Exhibit 5.1
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| Reed Smith LLP 599 Lexington Avenue New York, NY 10022-7650 +1 212 521 5400 Fax +1 212 521 5450 reedsmith.com |
January 13, 2025
Adagio Medical Holdings, Inc.
26051 Merit Circle, Suite 102
Laguna Hills, CA 92653
Ladies and Gentlemen:
We have acted as counsel to Adagio Medical Holdings, Inc. (f/k/a Aja Holdco, Inc.), a Delaware corporation (the “Company”), in connection with the preparation and filing by the Company with the Securities and Exchange Commission (the “Commission”) of a registration statement on Form S-1 (the “Registration Statement”) relating to the registration of (i) up to 23,239,933 shares (the “Additional Convertible Note Shares”) of common stock, $0.0001 par value per share, of the Company (the “Common Stock”) issuable upon the conversion of those certain 13% senior secured convertible notes (the "Convertible Notes") issued pursuant that certain securities purchase agreement, dated February 13, 2024, by and among the Company and certain investors named therein, and any assignment thereunder (the “Convertible Security Subscription Agreement”) and that certain note purchase agreement, dated February 13, 2024, by and among the Company, Adagio Medical, Inc., a Delaware corporation (“Adagio Medical”), and Perceptive Life Sciences Master Fund, Ltd (“Perceptive”), a Cayman Islands exempted company (the “2024 Bridge Financing Note Subscription Agreement” and together with the Convertible Security Subscription Agreement, the “Convert Subscription Agreements”) and (ii) up to 73,333 shares of Common Stock (the “Registration Delay Shares”) issued pursuant to the terms of the Convert Waiver, dated January 3, 2025, by and among the Company, Adagio Medical and holder thereto (the "Convert Waiver").
Pursuant to Rule 429, the prospectus contained in the Registration Statement (the “Prospectus”) also covers (i) up to 7,905,387 shares of Common Stock issuable upon conversion of the Convertible Notes (the “Original Convertible Note Shares” and, together with the Additional Convertible Note Shares, the “Convertible Note Shares”), and (ii) up to 600,000 shares of Common Stock (the “Convert Warrant Shares”) issuable upon exercise of those warrants to purchase shares of Common Stock, with an exercise price of $24.00 per share (the “Warrants”), issued pursuant to the Convertible Security Subscription Agreement, which securities were previously registered on the Company’s registration statement on Form S-1 initially filed the Commission on September 13, 2024 (File No. 333-282126).
This opinion letter is being furnished in accordance with the requirements of Item 601(b)(5) of Regulation S-K under the Securities Act.
We have reviewed originals or copies of (a) the Registration Statement, (b) the Business Combination Agreement, dated as of February 13, 2024, by and among the Company, Arya Sciences Acquisition Corp IV, a Cayman islands exempted Company (“ARYA”), Adagio Medical, and the other parties thereto, as amended (the “Business Combination Agreement”), (c) the Company’s certificate of incorporation and bylaws, each as currently in effect, (d) the PIPE Subscription Agreements (e) the Convertible Security Subscription Agreement (f) the Convert Warrant Agreement, (g) the Convert Waiver and (h) the Registration Rights Agreement, dated as of July 31, 2024, by and between the Company, Perceptive Life Sciences Master Fund, Ltd. and each holder thereto (the “Convert Registration Rights Agreement” and together with the Business Combination Agreement, the Convertible Security Subscription Agreement, the Convert Warrant Agreement, and the Convert Waiver, the “Transaction Documents”), and such other corporate records, agreements and documents of the Company, certificates or comparable documents of public officials and officers of the Company and have made such other investigations as we have deemed necessary as a basis for the opinions set forth below.