| Cover - USD ($) $ in Millions | 12 Months Ended | | |
| Dec. 31, 2021 | Apr. 21, 2022 | Jun. 30, 2021 |
| Cover [Abstract] | | | |
| Document Type | 10-K/A | | |
| Document Annual Report | true | | |
| Document Period End Date | Dec. 31,
2021 | | |
| Current Fiscal Year End Date | --12-31 | | |
| Document Transition Report | false | | |
| Entity File Number | 001-33650 | | |
| Entity Registrant Name | CALADRIUS BIOSCIENCES, INC. | | |
| Entity Central Index Key | 0000320017 | | |
| Document Fiscal Year Focus | 2021 | | |
| Document Fiscal Period Focus | FY | | |
| Amendment Flag | true | | |
| Entity Incorporation, State or Country Code | DE | | |
| Entity Tax Identification Number | 22-2343568 | | |
| Entity Address, Address Line One | 110 Allen Road, 2nd Floor | | |
| Entity Address, City or Town | Basking Ridge | | |
| Entity Address, State or Province | NJ | | |
| Entity Address, Postal Zip Code | 07920 | | |
| City Area Code | 908 | | |
| Local Phone Number | 842-0100 | | |
| Title of 12(b) Security | Common Stock, par value $0.001 per share | | |
| Trading Symbol | CLBS | | |
| Security Exchange Name | NASDAQ | | |
| Entity Well-known Seasoned Issuer | No | | |
| Entity Voluntary Filers | No | | |
| Entity Current Reporting Status | Yes | | |
| Entity Interactive Data Current | Yes | | |
| Entity Filer Category | Non-accelerated Filer | | |
| Entity Small Business | true | | |
| Entity Emerging Growth Company | false | | |
| ICFR Auditor Attestation Flag | false | | |
| Entity Shell Company | false | | |
| Entity Public Float | | | $ 95 |
| Entity Common Stock, Shares Outstanding | | 60,521,635 | |
| Documents Incorporated by Reference | None. | | |
| Amendment Description | This registrant is filing this Amendment No. 1 ("Amendment No. 1") to its Annual Report on Form 10-K for the year ended December 31, 2021 as filed with the Securities and Exchange Commission (the "SEC") on March 22, 2022 (the “Original Filing”) solely to include the information required by Item 10 - “Directors, Executive Officers and Corporate Governance”, Item 11 - “Executive Compensation”, Item 12 - “Security Ownership of Certain Beneficial Owners and Management and Related Stockholder Matters”, Item 13 - “Certain Relationships and Related Transactions, and Director Independence” and Item 14 - “Principal Accounting Fees and Services” of Part III of Form 10-K. The reference on the cover page of the Original Filing to the incorporation by reference of portions of our definitive proxy statement into Part III of the Original Filing is hereby deleted. Items 10, 11, 12, 13 and 14 of Part III of the Original Filing are amended and restated in their entirety as set forth in this Amendment No. 1. In addition, pursuant to Rule 13a-14(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), we are including with this Amendment No. 1 certain currently dated certifications. Because no financial statements have been included in this Amendment No. 1 and this Amendment No. 1 does not contain or amend any disclosure with respect to Items 307 and 308 of Regulation S-K, paragraphs 3, 4 and 5 of the certifications have been omitted. We are not including the certifications under Section 906 of the Sarbanes-Oxley Act of 2002 as no financial statements are being filed with this Amendment No. 1. Except as described above, no other amendments are being made to the Original Filing. This Amendment No. 1 does not reflect events occurring after the March 22, 2022 filing of the Original Filing or modify or update the disclosure contained in the Original Filing in any way other than as required to reflect the amendments discussed above and reflected below. Accordingly, this Amendment No. 1 should be read in conjunction with the Original Filing and our other filings with the SEC. | | |
