Vaxart (VXRT) 10-K 25 Feb 21 2020 FY Annual report Financial data

Document And Entity Information

Document And Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2020	Feb. 24, 2021	Jun. 30, 2020
Document Information [Line Items]
Entity Registrant Name	Vaxart, Inc.
Entity Central Index Key	0000072444
Trading Symbol	vxrt
Current Fiscal Year End Date	--12-31
Entity Filer Category	Large Accelerated Filer
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Well-known Seasoned Issuer	Yes
Entity Emerging Growth Company	false
Entity Small Business	false
Entity Interactive Data Current	Yes
Entity Common Stock, Shares Outstanding (in shares)		117,766,672
Entity Public Float			$ 842,046,746
Entity Shell Company	false
Document Type	10-K
Document Period End Date	Dec. 31, 2020
Document Fiscal Year Focus	2020
Document Fiscal Period Focus	FY
Amendment Flag	false
Title of 12(b) Security	Common stock, $0.0001 par value

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Current assets:
Cash and cash equivalents	$ 126,870	$ 13,526
Accounts receivable	334	3,619
Prepaid expenses and other current assets	1,327	453
Total current assets	128,531	17,598
Property and equipment, net	1,480	210
Right-of-use assets, net	6,838	1,990
Intangible assets, net	15,361	17,093
Other long-term assets	372	141
Total assets	152,582	37,032
Current liabilities:
Accounts payable	2,133	852
Current portion of operating lease liability	2,052	841
Liability related to sale of future royalties, current portion	2,779	2,916
Other accrued current liabilities	4,799	4,565
Total current liabilities	11,763	9,174
Operating lease liability, net of current portion	5,156	1,472
Liability related to sale of future royalties, net of current portion	12,150	13,416
Other long-term liabilities	109	18
Total liabilities	29,178	24,080
Commitments and contingencies (Note 11)
Stockholders’ equity:
Preferred Stock: $0.0001 par value; 5,000,000 shares authorized; none issued and outstanding as of December 31, 2020 or 2019
Common Stock: $0.0001 par value; 150,000,000 shares authorized; 110,271,093 and 48,254,994 shares issued and outstanding as of December 31, 2020 and 2019, respectively	11	5
Additional paid-in capital	272,274	129,608
Accumulated deficit	(148,881)	(116,661)
Total stockholders’ equity	123,404	12,952
Total liabilities and stockholders’ equity	$ 152,582	$ 37,032

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parentheticals) - $ / shares	Dec. 31, 2020	Dec. 31, 2019
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized (in shares)	5,000,000	5,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	150,000,000	150,000,000
Common stock, shares issued (in shares)	110,271,093	48,254,994
Common stock, shares outstanding (in shares)	110,271,093	48,254,994

Consolidated Statements of Oper

Consolidated Statements of Operations and Comprehensive Loss - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenue:
Revenue	$ 4,046,000	$ 9,862,000	$ 4,159,000
Operating expenses:
Research and development	19,863,000	14,540,000	17,275,000
General and administrative	15,202,000	6,187,000	6,681,000
Impairment of intangible assets			1,600,000
Costs of exit from leased premises			359,000
Restructuring charges and (reversals)	(849,000)	4,920,000
Total operating expenses	34,216,000	25,647,000	25,915,000
Operating loss	(30,170,000)	(15,785,000)	(21,756,000)
Other income and (expenses):
Bargain purchase gain			6,760,000
Interest income	75,000	149,000	58,000
Interest expense		(315,000)	(821,000)
Non-cash interest expense related to sale of future royalties	(1,874,000)	(2,073,000)	(1,859,000)
Gain (loss) on sale of equipment		1,000	(11,000)
Loss on revaluation of financial instruments			(3,000)
Loss on debt extinguishment		(100,000)
Foreign exchange loss, net	(13,000)	(32,000)	(266,000)
Loss before provision for income taxes	(31,982,000)	(18,155,000)	(17,898,000)
Provision for income taxes	238,000	490,000	109,000
Net loss	(32,220,000)	(18,645,000)	(18,007,000)
Series B and C preferred dividend			(339,000)
Net comprehensive loss attributable to common stockholders	$ (32,220,000)	$ (18,645,000)	$ (18,346,000)
Net loss per share – basic and diluted (in dollars per share)	$ (0.36)	$ (0.86)	$ (2.90)
Shares used to compute net loss per share – basic and diluted (in shares)	88,295,762	21,569,523	6,316,065
Customer Service Contracts [Member]
Revenue:
Revenue	$ 198,000	$ 406,000
Government Contract [Member]
Revenue:
Revenue		(20,000)	1,344,000
Royalty [Member]
Revenue:
Revenue	2,962,000	4,446,000	1,340,000
Non Cash Royalty Revenue [Member]
Revenue:
Revenue	$ 886,000	$ 5,030,000	$ 1,475,000

Consolidated Statement of Stock

Consolidated Statement of Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Cumulative Effect, Period of Adoption, Adjusted Balance [Member]Preferred Stock [Member]	Cumulative Effect, Period of Adoption, Adjusted Balance [Member]Common Stock [Member]	Cumulative Effect, Period of Adoption, Adjusted Balance [Member]Additional Paid-in Capital [Member]	Cumulative Effect, Period of Adoption, Adjusted Balance [Member]Retained Earnings [Member]	Cumulative Effect, Period of Adoption, Adjusted Balance [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member]Preferred Stock [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member]Common Stock [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member]Additional Paid-in Capital [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member]Retained Earnings [Member]	Cumulative Effect, Period of Adoption, Adjustment [Member]	Placement Agents' Designees [Member]Common Stock [Member]	Placement Agents' Designees [Member]Additional Paid-in Capital [Member]	Placement Agents' Designees [Member]Retained Earnings [Member]	Placement Agents' Designees [Member]	Underwriters' Designees [Member]The September 2019 Offering [Member]Common Stock [Member]	Underwriters' Designees [Member]The September 2019 Offering [Member]Additional Paid-in Capital [Member]	Underwriters' Designees [Member]The September 2019 Offering [Member]Retained Earnings [Member]	Underwriters' Designees [Member]The September 2019 Offering [Member]	Underwriters' Designees [Member]The April 2019 Offering [Member]Common Stock [Member]	Underwriters' Designees [Member]The April 2019 Offering [Member]Additional Paid-in Capital [Member]	Underwriters' Designees [Member]The April 2019 Offering [Member]Retained Earnings [Member]	Underwriters' Designees [Member]The April 2019 Offering [Member]	Underwriters' Designees [Member]The March 2020 Offering [Member]Common Stock [Member]	Underwriters' Designees [Member]The March 2020 Offering [Member]Additional Paid-in Capital [Member]	Underwriters' Designees [Member]The March 2020 Offering [Member]Retained Earnings [Member]	Underwriters' Designees [Member]The March 2020 Offering [Member]	The September 2019 Offering [Member]Common Stock [Member]	The September 2019 Offering [Member]Additional Paid-in Capital [Member]	The September 2019 Offering [Member]Retained Earnings [Member]	The September 2019 Offering [Member]	The April 2019 Offering [Member]Common Stock [Member]	The April 2019 Offering [Member]Additional Paid-in Capital [Member]	The April 2019 Offering [Member]Retained Earnings [Member]	The April 2019 Offering [Member]	The March 2020 Offering [Member]Common Stock [Member]	The March 2020 Offering [Member]Additional Paid-in Capital [Member]	The March 2020 Offering [Member]Retained Earnings [Member]	The March 2020 Offering [Member]	The July 2020 Offering [Member]Common Stock [Member]	The July 2020 Offering [Member]Additional Paid-in Capital [Member]	The July 2020 Offering [Member]Retained Earnings [Member]	The July 2020 Offering [Member]	The December 2020 Offering [Member]Common Stock [Member]	The December 2020 Offering [Member]Additional Paid-in Capital [Member]	The December 2020 Offering [Member]Retained Earnings [Member]	The December 2020 Offering [Member]	Preferred Stock [Member]	Common Stock [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Balances (in shares) at Dec. 31, 2017																																															1,221,064	138,492
Balances at Dec. 31, 2017																																																	$ 41,260	$ (79,982)	$ (38,722)
Issuance of common stock upon conversion of convertible promissory notes, related parties (in shares)																																																1,571,702
Issuance of common stock upon conversion of convertible promissory notes, related parties																																																	35,577		35,577
Issuance of common stock upon conversion of convertible preferred stock (in shares)																																															(1,221,064)	1,918,543
Issuance of common stock upon conversion of convertible preferred stock
Reclassification of warrant to equity																																																	70		70
Issuance of common stock upon reverse merger (in shares)																																																3,510,439
Issuance of common stock upon reverse merger																																																$ 1	31,767		$ 31,768
Issuance of common stock upon exercise of stock options (in shares)																																																2,013			2,013
Issuance of common stock upon exercise of stock options																																																	13		$ 13
Stock-based compensation																																																	539		539
Net loss																																																		(18,007)	(18,007)
Issuance of common stock warrants to placement agents’ designees																																																	70		70
Balances (in shares) at Dec. 31, 2018		7,141,189																																														7,141,189
Balances at Dec. 31, 2018		$ 1	$ 109,226	$ (98,016)	$ 11,211				$ (27)	$ (27)																																						$ 1	109,226	(97,989)	$ 11,238
Reclassification of warrant to equity												$ 100		$ 100		$ 333		$ 333		$ 497		$ 497
Issuance of common stock upon exercise of stock options (in shares)																																																			0
Stock-based compensation																																																	627		$ 627
Net loss																																																		(18,645)	(18,645)
Issuance of common stock, net of offering costs (in shares)																																																1,200,000
Issuance of common stock, net of offering costs																																																	2,440		2,440
Issuance of common stock warrants to placement agents’ designees												$ 100		$ 100		$ 333		$ 333		$ 497		$ 497
Issuance of common stock, pre-funded warrants and common stock warrants, net of offering costs (in shares)																											925,455				26,124,828
Issuance of common stock, pre-funded warrants and common stock warrants, net of offering costs																												$ 7,741		$ 7,741	$ 3	$ 7,239		$ 7,242
Issuance of common stock upon exercise of pre-funded warrants (in shares)																																																12,265,455
Issuance of common stock upon exercise of pre-funded warrants																																																$ 1	1,225		1,226
Issuance of common stock upon exercise of common stock warrants (in shares)																																																598,067
Issuance of common stock upon exercise of common stock warrants																																																	180		180
Balances (in shares) at Dec. 31, 2019																																																48,254,994
Balances at Dec. 31, 2019																																																$ 5	129,608	(116,661)	$ 12,952
Reclassification of warrant to equity																								$ 453		$ 453
Issuance of common stock upon exercise of stock options (in shares)																																																414,676			414,676
Issuance of common stock upon exercise of stock options																																																	602		$ 602
Stock-based compensation																																																	4,358		4,358
Net loss																																																		(32,220)	(32,220)
Issuance of common stock, net of offering costs (in shares)																																							12,503,806				692,651
Issuance of common stock, net of offering costs																																							$ 1	$ 97,033		$ 97,034		$ 4,900		$ 4,900
Issuance of common stock warrants to placement agents’ designees																								$ 453		$ 453
Issuance of common stock, pre-funded warrants and common stock warrants, net of offering costs (in shares)																																			4,000,000
Issuance of common stock, pre-funded warrants and common stock warrants, net of offering costs																																				$ 8,722		$ 8,722
Issuance of common stock upon exercise of common stock warrants (in shares)																																																44,404,966
Issuance of common stock upon exercise of common stock warrants																																																$ 5	25,946		25,951
Disgorgement of short-swing profits, net of costs																																																	652		652
Balances (in shares) at Dec. 31, 2020																																																110,271,093
Balances at Dec. 31, 2020																																																$ 11	$ 272,274	$ (148,881)	$ 123,404

Consolidated Statement of Sto_2

Consolidated Statement of Stockholders' Equity (Deficit) (Parentheticals) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
The September 2019 Offering [Member]
Offering costs from issuance of common stock and warrants		$ 1,579
The April 2019 Offering [Member]
Offering costs from issuance of common stock and warrants		1,459
The March 2020 Offering [Member]
Offering costs from issuance of common stock and warrants	$ 1,278
The July 2020 Offering [Member]
Offering costs	2,966
The December 2020 Offering [Member]
Offering costs	$ 563
Offering costs		$ 560

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Cash flows from operating activities:
Net loss	$ (32,220,000)	$ (18,645,000)	$ (18,007,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Bargain purchase gain			(6,760,000)	[1]
Depreciation and amortization	2,710,000	3,596,000	3,203,000
(Gain) loss on sale of equipment		(1,000)	11,000
Impairment of intangible assets			1,600,000
Impairment of property and equipment and right-of-use assets		1,272,000	106,000
Stock-based compensation	4,358,000	627,000	539,000
Loss on revaluation of financial instruments			3,000
Non-cash interest expense		88,000	448,000
Amortization of note discount			18,000
Loss on debt extinguishment		100,000
Non-cash interest expense related to sale of future royalties	1,874,000	2,073,000	1,859,000
Non-cash revenue related to sale of future royalties	(3,277,000)	(3,482,000)	(18,000)
Change in operating assets and liabilities:
Accounts receivable	3,285,000	(1,823,000)	13,500,000
Prepaid expenses and other assets	(1,108,000)	855,000	(873,000)
Accounts payable	1,207,000	(62,000)	(3,784,000)
Accrued liabilities	(579,000)	2,312,000	(6,393,000)
Net cash used in operating activities	(23,750,000)	(13,090,000)	(14,548,000)
Cash flows from investing activities:
Purchase of property and equipment	(1,223,000)	(850,000)	(707,000)
Proceeds from sale of equipment	3,000
Cash acquired in reverse merger			25,525,000
Cash paid for fractional shares in merger			(21,000)
Purchases of short-term investments			(573,000)
Proceeds from maturities of short-term investments			1,988,000
Net cash (used in) provided by investing activities	(1,220,000)	(850,000)	26,212,000
Cash flows from financing activities:
Proceeds from issuance of common stock upon exercise of pre-funded warrants		1,226,000
Proceeds from issuance of common stock upon exercise of common stock warrants	25,951,000	180,000
Proceeds from issuance of common stock upon exercise of stock options	602,000		13,000
Disgorgement of short-swing profits, net of costs	652,000
Repayment of principal on secured promissory note payable to Oxford Finance		(3,799,000)	(1,528,000)
Repayment of short-term note			(214,000)
Net cash provided by (used in) financing activities	138,314,000	15,960,000	(1,729,000)
Net increase in cash and cash equivalents	113,344,000	2,020,000	9,935,000
Cash and cash equivalents at beginning of the period	13,526,000	11,506,000	1,571,000
Cash and cash equivalents at end of the period	126,870,000	13,526,000	11,506,000
Supplemental disclosure of cash flow information:
Interest paid		227,000	356,000
Supplemental disclosure of non-cash investing and financing activity:
Issuance of warrants to placement agents’ designees	453,000	100,000
Issuance of warrants to underwriters’ designees		830,000
Issuance of common stock upon reverse merger, net of cash paid for partial shares			31,768,000
Conversion of convertible promissory notes, related parties into common stock upon reverse merger			35,577,000
Reclassification of convertible preferred stock warrant liability to equity			70,000
Operating lease liabilities arising from obtaining right-of-use assets	5,664,000	1,929,000
Property and equipment acquired as an incentive to enter an operating lease	87,000
Acquisition of property and equipment included in accounts payable	78,000	4,000	52,000
Proceeds due for sale of property and equipment included in prepaid expenses and other current assets		3,000
Registered Direct Offering [Member]
Cash flows from financing activities:
Net proceeds from issuance of common stock	9,175,000	2,540,000
ATM Program [Member]
Cash flows from financing activities:
Net proceeds from issuance of common stock	101,934,000
The April 2019 Offering [Member]
Cash flows from financing activities:
Net proceeds from issuance of common stock, pre-funded warrants and common warrants in underwritten offering		8,074,000
The September 2019 Offering [Member]
Cash flows from financing activities:
Net proceeds from issuance of common stock, pre-funded warrants and common warrants in underwritten offering		$ 7,739,000
[1]	The bargain purchase gain represents the excess of the fair value of tangible and identified intangible assets acquired, less liabilities assumed, over the purchase price.

