Document and Entity Information
Document and Entity Information - shares | 3 Months Ended | |
Mar. 31, 2017 | May 05, 2017 | |
Document And Entity Information [Abstract] | ||
Entity Registrant Name | XOMA Corp | |
Trading Symbol | XOMA | |
Entity Central Index Key | 791,908 | |
Current Fiscal Year End Date | --12-31 | |
Entity Well-known Seasoned Issuer | No | |
Entity Filer Category | Accelerated Filer | |
Entity Common Stock, Shares Outstanding | 7,585,656 | |
Document Fiscal Year Focus | 2,017 | |
Document Fiscal Period Focus | Q1 | |
Document Type | 10-Q | |
Amendment Flag | false | |
Document Period End Date | Mar. 31, 2017 |
CONDENSED CONSOLIDATED BALANCE
CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | ||
Current assets: | ||||
Cash and cash equivalents | $ 20,045 | $ 25,742 | [1] | |
Trade and other receivables, net | 1,343 | 566 | [1] | |
Prepaid expenses and other current assets | 264 | 852 | [1] | |
Total current assets | 21,652 | 27,160 | [1] | |
Property and equipment, net | 396 | 1,036 | [1] | |
Other assets | 481 | 481 | [1] | |
Total assets | 22,529 | 28,677 | [1] | |
Current liabilities: | ||||
Accounts payable | 4,176 | 5,689 | [1] | |
Accrued and other liabilities | 2,173 | 4,215 | [1] | |
Accrued restructuring costs | 1,793 | 3,594 | [1] | |
Deferred revenue – current | 1,381 | 899 | [1] | |
Interest bearing obligations – current | 12,544 | 17,855 | [1] | |
Accrued interest on interest bearing obligations – current | 178 | 254 | [1] | |
Total current liabilities | 22,245 | 32,506 | [1] | |
Deferred revenue – non-current | 17,408 | 18,000 | [1] | |
Interest bearing obligations – non-current | 14,085 | 25,312 | [1] | |
Other liabilities – non-current | [1] | 69 | ||
Total liabilities | 53,738 | 75,887 | [1] | |
Commitments and Contingencies (Note 10) | [1] | |||
Stockholders’ deficit: | ||||
Preferred stock, $0.05 par value, 1,000,000 shares authorized, 5,003 and 0 shares issued and outstanding as of March 31, 2017 and December 31, 2016, respectively | [1] | |||
Common stock, $0.0075 par value, 277,333,332 shares authorized, 7,585,629 and 6,114,145 shares issued and outstanding at March 31, 2017 and December 31, 2016, respectively | 57 | 46 | [1] | |
Additional paid-in capital | 1,173,104 | 1,146,357 | [1] | |
Accumulated deficit | (1,204,370) | (1,193,613) | [1] | |
Total stockholders’ deficit | (31,209) | (47,210) | [1] | |
Total liabilities and stockholders’ deficit | $ 22,529 | $ 28,677 | [1] | |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
CONDENSED CONSOLIDATED BALANCE3
CONDENSED CONSOLIDATED BALANCE SHEETS (unaudited) (Parenthetical) - $ / shares | Mar. 31, 2017 | Dec. 31, 2016 |
Statement Of Financial Position [Abstract] | ||
Preferred stock, par value (in dollars per share) | $ 0.05 | $ 0.05 |
Preferred stock, shares authorized (in shares) | 1,000,000 | 1,000,000 |
Preferred stock, shares issued (in shares) | 5,003 | 0 |
Preferred stock, shares outstanding (in shares) | 5,003 | 0 |
Common stock, par value (in dollars per share) | $ 0.0075 | $ 0.0075 |
Common stock, shares authorized (in shares) | 277,333,332 | 277,333,332 |
Common stock, shares issued (in shares) | 7,585,629 | 6,114,145 |
Common stock, shares outstanding (in shares) | 7,585,629 | 6,114,145 |
CONDENSED CONSOLIDATED STATEMEN
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE LOSS (unaudited) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Revenues: | ||
License and collaborative fees | $ 150 | $ 2,491 |
Contract and other | 110 | 1,471 |
Total revenues | 260 | 3,962 |
Operating expenses: | ||
Research and development | 3,993 | 13,610 |
General and administrative | 5,167 | 4,305 |
Restructuring | 2,020 | 36 |
Total operating expenses | 11,180 | 17,951 |
Loss from operations | (10,920) | (13,989) |
Other income (expense): | ||
Interest expense | (609) | (1,002) |
Other income (expense), net | 1,329 | (306) |
Revaluation of contingent warrant liabilities | 6,932 | |
Loss on extinguishment of debt | (515) | |
Net loss | (10,715) | (8,365) |
Deemed dividend on convertible preferred stock | (5,603) | |
Net loss available to common stockholders | $ (16,318) | $ (8,365) |
Basic and diluted net loss per share available to common stockholders | $ (2.37) | $ (1.40) |
Weighted average shares used in computing basic and diluted net loss per share available to common stockholders | 6,887 | 5,978 |
Other comprehensive loss: | ||
Net loss | $ (10,715) | $ (8,365) |
Net unrealized loss on marketable securities | (42) | |
Total comprehensive loss | $ (10,715) | $ (8,407) |
CONDENSED CONSOLIDATED STATEME5
CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS (unaudited) - USD ($) $ in Thousands | 3 Months Ended | ||
Mar. 31, 2017 | Mar. 31, 2016 | ||
Cash flows used in operating activities: | |||
Net loss | $ (10,715) | $ (8,365) | |
Adjustments to reconcile net loss to net cash used in operating activities: | |||
Depreciation and amortization | 147 | 215 | |
Common stock contribution to 401(k) | 506 | 785 | |
Stock-based compensation expense | 1,000 | 2,306 | |
Revaluation of contingent warrant liabilities | (6,932) | ||
Amortization of debt issuance costs, debt discount and final payment fee on debt | 286 | 354 | |
Loss on extinguishment of debt | 515 | ||
Gain on sale of equipment | (1,314) | ||
Unrealized loss on foreign currency exchange | 261 | 559 | |
Other | 55 | (2) | |
Changes in assets and liabilities: | |||
Trade and other receivables, net | 33 | 2,092 | |
Prepaid expenses and other current assets | 345 | 415 | |
Accounts payable and accrued liabilities | (3,480) | (4,580) | |
Accrued restructuring costs | (1,801) | (321) | |
Accrued interest on interest bearing obligations | (76) | (6) | |
Deferred revenue | (110) | (2,306) | |
Other liabilities | (500) | ||
Net cash used in operating activities | (14,348) | (16,286) | |
Cash flows from investing activities: | |||
Proceeds from sale of equipment | 813 | ||
Purchase of property and equipment | (31) | ||
Net cash provided by (used in) investing activities | 813 | (31) | |
Cash flows from financing activities: | |||
Proceeds from issuance of common and preferred stock, net of issuance costs | 25,452 | ||
Principal payments ─ debt | (16,380) | (3,271) | |
Payment of final fee related to loan extinguishment | (1,150) | ||
Principal payments ─ capital lease | (51) | (28) | |
Net cash provided by (used in) financing activities | 7,871 | (3,299) | |
Effect of exchange rate changes on cash | (33) | 2 | |
Net decrease in cash and cash equivalents | (5,697) | (19,614) | |
Cash and cash equivalents at the beginning of the period | 25,742 | [1] | 65,767 |
Cash and cash equivalents at the end of the period | 20,045 | 46,153 | |
Supplemental Cash Flow Information: | |||
Cash paid for interest | 396 | $ 646 | |
Non-cash investing and financing activities: | |||
Other receivables related to the sale of equipment | $ 811 | ||
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Description of Business
Description of Business | 3 Months Ended |
Mar. 31, 2017 | |
Description Of Business [Abstract] | |
Description of Business | 1. Description of Business XOMA Corporation (referred to as “XOMA” or the “Company”), a Delaware corporation, has a long history of discovering and developing innovative therapeutics derived from its unique platform of antibody technologies. The Company has typically sought to license these therapeutic assets to licensees who take on the responsibilities of later stage development, approval and commercialization. In addition, XOMA has licensed antibody technologies on a non-exclusive basis to other companies who desire to access this platform for their own discovery efforts. In 2016, XOMA dedicated its research and development efforts to advancing its portfolio of product candidates that have the potential to treat a variety of endocrine diseases, including advancing the development of X358 for the treatment of congenital hyperinsulinism and hypoglycemia in hyperinsulinemic patients following bariatric surgery. XOMA’s strategy has evolved and its current focus is on developing or acquiring revenue generating assets and coupling them with a lean corporate infrastructure. As XOMA’s business model is based on the objective of out-licensing assets to other pharmaceutical companies for them to commercialize and market any resultant products, the Company expects that a significant portion of any future revenue will be based on payments it may receive from its licensees. Going Concern The Company has incurred operating losses since its inception resulting in an accumulated deficit of $1.2 billion, has a working capital deficiency of $0.6 million and $26.6 million in total outstanding debt at March 31, 2017. Management expects operating losses and negative cash flows to continue for the foreseeable future and, as a result, the Company will require additional capital to fund its operations and execute its business plan. As of March 31, 2017, the Company had $20.0 million in cash and cash equivalents, which is available to fund future operations. Taking into account the repayment of its outstanding debt classified within current liabilities on the Company’s condensed consolidated balance sheet as of March 31, 2017, without the receipt of additional funds from license and collaboration agreements or additional equity or debt financing, it will only be able to fund its operations and make scheduled loan payments into January 2018. Therefore, the Company determined there is substantial doubt about its ability to continue as a going concern. The analysis used to determine the Company’s ability to continue as a going