Segment, Geographic and Other Revenue Information | Segment, Geographic and Other Revenue Information A. Segment Information We manage our commercial operations through two distinct business segments: Pfizer Innovative Health (IH) and Pfizer Essential Health (EH), which was previously known as Established Products. Beginning in the second quarter of 2016, we reorganized our operating segments to reflect that we now manage our innovative pharmaceutical and consumer healthcare operations as one business segment, IH. From the beginning of our fiscal year 2014 until the second quarter of 2016, these operations were managed as two business segments: the GIP segment and the VOC segment. We have revised prior-period information (Revenues and Earnings, as defined by management) to reflect the reorganization. The IH and EH operating segments are each led by a single manager. Each operating segment has responsibility for its commercial activities and for certain IPR&D projects for new investigational products and additional indications for in-line products that generally have achieved proof-of-concept. Each business has a geographic footprint across developed and emerging markets. We regularly review our segments and the approach used by management to evaluate performance and allocate resources. Operating Segments Some additional information about our business segments follows: IH Segment EH Segment IH focuses on developing and commercializing novel, value-creating medicines and vaccines that significantly improve patients’ lives, as well as products for consumer healthcare. Key therapeutic areas include internal medicine, vaccines, oncology, inflammation & immunology, rare diseases and consumer healthcare. EH includes legacy brands that have lost or will soon lose market exclusivity in both developed and emerging markets, branded generics, generic sterile injectable products, biosimilars and, through February 2, 2017, infusion systems. EH also includes an R&D organization, as well as our contract manufacturing business. Leading brands include: - Prevnar 13 - Xeljanz - Eliquis - Lyrica (U.S., Japan and certain other markets) - Enbrel (outside the U.S. and Canada) - Viagra (U.S. and Canada) - Ibrance - Xtandi - Several OTC consumer products (e.g., Advil and Centrum ) Leading brands include: - Lipitor - Premarin family - Norvasc - Lyrica (Europe, Russia, Turkey, Israel and Central Asia countries) - Celebrex - Pristiq - Several sterile injectable products The following change in 2016 impacted IH: • In connection with the formation in early 2016 of the GPD organization, a new unified center for late-stage development for our innovative products, which is generally responsible for the clinical development of assets that are in clinical trials for our WRD and Innovative portfolios, effective in the second quarter of 2016, certain development-related functions transferred from IH to GPD. The following changes in 2016 impacted EH: • Beginning in 2016, our contract manufacturing business, Pfizer CentreOne, is part of EH. Pfizer CentreOne consists of (i) the revenues and expenses of legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation (previously known as Pfizer CentreSource or PCS), including the revenues and expenses related to our manufacturing and supply agreements with Zoetis, which prior to 2016 was managed outside EH as part of PGS and previously reported in “Other Unallocated” costs; and (ii) the revenues and expenses of legacy Hospira's One-2-One sterile injectables contract manufacturing operation, which has been included in EH since we acquired Hospira on September 3, 2015. • In connection with the formation of a new EH R&D organization effective in the first quarter of 2016, certain functions transferred from Pfizer’s WRD organization to the new EH R&D organization. The new R&D organization within EH expects to develop potential new sterile injectable drugs and therapeutic solutions, as well as biosimilars. Our chief operating decision maker uses the revenues and earnings of the two operating segments, among other factors, for performance evaluation and resource allocation. Other Costs and Business Activities Certain costs are not allocated to our operating segment results, such as costs associated with the following: • WRD, which is generally responsible for research projects for our IH business until proof-of-concept is achieved and then