Note 1 - Organization and Basis

Note 1 - Organization and Basis of Presentation	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Organization, Consolidation and Presentation of Financial Statements Disclosure [Text Block]	NOTE 1. General Vaxart Biosciences, Inc. was originally incorporated in California in March 2004, July 2007, On February 13, 2018, 0.22148 Immediately following the completion of the Merger, the Company effected a reverse stock split at a ratio of one eleven Immediately after the Reverse Stock Split there were approximately 7.1 51% 49% 0.0201346 On March 20, 2019, “March 2019 1,200,000 $3.0 $2.5 $320,000. 84,000 March 2019 one $3.125 five March 2019 $100,000 12 On April 11, 2019, “April 2019 925,455 8,165,455 10,454,546 1,363,636 $1.10, $1.00, $0.10. one $0.10, one $1.10, five Pursuant to the terms of an underwriting agreement, the Company paid the underwriters aggregate commissions and reimbursable costs of $750,000. 636,364 April 2019 one $1.375 five $333,000 12 The total gross proceeds from the April 2019 $9.3 $8.1 December 31, 2020, $0.8 8,165,455 $11.3 10,228,580 $0.7 524,433 April 2019 On September 30, 2019, “September 2019 26,124,828 3,558,161 4,000,000 4,100,000 30,666,667 4,000,000 $0.30, $0.20, $0.10. one $0.10, one $0.30, five Pursuant to the terms of an underwriting agreement, the Company paid the underwriters aggregate commissions and reimbursable costs of $713,000. 2,115,738 September 2019 one $0.375 five $497,000 12 The total gross proceeds from the September 2019 $8.7 $7.7 December 31, 2020, $0.4 4,100,000 $9.2 30,661,667 $0.7 1,890,941 September 2019 On March 2, 2020, “March 2020 4,000,000 2,000,000 one $2.50, five $775,000. 280,000 March 2020 one $3.125 five March 2020 $453,000 12 The total gross proceeds from the offering to the Company were $10.0 $9.2 December 31, 2020, $4.2 1,683,416 10,504 March 2020 On June 8, 2020, $0.10 $0.0001 100,000,000 150,000,000. On July 13, 2020, 12,503,806 $100.0 July 8, 2020. $97.0 On October 13, 2020, may $250 $0.3 October 13, 2020, 4.5% December 31, 2020, 692,651 $5.5 $4.9 The Company's principal operations are based in South San Francisco, California, and it operates in one

Note 2 - Summary of Significant

Note 2 - Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Significant Accounting Policies [Text Block]	NOTE 2. Basis of Presentation Basis of Consolidation Use of Estimates Foreign Currencies no Cash and Cash Equivalents three may Concentration of Credit Risk not The primary focus of the Company's investment strategy is to preserve capital and meet liquidity requirements. The Company's investment policy addresses the level of credit exposure by limiting the concentration in any one no Accounts Receivable 6 no December 31, 2020 2019 Property and Equipment The useful lives of the property and equipment are as follows: Laboratory equipment (in years) 5 Office and computer equipment (in years) 3 Leasehold improvements Shorter of remaining lease term or estimated useful life Intangible Assets 5 1.3 11.75 20 not December 31, 2018 ( 5 Impairment of Long-Lived Assets may not December 31, 2018 ( 5 8 December 31, 2019 ( 15 Accrued Clinical and Manufacturing Expenses third not The Company estimates the amount of services provided through discussions with internal personnel and external service providers as to the progress or stage of completion of the services and the agreed-upon fee to be paid for such services. The Company makes significant judgments and estimates in determining the accrued balance in each reporting period. As actual costs become known, it adjusts its accrued estimates. Although the Company does not may third not Leases January 1, 2019, one not not Convertible Preferred Stock Warrant Liability no Revenue Recognition five (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated selling prices; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account. Revenue from royalties earned as a percentage of sales, including milestone payments based on achieving a specified level of sales, where a license is deemed to be the predominant item to which the royalties relate, is recognized as revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied), as required under the sales- and usage-based royalty exception. Revenue from contracts with customers is recognized ratably, based on costs incurred, as the Company provides promised services to its customers in amounts that reflect the consideration that the Company expects to receive for those services. The Company performed research and development work under its cost-plus-fixed-fee contract with HHS BARDA. The Company recognizes revenue under research contracts only when a contract has been executed and the contract price is fixed or determinable. Revenue from the HHS BARDA contract is recognized in the period during which the related costs are incurred and the related services are rendered, provided that the applicable conditions under the contract have been met. Costs of contract revenue are recorded as a component of operating expenses in the consolidated statements of operations and comprehensive loss. Under cost reimbursable contracts, the Company recognizes revenue as allowable costs are incurred and the fixed fee is earned. Reimbursable costs under the contract primarily include direct labor, subcontract costs, materials, equipment, travel, and approved overhead and indirect costs. Fixed fees under cost reimbursable contracts are earned in proportion to the allowable costs incurred in performance of the work relative to total estimated contract costs, with such costs incurred representing a reasonable measurement of the proportional performance of the work completed. Payments to the Company under cost reimbursable contracts, such as this contract, are provisional payments subject to adjustment upon annual audit by the government. Management believes that revenue for periods not may Research and Development Costs third Stock-Based Compensation April 1, 2018, April 1, 2018, Net Income (Loss) Per Share Attributable to Common Stockholders Diluted net income (loss) per common share is computed giving effect to all potential dilutive common shares, comprising common stock issuable upon exercise of stock options and warrants. The Company uses the treasury-stock method to compute diluted income (loss) per share with respect to its stock options and warrants. For purposes of this calculation, options and warrants to purchase common stock are considered to be potential common shares and are only included in the calculation of diluted net income per share when their effect is dilutive. In the event of a net loss, the effects of all potentially dilutive shares are excluded from the diluted net loss per share calculation as their inclusion would be antidilutive. Reclassification Prior year data is subject to reclassification to conform to current year presentation. Recently Adopted Accounting Pronouncements The Company did not 2020. Recent Accounting Pronouncements In August 2020, 2020 06, Debt - Debt with Conversion and Other Options (Subtopic 470 20 815 40 none January 1, 2021. The Company has reviewed all other significant newly-issued accounting pronouncements that are not not not

Note 3 - Business Combination

Note 3 - Business Combination	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Business Combination Disclosure [Text Block]	NOTE 3. On February 13, 2018, 1 2 Since the date of the Merger, the results of Aviragen's operations have been included in the consolidated financial statements. As a result of the acquisition, the Company eliminated the majority of its debt and acquired a significant cash balance in exchange for equity securities. The total purchase price for Aviragen is summarized as follows (in thousands): Common stock $ 31,789 Total $ 31,789 In connection with the Aviragen acquisition, the Company allocated the total purchase consideration to the net assets and liabilities acquired, including identifiable intangible assets, based on their respective fair values at the acquisition date. The following table summarizes the preliminary allocation of the purchase price to the fair value of the respective assets and liabilities acquired, adjustments made since the acquisition date and the final allocation as of December 31, 2018 ( As of February 13, 2018 2018 Adjustments As of December 31, 2018 Cash and cash equivalents $ 25,525 $ — $ 25,525 Accounts receivable 14,666 — 14,666 Prepaid expenses 446 (10 ) 436 Property and equipment 170 — 170 Intangible assets: Developed technology (1) 22,400 (300 ) 22,100 In-process research and development (2) 1,600 — 1,600 Total assets 64,807 (310 ) 64,497 Accounts payable (3,379 ) 75 (3,304 ) Other current liabilities (6,351 ) (393 ) (6,744 ) Liability related to sale of future royalties (16,300 ) 400 (15,900 ) Net assets acquired 38,777 (228 ) 38,549 Purchase price (31,789 ) — (31,789 ) Bargain purchase gain (3) $ 6,988 $ (228 ) $ 6,760 ( 1 Developed technology comprises Inavir and Relenza, both influenza vaccines on which the Company is, or was, receiving royalty revenue, which, based on valuations prepared by an independent third 11.75 1.3 ( 2 In-process research and development (see Note 5 BTA074, third ( 3 The bargain purchase gain represents the excess of the fair value of tangible and identified intangible assets acquired, less liabilities assumed, over the purchase price.

Note 4 - Fair Value of Financia

Note 4 - Fair Value of Financial Instruments	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Fair Value Disclosures [Text Block]	NOTE 4. Fair Value of Financial Instruments Fair value accounting is applied for all financial assets and liabilities and nonfinancial assets and liabilities that are recognized or disclosed at fair value in the financial statements on a recurring basis (at least annually). Financial instruments include cash and cash equivalents, accounts receivable, accounts payable and accrued liabilities that approximate fair value due to their relatively short maturities. Assets and liabilities recorded at fair value on a recurring basis in the balance sheets are categorized based upon the level of judgment associated with inputs used to measure their fair values. The accounting guidance for fair value provides a framework for measuring fair value and requires certain disclosures about how fair value is determined. Fair value is defined as the price that would be received to sell an asset or paid to transfer a liability (an exit price) in an orderly transaction between market participants at the reporting date. The accounting guidance also establishes a three The three Level 1 Level 2 not Level 3 no The Company's money market funds are classified within Level 1 3 The Company's only recurring financial assets that are measured at fair value were $60,005,000, $15,000 $15,000 December 31, 2020, 2019 2018, no December 31, 2020 2019. 3 December 31, 2018 ( Convertible Preferred Stock Warrant Liability Total Balance at January 1, 2018 $ 67 $ 67 Issuances — — Revaluation loss included in loss on revaluation of financial instruments 3 3 Settlements (70 ) (70 ) Balance at December 31, 2018 $ — $ — Total losses included in other income and (expenses) attributable to liabilities still held as of December 31, 2018 $ — $ —

Note 5 - Balance Sheet Componen

Note 5 - Balance Sheet Components	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Supplemental Balance Sheet Disclosures [Text Block]	NOTE 5. (a) Cash and Cash Equivalents Cash and cash equivalents comprises the following (in thousands): December 31, 2020 December 31, 2019 Cash at banks $ 66,865 $ 13,511 Money market funds 60,005 15 Cash and cash equivalents $ 126,870 $ 13,526 (b) Accounts Receivable Accounts receivable comprises the following (in thousands): December 31, 2020 December 31, 2019 Royalties receivable $ 334 $ 3,438 Customer service contracts – billed — 181 Accounts receivable $ 334 $ 3,619 (c) Property and Equipment, Net Property and equipment, net consists of the following (in thousands): December 31, 2020 December 31, 2019 Laboratory equipment $ 1,759 $ 537 Office and computer equipment 294 132 Total property and equipment 2,053 669 Less: accumulated depreciation (573 ) (459 ) Property and equipment, net $ 1,480 $ 210 Depreciation expense was $114,000, $504,000 $476,000 December 31, 2020, 2019 2018 one 15 December 31, 2019, $1,152,000 November 2018, 8 September 30, 2018, $106,000 (d) Right-of-Use Assets, Net Right-of-use assets consist of the following (in thousands): December 31, 2020 December 31, 2019 Facilities $ 6,836 $ 1,985 Office equipment 2 5 Right-of-use assets, net $ 6,838 $ 1,990 The right of use of one 15 December 31, 2019, $120,000 (e) Intangible Assets, Net Intangible assets comprise developed technology, intellectual property and, until it was considered fully impaired, in-process research and development. Intangible assets are carried at cost less accumulated amortization. Amortization is computed using the straight-line method over useful lives ranging from 1.3 11.75 20 December 31, 2020, 8.9 7.0 December 31, 2020 December 31, 2019 Purchased technology $ 20,300 $ 22,100 Intellectual property 80 80 Total cost 20,380 22,180 Less accumulated amortization (5,019 ) (5,087 ) Intangible assets, net $ 15,361 $ 17,093 Intangible asset amortization expense was $1,732,000, $2,320,000 $2,727,000 December 31, 2020, 2019 2018 2 June 2018, three June 30, 2018, $1.6 3 As of December 31, 2020 Year Ending December 31, Amount 2021 $ 1,732 2022 1,731 2023 1,732 2024 1,732 2025 1,731 Thereafter 6,703 Total $ 15,361 (f) Other Accrued Liabilities Other accrued liabilities consist of the following (in thousands): December 31, 2020 December 31, 2019 Accrued compensation $ 1,618 $ 903 Accrued clinical and manufacturing expenses 1,772 3,228 Accrued professional and consulting services 777 2 Reserve for return of royalties — 178 Other 632 254 Total $ 4,799 $ 4,565

Note 6 - Revenue

Note 6 - Revenue	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Revenue [Text Block]	NOTE 6. Service Contracts with Customers Contract Balances. December 31, 2020 2019, nil $181,000, December 31, 2020 2019, $219,000 $21,000, Remaining Performance Obligations. December 31, 2020 2019, no $13,000 $211,000, not 100% December 31, 2020, three not not U.S. Government HHS BARDA Contract In September 2015, May 25 July 18, 2017, June 28, 2018, $14 $1.7 September 30, 2018. $15.7 $1,344,000 December 31, 2018, $20,000 December 31, 2019. December 31, 2020 $20,000 no Billings under the contract are based on approved provisional indirect billing rates, which permit recovery of fringe benefits, overhead and general and administrative expenses. Indirect rates as well as allowable costs are subject to audit by HHS BARDA on an annual basis. Management believes that revenues recognized to date have been recorded in amounts that are expected to be realized upon final audit and settlement. When the final determination of the allowable costs for any year has been made, revenue and billings may three December 31, 2019, $20,000 2018 may not December 31, 2020, Royalty agreements Aviragen entered into a royalty-bearing research and license agreement with GlaxoSmithKline, plc (“GSK”) in 1990 July 2019 2020, 2019, 2018, $193,000, $778,000 $788,000, 7% The Company also generates royalty revenue from the sale of Inavir in Japan, pursuant to a collaboration and license agreement that Aviragen entered into with Daiichi Sankyo Company, Limited (“Daiichi Sankyo”), in 2009. September 2010, 4% December 2029 2020, 2019, 2018, $2,769,000, $3,668,000 $552,000, 7 $886,000, $5,030,000 $1,475,000 2020, 2019 2018, 5% $183,000, $435,000 $102,000 December 31, 2020, 2019 2018,

Note 7 - Liabilities Related to

Note 7 - Liabilities Related to Sale of Future Royalties	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Liabilities Related to Sale of Future Royalties [Text Block]	NOTE 7. Liabilities Related to Sale of Future Royalties In April 2016, $20.0 first $3.0 15% $1.0 April 1, Under the relevant accounting guidance, due to a limit on the amount of royalties that HCRP can earn under the RIAA, this transaction was accounted for as a liability that is being amortized using the effective interest method over the life of the arrangement. The Company has no not not The following table shows the activity within the liability account during the year ended December 31, 2020 ( Total liability related to sale of future royalties, start of year $ 16,332 Non-cash royalty revenue paid to HCRP (3,277 ) Non-cash interest expense recognized 1,874 Total liability related to sale of future royalties, end of year 14,929 Current portion (2,779 ) Long-term portion $ 12,150

Note 8 - Leases

Note 8 - Leases	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Lessee, Operating Leases [Text Block]	NOTE 8. The Company has obtained the right of use for office and manufacturing facilities under six one one three one The Company obtained the right of use of real estate located in South San Francisco, California, in November 2020 September 30, 2025, no June 2015 April 30, 2020, five July 2019, April 30, 2025. December 31, 2019 ( 15 February 2018, February 28, 2021, no November 30, 2018. two July 31, 2021, no September 2021. 2022. As of December 31, 2020, one 9.94% 4.07 The following table summarizes the Company's undiscounted cash payment obligations for its operating lease liabilities with initial terms of more than twelve December 31, 2020 ( Year Ending December 31, Amount 2021 $ 2,633 2022 1,801 2023 1,585 2024 1,641 2025 1,112 Undiscounted total 8,772 Less: imputed interest (1,564 ) Present value of future minimum payments 7,208 Current portion of operating lease liability (2,052 ) Operating lease liability, net of current portion $ 5,156 The Company presently has no no one Certain operating lease agreements for facilities include non-lease costs, such as common area maintenance, which are recorded as variable lease costs. Operating lease expenses for the years ended December 31, 2020 2019, Year Ended December 31, 2020 2019 Lease cost Operating lease cost $ 1,145 $ 959 Short-term lease cost 13 15 Variable lease cost 264 162 Sublease income (217 ) (217 ) Total lease cost $ 1,205 $ 919 Net cash outflows associated with operating leases totaled $1,111,000 $983,000 December 31, 2020 2019, When the Company subleased its facilities located in Alpharetta, Georgia, for less than it is required to pay under the head lease, it recorded a lease loss charge of $253,000 three December 31, 2018, 5 Liabilities related to costs of exit from leased premises are summarized as follows (in thousands): Balance as of January 1, 2018 $ — Costs of exit from leased premises 359 Deferred rent on cease-use date 19 Impairment of property and equipment (106 ) Cash paid, net of receipts (41 ) Accretion charges, included in rent expense 2 Balance as of December 31, 2018 $ 233 Prior to December 31, 2018, $875,000 December 31, 2018.