concern does not include cash sources outside of XOMA’s direct control that management expects to be available within the next twelve months. The Company may not be able to obtain sufficient additional funding through monetizing certain of its existing assets, entering into new license agreements, issuing additional equity or debt instruments or any other means, and if it is able to do so, they may not be on satisfactory terms. The Company’s ability to raise additional capital in the equity and debt markets, should the Company choose to do so, is dependent on a number of factors, including, but not limited to, the market demand for the Company’s common stock, which itself is subject to a number of pharmaceutical development and business risks and uncertainties, as well as the uncertainty that the Company would be able to raise such additional capital at a price or on terms that are favorable to the Company. Consistent with the actions the Company has taken in the past, including the restructuring in December 2016 and February 2017, it will take steps intended to enable the continued operation of the business which may include out-licensing or sale of assets and reducing other expenditures that are within the Company’s control. These reductions in expenditures may have a material adverse impact on the Company’s ability to achieve certain of its planned objectives. Even if the Company is able to source additional funding, it may be forced to significantly further reduce its operations if its business prospects do not improve. If the Company is unable to source additional funding, it may be forced to shut down operations altogether. These condensed consolidated financial statements have been prepared on a going concern basis and do not include any adjustments to the amounts and classification of assets and liabilities that may be necessary in the event the Company can no longer continue as a going concern. Reverse Stock Split In October 2016, the Company’s stockholders voted at a special meeting of stock holders to approve a series of alternate amendments to the Company’s Amended Certificate of Incorporation to effect a reverse stock split of the Company’s issued and outstanding common stock. The Company’s Board of Directors then approved a specific ratio of 1-for-20. The par value per share of the Company’s common stock remained at $0.0075. The financial statements have been retroactively adjusted to reflect the reverse stock split for all periods presented. |
Basis of Presentation and Signi
Basis of Presentation and Significant Accounting Policies | 3 Months Ended |
Mar. 31, 2017 | |
Accounting Policies [Abstract] | |
Basis of Presentation and Significant Accounting Policies | 2. Basis of Presentation and Significant Accounting Policies Basis of Presentation The condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions among consolidated entities were eliminated upon consolidation. The unaudited consolidated financial statements were prepared in accordance with generally accepted accounting principles (“GAAP”) in the United States for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. As permitted under those rules certain footnotes or other financial information can be condensed or omitted. These financial statements and related disclosures have been prepared with the assumption that users of the interim financial information have read or have access to the audited consolidated financial statements for the preceding fiscal year. Accordingly, these statements should be read in conjunction with the audited consolidated financial statements and related notes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016, filed with the U.S. Securities and Exchange Commission (“SEC”) on March 16, 2017. These financial statements have been prepared on the same basis as the Company’s annual consolidated financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments that are necessary for a fair statement of the Company’s consolidated financial information. The interim results of operations are not necessarily indicative of the results that may be expected for the full year. Use of Estimates The preparation of financial statements in conformity with GAAP in the United States requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosures. On an ongoing basis, management evaluates its estimates including, but not limited to, those related to revenue recognition, debt amendments, research and development expense, long-lived assets, restructuring liabilities, legal contingencies, and stock-based compensation. The Company bases its estimates on historical experience and on various other market-specific and other relevant assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ significantly from these estimates, such as the Company’s billing under government contracts and the Company’s accrual for clinical trial expenses. Under the Company’s contracts with the National Institute of Allergy and Infectious Diseases (“NIAID”), a part of the National Institutes of Health (“NIH”), the Company bills using NIH provisional rates and thus is subject to future audits at the discretion of NIAID’s contracting office. These audits can result in an adjustment to revenue previously reported which potentially could be significant. In March 2016, the Company effected the novation of its remaining active contract with NIAID to Nanotherapeutics, Inc. (“Nanotherapeutics”) (see Note 6). The billings made prior to the effective date of the novation of such contract are still subject to future audits, which may result in significant adjustments to reported revenues. The Company’s accrual for clinical trials is based on estimates of the services received and efforts expended under contracts with clinical trial centers and clinical research organizations. Revenue Recognition Revenue is recognized when the four basic criteria of revenue recognition are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the fee is fixed or determinable; and (4) collectability is reasonably assured. The determination of criteria (2) is based on management’s judgments regarding whether a continuing performance obligation exists. The determination of criteria (3) and (4) are based on management’s judgments regarding the nature of the fee charged for products or services delivered and the collectability of those fees. Allowances are established for estimated uncollectible amounts, if any. The Company recognizes revenue from its license and collaboration arrangements, contract services, and royalties. Revenue arrangements with multiple elements are divided into separate units of accounting if certain criteria are met, including whether the delivered element has stand-alone value to the customer and whether there is objective and reliable evidence of the fair value of the undelivered items. Each deliverable in the arrangement is evaluated to determine whether it meets the criteria to be accounted for as a separate unit of accounting or whether it should be combined with other deliverables. In order to account for the multiple-element arrangements, the Company identifies the deliverables included within the arrangement and evaluates which deliverables represent separate units of accounting. Analyzing the arrangement to identify deliverables requires the use of judgment, and each deliverable may be an obligation to deliver services, a right or license to use an asset, or another performance obligation. The consideration received is allocated among the separate units of accounting based on their respective fair values and the applicable revenue recognition criteria are applied to each of the separate units. Advance payments received in excess of amounts earned are classified as deferred revenue until earned. License and Collaborative Fees Revenue from non-refundable license, technology access or other payments under license and collaborative agreements where the Company has a continuing obligation to perform is recognized as revenue over the estimated period of the continuing performance obligation. The Company estimates the performance period at the inception of the arrangement and reevaluates it each reporting period. Management makes its best estimate of the period over which it expects to fulfill the performance obligations, which may include clinical development activities. