Exhibit 12.1
CELLDEX PHARMACEUTICALS, INC.
COMPUTATION OF RATIO OF EARNINGS TO COMBINED FIXED CHARGES
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| Year Ended December 31, |
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| 2011 |
| 2010 |
| 2009 |
| 2008 |
| 2007 |
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Loss from continuing operations before taxes |
| $ | (43,399 | ) | $ | (6,455 | ) | $ | (36,850 | ) | $ | (48,756 | ) | $ | (15,508 | ) |
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Fixed Charges: |
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Interest expensed and amortization of debt discount |
| 1,796 |
| 1,337 |
| 452 |
| 156 |
| — |
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Estimate of interest within rental expense (2) |
| 841 |
| 821 |
| 825 |
| 726 |
| 99 |
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Total fixed charges |
| 2,637 |
| 2,158 |
| 1,277 |
| 882 |
| 99 |
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Loss as defined for ratio to fixed charges |
| $ | (40,762 | ) | $ | (4,297 | ) | $ | (35,573 | ) | $ | (47,874 | ) | $ | (15,409 | ) |
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Ratio of earnings to fixed charges |
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| (1) |
| (1) |
| (1) |
| (1) |
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(1) Due to the Company’s loss from continuing operations for the years ended December 31, 2011, 2010, 2009, 2008, and 2007 earnings were insufficient to cover fixed charges by $43.4 million, $6.5 million, $36.9 million, $48.8 million, and $15.5 million, respectively.
(2) Interest component on rentals estimated to be one-third of rentals
