| Cover Page - USD ($) $ in Millions | 12 Months Ended | | |
| Dec. 31, 2022 | Apr. 15, 2023 | Jun. 30, 2022 |
| Document Information [Line Items] | | | |
| Document Type | 10-K/A | | |
| Document Annual Report | true | | |
| Document Period End Date | Dec. 31, 2022 | | |
| Current Fiscal Year End Date | --12-31 | | |
| Document Transition Report | false | | |
| Entity File Number | 001-41535 | | |
| Entity Registrant Name | ZYMEWORKS INC. | | |
| Entity Incorporation, State or Country Code | DE | | |
| Entity Tax Identification Number | 88-3099146 | | |
| Entity Address, Address Line Two | 108 Patriot Drive | | |
| Entity Address, Address Line One | Suite A | | |
| Entity Address, City or Town | Middletown | | |
| Entity Address, State or Province | DE | | |
| Entity Address, Postal Zip Code | 19709 | | |
| City Area Code | 302 | | |
| Local Phone Number | 274-8744 | | |
| Entity Well-known Seasoned Issuer | No | | |
| Entity Voluntary Filers | No | | |
| Entity Current Reporting Status | Yes | | |
| Entity Filer Category | Non-accelerated Filer | | |
| Entity Interactive Data Current | Yes | | |
| Entity Small Business | true | | |
| Entity Emerging Growth Company | false | | |
| ICFR Auditor Attestation Flag | false | | |
| Entity Shell Company | false | | |
| Entity Public Float | | | $ 306 |
| Entity Common Stock, Shares Outstanding | | 64,136,928 | |
| Documents Incorporated by Reference | None. | | |
| Amendment Flag | true | | |
| Document Fiscal Year Focus | 2022 | | |
| Document Fiscal Period Focus | FY | | |
| Entity Central Index Key | 0001937653 | | |
| Amendment Description | This Amendment No. 1 on Form 10-K/A (this “Amendment”), amends Zymeworks Inc.’s (the “Company,” “Zymeworks,” “we,” “us,” and “our”) Annual Report on Form 10-K for the year ended December 31, 2022, originally filed with the Securities and Exchange Commission (the “SEC”) on March 7, 2023 (the “Original Filing”). We are amending and refiling Part III to include information required by Items 10, 11, 12, 13 and 14 because our definitive proxy statement will not be filed within 120 days after December 31, 2022, the end of the fiscal year covered by our Annual Report on Form 10-K. Pursuant to the rules of the SEC, we have also included as exhibits currently dated certifications required under Section 302 of The Sarbanes-Oxley Act of 2002. Because no financial statements are contained within this Amendment, we are not including certifications pursuant to Section 906 of The Sarbanes-Oxley Act of 2002. We are amending and refiling Part IV to reflect the inclusion of those certifications, along with any changes to Part IV that occurred after the date of the Original Filing. In addition, we made certain revisions to the cover page, including the deletion of the reference to our proxy statement and the amendment to our Annual Report on Form 10-K and inclusion of updated outstanding share information. Except as described above, no other changes have been made to the Original Filing. Except as otherwise indicated herein, this Amendment continues to speak as of the date of the Original Filing, and we have not updated the disclosures contained therein to reflect any events that occurred subsequent to the date of the Original Filing. The filing of this Amendment is not a representation that any statements contained in items of our annual report on Form 10-K other than Part III, Items 10 through 14, Part IV and the aforementioned portions of the cover page are true or complete as of any date subsequent to the Original Filing. | | |
| Common stock | | | |
| Document Information [Line Items] | | | |
| Title of 12(b) Security | Common Stock, $0.00001 par value per share | | |
| Trading Symbol | ZYME | | |
| Security Exchange Name | NASDAQ | | |
| Preferred Stock Purchase Rights | | | |
| Document Information [Line Items] | | | |
| Title of 12(b) Security | Preferred Stock Purchase Rights | | |
| No Trading Symbol Flag | true | | |
| Security Exchange Name | NASDAQ | | |
