect of tax rates in foreign jurisdictions (292) (218) (177) Tax effect of: Unrecognized deferred tax assets (9,386) (9,077) (3,276) Income not subject to tax (expense not deductible for tax purposes) (1,940) (805) 41 Uncertain tax positions 328 (110) (74) Recognition of deferred tax assets from previously unrecognized tax assets 509 — — 2018-2019 French tax assessment (427) — — Other (405) 135 (169) Income tax (expense)/benefit $ 136 $ (168) $ 1,886 Movement in the deferred tax balances During the year ended December 31, 2022, the Company recognized deferred tax assets for its foreign subsidiaries due to intercompany transfer pricing arrangements that will assure realization of their respective deferred tax assets in each country. The following table presents the changes in the Company’s deferred tax assets and deferred tax liabilities (in USD thousands): Depreciation & Bad debt reserves Accrued pension ROU asset Lease liability Other Net operating loss Total January 1, 2022 $ (29) $ 341 $ 44 $ (352) $ 630 $ 96 $ 1,260 $ 1,990 Recognized in profit or loss (50) (324) 26 60 (119) 725 (201) 117 Recognized in OCI — — (59) — — — — (59) Currency translation differences (1) (17) (2) (10) 31 (109) (108) December 31, 2022 $ (80) $ — $ 9 $ (302) $ 511 $ 852 $ 950 $ 1,940 Deferred tax assets 9 511 940 950 2,410 Deferred tax liabilities (80) — — (302) — (88) — (470) Depreciation & Bad debt reserves Accrued pension ROU asset Lease liability Other Net operating loss Total January 1, 2021 $ 288 $ 433 $ 35 $ (311) $ 301 $ (10) $ 1,378 $ 2,114 Recognized in profit or loss (309) (65) 12 (34) 331 38 (31) (58) Currency translation differences (8) (27) (3) (7) (2) 68 (87) (66) December 31, 2021 $ (29) $ 341 $ 44 $ (352) $ 630 $ 96 $ 1,260 $ 1,990 Deferred tax assets — 341 44 — 630 361 1,260 2,636 Deferred tax liabilities (29) — — (352) — (265) — (646) Unrecognized deferred tax assets As of December 31, 2022 and December 31, 2021, the Company recognized deferred tax assets to the extent that it was probable that they would be realized. The following table consists of the deferred tax assets that have not been recognized because it is not probable that there will be future taxable profits to use these benefits (in USD thousands): December 31, 2022 2021 Gross amount Tax effect Gross amount Tax effect Deductible temporary differences $ 3,385 $ 511 $ 5,101 $ 729 Net operating loss carryforwards 263,486 34,224 202,394 28,597 Total $ 266,871 $ 34,735 $ 207,495 $ 29,326 Net operating loss carryforwards As of December 31, 2022 and December 31, 2021, the Company had various net operating loss (“NOL”) carryforwards in Switzerland, France, the UK, the US, and Brazil that are available to reduce future taxable income and income taxes, the majority of which will expire at various dates through 2028. As of December 31, 2022 and December 31, 2021, the Company had the following expiring amounts of unrecognized NOL carryforwards (in USD thousands): December 31, 2022 2021 One year $ 12,007 $ 7,625 Two years 16,261 12,170 Three years 15,561 16,482 Four years 23,515 15,772 Thereafter and unlimited 196,142 150,345 Net operating loss carryforwards $ 263,486 $ 202,394 Future realization of the tax benefits of existing temporary differences and NOL carryforwards ultimately depends on the existence of sufficient taxable income within the carryforward period. As of December 31, 2022, the Company performed an evaluation to determine the likelihood of realization of these tax benefits. In assessing the realization of the deferred tax assets, the Company considered whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The Company considered all available evidence, both positive and negative, which included the results of operations for the current and preceding years. The Company determined that it was not possible to reasonably quantify future taxable income and determined that it is not probable that all of the deferred tax assets will be realized in Switzerland and Brazil but has recognized deferred tax assets in France, the UK and the US. Unrecognized deferred tax liability on retained earnings of subsidiaries The Company does not provide for foreign income and withholding taxes, Swiss income taxes or tax benefits on the excess of the financial reporting basis over the tax basis of its investments in foreign subsidiaries to the extent that such amounts are indefinitely reinvested to support operations and continued growth plans outside of Switzerland. The Company reviews its plan to indefinitely reinvest on a periodic basis. In making its decision to indefinitely reinvest, the Company evaluates its plans of reinvestment, its ability to control repatriation and to mobilize funds without triggering basis differences, and the profitability of its Swiss operations and their cash requirements and the need, if any, to repatriate funds. If the assessment of the Company with respect to any earnings of its foreign subsidiaries’ changes, deferred Swiss income taxes, foreign income taxes, and foreign withholding taxes may have to be accrued. Based on its assessment, the Company plans to indefinitely reinvest any undistributed foreign earnings as at December 31, 2022 unless repatriation of foreign earnings, if any, required for cash management purposes. In addition, the determination of any unrecognized deferred tax liabilities for temporary differences related to the Company’s investment in foreign subsidiaries is not practicable.

Loss per share

Loss per share	12 Months Ended
	Dec. 31, 2022
Earnings per share [abstract]
Loss per share	Loss per share The Company’s shares comprised of ordinary shares. Each share has a nominal value of $0.05 (CHF 0.05). The basic loss per share is calculated by dividing the net loss attributable to shareholders by the weighted average number of shares in issue during the period. The table presents the loss for the year ended December 31, 2022, 2021, and 2020, respectively (in USD thousands, except shares and loss per share): Year ended December 31, 2022 2021 2020 Net loss attributed to shareholders $ (87,449) $ (73,675) $ (39,339) Weighted average number of shares in issue 64,099,213 55,299,863 42,350,757 Basic and diluted loss per share $ (1.36) $ (1.33) $ (0.93)

Cash and cash equivalents

Cash and cash equivalents	12 Months Ended
	Dec. 31, 2022
Cash and cash equivalents [abstract]
Cash and cash equivalents	Cash and cash equivalents Accounting policies Cash and cash equivalents include cash on hand, deposits held at call with external financial institutions and other short- term highly liquid investments with original maturities of three months or less. They are both readily convertible to known amounts of cash and so near their maturity that they present insignificant risk of changes in value because of changes in interest rates. The following table presents the allocation between the Company’s cash and cash equivalents (in USD thousands): December 31, 2022 2021 Cash $ 25,820 $ 39,578 Cash equivalents 135,485 153,384 Cash and cash equivalents $ 161,305 $ 192,962 Designated cash In July 2021, the Company designated $30.0 million to a separate bank account to be used exclusively to settle potential liabilities arising from claims against Directors and Officers covered under the Company’s Directors and Officers Insurances Policy (“D&O Policy”). Setting up the designated account has significantly reduced the premiums associated with the D&O Policy. The Company expects to continue to designate this cash balance for this sole use under the current D&O Policy.

Term deposits

Term deposits	12 Months Ended
	Dec. 31, 2022
Disclosure Of Term Deposits [Abstract]
Term deposits	Term deposits The following table presents the allocation between the Company’s term deposits (in USD thousands): December 31, 2022 2021 Term deposits, over 3 months, up to 12 months $ 17,307 $ 72,357 Total term deposits $ 17,307 $ 72,357

Accounts receivable

Accounts receivable	12 Months Ended
	Dec. 31, 2022
Trade and other receivables [abstract]
Accounts receivable	Accounts receivable Significant accounting estimates and judgements The Company has adopted the simplified method indicated in IFRS 9, Financial Instruments (“IFRS 9”), to build its allowance for expected credit losses (“ECL”). The Company uses a matrix based on a calculation of collectability rates according to historical accounts receivable. Allowance is made for lifetime expected credit losses as invoices are issued. The amount of allowance initially recognized is based on historical experience, tempered by expected changes in future cash collections, due to, for example, expected improved customer liquidity or more active credit management. Accounting policies Accounts receivable balances are non-interest bearing and payment terms are generally under agreements with payment terms of up to 180 days. The Company’s customers are mainly government-owned or government-funded hospitals and laboratories with a low credit risk. The Company has had minimal instances of actual credit losses and considers that this will continue to be the case. The following table presents the accounts receivable and lease receivable less the expected credit loss (in USD thousands): December 31, 2022 December 31, 2021 Accounts receivable $ 6,060 $ 7,060 Accrued contract revenue 1,499 657 Lease receivable 185 237 Allowance for expected credit losses (1,095) (1,676) Net accounts receivable $ 6,649 $ 6,278 The movement in the allowance for expected credit losses in accounts receivable is presented below (in USD thousands): 2022 2021 As of January 1 $ 1,676 $ 2,664 Increase 404 1,273 Reversals (804) (1,612) Write-off (67) (572) Currency translation differences (114) (77) As of December 31 $ 1,095 $ 1,676 As of December 31, 2022 and 2021 , the Company’s largest customer balance represented 15% and 18% of accounts receivable. All customer balances that individually exceeded 1% of accounts receivable in aggregate amounted to $5.4 million and $4.6 million as of December 31, 2022 and 2021 , respectively. Accounts receivable includes amounts receivable that relate to leases. The Company is the lessor under finance leases related to the leasing out of DNA sequencing automation equipment. The Company recorded no long-term lease receivables as of December 31, 2022 and 2021 , respectively. As of December 31, 2022 and 2021 , the Company had recorded net lease receivables in the amount of $0.2 million and $0.2 million.

Inventory

Inventory	12 Months Ended
	Dec. 31, 2022
Classes of current inventories [abstract]
Inventory	Inventory Accounting policies Raw materials and finished goods are stated at the lower of cost calculated using the first-in, first-out (“FIFO”) method and net realizable value. Work in progress is stated at the lower of its weighted average cost and net realizable value. Cost comprises direct materials, direct labor and an appropriate proportion of variable and fixed overhead expenditure, the latter being allocated on the basis of normal operating capacity. Inventory consists of the following (in USD thousands): December 31, 2022 2021 Raw materials $ 5,195 $ 5,105 Work in progress 1,340 1,330 Finished goods 124 87 Provision (1,503) (793) Total $ 5,156 $ 5,729 Inventory provision movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): 2022 2021 As of January 1 $ (793) $ (713) Increase in provision (697) (105) Currency Translation Adjustment (13) 25 As of December 31 $ (1,503) $ (793)

Prepaids and other current asse

Prepaids and other current assets	12 Months Ended
	Dec. 31, 2022
Prepaids And Other Current Assets [Abstract]
Prepaids and other current assets	Prepaids and other current assets The following table presents the other current assets (in USD thousands): December 31, 2022 December 31, 2021 Deferred contract costs $ — $ 150 Prepayments 3,703 3,943 VAT receivable 1,244 811 Government grants receivable 160 — Other 731 625 Total $ 5,838 $ 5,529

Property and equipment

Property and equipment	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about property, plant and equipment [abstract]
Property and equipment	Property and equipment Accounting policies Property and equipment include leasehold improvements, computer hardware, machinery and furniture and fixtures. Property and equipment are shown on the balance sheet at their historical cost. The cost of an asset, less any residual value, is depreciated using the straight-line method over the useful life of the asset. For this purpose, assets with similar useful lives have been grouped as follows: • Leasehold improvements—Shorter of the useful life of the asset or the remaining term of the lease • Computer hardware— Three • Machinery and equipment—Five years • Furniture and fixtures—Five years Useful lives, components, and residual amounts are reviewed annually. Such a review takes into consideration the nature of the assets, their intended use, including but not limited to the closure of facilities, and the evolution of the technology and competitive pressures that may lead to technical obsolescence. Depreciation of property and equipment is allocated to the appropriate headings of expenses by function in the statement of loss. Reviews of the carrying amount of the Company’s property and equipment are performed when there is an indication of impairment. If any such indication exists, then the asset’s recoverable amount is estimated. The recoverable amount of an asset is the greater of its value in use and its fair value less costs of disposal. In assessing the value in use, the estimated future cash flows are discounted to their present value, based on the time value of money and the risks specific to the country where the assets are located. For the year ended December 31, 2022 and 2021 , the Company recorded $0.1 million and $0.5 million in accrued expense related to amounts to be paid within the next 12 months, respectively. Property and equipment, net movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): Leasehold improvements Machinery and equipment Computer hardware Furniture and fixtures Total January 1, 2022 $ 3,260 $ 1,116 $ 1,855 $ 1,007 $ 7,238 Additions 2,895 480 147 222 3,744 Disposals — — (319) (113) (432) Currency Translation Adjustment 27 30 (50) (8) (1) December 31, 2022 $ 6,182 $ 1,626 $ 1,633 $ 1,108 $ 10,549 Accumulated depreciation January 1, 2022 $ (570) $ (418) $ (1,228) $ (359) $ (2,575) Additions (588) (224) (273) (206) (1,291) Disposals — — 319 113 432 Currency Translation Adjustment (7) (23) 39 5 14 December 31, 2022 $ (1,165) $ (665) $ (1,143) $ (447) $ (3,420) Net book value at December 31, 2022 $ 5,017 $ 961 $ 490 $ 661 $ 7,129 Leasehold improvements Machinery and equipment Computer hardware Furniture and fixtures Total January 1, 2021 $ 890 $ 615 $ 1,799 $ 623 $ 3,927 Additions 2,447 608 421 420 3,896 Disposals (49) (85) (294) (31) (459) Currency Translation Adjustment (28) (22) (71) (5) (126) December 31, 2021 $ 3,260 $ 1,116 $ 1,855 $ 1,007 $ 7,238 Accumulated depreciation January 1, 2021 $ (258) $ (398) $ (1,230) $ (269) $ (2,155) Additions (352) (119) (341) (130) (942) Disposals 29 85 292 31 437 Currency Translation Adjustment 11 14 51 9 85 December 31, 2021 $ (570) $ (418) $ (1,228) $ (359) $ (2,575) Net book value at December 31, 2021 $ 2,690 $ 698 $ 627 $ 648 $ 4,663

Intangible Assets

Intangible Assets	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about intangible assets [abstract]
Intangible Assets	Intangible Assets Critical accounting estimate and judgements Goodwill The Company operates as one segment or as a single cash-generating unit (“CGU”). As a single CGU, goodwill is tested by considering its recoverability in terms of the entire business. Management assesses the recoverable value of goodwill by comparing the Company’s equity value, either from observable market prices or based on discounted cash flow forecasts, to the net assets as reported in the Company’s consolidated financial statements. The value as of October 1, 2022 was based on the Company’s discounted cash flow projections, which in turn were based on historical results and ratios updated to reflect management’s expectations of future growth and profitability and discounted using a weighted average cost of capital derived from an analysis of comparable selected public companies. The value as of October 1, 2021 was based on the Company’s market capitalization which is a factor of the Company’s outstanding shares multiplied by the price of the Company’s stock on October 1, 2021 . Capitalized internally developed software costs Capitalized costs are based on the employment costs of individuals working on software development and based on timesheets. Special attention is paid to distinguishing between costs incurred on developing new software or software upgrades, which may be eligible for capitalization, and costs incurred in maintenance and in the correction of problems, which is not eligible. Judgement is required in identifying whether individual projects meet all of the criteria required to permit capitalization, in particular, whether the software will generate probable future economic benefits. Accounting policies Goodwill Goodwill is initially measured as the difference between the aggregate of the value of the consideration transferred and the fair value of net assets acquired. Goodwill is not amortized but it is tested for impairment annually, or more frequently if events or changes in circumstances indicate that it might be impaired and is carried at cost less accumulated impairment losses. Gains and losses on the disposal of an entity include the carrying amount of goodwill relating to the entity sold. Impairment testing Intangible assets are allocated to CGUs for the purpose of impairment testing. The allocation is made to those CGUs or groups of CGUs that are expected to benefit from the business combination in which the goodwill arose. The CGUs or groups of CGUs are identified at the lowest level at which goodwill is monitored for internal management purposes, being the operating segments. As the Company operates as a single operating segment or CGU, the Company has only a single cash generating unit for impairment testing. Management assesses the recoverable value of goodwill by comparing the value of the Company equity value, either inferred from the public prices of share issues based on the fair value less cost of disposal (“FVLCOD”) method or based on discounted cash flow forecasts, with the net assets as reported in its consolidated financial statements based on the value in use (“ViU”) method). The Company typically compares the two methods and utilizes the greater recoverable amount for the purposes of its impairment testing. Impairment testing is performed on an annual basis as of October 1 . The discounted cash flow approach involves key assumptions that leave considerable scope for judgement. The Company used the discounted cash flow method for the fiscal year ended as of December 31, 2022. Purchased software The costs of accessing software services are not capitalized if the Company does not have any contractual right to take possession of the software at any time during the term of the agreement and it is not feasible for the Company either to run the software on its own hardware or to contract with a third party unrelated to the vendor. Such costs represent software as a service costs and are expensed as incurred. The Company does capitalize software implementation costs, such as fees paid to outside consultants to set up a software arrangement. For cloud computing costs, the Company capitalized costs for certain configuration and customization costs paid by a customer in a cloud computing or hosting arrangement. The guidance aligns the accounting treatment of these costs incurred in a hosting arrangement treated as a service contract with the requirements for capitalization and amortization costs to develop or obtain an intangible asset. Purchased software and associated capitalized costs are amortized using the straight-line method over an estimated life of five years. Capitalized internally developed software costs Costs incurred in the internal development of software are capitalized as intangible assets when the criteria required by IAS 38 as set out below. Software development costs consist entirely of capitalized internally generated costs that are directly attributable to the design, testing and enhancement of identifiable and unique software applications and products controlled by the Company and incorporated principally within the Company’s SOPHiA DDM Platform. They are recognized as intangible assets where the following criteria are met: • it is technically feasible to complete software so that it will be available for use; • management intends to complete the software and use or sell it; • there is an ability to use or sell the software; • it can be demonstrated how the software will generate probable future economic benefits; • adequate technical, financial and other resources to complete the development and to use or sell the software are available, and; • the expenditure attributable to the software during its development can be reliably measured. Directly attributable costs that are capitalized as part of the software comprise principally employee costs. Capitalized development costs are recorded as intangible assets and amortized from the point at which the asset is ready for use on a straight-line basis over its expected useful life. Capitalized software development costs are amortized using the straight-line method over an estimated life of five years. The Company considers that it is only since the beginning of 2020 that development costs have fulfilled the criteria for recognition as intangible assets set out in IAS 38. Intangible assets, net movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): Goodwill Purchased software Capitalized internally developed software costs Total intangible assets January 1, 2022 $ 8,298 $ 3,090 $ 6,359 $ 17,747 Additions — 464 5,820 6,284 Disposals — — (80) (80) Currency Translation Adjustment (110) (24) 92 (42) December 31, 2022 $ 8,188 $ 3,530 $ 12,191 $ 23,909 Accumulated amortization January 1, 2022 $ — $ (1,432) $ (642) $ (2,074) Additions — (618) (1,162) (1,780) Disposals — — 7 7 Currency Translation Adjustment — (2) (97) (99) December 31, 2022 $ — $ (2,052) $ (1,894) $ (3,946) Net book value at December 31, 2022 $ 8,188 $ 1,478 $ 10,297 $ 19,963 Goodwill Purchased software Capitalized internally developed software costs Total intangible assets January 1, 2021 $ 8,598 $ 3,071 $ 2,621 $ 14,290 Additions — 130 3,858 3,988 Disposals — — (30) (30) Currency Translation Adjustment (300) (111) (90) (501) December 31, 2021 $ 8,298 $ 3,090 $ 6,359 $ 17,747 Accumulated amortization January 1, 2021 $ — $ (889) $ (119) $ (1,008) Additions — (565) (527) (1,092) Currency Translation Adjustment — 22 4 26 December 31, 2021 $ — $ (1,432) $ (642) $ (2,074) Net book value at December 31, 2021 $ 8,298 $ 1,658 $ 5,717 $ 15,673 Goodwill arose from the Company’s acquisition of Interactive Biosoftware (“IBS”) in June 2018. Through this acquisition the Company added Alamut (a genomic mutation interpretation software) to its existing SOPHiA DDM Platform. Goodwill is tested for impairment on an annual basis as of October 1 and at the occurrence of a potential indication of impairment. A triggering assessment is performed each quarter to ensure no occurrence of impairment triggering events. As of December 31, 2022 and 2021 , respectively, no impairment charges were recorded related to the Company’s goodwill. As of October 1, 2021 the Company utilized the equity method (“FVLCOD”) to perform its annual assessment. The estimated equity value of the Company was $1,200.5 million, which exceeds the reported net assets of the Company of $289.7 million at that date by $910.8 million. As of October 1, 2022 the Company utilized a discounted cash flow (“ViU”) method to perform its annual assessment. The Company assessed both the value of goodwill and intangibles using the discounted cash flow method. The Company used the discounted cash flow method in its annual assessment in 2022 given the significant drop in its share price from January 1, 2022, which resulted in a decline in the market capitalization of the Company. The C ompany computed the value of the CGU using a discounted cash flow analysis. The discounted cash flow analysis used a forecast of seven years in order to project to a point at which the Company’s financial profile is expected to be more mature, which will allow for a more accurate valuation of the recoverable amount of the CGU. The basis of the projection for the discounted cash flow analysis was an internal plan reviewed and approved by management. The Company based its forecast on an expected compound annual growth rate (“CAGR”) of revenue and applied a weighted average cost of capital (“WACC”) and a terminal free cash flow growth rate to the discounted cash flow projections to calculate its CGU’s value. The Company performed a sensitivity analysis over the WACC, the terminal free cash flow growth rate, and the revenue CAGR. The Company used a WACC of 12% that was consistent with the range used in publicly available analyst valuations. The Company used a terminal free cash flow growth rate of 3% based on an internal assessment of historical sustainable market growth rates and historical GDP growth figures that was consistent with the range of rates used in publicly available analyst valuations. The Company performed a sensitivity analysis on the WACC and the terminal free cash flow growth rate to determine the impact on the valuation. The Company determined that the level of WACC and cash flow growth rate at which an impairment of the CGU would occur are 20% for the WACC and a negative cash flow growth rate, respectively. The Company projected revenue over the seven-year period at a CAGR of 37%, which is consistent with internal forecasts reviewed and approved by Management. The Company performed a sensitivity analysis to determine the CAGR at w hich an impairment would occur. The Company determined that at a CAGR of 25% over a seven-year period an impairment of the CGU would occur. On the basis of the analyses performed, the Company concludes that the recoverable amount exceeds the carrying amount of the goodwill and no impairment is needed as of December 31, 2022 and December 31, 2021.