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the performance period. This reevaluation may shorten or lengthen the period over which the remaining revenue is recognized. Changes to these estimates are recorded on a prospective basis. License and collaboration agreements with certain third parties also provide for contingent payments to be paid to the Company based solely upon the performance of the partner. For such contingent payments, revenue is recognized upon completion of the milestone event, once confirmation is received from the third party, provided that collection is reasonably assured and the other revenue recognition criteria have been satisfied. Milestone payments that are not substantive or that require a continuing performance obligation on the part of the Company are recognized over the expected period of the continuing performance obligation. Amounts received in advance are recorded as deferred revenue until the related milestone is completed. Payment related to an option to purchase the Company’s commercialization rights is considered substantive if, at the inception of the arrangement, the Company is at risk as to whether the collaboration partner will choose to exercise the option. Factors that the Company considers in evaluating whether an option is substantive include the overall objective of the arrangement, the benefit the collaborator might obtain from the arrangement without exercising the option, the cost to exercise the option and the likelihood that the option will be exercised. For arrangements under which an option is considered substantive, the Company does not consider the item underlying the option to be a deliverable at the inception of the arrangement and the associated option fees are not included in allocable arrangement consideration, assuming the option is not priced at a significant and incremental discount. Conversely, for arrangements under which an option is not considered substantive or if an option is priced at a significant and incremental discount, the Company would consider the item underlying the option to be a deliverable at the inception of the arrangement and a corresponding amount would be included in allocable arrangement consideration. Contract and Other Revenues Contract revenue for research and development involves the Company providing research and development services to collaborative parties or others. Cost reimbursement revenue under collaborative agreements is recorded as contract and other revenues and is recognized as the related research and development costs are incurred, as provided for under the terms of these agreements. Revenue for certain contracts is accounted for by a proportional performance, or output-based, method where performance is based on estimated progress toward elements defined in the contract. The amount of contract revenue and related costs recognized in each accounting period are based on management’s estimates of the proportional performance during the period. Adjustments to estimates based on actual performance are recognized on a prospective basis and do not result in reversal of revenue should the estimate to complete be extended. Up-front fees associated with contract revenue are recorded as license and collaborative fees and are recognized in the same manner as the final deliverable, which is generally ratably over the period of the continuing performance obligation. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the arrangement. Royalty revenue and royalty receivables are recorded in the periods these royalty amounts are earned, if estimable and collectability is reasonably assured. The royalty revenue and receivables recorded in these instances are based upon communication with the Company’s licensees, historical information and forecasted sales trends. Sale of Future Revenue Streams The Company has sold its rights to receive certain milestones and royalties on product sales. In the circumstance where the Company has sold its rights to future milestones and royalties under a license agreement and also maintains limited continuing involvement in the arrangement (but not significant continuing involvement in the generation of the cash flows that are due to the purchaser), the Company defers recognition of the proceeds it receives for the sale of milestone or royalty stream and recognizes such deferred revenue as contract and other revenue over the life of the underlying license agreement. The Company recognizes this revenue under the "units-of-revenue" method. Under this method, amortization for a reporting period is calculated by computing a ratio of the proceeds received from the purchaser to the total payments expected to be made to the purchaser over the term of the agreement, and then applying that ratio to the period’s cash payment. Estimating the total payments expected to be received by the purchaser over the term of such arrangements requires management to use subjective estimates and assumptions. Changes to the Company’s estimate of the payments expected to be made to the purchaser over the term of such arrangements could have a material effect on the amount of revenues recognized in any particular period. Research and Development Expenses The Company expenses research and development costs as incurred. Research and development expenses consist of direct costs such as salaries and related personnel costs, and material and supply costs, and research-related allocated overhead costs, such as facilities costs. In addition, research and development expenses include costs related to clinical trials. From time to time, research and development expenses may include up-front fees and milestones paid to collaborative partners for the purchase of rights to in-process research and development. Such amounts are expensed as incurred. The Company’s accrual for clinical trials is based on estimates of the services received and efforts expended under contracts with clinical trial centers and clinical research organizations. The Company may terminate these contracts upon written notice and is generally only liable for actual effort expended by the organizations to the date of termination, although in certain instances the Company may be further responsible for termination fees and penalties. The Company makes estimates of its accrued expenses as of each balance sheet date based on the facts and circumstances known to the Company at that time. Expenses resulting from clinical trials are recorded when incurred, based in part on estimates as to the status of the various trials. Stock-Based Compensation The Company recognizes compensation expense for all stock-based payment awards made to the Company’s employees, consultants and directors that are expected to vest based on estimated fair values. The valuation of stock option awards is determined at the date of grant using the Black-Scholes Option Pricing Model (the “Black-Scholes Model”). The Black-Scholes Model requires inputs such as the expected term of the option, expected volatility and risk-free interest rate. To establish an estimate of expected term, the Company considers the vesting period and contractual period of the award and its historical experience of stock option exercises, post-vesting cancellations and volatility. The estimate of expected volatility is based on the Company’s historical volatility. The risk-free rate is based on the yield available on United States Treasury zero-coupon issues corresponding to the expected term of the award. The valuation of restricted stock units (“RSUs”) is determined at the date of grant using the Company’s closing stock price. In January 2017, the Company adopted Accounting Standards Update (“ASU”) No. 2016-09, Compensation—Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting, Restructuring and Impairment Charges Restructuring costs are primarily comprised of severance costs related to workforce reductions, contract termination costs and asset impairments. The Company recognizes restructuring charges when the liability has been incurred, except for employee termination benefits that are incurred over time. Generally, employee termination benefits (i.e., severance costs) are accrued at the date management has committed to a plan of termination and employees have been notified of their termination dates and expected severance payments. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations and the timing of employees leaving the Company. Other costs, including contract termination costs, are recorded when the arrangement is terminated. Asset impairment charges have been, and will be, recognized when management has concluded that the assets have been impaired. Warrants The Company has issued warrants to purchase shares of its common stock in connection with financing activities. The Company accounted for some of these warrants as a liability at fair value and others as equity at fair value. The fair value of the outstanding warrants was estimated using the Black-Scholes Model. The Black-Scholes Model required inputs such as the expected term of the warrants, expected volatility and risk-free interest rate. These inputs were subjective and required significant analysis and judgment to develop. For the estimate of the expected term, the Company used the full remaining contractual term of the warrant. The Company determined the expected volatility assumption in the Black-Scholes Model based on historical stock price volatility observed on the Company’s underlying stock. The assumptions associated with contingent warrant liabilities were reviewed each reporting period and changes in the estimated fair value of these contingent warrant liabilities were recognized in revaluation of contingent warrant liabilities within the consolidated statements of comprehensive loss. Net Loss per Share Available to Common Stockholders Basic net loss per share available to common stockholders is based on the weighted average number of shares of common stock outstanding during the period. Net loss available to common stockholders consists of net loss, as adjusted for the convertible preferred stock deemed dividends related to the beneficial conversion feature on this instrument at issuance. Diluted net loss per share available to common stockholders is based on the weighted average number of shares outstanding during the period, adjusted to include the assumed conversion of preferred stock, certain stock options, RSUs, and warrants for common stock. The calculation of diluted loss per share available to common stockholders requires that, to the extent the average market price of the underlying shares for the reporting period exceeds the exercise price of the warrants and the presumed exercise of such securities are dilutive to earnings (loss) per share available to common stockholders for the period, adjustments to net loss used in the calculation are required to remove the change in fair value of the warrants for the period. Likewise, adjustments to the denominator are required to reflect the related dilutive shares. Concentration of Risk Cash equivalents and receivables are financial instruments, which potentially subject the Company to concentrations of credit risk, as well as liquidity risk for certain cash equivalents, such as money market funds. The Company has not encountered any such liquidity issues during 2017. The Company has not experienced any significant credit losses and does not generally require collateral on receivables. For the three months ended March 31, 2017, two customers represented 58% and 42% of total revenues. For the three months ended March 31, 2016, three customers represented 38%, 27%, and 23% of total revenues. As of March 31, 2017, two customers represented 81% and 14% Recent Accounting Pronouncements In May 2014, the Financial Accounting Standards Board (“FASB”) issued guidance codified in Accounting Standards Codification (“ASC”) 606, Revenue Recognition — Revenue from Contracts with Customers Revenue Recognition In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842) |
