| Cover | Mar. 30, 2022 |
| Document Information [Line Items] | |
| Document Type | 8-K |
| Document Period End Date | Mar. 30, 2022 |
| Entity Registrant Name | CENTESSA PHARMACEUTICALS PLC |
| Entity Incorporation, State or Country Code | X0 |
| Entity File Number | 001-04321 |
| Entity Address, Address Line One | 3rd Floor |
| Entity Address, Address Line Two | 1 Ashley Road |
| Entity Address, Address Line Three | Altrincham |
| Entity Address, City or Town | Cheshire |
| Entity Address, Postal Zip Code | WA14 2DT |
| Entity Address, Country | GB |
| Country Region | +44 |
| City Area Code | 7391 |
| Local Phone Number | 789784 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Amendment Flag | false |
| Entity Central Index Key | 0001847903 |
| Entity Tax Identification Number | 98-1612294 |
| Ordinary shares | |
| Document Information [Line Items] | |
| Title of 12(b) Security | Ordinary shares, nominal value £0.002 per share |
| Trading Symbol | CNTA |
| Security Exchange Name | NASDAQ |
| American Depositary Shares | |
| Document Information [Line Items] | |
| Title of 12(b) Security | American Depositary Shares, each representing one ordinary share, nominal value £0.002 per share |
| Trading Symbol | CNTA |
| Security Exchange Name | NASDAQ |