Leases

Leases	12 Months Ended
	Dec. 31, 2022
Presentation of leases for lessee [abstract]
Leases	Leases Accounting policies Lessee The Company assesses at inception of the contract whether a contract is or contains a lease. This assessment involves determining whether the Company obtains substantially all the economic benefits from the use of that asset, and whether the Company has the right to direct the use of the asset. When these conditions are met, the Company recognizes a right-of-use (“ROU”) asset and a lease liability at the lease commencement date, except for short-term leases of 12 months or less, which are expensed in the statement of income/loss on a straight-line basis over the lease term. At inception, the ROU asset comprises the initial lease liability, initial direct costs, and any obligations to refurbish the asset, less any incentives granted by the lessors. The ROU asset is depreciated over the shorter of the duration of the lease contract (including contractually agreed optional extension periods whose exercise is deemed to be reasonably certain) and the useful life of the underlying asset. The ROU asset is subject to testing for impairment if there is an indicator for impairment, as for owned assets. The lease liability is initially measured at the present value of the lease payments that are not paid at the commencement date, discounted using the interest rate implicit in the lease or, if that is not readily determinable, the incremental borrowing rate (“IBR”) at the lease commencement date. The IBR is the rate of interest that the Company would have to pay to borrow over a similar term, and with a similar security, the funds necessary to obtain an asset of a similar value to the ROU asset in a similar economic environment. Lease payments can include fixed payments; variable payments that depend on an index or rate known at the commencement date; and extension option payments or purchase options that the Company is reasonably certain to exercise. The lease liability is subsequently measured at amortized cost using the effective interest rate method and remeasured (with a corresponding adjustment to the related ROU asset) when there is a change in future lease payments due to renegotiation, changes in an index or rate or a reassessment of options. Some of the Company’s leases include options to extend the lease, and these options are included in the lease term to the extent they are reasonably certain to be exercised. Lessor The Company leases out laboratory equipment to certain customers. These leases are classified as finance leases as the Company transfers substantially all the risks and rewards incidental to ownership of the asset to the customer. At the commencement of the lease term, the Company records revenue and the associated costs of sales, being the sale proceeds at fair value of the asset (computed at cost plus a margin) and the cost of the asset, derecognizes the leased asset from inventory, and recognizes a finance lease receivable in the balance sheet equal to the net investment in the lease. Company leases During the year ended December 31, 2022, the Company entered into one significant lease amendment as described above. Rolle office On March 3, 2021, the Company entered into a 120-month lease for office space in Rolle, Switzerland primarily to support the expansion of the research and development department. The lease in total is for approximately 65,860 square feet, including an additional 21,258 square feet based on a lease amendment as described below, with the Company gaining access to areas on prescribed dates. The Company gained access to 11,840 square feet on July 1, 2021. The Company gained access to 7,535 square feet on January 1, 2022 and will gain access to the remaining 21,258 square feet on February 1, 2023. The expected lease commitments resulting from this contract are less than $0.1 million in 2021, $0.5 million in 2022, $1.0 million in 2023 onwards, and $1.14 million from 2024 onward. The expected lease commitments are linked to changes in the Swiss Consumer Price Index as published by Swiss Federal Statistical Office. On January 25, 2022, the Company entered into an amendment to the lease for office space in Rolle, Switzerland. The amendment provides the Company with an additional floor of approximately 21,258 square feet with lease commencement initiating on April 1, 2022. Upon commencement of the lease, the Company recorded a right-of-use asset of $4.5 million and a lease liability of $4.5 million. The Company makes fixed payments and additional variable payments depending on the usage of the asset during the contract period. Upon commencement of the lease, the Company recorded a ROU asset of $7.7 million and a lease liability of $8.5 million. The difference between the ROU and lease liability of $0.8 million is driven by lease incentives and expected restoration costs. Boston office On August 9, 2021, the Company entered into a 40-month new lease for office space in Boston, Massachusetts to support the expansion of the Company’s growth in the United States. The lease in total for the expansion of the Boston office is approximately 9,192 square feet. The expected lease commitments resulting from this contract are $0.5 million a year starting in 2022 through the end of the lease in 2024. The Company makes fixed payments and additional variable payments depending on the usage of the asset during the contract period. Upon commencement of the lease, the Company recorded a right-of-use asset of $1.2 million and a lease liability of $1.4 million. The difference between the ROU and lease liability of $0.2 million is driven by lease incentives. Leases Generally, lease terms for office buildings are between one e of $0.2 million a nd $0.3 million for the years ended December 31, 2022 and 2021, respectively. The Company has lease liabilities amounting to $14.7 million and $10.8 million for the years ended December 31, 2022 and 2021, respectively, that are linked to consumer price indices in Switzerland and France. The future cash flow in relation to short-term leases and leases of low value assets is disclosed in Note 29 – “Commitments and contingencies.” The future cash flow in relation to leases accounted for under IFRS 16 is disclosed in Note 30 – “Financial instruments.” The Company has several leases with extension and termination options. Management determines, on the basis of the business needs, whether they expect to exercise these options. The lease liability is initially measured at the present value of the lease payments that are not paid at the commencement date, discounted using the interest rate implicit in the lease or, if that is not readily determinable, the IBR at the lease commencement date. The IBR is the rate of interest that the Company would have had to pay to borrow over a similar term, and with a similar security, the funds necessary to obtain an asset of a similar value to the ROU asset in a similar economic environment. On the basis of this policy, the IBRs used by the Company to discount lease payments outstanding at December 31, 2022 and 2021, respectively, in the countries in which it has recognized right-of-use assets and lease liabilities have been in the range of 2.61% to 3.47% and 2.61% to 3.47%, respectively. The following table presents the movements in the ROUs (in USD thousands): 2022 2021 As of January 1 $ 11,292 $ 3,767 Additions 5,388 9,205 Depreciation charge (2,500) (1,575) Currency translation effects 88 (105) As of December 31 $ 14,268 $ 11,292 The following table presents the movements in the lease liabilities (in USD thousands): 2022 2021 As of January 1 $ 13,059 $ 3,919 Additions 5,441 10,165 Cash outflows (principle and interest) (2,316) (1,143) Non-cash interest 422 225 Currency translation effects 137 (107) As of December 31 $ 16,743 $ 13,059

Accounts payable

Accounts payable	12 Months Ended
	Dec. 31, 2022
Subclassifications of assets, liabilities and equities [abstract]
Accounts payable	Accounts payable Accounts consist of the following (in USD thousands): December 31, 2022 December 31, 2021 Trade payables $ 2,170 $ 2,337 Employee related payables 3,655 3,509 VAT and sales taxes 356 891 Total $ 6,181 $ 6,737

Accrued expenses

Accrued expenses	12 Months Ended
	Dec. 31, 2022
Accrued Expenses [Abstract]
Accrued expenses	Accrued expenses Accrued expenses consist of the following (in USD thousands): December 31, 2022 December 31, 2021 Accrued Compensation $ 10,268 $ 9,148 Accrued Professional fees 2,162 2,743 Accrued inventory purchases 315 2,472 Accrued IT support 22 25 Accrued Legal fees 287 125 Accrued Other 1,451 1,459 Total $ 14,505 $ 15,972

Other non-current assets

Other non-current assets	12 Months Ended
	Dec. 31, 2022
Miscellaneous non-current assets [abstract]
Other non-current assets	Other non-current assets Other non-current assets consist of the following (in USD thousands): December 31, 2022 2021 Research tax credit receivable $ 3,342 $ 2,295 Guarantee deposit 941 1,405 Total $ 4,283 $ 3,700

Post-employment benefits

Post-employment benefits	12 Months Ended
	Dec. 31, 2022
Disclosure Of Information About Post Employment Benefits [Abstract]
Post-employment benefits	22. Post-employment benefits Significant accounting estimates and judgements The liability or asset recognized in the balance sheet in respect of defined benefit pension plans is the present value of the defined benefit obligation at the end of the reporting period less the fair value of plan assets. The defined benefit obligation is calculated annually by independent actuaries using the projected unit credit method. The present value of the defined benefit obligation is determined by discounting the estimated future cash outflows using interest rates of high-quality corporate bonds that are denominated in the currency in which the benefits will be paid, and that have terms approximating to the terms of the related obligation. In countries where there is no deep market in such bonds, the market rates on government bonds are used. The net interest cost is calculated by applying the discount rate to the net balance of the defined benefit obligation and the fair value of plan assets. This cost is included in employee benefit expense in the statement of income/loss. Remeasurement gains and losses arising from experience adjustments and changes in actuarial assumptions are recognized in the period in which they occur, directly in other comprehensive income. The remeasurement gains and losses are included in retained earnings in the statement of changes in equity and in the balance sheet. Changes in the present value of the defined benefit obligation resulting from plan amendments or curtailments are recognized immediately in income as past service costs. For defined contribution plans, the Company pays contributions to publicly or privately administered pension insurance plans. Employee contributions to these plans is voluntary and these contributions are matched by the employer. The Company has no further payment obligations once the contributions have been paid. The contributions are recognized as employee benefit expense when they are due. Prepaid contributions are recognized as an asset to the extent that a cash refund or a reduction in the future payments is available. Contributions are charged to the statement of income/loss as incurred. Accounting policies The Company operates defined benefit and defined contribution pension plans. Funded schemes are generally funded through payments to insurance companies or trustee-administered funds, determined by periodic actuarial calculations. A defined contribution plan is a pension plan under which the Company pays fixed contributions into a separate entity (a fund) and has no legal or constructive obligations to pay further contributions if the fund does not hold sufficient assets to pay all employees the benefits relating to employee service in the current and prior periods. A defined benefit plan is a pension plan that is not a defined contribution plan. Typically, defined benefit plans define an amount of pension benefit that an employee will receive on retirement, usually dependent on one or more factors such as age, years of service and compensation. The actual return on plan assets, excluding interest income measured at the discount rate, is recognized in other comprehensive income/loss within defined benefit plan remeasurements. The Company has a funded defined benefit plan in Switzerland, an unfunded defined benefit plan in France and a defined contribution plans in the US. The Company has no occupational pension plans in the UK and Brazil. Swiss pension plan The Company contracted with the Swiss Life Collective BVG Foundation based in Zurich for the provision of occupational benefits. All benefits in accordance with the regulations are reinsured in their entirety with Swiss Life SA within the framework of the corresponding contract. This pension solution fully reinsures the risks of disability, death and longevity with Swiss Life. Swiss Life invests the vested pension capital and provides a 100% capital and interest guarantee. The pension plan is entitled to an annual bonus from Swiss Life comprising the effective savings, risk and cost results. Although the amount of ultimate pension benefit is not defined, certain legal obligations of the plan create constructive obligations on the employer to pay further contributions to fund an eventual deficit; this results in the plan nevertheless being accounted for as a defined benefit plan. French pension plan In France, the bulk of pensions are paid by national pension schemes, which are unfunded. In addition, French employers are obliged by law to pay a retirement indemnity. Its amount depends on the last salary of the employee and on the period of activity with its employer. Rights to this benefit are acquired during the service life with the same employer on the condition that the employee will be with its employer at retirement date; it means that the rights are only vested on retirement date. This indemnity is in substance a defined benefit plan. The following table provides additional details on the defined pension plans’ funded status (in USD thousands): December 31, 2022 2021 Present value of defined benefit obligation $ (19,252) $ (17,889) Fair value of plan assets 16,577 13,436 Net pension liability $ (2,675) $ (4,453) The following table presents the movement in the defined benefit obligation (in USD thousands): 2022 2021 Funded Unfunded Total Funded Unfunded Total January 1 $ (17,686) $ (203) $ (17,889) $ (15,773) $ (165) $ (15,938) Service Cost (1,759) (90) (1,849) (1,054) (80) (1,134) of which current service cost (1,873) (90) (1,963) (1,382) (80) (1,462) of which past service cost 114 — 114 328 — 328 Interest expense (154) (2) (156) (49) (1) (50) Actuarial gains (losses) 2,110 250 2,360 471 26 497 Actual plan participants’ contributions (1,361) — (1,361) (1,171) — (1,171) Transfers (in) out due to (joiners) leavers (551) — (551) (651) — (651) Currency translation differences 180 14 194 541 17 558 December 31 $ (19,221) $ (31) $ (19,252) $ (17,686) $ (203) $ (17,889) The service cost and interest expense are charged to the statement of income/loss as pension cost. Actuarial gains (losses) are credited or charged to other comprehensive income (loss) as defined benefit plan remeasurements. As of December 31, 2022, the Swiss and French plans had 248 and 102 act ive members, respectively. As of December 31, 2021, the Swiss and French plans had 252 and 105 active members, respectively. As a result of the reduction in conversion factors, the Company incurred a past service cost gain of $0.1 million for the year ended December 31, 2022. The following table presents the movement in the defined benefit plans’ assets (in USD thousands): 2022 2021 As of January 1 $ 13,436 $ 10,780 Interest income 125 39 Return on plan assets, excl. interest income (204) (32) Administrative expenses (71) (62) Employer contributions 1,452 1,257 Employee contributions 1,361 1,171 Transfers in (out) due to joiners (leavers) 551 651 Currency translation differences (73) (368) As of December 31 $ 16,577 $ 13,436 The following table presents the defined benefit plan assets, which include the following (in USD thousands): December 31, 2022 2021 Cash $ 664 $ 528 Insurance policies 15,913 12,908 Total $ 16,577 $ 13,436 The Swiss Life Collective BVG Foundation, to which the Swiss pension plan is affiliated, manages its funds in the interests of all members, with due attention to the priorities of liquidity, security, and return. The Company’s pension plan benefits from the economies of scale and diversification of risk available through this affiliation. The Company has no influence over the investment policy. The follow table presents the pension costs recognized in statement of loss (in USD thousands): December 31, 2022 2021 2020 Funded Unfunded Total Funded Unfunded Total Funded Unfunded Total Service cost $ (1,759) $ (90) $ (1,849) $ (1,054) $ (80) $ (1,134) $ (1,547) $ (49) $ (1,596) Interest cost (154) (2) (156) (49) (1) (50) (6) (1) (7) Total recognized $ (1,913) $ (92) $ (2,005) $ (1,103) $ (81) $ (1,184) $ (1,553) $ (50) $ (1,603) The follow table presents the pension remeasurement recognized in statement other comprehensive loss (in USD thousands): December 31, 2022 2021 2020 Funded Unfunded Total Funded Unfunded Total Funded Unfunded Total Changes in demographic assumptions $ — $ 223 $ 223 $ 1,278 $ — $ 1,278 $ 1,039 $ — $ 1,039 Changes in financial assumptions 2,311 12 2,323 37 13 50 157 (16) 141 Experience adjustments (201) 15 (186) (844) 13 (831) (952) (14) (966) Total actuarial gains (losses) 2,110 250 2,360 471 26 497 244 (30) 214 Return on plan assets (204) — (204) (32) — (32) (45) — (45) Currency translation differences (4) 2 (2) (4) — (4) 13 2 15 Total recognized $ 1,902 $ 252 $ 2,154 $ 435 $ 26 $ 461 $ 212 $ (28) $ 184 The positive impact of changes in demographic assumptions in 2022 was due principally to an increase in the expected employee salaries fro m 1.25% to 3.00%. T his implies that more members are expected to have a higher pensionable amount before pensionable age. The positive impact of changes in demographic assumptions in 2021 was due principally to an increase in the expected employee salaries from 1.00% to 1.25%. This implies that more members are expected to have a higher pensionable amount before pensionable age. The negative experience adjustments in 2022 and 2021 were due largely to the shortfall between the additional defined benefit obligation attributable to new joiners and the assets that they transferred into the plan. Key actuarial assumptions by plan Discount rate In estimating the defined benefit obligation, the discount rates used were, for the Swiss plan, 2.25% and 0.30% and, for the French plan, 3.90% an d 1.20% fo r the years ended December 31, 2022 and 2021 , respectively. Expected rate of salary increase The expected rate of annual salary increase was assumed to be, for the Swiss plan 3.00% and 1.25% and for the French plan 3.00% and 2.50% for the years ended December 31, 2022 and 2021, respectively. Pension plan modified duration The weighted average modified duration of the Swiss plan is 13.2 years and 15.9 years and of the French plan 16.0 years and 25.9 years for the years ended December 31, 2022 and 2021 , respectively. Interest rates For the Swiss plan, the interest on old age accounts is based, for the LPP account, on the LPP interest rate, w hich was 2.25% and 1.00% and, for the extra mandatory part, is equivalent to the discount rate, which was 2.25% and 0.30% for the ye ars ended December 31, 2022 and 2021 , respectively. Inflation For the Swiss plan, the expected annual rate of inflation is based on the inflation forecast of the Swiss National Bank and was assumed to be 1.50% and 0.75% for the years ended December 31, 2022 and 2021 , respectively. Mortality tables Assumptions regarding future mortality experience are set based on actuarial advice provided in accordance with published statistics and experience and are based on the mortality generational tables BGV 2020 (Swiss) and TH/TF 00-02 (French). For the Swiss plan, the average life expectancy in years after retirement of a pensioner retiring at age 65 (male) and 64 (female) on the balance sheet date is, respectively, 22.70 and 22.57 and 22.48 and 24.37, for the years ended December 31, 2022 and 2021 , respectively. Sensitivity analysis The following tables demonstrate the sensitivity of the defined benefit obligations to changes in the discount rate, expected rates of salary increase, interest credited on savings accounts, inflation and life expectancy at retirement age. The table below presents the sensitivity analysis for the funded plans (in USD thousands): 2022 2021 Discount rates Increase of 25 basis points (426) (576) Decrease of 25 basis points 467 635 Expected rates of salary increases Increase of 25 basis points 110 122 Decrease of 25 basis points (107) (120) Interest rate Increase of 25 basis points 150 189 Decrease of 25 basis points (146) (185) Inflation Increase of 25 basis points 102 121 Decrease of 25 basis points (99) (118) Life expectancy Increase of 1 year 71 145 Decrease of 1 year (71) (145) The table below presents the sensitivity analysis for the unfunded plans (in USD thousands): 2022 2021 Discount rates Increase of 50 basis points (2) (26) Decrease of 50 basis points 2 30 Expected rates of salary increases Increase of 50 basis points 3 30 Decrease of 50 basis points (2) (26) The above sensitivity analyses are based on a change in an assumption while holding all other assumptions constant. In practice, this is unlikely to occur, and changes in some of the assumptions may be correlated. When calculating the sensitivity of the defined benefit obligation to significant actuarial assumptions the same method (present value of the defined benefit obligation calculated with the projected unit credit method at the end of the reporting period) has been applied as when calculating the pension liability recognized within the balance sheet. The methods and types of assumptions used in preparing the sensitivity analysis did not change compared to the prior period. Future employer contributions Expected employer contributions to the Swiss defined benefit pension plan for the year ending December 31, 2023 amount to $1.5 million. Defined contribution plans US pension plan The Company has a multiple employer 401(k) defined contribution plan in the USA. The expense recognized in respect of the defined contribution plan in the USA was $0.4 million and less than $0.2 million and for the years ended December 31, 2022 and 2021, respectively.

