Cover
| Cover | May 17, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | May 17, 2023 |
| Entity File Number | 001-41210 |
| Entity Registrant Name | HILLSTREAM BIOPHARMA, INC. |
| Entity Central Index Key | 0001861657 |
| Entity Tax Identification Number | 84-2642541 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 1200 Route 22 East |
| Entity Address, Address Line Two | Suite 2000 |
| Entity Address, City or Town | Bridgewater |
| Entity Address, State or Province | NJ |
| Entity Address, Postal Zip Code | 08807 |
| City Area Code | (908) |
| Local Phone Number | 955-3140 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common stock, $0.0001 par value |
| Trading Symbol | HILS |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Elected Not To Use the Extended Transition Period | false |
| Entity Information, Former Legal or Registered Name | Not Applicable |