Condensed Consolidated Financia
Condensed Consolidated Financial Statements Detail | 3 Months Ended |
Mar. 31, 2017 | |
Condensed Consolidated Financial Statements Detail [Abstract] | |
Condensed Consolidated Financial Statements Detail | 3. Condensed Consolidated Financial Statements Detail Cash and Cash Equivalents As of March 31, 2017, cash and cash equivalents consisted of demand deposits of $2.9 Property and Equipment, net Property and equipment, net consisted of the following (in thousands): March 31, December 31, 2017 2016 Equipment and furniture $ 2,691 $ 14,023 Leasehold improvements 554 554 3,245 14,577 Less: Accumulated depreciation and amortization (2,849 ) (13,541 ) Property and equipment, net $ 396 $ 1,036 During the three months ended March 31, 2017, the Company completed the sale of equipment located in one of its leased facilities for total proceeds of $1.6 million. Of the $1.6 million, $0.8 million is included in other receivables as of March 31, 2017. The carrying value of the equipment sold was $0.3 million. Accordingly, the Company recorded a gain of $1.3 million on the sale of equipment in the other income (expense), net line of the condensed consolidated statement of comprehensive loss. Accrued and Other Liabilities Accrued and other liabilities consisted of the following (in thousands): March 31, December 31, 2017 2016 Accrued payroll and other benefits $ 123 $ 1,582 Accrued clinical trial costs 394 743 Accrued incentive compensation 203 — Accrued legal and accounting fees 670 385 Other 783 1,505 Total $ 2,173 $ 4,215 Net Loss Per Share Available to Common Stockholders The following is a reconciliation of the numerator (net loss) and the denominator (number of shares) used in the calculation of basic and diluted net loss per share available to common stockholders (in thousands): Three Months Ended March 31, 2017 2016 Numerator Net loss $ (10,715 ) $ (8,365 ) Deemed dividend on convertible preferred stock (5,603 ) — Net loss available to common stockholders, basic and diluted $ (16,318 ) $ (8,365 ) Denominator Weighted average shares outstanding used for basic and diluted net loss per share available to common stockholders 6,887 5,978 Potentially dilutive securities are excluded from the calculation of diluted net loss per share available to common stockholders if their inclusion is anti-dilutive. The following table shows the weighted-average outstanding securities considered anti-dilutive and therefore excluded from the computation of diluted net loss per share available to common stockholders (in thousands): Three Months Ended March 31, 2017 2016 Convertible preferred stock (as converted) 2,446 — Common stock options and RSUs 653 535 Warrants for common stock 381 911 Total 3,480 1,446 |
Collaborative, Licensing and Ot
Collaborative, Licensing and Other Arrangements | 3 Months Ended |
Mar. 31, 2017 | |
Collaborative Licensing And Other Arrangements [Abstract] | |
Collaborative, Licensing and Other Arrangements | 4. Collaborative, Licensing and Other Arrangements Servier In December 2010, the Company entered into a license and collaboration agreement (“Collaboration Agreement”) with Les Laboratories Servier (“Servier”), to jointly develop and commercialize gevokizumab in multiple indications. Under the terms of the agreement, Servier had worldwide rights to cardiovascular disease and diabetes indications and had rights outside the United States and Japan to all other indications, including non-infectious intermediate, posterior or pan-uveitis, Behçet’s disease uveitis, pyoderma gangrenosum, and other inflammatory and oncology indications. Under the Collaboration Agreement, Servier funded all activities to advance the global clinical development and future commercialization of gevokizumab in cardiovascular-related diseases and diabetes. Also, Servier funded the first $50.0 million of gevokizumab global clinical development and chemistry, manufacturing and controls expenses related to the three pivotal clinical trials under the EYEGUARD program. All remaining expenses related to these three pivotal clinical trials were shared equally between Servier and the Company. On September 28, 2015, Servier notified XOMA of its intention to terminate the Collaboration Agreement, as amended in January 2015, and return the gevokizumab rights to XOMA. The termination, which became effective on March 25, 2016, did not result in a change to the maturity date of the Company’s loan with Servier (see Note 8). As the Company was no longer required to provide services to Servier under the Collaboration Agreement, the Company recognized all remaining deferred revenue of $0.6 million from the date of notification to March 25, 2016. For the three months ended March 31, 2017 and 2016, the Company recorded revenue of zero and $0.3 million, respectively, from this Collaboration Agreement. NIAID In October 2011, the Company announced that NIAID had awarded the Company a new contract under Contract No. HHSN272201100031C (the “NIAID Contract”) for up to $28.0 million over five years to develop broad-spectrum antitoxins for the treatment of human botulism poisoning. The contract work was being performed on a cost-plus-fixed-fee basis over the life of the contract and the Company was recognizing revenue under the arrangement as the services were performed on a proportional- performance basis. In March 2016, the Company effected a novation of the NIAID Contract to Nanotherapeutics. The novation was effected upon obtaining government approval to transfer the NIAID Contract to Nanotherapeutics pursuant to the asset purchase agreement executed in November 2015 (see Note 6). The Company recognized revenue of zero and $1.1 million under this contract for the three months ended March 31, 2017 and 2016, respectively. Pfizer In August 2005, the Company entered into a license agreement with Wyeth (subsequently acquired by Pfizer, Inc. (“Pfizer”)) for non-exclusive, worldwide rights for certain of XOMA’s patented bacterial cell expression technology for vaccine manufacturing. Under the terms of this agreement, the Company received a milestone payment in November 2012 relating to TRUMENBA®, a meningococcal group B vaccine marketed by Pfizer. The Company received a fraction of a percentage of sales of TRUMENBA as royalties. The Company’s right to royalties expires on a country-by-country basis upon the expiration of the last-to-expire licensed patent. As discussed below under Sale of Future Revenue Streams, the Company sold its right to receive milestones and royalties on future sales of products to HealthCare Royalty Partners II, L.P. (“HCRP”) in connection with the Royalty Interest Acquisition Agreement entered into in December 2016. Sale of Future Revenue Streams On December 21, 2016, the Company entered into two Royalty Interest Acquisition Agreements (together, the “Acquisition Agreements”) with HCRP. Under the first Acquisition Agreement, the Company sold its right to receive milestone payments and royalties on future sales of products subject to a License Agreement, dated August 18, 2005, between XOMA and Wyeth Pharmaceuticals (now Pfizer) for an upfront cash payment of $6.5 million, plus potential additional payments totaling $4.0 million in the event three specified net sales milestones are met in 2017, 2018 and 2019. Under the second Acquisition Agreement, the Company sold all rights to royalties under an Amended and Restated License Agreement dated October 27, 2006 between XOMA and Dyax Corp. for a cash payment of $11.5 million. The Company classified the proceeds received from HCRP as deferred revenue, to be recognized as contract and other revenue over the life of the license agreements because of the Company's limited continuing involvement in the Acquisition Agreements. Such limited continuing involvement is related to the Company’s undertaking to cooperate with HCRP in the event of a litigation or dispute related to the license agreements. Because the transaction was structured as a non-cancellable sale, the Company does not have significant continuing involvement in the generation of the cash flows due to HCRP and there are no guaranteed rates of return to HCRP, the Company recorded the total proceeds of $18.0 million as deferred revenue. The Company allocated the total proceeds between the two Acquisition Agreements based on the relative fair value of expected payments to be made to HCRP under the license agreements. The deferred revenue is being recognized as contract and other revenue over the life of the underlying license agreements under the "units-of-revenue" method. Under this method, amortization for a reporting period is calculated by computing a ratio of the allocated proceeds received from HCRP to the payments expected to be made by the licensees to HCRP over the term of the Acquisition Agreements, and then applying that ratio to the period’s cash payment. The Company recognized $0.1 million as contract and other revenue under these arrangements during the three months ended March 31, 2017. As of March 31, 2017, the current and non-current portion of the remaining deferred revenue was $0.5 million and $17.4 million, respectively. As of December 31, 2016, the Company classified the $18.0 million as non-current deferred revenue. |