Share-based compensation

Share-based compensation	12 Months Ended
	Dec. 31, 2022
Disclosure of terms and conditions of share-based payment arrangement [abstract]
Share-based compensation	Share-based compensation Significant accounting estimates and judgements Share-based Compensation For the years ended December 31, 2022 and 2021, we granted share options under one plan - the SOPHiA GENETICS 2021 Equity Incentive Plan (the “2021 Equity Incentive Plan” or the “2021 EIP”). Under this plan, directors may offer options to directors, employees and advisors. The exercise price of the share options is set at the time they are granted. Options, once vested, can be exchanged for an equal number of ordinary shares. Measuring the cost of share options The fair value of the options under all plans are measured at each grant date using an adjusted form of the Black-Scholes option pricing model, taking into account the terms and conditions upon which the options were granted. For options up to September 2020, the fair value at grant date is independently determined using an adjusted form of the Black-Scholes option pricing model that takes into account the strike price, the fair value of the share at grant date, the expected life of the award, the expected price volatility of the underlying share, the risk-free interest rate for the term of the award and the expected dividend yield. For options granted on and subsequent to September 2020 until July 22, 2021, the fair value at grant date is based on a probability-weighted expected returns method that takes account of both the value derived by using an adjusted form of the Black-Scholes option pricing model, as described above, and a discounted estimate of the price that might be achieved in a future transaction. For options granted on and subsequent to July 22, 2021, the fair value at grant date is determined by using the Black-Scholes option pricing model. The Company has used an independent valuation firm to assist in calculating the fair value of the award grants per participant. The key inputs used in the valuation model, for the stock options granted in the years ended December 31, 2022 and 2021, respectively, are outlined below. Stock options were only granted under the 2021 Employee Incentive Plan (“2021 EIP”). No grants have been made under the 2019 Incentive Share Option Plan (“2019 ISOP”) since 2021 and the SOPHiA GENETICS Incentive Share Option Plan (“2013 ISOP”) since 2019. Prior to the Company’s IPO, the price of the ordinary shares at grant date, which represents a critical input into this model, has been determined on one of the following two bases: • B y reference to a contemporaneous transaction involving another class of share, using an adjusted form of the Black-Scholes option pricing model as described above, and considering the timing, amount, liquidation preferences and dividend rights of issues of other classes of shares. • On the basis of discounted cash flow forecasts, where there was no contemporaneous or closely contemporaneous transaction in another class of share and the time interval was too large to permit an assumption that there had been no significant change in the Company’s equity value. Subsequent to the IPO, the price of the ordinary shares at grant date, which represents a critical input into this model, has been determined on the most recent close price of the Company’s stock price on the date of grant. Accounting policies The Company has three share option plans for directors, employees, and advisors which are accounted for as equity-settled share-based compensation plans. The fair value of options granted under these plans is recognized as an employee benefits expense, with a corresponding increase in equity. The total amount to be expensed is determined by reference to the fair value of the options granted: • including any market performance conditions (e.g., the entity’s share price); • excluding the impact of any service and non-market performance vesting conditions (e.g., profitability, sales growth; targets and remaining an employee of the entity over a specified time period), and; • including the impact of any non-vesting conditions (e.g., the requirement for employees to save or hold shares for a specific period of time). The total expense is recognized over the vesting period, which is the period over which all of the specified vesting conditions are to be satisfied. At the end of each period, the entity revises its estimates of the number of options that are expected to vest based on the non-market vesting and service conditions. It recognizes the impact of the revision to original estimates, if any, in income, with a corresponding adjustment to equity. Estimating fair value for share-based payment transactions requires determination of the most appropriate valuation model, which depends on the terms and conditions of the grant. This estimate also requires determination of the most appropriate inputs to the valuation model including the share price, or the fair value of a share, the expected life of the share option, the volatility of the share price, the risk-free interest rate, the dividend yield, and making certain assumptions about the inputs. The assumptions used for estimating fair value for share-based payment transactions are disclosed below. The volatility used in the estimation of fair value is calculated utilizing a mix of the Company’s own share price volatility and the volatility of the share prices of a set list of publicly traded peer companies based on a defined proportion. Share price volatility is calculated for each tranche of share options on a historical basis over a period of time equal to the average life of the share options granted in each tranche. In the event that a company used in the volatility calculation has not been publicly traded for the requisite amount of time, the entirety of its trading history was used. If the shares are not listed, estimating their fair value also requires determination of the most appropriate valuation model, such as: • By reference to a contemporaneous transaction involving another class of share, using an adjusted form of an option pricing model above, and considering the timing, amount, liquidation preferences and dividend rights of issues of other classes of shares; • On the basis of discounted cash flow forecasts, where there was no contemporaneous or closely contemporaneous transaction in another class of share and the time interval was too large to permit an assumption that there had been no significant change in the Company’s equity value; • Share based compensation expense is measured at the fair value of the options at the grant date and recognized over the vesting period. Share based compensation expense is presented in the statement of income/loss and allocated to the various expense categories based on the functions of the employees to whom the options are granted (e.g., research and development, selling and marketing, general & administrative). The calculation of the cost of the Company’s share option grants and of the fair value of the ordinary shares at the grant date requires the selection of an appropriate valuation model and is based on key assumptions that leave considerable scope for judgement. Recognizing the cost of share options At each reporting date, the Company takes a charge for the vested options granted and for partially earned but non-vested portions of options granted. This results in a front-loaded charge to the statement of loss. Prior to the IPO, at each reporting date, the Company reappraised its estimate of the likelihood and date of a future transaction that would cause all options which would vest six months from the transaction date to vest and, if necessary, accelerated the recognition of the unrecognized cost in the statements of loss. The Company accounts for these plans as equity-settled transactions. The charge to the statements of loss therefore results in a corresponding credit being booked to “Other reserves” within equity. The plans The Company has three share option plans: the 2013 ISOP (launched in September 2013), the 2019 ISOP (launched March 2019), and the 2021 EIP (launched June 2021). Under these plans, directors may offer options to directors, employees and advisors. The exercise price of the share options is set at the time they are granted. Options, once vested, can be exchanged for an equal number of ordinary shares. Under the 2021 EIP, the Company can grant restricted stock units (“RSUs”) which represent the right to receive ordinary shares upon meeting specific vesting requirements. RSUs are able to be granted to directors, executives, and employees. The options have a life of ten years. Options under the 2013 ISOP vest 50% on the second anniversary of the grant date and a further 50% on the third anniversary of the grant date. Options under the 2019 ISOP vest 25% on each anniversary of the grant date over four years. The options under the 2021 EIP vest 25% on the first anniversary of the grant date and the remaining 75% vesting ratably on a monthly basis over the remaining three years. Refer to Restricted Stock Units below for the vesting schedules of the RSUs under the 2021 EIP. On April 22, 2021, the Board amended the 2019 ISOP to the effect that, in the event of a successful IPO or public listing of the Company’s shares, only those unvested options that otherwise would vest within six months following the effective date of the IPO or such public listing should become fully vested immediately as of such date (accelerated vesting). The remaining unvested options (i.e., unvested options that would only vest after the six-month period following the effective date of the IPO or public listing) would not be subject to accelerated vesting and, subject to certain conditions, would vest on the basis of the original vesting schedule. Additionally, the Board instituted a black-out period, irrespective of a successful IPO or public listing of the Company, in which no options could be exercised from May 1, 2021 to January 19, 2022, and to accelerate the vesting of options that would otherwise vest during that period. The Company assessed the amendment to the 2019 ISOP and concluded it resulted in a modification. As such, the Company assessed the valuation of the options immediately prior to and subsequently after the modification. As a result of the modification, the Company incurred an additional expense of $0.2 million year ended December 31, 2021. 2013 ISOP Activity for the year ended December 31, 2022, under the 2013 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 859,540 $ 2.75 5.08 Exercised (193,560) 2.44 — Forfeited (8,000) 3.19 — Outstanding as of December 31, 2022 657,980 $ 2.92 4.24 Exercisable as of December 31, 2022 657,980 $ 2.92 4.24 Activity for the year ended December 31, 2021, under the 2013 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 1,751,560 $ 3.10 6.39 Exercised (892,020) 3.00 — Outstanding as of December 31, 2021 859,540 $ 2.75 5.08 Exercisable as of December 31, 2021 849,540 $ 2.75 5.06 Options outstanding as of December 31, 2021, under the 2013 ISOP expire between 2023 and 2029. The weighted average share price at the date of exercise were $7.41 and $13.84 for the years ended December 31, 2022 and 2021, respectively. 2019 ISOP Activity for the year ended December 31, 2022, under the 2019 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 2,812,500 $ 5.83 8.61 Exercised (47,000) 7.25 — Forfeited (135,984) 5.15 — Outstanding as of December 31, 2022 2,629,516 $ 4.96 7.21 Exercisable as of December 31, 2022 1,476,744 $ 4.41 6.56 Activity for the year ended December 31, 2021, under the 2019 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 1,972,500 $ 4.22 9.11 Granted 1,369,000 8.75 9.12 Forfeited (149,750) 5.54 — Exercised (379,250) 4.00 — Outstanding as of January 1, 2021 2,812,500 $ 5.83 8.61 Exercisable as of December 31, 2021 455,500 $ 1.37 7.85 The valuation inputs for the 2019 ISOP grants were as follows: Twelve months ended December 31, 2022 2021 2020 Share price at grant date (in USD) N/A $5.59 $4.36 - $4.87 Expected life of share options (years) N/A 6.05 - 6.19 5.67 - 6.43 Expected volatility N/A 41.26% - 41.45% 39.84% - 43.56% Risk free interest rate N/A (0.63)% - (0.48)% (0.80)% - (0.53)% Dividend yield (%) N/A —% —% The weighted average share price at the date of exercise were $6.19 and $13.84 for the years ended December 31, 2022 and 2021, respectively. 2021 EIP Activity for the year ended December 31, 2022, under the 2021 EIP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 1,576,069 $ 17.96 9.57 Granted 1,336,284 6.03 — Forfeited (288,056) 14.00 — Outstanding as of December 31, 2022 2,624,297 $ 12.32 8.88 Exercisable as of December 31, 2022 528,693 17.98 8.04 No options under the EIP 2021 were exercised for the years ended December 31, 2022 and 2021, respectively. Activity for the year ended December 31, 2021, under the 2021 EIP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 — $ — — Granted 1,595,314 17.96 9.57 Forfeited (19,245) 18.00 — Outstanding as of January 1, 2021 1,576,069 $ 17.96 9.57 Exercisable as of December 31, 2021 — $ — — Options outstanding as of December 31, 2022, under the 2021 EIP expire between 2031 and 2032. The valuation inputs for the 2021 EIP grants were as follows:: Year Ended December 31, 2022 2021 Share price at grant date (in USD) $2.06 - $8.36 $16.81 - $18.00 Expected life of share options (years) 5.50 - 7.00 5.50 - 7.00 Expected volatility 62.65% - 69.43% 41.65% - 59.77% Risk free interest rate 2.42% - 4.00% 0.87% - 1.36% Dividend yield (%) —% —% Share options outstanding at the year ended December 31, 2022 The weighted average fair value of options granted during the years ended December 31, 2022 and 2021, respectively (in USD): 2022 2021 2019 ISOP N/A $ 2.12 2021 EIP $ 3.62 $ 9.87 Movements in the share-based compensation reserve were as follows (in USD thousands): Total January 1, 2021 $ 2,948 Movement in the period 8,514 December 31, 2021 11,462 Movement in the period 13,613 December 31, 2022 $ 25,075 Share-based compensation expense by financial statement caption for all stock awards consists of the following (in USD thousands): Year ended December 31, 2022 2021 2020 Research and development $ 2,245 $ 784 $ 149 Sales and marketing 1,462 1,227 212 General and administrative 9,906 6,503 998 Total $ 13,613 $ 8,514 $ 1,359 Commitment to grant options to CEO on IPO In addition to the options granted, as set out above, the Board committed on November 29, 2018 to award to the CEO 300,000 share options, if the Company completed an IPO that valued the Company at a minimum of $1.0 billion. No other terms and conditions were specified, although it was assumed that the strike price would be equal to the IPO share price and that there could be further vesting conditions in terms of service beyond the IPO date. On March 25, 2021, the Board formally clarified the conditions of this commitment to grant options to the CEO upon an IPO. Specifically, the Board set the grant date as November 29, 2018, set the strike price at $3.33 (CHF 3.15), confirmed the condition of an IPO that valued the Company at a minimum of $1 billion and set the life of the option at five years. On the basis of these terms, the award was valued as of that date at $0.3 million. This value will not be updated at a later date as all terms and conditions of the award were approved. The expense of $0.3 million will be recognized when it becomes probable that an IPO that values the Company at a minimum of $1.0 billion will occur before November 29, 2023. The Company recognized $0.3 million for the year ended December 31, 2021, related to the Company’s IPO in July 2021. Restricted Stock Units As part of the 2021 EIP, the Company initiated granting of RSUs, which represent the right to receive shares of ordinary shares upon meeting specified vesting requirements. In the year ended December 31, 2022, the Company issued 1,776,832 RSU under the 2021 plan. Under the terms of the 2021 plan, 1,396,366 of the RSUs issued are subject to a four-year vesting schedule with 25% vesting on the first anniversary of the grant date and the remaining 75% ratably on a monthly basis over the remaining three years, and the remaining 380,466 of the RSUs issued to non-executive members of the Company’s board of directors are subject to a vesting period set to be completed upon the Company’s 2023 Annual General Meeting. The activity for the year ended December 31, 2022 was as follows: Number of RSUs Weighted-average grant date fair value per share Unvested as of January 1, 2022 287,575 $ 17.97 Granted 1,776,832 4.30 Vested (133,056) 17.99 Forfeited (65,918) 10.72 Unvested as of December 31, 2022 1,865,433 $ 5.20 The activity for the year ended December 31, 2021 was as follows: Number of RSUs Weighted-average grant date fair value per share Unvested as of January 1, 2021 — $ — Granted 290,407 17.97 Forfeited (2,832) 18.00 Unvested as of December 31, 2021 287,575 $ 17.97

Borrowings

Borrowings	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about borrowings [abstract]
Borrowings	Borrowings Credit Suisse loan On April 1, 2021, the Company entered into a credit agreement (the “Credit Facility”) with Credit Suisse that provides for maximum borrowings of up to $3.3 million (EUR 2.7 million). Borrowings under the Credit Facility accrue interest at 3.95% per annum and are repayable in installations over 36 months. Borrowings under the Credit Facility can only be used to finance laboratory automation equipment for next generation sequencing (“NGS”) purposes. As of the date of these consolidated financial statements, the Company had no borrowings outstanding under the Credit Facility. Revolving credit facility On June 21, 2022 the Company entered into a credit agreement (“the Credit Facility”) with Credit Suisse Group AG for up to CHF 5.0 million. Borrowings under the credit facility will bear interest at a rate to be established between the Company and Credit Suisse at the time of each draw down. Borrowings under the Credit Facility have no restrictions related to its use. As of December 31, 2022, the Company had no borrowings outstanding under the Credit Facility. During the period since January 1, 2020, the Company has not been subject to any externally imposed capital requirements.

TriplePoint success fee

TriplePoint success fee	12 Months Ended
	Dec. 31, 2022
Triple Point Success Fee [Abstract]
TriplePoint success fee	TriplePoint success fee Significant accounting estimates and judgements The derivative included in the table below presents the change in fair value of a success fee payable to TriplePoint Capital LLC (“TriplePoint”), the providers of a loan repaid in 2020 (see Note 24 - “Borrowings”) upon an initial public offering of the Company or a sale of the Company. The amount of the success fee will be computed as the excess of the value per share realized in such a transaction over a strike price of $3.65 (CHF 3.65) multiplied by 6.5% of the committed loan facility of EUR 10 million translated to CHF at a rate of 1.16 and divided by the strike price of $3.65 (CHF 3.65). Accounting Policies In the third quarter of 2021, the Company paid the success fee payable to TriplePoint, which became due upon an IPO of the Company or a sale of the Company. The Company’s IPO in July 2021 triggered the success fee to become due. The approach used to determine the fair value of the derivative was based on a Monte Carlo simulation and accounted for as embedded derivative. The following table presents the loss recognized by the Company on the derivative associated with the TriplePoint loan (in USD thousands): 2022 2021 2020 As of January 1 $ — $ 1,024 $ 557 Loss on derivative — 1,444 467 As of December 31 $ — $ 2,468 $ 1,024 As the derivative became payable in September 2021, the Company did not have any assumptions as of December 31, 2021 as the actual value was determined. As the Company had no derivative in the 2022 fiscal year, the Company did not have any assumptions as of December 31, 2022. The Company recognized no loss and a loss of $1.4 million to finance income (expense) on the Consolidated Statement of Loss for the year ended December 31, 2022 and 2021, respectively. In September 2021, the Company successfully negotiated a $0.4 million reduction of the success fee to $2.5 million from $2.9 million. The reduction resulted in a $0.4 million gain in Finance expense, net. The Company paid the $2.5 million success fee in September 2021.

Initial Public Offerings

Initial Public Offerings	12 Months Ended
	Dec. 31, 2022
Disclosure Of Initial Public Offerings [Abstract]
Initial Public Offerings	Initial Public Offerings On July 27, 2021, the Company completed its IPO in the United States on the Nasdaq Global Market (“Nasdaq”) under the trading ticker symbol “SOPH”. Trading on the Nasdaq commenced at market open on July 23, 2021. The Company completed the IPO of 13,000,000 common shares, at the IPO price of $18.00 per share, par value $0.05 (CHF 0.05). The IPO resulted in gross proceeds of $234.0 million. The Company incurred an estimated $22.3 million in issuance costs associated with the IPO, resulting in net proceeds of $211.7 million. Concurrent with the IPO, the Company closed a private placement, in which it sold 1,111,111 ordinary shares to an affiliate of GE Healthcare. Gross proceeds from the private placement, before deducting estimated expenses payable, were $20 million. The Company incurred $0.4 million of issuance costs, resulting in net proceeds of $19.6 million. On August 25, 2021, the underwriters of the IPO elected to exercise in part their option to purchase an additional 519,493 ordinary shares (“greenshoe”) at the IPO price of $18.00 per share. The greenshoe resulted in additional gross proceeds of $9.4 million. The Company incurred an additional $0.9 million of additional issuance costs, resulting in net proceeds of $8.5 million. With the addition of the underwriters’ option to purchase additional shares, the total number of shares sold in the Company’s IPO increased to 13,519,493 shares for aggregate gross proceeds, before deducting underwriting discounts and commissions and estimated fees and offering expenses, of $243.4 million. As a result of the IPO, the Company paid a success fee related to the TriplePoint loan (Note 25 – TriplePoint success fee). Immediately prior to the completion of the Company’s IPO and current with the private placement, the Company’s outstanding preferred shares converted on a one-to-one basis into ordinary shares.

Share capital issuance

Share capital issuance	12 Months Ended
	Dec. 31, 2022
Disclosure of classes of share capital [abstract]
Share capital issuance	Share capital issuance On June 25, 2020, the Company issued 5,664,480 preferred F shares at a price per share of $11.53 per share, which resulted in gross proceeds of $65.3 million and, after deduction of transaction costs of $0.7 million, in net proceeds of $64.6 million. On September 23, 2020, the Company issued 3,652,460 preferred F shares at a price per share of $11.89 per share, which resulted in gross proceeds of $43.4 and, after deduction of transaction costs of $0.4 million, in net proceeds of $43.0 million. Pursuant to the Articles of Association, in the event of certain defined liquidation events, holders of the preferred F shares are entitled to receive the higher of (i) a pro rata share of the liquidation proceeds and (ii) one time the subscription price paid for the preferred F shares. Pursuant to the Articles of Association, in the event of certain defined liquidation events, and subject to the liquidation preference of the preferred F shares, holders of the preferred E shares are entitled to receive the higher of (i) a pro rata share of the liquidation proceeds and (ii) one time the subscription price paid for the preferred E shares. Pursuant to the Articles of Association, in the event of certain defined liquidation events, and subject to the liquidation preferences of the preferred F shares and of the preferred E shares, holders of the preferred D shares are entitled to receive the higher of (i) a pro rata share of the liquidation proceeds and (ii) one time the subscription price paid for the preferred D shares. On June 30, 2021, the Company performed a one-to-twenty share split and converted all preferred shares to ordinary shares. Refer to Note 1 – “Company information and operations - Share split.” On July 22, 2021 as part of the Company IPO, the Company converted all preferred shares to ordinary shares. Refer to Note 1- “Company information and operations - Initial public offering.” At the next ordinary Annual General Meeting, the Board of Directors will not propose any dividend in respect of the year ended December 31, 2022.

Related parties

Related parties	12 Months Ended
	Dec. 31, 2022
Disclosure of transactions between related parties [abstract]
Related parties	Related parties Related parties comprise the Company’s executive officers and directors, including their affiliates, and any person that directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control, with the Company. Key management personnel comprised of six Executive Officers and Directors and seven Non-Executive Directors for the year ended December 31, 2022. Key management personnel comprised of six Executive Officers and Directors and six Non-Executive Directors for the year ended December 31, 2021. Key management personnel comprised of four Executive Officers and Directors and four Non-Executive Directors for the year ended December 31, 2020. Compensation for key management and non-executive directors recognized during the year comprised (in USD thousands): December 31, 2022 2021 2020 Salaries and other short-term employee benefits $ 3,368 $ 2,761 $ 1,155 Pension costs 196 117 70 Share-based compensation expense 8,936 6,906 1,065 Other compensation 414 44 146 Total $ 12,914 $ 9,828 $ 2,436 On March 25, 2021, the Board changed the strike price on 127,000 options granted to the CEO in September 2018 from $4.22 (CHF 4.00) to $3.33 (CHF 3.15). The Company calculated the fair value of these options using the same approach as that used to value share options granted since September 2020, which resulted in an increase of $0.1 million. This incremental cost is now being recognized as an expense over the period from March 25, 2021, until the end of the vesting period of the original grant. On March 25, 2021, the Board also clarified the terms of an award made to the CEO on November 29, 2018. This award is conditional on the achievement by November 29, 2023, of a successful IPO that values the Company at a minimum of $1.0 billion. Further details of the award and its accounting treatment are set out in Note 23 - “Share-based compensation”. Related parties participated in the sale of Series F preferred shares during 2020 to the following extent: Name of shareholder Number of preferred shares purchased Alychlo NV 233,580 Generation IM Sustainable Fund III, L.P 389,300 Total 622,880 Three members of key management participated in share issuances in 2020 acquiring a total of 65,920 shares. Share data have been revised to give effect to the share split explained in Note 1 - “Company information and operations.”

Commitments and contingencies

Commitments and contingencies	12 Months Ended
	Dec. 31, 2022
Disclosure of contingent liabilities in business combination [abstract]
Commitments and contingencies	Commitments and contingencies Commitments The Company has commitments for future lease payments under short-term leases not recognized in the balance sheet amounting as of December 31, 2022 and 2021 of $0.2 million, and $0.3 million, respectively. The Company entered into an agreement with Microsoft Corporation as of November 1, 2022. As part of the agreement, the Company has commitments of approximately $69.4 million in computational and hosting-related costs through October 31, 2027. Contingencies As of December 31, 2022 and 2021 the Company had no contingent assets or liabilities.

Financial instruments and risks

Financial instruments and risks	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about financial instruments [abstract]
Financial instruments and risks	Financial instruments and risks A financial instrument is any contract that gives rise to a financial asset of one entity and a financial liability or equity instrument of another entity. The Company holds the following financial instruments (in USD thousands): December 31, 2022 2021 Financial assets at amortized cost Cash and cash equivalents $ 161,305 $ 192,962 Term deposits 17,307 72,357 Accounts receivable 6,649 5,621 Other financial non-current assets 965 1,405 Total financial assets at amortized cost $ 186,226 $ 272,345 Financial assets at fair value through statement of loss Total financial assets $ 186,226 $ 272,345 Financial liabilities at amortized cost Accounts payable 6,181 6,737 Accrued expenses 14,505 15,972 Lease liabilities 16,743 13,059 Total financial liabilities at amortized cost 37,429 35,768 Financial liabilities at fair value through statement of loss Total financial liabilities $ 37,429 $ 35,768 The Company’s exposure to various risks associated with the financial instruments is discussed in below in “Financial risk management.” The maximum exposure to credit risk at the end of the reporting period is the carrying amount of each class of financial assets mentioned above. See Note 13 - “Accounts receivable” for expected credit loss provisions on accounts receivable. Fair value measurement As of December 31, 2022 and 2021 , the carrying amount was a reasonable approximation of fair value for the following financial assets and liabilities: Financial assets • Cash and cash equivalents • Term deposits • Accounts receivable • Other non-current assets—lease deposits and lease receivable Financial liabilities • Accounts payable • Accrued liabilities • Lease liabilities • Derivatives • Borrowings Fair value measurement methodology The Company measures financial instruments at fair value at each balance sheet date. Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The fair value measurement is based on the presumption that the transaction to sell the asset or transfer the liability takes place either in the principal market for the asset or liability or, in the absence of a principal market, in the most advantageous market for the asset or liability. The fair value of an asset or a liability is measured using the assumptions that market participants would use when pricing the asset or liability, assuming that market participants act in their economic best interest. A fair value measurement of a non-financial asset takes into account a market participant’s ability to generate economic benefits by using the or by selling it to another market participant. The Company uses valuation techniques to measure fair value maximizing the use of relevant observable inputs and minimizing the use of unobservable inputs. All assets and liabilities for which fair value is measured or disclosed in the consolidated financial statements are categorized within the fair value hierarchy, described as follows, based on the lowest level input that is significant to the fair value measurement as a whole: Level 1—Quoted (unadjusted) market prices in active markets for identical assets or liabilities. Level 2—Valuation techniques for which the lowest level input that is significant to the fair value measurement is directly or indirectly observable. Level 3—Valuation techniques for which the lowest level input that is significant to the fair value measurement is unobservable. For assets and liabilities that are recognized in the consolidated financial statements at fair value on a recurring basis, the Company determines whether transfers have occurred between levels in the hierarchy by re-assessing categorization (based on the lowest level input that is significant to the fair value measurement as a whole) at the end of each reporting period. Management determines the policies and procedures for both recurring fair value measurement and for non-recurring measurement with the involvement of experts and external consultants when needed. Derivatives, which were extinguished in July 2021, included within other current liabilities (see Note 21 - “Other non-current liabilities”), comprised of a success fee payable upon an initial public offering or a sale of the Company. This option was carried at fair value. The fair value of the option had been estimated using a Monte Carlo simulation. The basis of measurement is considered to be level 3 owing to the use of unobservable inputs, including the fair value of the Company’s own shares. In 2022 and 2021 there were no significant changes in the business or economic circumstances that affect the fair value of the Company’s financial assets and financial liabilities. There were also no transfers between categories. Financial risk management Financial risks Senior management regularly review the Company’s cash forecast and related risks. They also perform the risk assessment, define any necessary measures and ensure the monitoring of the internal control system. The Company’s principal financial liabilities include accounts payable, lease liabilities and borrowings. The Company’s principal financial assets include cash and cash equivalents, term deposits and short-term investments and accounts receivable. In the course of its business, the Company is exposed to a number of financial risks including credit and counterparty risk, funding and liquidity risk and market risk (i.e. foreign currency risk and interest rate risk). This note presents the Company’s objectives, policies, and processes for managing these risks. Credit and counterparty risk management Credit risk is the risk that a counterparty will not meet its obligations under a financial instrument or customer contract, leading to a financial loss. The Company is exposed to credit risk from its operating activities, primarily accounts receivable. Concentration risk arises when a number of counterparties are engaged in similar business activities, or activities in the same geographical region, or have economic features that would cause their ability to meet contractual obligations to be similarly affected by changes in economic, political or other conditions. The Company’s policy with regard to assessing and providing for expected credit losses on accounts receivable is set out in Note 13 - “Accounts receivable.” Credit risk from balances with banks and financial institutions is managed by the Company’s treasury department in accordance with the Company’s policy. Financial transactions are predominantly entered into with investment grade financial institutions and in principle the Company requires a minimum long-term rating of A3/A- for its cash investments and term deposits. The Company may deviate from this requirement from time to time for operational reasons. The highest exposure to a single financial counterparty within cash and cash equivalents and term deposits and short-term investments amounted to $57.3 million and $78.2 million as of December 31, 2022 and 2021 , respectively. Other non-current financial assets include cash deposits for leases. Funding and liquidity risk management Funding and liquidity risk is the risk that a company may encounter difficulties in meeting its obligations associated with financial liabilities that are settled by delivering cash or other financial assets. Such risk may result from inadequate market depth or disruption or refinancing problems. The Company views equity funding as its primary source of liquidity only partly complemented with revenue generated from the sale of the platform, applications, products, and services and some borrowings. The Company has no outstanding borrowing facilities. Short term liquidity is managed based on projected cash flows. As of December 31, 2022 and 2021 , the Company’s liquidity consisted of $161.3 million and $193.0 million in cash and cash equivalents, respectively. On the basis of the current operating performance and liquidity position, management believes that the available cash balances will be sufficient for operating activities, working capital, interest, capital expenditures and scheduled debt repayments for the next 12 months. The table below summarizes the maturity profile of the Company’s financial liabilities based on contractual undiscounted cash flows (in USD thousands): Net carrying amount Within 1 year Between 1 and 5 years After 5 years Total December 31, 2022 Lease liabilities $ 16,743 $ 2,950 $ 8,862 $ 6,421 $ 18,233 Accounts payable 6,181 6,181 — — 6,181 Accrued expenses 14,505 14,505 — — 14,505 Total contractual liabilities $ 37,429 $ 23,636 $ 8,862 $ 6,421 $ 38,919 December 31, 2021 Lease liabilities $ 13,059 $ 2,018 $ 8,467 $ 4,075 $ 14,560 Accounts payable 6,737 6,737 — — 6,737 Accrued expenses 15,972 15,972 — — 15,972 Total contractual liabilities $ 35,768 $ 24,727 $ 8,467 $ 4,075 $ 37,269 Market risk Market risk includes currency risk and interest rate risk. Currency risk Foreign currency risk is the risk that the fair value or future cash flows of an exposure will fluctuate because of changes in foreign exchange rates. The significant exchange rates that have been applied to these consolidated financial statements are listed below: December 31, For the twelve months ended December 31, 2022 2021 2022 2021 2020 Currency Spot rate Spot rate Average rate Average rate Average rate USD/CHF 0.92447 0.91210 0.95500 0.91437 0.94703 USD/EUR 0.93414 0.88290 0.95146 0.84579 0.88423 USD/GBP 0.82761 0.74190 0.81177 0.72707 0.78132 USD/BRL 5.28600 5.57130 5.16678 5.39288 5.06281 The sensitivity of the Company’s income to possible changes in foreign exchange rates is measured at the local entity level as it depends on the functional currency of each entity. As of December 31, 2022 and 2021 , the Company was exposed principally to movements in four cross currency pairs. The sensitivity of the Company’s loss before tax to such changes was as follows (in USD thousands): December 31, 2022 2021 2020 Increase / (decrease) in USD/CHF exchange rate by 10% 6,614 / (6,614) 19,499 / (19,499) 1,453 / 1,453 Increase / (decrease) in EUR/CHF exchange rate by 10% (94) / 94 648 / (648) 836 / (836) Increase / (decrease) in GBP/CHF exchange rate by 10% (83) / 83 (18) / 18 351 / (351)) Increase / (decrease) in USD/EUR exchange rate by 10% 503 / (503) 726 / (726) 155 / (155) The Company’s exposure to foreign currency changes for all other currencies is not material. The significant increase/decrease between USD/CHF resulted from the Company’s IPO, which occurred in USD. The Company does not use derivative financial instruments to hedge exposures and under no circumstances may enter into derivative instruments for speculative purposes. The sensitivity of the Company’s reported equity or net assets to possible changes in foreign exchange rates is measured at the consolidated level as it depends on the presentation currency selected for the consolidated financial statements. Such effects are reported not in income but in the currency translation account within other reserves. As of December 31, 2022 and 2021 the sensitivity of the Company’s equity to such changes, measured against the USD, was as follows (in USD thousands): December 31, 2022 2021 Increase / (decrease) in USD/CHF exchange rate by 10% 14,198 / (14,198) 54 / (54) Increase / (decrease) in USD/EUR exchange rate by 10% (44) / 44 (89) / 89 Increase / (decrease) in USD/GBP exchange rate by 10% 50 / (50) (27) / 27 Increase / (decrease) in USD/BRL exchange rate by 10% 133 / (133) 77 / (77) Interest rate risk The Company’s cash and cash equivalents and term deposits are subject to market risk associated with interest rate fluctuations. Fixed rate securities may have their market value adversely affected due to a rise in interest rates. The Company conclude fluctuations in the interest rate did not have a material impact on our cash equivalents and term deposit balances.

