INFORMATION REQUIRED IN REGISTRATION STATEMENT
Medtronic Global Holdings, S.C.A. (“Medtronic Luxco”), Medtronic Public Limited Company (“Medtronic plc”), and Medtronic, Inc. (“Medtronic, Inc.” and together with Medtronic Luxco and Medtronic plc, the “Registrants”) have filed with the Securities and Exchange Commission (the “Commission”) pursuant to Rule 424(b) under the Securities Act of 1933, as amended (the “Securities Act”), a prospectus supplement, dated June 25, 2019 (the “Prospectus Supplement”), and the accompanying prospectus, dated February 3, 2017 (the “Base Prospectus”). The Prospectus Supplement relates to the issuance and sale by Medtronic Luxco of €250,000,000 principal amount of its Floating Rate Senior Notes due 2021 (the “Floating Rate Notes”), €750,000,000 principal amount of its 0.00% Senior Notes due 2022 (the “2022 Notes”), €1,000,000,000 principal amount of its 0.25% Senior Notes due 2025 (the “2025 Notes”), €1,000,000,000 principal amount of its 1.00% Senior Notes due 2031 (the “2031 Notes”), €1,000,000,000 principal amount of its 1.50% Senior Notes due 2039 (the “2039 Notes”) and €1,000,000,000 principal amount of its 1.75% Senior Notes due 2049 (the “2049 Notes”, and together with the Floating Rate Notes, the 2022 Notes, the 2025 Notes, the 2031 Notes, and the 2039 Notes, the “Notes”). The Notes will be fully and unconditionally guaranteed by Medtronic plc and Medtronic, Inc. The Base Prospectus forms a part of the Registrants’ Registration Statement on FormS-3 (FileNo. 333-215895), filed with the