Vivo Opportunity Fund SC 13G Regulus Therapeutics / Vivo Opportunity Fund ownership change

EXHIBIT 99.1

Joint Filing Agreement

The undersigned acknowledge and agree that the foregoing statement on Schedule 13G is filed on behalf of each of the undersigned and that all subsequent amendments to this statement on Schedule 13G shall be filed on behalf of each of the undersigned without the necessity of filing additional joint filing statements. The undersigned acknowledge that each shall be responsible for the timely filing of such amendments, and for the completeness and accuracy of the information concerning him, her or it contained herein, but shall not be responsible for the completeness and accuracy of the information concerning the other entities or persons, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate.

Date: March 20, 2024

Vivo Opportunity Fund Holdings, L.P.
By: Vivo Opportunity, LLC, its General Partner
/s/ Kevin Dai
Name:	Kevin Dai
Title:	Managing Member
Vivo Opportunity, LLC
/s/ Kevin Dai
Name:	Kevin Dai
Title:	Managing Member