Capital management

Capital management	12 Months Ended
	Dec. 31, 2022
Capital commitments [abstract]
Capital management	Capital management The Company considers equity as equivalent to the IFRS equity on the balance sheet (including share capital, share premium and all other equity reserves attributable to the owners of the Company). The primary objective of the Company’s capital management is to maximize shareholder value. The Board regularly reviews its shareholders’ return strategy. For the foreseeable future, the Board will maintain a capital structure that supports the Company’s strategic objectives through managing funding and liquidity risks and optimizing shareholder return. As of December 31, 2022 and 2021 , the Company’s cash and cash equivalents amounted to $161.3 million and $193.0 million, respectively. The Company’s government-issued COVID loans have below-market interest rates, of which all have since been repaid as of December 31, 2021. The Board of Directors believes that the Company has sufficient financial resources to meet all of its obligations for at least the next twelve months. Moreover, the Company is not exposed to liquidity risk through requests for early repayment of loans.

Events after the reporting date

Events after the reporting date	12 Months Ended
	Dec. 31, 2022
Disclosure Of Events After Reporting Period [Abstract]
Events after the reporting date	Events after the reporting dateThe Company has evaluated, for potential recognition and disclosure, events that occurred prior to the date at which the consolidated financial statements were available to be authorized for issuance. There were no material subsequent events.

Significant accounting polici_2

Significant accounting policies (Policies)	12 Months Ended
	Dec. 31, 2022
Summary Of Significant Accounting Policies [Abstract]
Basis of preparation	Basis of preparation Compliance with International Financial Reporting Standards The consolidated financial statements of the Company have been prepared in accordance with International Financial Reporting Standards (“IFRS”) and interpretations issued by the IFRS Interpretations Committee (“IFRS IC”) applicable to companies reporting under IFRS. The consolidated financial statements comply with IFRS as issued by the International Accounting Standards Board (“IASB”).
Basis of consolidation	Basis of consolidation A subsidiary is an entity over which the Company has control. The Company controls an entity when it has the power to direct its activities and has rights to its variable returns. Subsidiaries are fully consolidated from the date on which control is transferred to the Company and deconsolidated from the date that control ceases. During the consolidation process intercompany transactions, balances, and unrealized gains on transactions between companies are eliminated. Unrealized losses are also eliminated unless there is evidence of an impairment of the transferred asset. In order to ensure consistency with the accounting policies of the Company, the accounting policies of subsidiaries have been changed where necessary.
Foreign currency translation	Foreign currency translation Items included in the consolidated financial statements of each of the Company’s entities are measured using the currency of the primary economic environment in which the entity operates (“functional currency”). In individual entities, transactions in foreign currencies are translated as of transaction date. Monetary assets and liabilities in foreign currencies are translated at month end rates. The Company’s reporting currency of the Company’s consolidated financial statements is the U.S. dollar (“USD”). Assets and liabilities denominated in foreign currencies are translated at the month-end spot exchange rates, income statement accounts are translated at average rates of exchange for the period presented, and equity is translated at historical exchange rates. On consolidation, assets and liabilities of foreign operations reported in their local functional currencies are translated into USD. Differences arising from the retranslation of opening net assets of foreign operations, together with differences arising from the translation of the net results for the year of foreign operations, are recognized in other comprehensive income under currency retranslations. Gains or losses resulting from foreign currency transactions are included in net income. The Company selected the U.S. dollar as its presentation currency for purposes of its consolidated financial statements instead of the Company’s functional currency, the Swiss franc, because of the global nature of its business, its expectation that an increasing portion of revenues and expenses will be denominated in USD, and its plans to continue to access U.S. capital markets.
Use of estimates	Use of estimates The preparation of consolidated financial statements in conformity with IFRS requires the use of accounting estimates. It also requires management to exercise judgement in applying the Company’s accounting policies. The Company’s significant estimates and judgements included in the preparation of the consolidated financial statements are related to revenue recognition, capitalized internal software development costs, share-based compensation, expected credit loss, goodwill, defined benefit pension liabilities, uncertain tax positions, and derivatives. Disclosed in the corresponding sections within the footnotes are the areas which require a high degree of judgment, significant assumptions, and/or estimates.
Going concern basis	Going concern basisThe consolidated financial statements have been prepared on a going concern basis
Historical cost convention	Historical cost convention The consolidated financial statements have been prepared on a historical cost basis except for certain assets and liabilities, which are carried at fair value.
Accounting policies	Accounting policies The significant accounting policies adopted in the preparation of the consolidated financial statements have been consistently applied, unless otherwise stated.
Provisions and contingencies	Provisions and contingencies Provisions comprise liabilities of uncertain timing or amount. The provisions and liabilities are recognized when the Company has a present legal or constructive obligation as a result of past events, it is probable that an outflow of resources will be required to settle the obligation, and the amount can be reliably estimated. Provisions are not recognized for future operating losses. Provisions are measured at the present value of management’s best estimate of the expenditure required to settle the present obligation at the end of the reporting period, unless the impact of discounting is immaterial. The discount rate used to determine the present value is a pre-tax rate that reflects current market assessments of the time value of money and the risks specific to the liability. The increase in the provision due to the passage of time is recognized as interest expense. Contingent liabilities are possible obligations that arise from past events and whose existence will be confirmed only by the occurrence or non-occurrence of one or more uncertain future events not fully within the control of the Company. The likelihood of occurrence of provisions and contingent liabilities requires use of judgement. Judgement is also required to determine if an outflow of economic resources is probable, or possible but not probable. Where it is probable, a liability is recognized, and further judgement is used to determine the level of the provision. Where it is possible but not probable, further judgement is used to determine if the likelihood is remote, in which case no disclosures are provided; if the likelihood is not remote then judgement is used to determine the contingent liability disclosed.
Financial assets classification	Financial assets classification Upon recognition, financial assets are classified on the basis of how the financial assets are measured: at amortized cost or fair value through income. The classification of financial assets at initial recognition depends on the financial asset’s contractual cash flow characteristics and the Company’s business model for managing them. Except for accounts receivable that do not contain a significant financing component, the Company initially measures a financial asset at its fair value plus, in the case of a financial asset not at fair value through income, transaction costs. Accounts receivable that do not contain a significant financing component are measured at the transaction price. The Company’s business model for managing financial assets is defined by whether cash flows will result from collecting contractual cash flows, selling the financial assets, or both. Financial assets held in order to collect contractual cash flows are measured at amortized cost. Financial assets held both to collect contractual cash flows and for sale are measured at fair value through other comprehensive income/loss. Purchases or sales of financial assets that require delivery of assets within a time frame established by regulation or convention in the marketplace (regular way trades) are recognized on the trade date, i.e., the date that the Company commits to purchase or sell the asset. Financial assets measured at amortized cost Financial assets initially measured at amortized cost are subsequently measured using the effective interest rate (“EIR”) method and are subject to impairment. Gains and losses are recognized in income when the asset is derecognized, modified, or impaired. The Company’s financial assets at amortized cost include cash, term deposits and accounts receivable. Financial assets—derecognition A financial asset (or, where applicable, a part of a financial asset or part of a group of similar financial assets) is primarily derecognized (i.e., removed from the Company’s consolidated balance sheet) when: • the rights to receive cash flows from the asset have expired or; • the Company has transferred its rights to receive cash flows from the asset or has assumed an obligation to pay the received cash flows in full without material delay to a third party under a ‘pass-through’ arrangement; and either; • the Company has transferred substantially all the risks and rewards of the asset, or; • the Company has neither transferred nor retained substantially all the risks and rewards of the asset but has transferred control of the asset. When the Company has transferred its rights to receive cash flows from an asset or has entered into a pass-through arrangement, it evaluates if, and to what extent, it has retained the risks and rewards of ownership. When the Company has neither transferred nor retained substantially all of the risks and rewards of the asset, nor transferred control of the asset, the Company continues to recognize the transferred asset to the extent of its continuing involvement. In that case, the Company also recognizes an associated liability. The transferred asset and the associated liability are measured on a basis that reflects the rights and obligations that the Company has retained. Continuing involvement that takes the form of a guarantee over the transferred asset is measured at the lower of the original carrying amount of the asset and the maximum amount of consideration that the Company could be required to repay. Financial assets—impairment For cash, cash equivalents, and term deposits, the Company invests in assets where it has never incurred and does not expect to incur credit losses.
Financial liabilities classification	Financial liabilities classification Financial liabilities are classified upon initial recognition as financial liabilities measured at fair value through income or at amortized cost. The Company’s financial liabilities include accounts payable and debt (including borrowings and lease liabilities), which are measured at amortized cost, and derivatives, which are measured at fair value through income. Interest-bearing borrowings are initially recognized at fair value less directly attributable costs and subsequently measured at amortized cost using the EIR method. Gains and losses are recognized in income when the liabilities are derecognized as well as through the EIR amortization process. Amortized cost is calculated by taking into account any discount or premium on acquisition and fees or costs that are an integral part of the EIR. The EIR amortization is included as finance costs in the statement of income/loss. Financial liabilities—derecognition A financial liability is derecognized when the obligation under the liability is discharged or canceled or expires. When an existing financial liability is replaced by another from the same lender on substantially different terms, or the terms of an existing liability are substantially modified, such an exchange or modification is treated as the derecognition of the original liability and the recognition of a new liability. The difference in the respective carrying amounts is recognized in the statements of loss.
New standards amendments to standards and interpretations	New standards, amendments to standards and interpretations New standards, amendments to standards, and interpretations issued recently effective As of January 1, 2022 the Annual Improvements to International Financial Reporting Standards (“IFRS”) Standards 2018–2020 (“Annual Improvements”) and the narrowed scope of the (“IFRS”) 3, Business Combinations (“IFRS 3”), IAS 16, Property, plant, and equipment (“IAS 16”), and IAS 37, Provisions, contingent liabilities, and contingent assets (“IAS 37”), as issued by the IASB became effective. The Company assessed the changes to the accounting standard and determined the improvements had no impact on the Company’s financial statements. New standards, amendments to standards, and interpretations issued not yet effective In January 2020, IASB issued amendments to paragraphs 69 to 76 of International Accounting Standard (“IAS”) 1, Presentation of Financial Statements (“IAS 1”), to specify the requirements for classifying liabilities as current or non-current, effective for annual reporting periods beginning on or after January 1, 2023. The Company determined the amendment has no impact.
Revenue	Critical accounting estimates and judgements The Company recognizes revenue when control of promised goods or services is transferred to customers in an amount that reflects the consideration that is expected to be received for those goods or services. Significant judgment is required to determine the stand-alone selling price (“SSP”) for each performance obligation in the SOPHiA DDM Platform, the amount allocated to each performance obligation and whether it depicts the amount that the Company expects to receive in exchange for the related product and/or service. The Company enters into arrangements with multiple performance obligations where it could be difficult to determine the performance obligations under a sales agreement; in such cases, how and when revenue should be recognized is subject to certain estimates or assumptions. Should these judgments and estimates not be correct, revenue recognized for any reporting period could be adversely affected. Accounting policies Revenue represents amounts received and receivable from third parties for goods supplied and services rendered to customers. Revenues are reported net of rebates and discounts and net of sales and value added taxes in an amount that reflects the consideration that is expected to be received for goods or services. The majority of the sales revenue is recognized: (i) when customers generate analyses on their patient data through the SOPHiA DDM Platform, (ii) when consumables, namely DNA enrichment kits, are delivered to customers at which point control transfers, (iii) when services, namely set-up programs, are performed and (iv) over the duration of the software licensing arrangements for the Alamut software offerings. Products and services are sold both directly to customers and through distributors, generally under agreements with payment terms of up to 180 days. Therefore, contracts do not contain a significant financing component. For all contracts with customers the following steps are performed to determine the amount of revenue to be recognized and when it should be recognized: (1) identify the contract or contracts; (2) determine whether the promised goods or services are performance obligations, including whether they are distinct in the context of the contract; (3) measure the transaction price, including the constraint on variable consideration; (4) allocate the transaction price to the performance obligations based on estimated selling prices; and (5) recognize revenue when (or as) each performance obligation is satisfied. SOPHiA DDM Platform The majority of the SOPHiA DDM Platform revenue is derived from each use of the SOPHiA DDM Platform by customers to generate analysis on their patient data. Analysis revenue is recognized as analysis results are made available to the customer on the SOPHiA DDM Platform. The Company recognizes accrued contract revenue in accounts receivable for any analyses performed by customers that have not been invoiced at the reporting date and where the right to consideration is unconditional. Any payments received in advance of customers generating analyses are recorded as deferred contract revenue until the analyses are performed. Customers use the SOPHiA DDM Platform to perform analyses under three different models: dry lab access; bundle access; and integrated solutions. For dry lab contracts, customers use the testing instruments and consumables of their choice and the SOPHiA DDM Platform and algorithms for variant detection and identification. In these arrangements, the Company has identified one performance obligation, which is the delivery of the analysis result to the customer. For bundle arrangements, customers purchase a DNA enrichment kit along with each analysis. Customers use the DNA enrichment kit in the process of performing their own sequencing of each sample. Customers then upload their patient data to the SOPHiA DDM Platform for analysis. In these arrangements, the Company has identified two performance obligations: the delivery of the DNA enrichment kits and the performance of the analyses. Revenue is recognized for the DNA enrichment kits when control of products has transferred to the customer, which is generally at the time of delivery, as this is when title and risk of loss have been transferred. Revenue for the performance of the analyses is recognized on delivery of the analysis results to the customer. Refer to Arrangements with multiple performance obligations below for how revenue is allocated between the performance obligations. Deferred contract revenue balances relating to analyses not performed within 12 months from the date of the delivery date are recognized as revenue. This policy is not based on contractual conditions but on the Company’s experience of customer behavior and expiration of the kits associated with the analyses. For integrated arrangements, customers have their samples processed and sequenced through selected SOPHiA DDM Platform partners within the clinical network and access their data through the SOPHiA DDM Platform. The Company has identified one performance obligation, which is delivery of the analysis results to the customer through the SOPHiA DDM Platform. The Company also sells access to its Alamut software application (“Alamut”) through the SOPHiA DDM Platform. Some arrangements with customers allow customers to use Alamut as a hosted software service over the contract period without the customer taking possession of the software. Other customers take possession of the software, but the utility of that software is limited by access to the Company’s proprietary SOPHiA database, which is provided to the customer on a fixed term basis. Under both models, revenue is recognized on a straight-line basis over the duration of the agreement. The Company also derives revenue from the SOPHiA DDM Platform by providing services to biopharma customers who engage the Company to (i) develop and perform customized genomic analyses and/or (ii) access the database for use in clinical trials and other research projects. The Company does enter into biopharma contracts that contain multiple products or services or non-standard terms and conditions. The biopharma contracts are generally unique in nature and each contract is assessed upon execution. Generally, the primary performance obligation in these arrangements is the delivery of analysis results in the form of a final report, resulting in revenue being recognized, in most cases, upon the issuance of the final report or successful recruitment of clinical trial participants. Workflow materials and services Revenue from workflow materials and services includes all revenue from the sale of materials and services that do not form part of a contract for the provision of platform services. These include the provision of set-up programs and training and the sale of kits and tests that are not linked to use of the platform. Set-up programs and training are typically combined with a customer’s first order prior to the customer beginning to use the SOPHiA DDM Platform. Revenue from services is generally recognized when the services are performed. Revenue from materials is recognized when control of the goods is transferred to the customer, generally at the time of delivery. This category of revenue also includes the revenue from the sale of DNA sequencing automation equipment accounted for under IFRS 16, Leases (“IFRS 16”), leasing and the fees charged for the maintenance of this equipment. Arrangements with multiple performance obligations The Company sells different combinations of analyses, consumables, and services to its customers under its various SOPHiA DDM Platform models. The Company has determined that the stand-alone selling prices for services and DNA enrichment kits are directly observable. For set-up programs and training sold along with dry lab arrangements or bundle arrangements, the stand-alone selling price of these services is determined on a time and materials basis. For DNA enrichment kits sold as part of a bundle, the SSP is based on an expected cost-plus-margin approach of the kit portion of the bundle. The Company has determined that the SSP for the analyses, in both a dry lab arrangement and bundle arrangement, is highly variable and therefore a representative SSP is not discernible from past transactions. As a result, the residual approach is used to determine the stand-alone selling price of the analyses in dry lab arrangements that include services and in bundle arrangements that include DNA enrichment kits and, in some cases, services. The Company also has a small number of bundle contracts with a fixed term that also include providing the customer with DNA sequencing automation equipment, which the Company has determined is an IFRS 16 leasing component. In these arrangements the Company provides DNA sequencing automation equipment to the customer over the fixed term and at completion of the contract term the customer takes possession of the equipment. The Company has determined that it is a dealer lessor and provision of this equipment to the customer is classified as a finance lease. As a result, upon delivery of the leased equipment at the inception of the arrangement, a selling profit is recognized based on the fair value of the underlying equipment less the cost of the equipment. Over the term of the agreement, the minimum lease payment is deducted from the proceeds of the bundle sales in order to reduce the net investment in the corresponding lease receivable over the contract term and interest income is recognized as the discount on the lease receivable unwinds. The remaining proceeds from the contract are accounted for under IFRS 15, Revenue from Contracts with Customers (“IFRS 15”), using the policies described above. Contract Balances Accrued contract revenue Accrued contract revenue is related to unbilled SOPHiA DDM Platform analyses and are recorded in accounts receivable. As of December 31, 2022 and December 31, 2021, accrued contract revenue was $1.5 million and $0.7 million, respectively. The Company recorded no loss allowance related to the accrued contract revenue as of December 31, 2022 and December 31, 2021, respectively Deferred contract costs Deferred contract costs comprise deferred fulfillment costs related to biopharma, prepayments on contracts, and prepaid maintenance costs relating to DNA sequencing automation equipment. Costs are incurred to fulfill obligations under certain contracts once obtained, but before transferring goods or services to the customer. Fulfillment costs are recognized as an asset, provided these costs are not addressed by other accounting standards, if the following criteria are met: (i) the costs relate directly to a contract or an anticipated contract that the Company can specifically identify, (ii) the costs generate or enhance resources of the Company that will be used in satisfying (or continuing to satisfy) performance obligations in the future and (iii) the costs are expected to be recovered. The asset recognized from deferring the costs to fulfill a contract is recorded in the consolidated balance sheet as deferred contract costs within other current assets and amortized on a systematic basis consistent with the pattern of the transfer of the goods or services to which the asset relates, which depends on the nature of the performance obligation(s) in the contract. The amortization of these assets is recorded in cost of revenue. The timing of revenue recognition and billings can result in accrued contract revenue, which are presented within accounts receivable in the consolidated balance sheet and deferred contract revenue which is presented on the face of the consolidated balance sheet. Deferred contract revenue Deferred contract revenue relates to prepayments received from customers before revenue is recognized and is primarily related to SOPHiA DDM Platform analyses invoiced in advance of the customers performing the analyses, deferred Alamut software revenue and progress payments received as part of biopharma contracts. Deferred contract revenue brought forward as of January 1, 2022 and January 1, 2021 amounts to $4.0 million and $2.9 million, respectively. During the twelve months ended December 31, 2022 and 2021 , the Company satisfied the performance obligations associated with that deferred contract revenue to the extent that revenue was recognized of $4.0 million and $2.9 million, respectively. The majority of the platform revenue is derived from contracts with an original expected length of one year or less. However, there are certain biopharma and Alamut contracts in which performance obligations extend over multiple years. The Company has elected to apply the practical expedient not to disclose the value of remaining performance obligations associated with these types of contracts.
Goodwill and Intangible Assets	Critical accounting estimate and judgements Goodwill The Company operates as one segment or as a single cash-generating unit (“CGU”). As a single CGU, goodwill is tested by considering its recoverability in terms of the entire business. Management assesses the recoverable value of goodwill by comparing the Company’s equity value, either from observable market prices or based on discounted cash flow forecasts, to the net assets as reported in the Company’s consolidated financial statements. The value as of October 1, 2022 was based on the Company’s discounted cash flow projections, which in turn were based on historical results and ratios updated to reflect management’s expectations of future growth and profitability and discounted using a weighted average cost of capital derived from an analysis of comparable selected public companies. The value as of October 1, 2021 was based on the Company’s market capitalization which is a factor of the Company’s outstanding shares multiplied by the price of the Company’s stock on October 1, 2021 . Capitalized internally developed software costs Capitalized costs are based on the employment costs of individuals working on software development and based on timesheets. Special attention is paid to distinguishing between costs incurred on developing new software or software upgrades, which may be eligible for capitalization, and costs incurred in maintenance and in the correction of problems, which is not eligible. Judgement is required in identifying whether individual projects meet all of the criteria required to permit capitalization, in particular, whether the software will generate probable future economic benefits. Accounting policies Goodwill Goodwill is initially measured as the difference between the aggregate of the value of the consideration transferred and the fair value of net assets acquired. Goodwill is not amortized but it is tested for impairment annually, or more frequently if events or changes in circumstances indicate that it might be impaired and is carried at cost less accumulated impairment losses. Gains and losses on the disposal of an entity include the carrying amount of goodwill relating to the entity sold. Impairment testing Intangible assets are allocated to CGUs for the purpose of impairment testing. The allocation is made to those CGUs or groups of CGUs that are expected to benefit from the business combination in which the goodwill arose. The CGUs or groups of CGUs are identified at the lowest level at which goodwill is monitored for internal management purposes, being the operating segments. As the Company operates as a single operating segment or CGU, the Company has only a single cash generating unit for impairment testing. Management assesses the recoverable value of goodwill by comparing the value of the Company equity value, either inferred from the public prices of share issues based on the fair value less cost of disposal (“FVLCOD”) method or based on discounted cash flow forecasts, with the net assets as reported in its consolidated financial statements based on the value in use (“ViU”) method). The Company typically compares the two methods and utilizes the greater recoverable amount for the purposes of its impairment testing. Impairment testing is performed on an annual basis as of October 1 . The discounted cash flow approach involves key assumptions that leave considerable scope for judgement. The Company used the discounted cash flow method for the fiscal year ended as of December 31, 2022. Purchased software The costs of accessing software services are not capitalized if the Company does not have any contractual right to take possession of the software at any time during the term of the agreement and it is not feasible for the Company either to run the software on its own hardware or to contract with a third party unrelated to the vendor. Such costs represent software as a service costs and are expensed as incurred. The Company does capitalize software implementation costs, such as fees paid to outside consultants to set up a software arrangement. For cloud computing costs, the Company capitalized costs for certain configuration and customization costs paid by a customer in a cloud computing or hosting arrangement. The guidance aligns the accounting treatment of these costs incurred in a hosting arrangement treated as a service contract with the requirements for capitalization and amortization costs to develop or obtain an intangible asset. Purchased software and associated capitalized costs are amortized using the straight-line method over an estimated life of five years. Capitalized internally developed software costs Costs incurred in the internal development of software are capitalized as intangible assets when the criteria required by IAS 38 as set out below. Software development costs consist entirely of capitalized internally generated costs that are directly attributable to the design, testing and enhancement of identifiable and unique software applications and products controlled by the Company and incorporated principally within the Company’s SOPHiA DDM Platform. They are recognized as intangible assets where the following criteria are met: • it is technically feasible to complete software so that it will be available for use; • management intends to complete the software and use or sell it; • there is an ability to use or sell the software; • it can be demonstrated how the software will generate probable future economic benefits; • adequate technical, financial and other resources to complete the development and to use or sell the software are available, and; • the expenditure attributable to the software during its development can be reliably measured. Directly attributable costs that are capitalized as part of the software comprise principally employee costs. Capitalized development costs are recorded as intangible assets and amortized from the point at which the asset is ready for use on a straight-line basis over its expected useful life. Capitalized software development costs are amortized using the straight-line method over an estimated life of five years. The Company considers that it is only since the beginning of 2020 that development costs have fulfilled the criteria for recognition as intangible assets set out in IAS 38.
Post-employment benefits	Significant accounting estimates and judgements The liability or asset recognized in the balance sheet in respect of defined benefit pension plans is the present value of the defined benefit obligation at the end of the reporting period less the fair value of plan assets. The defined benefit obligation is calculated annually by independent actuaries using the projected unit credit method. The present value of the defined benefit obligation is determined by discounting the estimated future cash outflows using interest rates of high-quality corporate bonds that are denominated in the currency in which the benefits will be paid, and that have terms approximating to the terms of the related obligation. In countries where there is no deep market in such bonds, the market rates on government bonds are used. The net interest cost is calculated by applying the discount rate to the net balance of the defined benefit obligation and the fair value of plan assets. This cost is included in employee benefit expense in the statement of income/loss. Remeasurement gains and losses arising from experience adjustments and changes in actuarial assumptions are recognized in the period in which they occur, directly in other comprehensive income. The remeasurement gains and losses are included in retained earnings in the statement of changes in equity and in the balance sheet. Changes in the present value of the defined benefit obligation resulting from plan amendments or curtailments are recognized immediately in income as past service costs. For defined contribution plans, the Company pays contributions to publicly or privately administered pension insurance plans. Employee contributions to these plans is voluntary and these contributions are matched by the employer. The Company has no further payment obligations once the contributions have been paid. The contributions are recognized as employee benefit expense when they are due. Prepaid contributions are recognized as an asset to the extent that a cash refund or a reduction in the future payments is available. Contributions are charged to the statement of income/loss as incurred. Accounting policies The Company operates defined benefit and defined contribution pension plans. Funded schemes are generally funded through payments to insurance companies or trustee-administered funds, determined by periodic actuarial calculations. A defined contribution plan is a pension plan under which the Company pays fixed contributions into a separate entity (a fund) and has no legal or constructive obligations to pay further contributions if the fund does not hold sufficient assets to pay all employees the benefits relating to employee service in the current and prior periods. A defined benefit plan is a pension plan that is not a defined contribution plan. Typically, defined benefit plans define an amount of pension benefit that an employee will receive on retirement, usually dependent on one or more factors such as age, years of service and compensation. The actual return on plan assets, excluding interest income measured at the discount rate, is recognized in other comprehensive income/loss within defined benefit plan remeasurements. The Company has a funded defined benefit plan in Switzerland, an unfunded defined benefit plan in France and a defined contribution plans in the US. The Company has no occupational pension plans in the UK and Brazil. Swiss pension plan The Company contracted with the Swiss Life Collective BVG Foundation based in Zurich for the provision of occupational benefits. All benefits in accordance with the regulations are reinsured in their entirety with Swiss Life SA within the framework of the corresponding contract. This pension solution fully reinsures the risks of disability, death and longevity with Swiss Life. Swiss Life invests the vested pension capital and provides a 100% capital and interest guarantee. The pension plan is entitled to an annual bonus from Swiss Life comprising the effective savings, risk and cost results. Although the amount of ultimate pension benefit is not defined, certain legal obligations of the plan create constructive obligations on the employer to pay further contributions to fund an eventual deficit; this results in the plan nevertheless being accounted for as a defined benefit plan. French pension plan In France, the bulk of pensions are paid by national pension schemes, which are unfunded. In addition, French employers are obliged by law to pay a retirement indemnity. Its amount depends on the last salary of the employee and on the period of activity with its employer. Rights to this benefit are acquired during the service life with the same employer on the condition that the employee will be with its employer at retirement date; it means that the rights are only vested on retirement date. This indemnity is in substance a defined benefit plan.

