Common Stocks - 98.3% |
| | Shares | Value ($) |
Biotechnology - 18.6% | | | |
Biotechnology - 18.6% | | | |
ADC Therapeutics SA (a)(b) | | 150,000 | 723,000 |
Agios Pharmaceuticals, Inc. (a)(b) | | 60,000 | 1,696,800 |
Alnylam Pharmaceuticals, Inc. (a) | | 54,000 | 10,808,640 |
Ambrx Biopharma, Inc. ADR (a) | | 60,000 | 64,800 |
Arcutis Biotherapeutics, Inc. (a) | | 111,000 | 2,121,210 |
Argenx SE ADR (a) | | 69,000 | 24,360,450 |
Ascendis Pharma A/S sponsored ADR (a) | | 110,474 | 11,407,545 |
Avid Bioservices, Inc. (a) | | 99,124 | 1,895,251 |
Beam Therapeutics, Inc. (a)(b) | | 56,000 | 2,667,840 |
Biogen, Inc. (a) | | 20,000 | 5,340,000 |
Blueprint Medicines Corp. (a) | | 118,400 | 7,801,376 |
Celldex Therapeutics, Inc. (a) | | 90,000 | 2,529,900 |
Century Therapeutics, Inc. (a) | | 118,000 | 1,167,020 |
Cerevel Therapeutics Holdings (a) | | 188,900 | 5,338,314 |
Cytokinetics, Inc. (a) | | 240,000 | 11,628,000 |
Denali Therapeutics, Inc. (a) | | 70,000 | 2,148,300 |
Erasca, Inc. (a) | | 350,100 | 2,730,780 |
Exelixis, Inc. (a) | | 123,921 | 1,943,081 |
Fate Therapeutics, Inc. (a)(b) | | 40,000 | 896,400 |
Generation Bio Co. (a)(b) | | 63,300 | 336,123 |
Graphite Bio, Inc. (a) | | 100,000 | 317,000 |
Imago BioSciences, Inc. (a) | | 50,000 | 752,500 |
Innovent Biologics, Inc. (a)(c) | | 1,080,000 | 3,319,182 |
Instil Bio, Inc. (a) | | 190,000 | 919,600 |
Janux Therapeutics, Inc. (a) | | 80,000 | 1,083,200 |
Keros Therapeutics, Inc. (a) | | 60,000 | 2,257,200 |
Legend Biotech Corp. ADR (a) | | 208,000 | 8,486,400 |
Mirati Therapeutics, Inc. (a) | | 28,000 | 1,955,520 |
Morphic Holding, Inc. (a) | | 47,300 | 1,338,590 |
Nuvalent, Inc. Class A (a)(b) | | 55,067 | 1,070,502 |
Poseida Therapeutics, Inc. (a) | | 229,287 | 809,383 |
PTC Therapeutics, Inc. (a) | | 145,900 | 7,324,180 |
Regeneron Pharmaceuticals, Inc. (a) | | 48,500 | 33,410,195 |
Relay Therapeutics, Inc. (a)(b) | | 170,000 | 3,802,900 |
Sarepta Therapeutics, Inc. (a) | | 108,000 | 11,938,320 |
Scholar Rock Holding Corp. (a) | | 24,795 | 171,829 |
Shattuck Labs, Inc. (a) | | 36,553 | 98,693 |
Stoke Therapeutics, Inc. (a) | | 60,000 | 770,400 |
uniQure B.V. (a) | | 90,000 | 1,688,400 |
Vaxcyte, Inc. (a) | | 100,000 | 2,400,000 |
Vertex Pharmaceuticals, Inc. (a) | | 48,000 | 13,897,920 |
Verve Therapeutics, Inc. (a) | | 34,000 | 1,167,900 |
Xencor, Inc. (a) | | 210,000 | 5,455,800 |
Xenon Pharmaceuticals, Inc. (a) | | 66,821 | 2,412,238 |
Zai Lab Ltd. (a) | | 1,000,000 | 3,404,379 |
Zentalis Pharmaceuticals, Inc. (a) | | 130,000 | 2,815,800 |
| | | 210,672,861 |
Health Care Equipment & Supplies - 17.6% | | | |
Health Care Equipment - 17.6% | | | |
Boston Scientific Corp. (a) | | 1,480,000 | 57,320,400 |
Envista Holdings Corp. (a) | | 160,000 | 5,249,600 |
Inspire Medical Systems, Inc. (a) | | 35,000 | 6,207,950 |
Insulet Corp. (a) | | 135,511 | 31,086,223 |
Masimo Corp. (a) | | 105,000 | 14,821,800 |
Nevro Corp. (a) | | 118,000 | 5,498,800 |
Novocure Ltd. (a) | | 67,000 | 5,090,660 |
Outset Medical, Inc. (a) | | 140,000 | 2,230,200 |
Penumbra, Inc. (a) | | 202,743 | 38,440,073 |
PROCEPT BioRobotics Corp. | | 85,000 | 3,524,100 |
ResMed, Inc. | | 85,000 | 18,555,500 |
Tandem Diabetes Care, Inc. (a) | | 228,000 | 10,909,800 |
| | | 198,935,106 |
Health Care Providers & Services - 32.5% | | | |
Health Care Facilities - 3.6% | | | |
