Chapman and Cutler LLP
111 West Monroe Street
Chicago, Illinois 60603
August 3, 2021
Via EDGAR Filing
Mr. Edward Bartz
Division of Investment Management
Securities and Exchange Commission
100 F Street, N.E.
Washington, DC 20549
Re: Guggenheim Defined Portfolios, Series 2151
ARK Early Stage Disruptors Portfolio, Series 1
File Nos. 333-257325 and 811-03763
Dear Mr. Bartz:
This letter responds to your comment given during a telephone conversation with our office regarding amendment no. 1 to the registration statement on Form S-6 for Guggenheim Defined Portfolios, Series 2151, filed on August 2, 2021, with the Securities and Exchange Commission. The registration statement proposes to offer the ARK Early Stage Disruptors Portfolio, Series 1 (the “trust”).
PROSPECTUS
Investment Summary — Principal Investment Strategy
1. In the third paragraph, please disclose that the trust is not expected to track the price movements of any cryptocurrencies.
Response: The requested disclosure has been added in response to this comment.
We appreciate your prompt attention to this registration statement. If you have any questions or comments or would like to discuss our responses to your questions, please feel free to contact the undersigned at (312) 845-3484.
Very truly yours,
Chapman and Cutler LLP
By /s/ Morrison C. Warren
Morrison C. Warren
