| Document and Entity Information | Nov. 10, 2022 |
| Document And Entity Information [Line Items] | |
| Amendment Flag | false |
| Entity Central Index Key | 0001907685 |
| Document Type | 8-K |
| Document Period End Date | Nov. 10, 2022 |
| Entity Registrant Name | Comera Life Sciences Holdings, Inc. |
| Entity Incorporation State Country Code | DE |
| Entity File Number | 1-41403 |
| Entity Tax Identification Number | 87-4706968 |
| Entity Address, Address Line One | 12 Gill |
| Entity Address, Address Line Two | Street |
| Entity Address, Address Line Three | Suite 4650 |
| Entity Address, City or Town | Woburn |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 01801 |
| City Area Code | (617) |
| Local Phone Number | 871-2101 |
| Written Communications | false |
| Soliciting Material | false |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Common Stock [Member] | |
| Document And Entity Information [Line Items] | |
| Security 12b Title | Common Stock |
| Trading Symbol | CMRA |
| Security Exchange Name | NASDAQ |
| Warrant [Member] | |
| Document And Entity Information [Line Items] | |
| Security 12b Title | Warrants |
| Trading Symbol | CMRAW |
| Security Exchange Name | NASDAQ |
