Alopexx (ALPX) S-1/A IPO registration (amended)

ALOPEXX, INC. S-1/A

Exhibit 23.1

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM’S CONSENT

We consent to the inclusion in this Registration Statement of Alopexx, Inc. on Form S-1 Amendment No. 15 (File N0. 333-263328) of our report dated March 14, 2024, which includes an explanatory paragraph as to the Company’s ability to continue as a going concern, with respect to our audits of the financial statements of Alopexx, Inc. as of December 31, 2023 and 2022 and for the years ended, which report appears in the Prospectus, which is part of this Registration Statement. We also consent to the reference to our Firm under the heading “Experts” in such Prospectus.

/s/ Marcum LLP

Marcum LLP

Hartford, CT

January 8, 2025