Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” and to the use of our report dated March 19, 2021, in the Registration Statement (Form S-1) and related Prospectus of Singular Genomics Systems, Inc. for the registration of shares of its common stock.
/s/ Ernst & Young LLP
San Diego, California
May 7, 2021
