| Cover | Mar. 16, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Mar. 16, 2023 |
| Entity File Number | 001-09974 |
| Entity Registrant Name | Enzo Biochem, Inc. |
| Entity Central Index Key | 0000316253 |
| Entity Tax Identification Number | 13-2866202 |
| Entity Incorporation, State or Country Code | NY |
| Entity Address, Address Line One | 81 Executive Blvd. |
| Entity Address, Address Line Two | Suite 3 |
| Entity Address, City or Town | Farmingdale |
| Entity Address, State or Province | NY |
| Entity Address, Postal Zip Code | 11735 |
| City Area Code | 212 |
| Local Phone Number | 583-0100 |
| Written Communications | false |
| Soliciting Material | true |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, $0.01 par value |
| Trading Symbol | ENZ |
| Security Exchange Name | NYSE |
| Entity Emerging Growth Company | false |