Company information and opera_2

Company information and operations (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure Of Company Information And Operations [Abstract]
Summary of Wholly-Owned Subsidiaries	As of December 31, 2022, the Company had the following wholly-owned subsidiaries: Name Country of domicile SOPHiA GENETICS S.A.S. France SOPHiA GENETICS LTD UK SOPHiA GENETICS, Inc. USA SOPHiA GENETICS Intermediação de Negócios LTDA Brazil SOPHiA GENETICS PTY LTD Australia SOPHiA GENETICS S.R.L. Italy

Segment reporting (Tables)

Segment reporting (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of operating segments [abstract]
Summary of Revenue and Non-Current Non-Financial Assets by Country	An analysis of the location of non-current assets other than financial instruments and deferred tax assets by country is as follows (in USD thousands): Year ended December 31, 2022 2021 Switzerland $ 39,052 $ 28,973 France 498 290 United States 1,803 2,357 Brazil 6 8 Total non-current assets other than financial instruments and deferred tax assets $ 41,359 $ 31,628

Revenue (Tables)

Revenue (Tables)	12 Months Ended
	Dec. 31, 2022
Receivables from contracts with customers [abstract]
Schedule of Revenue from Contracts with Customers Allocated to Geographical Areas and Revenue Streams	The following tables disaggregate the Company's revenue from contracts with customers by geographic market (in USD thousands): Year ended December 31, 2022 2021 2020 EMEA $ 34,878 $ 31,583 $ 22,073 NORAM 6,732 4,730 2,923 LATAM 3,003 2,295 2,131 APAC 2,947 1,842 1,273 Total revenue $ 47,560 $ 40,450 $ 28,400 Revenue streams The Company’s revenue from contracts with customers has been allocated to the revenue streams indicated in the table below (in USD thousands): Year ended December 31, 2022 2021 2020 SOPHiA DDM Platform $ 45,679 $ 39,465 $ 27,221 Workflow equipment and services 1,881 985 1,179 Total revenue $ 47,560 $ 40,450 $ 28,400

Operating expense (Tables)

Operating expense (Tables)	12 Months Ended
	Dec. 31, 2022
Analysis of income and expense [abstract]
Summary of Operating Expenses	The table presents operating expenses by nature (in USD thousands): For the year ended December 31, 2022 2021 2020 Changes in inventories of finished goods and work in progress $ 47 $ 568 $ (259) Raw materials and consumables used (13,341) (9,650) (3,843) Employee benefit expenses (59,333) (53,802) (36,732) Social charges (11,480) (8,373) (6,983) COVID—salaries reimbursement — — 1,129 Research tax credit 1,292 1,597 763 Share-based compensation (13,613) (8,514) (1,359) Depreciation (3,791) (2,517) (1,758) Amortization (1,780) (1,092) (632) Professional fees (13,837) (11,318) (5,371) Office expenses (6,635) (5,333) (2,006) Travel (3,217) (1,576) (1,361) Marketing (2,213) (1,493) (972) Licenses (3,949) (2,021) (1,647) Less: capitalized software development costs ("Note 17 - Intangible assets”) 5,820 3,858 2,436 Other expense (9,730) (12,381) (7,099) Total $ (135,760) $ (112,047) $ (65,694)
Summary of Depreciation and Amortization have Charged in Expense	Depreciation and amortization have been charged in the following expense categories (in USD thousands): For the year ended December 31, 2022 2021 2020 Depreciation Amortization Depreciation Amortization Depreciation Amortization Cost of revenue $ — $ (1,133) $ — $ (483) $ — $ (111) Research and development costs (1,748) — (1,028) — (727) — Selling and marketing costs (906) — (744) — (543) — General and administrative costs (1,137) (647) (745) (609) (488) (521) Total $ (3,791) $ (1,780) $ (2,517) $ (1,092) $ (1,758) $ (632)
Summary of Employee Benefit Expenses, Social Charges and Share-based Compensation from the Operating Expense	The table presents employee costs by function, which consists of “Employee benefit expenses”, “Social charges” and “Share-based compensation” from the operating expense table (in USD thousands): For the year ended December 31, 2022 2021 2020 Research and development costs $ 29,169 $ 23,899 $ 16,109 Selling and marketing costs 20,216 21,659 12,085 General and administrative costs 35,041 25,131 16,880 Total $ 84,426 $ 70,689 $ 45,074

Finance income (expense), net (

Finance income (expense), net (Tables)	12 Months Ended
	Dec. 31, 2022
Finance Expense Net [Abstract]
Schedule of Finance Expense, Net	December 31, 2022 2021 2020 Interest income $ 1,324 $ 20 $ 96 Total interest income $ 1,324 $ 20 $ 96 Interest on loans — (120) (513) Interest on lease liabilities (422) (225) (121) Other interest (217) (313) (206) Total interest expense $ (639) $ (658) $ (840) Derivative fair value (losses) — (1,444) (384) Foreign exchange gains (losses), net (447) 64 (2,710) Total finance income (expense), net $ 238 $ (2,018) $ (3,838)

Income tax (Tables)

Income tax (Tables)	12 Months Ended
	Dec. 31, 2022
Major components of tax expense (income) [abstract]
Summary of Current and Deferred Tax (Expenses) Benefits	The following table presents the current and deferred tax (expense) benefits (in USD thousands): For the year ended December 31, 2022 2021 2020 Current income tax expense Current year $ (310) $ — $ — Uncertain tax positions 328 (110) (74) Total current income tax expense $ 18 $ (110) $ (74) Deferred income tax (expense) benefit Origination and reversal of temporary differences $ 118 $ (58) $ 1,960 Total deferred income tax (expense) benefit $ 118 $ (58) $ 1,960 Total income tax (expense) benefit $ 136 $ (168) $ 1,886
Reconciliation of Expected Tax Expense to Tax Expense Report in Statement of Loss	The following table presents the reconciliation of the expected tax expense to the tax expense report in the statement of loss (in USD thousands): For the year ended December 31, 2022 2021 2020 Loss before tax $ (87,585) $ (73,507) $ (41,225) Tax at Swiss statutory rate 11,749 9,907 5,541 Effect of tax rates in foreign jurisdictions (292) (218) (177) Tax effect of: Unrecognized deferred tax assets (9,386) (9,077) (3,276) Income not subject to tax (expense not deductible for tax purposes) (1,940) (805) 41 Uncertain tax positions 328 (110) (74) Recognition of deferred tax assets from previously unrecognized tax assets 509 — — 2018-2019 French tax assessment (427) — — Other (405) 135 (169) Income tax (expense)/benefit $ 136 $ (168) $ 1,886
Summary of Movement in Deferred Tax Balances	The following table presents the changes in the Company’s deferred tax assets and deferred tax liabilities (in USD thousands): Depreciation & Bad debt reserves Accrued pension ROU asset Lease liability Other Net operating loss Total January 1, 2022 $ (29) $ 341 $ 44 $ (352) $ 630 $ 96 $ 1,260 $ 1,990 Recognized in profit or loss (50) (324) 26 60 (119) 725 (201) 117 Recognized in OCI — — (59) — — — — (59) Currency translation differences (1) (17) (2) (10) 31 (109) (108) December 31, 2022 $ (80) $ — $ 9 $ (302) $ 511 $ 852 $ 950 $ 1,940 Deferred tax assets 9 511 940 950 2,410 Deferred tax liabilities (80) — — (302) — (88) — (470) Depreciation & Bad debt reserves Accrued pension ROU asset Lease liability Other Net operating loss Total January 1, 2021 $ 288 $ 433 $ 35 $ (311) $ 301 $ (10) $ 1,378 $ 2,114 Recognized in profit or loss (309) (65) 12 (34) 331 38 (31) (58) Currency translation differences (8) (27) (3) (7) (2) 68 (87) (66) December 31, 2021 $ (29) $ 341 $ 44 $ (352) $ 630 $ 96 $ 1,260 $ 1,990 Deferred tax assets — 341 44 — 630 361 1,260 2,636 Deferred tax liabilities (29) — — (352) — (265) — (646) December 31, 2022 2021 Gross amount Tax effect Gross amount Tax effect Deductible temporary differences $ 3,385 $ 511 $ 5,101 $ 729 Net operating loss carryforwards 263,486 34,224 202,394 28,597 Total $ 266,871 $ 34,735 $ 207,495 $ 29,326
Summary of Expiring Amounts of Unrecognized Net Operating Loss Carryforwards	As of December 31, 2022 and December 31, 2021, the Company had the following expiring amounts of unrecognized NOL carryforwards (in USD thousands): December 31, 2022 2021 One year $ 12,007 $ 7,625 Two years 16,261 12,170 Three years 15,561 16,482 Four years 23,515 15,772 Thereafter and unlimited 196,142 150,345 Net operating loss carryforwards $ 263,486 $ 202,394

Loss per share (Tables)

Loss per share (Tables)	12 Months Ended
	Dec. 31, 2022
Earnings per share [abstract]
Components of Loss for Year	The table presents the loss for the year ended December 31, 2022, 2021, and 2020, respectively (in USD thousands, except shares and loss per share): Year ended December 31, 2022 2021 2020 Net loss attributed to shareholders $ (87,449) $ (73,675) $ (39,339) Weighted average number of shares in issue 64,099,213 55,299,863 42,350,757 Basic and diluted loss per share $ (1.36) $ (1.33) $ (0.93)

Cash and cash equivalents (Tabl

Cash and cash equivalents (Tables)	12 Months Ended
	Dec. 31, 2022
Cash and cash equivalents [abstract]
Schedule of Cash and Cash Equivalents	The following table presents the allocation between the Company’s cash and cash equivalents (in USD thousands): December 31, 2022 2021 Cash $ 25,820 $ 39,578 Cash equivalents 135,485 153,384 Cash and cash equivalents $ 161,305 $ 192,962

Term deposits (Tables)

Term deposits (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure Of Term Deposits [Abstract]
Allocation Between Company's Term Deposits	The following table presents the allocation between the Company’s term deposits (in USD thousands): December 31, 2022 2021 Term deposits, over 3 months, up to 12 months $ 17,307 $ 72,357 Total term deposits $ 17,307 $ 72,357

Accounts receivable (Tables)

Accounts receivable (Tables)	12 Months Ended
	Dec. 31, 2022
Trade and other receivables [abstract]
Schedule of Accounts Receivable and Lease Receivable Less Expected Credit Loss	The following table presents the accounts receivable and lease receivable less the expected credit loss (in USD thousands): December 31, 2022 December 31, 2021 Accounts receivable $ 6,060 $ 7,060 Accrued contract revenue 1,499 657 Lease receivable 185 237 Allowance for expected credit losses (1,095) (1,676) Net accounts receivable $ 6,649 $ 6,278
Schedule of Movement in Allowance for Expected Credit Losses in Accounts Receivable	The movement in the allowance for expected credit losses in accounts receivable is presented below (in USD thousands): 2022 2021 As of January 1 $ 1,676 $ 2,664 Increase 404 1,273 Reversals (804) (1,612) Write-off (67) (572) Currency translation differences (114) (77) As of December 31 $ 1,095 $ 1,676

Inventory (Tables)

Inventory (Tables)	12 Months Ended
	Dec. 31, 2022
Classes of current inventories [abstract]
Schedule of Inventory	Inventory consists of the following (in USD thousands): December 31, 2022 2021 Raw materials $ 5,195 $ 5,105 Work in progress 1,340 1,330 Finished goods 124 87 Provision (1,503) (793) Total $ 5,156 $ 5,729
Schedule of Inventory Provision Movement	Inventory provision movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): 2022 2021 As of January 1 $ (793) $ (713) Increase in provision (697) (105) Currency Translation Adjustment (13) 25 As of December 31 $ (1,503) $ (793)

Prepaids and other current as_2

Prepaids and other current assets (Tables)	12 Months Ended
	Dec. 31, 2022
Prepaids And Other Current Assets [Abstract]
Summary of Other Current Assets	The following table presents the other current assets (in USD thousands): December 31, 2022 December 31, 2021 Deferred contract costs $ — $ 150 Prepayments 3,703 3,943 VAT receivable 1,244 811 Government grants receivable 160 — Other 731 625 Total $ 5,838 $ 5,529

Property and equipment (Tables)

Property and equipment (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about property, plant and equipment [abstract]
Summary of Property and Equipment, Net	Property and equipment, net movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): Leasehold improvements Machinery and equipment Computer hardware Furniture and fixtures Total January 1, 2022 $ 3,260 $ 1,116 $ 1,855 $ 1,007 $ 7,238 Additions 2,895 480 147 222 3,744 Disposals — — (319) (113) (432) Currency Translation Adjustment 27 30 (50) (8) (1) December 31, 2022 $ 6,182 $ 1,626 $ 1,633 $ 1,108 $ 10,549 Accumulated depreciation January 1, 2022 $ (570) $ (418) $ (1,228) $ (359) $ (2,575) Additions (588) (224) (273) (206) (1,291) Disposals — — 319 113 432 Currency Translation Adjustment (7) (23) 39 5 14 December 31, 2022 $ (1,165) $ (665) $ (1,143) $ (447) $ (3,420) Net book value at December 31, 2022 $ 5,017 $ 961 $ 490 $ 661 $ 7,129 Leasehold improvements Machinery and equipment Computer hardware Furniture and fixtures Total January 1, 2021 $ 890 $ 615 $ 1,799 $ 623 $ 3,927 Additions 2,447 608 421 420 3,896 Disposals (49) (85) (294) (31) (459) Currency Translation Adjustment (28) (22) (71) (5) (126) December 31, 2021 $ 3,260 $ 1,116 $ 1,855 $ 1,007 $ 7,238 Accumulated depreciation January 1, 2021 $ (258) $ (398) $ (1,230) $ (269) $ (2,155) Additions (352) (119) (341) (130) (942) Disposals 29 85 292 31 437 Currency Translation Adjustment 11 14 51 9 85 December 31, 2021 $ (570) $ (418) $ (1,228) $ (359) $ (2,575) Net book value at December 31, 2021 $ 2,690 $ 698 $ 627 $ 648 $ 4,663

Intangibles assets (Tables)

Intangibles assets (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about intangible assets [abstract]
Intangible Assets Net, Movement	Intangible assets, net movement for the years ended December 31, 2022 and 2021, respectively are as follows (in USD thousands): Goodwill Purchased software Capitalized internally developed software costs Total intangible assets January 1, 2022 $ 8,298 $ 3,090 $ 6,359 $ 17,747 Additions — 464 5,820 6,284 Disposals — — (80) (80) Currency Translation Adjustment (110) (24) 92 (42) December 31, 2022 $ 8,188 $ 3,530 $ 12,191 $ 23,909 Accumulated amortization January 1, 2022 $ — $ (1,432) $ (642) $ (2,074) Additions — (618) (1,162) (1,780) Disposals — — 7 7 Currency Translation Adjustment — (2) (97) (99) December 31, 2022 $ — $ (2,052) $ (1,894) $ (3,946) Net book value at December 31, 2022 $ 8,188 $ 1,478 $ 10,297 $ 19,963 Goodwill Purchased software Capitalized internally developed software costs Total intangible assets January 1, 2021 $ 8,598 $ 3,071 $ 2,621 $ 14,290 Additions — 130 3,858 3,988 Disposals — — (30) (30) Currency Translation Adjustment (300) (111) (90) (501) December 31, 2021 $ 8,298 $ 3,090 $ 6,359 $ 17,747 Accumulated amortization January 1, 2021 $ — $ (889) $ (119) $ (1,008) Additions — (565) (527) (1,092) Currency Translation Adjustment — 22 4 26 December 31, 2021 $ — $ (1,432) $ (642) $ (2,074) Net book value at December 31, 2021 $ 8,298 $ 1,658 $ 5,717 $ 15,673

Leases (Tables)

Leases (Tables)	12 Months Ended
	Dec. 31, 2022
Presentation of leases for lessee [abstract]
Schedule of Movements in Right of Use Assets	The following table presents the movements in the ROUs (in USD thousands): 2022 2021 As of January 1 $ 11,292 $ 3,767 Additions 5,388 9,205 Depreciation charge (2,500) (1,575) Currency translation effects 88 (105) As of December 31 $ 14,268 $ 11,292
Schedule of Movements in Lease Liabilities	The following table presents the movements in the lease liabilities (in USD thousands): 2022 2021 As of January 1 $ 13,059 $ 3,919 Additions 5,441 10,165 Cash outflows (principle and interest) (2,316) (1,143) Non-cash interest 422 225 Currency translation effects 137 (107) As of December 31 $ 16,743 $ 13,059

Accounts payable (Tables)

Accounts payable (Tables)	12 Months Ended
	Dec. 31, 2022
Subclassifications of assets, liabilities and equities [abstract]
Summary of Accounts Payable	Accounts consist of the following (in USD thousands): December 31, 2022 December 31, 2021 Trade payables $ 2,170 $ 2,337 Employee related payables 3,655 3,509 VAT and sales taxes 356 891 Total $ 6,181 $ 6,737

Accrued expenses (Tables)

Accrued expenses (Tables)	12 Months Ended
	Dec. 31, 2022
Accrued Expenses [Abstract]
Summary of Accrued Expenses	Accrued expenses consist of the following (in USD thousands): December 31, 2022 December 31, 2021 Accrued Compensation $ 10,268 $ 9,148 Accrued Professional fees 2,162 2,743 Accrued inventory purchases 315 2,472 Accrued IT support 22 25 Accrued Legal fees 287 125 Accrued Other 1,451 1,459 Total $ 14,505 $ 15,972

Other non-current assets (Table

Other non-current assets (Tables)	12 Months Ended
	Dec. 31, 2022
Miscellaneous non-current assets [abstract]
Schedule of Other Non-Current Assets	Other non-current assets consist of the following (in USD thousands): December 31, 2022 2021 Research tax credit receivable $ 3,342 $ 2,295 Guarantee deposit 941 1,405 Total $ 4,283 $ 3,700

