Our financial performance was strong. ● We delivered aone-year total shareholder return, or TSR, of 15% and a five-year TSR of 93%, outperforming our peer group and the Standard & Poor’s 500 Index over both time periods. ● As referenced below, we returned $21.4 billion of capital to our stockholders. Further, we increased our quarterly dividend per share 15% over 2017 (to $1.32 per share for 2018). We executed on our strategic priorities in 2018. Our strategy includes a series of integrated activities to strengthen our long-term competitive position in the industry. These 2018 activities include the strategic priorities discussed below (and in further detail in our 2019 proxy statement): ● Discovering and advancinginnovative medicines that address important unmet medical needs. ◾ Welaunched Aimovig®‡and Parsabiv®, twoinnovative products, in the U.S. in twodifferent therapeutic areas (migraine and nephrology). ◾ We continued to advance ourearly pipeline. We initiated 10first-in-human studies and, in the oncology pipeline, we are advancing approximately 20 early-stage product candidates. ● Developingbranded biosimilars. ◾ Welaunched KANJINTI™ (biosimilar trastuzumab (Herceptin®)) andAMGEVITA™(biosimilar adalimumab (HUMIRA®) in Europe also in twodifferent therapeutic areas (oncology and inflammation). ● Transforming Amgen for the future. ◾ We realized our 2014-2018 commitments to investors and our transformation objectives. ◾ 2018 was the capstone year for a set of ambitiousnon-GAAP financial commitments that we made to our stockholders five years ago, including earnings per share growth, operating margin improvement, and return of capital, that we met and exceeded throughsignificant transformation and process improvement efforts. ◾ We have embedded the productivity capabilities developed through our transformation activities in our business to reallocate resources to our pipeline and growth opportunities putting us in a better position to serve patients and deliver long-term growth. ● Adhering to a disciplined approach tocapital allocation whileinvesting for long-term growth. ◾ We invested $3.7 billion in research and development and $738 million in capital expenditures. ◾ We repurchased $17.9 billion of our Common Stock and paid dividends totaling $3.5 billion, resulting in our returning a total of $21.4 billion of capital to our stockholders through stock repurchases and dividends. ● Expanding ourglobal geographic reach. ◾ Between 2011 and 2018, we have increased our global presence to ~100 countries from 50. ● Deployingnext-generation biomanufacturing facilities. ◾ We successfully operated our next-generation manufacturing facility in Singapore and broke ground on a next-generation biomanufacturing plant in Rhode Island. This new plant will be the first of its kind in the U.S. ◾ Next-generation biomanufacturing plants require a smaller manufacturing footprint and offer greater environmental benefits, including reduced consumption of water and energy and lower levels of carbon emissions. ● Improvingdrug delivery systems. ◾ We have invested in delivery devices to enhance patient experiences, including our SureClick® autoinjector for Aimovig. Item 3: Our Board recommends “FOR” the ratification of the selection of Ernst & Young LLP as our independent registered public accountants. Our Audit Committee periodically considers whether there should be a rotation of our independent registered public accountants. Each year, the Audit Committee evaluates the performance of the independent registered public accountants and determines after such evaluation whether tore-engage the current independent registered public accountants. ‡ Jointly developed in collaboration with Novartis AG. |