Cano Health, Inc. (a) | | 1,283,891 | 11,131,335 |
HCA Holdings, Inc. | | 114,000 | 20,952,060 |
Surgery Partners, Inc. (a) | | 284,584 | 6,659,266 |
The Oncology Institute, Inc. (a)(d) | | 282,701 | 1,308,906 |
| | | 40,051,567 |
Health Care Services - 8.5% | | | |
agilon health, Inc. (a)(b) | | 850,000 | 19,907,000 |
Cigna Corp. | | 162,500 | 45,088,875 |
Guardant Health, Inc. (a) | | 88,900 | 4,785,487 |
LifeStance Health Group, Inc. (a) | | 660,000 | 4,369,200 |
Oak Street Health, Inc. (a)(b) | | 890,000 | 21,822,800 |
| | | 95,973,362 |
Managed Health Care - 20.4% | | | |
Alignment Healthcare, Inc. (a) | | 460,911 | 5,457,186 |
Centene Corp. (a) | | 308,000 | 23,965,480 |
Humana, Inc. | | 110,500 | 53,613,495 |
Molina Healthcare, Inc. (a) | | 50,000 | 16,492,000 |
UnitedHealth Group, Inc. | | 260,000 | 131,310,398 |
| | | 230,838,559 |
TOTAL HEALTH CARE PROVIDERS & SERVICES | | | 366,863,488 |
Health Care Technology - 0.9% | | | |
Health Care Technology - 0.9% | | | |
Definitive Healthcare Corp. (b) | | 65,000 | 1,010,100 |
Doximity, Inc. (a)(b) | | 154,000 | 4,653,880 |
Medlive Technology Co. Ltd. (c) | | 500,000 | 569,705 |
Phreesia, Inc. (a) | | 165,000 | 4,204,200 |
| | | 10,437,885 |
Life Sciences Tools & Services - 15.1% | | | |
Life Sciences Tools & Services - 15.1% | | | |
10X Genomics, Inc. (a) | | 60,000 | 1,708,800 |
Agilent Technologies, Inc. | | 26,000 | 3,160,300 |
Bio-Rad Laboratories, Inc. Class A (a) | | 14,000 | 5,839,960 |
Bruker Corp. | | 200,000 | 10,612,000 |
Danaher Corp. | | 255,000 | 65,863,950 |
Lonza Group AG | | 14,000 | 6,816,478 |
Olink Holding AB ADR (a) | | 160,000 | 1,942,400 |
Sartorius Stedim Biotech | | 12,800 | 3,926,231 |
Seer, Inc. (a) | | 141,809 | 1,097,602 |
Stevanato Group SpA | | 169,000 | 2,862,860 |
Thermo Fisher Scientific, Inc. | | 109,000 | 55,283,710 |
West Pharmaceutical Services, Inc. | | 46,000 | 11,319,680 |
| | | 170,433,971 |
Personal Products - 0.4% | | | |
Personal Products - 0.4% | | | |
The Beauty Health Co. (a)(b) | | 142,300 | 1,677,717 |
The Beauty Health Co. (a)(d) | | 200,000 | 2,358,000 |
| | | 4,035,717 |
Pharmaceuticals - 13.0% | | | |
Pharmaceuticals - 13.0% | | | |
Arvinas Holding Co. LLC (a) | | 70,000 | 3,114,300 |
AstraZeneca PLC (United Kingdom) | | 200,000 | 21,985,897 |
Bristol-Myers Squibb Co. | | 95,000 | 6,753,550 |
Eli Lilly & Co. | | 210,000 | 67,903,500 |
Pharvaris BV (a) | | 80,000 | 642,400 |
Roche Holding AG (participation certificate) | | 44,000 | 14,323,442 |
Royalty Pharma PLC | | 715,000 | 28,728,700 |
Theseus Pharmaceuticals, Inc. | | 80,000 | 464,000 |
UCB SA | | 36,000 | 2,498,323 |
| | | 146,414,112 |
Specialty Retail - 0.2% | | | |
Specialty Stores - 0.2% | | | |
Warby Parker, Inc. (a)(b) | | 180,000 | 2,401,200 |
TOTAL COMMON STOCKS (Cost $828,404,315) | | | 1,110,194,340 |
| | | |
Convertible Preferred Stocks - 1.1% |
| | Shares | Value ($) |
Biotechnology - 0.6% | | | |
Biotechnology - 0.6% | | | |
Asimov, Inc. Series B (a)(d)(e) | | 13,047 | 797,694 |
Caris Life Sciences, Inc. Series D (a)(d)(e) | | 398,133 | 2,229,545 |
Cleerly, Inc. Series C (d)(e) | | 179,891 | 2,119,224 |
Element Biosciences, Inc. Series C (a)(d)(e) | | 72,178 | 985,951 |
ElevateBio LLC Series C (a)(d)(e) | | 31,200 | 142,678 |
Inscripta, Inc. Series E (a)(d)(e) | | 157,568 | 958,013 |
| | | 7,233,105 |