Post-employment benefits (Table

Post-employment benefits (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure Of Information About Post Employment Benefits [Abstract]
Summary of Additional Details on Defined Pension Plans Funded Status	The following table provides additional details on the defined pension plans’ funded status (in USD thousands): December 31, 2022 2021 Present value of defined benefit obligation $ (19,252) $ (17,889) Fair value of plan assets 16,577 13,436 Net pension liability $ (2,675) $ (4,453)
Disclosure of Movement in Defined Benefit Obligation Explanatory	The following table presents the movement in the defined benefit obligation (in USD thousands): 2022 2021 Funded Unfunded Total Funded Unfunded Total January 1 $ (17,686) $ (203) $ (17,889) $ (15,773) $ (165) $ (15,938) Service Cost (1,759) (90) (1,849) (1,054) (80) (1,134) of which current service cost (1,873) (90) (1,963) (1,382) (80) (1,462) of which past service cost 114 — 114 328 — 328 Interest expense (154) (2) (156) (49) (1) (50) Actuarial gains (losses) 2,110 250 2,360 471 26 497 Actual plan participants’ contributions (1,361) — (1,361) (1,171) — (1,171) Transfers (in) out due to (joiners) leavers (551) — (551) (651) — (651) Currency translation differences 180 14 194 541 17 558 December 31 $ (19,221) $ (31) $ (19,252) $ (17,686) $ (203) $ (17,889) The table below presents the sensitivity analysis for the unfunded plans (in USD thousands): 2022 2021 Discount rates Increase of 50 basis points (2) (26) Decrease of 50 basis points 2 30 Expected rates of salary increases Increase of 50 basis points 3 30 Decrease of 50 basis points (2) (26)
Summary of Movement in Defined Benefit Plans Assets	The following table presents the movement in the defined benefit plans’ assets (in USD thousands): 2022 2021 As of January 1 $ 13,436 $ 10,780 Interest income 125 39 Return on plan assets, excl. interest income (204) (32) Administrative expenses (71) (62) Employer contributions 1,452 1,257 Employee contributions 1,361 1,171 Transfers in (out) due to joiners (leavers) 551 651 Currency translation differences (73) (368) As of December 31 $ 16,577 $ 13,436
Summary of Defined Benefit Plans Assets	The following table presents the defined benefit plan assets, which include the following (in USD thousands): December 31, 2022 2021 Cash $ 664 $ 528 Insurance policies 15,913 12,908 Total $ 16,577 $ 13,436
Schedule of Pension Costs Recognized in Statement of Loss	The follow table presents the pension costs recognized in statement of loss (in USD thousands): December 31, 2022 2021 2020 Funded Unfunded Total Funded Unfunded Total Funded Unfunded Total Service cost $ (1,759) $ (90) $ (1,849) $ (1,054) $ (80) $ (1,134) $ (1,547) $ (49) $ (1,596) Interest cost (154) (2) (156) (49) (1) (50) (6) (1) (7) Total recognized $ (1,913) $ (92) $ (2,005) $ (1,103) $ (81) $ (1,184) $ (1,553) $ (50) $ (1,603)
Schedule of Pension Remeasurement Recognized in Statement Other Comprehensive Loss	The follow table presents the pension remeasurement recognized in statement other comprehensive loss (in USD thousands): December 31, 2022 2021 2020 Funded Unfunded Total Funded Unfunded Total Funded Unfunded Total Changes in demographic assumptions $ — $ 223 $ 223 $ 1,278 $ — $ 1,278 $ 1,039 $ — $ 1,039 Changes in financial assumptions 2,311 12 2,323 37 13 50 157 (16) 141 Experience adjustments (201) 15 (186) (844) 13 (831) (952) (14) (966) Total actuarial gains (losses) 2,110 250 2,360 471 26 497 244 (30) 214 Return on plan assets (204) — (204) (32) — (32) (45) — (45) Currency translation differences (4) 2 (2) (4) — (4) 13 2 15 Total recognized $ 1,902 $ 252 $ 2,154 $ 435 $ 26 $ 461 $ 212 $ (28) $ 184
Schedule of Sensitivity Analysis for Funded and Unfunded Plans	The table below presents the sensitivity analysis for the funded plans (in USD thousands): 2022 2021 Discount rates Increase of 25 basis points (426) (576) Decrease of 25 basis points 467 635 Expected rates of salary increases Increase of 25 basis points 110 122 Decrease of 25 basis points (107) (120) Interest rate Increase of 25 basis points 150 189 Decrease of 25 basis points (146) (185) Inflation Increase of 25 basis points 102 121 Decrease of 25 basis points (99) (118) Life expectancy Increase of 1 year 71 145 Decrease of 1 year (71) (145)

Share-based compensation (Table

Share-based compensation (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of terms and conditions of share-based payment arrangement [abstract]
Summary of Stock Option Activity	Activity for the year ended December 31, 2022, under the 2013 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 859,540 $ 2.75 5.08 Exercised (193,560) 2.44 — Forfeited (8,000) 3.19 — Outstanding as of December 31, 2022 657,980 $ 2.92 4.24 Exercisable as of December 31, 2022 657,980 $ 2.92 4.24 Activity for the year ended December 31, 2021, under the 2013 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 1,751,560 $ 3.10 6.39 Exercised (892,020) 3.00 — Outstanding as of December 31, 2021 859,540 $ 2.75 5.08 Exercisable as of December 31, 2021 849,540 $ 2.75 5.06 Activity for the year ended December 31, 2022, under the 2019 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 2,812,500 $ 5.83 8.61 Exercised (47,000) 7.25 — Forfeited (135,984) 5.15 — Outstanding as of December 31, 2022 2,629,516 $ 4.96 7.21 Exercisable as of December 31, 2022 1,476,744 $ 4.41 6.56 Activity for the year ended December 31, 2021, under the 2019 ISOP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 1,972,500 $ 4.22 9.11 Granted 1,369,000 8.75 9.12 Forfeited (149,750) 5.54 — Exercised (379,250) 4.00 — Outstanding as of January 1, 2021 2,812,500 $ 5.83 8.61 Exercisable as of December 31, 2021 455,500 $ 1.37 7.85 Activity for the year ended December 31, 2022, under the 2021 EIP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2022 1,576,069 $ 17.96 9.57 Granted 1,336,284 6.03 — Forfeited (288,056) 14.00 — Outstanding as of December 31, 2022 2,624,297 $ 12.32 8.88 Exercisable as of December 31, 2022 528,693 17.98 8.04 Activity for the year ended December 31, 2021, under the 2021 EIP was as follows: Number of options Weighted average exercise price Weighted average remaining life in years Outstanding as of January 1, 2021 — $ — — Granted 1,595,314 17.96 9.57 Forfeited (19,245) 18.00 — Outstanding as of January 1, 2021 1,576,069 $ 17.96 9.57 Exercisable as of December 31, 2021 — $ — —
Summary of Valuation Inputs	The valuation inputs for the 2019 ISOP grants were as follows: Twelve months ended December 31, 2022 2021 2020 Share price at grant date (in USD) N/A $5.59 $4.36 - $4.87 Expected life of share options (years) N/A 6.05 - 6.19 5.67 - 6.43 Expected volatility N/A 41.26% - 41.45% 39.84% - 43.56% Risk free interest rate N/A (0.63)% - (0.48)% (0.80)% - (0.53)% Dividend yield (%) N/A —% —% The valuation inputs for the 2021 EIP grants were as follows:: Year Ended December 31, 2022 2021 Share price at grant date (in USD) $2.06 - $8.36 $16.81 - $18.00 Expected life of share options (years) 5.50 - 7.00 5.50 - 7.00 Expected volatility 62.65% - 69.43% 41.65% - 59.77% Risk free interest rate 2.42% - 4.00% 0.87% - 1.36% Dividend yield (%) —% —%
Weighted Average Fair Value of Options Granted	The weighted average fair value of options granted during the years ended December 31, 2022 and 2021, respectively (in USD): 2022 2021 2019 ISOP N/A $ 2.12 2021 EIP $ 3.62 $ 9.87
Movements in Share-based Compensation Reserve	Movements in the share-based compensation reserve were as follows (in USD thousands): Total January 1, 2021 $ 2,948 Movement in the period 8,514 December 31, 2021 11,462 Movement in the period 13,613 December 31, 2022 $ 25,075 Share-based compensation expense by financial statement caption for all stock awards consists of the following (in USD thousands): Year ended December 31, 2022 2021 2020 Research and development $ 2,245 $ 784 $ 149 Sales and marketing 1,462 1,227 212 General and administrative 9,906 6,503 998 Total $ 13,613 $ 8,514 $ 1,359
Summary of Restricted Stock Units Activity	The activity for the year ended December 31, 2022 was as follows: Number of RSUs Weighted-average grant date fair value per share Unvested as of January 1, 2022 287,575 $ 17.97 Granted 1,776,832 4.30 Vested (133,056) 17.99 Forfeited (65,918) 10.72 Unvested as of December 31, 2022 1,865,433 $ 5.20 The activity for the year ended December 31, 2021 was as follows: Number of RSUs Weighted-average grant date fair value per share Unvested as of January 1, 2021 — $ — Granted 290,407 17.97 Forfeited (2,832) 18.00 Unvested as of December 31, 2021 287,575 $ 17.97

TriplePoint success fee (Tables

TriplePoint success fee (Tables)	12 Months Ended
	Dec. 31, 2022
Triple Point Success Fee [Abstract]
Summary of Loss Recognized on Derivative with TriplePoint Loan	The following table presents the loss recognized by the Company on the derivative associated with the TriplePoint loan (in USD thousands): 2022 2021 2020 As of January 1 $ — $ 1,024 $ 557 Loss on derivative — 1,444 467 As of December 31 $ — $ 2,468 $ 1,024

Related parties (Tables)

Related parties (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of transactions between related parties [abstract]
Summary of Compensation for Key Management and Non-executive Directors	Compensation for key management and non-executive directors recognized during the year comprised (in USD thousands): December 31, 2022 2021 2020 Salaries and other short-term employee benefits $ 3,368 $ 2,761 $ 1,155 Pension costs 196 117 70 Share-based compensation expense 8,936 6,906 1,065 Other compensation 414 44 146 Total $ 12,914 $ 9,828 $ 2,436
Summary of Related Parties Participated in Sale of Series F Preferred Shares	Related parties participated in the sale of Series F preferred shares during 2020 to the following extent: Name of shareholder Number of preferred shares purchased Alychlo NV 233,580 Generation IM Sustainable Fund III, L.P 389,300 Total 622,880

Financial instruments and ris_2

Financial instruments and risks (Tables)	12 Months Ended
	Dec. 31, 2022
Disclosure of detailed information about financial instruments [abstract]
Schedule of Financial Instruments	The Company holds the following financial instruments (in USD thousands): December 31, 2022 2021 Financial assets at amortized cost Cash and cash equivalents $ 161,305 $ 192,962 Term deposits 17,307 72,357 Accounts receivable 6,649 5,621 Other financial non-current assets 965 1,405 Total financial assets at amortized cost $ 186,226 $ 272,345 Financial assets at fair value through statement of loss Total financial assets $ 186,226 $ 272,345 Financial liabilities at amortized cost Accounts payable 6,181 6,737 Accrued expenses 14,505 15,972 Lease liabilities 16,743 13,059 Total financial liabilities at amortized cost 37,429 35,768 Financial liabilities at fair value through statement of loss Total financial liabilities $ 37,429 $ 35,768
Summary of Maturity Profile of Financial Liabilities	The table below summarizes the maturity profile of the Company’s financial liabilities based on contractual undiscounted cash flows (in USD thousands): Net carrying amount Within 1 year Between 1 and 5 years After 5 years Total December 31, 2022 Lease liabilities $ 16,743 $ 2,950 $ 8,862 $ 6,421 $ 18,233 Accounts payable 6,181 6,181 — — 6,181 Accrued expenses 14,505 14,505 — — 14,505 Total contractual liabilities $ 37,429 $ 23,636 $ 8,862 $ 6,421 $ 38,919 December 31, 2021 Lease liabilities $ 13,059 $ 2,018 $ 8,467 $ 4,075 $ 14,560 Accounts payable 6,737 6,737 — — 6,737 Accrued expenses 15,972 15,972 — — 15,972 Total contractual liabilities $ 35,768 $ 24,727 $ 8,467 $ 4,075 $ 37,269
Summary of Significant Foreign Exchange Rates	The significant exchange rates that have been applied to these consolidated financial statements are listed below: December 31, For the twelve months ended December 31, 2022 2021 2022 2021 2020 Currency Spot rate Spot rate Average rate Average rate Average rate USD/CHF 0.92447 0.91210 0.95500 0.91437 0.94703 USD/EUR 0.93414 0.88290 0.95146 0.84579 0.88423 USD/GBP 0.82761 0.74190 0.81177 0.72707 0.78132 USD/BRL 5.28600 5.57130 5.16678 5.39288 5.06281
Sensitivity of Loss Before Tax to Changes in Foreign Exchange Rates	The sensitivity of the Company’s income to possible changes in foreign exchange rates is measured at the local entity level as it depends on the functional currency of each entity. As of December 31, 2022 and 2021 , the Company was exposed principally to movements in four cross currency pairs. The sensitivity of the Company’s loss before tax to such changes was as follows (in USD thousands): December 31, 2022 2021 2020 Increase / (decrease) in USD/CHF exchange rate by 10% 6,614 / (6,614) 19,499 / (19,499) 1,453 / 1,453 Increase / (decrease) in EUR/CHF exchange rate by 10% (94) / 94 648 / (648) 836 / (836) Increase / (decrease) in GBP/CHF exchange rate by 10% (83) / 83 (18) / 18 351 / (351)) Increase / (decrease) in USD/EUR exchange rate by 10% 503 / (503) 726 / (726) 155 / (155)
Sensitivity of Equity to Changes in Foreign Exchange Rates	As of December 31, 2022 and 2021 the sensitivity of the Company’s equity to such changes, measured against the USD, was as follows (in USD thousands): December 31, 2022 2021 Increase / (decrease) in USD/CHF exchange rate by 10% 14,198 / (14,198) 54 / (54) Increase / (decrease) in USD/EUR exchange rate by 10% (44) / 44 (89) / 89 Increase / (decrease) in USD/GBP exchange rate by 10% 50 / (50) (27) / 27 Increase / (decrease) in USD/BRL exchange rate by 10% 133 / (133) 77 / (77)

Company information and opera_3

Company information and operations - Summary of Wholly-Owned Subsidiaries (Details)	12 Months Ended
	Dec. 31, 2022
SOPHiA GENETICS S.A.S.
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS S.A.S.
Country of domicile	France
SOPHiA GENETICS LTD
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS LTD
Country of domicile	UK
SOPHiA GENETICS, Inc.
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS, Inc.
Country of domicile	USA
SOPHiA GENETICS Intermediação de Negócios LTDA
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS Intermediação de Negócios LTDA
Country of domicile	Brazil
SOPHiA GENETICS PTY LTD
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS PTY LTD
Country of domicile	Australia
SOPHiA GENETICS S.R.L.
Disclosure Of Significant Investments In Subsidiaries [Line Items]
Name	SOPHiA GENETICS S.R.L.
Country of domicile	Italy

Company information and opera_4

Company information and operations - Additional Information (Details) $ / shares in Units, $ in Millions				3 Months Ended	12 Months Ended
	Aug. 25, 2021 USD ($) $ / shares shares	Jul. 27, 2021 USD ($) $ / shares shares	Jun. 30, 2021	Mar. 31, 2022 shares	Dec. 31, 2022 $ / shares shares	Dec. 31, 2022 SFr / shares shares	Dec. 31, 2021 shares	Aug. 25, 2021 SFr / shares shares	Jul. 27, 2021 SFr / shares shares	Dec. 31, 2020 shares	Dec. 31, 2019 shares
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)							63,857,604
Share split ratio			0.05
Share capital
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)					66,398,164	66,398,164	63,857,604			47,955,700	38,319,760
Number of shares outstanding (in shares)					64,231,220	64,231,220
Issuance of shares to be held as treasury shares (in shares)				2,540,560	2,540,560
Treasury Share capital
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)					2,166,944	2,166,944	0			0	0
Issuance of shares to be held as treasury shares (in shares)					2,540,560
Ordinary Shares
Disclosure Of Company Information And Operations [Line Items]
Shares issued, par value (in dollars per share) | (per share)					$ 0.05	SFr 0.05
Initial Public Offering | Ordinary Shares
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)	13,519,493	13,000,000						13,519,493	13,000,000
Shares price per share (in dollars per share) | $ / shares		$ 18
Shares issued, par value (in dollars per share) | (per share)		$ 0.05							SFr 0.05
Net proceeds from IPO | $		$ 211.7
Preferred stock conversion ratio	1							1
Preferred shares were converted into ordinary shares (in shares)		24,561,200							24,561,200
Private Placement | Ordinary Shares
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)		1,111,111							1,111,111
Shares price per share (in dollars per share) | $ / shares		$ 18
Shares issued, par value (in dollars per share) | (per share)		$ 0.05							SFr 0.05
Net proceeds from IPO | $		$ 19.6
Underwriters | Ordinary Shares
Disclosure Of Company Information And Operations [Line Items]
Number of shares issued (in shares)	519,493							519,493
Shares price per share (in dollars per share) | $ / shares	$ 18
Shares issued, par value (in dollars per share) | (per share)	$ 0.05							SFr 0.05
Net proceeds from IPO | $	$ 9.4
Net proceeds from issuance | $	$ 8.5

Segment reporting (Details)

Segment reporting (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Operating Segments [Line Items]
Total non-current assets other than financial instruments and deferred tax assets	$ 41,359	$ 31,628
Switzerland
Disclosure Of Operating Segments [Line Items]
Total non-current assets other than financial instruments and deferred tax assets	39,052	28,973
France
Disclosure Of Operating Segments [Line Items]
Total non-current assets other than financial instruments and deferred tax assets	498	290
United States
Disclosure Of Operating Segments [Line Items]
Total non-current assets other than financial instruments and deferred tax assets	1,803	2,357
Brazil
Disclosure Of Operating Segments [Line Items]
Total non-current assets other than financial instruments and deferred tax assets	$ 6	$ 8

Revenue - Additional Informatio

Revenue - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Performance Obligations [Line Items]
Accrued contract revenue	$ 1,500,000	$ 700,000
Loss allowance related to accrued contract revenue	0	0
Deferred contract revenue brought forward	4,000,000	2,900,000
Deferred contract revenue recognized	$ 4,000,000	2,900,000
Maximum
Disclosure Of Performance Obligations [Line Items]
Term of payment agreements for products and services sold	180 days
Workflow equipment and services
Disclosure Of Performance Obligations [Line Items]
Revenues from payments from leased equipment recognized	$ 100,000	$ 200,000	$ 100,000

Revenue - Schedule of Revenue f

Revenue - Schedule of Revenue from Contracts with Customers Allocated to Geographical Areas and Revenue Streams (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	$ 47,560	$ 40,450	$ 28,400
SOPHiA DDM Platform
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	45,679	39,465	27,221
Workflow equipment and services
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	1,881	985	1,179
EMEA
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	34,878	31,583	22,073
NORAM
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	6,732	4,730	2,923
LATAM
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	3,003	2,295	2,131
APAC
Disclosure Of Disaggregation Of Revenue From Contracts With Customers [Line Items]
Total revenue	$ 2,947	$ 1,842	$ 1,273

Operating expense - Additional

Operating expense - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Research tax credit	$ 1,292	$ 1,597	$ 763
Research and Development and Innovation
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Research tax credit	$ 1,300	$ 1,600	$ 800

Operating expense - Summary of

Operating expense - Summary of Operating Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Analysis of income and expense [abstract]
Changes in inventories of finished goods and work in progress	$ 47	$ 568	$ (259)
Raw materials and consumables used	(13,341)	(9,650)	(3,843)
Employee benefit expenses	(59,333)	(53,802)	(36,732)
Social charges	(11,480)	(8,373)	(6,983)
COVID—salaries reimbursement	0	0	1,129
Research tax credit	1,292	1,597	763
Share-based compensation	(13,613)	(8,514)	(1,359)
Depreciation	(3,791)	(2,517)	(1,758)
Amortization	(1,780)	(1,092)	(632)
Professional fees	(13,837)	(11,318)	(5,371)
Office expenses	(6,635)	(5,333)	(2,006)
Travel	(3,217)	(1,576)	(1,361)
Marketing	(2,213)	(1,493)	(972)
Licenses	(3,949)	(2,021)	(1,647)
Less: capitalized software development costs ("Note 17 - Intangible assets”)	5,820	3,858	2,436
Other expense	(9,730)	(12,381)	(7,099)
Total	$ (135,760)	$ (112,047)	$ (65,694)

Operating expense - Summary o_2

Operating expense - Summary of Depreciation and Amortization have Charged in Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Depreciation	$ (3,791)	$ (2,517)	$ (1,758)
Amortization	(1,780)	(1,092)	(632)
Cost of revenue
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Depreciation	0	0	0
Amortization	(1,133)	(483)	(111)
Research and development costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Depreciation	(1,748)	(1,028)	(727)
Amortization	0	0	0
Selling and marketing costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Depreciation	(906)	(744)	(543)
Amortization	0	0	0
General and administrative costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Depreciation	(1,137)	(745)	(488)
Amortization	$ (647)	$ (609)	$ (521)

Operating expense - Summary o_3

Operating expense - Summary of Employee Benefit Expenses, Social Charges and Share-based Compensation from the Operating Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Total	$ 84,426	$ 70,689	$ 45,074
Research and development costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Total	29,169	23,899	16,109
Selling and marketing costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Total	20,216	21,659	12,085
General and administrative costs
Disclosure Of Attribution Of Expenses By Nature To Their Function [Line Items]
Total	$ 35,041	$ 25,131	$ 16,880

Finance income (expense), net_2

Finance income (expense), net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Finance Expense Net [Abstract]
Interest income	$ 1,324	$ 20	$ 96
Total interest income	1,324	20	96
Interest on loans	0	(120)	(513)
Interest on lease liabilities	(422)	(225)	(121)
Other interest	(217)	(313)	(206)
Total interest expense	(639)	(658)	(840)
Derivative fair value (losses)	0	(1,444)	(384)
Foreign exchange gains (losses), net	(447)	64	(2,710)
Total finance income (expense), net	$ 238	$ (2,018)	$ (3,838)

Income tax - Additional Informa

Income tax - Additional Information (Details) - USD ($) $ in Millions	1 Months Ended	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2022	Dec. 31, 2021
Current income tax expense
Unrecognized tax liability including interest and penalties	$ 0.3	$ 0.3	$ 0.1
French subsidiary
Current income tax expense
Dividends payments received		$ 3.4
Net operating loss carryforward | France
Current income tax expense
Decrease in tax loss carryforwards	1.8
Decrease in tax effected amount of tax loss carryforwards	$ (0.5)

Income tax - Summary of Current

Income tax - Summary of Current and Deferred Tax (Expenses) Benefits (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Current income tax expense
Current tax expense (income)	$ (310)	$ 0	$ 0
Uncertain tax positions	328	(110)	(74)
Total current income tax expense	18	(110)	(74)
Deferred income tax (expense) benefit
Origination and reversal of temporary differences	118	(58)	1,960
Total deferred income tax (expense) benefit	118	(58)	1,960
Total income tax (expense) benefit	$ 136	$ (168)	$ 1,886

Income tax - Reconciliation of

Income tax - Reconciliation of Expected Tax Expense to Tax Expense Report in Statement of Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Major components of tax expense (income) [abstract]
Loss before tax	$ (87,585)	$ (73,507)	$ (41,225)
Tax at Swiss statutory rate	11,749	9,907	5,541
Effect of tax rates in foreign jurisdictions	(292)	(218)	(177)
Unrecognized deferred tax assets	(9,386)	(9,077)	(3,276)
Income not subject to tax (expense not deductible for tax purposes)	(1,940)	(805)	41
Uncertain tax positions	328	(110)	(74)
Recognition of deferred tax assets from previously unrecognized tax assets	509	0	0
2018-2019 French tax assessment	(427)	0	0
Other	(405)	135	(169)
Total income tax (expense) benefit	$ 136	$ (168)	$ 1,886