Fair Value Measurements
Fair Value Measurements | 3 Months Ended |
Mar. 31, 2017 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | 5. Fair Value Measurements The Company records its financial assets and liabilities at fair value. The carrying amounts of certain of the Company’s financial instruments, including cash and cash equivalents, trade receivables and accounts payable, approximate their fair value due to their short maturities. Fair value is defined as the exchange price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The accounting guidance for fair value establishes a framework for measuring fair value and a fair value hierarchy that prioritizes the inputs used in valuation techniques. The accounting standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value, which are the following: Level 1 – Observable inputs, such as quoted prices in active markets for identical assets or liabilities. Level 2 – Observable inputs, either directly or indirectly, other than quoted prices in active markets for identical assets or liabilities, such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Level 3 – Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities; therefore, requiring an entity to develop its own valuation techniques and assumptions. The following tables set forth the Company’s fair value hierarchy for its financial assets and liabilities measured at fair value on a recurring basis as follows (in thousands): Fair Value Measurements at March 31, 2017 Using Quoted Prices in Active Markets for Identical Assets Significant Other Observable Inputs Significant Unobservable Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds (1) $ 17,175 $ — $ — $ 17,175 Fair Value Measurements at December 31, 2016 Using Quoted Prices in Active Markets for Identical Assets Significant Other Observable Inputs Significant Unobservable Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds (1) $ 4,161 $ — $ — $ 4,161 (1) Included in cash and cash equivalents During the three-month period ended March 31, 2017, there were no transfers between Level 1, Level 2, or Level 3 assets or liabilities reported at fair value on a recurring basis and the valuation techniques used did not change compared to the Company’s established practice. The estimated fair value of the Company’s outstanding interest-bearing obligations is estimated using the net present value of the payments, discounted at an interest rate that is consistent with market interest rates, which is a Level 2 input. The carrying amount and the estimated fair value of the Company’s outstanding interest-bearing obligations at March 31, 2017, and December 31, 2016, are as follows (in thousands): March 31, 2017 December 31, 2016 Carrying Amount Estimated Fair Value Carrying Amount Estimated Fair Value Hercules term loan $ — $ — $ 16,850 $ 16,453 Novartis note 14,085 13,892 14,086 13,836 Servier loan 12,544 12,541 12,231 12,242 Total $ 26,629 $ 26,433 $ 43,167 $ 42,531 |
Disposition
Disposition | 3 Months Ended |
Mar. 31, 2017 | |
Dispositions [Abstract] | |
Disposition | 6. Disposition On November 4, 2015, XOMA and Nanotherapeutics entered into an asset purchase agreement under which Nanotherapeutics agreed to acquire XOMA’s biodefense business and related assets (including, subject to government approval, certain contracts with the U.S. government), and to assume certain liabilities of XOMA. As part of the transaction, the parties entered into an intellectual property license agreement (the “Nanotherapeutics License Agreement”), under which XOMA agreed to license to Nanotherapeutics certain intellectual property rights related to the purchased assets. Under the Nanotherapeutics License Agreement, the Company is eligible to receive contingent consideration up to a maximum of $4.5 million in cash and 23,008 shares of common stock of Nanotherapeutics, based upon Nanotherapeutics achieving certain specified future operational objectives. In addition, the Company is eligible to receive 15% royalties on net sales of any future Nanotherapeutics products covered by or involving the related patents or know-how. On March 17, 2016, the Company effected a novation of the NIAID Contract to Nanotherapeutics. On March 23, 2016, the Company completed the transfer of the NIAID Contract and certain related third-party service contracts and materials, and the grant of exclusive and non-exclusive licenses for certain of its patents and general know-how to Nanotherapeutics. The Company believes that the NIAID Contract and certain related third-party service contracts and materials related to the biodefense program transferred to Nanotherapeutics include a sufficient number of key inputs and processes necessary to generate output from a market participant’s perspective. Accordingly, the Company has determined that such assets qualify as a business. The transaction had no impact on the Company’s consolidated financial statements as of, and for the year ended, December 31, 2016. In February 2017, the Company executed an Amendment and Restatement to both the asset purchase agreement and Nanotherapeutics License Agreement primarily to (i) remove Nanotherapeutics’ obligation to issue 23,008 shares to the Company of its common stock under the asset purchase agreement, and (ii) revise the payment schedule related to the timing of the $4.5 million cash payments due to the Company under the Nanotherapeutics License Agreement. Of the $4.5 million, $3.0 million is contingent upon Nanotherapeutics achieving certain specified future operating objectives. As of March 31, 2017, based on the payment terms pursuant to the amended Nanotherapeutics License Agreement, the Company was entitled to receive $1.6 million. Of the $1.6 million, the Company received $150,000 in March 2017, which was recognized as other income in the condensed consolidated statement of comprehensive loss. As the amended Nanotherapeutics License Agreement involves extended payment terms, the remaining $1.5 million, due in quarterly installments through September 2018 will be recognized as other income as the payments are received. |
Restructuring Charges
Restructuring Charges | 3 Months Ended |
Mar. 31, 2017 | |
Restructuring And Related Activities [Abstract] | |
Restructuring Charges | 7. Restructuring Charges On December 19, 2016, the Board of Directors approved a restructuring of its business based on its decision to focus the Company’s efforts on clinical development, with an initial focus on the X358 clinical programs. The restructuring included a reduction-in-force in which the Company terminated 57 employees (the “2016 Restructuring”). In addition, effective December 21, 2016, the Company’s Chief Executive Officer retired from his position. In early 2017, the Company further revised its strategy to prioritize out-licensing activities and further curtail research and development spending (the “2017 Restructuring”), and the Company expects to eliminate five additional employees with an effective termination date of June 30, 2017. During the three months ended March 31, 2017, the Company recorded charges of $0.5 million and $1.5 million related to severance, other termination benefits and outplacement services in connection with the workforce reductions resulting from the 2017 Restructuring and 2016 Restructuring, respectively. In the first quarter of 2017, the Company paid a total of $3.8 million associated with the 2017 Restructuring and 2016 Restructuring activities. Of the remaining accrued restructuring of $1.8 million, the Company expects to pay $1.0 million in the second quarter of 2017 and the remaining $0.8 million related to executive severance will continue to be paid through March 2018. The following table summarizes the accrued restructuring costs on the condensed consolidated balance sheet as of March 31, 2017 (in thousands): Employee Severance and Other Benefits Balance at December 31, 2016 $ 3,594 Restructuring charges 2,020 Cash payments (3,821 ) Balance at March 31, 2017 $ 1,793 |
Long-Term Debt
Long-Term Debt | 3 Months Ended |
Mar. 31, 2017 | |
Debt Disclosure [Abstract] | |