Note 9 - Convertible Promissory

Note 9 - Convertible Promissory Notes, Related Parties	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Convertible Promissory Notes, Related Party [Text Block]	NOTE 9. On December 10, 2014, December 2014 $18.4 On November 20, 2015, second November December 2015 $11.0 2014. As the holders of the convertible promissory notes each had an equity ownership in the Company, the convertible promissory notes were considered to be a related-party transaction. The convertible promissory notes bore interest at a rate of 8.0% As of December 31, 2017, $35.3 $29.4 $6.3 $0.4 $0.3 December 31, 2018, 43 On February 13, 2018, $35.6 $29.4 $6.6 $0.4 1,571,702 $9.05, $14.2 $21.4

Note 10 - Secured Promissory No

Note 10 - Secured Promissory Note Payable to Oxford Finance	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Secured Promissory Note Payable [Text Block]	NOTE 10. On December 22, 2016, $5.0 $5.0 30 6.17%, four first 12 36 In conjunction with the execution of the Loan Agreement, all the holders of convertible promissory notes signed subordination agreements, under which they agreed to subordinate in favor of Oxford Finance all amounts due under their promissory notes and any security interest in the Company's property. In addition, the holders of the notes agreed that they would not $325,000 In connection with the Loan Agreement, the Company issued a warrant to Oxford Finance to purchase 7,563 $33.11 $134,000 The Warrant provided that if the share price at the next equity financing was less than the Warrant exercise price, then the Warrant would be for the new class of shares, the exercise price would be the new class share price, and the number of shares would be calculated by dividing $250,000 Due to the antidilution protection, following the Merger, the Warrant was amended to allow the holder to purchase 10,914 $22.99 no $70,000 February 13, 2018, 4 The annual effective interest rate of the note, including the accretion of the final payment and the amortization of the debt discount, was approximately 10.5%. $311,000 $526,000 December 31, 2019 2018, $223,000 $356,000 November 4, 2019. $98,000 $2,000 VAXART, INC. AND SUBSIDIARIES Notes to the Consolidated Financial Statements

Note 11 - Commitments and Conti

Note 11 - Commitments and Contingencies	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Commitments and Contingencies Disclosure [Text Block]	NOTE 11. (a) Purchase Commitments As of December 31, 2020 $24.6 eighteen Note 8 (b) Indemnifications In the ordinary course of business, the Company enters into agreements that may may third not may (c) From time to time the Company may not On August 4, 2020, September 4, 2020, second November 25, 2020. second March 24, 2020 June 15, 2020 two June 8, 2020. second no December 30, 2020, second On September 8, 2020, October 20, 2020, March 24, 2020 June 15, 2020 two June 8, 2020. no no October 9, 2020, November 12, 2020, In re Vaxart, Inc. Stockholder Litigation Jaquith v. Latour January 4, 2021, On September 17, 2020, §14 1934 April 24, 2020, March 24, 2020 June 15, 2020, June 8, 2020, no no no November 13, 2020, Two substantially similar securities class actions were filed in the U.S. District Court for the Northern District of California, the first, titled Himmelberg v. Vaxart, Inc. et al. was filed on August 24, 2020 ( second September 1, 2020 ( September 17, 2020, one December 9, 2020, January 29, 2021, two 10b 5, 20 20A OWS On October 23, 2020, 16 no On January 8, 2021, pro se Chan v. Vaxart, Inc. et al. Opt-Out Action two 10 10b 5, 20 19 On February 4, 2021, Barker v. Vaxart, Inc. et al one 141 not The Company's legal costs incurred in its defense against these claims are expensed as incurred.

Note 12 - Stockholders' Equity

Note 12 - Stockholders' Equity	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Stockholders' Equity Note Disclosure [Text Block]	NOTE 12. (a) Convertible Preferred Stock The Company is authorized to issue 5,000,000 $0.0001 may, 5,000,000 one may No no February 13, 2018, three 1 Series C 2013 $20.0 8%. not no February 13, 2018, $7.3 $188,000 2018. February 13, 2018, 696,028 253,851 Series B 2009 2014 $16.0 8%. not no February 13, 2018, $7.6 $151,000 2018. February 13, 2018, 599,259 265,340 Series A 2007 2012 $2.9 No February 13, 2018, 104,065 (b) Common Stock Except as otherwise required by law or as otherwise provided in any certificate of designation for any series of preferred stock, the holders of common stock possess all voting power for the election of the Company's directors and all other matters requiring stockholder action. Holders of common stock are entitled to one may no December 31, 2020 no In the event of the Company's voluntary or involuntary liquidation, dissolution, distribution of assets or winding-up, the holders of the common stock will be entitled to receive an equal amount per share of all the Company's assets of whatever kind available for distribution to stockholders, after the rights of the holders of the preferred stock have been satisfied. There are no The Company had shares of common stock reserved for issuance as follows: December 31, 2020 December 31, 2019 Options issued and outstanding 6,813,033 1,811,652 Available for future grants of equity awards 1,230,863 295,180 Common stock warrants 1,244,974 43,370,162 Total 9,288,870 45,476,994 (c) Warrants The Company has the following warrants outstanding as of December 31, 2020 none Securities into which warrants are convertible Warrants outstanding Exercise Price Expiration Date Common Stock 5,000 $ 0.30 September 2024 Common Stock 224,797 $ 0.375 September 2024 Common Stock 225,966 $ 1.10 April 2024 Common Stock 111,931 $ 1.375 April 2024 Common Stock 316,584 $ 2.50 March 2025 Common Stock 269,496 $ 3.125 February 2025 Common Stock 80,286 $ 3.125 March 2024 Common Stock 10,914 $ 22.99 December 2026 Total 1,244,974 The aggregate fair value at issuance of the warrants issued to the placement agents' designees at the closing of the March 2019 March 2020 April 2019 September 2019 1 $100,000, $453,000, $333,000 $497,000, Offering March 2019 April 2019 September 2019 March 2020 Aggregate valuation on issuance date $ 100,000 $ 333,000 $ 497,000 $ 453,000 Number of warrants issued 84,000 636,364 2,115,738 280,000 Exercise price $ 3.125 $ 1.375 $ 0.375 $ 3.125 Closing stock price $ 2.08 $ 0.89 $ 0.36 $ 2.34 Risk-free interest rate 2.34 % 2.31 % 1.55 % 0.88 % Expected term (In Years) 5.00 5.00 5.00 4.99 Expected volatility 80 % 83 % 83 % 98 % Dividend yield — % — % — % — % In the event of a Fundamental Transaction (a transfer of ownership of the Company as defined in the warrant) within the Company's control, the holders of the unexercised common stock warrants exercisable for $0.30, $0.375, $1.10 $2.50 $3.125 February 2025 not

Note 13 - Equity Incentive Plan

Note 13 - Equity Incentive Plans	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Share-based Payment Arrangement [Text Block]	NOTE 13. Prior to the Merger, Private Vaxart issued equity awards for compensation purposes to employees, directors and consultants under the Company's 2007 “2007 2007 July 2017 no may 2007 In November 2016, 2016 “2016 2016 2016 ten 2019 “2019 no 2016 On April 23, 2019, 2019 may 2019 may The aggregate number of shares of common stock authorized for issuance under the 2019 1,600,000 2019 June 8, 2020, 8,000,000 2019 2019 ten may A summary of stock option transactions in each of the three December 31, 2020 Weighted Shares Number of Average Available Options Exercise For Grant Outstanding Price Balance at January 1, 2018 — 304,850 $ 9.50 Assumed on consummation of Merger 291,102 627,106 $ 26.33 Granted (431,100 ) 431,100 $ 5.17 Exercised — (2,013 ) $ 6.49 Forfeited 71,500 (89,903 ) $ 5.90 Canceled 269,148 (405,977 ) $ 34.64 Balance at December 31, 2018 200,650 865,163 $ 8.13 Authorized under 2019 Plan on Adoption 1,600,000 — $ — Removed from 2016 Plan (223,389 ) — $ — Granted (1,791,030 ) 1,791,030 $ 0.67 Forfeited 483,849 (592,528 ) $ 1.57 Canceled 25,100 (252,013 ) $ 9.25 Balance at December 31, 2019 295,180 1,811,652 $ 2.74 Authorized under 2019 Plan Amendment 6,400,000 — $ — Granted (5,579,800 ) 5,579,800 $ 2.66 Exercised — (414,676 ) $ 1.45 Forfeited 105,910 (105,992 ) $ 1.65 Canceled 9,573 (57,751 ) $ 10.57 Balance at December 31, 2020 1,230,863 6,813,033 $ 2.70 As of December 31, 2020 6,813,033 $2.70, 8.99 $22.5 6,502,213 $2.68, 8.97 $21.6 2,886,541 $2.65, 8.65 $9.9 The aggregate intrinsic value represents the total pre-tax value (i.e., the difference between the Company's stock price and the exercise price) of stock options outstanding as of December 31, 2020 $5.71, The intrinsic value of options exercised in the year ended December 31, 2020 $2.2 no December 31, 2019 December 31, 2018, zero In March 2020, 411,000 December 31, 2020, $1.70 September 30, 2020, $632,000 nine September 30, 2020. December 31, 2020, not 411,000 On March 24, 2020, 2,610,000 $1.70 March 24, 2020) ( “March 25% twenty-four 24 May 1, 2020 April 1, 2022; not June 8, 2020, March On June 15, 2020, 900,000 845,280 $2.46 25% first 75% three first 50% 2019 Vesting of the performance-based options would occur if the Company achieved a specified closing price during any ten November 30, 2020, one third $5.00, one third $7.50 one third $10.00, $2.46, 105%, 0.35%, zero 5.23 $0.31 $279,000, November 30, 2020, $5.00, $7.50 $10.00 July 9, 2020, July 20, 2020 July 24, 2020, June 30, 2020, three September 30, 2020. Excluding these performance-based options, the weighted average grant date fair value of options awarded in the years ended December 31, 2020, 2019 2018 $2.49, $0.48 $3.59, Year Ended December 31, 2020 2019 2018 Risk-free interest rate 0.40% 0.88% 1.68% 2.31% 2.79% 2.80% Expected term (in years) 5.22 10.00 5.39 10.00 5.84 6.05 Expected volatility 94% 111% 83% 85% 78% 80% Dividend yield —% —% —% The Company measures the fair value of all stock-based awards on the grant date and records the fair value of these awards, net of estimated forfeitures, to compensation expense over the service period. Total stock-based compensation recognized for options was as follows (in thousands): Year Ended December 31, 2020 2019 2018 Research and development $ 1,563 $ 253 $ 254 General and administrative 2,795 374 285 Total stock-based compensation $ 4,358 $ 627 $ 539 As of December 31, 2020 $8.2 2.31

Note 14 - Related Party Transac

Note 14 - Related Party Transactions	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Related Party Transactions Disclosure [Text Block]	NOTE 14. In April 2020, $652,000 16 1934,

Note 15 - Restructuring Charges

Note 15 - Restructuring Charges and (Reversals)	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Restructuring and Related Activities Disclosure [Text Block]	NOTE 15. Restructuring liabilities primarily consisted of the estimated future obligations for contract suspension costs and severance and benefits obligations. These restructuring liabilities, all of which were paid in the year ending December 31, 2020, The Company approved a reduction-in-force during the year ended December 31, 2019, three March 31, 2020. $2,252,000 September 2020 no December 31, 2020, not Cumulative restructuring costs incurred and a reconciliation of the change in related liabilities during the years ended December 31, 2019 2020, Suspension Severance Impairment of Contract Benefits Charges Other Total Cumulative cost incurred as of December 31, 2020 $ 2,252 $ 368 $ 1,272 $ 179 $ 4,071 Reconciliation of liabilities: Balance at January 1, 2019 $ — $ — $ — $ — $ — Period charges 3,223 368 1,272 57 4,920 Settlements — — (1,272 ) — (1,272 ) Balance at December 31, 2019 3,223 368 — 57 3,648 Period charges — — — 122 122 Period reversals (971 ) — — — (971 ) Settlements (2,252 ) (368 ) — (179 ) (2,799 ) Balance at December 31, 2020 $ — $ — $ — $ — $ —

Note 16 - Benefit Plan

Note 16 - Benefit Plan	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Retirement Benefits [Text Block]	NOTE 16. The Company provides a tax-qualified employee savings and retirement plan commonly known as a 401 may $19,500 2020, $19,000 2019 $18,500 2018. 50 may $6,500 $6,000 2019 2018. Employees direct their contributions, which vest immediately, across a series of mutual funds. In the years ended December 31, 2020, 2019 2018, 3% $96,000, $140,000 $124,000 December 31, 2020, 2019 2018, $10,000, $14,000 $9,000 December 31, 2020, 2019 2018,