for transitioning those projects to the IH segment via the newly formed GPD organization for possible clinical and commercial development. R&D spending may include upfront and milestone payments for intellectual property rights. The WRD organization also has responsibility for certain science-based and other platform-services organizations, which provide technical expertise and other services to the various R&D projects, including EH R&D projects. WRD is also responsible for facilitating all regulatory submissions and interactions with regulatory agencies, including all safety-event activities. • GPD, which is generally responsible for the clinical development of assets that are in clinical trials for our WRD and Innovative portfolios. GPD also provides technical support and other services to Pfizer R&D projects. In connection with the formation of the GPD organization, effective in the second quarter of 2016, certain development-related functions transferred from WRD and IH to GPD. We have reclassified approximately $78 million of costs in the first quarter of 2016, $341 million of costs in 2015, and $343 million of costs in 2014 from WRD to GPD as well as $76 million of costs in the first quarter of 2016, $318 million of costs in 2015 and $271 million of costs in 2014 from IH to GPD to conform to the presentation as part of GPD in 2016. • Pfizer Medical, which is responsible for the provision of medical information to healthcare providers, patients and other parties, transparency and disclosure activities, clinical trial results publication, grants for healthcare quality improvement and medical education, and partnerships with global public health and medical associations. In 2015 and 2014, Medical was also responsible for regulatory inspection readiness reviews, internal audits of Pfizer-sponsored clinical trials and internal regulatory compliance processes, which are now part of the compliance function within Corporate. • Corporate, representing platform functions (such as worldwide technology, global real estate operations, legal, finance, human resources, worldwide public affairs, compliance and worldwide procurement) and certain compensation and other corporate costs, such as interest income and expense, and gains and losses on investments. • Other unallocated costs, representing overhead expenses associated with our manufacturing and commercial operations that are not directly assessed to an operating segment as business unit (segment) management does not manage these costs (which include manufacturing variances associated with production). The increase in Cost of sales in 2016 reflects, among other items, the change in manufacturing variances driven by demand decreases versus plan for certain legacy Hospira and legacy Pfizer products. • Certain transactions and events such as (i) purchase accounting adjustments, where we incur expenses associated with the amortization of fair value adjustments to inventory, intangible assets and PP&E; (ii) acquisition-related costs, where we incur costs for executing the transaction, integrating the acquired operations and restructuring the combined company; and (iii) certain significant items, which are substantive and/or unusual, and in some cases recurring, items that are evaluated on an individual basis by management and which include non-acquisition-related restructuring costs, as well as costs incurred for legal settlements, asset impairments and disposals of assets or businesses, including, as applicable, any associated transition activities. Segment Assets We manage our assets on a total company basis, not by operating segment, as many of our operating assets are shared (such as our plant network assets) or commingled (such as accounts receivable, as many of our customers are served by multiple operating segments). Therefore, our chief operating decision maker does not regularly review any asset information by operating segment and, accordingly, we do not report asset information by operating segment. Total assets were approximately $172 billion as of December 31, 2016 and approximately $167 billion as of December 31, 2015 . Selected Income Statement Information The following table provides selected income statement information by reportable segment: Revenues Earnings (a) Depreciation and Amortization (b) Year Ended December 31, Year Ended December 31, Year Ended December 31, (MILLIONS