Long-Term Debt | 8. Long-Term Debt Novartis Note In May 2005, the Company executed a secured note agreement (the “Note Agreement”) with Novartis AG (“Novartis”), which was due and payable in full in June 2015. Under the Note Agreement, the Company borrowed semi-annually to fund up to 75% of the Company’s research and development and commercialization costs under its collaboration arrangement with Novartis, not to exceed $50.0 million in aggregate principal amount. Interest on the principal amount of the loan accrued at six-month LIBOR plus 2%, which was equal to 3.32% at March 31, 2017 and is payable semi-annually in June and December of each year. Additionally, the interest rate resets in June and December of each year. At the Company’s election, the semi-annual interest payments could be added to the outstanding principal amount, in lieu of a cash payment, as long as the aggregate principal amount did not exceed $50.0 million. The Company made this election for all interest payments. Loans under the Note Agreement were secured by the Company’s interest in its collaboration with Novartis, including any payments owed to it thereunder. Pursuant to the terms of the arrangement as restructured in November 2008, the Company did not make any additional borrowings under the Novartis note. In June 2015, the Company and Novartis Vaccines and Diagnostics, Inc. (“NVDI”) agreed to extend the maturity date of the Note Agreement from June 21, 2015, to September 30, 2015 (the “June 2015 Extension Letter”). On September 30, 2015, concurrent with the execution of a license agreement with Novartis International Pharmaceutical Ltd., XOMA and NVDI executed an amendment to the June 2015 Extension Letter (the “Secured Note Amendment”) under which the parties further extended the maturity date of the June 2015 Extension Letter from September 30, 2015 to September 30, 2020, and eliminated the mandatory prepayment previously required to be made with certain proceeds of pre-tax profits and royalties. In addition, upon achievement of a specified development and regulatory milestone, the then-outstanding principal amount of the note will be reduced by $7.3 million rather than the Company receiving such amount as a cash payment. All other terms of the original Note Agreement remain unchanged. As of March 31, 2017 and December 31, 2016, the outstanding principal balance under this Secured Note Amendment was $14.1 million and $14.1 million, respectively, and was included in interest bearing obligations – non-current in the accompanying consolidated balance sheets. Servier Loan Agreement In December 2010, in connection with the Collaboration Agreement entered into with Servier, the Company executed a loan agreement with Servier (the “Servier Loan Agreement”), which provided for an advance of up to €15.0 million. The loan was fully funded in January 2011, with the proceeds converting to approximately $19.5 million. The loan is secured by an interest in XOMA’s intellectual property rights to gevokizumab and its use in indications worldwide, excluding certain rights in the U.S. and Japan. Interest is calculated at a floating rate based on a Euro Inter-Bank Offered Rate (“EURIBOR”) and subject to a cap. The interest rate is reset semi-annually in January and July of each year. Interest for the six-month period from mid-July 2016 through mid-January 2017 was reset to 1.81%. Interest for the six-month period from mid-January 2017 through mid-July 2017 was reset to 1.77%. Interest is payable semi-annually. On January 9, 2015, Servier and the Company entered into Amendment No. 2 (“Loan Amendment”) to the Servier Loan Agreement initially entered into on December 30, 2010 and subsequently amended by a Consent, Transfer, Assumption and Amendment Agreement entered into as of August 12, 2013. The Loan Amendment extended the maturity date of the loan from January 13, 2016 to three tranches of principal to be repaid as follows: €3.0 million on January 15, 2016, €5.0 million on January 15, 2017, and €7.0 million on January 15, 2018. All other terms of the Servier Loan Agreement remained unchanged. The loan will be immediately due and payable upon certain customary events of default. In January 2016, the Company made payments of €3.0 million in principal and €0.2 million in accrued interest to Servier. In January 2017, the Company entered into Amendment No. 3 to the Servier Loan Agreement. Amendment No. 3 extended the maturity date of the portion of the loan equal to €5.0 million due on January 15, 2017 to July 15, 2017. The other terms of the loan remained unchanged. The Company determined that Amendment No. 3 resulted in a debt modification. As a result, the loan will continue to be accounted for using the effective interest method, with a new effective interest rate based on revised cash flows calculated on a prospective basis upon the execution of the Amendment No. 3. Upon initial issuance, the loan had a stated interest rate lower than the market rate based on comparable loans held by similar companies, which represents additional value to the Company. The Company recorded this additional value as a discount to the carrying value of the loan amount, at its fair value of $8.9 million. The fair value of this discount, which was determined using a discounted cash flow model, represents the differential between the stated terms and rates of the loan, and market rates. Based on the association of the loan with the Collaboration Agreement, the Company recorded the offset to this discount as deferred revenue. The loan discount was amortized to interest expense under the effective interest method over the remaining life of the loan. The loan discount balance at the time of the Loan Amendment was $1.9 million, which was being amortized over the remaining term of the Loan Amendment. The loan discount balance at the time of Amendment No. 3 was $0.4 million, which is being amortized over the remaining term of the loan. The Company recorded non-cash interest expense resulting from the amortization of the loan discount of $0.1 million and $0.2 million, for the three months ended March 31, 2017 and 2016, respectively. At March 31, 2017 and December 31, 2016, the net carrying value of the loan was $12.5 million and $12.2 million, respectively. For the three months ended March 31, 2017 and 2016, the Company recorded unrealized foreign exchange gains of $6,000 and $38,000, respectively, related to the re-measurement of the loan discount. The outstanding principal balance under this loan was $12.8 million and $12.6 million, using a euro to US dollar exchange rate of 1.068 and 1.052, as of March 31, 2017 and December 31, 2016, respectively. The Company recorded unrealized foreign exchange losses of $0.2 million and $0.5 million for the three months ended March 31, 2017 and 2016, respectively, related to the re-measurement of the loan. Hercules Term Loan On February 27, 2015, the Company entered into a Loan and Security Agreement with Hercules Technology Growth Capital, Inc. (the “Hercules Term Loan”). The Hercules Term Loan had a variable interest rate that was the greater of either (i) 9.40% plus the prime rate as reported from time to time in The Wall Street Journal minus 7.25%, or (ii) 9.40%. The payments under the Hercules Term Loan were interest only until June 1, 2016. The interest-only period was followed by equal monthly payments of principal and interest amortized over a 30-month schedule through the scheduled maturity date of September 1, 2018. The Hercules Term Loan included customary affirmative and restrictive covenants, but did not include any financial maintenance covenants, and also included standard events of default, including payment defaults. Upon the occurrence of an event of default, a default interest rate of an additional 5% may have been applied to the outstanding loan balances, and Hercules may have declared all outstanding obligations immediately due and payable and taken such other actions as set forth in the Hercules Term Loan. The Company incurred debt issuance costs of $0.5 million in connection with the Hercules Term Loan As of December 31, 2016, the outstanding principal balance of the Hercules Term Loan was $17.5 million, and the net carrying value was $16.9 million. On March 21, 2017, the Hercules Term Loan was paid in full and the Company was not required to pay the 1% prepayment charge due pursuant to the terms of the loan. A loss on extinguishment of $0.5 million from the payoff of the Hercules Term Loan was recognized in the condensed consolidated statement of comprehensive loss during the three months ended March 31, 2017. In connection with the Hercules Term Loan, the Company issued unregistered warrants that entitle Hercules to purchase up to an aggregate of 9,063 unregistered shares of XOMA common stock at an exercise price equal to $66.20 per share. These warrants were exercisable immediately and have a five-year term expiring in February 2020. The warrants are classified in stockholders’ deficit on the condensed consolidated balance sheets. As of March 31, 2017, all of these warrants were outstanding. Payments of Interest Bearing Obligations Aggregate future principal and discounts of the Company’s total interest bearing obligations as of March 31, 2017, are as follows (in thousands): Nine months ending December 31, 2017 $ 5,454 Year ending December 31, 2018 7,545 Year ending December 31, 2019 — Year ending December 31, 2020 15,980 28,979 Less: interest, discount and issuance cost (2,350 ) 26,629 Less: interest bearing obligations – current (12,544 ) Interest bearing obligations – non-current $ 14,085 Interest Expense Amortization of debt issuance costs and discounts are included in interest expense. Interest expense in the condensed consolidated statements of comprehensive loss relates to the following debt instruments (in thousands ) Three Months Ended March 31, 2017 2016 Hercules term loan $ 311 $ 672 Servier loan 177 226 Novartis note 117 97 Other 4 7 Total interest expense $ 609 $ 1,002 |
Common Stock Warrants
Common Stock Warrants | 3 Months Ended |
Mar. 31, 2017 | |
Warrants And Rights Note Disclosure [Abstract] | |