Note 17 - Income Taxes

Note 17 - Income Taxes	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Income Tax Disclosure [Text Block]	NOTE 17. The provision for income taxes consists of the following (in thousands): Year Ended December 31, 2020 2019 2018 Current: Federal $ — $ — $ — State 3 2 3 Foreign 235 488 106 Total Current 238 490 109 Deferred: Federal — — — State — — — Foreign — — — Total Deferred — — — Provision for income taxes $ 238 $ 490 $ 109 The components of the deferred tax assets are as follows (in thousands): December 31, 2020 December 31, 2019 December 31, 2018 Deferred tax assets: Net operating loss carry-forwards $ 14,161 $ 6,924 $ 43,822 Research and development tax credits 2,497 1,591 3,357 Capitalized research and development 4,534 4,773 2,326 Sale of future royalties 7,178 7,486 8,383 Lease Liability 1,695 492 — Accruals, reserves and other 1,327 1,253 714 Total deferred tax assets 31,392 22,519 58,602 Valuation allowance (21,952 ) (13,365 ) (48,626 ) Deferred tax assets net of valuation allowance 9,440 9,154 9,976 Deferred tax liabilities: Intangible assets (7,832 ) (8,730 ) (9,976 ) Right-of-use assets (1,608 ) (424 ) — Total deferred tax liabilities (9,440 ) (9,154 ) (9,976 ) Net deferred tax assets $ — $ — $ — A reconciliation of the provision for income taxes with the expected provision for income taxes computed by applying the federal statutory income tax rate of 21% Year Ended December 31, 2020 2019 2018 U.S. federal taxes at statutory rate 21.0 % 21.0 % 21.0 % State taxes (net of federal benefit) 2.9 0.4 0.6 Foreign rate differential (0.7 ) (2.6 ) 3.1 Global intangible low-taxed income — — (8.8 ) Permanently non-deductible items 2.2 (3.7 ) (2.5 ) Tax credits 2.8 1.7 2.1 Change in valuation allowance (26.8 ) 194.2 (20.4 ) Tax attributes write-off due to change in control 0.5 (208.3 ) — Prior year true-up (2.5 ) (0.9 ) — NOL and credit adjustments — — (3.8 ) Bargain purchase gain — — 8.1 Other (0.1 ) (4.5 ) — Provision for income taxes (0.7 )% (2.7 )% (0.6 )% The Company's actual tax expense differed from the statutory federal income tax expense using a tax rate of 21% December 31, 2019, December 31, 2020, 2019 2018 21% As of December 31, 2020, 2019 2018 $51.6 $18.0 $92.3 $26.8 $1.6 $76.9 not 2024 2028 2019 As of December 31, 2020 $6.8 not may not December 31, 2020 no no As of December 31, 2020, 2019 2018 $0.9 $0.1 $3.0 $3.4 $2.7 $2.3 2039, not Sections 382 383 may February 13, 2018, December 31, 2020, not September 30, 2019, $62,000, May 15, 2020, $3.2 382 383 not The Company is required to reduce its deferred tax assets by a valuation allowance if it is more likely than not not December 31, 2020, 2019 2018 $8.6 December 31, 2020, $35.3 December 31, 2019 $25.7 December 31, 2018. 2019 September 30, 2019. The Company records unrecognized tax benefits, where appropriate, for all uncertain income tax positions. The Company recorded unrecognized tax benefits for uncertain tax positions of approximately $1.3 December 31, 2020 none A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands): Year Ended December 31, 2020 2019 2018 Beginning Balance $ 851 $ 1,582 $ 1,404 Additions based on tax positions related to the current year 431 159 181 Decreases related to prior years' tax positions (1 ) (890 ) (3 ) Ending Balance $ 1,281 $ 851 $ 1,582 The Company's policy is to recognize interest and penalties accrued on any unrecognized tax benefits as a component of income tax expense. During the years ended December 31, 2020, 2019 2018 no no twelve The Company files income tax returns in the U.S. and Australia, as well as with various U.S. states. The Company is subject to tax audits in all jurisdictions in which it files income tax returns. Tax audits by their very nature are often complex and can require several years to complete. There are currently no Under the tax statute of limitations applicable to the Internal Revenue Code, the Company and its U.S. subsidiary, either standalone or as part of the consolidated group, is no 2017. no 2016 2015

Note 18 - Net Loss Per Share At

Note 18 - Net Loss Per Share Attributable to Common Stockholders	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Earnings Per Share [Text Block]	NOTE 18. The following table presents the calculation of basic and diluted net loss per share (in thousands, except share and per share amounts): Year Ended December 31, 2020 2019 2018 Net loss $ (32,220 ) $ (18,645 ) $ (18,007 ) Series B and C preferred dividend — — (339 ) Net loss attributable to common stockholders $ (32,220 ) $ (18,645 ) $ (18,346 ) Shares used to compute net loss per share, basic and diluted 88,295,762 21,569,523 6,316,065 Net loss per share attributable to common stockholders, basic and diluted $ (0.36 ) $ (0.86 ) $ (2.90 ) No The following potentially dilutive securities were excluded from the computation of diluted weighted average shares outstanding because they would have been antidilutive: Year Ended December 31, 2020 2019 2018 Options to purchase common stock 4,409,806 1,583,575 839,396 Warrants to purchase common stock 14,773,425 17,579,945 9,658 Warrant to purchase convertible preferred stock — — 891 Series B and C convertible preferred stock outstanding, including cumulative dividends — — 213,760 Series A convertible preferred stock outstanding — — 12,260 Convertible promissory notes, related party (as converted) — — 185,159 Total potentially dilutive securities excluded from denominator of the diluted earnings per share computation 19,183,231 19,163,520 1,261,124

Note 19 - Quarterly Financial D

Note 19 - Quarterly Financial Data (Unaudited)	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Quarterly Financial Information [Text Block]	NOTE 19. Selected summarized quarterly financial information for each of the last three Year Ended December 31, 2020 First Second Third Fourth Revenue $ 2,902 $ 523 $ 265 $ 356 Operating expenses $ 3,596 $ 9,049 $ 7,854 $ 13,717 Net loss $ (1,297 ) $ (8,977 ) $ (8,085 ) $ (13,861 ) Net loss per share – basic and diluted $ (0.02 ) $ (0.12 ) $ (0.08 ) $ (0.13 ) Year Ended December 31, 2019 First Second Third Fourth Revenue $ 5,407 $ 85 $ 454 $ 3,916 Operating expenses $ 5,855 $ 5,082 $ 5,168 $ 9,542 Net loss $ (1,339 ) $ (5,637 ) $ (5,260 ) $ (6,409 ) Net loss per share – basic and diluted $ (0.18 ) $ (0.39 ) $ (0.32 ) $ (0.13 ) Year Ended December 31, 2018 First Second Third Fourth Revenue $ 1,503 $ 608 $ 281 $ 1,767 Operating expenses $ 5,418 $ 8,383 $ 6,161 $ 5,953 Net income (loss) $ 2,314 $ (8,871 ) $ (6,548 ) $ (4,902 ) Net income (loss) attributable to common stockholders $ 1,975 $ (8,871 ) $ (6,548 ) $ (4,902 ) Net income (loss) per share – basic $ 0.54 $ (1.24 ) $ (0.92 ) $ (0.69 ) Net income (loss) per share – diluted $ 0.49 $ (1.24 ) $ (0.92 ) $ (0.69 )

Note 20 - Subsequent Events

Note 20 - Subsequent Events	12 Months Ended
	Dec. 31, 2020
Notes to Financial Statements
Subsequent Events [Text Block]	NOTE 20. Since December 31, 2020, 6,654,367 1 $65.8 830,722 $1.6 Changes in the status of litigation since December 31, 2020, 11. Litigation

Significant Accounting Policies

Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2020
Accounting Policies [Abstract]
Basis of Accounting, Policy [Policy Text Block]	Basis of Presentation
Consolidation, Policy [Policy Text Block]	Basis of Consolidation
Use of Estimates, Policy [Policy Text Block]	Use of Estimates
Foreign Currency Transactions and Translations Policy [Policy Text Block]	Foreign Currencies no
Cash and Cash Equivalents, Policy [Policy Text Block]	Cash and Cash Equivalents three may
Concentration Risk, Credit Risk, Policy [Policy Text Block]	Concentration of Credit Risk not The primary focus of the Company's investment strategy is to preserve capital and meet liquidity requirements. The Company's investment policy addresses the level of credit exposure by limiting the concentration in any one no
Receivable [Policy Text Block]	Accounts Receivable 6 no December 31, 2020 2019
Property, Plant and Equipment, Policy [Policy Text Block]	Property and Equipment The useful lives of the property and equipment are as follows: Laboratory equipment (in years) 5 Office and computer equipment (in years) 3 Leasehold improvements Shorter of remaining lease term or estimated useful life
Goodwill and Intangible Assets, Intangible Assets, Policy [Policy Text Block]	Intangible Assets 5 1.3 11.75 20 not December 31, 2018 ( 5
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]	Impairment of Long-Lived Assets may not December 31, 2018 ( 5 8 December 31, 2019 ( 15
Accrued Clinical And Manufacturing Expenses Policy [Policy Text Block]	Accrued Clinical and Manufacturing Expenses third not The Company estimates the amount of services provided through discussions with internal personnel and external service providers as to the progress or stage of completion of the services and the agreed-upon fee to be paid for such services. The Company makes significant judgments and estimates in determining the accrued balance in each reporting period. As actual costs become known, it adjusts its accrued estimates. Although the Company does not may third not
Lessee, Leases [Policy Text Block]	Leases January 1, 2019, one not not
Derivatives, Policy [Policy Text Block]	Convertible Preferred Stock Warrant Liability no
Revenue [Policy Text Block]	Revenue Recognition five (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations based on estimated selling prices; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. A performance obligation is a promise in a contract to transfer a distinct good or service to the customer and is the unit of account. Revenue from royalties earned as a percentage of sales, including milestone payments based on achieving a specified level of sales, where a license is deemed to be the predominant item to which the royalties relate, is recognized as revenue at the later of (i) when the related sales occur, or (ii) when the performance obligation to which some or all of the royalty has been allocated has been satisfied (or partially satisfied), as required under the sales- and usage-based royalty exception. Revenue from contracts with customers is recognized ratably, based on costs incurred, as the Company provides promised services to its customers in amounts that reflect the consideration that the Company expects to receive for those services. The Company performed research and development work under its cost-plus-fixed-fee contract with HHS BARDA. The Company recognizes revenue under research contracts only when a contract has been executed and the contract price is fixed or determinable. Revenue from the HHS BARDA contract is recognized in the period during which the related costs are incurred and the related services are rendered, provided that the applicable conditions under the contract have been met. Costs of contract revenue are recorded as a component of operating expenses in the consolidated statements of operations and comprehensive loss. Under cost reimbursable contracts, the Company recognizes revenue as allowable costs are incurred and the fixed fee is earned. Reimbursable costs under the contract primarily include direct labor, subcontract costs, materials, equipment, travel, and approved overhead and indirect costs. Fixed fees under cost reimbursable contracts are earned in proportion to the allowable costs incurred in performance of the work relative to total estimated contract costs, with such costs incurred representing a reasonable measurement of the proportional performance of the work completed. Payments to the Company under cost reimbursable contracts, such as this contract, are provisional payments subject to adjustment upon annual audit by the government. Management believes that revenue for periods not may
Research and Development Expense, Policy [Policy Text Block]	Research and Development Costs third
Share-based Payment Arrangement [Policy Text Block]	Stock-Based Compensation April 1, 2018, April 1, 2018,
Earnings Per Share, Policy [Policy Text Block]	Net Income (Loss) Per Share Attributable to Common Stockholders Diluted net income (loss) per common share is computed giving effect to all potential dilutive common shares, comprising common stock issuable upon exercise of stock options and warrants. The Company uses the treasury-stock method to compute diluted income (loss) per share with respect to its stock options and warrants. For purposes of this calculation, options and warrants to purchase common stock are considered to be potential common shares and are only included in the calculation of diluted net income per share when their effect is dilutive. In the event of a net loss, the effects of all potentially dilutive shares are excluded from the diluted net loss per share calculation as their inclusion would be antidilutive.
Reclassification, Comparability Adjustment [Policy Text Block]	Reclassification Prior year data is subject to reclassification to conform to current year presentation.
New Accounting Pronouncements, Policy [Policy Text Block]	Recently Adopted Accounting Pronouncements The Company did not 2020. Recent Accounting Pronouncements In August 2020, 2020 06, Debt - Debt with Conversion and Other Options (Subtopic 470 20 815 40 none January 1, 2021. The Company has reviewed all other significant newly-issued accounting pronouncements that are not not not

Note 2 - Summary of Significa_2

Note 2 - Summary of Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Property, Plant, and Equipment, Useful Life [Table Text Block]	Laboratory equipment (in years) 5 Office and computer equipment (in years) 3 Leasehold improvements Shorter of remaining lease term or estimated useful life

Note 3 - Business Combination (

Note 3 - Business Combination (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Business Acquisitions by Acquisition, Equity Interest Issued or Issuable [Table Text Block]	Common stock $ 31,789 Total $ 31,789
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed [Table Text Block]	As of February 13, 2018 2018 Adjustments As of December 31, 2018 Cash and cash equivalents $ 25,525 $ — $ 25,525 Accounts receivable 14,666 — 14,666 Prepaid expenses 446 (10 ) 436 Property and equipment 170 — 170 Intangible assets: Developed technology (1) 22,400 (300 ) 22,100 In-process research and development (2) 1,600 — 1,600 Total assets 64,807 (310 ) 64,497 Accounts payable (3,379 ) 75 (3,304 ) Other current liabilities (6,351 ) (393 ) (6,744 ) Liability related to sale of future royalties (16,300 ) 400 (15,900 ) Net assets acquired 38,777 (228 ) 38,549 Purchase price (31,789 ) — (31,789 ) Bargain purchase gain (3) $ 6,988 $ (228 ) $ 6,760

Note 4 - Fair Value of Financ_2

Note 4 - Fair Value of Financial Instruments (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Table Text Block]	Convertible Preferred Stock Warrant Liability Total Balance at January 1, 2018 $ 67 $ 67 Issuances — — Revaluation loss included in loss on revaluation of financial instruments 3 3 Settlements (70 ) (70 ) Balance at December 31, 2018 $ — $ — Total losses included in other income and (expenses) attributable to liabilities still held as of December 31, 2018 $ — $ —

Note 5 - Balance Sheet Compon_2

Note 5 - Balance Sheet Components (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Cash and Cash Equivalents [Table Text Block]	December 31, 2020 December 31, 2019 Cash at banks $ 66,865 $ 13,511 Money market funds 60,005 15 Cash and cash equivalents $ 126,870 $ 13,526
Schedule of Accounts, Notes, Loans and Financing Receivable [Table Text Block]	December 31, 2020 December 31, 2019 Royalties receivable $ 334 $ 3,438 Customer service contracts – billed — 181 Accounts receivable $ 334 $ 3,619
Property, Plant and Equipment [Table Text Block]	December 31, 2020 December 31, 2019 Laboratory equipment $ 1,759 $ 537 Office and computer equipment 294 132 Total property and equipment 2,053 669 Less: accumulated depreciation (573 ) (459 ) Property and equipment, net $ 1,480 $ 210
Lessee, Operating Lease, Right-of-Use Assets [Table Text Block]	December 31, 2020 December 31, 2019 Facilities $ 6,836 $ 1,985 Office equipment 2 5 Right-of-use assets, net $ 6,838 $ 1,990
Schedule of Finite-Lived Intangible Assets [Table Text Block]	December 31, 2020 December 31, 2019 Purchased technology $ 20,300 $ 22,100 Intellectual property 80 80 Total cost 20,380 22,180 Less accumulated amortization (5,019 ) (5,087 ) Intangible assets, net $ 15,361 $ 17,093
Schedule of Finite-Lived Intangible Assets, Future Amortization Expense [Table Text Block]	Year Ending December 31, Amount 2021 $ 1,732 2022 1,731 2023 1,732 2024 1,732 2025 1,731 Thereafter 6,703 Total $ 15,361
Schedule of Accrued Liabilities [Table Text Block]	December 31, 2020 December 31, 2019 Accrued compensation $ 1,618 $ 903 Accrued clinical and manufacturing expenses 1,772 3,228 Accrued professional and consulting services 777 2 Reserve for return of royalties — 178 Other 632 254 Total $ 4,799 $ 4,565