OF DOLLARS) 2016 2015 2014 2016 2015 2014 2016 2015 2014 Reportable Segments: IH (c) $ 29,197 $ 26,758 $ 24,005 $ 15,854 $ 14,581 $ 12,743 $ 583 $ 552 $ 522 EH (d) 23,627 22,094 25,401 12,898 12,714 16,020 600 446 490 Total reportable segments 52,824 48,851 49,406 28,752 27,295 28,763 1,183 998 1,012 Other business activities (e) — — — (3,184 ) (3,091 ) (3,151 ) 86 77 74 Reconciling Items: Corporate (f) — — — (5,326 ) (5,430 ) (5,200 ) 356 354 384 Purchase accounting adjustments (f) — — — (4,185 ) (3,953 ) (3,641 ) 3,890 3,573 3,782 Acquisition-related costs (f) — — — (785 ) (894 ) (183 ) 7 75 53 Certain significant items (g) — — 198 (5,888 ) (4,321 ) (3,749 ) 200 48 207 Other unallocated (f) — — — (1,032 ) (642 ) (601 ) 35 33 24 $ 52,824 $ 48,851 $ 49,605 $ 8,351 $ 8,965 $ 12,240 $ 5,757 $ 5,157 $ 5,537 (a) Income from continuing operations before provision for taxes on income. (b) Certain production facilities are shared. Depreciation is allocated based on estimates of physical production. Amounts here relate solely to the depreciation and amortization associated with continuing operations. (c) On June 24, 2016, we acquired Anacor and on September 28, 2016, we acquired Medivation. Commencing from their respective acquisition dates, our results of operations and IH’s operating results for 2016 include approximately six months of legacy Anacor operations, which were immaterial, and approximately three months of legacy Medivation operations. Additionally, in connection with the formation in early 2016 of the GPD organization, effective in the second quarter of 2016, certain development-related functions transferred from IH to GPD. We have reclassified approximately $76 million of costs in the first quarter of 2016, $318 million of costs in 2015 and $271 million of costs in 2014 from IH to GPD to conform to the presentation as part of GPD in 2016. (d) On September 3, 2015, we acquired Hospira. Commencing from the acquisition date, our results of operations and EH’s operating results include legacy Hospira commercial operations, including the legacy Hospira One-2-One contract manufacturing business. In accordance with our domestic and international reporting periods, our results of operations and EH's operating results for 2015 reflect four months of legacy Hospira U.S. operations and three months of legacy Hospira International operations. See Note 2A for additional information. Beginning in 2016, our contract manufacturing business, Pfizer CentreOne, is part of EH. Pfizer CentreOne consists of (i) the revenues and expenses of legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation (previously known as Pfizer CentreSource or PCS), including the revenues and expenses related to our manufacturing and supply agreements with Zoetis, which prior to 2016 was managed outside EH as part of PGS and previously reported in “Other Unallocated” costs; and (ii) the revenues and expenses of legacy Hospira's One-2-One sterile injectables contract manufacturing operation, which has been included in EH since we acquired Hospira on September 3, 2015. We have reclassified prior period PCS operating results ( $506 million of PCS revenues and $96 million of PCS earnings in 2015, which in 2015 includes revenues and expenses related to our manufacturing and supply agreements with Zoetis, and $253 million of PCS revenues and $69 million of PCS earnings in 2014) to conform to the current period presentation as part of EH. As noted above, in connection with the formation in 2016 of a new EH R&D organization, certain functions transferred from Pfizer’s WRD organization to the new EH R&D organization. We have reclassified approximately $274 million of costs in 2015 and $281 million of costs in 2014 from WRD to EH to conform to the current period presentation as part of EH. (e) Other business activities includes the costs managed by our WRD, GPD and Pfizer Medical organizations. (f) For a description, see the “Other Costs and Business Activities” section above. (g) Certain significant items are substantive and/or unusual, and in some cases recurring, items (such as restructuring or legal charges) that, either as a result of their nature or size, would not be expected to occur as part of our normal business on a regular basis. For Revenues in 2014, certain significant items primarily represent revenues related to our manufacturing and supply agreements with Zoetis. For