Common Stock Warrants | 9. Common Stock Warrants As of March 31, 2017 and December 31, 2016, the following common stock warrants were outstanding: Issuance Date Expiration Date Balance Sheet Classification Exercise Price per Share March 31, 2017 December 31, 2016 March 2012 March 2017 Contingent warrant liability $ 35.20 — 479,277 September 2012 September 2017 Stockholders' deficit $ 70.80 1,967 1,967 February 2015 February 2020 Stockholders' deficit $ 66.20 9,063 9,063 February 2016 February 2021 Stockholders' deficit $ 15.40 8,249 8,249 19,279 498,556 In March 2012, in connection with an underwritten offering, the Company issued five-year warrants to purchase 741,729 shares of the Company’s common stock at an exercise price of $35.20 per share. These warrants contained provisions that were contingent on the occurrence of a change in control, which could conditionally obligate the Company to repurchase the warrants for cash in an amount equal to their estimated fair value using the Black-Scholes Model on the date of such change in control. Due to these provisions, the Company accounted for the warrants issued in March 2012 as a liability at estimated fair value. In addition, the estimated fair value of the liability related to the warrants was revalued at each reporting period until the earlier of the exercise of the warrants, at which time the liability would be reclassified to stockholders' equity at its then estimated fair value, or expiration of the warrants. In March 2017, all of these warrants expired unexercised. |
Legal Proceedings, Commitments
Legal Proceedings, Commitments and Contingencies | 3 Months Ended |
Mar. 31, 2017 | |
Commitments And Contingencies Disclosure [Abstract] | |
Legal Proceedings, Commitments and Contingencies | 10. Legal Proceedings, Commitments and Contingencies Collaborative Agreements, Royalties and Milestone Payments The Company has committed to make potential future “milestone” payments to third parties as part of licensing and development programs. Payments under these agreements become due and payable only upon the achievement of certain developmental, regulatory and commercial milestones. Because it is uncertain if and when these milestones will be achieved, such contingencies, aggregating up to $15.5 million (assuming one product per contract meets all milestones events) have not been recorded on the accompanying consolidated balance sheets. The Company is unable to determine precisely when and if payment obligations under the agreements will become due as these obligations are based on milestone events, the achievement of which is subject to a significant number of risks and uncertainties. Legal Proceedings On July 24, 2015, a purported securities class action lawsuit was filed in the United States District Court for the Northern District of California, captioned Markette v. XOMA Corp., et al. On October 1, 2015, a stockholder purporting to act on the behalf of the Company, filed a derivative lawsuit in the Superior Court of California for the County of Alameda, purportedly asserting claims on behalf of the Company against certain of officers and the members of Board of Directors of the Company, captioned Silva v. Scannon, et al. On November 16 and November 25, 2015, two derivative lawsuits were filed purportedly on the Company’s behalf in the United States District Court for the Northern District of California, captioned Fieser v. Van Ness, et al Csoka v. Varian, et al |
Stock-based Compensation
Stock-based Compensation | 3 Months Ended |
Mar. 31, 2017 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Stock-based Compensation | 11. Stock-based Compensation The Company grants qualified and non-qualified stock options, RSUs, common stock and other stock-based awards under various plans to directors, officers, employees and other individuals. Stock options are granted at exercise prices of not less than the fair market value of the Company’s common stock on the date of grant. Additionally, the Company has an Employee Stock Purchase Plan (“ESPP”) that allows employees to purchase Company shares at a purchase price equal to 85% of the lower of the fair market value of the Company’s common stock on the first trading day of the offering period or on the last day of the offering period. Stock Options The stock options generally vest monthly over four years for employees and one year for directors. Stock options held by employees who qualify for retirement age (defined as employees that are a minimum of 55 years of age and the sum of their age plus years of full-time employment with the Company exceeds 70 years) vest on the earlier of scheduled vest date or the date of retirement. Three Months Ended March 31, 2017 2016 Dividend yield 0 % 0 % Expected volatility 100 % 106 % Risk-free interest rate 1.95 % 1.27 % Expected term 5.6 years 5.6 years Stock option activity for the three months ended March 31, 2017, was as follows: Options Weighted Average Weighted Average Remaining Contractual Life (in years) Aggregate Intrinsic Value (in thousands) Outstanding at January 1, 2017 568,292 $ 77.70 Granted 15,222 4.67 Forfeited, expired or cancelled (23,813 ) 140.84 Outstanding at March 31, 2017 559,701 $ 73.03 6.92 $ 363 Exercisable at March 31, 2017 317,119 $ 119.38 4.99 $ 3 In February 2017, the Board of Directors approved a grant of 1,018,000 stock options to members of the board, executives, and non-executive employees, subject to approval by the Company’s stockholders of an increase in the available shares under the Amended and Restated 2010 Long Term Incentive and Stock Award Plan at the 2017 Annual Meeting of Stockholders. Restricted Stock Units RSUs generally vest annually over three years for employees and one year for directors. RSUs held by employees who qualify for retirement age (defined as employees that are a minimum of 55 years of age and the sum of their age plus years of full-time employment with the Company exceeds 70 years) vest on the earlier of scheduled vest date or the date of retirement. The valuation of RSUs is determined at the date of grant using the closing stock price. RSU activity for the three months ended March 31, 2017, is summarized below: Weighted- Number of Average Grant- Shares Date Fair Value Unvested at January 1, 2017 91,228 $ 39.82 Granted 11,799 $ 4.67 Vested (53,300 ) $ 37.88 Forfeited (15,040 ) $ 42.49 Unvested at March 31, 2017 34,687 $ 29.69 Stock-based Compensation Expense The following table shows total stock-based compensation expense for stock options, RSUs and ESPP in the condensed consolidated statements of comprehensive loss (in thousands): Three Months Ended March 31, 2017 2016 Research and development $ 441 $ 1,137 General and administrative 559 1,169 Total stock-based compensation expense $ 1,000 $ 2,306 |
Capital Stock
Capital Stock | 3 Months Ended |
Mar. 31, 2017 | |
Stockholders Equity Note [Abstract] | |
Capital Stock | 12. Capital Stock Biotechnology Value Fund Financing In February 2017, the Company sold 1,200,000 shares of its common stock and 5,003 shares of Series X convertible preferred stock directly to Biotechnology Value Fund, L.P. and certain of its affiliates (“BVF”) in a registered direct offering, for aggregate net cash proceeds of $24.9 million. BVF purchased the shares of common stock from the Company at a price of $4.03 per share, the closing stock price on the date of purchase. Each share of Series X convertible preferred stock has a stated value of $4,030 per share and is convertible into 1,000 shares of registered common stock based on a conversion price of $4.03 per share of common stock. The total number of shares of common stock issued upon conversion of all issued Series X convertible preferred stock will be 5,003,000 shares. Each share is convertible at the option of the holder at any time, provided that the holder will be prohibited from converting into common stock if, as a result of such conversion, the holder, together with its affiliates, would beneficially own a number of shares above a conversion blocker, which is initially set at 19.99% of the total common stock then issued and outstanding immediately following the conversion of such shares. As of March 31, 2017, BVF owned approximately 19.8% of the Company’s total outstanding shares, and if all of the Series X convertible preferred shares were converted, BVF would own 51.7% of the Company’s total outstanding common shares. As of March 31, 2017, none of the preferred stock has been converted into shares of the Company’s common stock. The designations, preferences, rights and limitations of the convertible preferred shares are set forth in a Certificate of Designation of Preferences, Rights and Limitations of Series X convertible preferred stock filed with the Delaware Secretary of State. Shares of Series X convertible preferred stock will generally have no voting rights, except as required by law and except that the consent of the holders of the outstanding Series X convertible preferred stock will be required to amend the terms of the Series X preferred stock and to approve certain corporate actions. In the event of the Company’s liquidation, dissolution or winding up, holders of Series X convertible preferred stock will participate, on a pro-rata basis, with any distribution of proceeds to holders of common stock. Holders of Series X convertible preferred stock are entitled to receive dividends on shares of Series X convertible preferred stock equal (on an as if converted to common stock basis) to and in the same form as dividends actually paid on the Company’s common stock or other junior securities. The Company evaluated the Series X convertible preferred stock for liability or equity classification under the applicable