| Cover | May 11, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Document Period End Date | May 11, 2023 |
| Entity Registrant Name | Prime Medicine, Inc. |
| Entity Incorporation, State or Country Code | DE |
| Entity File Number | 001-41536 |
| Entity Tax Identification Number | 84-3097762 |
| Entity Address, Address Line One | 21 Erie Street |
| Entity Address, City or Town | Cambridge |
| Entity Address, State or Province | MA |
| Entity Address, Address Line One | 02139 |
| City Area Code | 617 |
| Local Phone Number | 564-0013 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common stock, par value $.00001 per share |
| Trading Symbol | PRME |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Entity Central Index Key | 0001894562 |
| Amendment Flag | false |
