Osi Pharmaceuticals (OSIP) 8-K Departure of Directors or Principal Officers

EXHIBIT 10.1

[PROSIDION LIMITED LETTERHEAD]

Dr Daryl Granner
Vanderbilt University Medical Centre
707 Light Hall
Nashville
Tennessee 37232
USA

10 January 2007

Dear Sirs

Scientific Advisory Board and Consulting Agreement, dated as of 10^th February 2006 between Prosidion Limited and Dr Daryl Granner (the “Agreement”)

This letter will serve as notice of our desire to renew the term of the Agreement for an additional twelve-month period, through to 31^st December 2007. All other terms and conditions of the Agreement will remain in full force and effect.

Please indicate your agreement to the foregoing by having both copies of this letter signed by an authorized representative of your company and returning one original, fully signed copy for the attention of Sian Bishop, General Counsel to the address listed above.

SIGNED for and on behalf of:
PROSIDION LIMITED

By:	/s/ Anker Lundemose
		(Signature)
Anker Lundemose
		(Name Printed)
January 25, 2007
		(Date)
ACCEPTED AND AGREED:
DR DARYL GRANNER
By:	/s/ Daryl K. Granner
		(Signature)
Daryl K. Granner
		(Name Printed)
January 25, 2007
		(Date)