Income tax - Summary of Movemen

Income tax - Summary of Movement in Deferred Tax Balances (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	$ 1,990	$ 2,114
Recognized in profit or loss	117	(58)
Recognized in OCI	(59)
Currency translation differences	(108)	(66)
Deferred tax liability (asset) at end of period	1,940	1,990
Deferred tax assets	2,410	2,636
Deferred tax liabilities	(470)	(646)
Depreciation & amortization
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	(29)	288
Recognized in profit or loss	(50)	(309)
Recognized in OCI	0
Currency translation differences	(1)	(8)
Deferred tax liability (asset) at end of period	(80)	(29)
Deferred tax assets		0
Deferred tax liabilities	(80)	(29)
Bad debt reserves
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	341	433
Recognized in profit or loss	(324)	(65)
Recognized in OCI	0
Currency translation differences	(17)	(27)
Deferred tax liability (asset) at end of period	0	341
Deferred tax assets		341
Deferred tax liabilities	0	0
Accrued pension
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	44	35
Recognized in profit or loss	26	12
Recognized in OCI	(59)
Currency translation differences	(2)	(3)
Deferred tax liability (asset) at end of period	9	44
Deferred tax assets	9	44
Deferred tax liabilities	0	0
ROU asset
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	(352)	(311)
Recognized in profit or loss	60	(34)
Recognized in OCI	0
Currency translation differences	(10)	(7)
Deferred tax liability (asset) at end of period	(302)	(352)
Deferred tax assets		0
Deferred tax liabilities	(302)	(352)
Lease liability
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	630	301
Recognized in profit or loss	(119)	331
Recognized in OCI	0
Currency translation differences		(2)
Deferred tax liability (asset) at end of period	511	630
Deferred tax assets	511	630
Deferred tax liabilities	0	0
Other
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	96	(10)
Recognized in profit or loss	725	38
Recognized in OCI	0
Currency translation differences	31	68
Deferred tax liability (asset) at end of period	852	96
Deferred tax assets	940	361
Deferred tax liabilities	(88)	(265)
Net operating loss carryforward
Reconciliation Of Changes In Deferred Tax Liability (Asset) [Abstract]
Deferred tax liability (asset) at beginning of period	1,260	1,378
Recognized in profit or loss	(201)	(31)
Recognized in OCI	0
Currency translation differences	(109)	(87)
Deferred tax liability (asset) at end of period	950	1,260
Deferred tax assets	950	1,260
Deferred tax liabilities	$ 0	$ 0

Income tax - Summary of Unrecog

Income tax - Summary of Unrecognized Deferred Tax Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Current income tax expense
Gross amount	$ 266,871	$ 207,495
Tax effect	34,735	29,326
Deductible temporary differences
Current income tax expense
Gross amount	3,385	5,101
Tax effect	511	729
Net operating loss carryforward
Current income tax expense
Gross amount	263,486	202,394
Tax effect	$ 34,224	$ 28,597

Income tax - Summary of Net Ope

Income tax - Summary of Net Operating Loss Carryforwards (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Major components of tax expense (income) [abstract]
One year	$ 12,007	$ 7,625
Two years	16,261	12,170
Three years	15,561	16,482
Four years	23,515	15,772
Thereafter and unlimited	196,142	150,345
Net operating loss carryforwards	$ 263,486	$ 202,394

Loss per share - Additional inf

Loss per share - Additional information (Details) - Dec. 31, 2022	$ / shares	SFr / shares
Ordinary Shares
Earnings Per Share [Line Items]
Nominal value (in dollars per share) | (per share)	$ 0.05	SFr 0.05

Loss per share - Components of

Loss per share - Components of Loss for Year (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Earnings per share [abstract]
Net loss attributed to shareholders	$ (87,449)	$ (73,675)	$ (39,339)
Weighted average number of shares in issue, basic (in shares)	64,099,213	55,299,863	42,350,757
Weighted average number of shares in issue, diluted (in shares)	64,099,213	55,299,863	42,350,757
Basic loss per share (in dollars per share)	$ (1.36)	$ (1.33)	$ (0.93)
Diluted loss per share (in dollars per share)	$ (1.36)	$ (1.33)	$ (0.93)

Cash and cash equivalents - Sch

Cash and cash equivalents - Schedule of Cash and Cash Equivalents (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Cash and cash equivalents [abstract]
Cash	$ 25,820	$ 39,578
Cash equivalents	135,485	153,384
Cash and cash equivalents	$ 161,305	$ 192,962	$ 74,625	$ 18,069

Cash and cash equivalents - Add

Cash and cash equivalents - Additional Information (Details) $ in Millions	Jul. 31, 2021 USD ($)
Cash and cash equivalents [abstract]
Cash designated to separate bank accounts	$ 30

Term deposits (Details)

Term deposits (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Term Deposits [Abstract]
Term deposits, over 3 months, up to 12 months	$ 17,307	$ 72,357
Total term deposits	$ 17,307	$ 72,357

Accounts receivable - Additiona

Accounts receivable - Additional Information (Detail) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Trade and other receivables [abstract]
Accounts receivable balance non-interest bearing and payment terms	180 days
Percentage of customer balance account receivable	15%	18%
Accounts receivable in aggregate amount	$ 5,400,000	$ 4,600,000
Long-term lease receivables	0	0
Net lease receivables	$ 200,000	$ 200,000

Accounts receivable - Schedule

Accounts receivable - Schedule of Accounts Receivable and Lease Receivable Less Expected Credit Loss (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Trade and other receivables [abstract]
Accounts receivable	$ 6,060	$ 7,060
Accrued contract revenue	1,499	657
Lease receivable	185	237
Allowance for expected credit losses	(1,095)	(1,676)	$ (2,664)
Net accounts receivable	$ 6,649	$ 6,278

Accounts receivable - Schedul_2

Accounts receivable - Schedule of Movement in Allowance for Expected Credit Losses in Accounts Receivable (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation of changes in allowance account for credit losses of financial assets [abstract]
Balance at beginning of period	$ 1,676	$ 2,664
Increase	404	1,273
Reversals	(804)	(1,612)
Write-off	(67)	(572)
Currency translation differences	(114)	(77)
Balance at end of period	$ 1,095	$ 1,676

Inventory - Schedule of Invento

Inventory - Schedule of Inventory (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Classes of current inventories [abstract]
Raw materials	$ 5,195	$ 5,105
Work in progress	1,340	1,330
Finished goods	124	87
Provision	(1,503)	(793)	$ (713)
Total	$ 5,156	$ 5,729

Inventory - Schedule of Inven_2

Inventory - Schedule of Inventory Provision Movement (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation Of Changes In Provision Of Inventory [Abstract]
Balance at beginning of period	$ (793)	$ (713)
Increase in provision	(697)	(105)
Currency Translation Adjustment	(13)	25
Balance at end of period	$ (1,503)	$ (793)

Prepaids and other current as_3

Prepaids and other current assets (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Prepaids And Other Current Assets [Abstract]
Deferred contract costs	$ 0	$ 150
Prepayments	3,703	3,943
VAT receivable	1,244	811
Government grants receivable	160	0
Other	731	625
Total	$ 5,838	$ 5,529

Property and equipment - Additi

Property and equipment - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Property Plant And Equipment [Line Items]
Accrued expenses	$ 0.1	$ 0.5
Computer hardware | Minimum
Disclosure Of Property Plant And Equipment [Line Items]
Useful life of property and equipment	3 years
Computer hardware | Maximum
Disclosure Of Property Plant And Equipment [Line Items]
Useful life of property and equipment	5 years
Machinery and equipment
Disclosure Of Property Plant And Equipment [Line Items]
Useful life of property and equipment	5 years
Furniture and fixtures
Disclosure Of Property Plant And Equipment [Line Items]
Useful life of property and equipment	5 years

Property and equipment - Summar

Property and equipment - Summary of Property and Equipment, Net (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	$ 4,663
Balance at end of period	7,129	$ 4,663
Gross Carrying Amount
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	7,238	3,927
Additions	3,744	3,896
Disposals	(432)	(459)
Currency Translation Adjustment	(1)	(126)
Balance at end of period	10,549	7,238
Accumulated depreciation
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	(2,575)	(2,155)
Additions	(1,291)	(942)
Disposals	432	437
Currency Translation Adjustment	14	85
Balance at end of period	(3,420)	(2,575)
Leasehold improvements
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	2,690
Balance at end of period	5,017	2,690
Leasehold improvements | Gross Carrying Amount
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	3,260	890
Additions	2,895	2,447
Disposals	0	(49)
Currency Translation Adjustment	27	(28)
Balance at end of period	6,182	3,260
Leasehold improvements | Accumulated depreciation
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	(570)	(258)
Additions	(588)	(352)
Disposals	0	29
Currency Translation Adjustment	(7)	11
Balance at end of period	(1,165)	(570)
Machinery and equipment
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	698
Balance at end of period	961	698
Machinery and equipment | Gross Carrying Amount
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	1,116	615
Additions	480	608
Disposals	0	(85)
Currency Translation Adjustment	30	(22)
Balance at end of period	1,626	1,116
Machinery and equipment | Accumulated depreciation
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	(418)	(398)
Additions	(224)	(119)
Disposals	0	85
Currency Translation Adjustment	(23)	14
Balance at end of period	(665)	(418)
Computer hardware
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	627
Balance at end of period	490	627
Computer hardware | Gross Carrying Amount
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	1,855	1,799
Additions	147	421
Disposals	(319)	(294)
Currency Translation Adjustment	(50)	(71)
Balance at end of period	1,633	1,855
Computer hardware | Accumulated depreciation
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	(1,228)	(1,230)
Additions	(273)	(341)
Disposals	319	292
Currency Translation Adjustment	39	51
Balance at end of period	(1,143)	(1,228)
Furniture and fixtures
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	648
Balance at end of period	661	648
Furniture and fixtures | Gross Carrying Amount
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	1,007	623
Additions	222	420
Disposals	(113)	(31)
Currency Translation Adjustment	(8)	(5)
Balance at end of period	1,108	1,007
Furniture and fixtures | Accumulated depreciation
Reconciliation of changes in property, plant and equipment [abstract]
Balance at beginning of period	(359)	(269)
Additions	(206)	(130)
Disposals	113	31
Currency Translation Adjustment	5	9
Balance at end of period	$ (447)	$ (359)

Intangible Assets - Additional

Intangible Assets - Additional Information (Details)		12 Months Ended
	Oct. 01, 2022	Dec. 31, 2022 USD ($) segment	Dec. 31, 2021 USD ($)	Oct. 01, 2021 USD ($)
Schedule Of Intangible Assets [Line Items]
Operating segment | segment		1
Goodwill impairment		$ 0	$ 0
Estimated equity value				$ 1,200,500,000
Exceeds the reported net assets				289,700,000
Equity value				$ 910,800,000
CGU valuation, discounted cash flow forecast period	7 years
CGU valuation, WACC rate	0.12
CGU valuation, terminal free cash flow rate	0.03
Sensitivity analysis, WAAC rate at which impairment of CGU would occur	0.20
Projected revenue period	7 years
Projected revenue CAGR	0.37
Sensitivity analysis, CAGR rate at which impairment of CGU would occur	0.25
Sensitivity analysis, period at identified CAGR rate at which impairment of CGU would occur	7 years
Purchased software
Schedule Of Intangible Assets [Line Items]
Estimated life		5 years
Capitalized internally developed software costs
Schedule Of Intangible Assets [Line Items]
Estimated life		5 years

Intangible Assets - Intangible

Intangible Assets - Intangible Assets Net, Movement (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	$ 15,673
Ending balance	19,963	$ 15,673
Gross Carrying Amount
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	17,747	14,290
Additions	6,284	3,988
Disposals	(80)	(30)
Currency Translation Adjustment	(42)	(501)
Ending balance	23,909	17,747
Accumulated amortization
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	(2,074)	(1,008)
Additions	(1,780)	(1,092)
Disposals	7
Currency Translation Adjustment	(99)	26
Ending balance	(3,946)	(2,074)
Goodwill
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	8,298
Ending balance	8,188	8,298
Goodwill | Gross Carrying Amount
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	8,298	8,598
Additions	0	0
Disposals	0	0
Currency Translation Adjustment	(110)	(300)
Ending balance	8,188	8,298
Goodwill | Accumulated amortization
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	0	0
Additions	0	0
Disposals	0
Currency Translation Adjustment	0	0
Ending balance	0	0
Purchased software
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	1,658
Ending balance	1,478	1,658
Purchased software | Gross Carrying Amount
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	3,090	3,071
Additions	464	130
Disposals	0	0
Currency Translation Adjustment	(24)	(111)
Ending balance	3,530	3,090
Purchased software | Accumulated amortization
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	(1,432)	(889)
Additions	(618)	(565)
Disposals	0
Currency Translation Adjustment	(2)	22
Ending balance	(2,052)	(1,432)
Capitalized internally developed software costs
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	5,717
Ending balance	10,297	5,717
Capitalized internally developed software costs | Gross Carrying Amount
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	6,359	2,621
Additions	5,820	3,858
Disposals	(80)	(30)
Currency Translation Adjustment	92	(90)
Ending balance	12,191	6,359
Capitalized internally developed software costs | Accumulated amortization
Reconciliation of changes in intangible assets other than goodwill [abstract]
Beginning balance	(642)	(119)
Additions	(1,162)	(527)
Disposals	7
Currency Translation Adjustment	(97)	4
Ending balance	$ (1,894)	$ (642)

Leases - Additional Information

Leases - Additional Information (Details) $ in Thousands							12 Months Ended
	Jan. 01, 2023 ft²	Jan. 25, 2022 USD ($) ft²	Jan. 01, 2022 ft²	Aug. 09, 2021 ft²	Jul. 01, 2021 ft²	Mar. 03, 2021 ft²	Dec. 31, 2022 USD ($) Lease	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Disclosure Of Lease [Line Items]
Number of significant leases | Lease							1
Right-of-use assets							$ 14,268	$ 11,292	$ 3,767
Lease liabilities							16,743	13,059	$ 3,919
Lease expenses							$ 200	$ 300
Right-of-use assets discounted payments rate							2.61%	2.61%
Lease liabilities discounted payments rate							3.47%	3.47%
Consumer Price Indices in Switzerland and France
Disclosure Of Lease [Line Items]
Lease liabilities							$ 14,700	$ 10,800
Minimum
Disclosure Of Lease [Line Items]
Lease terms for office buildings							1 year
Cash outflows related to leases less than 12 months							$ 200	300
Maximum
Disclosure Of Lease [Line Items]
Lease terms for office buildings							10 years
Office Space | Rolle
Disclosure Of Lease [Line Items]
Lease term						120 months
Area of office space leased (in sq ft) | ft²						65,860
Area of office space gained access under lease (in sq ft) | ft²		21,258	7,535		11,840
Expected lease commitments							$ 500	$ 100
Right-of-use assets		$ 4,500					7,700
Lease liabilities		$ 4,500					8,500
Lease incentives and expected restoration costs							800
Office Space | Rolle | Year 2023
Disclosure Of Lease [Line Items]
Expected lease commitments							1,000
Office Space | Rolle | Year 2024
Disclosure Of Lease [Line Items]
Expected lease commitments							1,140
Office Space | Rolle | Amendment to Lease
Disclosure Of Lease [Line Items]
Area of office space gained access under lease (in sq ft) | ft²	21,258
Office Space | Boston
Disclosure Of Lease [Line Items]
Lease term				40 months
Area of office space leased (in sq ft) | ft²				9,192
Expected lease commitments							500
Right-of-use assets							1,200
Lease liabilities							1,400
Lease incentives and expected restoration costs							$ 200

Leases - Schedule of Movements

Leases - Schedule of Movements in Right of Use Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation Of Changes In Right-Of-Use Assets [Abstract]
Balance at beginning of period	$ 11,292	$ 3,767
Additions	5,388	9,205
Depreciation charge	(2,500)	(1,575)
Currency translation effects	88	(105)
Balance at end of period	$ 14,268	$ 11,292

Leases - Schedule of Movement_2

Leases - Schedule of Movements in Lease Liabilities (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Reconciliation Of Changes In Lease Liabilities [Abstract]
Balance at beginning of period	$ 13,059	$ 3,919
Additions	5,441	10,165
Cash outflows (principle and interest)	(2,316)	(1,143)
Non-cash interest	422	225
Currency translation effects	137	(107)
Balance at end of period	$ 16,743	$ 13,059

Accounts payable (Details)

Accounts payable (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Subclassifications of assets, liabilities and equities [abstract]
Trade payables	$ 2,170	$ 2,337
Employee related payables	3,655	3,509
VAT and sales taxes	356	891
Total	$ 6,181	$ 6,737

Accrued expenses (Details)

Accrued expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Accrued Expenses [Abstract]
Accrued Compensation	$ 10,268	$ 9,148
Accrued Professional fees	2,162	2,743
Accrued inventory purchases	315	2,472
Accrued IT support	22	25
Accrued Legal fees	287	125
Accrued Other	1,451	1,459
Total	$ 14,505	$ 15,972

Other non-current assets (Detai

Other non-current assets (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Miscellaneous non-current assets [abstract]
Research tax credit receivable	$ 3,342	$ 2,295
Guarantee deposit	941	1,405
Other non-current assets	$ 4,283	$ 3,700

Post-employment benefits - Summ

Post-employment benefits - Summary of Additional Details on Defined Pension Plans Funded Status (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Information About Post Employment Benefits [Abstract]
Present value of defined benefit obligation	$ (19,252)	$ (17,889)	$ (15,938)
Fair value of plan assets	16,577	13,436
Net pension liability	$ 2,675	$ 4,453

Post-employment benefits - Su_2

Post-employment benefits - Summary of Movement in Defined Benefit Obligation (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Reconciliation Of Changes In Defined Benefit Obligation [Abstract]
January 1	$ (17,889)	$ (15,938)
Service Cost	(1,849)	(1,134)	$ (1,596)
of which current service cost	(1,963)	(1,462)
of which past service cost	114	328
Interest expense	(156)	(50)	(7)
Actuarial gains (losses)	2,360	497	214
Actual plan participants’ contributions	(1,361)	(1,171)
Transfers (in) out due to (joiners) leavers	(551)	(651)
Currency translation differences	194	558
December 31	(19,252)	(17,889)	(15,938)
Funded
Reconciliation Of Changes In Defined Benefit Obligation [Abstract]
January 1	(17,686)	(15,773)
Service Cost	(1,759)	(1,054)	(1,547)
of which current service cost	(1,873)	(1,382)
of which past service cost	114	328
Interest expense	(154)	(49)	(6)
Actuarial gains (losses)	2,110	471	244
Actual plan participants’ contributions	(1,361)	(1,171)
Transfers (in) out due to (joiners) leavers	(551)	(651)
Currency translation differences	180	541
December 31	(19,221)	(17,686)	(15,773)
Unfunded
Reconciliation Of Changes In Defined Benefit Obligation [Abstract]
January 1	(203)	(165)
Service Cost	(90)	(80)	(49)
of which current service cost	(90)	(80)
of which past service cost	0	0
Interest expense	(2)	(1)	(1)
Actuarial gains (losses)	250	26	(30)
Actual plan participants’ contributions	0	0
Transfers (in) out due to (joiners) leavers	0	0
Currency translation differences	14	17
December 31	$ (31)	$ (203)	$ (165)

Post-employment benefits - Addi

Post-employment benefits - Additional Information (Details) $ in Millions	12 Months Ended
	Dec. 31, 2022 USD ($) Member	Dec. 31, 2021 USD ($) Member
Disclosure Of Defined Benefit Plans [Line Items]
Past service cost gain	$ 0.1
Demographic assumptions increase in expected employee salaries	3%	1.25%
Demographic assumptions increase in expected employee turnover rate	1.25%	1%
Average life expectancy in years after retirement for male	22 years 8 months 12 days	22 years 5 months 23 days
Average life expectancy in years after retirement for female	22 years 6 months 25 days	24 years 4 months 13 days
United States
Disclosure Of Defined Benefit Plans [Line Items]
Post-employment benefit expense, 401(k) defined contribution plan	$ 0.4
United States | Maximum
Disclosure Of Defined Benefit Plans [Line Items]
Post-employment benefit expense, 401(k) defined contribution plan		$ 0.2
Swiss Pension Plan
Disclosure Of Defined Benefit Plans [Line Items]
Number of active members | Member	248	252
Demographic assumptions increase in expected employee salaries	3%	1.25%
Demographic assumptions increase in expected employee turnover rate	1.50%	0.75%
Estimating the defined benefit obligation, the discount rates	2.25%	0.30%
Weighted average modified duration	13 years 2 months 12 days	15 years 10 months 24 days
LPP interest rate	2.25%	1%
Extra mandatory part equivalent to discount rate	2.25%	0.30%
Expected employer contributions for next annual reporting period	$ 1.5
French Pension Plan
Disclosure Of Defined Benefit Plans [Line Items]
Number of active members | Member	102	105
Demographic assumptions increase in expected employee salaries	3%	2.50%
Estimating the defined benefit obligation, the discount rates	3.90%	1.20%
Weighted average modified duration	16 years	25 years 10 months 24 days

Post-employment benefits - Su_3

Post-employment benefits - Summary of Movement in Defined Benefit Plans Assets (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Reconciliation Of Changes In Net Defined Benefit Liability (Asset) [Abstract]
Balance at beginning of period	$ 13,436	$ 10,780
Interest income	125	39
Return on plan assets, excl. interest income	(204)	(32)	$ (45)
Administrative expenses	(71)	(62)
Employer contributions	1,452	1,257
Employee contributions	1,361	1,171
Transfers in (out) due to joiners (leavers)	551	651
Currency translation differences	(73)	(368)
Balance at end of period	$ 16,577	$ 13,436	$ 10,780

Post-employment benefits - Su_4

Post-employment benefits - Summary of Defined Benefit Plans Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Information About Post Employment Benefits [Abstract]
Cash	$ 664	$ 528
Insurance policies	15,913	12,908
Total	$ 16,577	$ 13,436	$ 10,780

Post-employment benefits - Sche

Post-employment benefits - Schedule of Pension Costs Recognized in Statement of Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Defined Benefit Plans [Line Items]
Service Cost	$ (1,849)	$ (1,134)	$ (1,596)
Interest cost	(156)	(50)	(7)
Total recognized	(2,005)	(1,184)	(1,603)
Funded
Disclosure Of Defined Benefit Plans [Line Items]
Service Cost	(1,759)	(1,054)	(1,547)
Interest cost	(154)	(49)	(6)
Total recognized	(1,913)	(1,103)	(1,553)
Unfunded
Disclosure Of Defined Benefit Plans [Line Items]
Service Cost	(90)	(80)	(49)
Interest cost	(2)	(1)	(1)
Total recognized	$ (92)	$ (81)	$ (50)

Post-employment benefits - Sc_2

Post-employment benefits - Schedule of Pension Remeasurement Recognized in Statement Other Comprehensive Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Defined Benefit Plans [Line Items]
Changes in demographic assumptions	$ 223	$ 1,278	$ 1,039
Changes in financial assumptions	2,323	50	141
Experience adjustments	(186)	(831)	(966)
Total actuarial gains (losses)	2,360	497	214
Return on plan assets	(204)	(32)	(45)
Currency translation differences	(2)	(4)	15
Total recognized	2,154	461	184
Funded
Disclosure Of Defined Benefit Plans [Line Items]
Changes in demographic assumptions	0	1,278	1,039
Changes in financial assumptions	2,311	37	157
Experience adjustments	(201)	(844)	(952)
Total actuarial gains (losses)	2,110	471	244
Return on plan assets	(204)	(32)	(45)
Currency translation differences	(4)	(4)	13
Total recognized	1,902	435	212
Unfunded
Disclosure Of Defined Benefit Plans [Line Items]
Changes in demographic assumptions	223	0	0
Changes in financial assumptions	12	13	(16)
Experience adjustments	15	13	(14)
Total actuarial gains (losses)	250	26	(30)
Return on plan assets	0	0	0
Currency translation differences	2	0	2
Total recognized	$ 252	$ 26	$ (28)

Post-employment benefits - Sc_3

Post-employment benefits - Schedule of Sensitivity Analysis for Funded Plans (Details) - Funded - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Discount rates
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 25 basis points	$ (426)	$ (576)
Decrease of 25 basis points	467	635
Expected rates of salary increases
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 25 basis points	110	122
Decrease of 25 basis points	(107)	(120)
Interest rate
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 25 basis points	150	189
Decrease of 25 basis points	(146)	(185)
Inflation
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 25 basis points	102	121
Decrease of 25 basis points	(99)	(118)
Life expectancy
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 25 basis points	71	145
Decrease of 25 basis points	$ (71)	$ (145)