Health Care Providers & Services - 0.0% | | | |
Health Care Services - 0.0% | | | |
dMed Biopharmaceutical Co. Ltd. Series C (a)(d)(e) | | 45,182 | 405,283 |
Health Care Technology - 0.3% | | | |
Health Care Technology - 0.3% | | | |
Aledade, Inc.: | | | |
Series B1 (a)(d)(e) | | 24,966 | 1,243,556 |
Series E1 (d)(e) | | 10,776 | 536,753 |
Omada Health, Inc. Series E (d)(e) | | 281,490 | 737,504 |
Wugen, Inc. Series B (a)(d)(e) | | 57,585 | 300,594 |
| | | 2,818,407 |
Pharmaceuticals - 0.2% | | | |
Pharmaceuticals - 0.2% | | | |
Aristea Therapeutics, Inc. Series B (a)(d)(e) | | 123,100 | 1,088,204 |
Galvanize Therapeutics Series B (d)(e) | | 505,495 | 859,342 |
| | | 1,947,546 |
TOTAL CONVERTIBLE PREFERRED STOCKS (Cost $15,381,796) | | | 12,404,341 |
| | | |
Fiscal year to date information regarding the Fund's investments in Fidelity Central Funds, including the ownership percentage, is presented below.
Amounts in the income column in the above table include any capital gain distributions from underlying funds.
Amount for Fidelity Securities Lending Cash Central Fund represents the income earned on investing cash collateral, less rebates paid to borrowers and any lending agent fees associated with the loan, plus any premium payments received for lending certain types of securities.
Investments are valued as of 4:00 p.m. Eastern time on the last calendar day of the period. Securities transactions are accounted for as of trade date. The Board of Trustees (the Board) has delegated the day to day responsibility for the valuation of the Fund's investments to the Fair Value Committee (the Committee) established by the Fund's investment adviser. In accordance with valuation policies and procedures approved by the Board, the Fund attempts to obtain prices from one or more third party pricing vendors or brokers to value its investments. When current market prices, quotations or currency exchange rates are not readily available or reliable, investments will be fair valued in good faith by the Committee, in accordance with procedures adopted by the Board. Factors used in determining fair value vary by investment type and may include market or investment specific events. The frequency with which these procedures are used cannot be predicted and they may be utilized to a significant extent. The Committee oversees the Fund's valuation policies and procedures and reports to the Board on the Committee's activities and fair value determinations. The Board monitors the appropriateness of the procedures used in valuing the Fund's investments and ratifies the fair value determinations of the Committee.
The inputs to valuation techniques used to value investments are categorized into a disclosure hierarchy consisting of three levels as shown below:
Level 2 - other significant observable inputs (including quoted prices for similar investments, interest rates, prepayment speeds, etc.)
Level 3 - unobservable inputs (including the Fund's own assumptions based on the best information available)
Investments in any open-end mutual funds are valued at their closing net asset value (NAV) each business day and are categorized as Level 1 in the hierarchy.
Changes in valuation techniques may result in transfers in or out of an assigned level within the disclosure hierarchy.
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