Provectus Biopharmaceuticals (PVCT) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

April 26, 2016

Securities and Exchange Commission

100 F Street N.E.

Washington, D.C. 20549

We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on April 26, 2016, to be filed by our former client, Provectus Biopharmaceuticals, Inc. We agree with the statements made in response to that Item insofar as they relate to our Firm.

Very truly yours,

/s/ BDO USA, LLP