Note 7 - Liabilities Related _2

Note 7 - Liabilities Related to Sale of Future Royalties (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Deferred Revenue, by Arrangement, Disclosure [Table Text Block]	Total liability related to sale of future royalties, start of year $ 16,332 Non-cash royalty revenue paid to HCRP (3,277 ) Non-cash interest expense recognized 1,874 Total liability related to sale of future royalties, end of year 14,929 Current portion (2,779 ) Long-term portion $ 12,150

Note 8 - Leases (Tables)

Note 8 - Leases (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Lessee, Operating Lease, Liability, Maturity [Table Text Block]	Year Ending December 31, Amount 2021 $ 2,633 2022 1,801 2023 1,585 2024 1,641 2025 1,112 Undiscounted total 8,772 Less: imputed interest (1,564 ) Present value of future minimum payments 7,208 Current portion of operating lease liability (2,052 ) Operating lease liability, net of current portion $ 5,156
Lease, Cost [Table Text Block]	Year Ended December 31, 2020 2019 Lease cost Operating lease cost $ 1,145 $ 959 Short-term lease cost 13 15 Variable lease cost 264 162 Sublease income (217 ) (217 ) Total lease cost $ 1,205 $ 919
Restructuring and Related Costs [Table Text Block]	Balance as of January 1, 2018 $ — Costs of exit from leased premises 359 Deferred rent on cease-use date 19 Impairment of property and equipment (106 ) Cash paid, net of receipts (41 ) Accretion charges, included in rent expense 2 Balance as of December 31, 2018 $ 233

Note 12 - Stockholders' Equity

Note 12 - Stockholders' Equity (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Common Stock Reserved for Issuance [Table Text Block]	December 31, 2020 December 31, 2019 Options issued and outstanding 6,813,033 1,811,652 Available for future grants of equity awards 1,230,863 295,180 Common stock warrants 1,244,974 43,370,162 Total 9,288,870 45,476,994
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]	Securities into which warrants are convertible Warrants outstanding Exercise Price Expiration Date Common Stock 5,000 $ 0.30 September 2024 Common Stock 224,797 $ 0.375 September 2024 Common Stock 225,966 $ 1.10 April 2024 Common Stock 111,931 $ 1.375 April 2024 Common Stock 316,584 $ 2.50 March 2025 Common Stock 269,496 $ 3.125 February 2025 Common Stock 80,286 $ 3.125 March 2024 Common Stock 10,914 $ 22.99 December 2026 Total 1,244,974
Fair Value of Warrants, Assumptions [Table Text Block]	Offering March 2019 April 2019 September 2019 March 2020 Aggregate valuation on issuance date $ 100,000 $ 333,000 $ 497,000 $ 453,000 Number of warrants issued 84,000 636,364 2,115,738 280,000 Exercise price $ 3.125 $ 1.375 $ 0.375 $ 3.125 Closing stock price $ 2.08 $ 0.89 $ 0.36 $ 2.34 Risk-free interest rate 2.34 % 2.31 % 1.55 % 0.88 % Expected term (In Years) 5.00 5.00 5.00 4.99 Expected volatility 80 % 83 % 83 % 98 % Dividend yield — % — % — % — %

Note 13 - Equity Incentive Pl_2

Note 13 - Equity Incentive Plans (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Share-based Payment Arrangement, Option, Activity [Table Text Block]	Weighted Shares Number of Average Available Options Exercise For Grant Outstanding Price Balance at January 1, 2018 — 304,850 $ 9.50 Assumed on consummation of Merger 291,102 627,106 $ 26.33 Granted (431,100 ) 431,100 $ 5.17 Exercised — (2,013 ) $ 6.49 Forfeited 71,500 (89,903 ) $ 5.90 Canceled 269,148 (405,977 ) $ 34.64 Balance at December 31, 2018 200,650 865,163 $ 8.13 Authorized under 2019 Plan on Adoption 1,600,000 — $ — Removed from 2016 Plan (223,389 ) — $ — Granted (1,791,030 ) 1,791,030 $ 0.67 Forfeited 483,849 (592,528 ) $ 1.57 Canceled 25,100 (252,013 ) $ 9.25 Balance at December 31, 2019 295,180 1,811,652 $ 2.74 Authorized under 2019 Plan Amendment 6,400,000 — $ — Granted (5,579,800 ) 5,579,800 $ 2.66 Exercised — (414,676 ) $ 1.45 Forfeited 105,910 (105,992 ) $ 1.65 Canceled 9,573 (57,751 ) $ 10.57 Balance at December 31, 2020 1,230,863 6,813,033 $ 2.70
Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]	Year Ended December 31, 2020 2019 2018 Risk-free interest rate 0.40% 0.88% 1.68% 2.31% 2.79% 2.80% Expected term (in years) 5.22 10.00 5.39 10.00 5.84 6.05 Expected volatility 94% 111% 83% 85% 78% 80% Dividend yield —% —% —%
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]	Year Ended December 31, 2020 2019 2018 Research and development $ 1,563 $ 253 $ 254 General and administrative 2,795 374 285 Total stock-based compensation $ 4,358 $ 627 $ 539

Note 15 - Restructuring Charg_2

Note 15 - Restructuring Charges and (Reversals) (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Restructuring Reserve by Type of Cost [Table Text Block]	Suspension Severance Impairment of Contract Benefits Charges Other Total Cumulative cost incurred as of December 31, 2020 $ 2,252 $ 368 $ 1,272 $ 179 $ 4,071 Reconciliation of liabilities: Balance at January 1, 2019 $ — $ — $ — $ — $ — Period charges 3,223 368 1,272 57 4,920 Settlements — — (1,272 ) — (1,272 ) Balance at December 31, 2019 3,223 368 — 57 3,648 Period charges — — — 122 122 Period reversals (971 ) — — — (971 ) Settlements (2,252 ) (368 ) — (179 ) (2,799 ) Balance at December 31, 2020 $ — $ — $ — $ — $ —

Note 17 - Income Taxes (Tables)

Note 17 - Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]	Year Ended December 31, 2020 2019 2018 Current: Federal $ — $ — $ — State 3 2 3 Foreign 235 488 106 Total Current 238 490 109 Deferred: Federal — — — State — — — Foreign — — — Total Deferred — — — Provision for income taxes $ 238 $ 490 $ 109
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]	December 31, 2020 December 31, 2019 December 31, 2018 Deferred tax assets: Net operating loss carry-forwards $ 14,161 $ 6,924 $ 43,822 Research and development tax credits 2,497 1,591 3,357 Capitalized research and development 4,534 4,773 2,326 Sale of future royalties 7,178 7,486 8,383 Lease Liability 1,695 492 — Accruals, reserves and other 1,327 1,253 714 Total deferred tax assets 31,392 22,519 58,602 Valuation allowance (21,952 ) (13,365 ) (48,626 ) Deferred tax assets net of valuation allowance 9,440 9,154 9,976 Deferred tax liabilities: Intangible assets (7,832 ) (8,730 ) (9,976 ) Right-of-use assets (1,608 ) (424 ) — Total deferred tax liabilities (9,440 ) (9,154 ) (9,976 ) Net deferred tax assets $ — $ — $ —
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]	Year Ended December 31, 2020 2019 2018 U.S. federal taxes at statutory rate 21.0 % 21.0 % 21.0 % State taxes (net of federal benefit) 2.9 0.4 0.6 Foreign rate differential (0.7 ) (2.6 ) 3.1 Global intangible low-taxed income — — (8.8 ) Permanently non-deductible items 2.2 (3.7 ) (2.5 ) Tax credits 2.8 1.7 2.1 Change in valuation allowance (26.8 ) 194.2 (20.4 ) Tax attributes write-off due to change in control 0.5 (208.3 ) — Prior year true-up (2.5 ) (0.9 ) — NOL and credit adjustments — — (3.8 ) Bargain purchase gain — — 8.1 Other (0.1 ) (4.5 ) — Provision for income taxes (0.7 )% (2.7 )% (0.6 )%
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block]	Year Ended December 31, 2020 2019 2018 Beginning Balance $ 851 $ 1,582 $ 1,404 Additions based on tax positions related to the current year 431 159 181 Decreases related to prior years' tax positions (1 ) (890 ) (3 ) Ending Balance $ 1,281 $ 851 $ 1,582

Note 18 - Net Loss Per Share _2

Note 18 - Net Loss Per Share Attributable to Common Stockholders (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]	Year Ended December 31, 2020 2019 2018 Net loss $ (32,220 ) $ (18,645 ) $ (18,007 ) Series B and C preferred dividend — — (339 ) Net loss attributable to common stockholders $ (32,220 ) $ (18,645 ) $ (18,346 ) Shares used to compute net loss per share, basic and diluted 88,295,762 21,569,523 6,316,065 Net loss per share attributable to common stockholders, basic and diluted $ (0.36 ) $ (0.86 ) $ (2.90 )
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]	Year Ended December 31, 2020 2019 2018 Options to purchase common stock 4,409,806 1,583,575 839,396 Warrants to purchase common stock 14,773,425 17,579,945 9,658 Warrant to purchase convertible preferred stock — — 891 Series B and C convertible preferred stock outstanding, including cumulative dividends — — 213,760 Series A convertible preferred stock outstanding — — 12,260 Convertible promissory notes, related party (as converted) — — 185,159 Total potentially dilutive securities excluded from denominator of the diluted earnings per share computation 19,183,231 19,163,520 1,261,124

Note 19 - Quarterly Financial_2

Note 19 - Quarterly Financial Data (Unaudited) (Tables)	12 Months Ended
	Dec. 31, 2020
Notes Tables
Quarterly Financial Information [Table Text Block]	Year Ended December 31, 2020 First Second Third Fourth Revenue $ 2,902 $ 523 $ 265 $ 356 Operating expenses $ 3,596 $ 9,049 $ 7,854 $ 13,717 Net loss $ (1,297 ) $ (8,977 ) $ (8,085 ) $ (13,861 ) Net loss per share – basic and diluted $ (0.02 ) $ (0.12 ) $ (0.08 ) $ (0.13 ) Year Ended December 31, 2019 First Second Third Fourth Revenue $ 5,407 $ 85 $ 454 $ 3,916 Operating expenses $ 5,855 $ 5,082 $ 5,168 $ 9,542 Net loss $ (1,339 ) $ (5,637 ) $ (5,260 ) $ (6,409 ) Net loss per share – basic and diluted $ (0.18 ) $ (0.39 ) $ (0.32 ) $ (0.13 ) Year Ended December 31, 2018 First Second Third Fourth Revenue $ 1,503 $ 608 $ 281 $ 1,767 Operating expenses $ 5,418 $ 8,383 $ 6,161 $ 5,953 Net income (loss) $ 2,314 $ (8,871 ) $ (6,548 ) $ (4,902 ) Net income (loss) attributable to common stockholders $ 1,975 $ (8,871 ) $ (6,548 ) $ (4,902 ) Net income (loss) per share – basic $ 0.54 $ (1.24 ) $ (0.92 ) $ (0.69 ) Net income (loss) per share – diluted $ 0.49 $ (1.24 ) $ (0.92 ) $ (0.69 )

Note 1 - Organization and Bas_2

Note 1 - Organization and Basis of Presentation (Details Textual)	Oct. 13, 2020USD ($)	Jul. 13, 2020USD ($)shares	Mar. 02, 2020USD ($)$ / sharesshares	Sep. 30, 2019USD ($)$ / sharesshares	Apr. 11, 2019USD ($)$ / sharesshares	Mar. 20, 2019USD ($)$ / sharesshares	Feb. 13, 2018shares	Dec. 31, 2020USD ($)$ / sharesshares	Dec. 31, 2020USD ($)$ / sharesshares	Dec. 31, 2020USD ($)$ / sharesshares	Dec. 31, 2019USD ($)$ / sharesshares	Dec. 31, 2018USD ($)	Dec. 31, 2020USD ($)$ / sharesshares	Dec. 31, 2020USD ($)$ / sharesshares	Jun. 08, 2020$ / sharesshares	Jun. 07, 2020$ / sharesshares
Business Combination, Stock Conversion, Shares Issued Per Common Share Of Surviving Entity (in shares)							0.22148
Stock Issued During Period, Shares, Reverse Stock Splits (in shares)							7,100,000
Exchange Ratio, Number of Shares Exchanged Per Share (in shares)							0.0201346
Stock Issued During Period, Shares, New Issues (in shares)						1,200,000
Gross Proceeds from Issuance of Common Stock | $						$ 3,000,000
Proceeds from Issuance of Common Stock | $						2,500,000
Payments of Stock Issuance Costs | $						$ 320,000
Payments for Aggregate Commissions to Underwriters | $					$ 750,000
Proceeds From Exercise of Pre-funded Warrants | $											$ 1,226,000
Common Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares								$ 0.0001	$ 0.0001	$ 0.0001	$ 0.0001		$ 0.0001	$ 0.0001	$ 0.0001	$ 0.10
Common Stock, Shares Authorized (in shares)								150,000,000	150,000,000	150,000,000	150,000,000		150,000,000	150,000,000	150,000,000	100,000,000
Stock Issued During Period, Value, New Issues | $											$ 2,440,000
The April 2019 Offering [Member]
Stock Issued During Period, Shares, New Issues, Excluding Shares Sold to Underwriters (in shares)					925,455
Shares Issued, Price Per Share (in dollars per share) | $ / shares					$ 1.10
Proceeds from Issuance or Sale of Equity, Total | $					$ 9,300,000
Proceeds from Issuance or Sale of Equity, Net | $					$ 8,100,000
The September 2019 Offering [Member]
Stock Issued During Period, Shares, New Issues, Excluding Shares Sold to Underwriters (in shares)				26,124,828
Shares Issued, Price Per Share (in dollars per share) | $ / shares				$ 0.30
Pre-funded Warrant Price (in dollars per share) | $ / shares				0.20
Pre-funded Warrant, Accompanying Warrant, Amount Paid Per Share (in dollars per share) | $ / shares				$ 0.10
Payments for Aggregate Commissions to Underwriters | $				$ 713,000
Proceeds from Issuance or Sale of Equity, Total | $				8,700,000
Proceeds from Issuance or Sale of Equity, Net | $				$ 7,700,000
The March 2020 Offering [Member]
Stock Issued During Period, Shares, New Issues (in shares)			4,000,000
Payments of Stock Issuance Costs | $			$ 775,000
Proceeds from Issuance or Sale of Equity, Total | $			10,000,000
Proceeds from Issuance or Sale of Equity, Net | $			$ 9,200,000
ATM Program [Member]
Stock Issued During Period, Shares, New Issues (in shares)		12,503,806
Proceeds from Issuance of Common Stock | $		$ 97,000,000								$ 101,934,000
Stock Issued During Period, Value, New Issues | $		$ 100,000,000
Open Market Sale Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)								692,651
Proceeds from Issuance of Common Stock | $								$ 4,900,000
Payments of Stock Issuance Costs | $	$ 300,000
Stock Issued During Period, Value, New Issues | $								$ 5,500,000
Open Market Sale Agreement, Maximum Aggregate Offering Price | $	$ 250,000,000
Open Market Sale Agreement, Sales Commission, Percentage	4.50%
Warrants in Connection with March 2019 Offering [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)						84,000
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)						1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares						$ 3.125
Warrants and Rights Outstanding, Term (Year)						5 years
Warrants and Rights Outstanding | $						$ 100,000
Warrants in Connection With the April 2019 Offering [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					10,454,546
Warrants and Rights Outstanding | $					$ 333,000
Class of Warrant Right, Number of Pre-funded Warrants Issued During Period (in shares)					8,165,455
Pre-funded Warrant Price (in dollars per share) | $ / shares					$ 1
Pre-funded Warrant, Accompanying Warrant, Amount Paid Per Share (in dollars per share) | $ / shares					$ 0.10
Warrants in Connection With the April 2019 Offering [Member] | Over-Allotment Option [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)					1,363,636
Pre-funded Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)				1	1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares				$ 0.10	$ 0.10
Class of Warrant Right, Number of Pre-funded Warrants Issued During Period (in shares)				4,100,000
Proceeds From Exercise of Pre-funded Warrants | $													$ 400,000	$ 800,000
Class of Warrant or Right, Exercised During Period (in shares)													4,100,000	8,165,455
Common Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)				1	1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares				$ 0.30	$ 1.10
Warrants and Rights Outstanding, Term (Year)				5 years	5 years
Class of Warrant or Right, Exercised During Period (in shares)													30,661,667	10,228,580
Proceeds from Exercise of Common Stock Warrants | $													$ 9,200,000	$ 11,300,000
Underwriter Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)					1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares					$ 1.375
Class of Warrant or Right, Issued During Period (in shares)					636,364
Class of Warrant or Right, Period to Expiration (Year)					5 years
Class of Warrant or Right, Issued During Period, Fair Value | $					$ 333,000
Class of Warrant or Right, Exercised During Period (in shares)														524,433
Proceeds from Exercise of Common Stock Warrants | $														$ 700,000
Warrants in Connection with the September 2019 Offering [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)				30,666,667
Warrants and Rights Outstanding | $				$ 497,000
Warrants in Connection with the September 2019 Offering [Member] | Over-Allotment Option [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)				4,000,000
Underwriter Warrants, September 2019 [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)				1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares				$ 0.375
Warrants and Rights Outstanding | $				$ 497,000
Class of Warrant or Right, Issued During Period (in shares)				2,115,738
Class of Warrant or Right, Period to Expiration (Year)				5 years
Class of Warrant or Right, Exercised During Period (in shares)													1,890,941
Proceeds from Exercise of Common Stock Warrants | $													$ 700,000
The March 2020 Offering Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)			2,000,000
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)			1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 2.50
Warrants and Rights Outstanding, Term (Year)			5 years
Warrants and Rights Outstanding | $			$ 453,000
Class of Warrant or Right, Exercised During Period (in shares)									1,683,416
Proceeds from Exercise of Common Stock Warrants | $									$ 4,200,000
The March 2020 Offering Placement Agent Warrants [Member]
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right (in shares)			1
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share) | $ / shares			$ 3.125
Warrants and Rights Outstanding | $			$ 453,000
Class of Warrant or Right, Issued During Period (in shares)			280,000
Class of Warrant or Right, Exercised During Period (in shares)									10,504
Private Vaxart's Stockholders, Warrantholders, and Optionholders [Member]
Ownership Percentage							51.00%
Aviragens Stockholderrs and Optionholders [Member]
Ownership Percentage							49.00%
Reverse Stock Split [Member]
Stockholders' Equity Note, Stock Split, Conversion Ratio							11

