Asia Pacific Bangkok Beijing Brisbane Hanoi Ho Chi Minh City Hong Kong Jakarta Kuala Lumpur* Manila* Melbourne Seoul Shanghai Singapore Sydney Taipei Tokyo Yangon Europe, Middle East & Africa Abu Dhabi Almaty Amsterdam Antwerp Bahrain Barcelona Berlin Brussels Budapest Cairo Casablanca Doha Dubai Dusseldorf Frankfurt/Main Geneva Istanbul Jeddah* Johannesburg Kyiv London Luxembourg Madrid Milan Munich Paris Prague Riyadh* Rome Stockholm Vienna Warsaw Zurich The Americas Bogota Brasilia** Buenos Aires Caracas Chicago Dallas Guadalajara Houston Juarez Lima Los Angeles Mexico City Miami Monterrey New York Palo Alto Porto Alegre** Rio de Janeiro** San Francisco Santiago Sao Paulo** Tijuana Toronto Valencia Washington, DC * Associated Firm ** In cooperation with Trench, Rossi e Watanabe Advogados | | February 7, 2023 MDxHealth SA CAP Business Center Zone Industrielle des Hauts-Sarts Rue d’Abhooz 31 4040 Herstal Belgium Ladies and Gentlemen, RE: MDXHEALTH SA – OFFERING OF AMERICAN DEPOSITARY SHARES 1. Introduction (a) We have acted as external Belgian law counsel to MDxHealth SA of CAP Business Center, Zone Industrielle des Hauts-Sarts, Rue d’Abhooz 31, 4040 Herstal, Belgium, registered under company number 0479.292.440 RLP Liège (division Liège) (the “Company”), on certain Belgian law aspects relating to the Registration Statement (as defined below) filed with the United States Securities and Exchange Commission (the “SEC”) under the United States Securities Act of 1933, as amended (the “Securities Act”), in respect of the Company’s offering of American Depositary Shares (the “ADSs”), representing new ordinary shares without nominal value of the Company (the “New Shares”), with admission to trading and listing of the ADSs on the Nasdaq Capital Market, covered by the Registration Statement to which this opinion is an exhibit (the ” Offering”). (b) For the purposes of this opinion letter (the “Opinion Letter”): (i) we have reviewed only the documents referred to in paragraph 3 (Documents Reviewed); and (ii) we have completed only the searches and enquiries referred to in paragraph 4 (Searches and Enquiries); |
| Partners GABRIEL, François1,3* HUYGHE, Alain1,3* VANHAERENTS, Koen1* FESLER, Daniel1,3* VANDENBERGHE, Jean-François1,3* LUYTEN, Nancy1,3* MEERS, Roel1,3* MEEUS, Luc1,3,5* CARLIN, Fiona1,3,6* HAEGEMAN, Kurt1,3* MAES, Dominique1,3* VAN ACKER, Michael1,3* BOMBEKE, Géry1,3* DEHARENG, Elisabeth1,3* BOVY, Geert1,3* BUSHELL, Gavin1,3,4* | BURG, Sebastian1 MARTENS, Davinia1,3 LEBRUN, Gregory1,3 JOHNSON, Paul1,3,4 PERMEKE, Julie1 Senior Counsels & Counsels SLOOTMANS, Jozef1 DE WINTER, Koen2,3 MALLIEN, Pascal2,3 LION, Philippe1,3 VAN HOOREBEKE, Annick1 VAN BAELEN, Olivier1 HOUBEN, Robby2 JANSSENS, Els1 | STAS, Kim1 HOORELBEKE, Bram1 Associates DEKETELAERE, Mario2 JANSSEUNE, Joren1 NAERT, Arne1,3 VAN DEN BROEKE, Olivier2 COX, Kristoff1 TANS, Michel1,3 VAN THIENEN, Julie1 TYTGAT, Sebastian1,3 DENYS, Pieter-Jan1,3 VERBEEK, Helena1,3 VANDEN BERGHE, Harold1 WILLEMS, Lien1 | WALSCHOT, Nastassja1 ROYER, Céline1,3 SEBBARH, Younes1,3 ALLAERTS, Margo2 CLAEYS, Eva1 CORNE, Anne-Sophie1 VYNCKIER, Joost1,3 ILLEGEMS, Steffi1 KETTLEWELL, William-James1,3 VERSCHRAEGEN, Samuel1, FLAMAND Arnaud1,3 | Associated with the Brussels Bar NIEJAHR, Nina8 YILMAZ, Sibel13 WEINERT, Lisa3,8 GUELTON, Sylvain9 STEFANOU, Dimitrios3,12 SAINT-CAST, Victor14 NOWICKA-MCLEES, Alexandra Nina4 DERHAB, Sara9 |