American Science & Engineering (ASEI) 10-K 2010 FY Annual report

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

As independent registered public accountants, we hereby consent to the incorporation by reference of our report dated June 7, 2010, relating to the consolidated financial statements and the effectiveness of internal control over financial reporting of American Science and Engineering, Inc. and subsidiary included in this Form 10-K for the year ended March 31, 2010 into the Company’s previously filed Registration Statements on Form S-8 (Nos. 333-05797,  333-13259, 333-27927, 333-69717, 333-91801, 333-53842, 333-102338, 333-117843, 333-117844, 333-129851, 333-152541, 333-155215 and 333-162291 ) and Form S-3 (Nos. 033-61903, 333-09151 and 333-89836).

/s/ Caturano and Company, P.C.

Boston, MA

June 7, 2010