Note 2 - Summary of Significa_3

Note 2 - Summary of Significant Accounting Policies (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Accounts Receivable, Allowance for Credit Loss, Ending Balance	$ 0	$ 0
Developed Technology Rights [Member] | Minimum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	1 year 109 days
Developed Technology Rights [Member] | Maximum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	11 years 273 days
Intellectual Property [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	20 years

Note 2 - Summary of Significa_4

Note 2 - Summary of Significant Accounting Policies - Estimated Useful Lives (Details)	12 Months Ended
	Dec. 31, 2020
Laboratory Equipment [Member]
Laboratory equipment (in years) (Year)	5 years
Office Equipment [Member]
Laboratory equipment (in years) (Year)	3 years
Leasehold Improvements [Member]
Leasehold improvements	Shorter of remaining lease term or estimated useful life

Note 3 - Business Combination_2

Note 3 - Business Combination (Details Textual) - Developed Technology Rights [Member]	12 Months Ended
	Dec. 31, 2020
Maximum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	11 years 273 days
Minimum [Member]
Finite-Lived Intangible Asset, Useful Life (Year)	1 year 109 days

Note 3 - Business Combination -

Note 3 - Business Combination - Total Purchase Price for Aviragen (Details) - USD ($) $ in Thousands	Feb. 13, 2018	Dec. 31, 2018
Common stock	$ 31,789
Total	$ 31,789	$ 31,789

Note 3 - Business Combination_3

Note 3 - Business Combination - Allocation of the Purchase Price to the Fair Value of the Respective Assets and Liabilities Acquired (Details) - USD ($) $ in Thousands		Feb. 13, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Cash and cash equivalents					$ 25,525
Accounts receivable					14,666
Prepaid expenses					436
Property and equipment					170
Intangible assets:
Developed technology (1)	[1]				22,100
In-process research and development (2)	[2]				1,600
Total assets					64,497
Accounts payable					(3,304)
Other current liabilities					(6,744)
Liability related to sale of future royalties					(15,900)
Net assets acquired					38,549
Purchase price		$ (31,789)			(31,789)
Bargain purchase gain (3)					6,760	[3]
Previously Reported [Member]
Cash and cash equivalents		25,525
Accounts receivable		14,666
Prepaid expenses		446
Property and equipment		170
Intangible assets:
Developed technology (1)	[1]	22,400
In-process research and development (2)	[2]	1,600
Total assets		64,807
Accounts payable		(3,379)
Other current liabilities		(6,351)
Liability related to sale of future royalties		(16,300)
Net assets acquired		38,777
Purchase price		(31,789)
Bargain purchase gain (3)	[3]	$ 6,988
Revision of Prior Period, Adjustment [Member]
Cash and cash equivalents
Accounts receivable
Prepaid expenses					(10)
Property and equipment
Intangible assets:
Developed technology (1)	[1]				(300)
In-process research and development (2)	[2]
Total assets					(310)
Accounts payable					75
Other current liabilities					(393)
Liability related to sale of future royalties					400
Net assets acquired					(228)
Purchase price
Bargain purchase gain (3)	[3]				$ (228)
[1]	Developed technology comprises Inavir and Relenza, both influenza vaccines on which the Company is, or was, receiving royalty revenue, which, based on valuations prepared by an independent third party based on estimated discounted cash flows based on probability-weighted future development expenditures and revenue streams provided by the Company's management, are being, or has been, amortized on a straight-line basis over the estimated periods of future royalties at the time of the acquisition of 11.75 and 1.3 years, respectively.
[2]	In-process research and development (see Note 5) related to teslexivir, or BTA074, a direct-acting antiviral that, at the time of the Merger, was being actively developed as a treatment for genital warts. The valuation was prepared by an independent third party based on estimated discounted cash flows based on probability-weighted future development expenditures and revenue streams provided by the Company's management.
[3]	The bargain purchase gain represents the excess of the fair value of tangible and identified intangible assets acquired, less liabilities assumed, over the purchase price.

Note 4 - Fair Value of Financ_3

Note 4 - Fair Value of Financial Instruments (Details Textual) - Fair Value, Recurring [Member] - USD ($)	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Financial Liabilities Fair Value Disclosure, Total	$ 0	$ 0
Money Market Funds [Member]
Cash and Cash Equivalents, Fair Value Disclosure	$ 60,005,000	$ 15,000	$ 15,000

Note 4 - Fair Value of Financ_4

Note 4 - Fair Value of Financial Instruments - Reconciliation of All Liabilities Measured At Fair Value on a Recurring Basis Using Significant Unobservable Inputs (Level 3) (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2018USD ($)
Balance at January 1, 2018	$ 67
Issuances
Revaluation loss included in loss on revaluation of financial instruments	3
Settlements	(70)
Balance at December 31, 2018
Total losses included in other income and (expenses) attributable to liabilities still held as of December 31, 2018
Convertible Preferred Stock Warrant Liability [Member]
Balance at January 1, 2018	67
Issuances
Revaluation loss included in loss on revaluation of financial instruments	3
Settlements	(70)
Balance at December 31, 2018
Total losses included in other income and (expenses) attributable to liabilities still held as of December 31, 2018

Note 5 - Balance Sheet Compon_3

Note 5 - Balance Sheet Components (Details Textual) - USD ($)	3 Months Ended	9 Months Ended	12 Months Ended
	Jun. 30, 2018	Sep. 30, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Depreciation, Total			$ 114,000	$ 504,000	$ 476,000
Impairment of Property and Equipment		$ 106,000		1,272,000	106,000
Amortization of Intangible Assets, Total			1,732,000	2,320,000	2,727,000
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)					$ 1,600,000
In Process Research and Development 1 [Member]
Impairment of Intangible Assets, Indefinite-lived (Excluding Goodwill)	$ 1,600,000
Developed Technology Rights [Member]
Finite-Lived Intangible Asset, Remaining Life (Year)			8 years 328 days
Intellectual Property [Member]
Finite-Lived Intangible Asset, Useful Life (Year)			20 years
Finite-Lived Intangible Asset, Remaining Life (Year)			7 years
Minimum [Member] | Developed Technology Rights [Member]
Finite-Lived Intangible Asset, Useful Life (Year)			1 year 109 days
Maximum [Member] | Developed Technology Rights [Member]
Finite-Lived Intangible Asset, Useful Life (Year)			11 years 273 days
Restructuring Charges [Member]
Impairment of Right-of-use Asset				120,000
Restructuring Charges [Member] | CALIFORNIA
Asset Impairment Charges, Total				$ 1,152,000

Note 5 - Balance Sheet Compon_4

Note 5 - Balance Sheet Components - Cash and Cash Equivalents (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Cash at banks	$ 66,865	$ 13,511
Money market funds	60,005	15
Cash and cash equivalents	$ 126,870	$ 13,526	$ 11,506	$ 1,571

Note 5 - Balance Sheet Compon_5

Note 5 - Balance Sheet Components - Accounts Receivable, Net of Allowance (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Accounts receivable	$ 334	$ 3,619
Royalty [Member]
Accounts receivable	334	3,438
Customer Service Contracts [Member]
Accounts receivable		$ 181

Note 5 - Balance Sheet Compon_6

Note 5 - Balance Sheet Components - Property and Equipment, Net (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Property and equipment, gross	$ 2,053	$ 669
Less: accumulated depreciation	(573)	(459)
Property and equipment, net	1,480	210
Laboratory Equipment [Member]
Property and equipment, gross	1,759	537
Office Equipment [Member]
Property and equipment, gross	$ 294	$ 132

Note 5 - Balance Sheet Compon_7

Note 5 - Balance Sheet Components - Right-of-Use Assets, Net (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Right-of-use assets, net	$ 6,838	$ 1,990
Facilities [Member]
Right-of-use assets, net	6,836	1,985
Office Equipment [Member]
Right-of-use assets, net	$ 2	$ 5

Note 5 - Balance Sheet Compon_8

Note 5 - Balance Sheet Components - Intangible assets (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Intangible assets, gross	$ 20,380	$ 22,180
Less accumulated amortization	(5,019)	(5,087)
Intangible assets, net	15,361	17,093
Purchased Technology [Member]
Intangible assets, gross	20,300	22,100
Intellectual Property [Member]
Intangible assets, gross	$ 80	$ 80

Note 5 - Balance Sheet Compon_9

Note 5 - Balance Sheet Components - Estimated Future Amortization Expense (Details) $ in Thousands	Dec. 31, 2020USD ($)
2021	$ 1,732
2022	1,731
2023	1,732
2024	1,732
2025	1,731
Thereafter	6,703
Total	$ 15,361

Note 5 - Balance Sheet Compo_10

Note 5 - Balance Sheet Components - Accrued liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
Accrued compensation	$ 1,618	$ 903
Accrued clinical and manufacturing expenses	1,772	3,228
Accrued professional and consulting services	777	2
Reserve for return of royalties		178
Other	632	254
Total	$ 4,799	$ 4,565

Note 6 - Revenue 1 (Details Tex

Note 6 - Revenue 1 (Details Textual) - USD ($)	Jun. 28, 2018	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Sep. 30, 2015
Contract with Customer, Asset, after Allowance for Credit Loss, Current, Total		$ 0				$ 181,000								$ 0	$ 181,000
Contract With Customer, Asset, Revenue Recognized		219,000				21,000								219,000	21,000
Contract with Customer, Liability, Total		0				0								0	0
Revenue, Remaining Performance Obligation, Amount		13,000				211,000								13,000	211,000
Revenue from Contract with Customer, Including Assessed Tax		$ 356,000	$ 265,000	$ 523,000	$ 2,902,000	$ 3,916,000	$ 454,000	$ 85,000	$ 5,407,000	$ 1,767,000	$ 281,000	$ 608,000	$ 1,503,000	4,046,000	9,862,000	$ 4,159,000
Income Tax Expense (Benefit), Total														$ 238,000	490,000	109,000
Foreign Tax Authority [Member] | National Tax Agency, Japan [Member]
Royalty Withholding Tax														5.00%
Income Tax Expense (Benefit), Total														$ 183,000	435,000	102,000
Government Contract [Member]
Contract Value	$ 15,700,000																$ 14,000,000
Contract Value, Adjustment	$ 1,700,000
Revenue from Contract with Customer, Including Assessed Tax															(20,000)	1,344,000
Contract with Customer, Asset, Credit Loss Expense (Reversal)															20,000
Contract with Customer, Asset, Allowance for Credit Loss, Period Increase (Decrease), Total														(20,000)
Contract with Customer, Asset, Allowance for Credit Loss, Writeoff															20,000
Royalty [Member]
Revenue from Contract with Customer, Including Assessed Tax														2,962,000	4,446,000	1,340,000
Royalty [Member] | GSK Research and License Agreement [Member]
Revenue from Contract with Customer, Including Assessed Tax														$ 193,000	778,000	788,000
Royalty Percentage														7.00%
Royalty [Member] | Daiichi Sankyo Collaberation and License Agreement [Member]
Revenue from Contract with Customer, Including Assessed Tax														$ 2,769,000	3,668,000	552,000
Royalty Percentage														4.00%
Non Cash Royalty Revenue [Member]
Revenue from Contract with Customer, Including Assessed Tax														$ 886,000	5,030,000	1,475,000
Non Cash Royalty Revenue [Member] | Daiichi Sankyo Collaberation and License Agreement [Member]
Revenue from Contract with Customer, Including Assessed Tax														$ 886,000	$ 5,030,000	$ 1,475,000

Note 6 - Revenue 2 (Details Tex

Note 6 - Revenue 2 (Details Textual) - Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Start Date [Axis]: 2021-01-01	Dec. 31, 2020
Revenue, Remaining Performance Obligation, Percentage	100.00%
Revenue, Remaining Performance Obligation, Expected Timing of Satisfaction, Period (Month)	90 days

Note 7 - Liabilities Related _3

Note 7 - Liabilities Related to Sale of Future Royalties (Details Textual) - HCRP [Member] $ in Millions	1 Months Ended
	Apr. 30, 2016USD ($)
Proceeds from Sale of Future Royalties, Net	$ 20
Royalty Interest Due Each Year	$ 3
Royalty Interest, Percentage of Additional Royalties Due Each Year	15.00%
Royalty Interest, Additional Royalties Due Each Year	$ 1

Note 7 - Liabilities Related _4

Note 7 - Liabilities Related to Sale of Future Royalties - Deferred Revenue Activity (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Current portion	$ (2,779)	$ (2,916)
Long-term portion	12,150	$ 13,416
HealthCare Royalty Partners III, L.P. [Member] | Royalty Arrangement [Member]
Total liability related to sale of future royalties, start of year	16,332
Non-cash royalty revenue paid to HCRP	(3,277)
Non-cash interest expense recognized	1,874
Total liability related to sale of future royalties, end of year	14,929
Current portion	(2,779)
Long-term portion	$ 12,150