Earnings in 2016 , certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $1.5 billion , (ii) charges for certain legal matters of $494 million , (iii) an impairment charge related to the write-down of the HIS net assets to fair value less estimated costs to sell of $1.7 billion , (iv) certain asset impairment charges of $1.4 billion , (v) charges for business and legal entity alignment of $261 million and (vi) other charges of $509 million . For additional information, see Note 2B, Note 3 and Note 4 . For Earnings in 2015, certain significant items includes: (i) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $584 million , (ii) foreign currency loss and inventory impairment related to Venezuela of $878 million , (iii) certain asset impairment charges of $787 million , (iv) a charge related to pension settlements of $491 million , (v) charges for business and legal entity alignment of $282 million , (vi) charges for certain legal matters of $968 million and (vii) other charges of $332 million . For additional information, see Note 3 and Note 4. For Earnings in 2014, certain significant items includes: (i) charges for certain legal matters of $999 million , (ii) certain asset impairments of $440 million , (iii) a charge for an additional year of Branded Prescription Drug Fee of $215 million , (iv) restructuring charges and implementation costs associated with our cost-reduction initiatives that are not associated with an acquisition of $598 million , (v) an upfront fee associated with collaborative arrangement with Merck KGaA of $1.2 billion , (vi) charges for business and legal entity alignment of $168 million and (vii) other charges of $165 million . For additional information, see Note 2D, Note 3 and Note 4 . Equity in the net income of investees accounted for by the equity method is not significant for any of our operating segments. The operating segment information does not purport to represent the revenues, costs and income from continuing operations before provision for taxes on income that each of our operating segments would have recorded had each segment operated as a standalone company during the periods presented. B. Geographic Information Revenues exceeded $500 million in each of 11 countries outside the U.S. in 2016 and in each of 12 countries outside the U.S. in 2015 and 2014 , respectively. The U.S. is the only country to contribute more than 10% of total revenue in 2016 , 2015 and 2014. The following table provides revenues by geographic area: Year Ended December 31, (MILLIONS OF DOLLARS) 2016 2015 2014 United States (a) $ 26,369 $ 21,704 $ 19,073 Developed Europe (a), (b) 9,306 9,714 11,719 Developed Rest of World (a), (c) 6,729 6,298 7,314 Emerging Markets (a), (d) 10,420 11,136 11,499 Revenues $ 52,824 $ 48,851 $ 49,605 (a) On June 24, 2016, we acquired Anacor and on September 28, 2016, we acquired Medivation. Commencing from their respective acquisition dates, our results of operations include the operating results of Anacor and Medivation. In accordance with our domestic reporting period, our results of operations for 2016 include approximately six months of legacy Anacor operations, which were immaterial, and approximately three months of legacy Medivation operations. On September 3, 2015, we acquired Hospira. Commencing from the acquisition date, our results of operations include the operating results of Hospira. In accordance with our domestic and international reporting periods, our results of operations for 2015 reflect four months of legacy Hospira U.S. operations and three months of legacy Hospira international operations. See Note 2A for additional information. (b) Developed Europe region includes the following markets: Western Europe, Scandinavian countries and Finland. Revenues denominated in euros were $7.2 billion in 2016 , $7.4 billion in 2015 and $9.0 billion in 2014 . (c) Developed Rest of World region includes the following markets: Japan, Canada, Australia, South Korea and New Zealand. (d) Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Africa, Eastern Europe, Central Europe, the Middle East and Turkey. Long-lived assets by geographic region follow (a) : As of December 31, (MILLIONS OF DOLLARS) 2016 2015 2014 Property, plant and equipment, net United States $ 6,649 $ 7,072 $ 5,575 Developed Europe (b) 4,228 4,376 4,606 Developed Rest of World (c) 643 660 617 Emerging Markets (d) 1,797 