Post-employment benefits - Sc_4

Post-employment benefits - Schedule of Sensitivity Analysis for Unfunded Plans (Details) - Unfunded - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Discount rates
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 50 basis points	$ (2)	$ (26)
Decrease of 50 basis points	2	30
Expected rates of salary increases
Disclosure Of Sensitivity Analysis For Actuarial Assumptions [Line Items]
Increase of 50 basis points	3	30
Decrease of 50 basis points	$ (2)	$ (26)

Share-based compensation - Addi

Share-based compensation - Additional Information (Details) $ / shares in Units, $ in Thousands						9 Months Ended	12 Months Ended			36 Months Ended
	Jul. 27, 2021 USD ($)	Apr. 22, 2021	Mar. 25, 2021 USD ($) year $ / shares	Mar. 25, 2021 USD ($) SFr / shares	Nov. 29, 2018 USD ($) shares	Jan. 19, 2022 shares	Dec. 31, 2022 USD ($) shares year plan $ / shares	Dec. 31, 2021 USD ($) shares $ / shares	Dec. 31, 2020 USD ($)	Dec. 31, 2022 shares
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Number of share option plans | plan							3
Expense recognized | $	$ 300						$ 13,613	$ 8,514	$ 1,359
CEO
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Number of share options granted (in shares)					300,000
Strike price (in dollars per share) | (per share)			$ 3.33	SFr 3.15
Expected life of share options (years) | year			5
Value of award | $			$ 300	SFr 300
Expense recognized | $			300
Minimum | CEO
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Net proceeds from IPO | $			$ 1,000,000		$ 1,000,000
2013 ISOP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Number of share options granted (in shares)										0
Vesting percentage on second anniversary of grant date							0.50
Vesting percentage on third anniversary							0.50
Share options exercised (in shares)							193,560	892,020
Weighted average share price at date of exercise (in dollars per share) | $ / shares							$ 7.41	$ 13.84
Expected life of share options (years) | year							10
2019 ISOP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Number of share options granted (in shares)							0	1,369,000
Vesting percentage on each anniversary over four year							0.25
Vesting period on each anniversary							4 years
Vesting period of unvested options in event of IPO or public listing		6 months
Share options exercised (in shares)						0	135,984	379,250
Additional expense incurred | $								$ 200
Weighted average share price at date of exercise (in dollars per share) | $ / shares							$ 6.19	$ 13.84
2019 ISOP | Minimum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Expected life of share options (years)								6.05	5.67
2021 EIP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Number of share options granted (in shares)							1,336,284	1,595,314
Vesting percentage on first anniversary on grant date							0.25
Vesting percentage on monthly basis over remaining three years							0.75
Vesting period on monthly basis							3 years
Share options exercised (in shares)							0	0
2021 EIP | Restricted Stock Units
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Vesting percentage on first anniversary on grant date							0.25
Vesting percentage on monthly basis over remaining three years							0.75
Number of share issuance (in shares)							1,776,832
Number of instruments granted subject to four year vesting (in shares)							1,396,366
RSU vesting period							4 years
RSU vesting period on monthly basis							3 years
Number of instruments granted subject to vesting upon annual general meeting (in shares)							380,466
2021 EIP | Minimum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Expected life of share options (years)							5.50	5.50

Share-based compensation - Summ

Share-based compensation - Summary of Stock Option Activity (Details)	9 Months Ended	12 Months Ended			36 Months Ended
	Jan. 19, 2022 shares	Dec. 31, 2022 shares $ / shares	Dec. 31, 2021 shares $ / shares	Dec. 31, 2020 shares $ / shares	Dec. 31, 2022 shares $ / shares
2013 ISOP
Number of options
Outstanding at beginning of period (in shares)		859,540	1,751,560
Granted (in shares)					0
Forfeited (in shares)		(8,000)
Exercised (in shares)		(193,560)	(892,020)
Outstanding at end of period (in shares)		657,980	859,540	1,751,560	657,980
Exercisable (in shares)		657,980	849,540		657,980
Weighted average exercise price
Outstanding at beginning of period (in dollars per share) | $ / shares		$ 2.75	$ 3.10
Forfeited (in dollars per share) | $ / shares		3.19
Exercised (in dollars per share) | $ / shares		2.44	3
Outstanding at end of period (in dollars per share) | $ / shares		2.92	2.75	$ 3.10	$ 2.92
Exercisable (in dollars per share) | $ / shares		$ 2.92	$ 2.75		$ 2.92
Weighted average remaining life in years
Outstanding		4 years 2 months 26 days	5 years 29 days	6 years 4 months 20 days
Exercisable		4 years 2 months 26 days	5 years 21 days
2019 ISOP
Number of options
Outstanding at beginning of period (in shares)		2,812,500	1,972,500
Granted (in shares)		0	1,369,000
Forfeited (in shares)		(47,000)	(149,750)
Exercised (in shares)	0	(135,984)	(379,250)
Outstanding at end of period (in shares)		2,629,516	2,812,500	1,972,500	2,629,516
Exercisable (in shares)		1,476,744	455,500		1,476,744
Weighted average exercise price
Outstanding at beginning of period (in dollars per share) | $ / shares		$ 5.83	$ 4.22
Granted (in dollars per share) | $ / shares			8.75
Forfeited (in dollars per share) | $ / shares		7.25	5.54
Exercised (in dollars per share) | $ / shares		5.15	4
Outstanding at end of period (in dollars per share) | $ / shares		4.96	5.83	$ 4.22	$ 4.96
Exercisable (in dollars per share) | $ / shares		$ 4.41	$ 1.37		$ 4.41
Weighted average remaining life in years
Outstanding		7 years 2 months 15 days	8 years 7 months 9 days	9 years 1 month 9 days
Granted			9 years 1 month 13 days
Exercisable		6 years 6 months 21 days	7 years 10 months 6 days
2021 EIP
Number of options
Outstanding at beginning of period (in shares)		1,576,069	0
Granted (in shares)		1,336,284	1,595,314
Forfeited (in shares)		(288,056)	(19,245)
Exercised (in shares)		0	0
Outstanding at end of period (in shares)		2,624,297	1,576,069	0	2,624,297
Exercisable (in shares)		528,693	0		528,693
Weighted average exercise price
Outstanding at beginning of period (in dollars per share) | $ / shares		$ 17.96	$ 0
Granted (in dollars per share) | $ / shares		6.03	17.96
Forfeited (in dollars per share) | $ / shares		14	18
Outstanding at end of period (in dollars per share) | $ / shares		12.32	17.96	$ 0	$ 12.32
Exercisable (in dollars per share) | $ / shares		$ 17.98	$ 0		$ 17.98
Weighted average remaining life in years
Outstanding		8 years 10 months 17 days	9 years 6 months 25 days
Granted			9 years 6 months 25 days
Exercisable		8 years 14 days	9 years 6 months 25 days

Share-based compensation - Su_2

Share-based compensation - Summary of Valuation Inputs (Details)	12 Months Ended
	Dec. 31, 2022 $ / shares	Dec. 31, 2021 $ / shares	Dec. 31, 2020 $ / shares
2019 ISOP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share price at grant date (in dollars per share)		$ 5.59
Dividend yield (%)		0%	0%
2019 ISOP | Minimum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share price at grant date (in dollars per share)			$ 4.36
Expected life of share options (years)		6.05	5.67
Expected volatility		41.26%	39.84%
Risk free interest rate		(0.63%)	(0.80%)
2019 ISOP | Maximum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share price at grant date (in dollars per share)			$ 4.87
Expected life of share options (years)		6.19	6.43
Expected volatility		41.45%	43.56%
Risk free interest rate		(0.48%)	(0.53%)
2021 EIP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Dividend yield (%)	0%	0%
2021 EIP | Minimum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share price at grant date (in dollars per share)	$ 2.06	$ 16.81
Expected life of share options (years)	5.50	5.50
Expected volatility	62.65%	41.65%
Risk free interest rate	2.42%	0.87%
2021 EIP | Maximum
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share price at grant date (in dollars per share)	$ 8.36	$ 18
Expected life of share options (years)	7	7
Expected volatility	69.43%	59.77%
Risk free interest rate	4%	1.36%

Share-based compensation - Weig

Share-based compensation - Weighted Average Fair Value of Options Granted (Details) - $ / shares	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
2019 ISOP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Weighted average fair value of options granted (in dollars per share)		$ 2.12
2021 EIP
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Weighted average fair value of options granted (in dollars per share)	$ 3.62	$ 9.87

Share-based compensation - Move

Share-based compensation - Movements in Share-based Compensation Reserve (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Reconciliation Of Changes In Share-Based Payments [Abstract]
Balance at beginning of period	$ 11,462	$ 2,948
Movement in the period	13,613	8,514	$ 1,359
Balance at end of period	$ 25,075	$ 11,462	$ 2,948

Share-based compensation - Shar

Share-based compensation - Share-based Compensation Expense (Details) - USD ($) $ in Thousands		12 Months Ended
	Jul. 27, 2021	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share-based compensation expense	$ 300	$ 13,613	$ 8,514	$ 1,359
Research and development costs
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share-based compensation expense		2,245	784	149
Sales and marketing
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share-based compensation expense		1,462	1,227	212
General and administrative costs
Disclosure Of Terms And Conditions Of Sharebased Payment Arrangement [Line Items]
Share-based compensation expense		$ 9,906	$ 6,503	$ 998

Share-based compensation - Su_3

Share-based compensation - Summary of Restricted Stock Units Activity (Details) - Restricted Stock Units	12 Months Ended
	Dec. 31, 2022 shares $ / shares	Dec. 31, 2021 shares $ / shares
Number of RSUs
Unvested at beginning of period (in shares) | shares	287,575	0
Granted (in shares) | shares	1,776,832	290,407
Vested (in shares) | shares	(133,056)
Forfeited (in shares) | shares	(65,918)	(2,832)
Unvested at end of period (in shares) | shares	1,865,433	287,575
Weighted-average grant date fair value per share
Unvested at beginning of period (in dollars per share) | $ / shares	$ 17.97	$ 0
Granted (in dollars per share) | $ / shares	4.30	17.97
Vested (in dollars per share) | $ / shares	17.99
Forfeited (in dollars per share) | $ / shares	10.72	18
Unvested at end of period (in dollars per share) | $ / shares	$ 5.20	$ 17.97

Borrowings (Details)

Borrowings (Details) - Credit Facility	Apr. 01, 2021 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2022 CHF (SFr)	Jun. 21, 2022 CHF (SFr)	Apr. 01, 2021 EUR (€)
Credit Suisse
Disclosure Of Detailed Information About Borrowings [Line Items]
Maximum borrowings	$ 3,300,000	$ 0			€ 2,700,000
Interest rate	3.95%				3.95%
Repayment period	36 months
Credit Suisse Group AG
Disclosure Of Detailed Information About Borrowings [Line Items]
Maximum borrowings				SFr 5,000,000
Credit Suisse Group AG | Gross Carrying Amount
Disclosure Of Detailed Information About Borrowings [Line Items]
Maximum borrowings			SFr 0

TriplePoint success fee - Addit

TriplePoint success fee - Additional Information (Details)	1 Months Ended	12 Months Ended
	Sep. 30, 2021 USD ($)	Dec. 31, 2022 USD ($) $ / shares	Dec. 31, 2022 USD ($) SFr / shares	Dec. 31, 2021 USD ($)	Dec. 31, 2020 USD ($)
Triple Point Success Fee [Line Items]
Derivatives during the period		$ 0		$ 1,444,000	$ 384,000
TriplePoint Capital LLC
Triple Point Success Fee [Line Items]
Transaction strike price (in dollars per share) | (per share)		$ 3.65	SFr 3.65
Percentage of committed loan facility		6.50%
Committed loan facility amount		$ 10,000,000	SFr 10,000,000
Committed loan facility conversion rate		1.16	1.16
Derivatives during the period		$ 0		(1,444,000)	(467,000)
Gain (loss) on finance income (expenses)	$ 400,000	$ 0		$ (1,400,000)
Reduction of success fee	400,000
Success fee	$ 2,500,000				$ 2,900,000

TriplePoint success fee - Summa

TriplePoint success fee - Summary of Loss Recognized on Derivative with TriplePoint Loan (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Reconciliation Of Changes In Derivative Financial Liabilities [Abstract]
Loss on derivative	$ 0	$ (1,444,000)	$ (384,000)
TriplePoint Capital LLC
Reconciliation Of Changes In Derivative Financial Liabilities [Abstract]
Balance at beginning of period	2,468,000	1,024,000	557,000
Loss on derivative	$ 0	1,444,000	467,000
Balance at end of period		$ 2,468,000	$ 1,024,000

Initial Public Offerings (Detai

Initial Public Offerings (Details) $ / shares in Units, $ in Thousands			12 Months Ended
	Aug. 25, 2021 USD ($) $ / shares shares	Jul. 27, 2021 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) $ / shares	Dec. 31, 2021 USD ($) shares	Dec. 31, 2020 USD ($)	Dec. 31, 2022 SFr / shares	Aug. 25, 2021 SFr / shares shares	Jul. 27, 2021 SFr / shares shares
Disclosure Of Initial Public Offerings [Line Items]
Number of shares issued (in shares) | shares				63,857,604
Proceeds from issuance of share capital, net of transaction costs			$ 0	$ 0	$ 107,643
Ordinary Shares
Disclosure Of Initial Public Offerings [Line Items]
Shares issued, par value (in dollars per share) | (per share)			$ 0.05			SFr 0.05
Ordinary Shares | Initial Public Offering
Disclosure Of Initial Public Offerings [Line Items]
Number of shares issued (in shares) | shares	13,519,493	13,000,000					13,519,493	13,000,000
Shares price per share (in dollars per share) | $ / shares		$ 18
Shares issued, par value (in dollars per share) | (per share)		$ 0.05						SFr 0.05
Gross proceeds from issuance	$ 243,400	$ 234,000
Issuance costs		22,300
Proceeds from issuance of share capital, net of transaction costs		211,700
Net proceeds from IPO		$ 211,700
Preferred stock conversion ratio	1						1
Ordinary Shares | Private Placement
Disclosure Of Initial Public Offerings [Line Items]
Number of shares issued (in shares) | shares		1,111,111						1,111,111
Shares price per share (in dollars per share) | $ / shares		$ 18
Shares issued, par value (in dollars per share) | (per share)		$ 0.05						SFr 0.05
Gross proceeds from issuance		$ 20,000
Issuance costs		400
Proceeds from issuance of share capital, net of transaction costs		19,600
Net proceeds from IPO		$ 19,600
Ordinary Shares | Underwriters
Disclosure Of Initial Public Offerings [Line Items]
Number of shares issued (in shares) | shares	519,493						519,493
Shares price per share (in dollars per share) | $ / shares	$ 18
Shares issued, par value (in dollars per share) | (per share)	$ 0.05						SFr 0.05
Issuance costs	$ 900
Proceeds from issuance of share capital, net of transaction costs	8,500
Net proceeds from IPO	$ 9,400

Share capital issuance (Details

Share capital issuance (Details) $ / shares in Units, $ in Millions	Jun. 30, 2021	Sep. 23, 2020 USD ($) $ / shares shares	Jun. 25, 2020 USD ($) $ / shares shares	Dec. 31, 2021 shares
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares) | shares				63,857,604
Share split ratio	0.05
Preferred F Shares
Disclosure Of Classes Of Share Capital [Line Items]
Number of shares issued (in shares) | shares		3,652,460	5,664,480
Shares issued, par value (in dollars per share) | $ / shares		$ 11.89	$ 11.53
Gross proceeds from issuance		$ 43.4	$ 65.3
Transaction costs		0.4	0.7
Net proceeds from issuance		$ 43	$ 64.6

Related parties - Summary of Co

Related parties - Summary of Compensation for Key Management and Non-executive Directors (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure of transactions between related parties [abstract]
Salaries and other short-term employee benefits	$ 3,368	$ 2,761	$ 1,155
Pension costs	196	117	70
Share-based compensation expense	8,936	6,906	1,065
Other compensation	414	44	146
Total	$ 12,914	$ 9,828	$ 2,436

Related parties - Summary of Re

Related parties - Summary of Related Parties Participated in Sale of Series F Preferred Shares (Details) - shares	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Transactions Between Related Parties [Line Items]
Number of preferred shares purchased (in shares)		63,857,604
Preference Shares | Alychlo NV
Disclosure Of Transactions Between Related Parties [Line Items]
Number of preferred shares purchased (in shares)	233,580
Preference Shares | Generation IM Sustainable Fund III, L.P
Disclosure Of Transactions Between Related Parties [Line Items]
Number of preferred shares purchased (in shares)	389,300
Preference Shares | Total
Disclosure Of Transactions Between Related Parties [Line Items]
Number of preferred shares purchased (in shares)	622,880

Related parties - Additional In

Related parties - Additional Information (Details) $ / shares in Units, $ in Millions						12 Months Ended
	Mar. 25, 2021 USD ($) shares $ / shares	Mar. 25, 2021 SFr / shares	Mar. 24, 2021 $ / shares	Mar. 24, 2021 SFr / shares	Nov. 29, 2018 USD ($)	Dec. 31, 2022 personnel	Dec. 31, 2021 personnel	Dec. 31, 2020 shares personnel
Disclosure Of Transactions Between Related Parties [Line Items]
Number of Executive Officers | personnel						6	6	4
Number of Non-Executive Officers | personnel						7	6	4
CEO
Disclosure Of Transactions Between Related Parties [Line Items]
Number of share options granted (in shares)	127,000
Strike price (in dollars per share) | (per share)	$ 3.33	SFr 3.15	$ 4.22	SFr 4
Fair value of these options | $	$ 0.1
CEO | Minimum
Disclosure Of Transactions Between Related Parties [Line Items]
Net proceeds from IPO | $					$ 1,000
Key Management Personnel Of Entity
Disclosure Of Transactions Between Related Parties [Line Items]
Number of kay management members participating in share issuance								3
Number of instruments granted in share-based payment arrangement (in shares)								65,920

Commitments and contingencies (

Commitments and contingencies (Details) - USD ($)	Dec. 31, 2022	Nov. 01, 2022	Dec. 31, 2021
Disclosure of contingent liabilities in business combination [abstract]
Future lease payments under short-term leases not recognized	$ 200,000		$ 300,000
Commitments		$ 69,400,000
Contingent assets	0		0
Contingent liabilities	$ 0		$ 0

Financial instruments and ris_3

Financial instruments and risks - Schedule of Financial Instruments (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Financial Instruments [Line Items]
Total financial assets	$ 186,226	$ 272,345
Total financial liabilities	37,429	35,768
Financial liabilities at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial liabilities	37,429	35,768
Financial assets at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial assets	186,226	272,345
Cash and cash equivalents | Financial assets at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial assets	161,305	192,962
Term deposits | Financial assets at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial assets	17,307	72,357
Accounts receivable | Financial assets at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial assets	6,649	5,621
Other financial non-current assets | Financial assets at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial assets	965	1,405
Accounts payable | Financial liabilities at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial liabilities	6,181	6,737
Accrued expenses | Financial liabilities at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial liabilities	14,505	15,972
Lease liabilities | Financial liabilities at amortized cost
Disclosure Of Financial Instruments [Line Items]
Total financial liabilities	$ 16,743	$ 13,059

Financial instruments and ris_4

Financial instruments and risks - Additional Information (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Disclosure Of Financial Instruments [Line Items]
Cash and cash equivalents	$ 161,305	$ 192,962	$ 74,625	$ 18,069
Cash And Cash Equivalents, Term Deposits and Short-term Investments
Disclosure Of Financial Instruments [Line Items]
Maximum exposure to credit risk	$ 57,300	$ 78,200

Financial instruments and ris_5

Financial instruments and risks - Summary of Maturity Profile of Financial Liabilities (Detail) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Disclosure Of Maturity Analysis For Financial Liabilities On Contractual Discounted Cashflows [Line Items]
Lease liabilities	$ 18,233	$ 14,560
Accounts payable	6,181	6,737
Accrued expenses	14,505	15,972
Total contractual liabilities	38,919	37,269
Within 1 year
Disclosure Of Maturity Analysis For Financial Liabilities On Contractual Discounted Cashflows [Line Items]
Lease liabilities	2,950	2,018
Accounts payable	6,181	6,737
Accrued expenses	14,505	15,972
Total contractual liabilities	23,636	24,727
Between 1 and 5 years
Disclosure Of Maturity Analysis For Financial Liabilities On Contractual Discounted Cashflows [Line Items]
Lease liabilities	8,862	8,467
Accounts payable	0	0
Accrued expenses	0	0
Total contractual liabilities	8,862	8,467
After 5 years
Disclosure Of Maturity Analysis For Financial Liabilities On Contractual Discounted Cashflows [Line Items]
Lease liabilities	6,421	4,075
Accounts payable	0	0
Accrued expenses	0	0
Total contractual liabilities	6,421	4,075
Net carrying amount
Disclosure Of Maturity Analysis For Financial Liabilities On Contractual Discounted Cashflows [Line Items]
Lease liabilities	16,743	13,059
Accounts payable	6,181	6,737
Accrued expenses	14,505	15,972
Total contractual liabilities	$ 37,429	$ 35,768

Financial instruments and ris_6

Financial instruments and risks - Summary of Significant Exchange Rates (Detail)	12 Months Ended
	Dec. 31, 2022 $ / SFr	Dec. 31, 2022 $ / € $ / SFr	Dec. 31, 2022 $ / SFr $ / £	Dec. 31, 2022 $ / SFr $ / R$	Dec. 31, 2021 $ / SFr	Dec. 31, 2021 $ / SFr $ / €	Dec. 31, 2021 $ / £ $ / SFr	Dec. 31, 2021 $ / SFr $ / R$	Dec. 31, 2020 $ / SFr	Dec. 31, 2020 $ / €	Dec. 31, 2020 $ / £	Dec. 31, 2020 $ / R$	Dec. 31, 2022 $ / €	Dec. 31, 2022 $ / £	Dec. 31, 2022 $ / R$	Dec. 31, 2021 $ / €	Dec. 31, 2021 $ / £	Dec. 31, 2021 $ / R$
Foreign exchange rates [abstract]
Spot rate (in dollars per share)	0.92447	0.92447	0.92447	0.92447	0.91210	0.91210	0.91210	0.91210					0.93414	0.82761	5.28600	0.88290	0.74190	5.57130
Average rate (in dollars per share)	0.95500	0.95146	0.81177	5.16678	0.91437	0.84579	0.72707	5.39288	0.94703	0.88423	0.78132	5.06281

Financial instruments and ris_7

Financial instruments and risks - Sensitivity of Loss Before Tax To Changes in Foreign Exchange Rates (Detail) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	$ (447)	$ 64	$ (2,710)
Functional Currency | USD/CHF | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	6,614	19,499	1,453
Functional Currency | USD/CHF | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	(6,614)	(19,499)
Functional Currency | EUR/CHF | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	94	648	836
Functional Currency | EUR/CHF | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	(94)	(648)	(836)
Functional Currency | GBP/CHF | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	83	18	351
Functional Currency | GBP/CHF | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	(83)	(18)	(351)
Functional Currency | USD/EUR | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	503	726	155
Functional Currency | USD/EUR | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Foreign exchange gains (losses), net	$ (503)	$ (726)	$ (155)

Financial instruments and ris_8

Financial instruments and risks - Sensitivity of Equity To Changes in Foreign Exchange Rates (Detail) - Presentation Currency - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
USD/CHF | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	$ 14,198	$ 54
USD/CHF | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	(14,198)	(54)
USD/EUR | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	44	89
USD/EUR | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	(44)	(89)
USD/GBP | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	50	27
USD/GBP | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	(50)	(27)
USD/BRL | Maximum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	133	77
USD/BRL | Minimum
Disclosure Of Effect Of Changes In Foreign Exchange Rates [Line Items]
Increase / (decrease) of equity in exchange rate	$ (133)	$ (77)

Capital management (Details)

Capital management (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019
Capital commitments [abstract]
Cash and cash equivalents	$ 161,305	$ 192,962	$ 74,625	$ 18,069