Note 8 - Leases (Details Textua

Note 8 - Leases (Details Textual) - USD ($)	3 Months Ended	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Lessee, Operating Lease, Number of Right-of-Use Leases		6
Lessee, Operating Lease, Number of Right-of-Use Leases, Subleased		1
Lessee, Operating Lease, Number Leases Exceeding One Year		3
Lessee, Operating Lease, Renewal Term (Year)		5 years
Operating Lease, Weighted Average Discount Rate, Percent		9.94%
Operating Lease, Weighted Average Remaining Lease Term (Year)		4 years 25 days
Lessee, Finance Lease, Number of Leases		0
Short-term Lease Commitment, Amount		$ 0
Operating Lease, Payments		$ 1,111,000	$ 983,000	$ 875,000
Operating Lease, Impairment Loss	$ 253,000

Note 8 - Leases - Lease Liabili

Note 8 - Leases - Lease Liabilities Payment Obligations (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019
2021	$ 2,633
2022	1,801
2023	1,585
2024	1,641
2025	1,112
Undiscounted total	8,772
Less: imputed interest	(1,564)
Present value of future minimum payments	7,208
Current portion of operating lease liability	(2,052)	$ (841)
Operating lease liability, net of current portion	$ 5,156	$ 1,472

Note 8 - Leases - Operating Lea

Note 8 - Leases - Operating Lease Expenses (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019
Operating lease cost	$ 1,145	$ 959
Short-term lease cost	13	15
Variable lease cost	264	162
Sublease income	(217)	(217)
Total lease cost	$ 1,205	$ 919

Note 8 - Leases - Liabilities R

Note 8 - Leases - Liabilities Related to Costs of Exit From Leased Premises (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Balance as of January 1, 2018		$ 233
Costs of exit from leased premises			359
Deferred rent on cease-use date			19
Impairment of property and equipment			(106)
Cash paid, net of receipts	$ (2,799)	$ (1,272)	(41)
Accretion charges, included in rent expense			2
Balance as of December 31, 2018			$ 233

Note 9 - Convertible Promisso_2

Note 9 - Convertible Promissory Notes, Related Parties (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Feb. 13, 2018	Dec. 10, 2014	Dec. 31, 2015	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Interest Expense, Total					$ 315	$ 821
Debt Conversion, Converted Instrument, Amount						35,577
Other Ownership Interests, Contributed Capital	$ 21,400
Convertible Promissory Notes Issued in 2014 and 2015 [Member]
Debt Instrument, Interest Rate, Stated Percentage			8.00%
Long-term Debt, Gross	35,600						$ 35,300
Debt Instrument, Principal Amount	29,400						29,400
Debt Instrument, Interest Amount	6,600						6,300
Debt Instrument, Unamortized Discount, Total	$ 400						$ 400
Interest Expense, Total						$ 300
Debt Conversion, Converted Instrument, Shares Issued (in shares)	1,571,702
Debt Instrument, Convertible, Conversion Price (in dollars per share)	$ 9.05
Debt Conversion, Converted Instrument, Amount	$ 14,200
Note Purchase Agreement [Member]
Proceeds from Convertible Debt		$ 18,400
Second Note Purchase Agreement [Member]
Proceeds from Convertible Debt			$ 11,000

Note 10 - Secured Promissory _2

Note 10 - Secured Promissory Note Payable to Oxford Finance (Details Textual) - USD ($)	Nov. 04, 2019	Dec. 22, 2016	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Feb. 13, 2018
Debt Conversion, Converted Instrument, Amount					$ 35,577,000
Amortization of Debt Issuance Costs	$ 98,000
Legal Fees	$ 2,000
Warrants in Connection with Loan Agreement [Member]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights (in shares)		7,563				10,914
Class of Warrant or Right, Exercise Price of Warrants or Rights (in dollars per share)		$ 33.11				$ 22.99
Warrants Not Settleable in Cash, Fair Value Disclosure		$ 134,000				$ 70,000
Loan Agreement [Member] | Oxford Finance [Member]
Long-term Debt, Gross		$ 5,000,000
Debt Instrument, Term (Year)		4 years
Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid		$ 325,000
Debt Conversion, Converted Instrument, Amount		$ 250,000
Debt Instrument, Interest Rate, Effective Percentage						10.50%
Interest Expense, Debt, Total				311,000	526,000
Interest Paid, Including Capitalized Interest, Operating and Investing Activities, Total				$ 223,000	$ 356,000
Loan Agreement [Member] | Oxford Finance [Member] | London Interbank Offered Rate (LIBOR) [Member]
Debt Instrument, Basis Spread on Variable Rate		6.17%

Note 11 - Commitments and Con_2

Note 11 - Commitments and Contingencies (Details Textual) $ in Millions	12 Months Ended
	Dec. 31, 2020USD ($)
Purchase Obligation, Total	$ 24.6
Long-term Purchase Commitment, Period (Month)	1 year 180 days

Note 12 - Stockholders' Equit_2

Note 12 - Stockholders' Equity (Details Textual)	Feb. 13, 2018USD ($)shares	Dec. 31, 2020USD ($)$ / sharesshares	Dec. 31, 2013USD ($)	Feb. 13, 2018USD ($)shares	Dec. 31, 2014USD ($)	Dec. 31, 2012USD ($)	Mar. 02, 2020USD ($)	Dec. 31, 2019$ / sharesshares	Sep. 30, 2019USD ($)	Apr. 11, 2019USD ($)	Mar. 20, 2019USD ($)
Preferred Stock, Shares Authorized (in shares) | shares		5,000,000						5,000,000
Preferred Stock, Par or Stated Value Per Share (in dollars per share) | $ / shares		$ 0.0001						$ 0.0001
Preferred Stock, Shares Outstanding, Ending Balance (in shares) | shares		0						0
Common Stock, Number of Votes Per Share		1
Dividends, Common Stock, Total		$ 0
Warrants in Connection with March 2019 Offering [Member]
Warrants and Rights Outstanding											$ 100,000
The March 2020 Offering Placement Agent Warrants [Member]
Warrants and Rights Outstanding							$ 453,000
Warrants in Connection With the April 2019 Offering [Member]
Warrants and Rights Outstanding										$ 333,000
Underwriter Warrants, September 2019 [Member]
Warrants and Rights Outstanding									$ 497,000
First Set of Warrants Expiring September 2024 [Member]
Warrant Exercise Price to be Entitled to Receive Cash Consideration, Fundamental Transaction (in dollars per share) | $ / shares		$ 0.30
Second Set of Warrants Expiring April 2024 [Member]
Warrant Exercise Price to be Entitled to Receive Cash Consideration, Fundamental Transaction (in dollars per share) | $ / shares		0.375
First Set of Warrants Expiring April 2024 [Member]
Warrant Exercise Price to be Entitled to Receive Cash Consideration, Fundamental Transaction (in dollars per share) | $ / shares		1.10
Warrants Expiring March 2025 [Member]
Warrant Exercise Price to be Entitled to Receive Cash Consideration, Fundamental Transaction (in dollars per share) | $ / shares		2.50
Warrants Expiring February 2025 [Member]
Warrant Exercise Price to be Entitled to Receive Cash Consideration, Fundamental Transaction (in dollars per share) | $ / shares		$ 3.125
Conversion From Series C Preferred Stock to Common Stock [Member]
Conversion of Stock, Shares Issued (in shares) | shares	696,028
Accumulated and Undeclared Dividends, Shares Issued Upon Conversion (in shares) | shares	253,851			253,851
Conversion From Series B Preferred Stock to Common Stock [Member]
Conversion of Stock, Shares Issued (in shares) | shares	599,259
Accumulated and Undeclared Dividends, Shares Issued Upon Conversion (in shares) | shares	265,340			265,340
Conversion From Series A Preferred Stock to Common Stock [Member]
Conversion of Stock, Shares Issued (in shares) | shares	104,065
Series C Convertible Preferred Stock [Member]
Proceeds from Issuance of Convertible Preferred Stock			$ 20,000,000
Preferred Stock, Dividend Rate, Percentage			8.00%
Dividends, Total				$ 0
Accumulated and Undeclared Dividends	$ 7,300,000			7,300,000
Pre-merger Accumulated and Undeclared Dividends	188,000			188,000
Series B Convertible Preferred Stock [Member]
Proceeds from Issuance of Convertible Preferred Stock					$ 16,000,000
Preferred Stock, Dividend Rate, Percentage					8.00%
Accumulated and Undeclared Dividends	7,600,000			7,600,000
Pre-merger Accumulated and Undeclared Dividends	$ 151,000			$ 151,000
Series A Convertible Preferred Stock [Member]
Proceeds from Issuance of Convertible Preferred Stock						$ 2,900,000
Dividends, Total						$ 0

Note 12 - Stockholders' Equit_3

Note 12 - Stockholders' Equity - Shares of Common Stock Reserved for Issuance (Details) - shares	Dec. 31, 2020	Dec. 31, 2019
Common stock reserved for issuance (in shares)	9,288,870	45,476,994
Options Issued and Outstanding [Member]
Common stock reserved for issuance (in shares)	6,813,033	1,811,652
Options Available for Future Grants [Member]
Common stock reserved for issuance (in shares)	1,230,863	295,180
Common Warrants [Member]
Common stock reserved for issuance (in shares)	1,244,974	43,370,162

Note 12 - Stockholders' Equit_4

Note 12 - Stockholders' Equity - Summary of Warrants Outstanding (Details)	Dec. 31, 2020$ / sharesshares
Warrants outstanding (in shares)	1,244,974
First Set of Warrants Expiring September 2024 [Member]
Warrants outstanding (in shares)	5,000
Exercise Price (in dollars per share) | $ / shares	$ 0.30
Second Set of Warrants Expiring September 2024 [Member]
Warrants outstanding (in shares)	224,797
Exercise Price (in dollars per share) | $ / shares	$ 0.375
First Set of Warrants Expiring April 2024 [Member]
Warrants outstanding (in shares)	225,966
Exercise Price (in dollars per share) | $ / shares	$ 1.10
Second Set of Warrants Expiring April 2024 [Member]
Warrants outstanding (in shares)	111,931
Exercise Price (in dollars per share) | $ / shares	$ 1.375
Warrants Expiring March 2025 [Member]
Warrants outstanding (in shares)	316,584
Exercise Price (in dollars per share) | $ / shares	$ 2.50
Warrants Expiring February 2025 [Member]
Warrants outstanding (in shares)	269,496
Exercise Price (in dollars per share) | $ / shares	$ 3.125
Warrants Expiring March 2024 [Member]
Warrants outstanding (in shares)	80,286
Exercise Price (in dollars per share) | $ / shares	$ 3.125
Warrants Expiring December 2026 [Member]
Warrants outstanding (in shares)	10,914
Exercise Price (in dollars per share) | $ / shares	$ 22.99

Note 12 - Stockholders' Equit_5

Note 12 - Stockholders' Equity - Assumptions for Fair Value of Warrants (Details)	Mar. 02, 2020USD ($)shares	Sep. 30, 2019USD ($)shares	Apr. 11, 2019USD ($)shares	Mar. 20, 2019USD ($)shares
Warrants in Connection with March 2019 Offering [Member]
Aggregate valuation on issuance date | $				$ 100,000
Number of warrants issued (in shares) | shares				84,000
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Exercise Price [Member]
Measurement Input				3.125
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Share Price [Member]
Measurement Input				2.08
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Risk Free Interest Rate [Member]
Measurement Input				0.0234
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Expected Term [Member]
Measurement Input				5
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Price Volatility [Member]
Measurement Input				0.8
Warrants in Connection with March 2019 Offering [Member] | Measurement Input, Expected Dividend Rate [Member]
Measurement Input
Warrants in Connection With the April 2019 Offering [Member]
Aggregate valuation on issuance date | $			$ 333,000
Number of warrants issued (in shares) | shares			636,364
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Exercise Price [Member]
Measurement Input			1.375
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Share Price [Member]
Measurement Input			0.89
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Risk Free Interest Rate [Member]
Measurement Input			0.0231
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Expected Term [Member]
Measurement Input			5
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Price Volatility [Member]
Measurement Input			0.83
Warrants in Connection With the April 2019 Offering [Member] | Measurement Input, Expected Dividend Rate [Member]
Measurement Input
Warrants in Connection with the September 2019 Offering [Member]
Aggregate valuation on issuance date | $		$ 497,000
Number of warrants issued (in shares) | shares		2,115,738
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Exercise Price [Member]
Measurement Input		0.375
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Share Price [Member]
Measurement Input		0.36
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Risk Free Interest Rate [Member]
Measurement Input		0.0155
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Expected Term [Member]
Measurement Input		5
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Price Volatility [Member]
Measurement Input		0.83
Warrants in Connection with the September 2019 Offering [Member] | Measurement Input, Expected Dividend Rate [Member]
Measurement Input
Warrants in Connection with March 2020 Offering [Member]
Aggregate valuation on issuance date | $	$ 453,000
Number of warrants issued (in shares) | shares	280,000
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Exercise Price [Member]
Measurement Input	3.125
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Share Price [Member]
Measurement Input	2.34
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Risk Free Interest Rate [Member]
Measurement Input	0.0088
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Expected Term [Member]
Measurement Input	4.99
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Price Volatility [Member]
Measurement Input	0.98
Warrants in Connection with March 2020 Offering [Member] | Measurement Input, Expected Dividend Rate [Member]
Measurement Input

Note 13 - Equity Incentive Pl_3

Note 13 - Equity Incentive Plans (Details Textual) - USD ($)	Jul. 24, 2020	Jul. 20, 2020	Jul. 09, 2020	Jun. 15, 2020	Mar. 24, 2020	Apr. 23, 2019	Mar. 31, 2020	Nov. 30, 2016	Sep. 30, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Jun. 23, 2020	Dec. 31, 2017	Jul. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)										1,230,863	295,180	200,650
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Number, Ending Balance (in shares)										6,813,033	1,811,652	865,163		304,850
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)										$ 2.70	$ 2.74	$ 8.13		$ 9.50
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term (Year)										8 years 361 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Intrinsic Value										$ 22,500,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Number (in shares)										6,502,213
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Exercise Price (in dollars per share)										$ 2.68
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Weighted Average Remaining Contractual Term (Year)										8 years 354 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Vested and Expected to Vest, Outstanding, Aggregate Intrinsic Value										$ 21,600,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number (in shares)										2,886,541
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Exercise Price (in dollars per share)										$ 2.65
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term (Year)										8 years 237 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value										$ 9,900,000
Share Price (in dollars per share)							$ 1.70			$ 5.71
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period, Intrinsic Value										$ 2,200,000		$ 0
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period (in shares)										414,676	0	2,013
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)					2,610,000					5,579,800	1,791,030	431,100
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share)					$ 1.70					$ 2.66	$ 0.67	$ 5.17
Performance-based Restricted Stock Units (PRSUs) [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted (in shares)							411,000
Share-based Payment Arrangement, Expense									$ 632,000
Share-based Payment Arrangement, Reversal of Expense										$ 632,000
Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Forfeitures and Expirations, Total (in shares)										411,000
March Option Awards [Member] | Share-based Payment Arrangement, Tranche One [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage					25.00%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Month)					2 years
Performance-based Options [Member] | Chief Executive Officer [Member]
Share Price (in dollars per share)				$ 2.46
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)				900,000
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Volatility Rate				105.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Risk Free Interest Rate				0.35%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Dividend Rate				0.00%
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions, Expected Term (Year)				5 years 83 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)				$ 0.31
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Grant Date Fair Value				$ 279,000
Performance-based Options [Member] | Share-based Payment Arrangement, Tranche One [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage				33.33%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Minimum Closing Price for Ten Consecutive Trading Days (in dollars per share)			$ 5	$ 5
Performance-based Options [Member] | Share-based Payment Arrangement, Tranche Two [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage				33.33%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Minimum Closing Price for Ten Consecutive Trading Days (in dollars per share)		$ 7.50		$ 7.50
Performance-based Options [Member] | Share-based Payment Arrangement, Tranche Three [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage				33.33%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Minimum Closing Price for Ten Consecutive Trading Days (in dollars per share)	$ 10			$ 10
Time-based Options [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross (in shares)				845,280
Time-based Options [Member] | Share-based Payment Arrangement, Tranche One [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage				25.00%
Time-based Options [Member] | Share-based Payment Arrangement, Tranche Two [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Percentage				75.00%
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period (Month)				3 years
Time-based Options [Member] | Share-based Payment Arrangement, Tranche Three [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Rights, Accelerated Vesting Percentage				50.00%
Performance-based Options and Time-based Options [Member] | Chief Executive Officer [Member]
Share-based Compensation Arrangements by Share-based Payment Award, Options, Grants in Period, Weighted Average Exercise Price (in dollars per share)				$ 2.46
Share-based Payment Arrangement, Option [Member]
Share-based Payment Arrangement, Expense										$ 4,358,000	$ 627,000	$ 539,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value (in dollars per share)										$ 2.49	$ 0.48	$ 3.59
Share-based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount										$ 8,200,000
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition (Year)										2 years 113 days
The 2007 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)															0
The 2016 Equity Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in shares)						0
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)								10 years
The 2019 Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period (Year)						10 years
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in shares)						1,600,000							8,000,000