1,658 963 Property, plant and equipment, net $ 13,318 $ 13,766 $ 11,762 (a) Reflects legacy Medivation and legacy Anacor amounts in 2016, commencing on the Medivation acquisition date, September 28, 2016, and Anacor acquisition date, June 24, 2016. Reflects legacy Hospira amounts in 2016 and 2015 commencing on the Hospira acquisition date, September 3, 2015. (b) Developed Europe region includes the following markets: Western Europe, Scandinavian countries and Finland. (c) Developed Rest of World region includes the following markets: Japan, Canada, Australia, South Korea and New Zealand. Emerging Markets region includes, but is not limited to, the following markets: Asia (excluding Japan and South Korea), Latin America, Africa, Eastern Europe, Central Europe, the Middle East and Turkey. C. Other Revenue Information Significant Customers We sell our biopharmaceutical products primarily to customers in the wholesale sector. In 2016 , sales to our three largest U.S. wholesaler customers represented approximately 16% , 12% and 10% of total revenues, respectively, and, collectively, represented approximately 29% of total trade accounts receivable as of December 31, 2016 . In 2015, sales to our three largest U.S. wholesaler customers represented approximately 14% , 11% and 10% of total revenues, respectively, and, collectively, represented approximately 23% of total trade accounts receivable as of December 31, 2015 . In 2014, sales to our three largest U.S. wholesaler customers represented approximately 13% , 10% and 9% of total revenues, respectively, and, collectively, represented approximately 25% of total trade accounts receivable as of December 31, 2014 . For all years presented, these sales and related trade accounts receivable were concentrated in our biopharmaceutical businesses. Significant Product Revenues The following table provides detailed revenue information: Year Ended December 31, (MILLIONS OF DOLLARS) 2016 2015 2014 PFIZER INNOVATIVE HEALTH (IH) (a) $ 29,197 $ 26,758 $ 24,005 Internal Medicine $ 8,858 $ 7,611 $ 6,727 Lyrica IH (b) 4,165 3,655 3,350 Viagra IH (c) 1,181 1,297 1,181 Chantix/Champix 842 671 647 Toviaz 258 267 288 BMP2 251 232 228 Alliance revenues (d) 1,588 1,256 759 All other Internal Medicine (e) 573 233 276 Vaccines $ 6,071 $ 6,454 $ 4,480 Prevnar 13/Prevenar 13 5,718 6,245 4,464 FSME/IMMUN-TicoVac 114 104 — All other Vaccines 239 104 16 Oncology $ 4,563 $ 2,955 $ 2,218 Ibrance 2,135 723 — Sutent 1,095 1,120 1,174 Xalkori 561 488 438 Inlyta 401 430 410 Xtandi alliance revenues 140 — — All other Oncology 231 194 195 Inflammation & Immunology (I&I) $ 3,928 $ 3,918 $ 4,241 Enbrel (Outside the U.S. and Canada) 2,909 3,333 3,850 Xeljanz 927 523 308 All other I&I 93 61 82 Rare Disease $ 2,369 $ 2,425 2,893 BeneFIX 712 752 856 Genotropin 579 617 723 Refacto AF/Xyntha 554 533 631 Somavert 232 218 229 Rapamune 170 197 339 All other Rare Disease 122 108 114 Consumer Healthcare $ 3,407 $ 3,395 $ 3,446 PFIZER ESSENTIAL HEALTH (EH) (f) $ 23,627 $ 22,094 $ 25,600 Legacy Established Products (LEP) (g) $ 11,194 $ 11,745 $ 13,016 Lipitor 1,758 1,860 2,061 Premarin family 1,017 1,018 1,076 Norvasc 962 991 1,112 EpiPen 386 339 294 Xalatan/Xalacom 363 399 495 Relpax 323 352 382 Zoloft 304 374 423 Effexor 278 288 344 Zithromax/Zmax 272 275 311 Xanax/Xanax XR 222 224 253 Cardura 192 210 263 Neurontin 182 196 210 Tikosyn 153 179 141 Depo-Provera 126 170 201 Diflucan 119 181 208 All other LEP 4,538 4,689 5,242 Sterile Injectable Pharmaceuticals (SIP) (h) $ 6,018 $ 3,944 $ 3,277 Medrol 450 402 381 Sulperazon 396 339 354 Fragmin 318 335 364 Tygacil 274 304 323 All other SIP 4,579 2,563 1,855 Year Ended December 31, (MILLIONS OF DOLLARS) 2016 2015 2014 Peri-LOE Products (i) $ 4,220 $ 5,326 $ 8,855 Lyrica EH (b) 801 1,183 1,818 Celebrex 733 830 2,699 Pristiq 732 715 737 Vfend 590 682 756 Zyvox 421 883 1,352 Viagra EH (c) 383 411 504 Revatio 285 260 276 All Other Peri-LOE Products 276 362 714 Infusion Systems (j) $ 1,158 $ 403 $ — Biosimilars (k) $ 319 $ 63 $ — Inflectra/Remsima 192 30 — All Other Biosimilars 127 33 — Pfizer CentreOne (l) $ 718 $ 612 $ 451 Revenues $ 52,824 $ 48,851 $ 49,605 Total Lyrica (b) $ 4,966 $ 4,839 $ 5,168 Total Viagra (c) $ 1,564 $ 1,708 $ 1,685 Total Alliance revenues $ 1,746 $ 1,312 $ 957 (a) The IH business, previously known as the Innovative Products business, encompasses Internal Medicine, Vaccines, Oncology, Inflammation & Immunology, Rare Disease and Consumer Healthcare and includes all legacy Anacor and Medivation commercial operations. Anacor's and Medivation's commercial operations are included in IH's operating results in our consolidated statements of income, commencing from the acquisition date of June 24, 2016 for Anacor and from the acquisition date of September 28, 2016 for Medivation. As a result, IH's revenues for 2016 reflect approximately six months of legacy Anacor operations, which were immaterial, and three months of legacy Medivation operations. (b) Lyrica revenues from all of Europe, Russia, Turkey, Israel and Central Asia countries are included in Lyrica EH. All other Lyrica revenues are included in Lyrica IH. Total Lyrica revenues represent the aggregate of worldwide revenues from Lyrica IH and Lyrica EH. (c) Viagra revenues from the U.S. and Canada are included in Viagra IH. All other Viagra revenues are included in Viagra EH. Total Viagra revenues represent the aggregate of worldwide revenues from Viagra IH and Viagra EH. (d) Includes Eliquis for all years presented and Rebif for 2015 and 2014. (e) Includes Eliquis direct sales markets. (f) The EH business, previously known as the Established Products business, encompasses Legacy Established Products, Sterile Injectable Pharmaceuticals, Peri-LOE Products, Infusion Systems (through February 2, 2017), Biosimilars and Pfizer CentreOne and includes all legacy Hospira commercial operations. Hospira's commercial operations, including the legacy Hospira One-2-One sterile injectables contract manufacturing business, are included in EH’s operating results in our consolidated statements of income, commencing from the acquisition date of September 3, 2015. Therefore, in accordance with our domestic and international reporting periods, our results of operations and EH's operating results for 2015 reflect four months of legacy Hospira U.S. operations and three months of legacy Hospira international operations. Also, effective as of the beginning of 2016, our contract manufacturing business, Pfizer CentreOne, is part of EH. Pfizer CentreOne consists of (i) legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation (previously known as Pfizer CentreSource or PCS), including our manufacturing and supply agreements with Zoetis, which prior to 2016 was managed outside EH as part of PGS and previously reported in “Other Unallocated” costs; and (ii) legacy Hospira's One-2-One sterile injectables contract manufacturing operation. We have reclassified prior period PCS revenues ( $506 million in 2015 and $253 million in 2014) to conform to the current period presentation as part of EH. (g) Legacy Established Products include products that have lost patent protection (excluding Sterile Injectable Pharmaceuticals and Peri-LOE Products). (h) Sterile Injectable Pharmaceuticals include generic injectables and proprietary specialty injectables (excluding Peri-LOE Products). (i) Peri-LOE Products include products that have recently lost or are anticipated to soon lose patent protection. These products primarily include Lyrica in certain developed Europe markets, Pristiq globally, Celebrex, Zyvox and Revatio in most developed markets, Vfend and Viagra in certain developed Europe markets and Japan, and Inspra in the EU. (j) Infusion Systems (through February 2, 2017) include Medication Management Systems products composed of infusion pumps and related software and services, as well as IV Infusion Products, including large volume IV solutions and their associated administration sets. (k) Biosimilars include Inflectra/Remsima (biosimilar infliximab) in the U.S. and certain international markets, Nivestim (biosimilar filgrastim) in certain European, Asian and Africa/Middle East markets and Retacrit (biosimilar epoetin zeta) in certain European and Africa/Middle East markets. (l) Pfizer CentreOne includes (i) revenues from legacy Pfizer's contract manufacturing and active pharmaceutical ingredient sales operation (previously known as Pfizer CentreSource or PCS), including revenues related to our manufacturing and supply agreements with Zoetis; and (ii) revenues from legacy Hospira’s One-2-One sterile injectables contract manufacturing operation. We performed certain reclassifications, primarily between Legacy Established and Sterile Injectable Pharmaceuticals, to conform to current period presentation. |