Note 13 - Equity Incentive Pl_4

Note 13 - Equity Incentive Plans - Summary of Stock Option Transactions (Details) - $ / shares	Mar. 24, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Shares available for grant, balance (in shares)		295,180	200,650
Number of options outstanding, beginning balance (in shares)		1,811,652	865,163	304,850
Weighted average exercise price, balance (in dollars per share)		$ 2.74	$ 8.13	$ 9.50
Shares available for grant, assumed on consummation of Merger (in shares)				291,102
Number of options outstanding, assumed on consummation of Merger (in shares)				627,106
Weighted average exercise price, assumed on consummation of Merger (in dollars per share)				$ 26.33
Shares available for grant, granted (in shares)		(5,579,800)	(1,791,030)	(431,100)
Number of options outstanding, granted (in shares)	2,610,000	5,579,800	1,791,030	431,100
Weighted average exercise price, granted (in dollars per share)	$ 1.70	$ 2.66	$ 0.67	$ 5.17
Number of options outstanding, exercised (in shares)		(414,676)	0	(2,013)
Weighted average exercise price, exercised (in dollars per share)		$ 1.45		$ 6.49
Shares available for grant, forfeited (in shares)		105,910	483,849	71,500
Number of options outstanding, forfeited (in shares)		(105,992)	(592,528)	(89,903)
Weighted average exercise price, forfeited (in dollars per share)		$ 1.65	$ 1.57	$ 5.90
Shares available for grant, canceled (in shares)		9,573	25,100	269,148
Number of options outstanding, canceled (in shares)		(57,751)	(252,013)	(405,977)
Weighted average exercise price, canceled (in dollars per share)		$ 10.57	$ 9.25	$ 34.64
Shares availabe for grant, 2019 Plan Amendment (in shares)		6,400,000	1,600,000
Shares available for grant, removed from 2016 Plan (in shares)			(223,389)
Shares available for grant, balance (in shares)		1,230,863	295,180	200,650
Number of options outstanding, balance (in shares)		6,813,033	1,811,652	865,163
Weighted average exercise price, balance (in dollars per share)		$ 2.70	$ 2.74	$ 8.13

Note 13 - Equity Incentive Pl_5

Note 13 - Equity Incentive Plans - Assumptions of Options (Details) - Share-based Payment Arrangement, Option [Member]	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Minimum [Member]
Risk-free interest rate	0.40%	1.68%	2.79%
Expected term (in years) (Year)	5 years 80 days	5 years 142 days	5 years 306 days
Expected volatility	94.00%	83.00%	78.00%
Maximum [Member]
Risk-free interest rate	0.88%	2.31%	2.80%
Expected term (in years) (Year)	10 years	10 years	6 years 18 days
Expected volatility	111.00%	85.00%	80.00%

Note 13 - Equity Incentive Pl_6

Note 13 - Equity Incentive Plans - Total Stock-based Compensation Recognized for Options (Details) - Share-based Payment Arrangement, Option [Member] - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Share-based Payment Arrangement, Expense	$ 4,358	$ 627	$ 539
Research and Development Expense [Member]
Share-based Payment Arrangement, Expense	1,563	253	254
General and Administrative Expense [Member]
Share-based Payment Arrangement, Expense	$ 2,795	$ 374	$ 285

Note 14 - Related Party Trans_2

Note 14 - Related Party Transactions (Details Textual)	1 Months Ended
	Apr. 30, 2020USD ($)
Disgorgement of Stockholder Short-swing Profits [Member]
Related Party Transaction, Amounts of Transaction	$ 652,000

Note 15 - Restructuring Charg_3

Note 15 - Restructuring Charges and (Reversals) (Details Textual) - USD ($)	1 Months Ended	12 Months Ended
	Sep. 30, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Payments for Restructuring		$ 2,799,000	$ 1,272,000	$ 41,000
Contract Termination [Member]
Payments for Restructuring	$ 2,252,000	$ 2,252,000

Note 15 - Restructuring Charg_4

Note 15 - Restructuring Charges and (Reversals) - Restructuring Liabilities (Details) - USD ($)	1 Months Ended	12 Months Ended
	Sep. 30, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Cumulative cost incurred		$ 4,071,000
Balance		3,648,000
Period charges		122,000	4,920,000
Cash paid, net of receipts		(2,799,000)	(1,272,000)	$ (41,000)
Period reversals		(971,000)
Balance			3,648,000
Contract Termination [Member]
Cumulative cost incurred		2,252,000
Balance		3,223,000
Period charges			3,223,000
Cash paid, net of receipts	$ (2,252,000)	(2,252,000)
Period reversals		(971,000)
Balance			3,223,000
Employee Severance [Member]
Cumulative cost incurred		368,000
Balance		368,000
Period charges			368,000
Cash paid, net of receipts		(368,000)
Period reversals
Balance			368,000
Impairment Charges [Member]
Cumulative cost incurred		1,272,000
Balance
Period charges			1,272,000
Cash paid, net of receipts			(1,272,000)
Period reversals
Balance
Other Restructuring [Member]
Cumulative cost incurred		179,000
Balance		57,000
Period charges		122,000	57,000
Cash paid, net of receipts		(179,000)
Period reversals
Balance			$ 57,000

Note 16 - Benefit Plan (Details

Note 16 - Benefit Plan (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay	3.00%
Defined Contribution Plan, Cost	$ 96,000	$ 140,000	$ 124,000
Defined Contribution Plan, Administrative Expense	$ 10,000	$ 14,000	$ 9,000

Note 17 - Income Taxes (Details

Note 17 - Income Taxes (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018	Dec. 31, 2017
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	21.00%	21.00%	21.00%
Operating Loss Carryforwards, Annual Limitations	$ 3,200,000	$ 62,000
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount	8,600,000	(35,300,000)	$ 25,700,000
Unrecognized Tax Benefits, Ending Balance	1,281,000	851,000	1,582,000	$ 1,404,000
Unrecognized Tax Benefits, Income Tax Penalties and Interest Expense, Total	0	0	0
Domestic Tax Authority [Member]
Operating Loss Carryforwards, Total	51,600,000	18,000,000	92,300,000
Domestic Tax Authority [Member] | Research Tax Credit Carryforward [Member]
Tax Credit Carryforward, Amount	$ 900,000	100,000	3,000,000
Domestic Tax Authority [Member] | Internal Revenue Service (IRS) [Member]
Open Tax Year	2017 2048 2019 2020
State and Local Jurisdiction [Member]
Operating Loss Carryforwards, Total	$ 26,800,000	1,600,000	76,900,000
Open Tax Year	2016 2017 2018 2019 2020
State and Local Jurisdiction [Member] | Research Tax Credit Carryforward [Member]
Tax Credit Carryforward, Amount	$ 3,400,000	$ 2,700,000	$ 2,300,000
Foreign Tax Authority [Member]
Open Tax Year	2015 2016 2017 2018 2019 2020
Foreign Tax Authority [Member] | Australian Taxation Office [Member]
Operating Loss Carryforwards, Total	$ 6,800,000

Note 17 - Income Taxes - Compon

Note 17 - Income Taxes - Components of Income Tax Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Current:
Federal
State	3	2	3
Foreign	235	488	106
Total Current	238	490	109
Deferred:
Federal
State
Foreign
Total Deferred
Provision for income taxes	$ 238	$ 490	$ 109

Note 17 - Income Taxes - Comp_2

Note 17 - Income Taxes - Components of Deferred Tax Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Net operating loss carry-forwards	$ 14,161	$ 6,924	$ 43,822
Research and development tax credits	2,497	1,591	3,357
Capitalized research and development	4,534	4,773	2,326
Sale of future royalties	7,178	7,486	8,383
Lease Liability	1,695	492
Accruals, reserves and other	1,327	1,253	714
Total deferred tax assets	31,392	22,519	58,602
Valuation allowance	(21,952)	(13,365)	(48,626)
Deferred tax assets net of valuation allowance	9,440	9,154	9,976
Intangible assets	(7,832)	(8,730)	(9,976)
Right-of-use assets	(1,608)	(424)
Total deferred tax liabilities	(9,440)	(9,154)	(9,976)
Net deferred tax assets

Note 17 - Income Taxes - Reconc

Note 17 - Income Taxes - Reconciliation of Effective Tax Rate (Details)	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
U.S. federal taxes at statutory rate	21.00%	21.00%	21.00%
State taxes (net of federal benefit)	2.90%	0.40%	0.60%
Foreign rate differential	(0.70%)	(2.60%)	3.10%
Global intangible low-taxed income			(8.80%)
Permanently non-deductible items	2.20%	(3.70%)	(2.50%)
Tax credits	2.80%	1.70%	2.10%
Change in valuation allowance	(26.80%)	194.20%	(20.40%)
Tax attributes write-off due to change in control	0.50%	(208.30%)
Prior year true-up	(2.50%)	(0.90%)
NOL and credit adjustments			(3.80%)
Bargain purchase gain			8.10%
Other	(0.10%)	(4.50%)
Provision for income taxes	(0.70%)	(2.70%)	(0.60%)

Note 17 - Income Taxes - Unreco

Note 17 - Income Taxes - Unrecognized Tax Benefits (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Beginning Balance	$ 851	$ 1,582	$ 1,404
Additions based on tax positions related to the current year	431	159	181
Decreases related to prior years’ tax positions	(1)	(890)	(3)
Ending Balance	$ 1,281	$ 851	$ 1,582

Note 18 - Net Loss Per Share _3

Note 18 - Net Loss Per Share Attributable to Common Stockholders (Details Textual) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Dilutive Securities, Effect on Basic Earnings Per Share, Total	$ 0	$ 0	$ 0

Note 18 - Net Loss Per Share _4

Note 18 - Net Loss Per Share Attributable to Common Stockholders - Calculation of Basic and Diluted Net (Loss) Income Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended												12 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Net loss	$ (13,861)	$ (8,085)	$ (8,977)	$ (1,297)	$ (6,409)	$ (5,260)	$ (5,637)	$ (1,339)	$ (4,902)	$ (6,548)	$ (8,871)	$ 2,314	$ (32,220)	$ (18,645)	$ (18,007)
Series B and C preferred dividend															(339)
Net loss attributable to common stockholders									$ (4,902)	$ (6,548)	$ (8,871)	$ 1,975	$ (32,220)	$ (18,645)	$ (18,346)
Shares used to compute net loss per share – basic and diluted (in shares)													88,295,762	21,569,523	6,316,065
Net loss per share – basic and diluted (in dollars per share)	$ (0.13)	$ (0.08)	$ (0.12)	$ (0.02)	$ (0.13)	$ (0.32)	$ (0.39)	$ (0.18)					$ (0.36)	$ (0.86)	$ (2.90)

Note 18 - Net Loss Per Share _5

Note 18 - Net Loss Per Share Attributable to Common Stockholders - Summary of Antidilutive Securities (Details) - shares	12 Months Ended
	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)	19,183,231	19,163,520	1,261,124
Share-based Payment Arrangement, Option [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)	4,409,806	1,583,575	839,396
Warrant [Member] | Common Stock [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)	14,773,425	17,579,945	9,658
Warrant [Member] | Preferred Stock [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)			891
Series B and C Convertible Preferred Stock, Including Cumulative Dividends [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)			213,760
Series A Convertible Preferred Stock [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)			12,260
Convertible Debt Securities [Member]
Potentially dilutive securities excluded from denominator of the diluted earnings per share computation (in shares)			185,159

Note 19 - Quarterly Financial_3

Note 19 - Quarterly Financial Data (Unaudited) - Quarterly Financial Information (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended												12 Months Ended
	Dec. 31, 2020	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Dec. 31, 2019	Sep. 30, 2019	Jun. 30, 2019	Mar. 31, 2019	Dec. 31, 2018	Sep. 30, 2018	Jun. 30, 2018	Mar. 31, 2018	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Revenue	$ 356	$ 265	$ 523	$ 2,902	$ 3,916	$ 454	$ 85	$ 5,407	$ 1,767	$ 281	$ 608	$ 1,503	$ 4,046	$ 9,862	$ 4,159
Operating expenses	13,717	7,854	9,049	3,596	9,542	5,168	5,082	5,855	5,953	6,161	8,383	5,418	34,216	25,647	25,915
Net loss	$ (13,861)	$ (8,085)	$ (8,977)	$ (1,297)	$ (6,409)	$ (5,260)	$ (5,637)	$ (1,339)	(4,902)	(6,548)	(8,871)	2,314	$ (32,220)	$ (18,645)	$ (18,007)
Net loss per share – basic and diluted (in dollars per share)	$ (0.13)	$ (0.08)	$ (0.12)	$ (0.02)	$ (0.13)	$ (0.32)	$ (0.39)	$ (0.18)					$ (0.36)	$ (0.86)	$ (2.90)
Net income (loss) attributable to common stockholders									$ (4,902)	$ (6,548)	$ (8,871)	$ 1,975	$ (32,220)	$ (18,645)	$ (18,346)
Net income (loss) per share – basic (in dollars per share)									$ (0.69)	$ (0.92)	$ (1.24)	$ 0.54
Net income (loss) per share – diluted (in dollars per share)									$ (0.69)	$ (0.92)	$ (1.24)	$ 0.49

Note 20 - Subsequent Events (De

Note 20 - Subsequent Events (Details Textual) - USD ($)	Mar. 20, 2019	Feb. 25, 2021	Dec. 31, 2020	Dec. 31, 2020	Dec. 31, 2019	Dec. 31, 2018
Stock Issued During Period, Shares, New Issues (in shares)	1,200,000
Proceeds from Issuance of Common Stock	$ 2,500,000
Proceeds from Warrant Exercises				$ 25,951,000	$ 180,000
Subsequent Event [Member] | Warrants Issued in Connection with Open Market Sale Agreement [Member]
Class of Warrant or Right, Exercised During Period (in shares)		830,722
Proceeds from Warrant Exercises		$ 1,600,000
Open Market Sale Agreement [Member]
Stock Issued During Period, Shares, New Issues (in shares)			692,651
Proceeds from Issuance of Common Stock			$ 4,900,000
Open Market Sale Agreement [Member] | Subsequent Event [Member]
Stock Issued During Period, Shares, New Issues (in shares)		6,654,367
Proceeds from Issuance of Common Stock		$ 65,800,000