accounting guidance, and determined that equity treatment was appropriate because the Series X convertible preferred stock did not meet the definition of the liability instruments defined thereunder for convertible instruments. Specifically, the Series X convertible preferred shares are not mandatorily redeemable and do not embody an obligation to buy back the shares outside of the Company’s control in a manner that could require the transfer of assets. Additionally, the Company determined that the Series X convertible preferred stock would be recorded as permanent equity, not temporary equity, based on the relevant guidance given that they are not redeemable for cash or other assets (i) on a fixed or determinable date, (ii) at the option of the holder, and (iii) upon the occurrence of an event that is not solely within control of the Company. The Company has also evaluated the embedded conversion and redemption features within the Series X convertible preferred stock in accordance with the accounting guidance for derivatives. Based on this assessment, the Company determined that the conversion option is clearly and closely related to the equity host, and thus, bifurcation is not required. The contingent redemption feature was determined to not be clearly and closely related to the equity-like host; however, it met the criteria as a scope exception for derivative accounting. Therefore, the contingent redemption feature was also not bifurcated from the Series X convertible preferred stock. The fair value of the common stock into which the Series X convertible preferred stock is convertible exceeded the allocated purchase price of the Series X convertible preferred stock by $5.6 million on the date of issuance, as such the Company recorded a deemed dividend. The Company recognized the resulting beneficial conversion feature as a deemed dividend equal to the number of shares of Series X convertible preferred stock sold on February 16, 2017 multiplied by the difference between the fair value of the common stock and the Series X convertible preferred stock effective conversion price per share on that date. The dividend was reflected as a one-time, non-cash, deemed dividend to the holders of Series X convertible preferred stock on the date of issuance, which is the date the stock first became convertible. ATM Agreemen ts On November 12, 2015, the Company entered into an At Market Issuance Sales Agreement (the “2015 ATM Agreement”) with Cowen and Company, LLC (“Cowen”), under which the Company may offer and sell from time to time at its sole discretion shares of its common stock through Cowen as its sales agent, in an aggregate amount not to exceed $75 million. Cowen may sell the shares by any method permitted by law deemed to be an “at the market” offering as defined in Rule 415 of the Securities Act, including without limitation sales made directly on The NASDAQ Global Market, on any other existing trading market for the Company’s common stock or to or through a market maker. Cowen also may sell the shares in privately negotiated transactions, subject to the Company’s prior approval. The Company will pay Cowen a commission equal to 3% of the gross proceeds of the sales price of all shares sold through it as sales agent under the 2015 ATM Agreement. For the three months ended March 31, 2017, the Company sold a total of 110,252 shares of common stock under the ATM Agreement for aggregate gross proceeds of $0.6 million. Total offering costs of $0.2 million were offset against the proceeds upon sale of common stock. |
Subsequent Events
Subsequent Events | 3 Months Ended |
Mar. 31, 2017 | |
Subsequent Events [Abstract] | |
Subsequent Events | 13. Subsequent Events On April 20, 2017, the Company received notice from Novo Nordisk A/S regarding the termination of its Exclusive License Agreement with the Company (the “License Agreement”) due to strategic and business reasons. The termination of the License Agreement will be effective 90 days from April 20, 2017 in accordance with Section 10.2 of the License Agreement. There was no financial impact resulting from the termination of the License Agreement with Novo Nordisk A/S. On March 22, 2017, the Company received a notice from the Listing Qualifications Staff of The NASDAQ Stock Market LLC (the “Staff”) that the Company was not in compliance with the $50 million in total assets and total revenue standard for continued listing on the NASDAQ Global Market under NASDAQ’s Listing Rule 5450(b)(3)(A) and that the Company also did not comply with either of the two alternative standards of Listing Rule 5450(b), the equity standard and the market value standard. On May 2, 2017, the Staff informed the Company that, following ten consecutive business days where the market value of the Company’s listed securities were $50 million or greater, the Company was in compliance with the NASDAQ Listing Rule 5450(b)(2)(A) and will continue to be listed on the NASDAQ Global Market. |
Basis of Presentation and Sig19
Basis of Presentation and Significant Accounting Policies (Policies) | 3 Months Ended |
Mar. 31, 2017 | |
Accounting Policies [Abstract] | |
Basis of Presentation | Basis of Presentation The condensed consolidated financial statements include the accounts of the Company and its wholly owned subsidiaries. All intercompany accounts and transactions among consolidated entities were eliminated upon consolidation. The unaudited consolidated financial statements were prepared in accordance with generally accepted accounting principles (“GAAP”) in the United States for interim financial information and with the instructions to Form 10-Q and Article 10 of Regulation S-X. As permitted under those rules certain footnotes or other financial information can be condensed or omitted. These financial statements and related disclosures have been prepared with the assumption that users of the interim financial information have read or have access to the audited consolidated financial statements for the preceding fiscal year. Accordingly, these statements should be read in conjunction with the audited consolidated financial statements and related notes included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016, filed with the U.S. Securities and Exchange Commission (“SEC”) on March 16, 2017. These financial statements have been prepared on the same basis as the Company’s annual consolidated financial statements and, in the opinion of management, reflect all adjustments, consisting only of normal recurring adjustments that are necessary for a fair statement of the Company’s consolidated financial information. The interim results of operations are not necessarily indicative of the results that may be expected for the full year. |
Use of Estimates | Use of Estimates The preparation of financial statements in conformity with GAAP in the United States requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, revenue and expenses, and related disclosures. On an ongoing basis, management evaluates its estimates including, but not limited to, those related to revenue recognition, debt amendments, research and development expense, long-lived assets, restructuring liabilities, legal contingencies, and stock-based compensation. The Company bases its estimates on historical experience and on various other market-specific and other relevant assumptions that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ significantly from these estimates, such as the Company’s billing under government contracts and the Company’s accrual for clinical trial expenses. Under the Company’s contracts with the National Institute of Allergy and Infectious Diseases (“NIAID”), a part of the National Institutes of Health (“NIH”), the Company bills using NIH provisional rates and thus is subject to future audits at the discretion of NIAID’s contracting office. These audits can result in an adjustment to revenue previously reported which potentially could be significant. In March 2016, the Company effected the novation of its remaining active contract with NIAID to Nanotherapeutics, Inc. (“Nanotherapeutics”) (see Note 6). The billings made prior to the effective date of the novation of such contract are still subject to future audits, which may result in significant adjustments to reported revenues. The Company’s accrual for clinical trials is based on estimates of the services received and efforts expended under contracts with clinical trial centers and clinical research organizations. |
Revenue Recognition | Revenue Recognition Revenue is recognized when the four basic criteria of revenue recognition are met: (1) persuasive evidence of an arrangement exists; (2) delivery has occurred or services have been rendered; (3) the fee is fixed or determinable; and (4) collectability is reasonably assured. The determination of criteria (2) is based on management’s judgments regarding whether a continuing performance obligation exists. The determination of criteria (3) and (4) are based on management’s judgments regarding the nature of the fee charged for products or services delivered and the collectability of those fees. Allowances are established for estimated uncollectible amounts, if any. The Company recognizes revenue from its license and collaboration arrangements, contract services, and royalties. Revenue arrangements with multiple elements are divided into separate units of accounting if certain criteria are met, including whether the delivered element has stand-alone value to the customer and whether there is objective and reliable evidence of the fair value of the undelivered items. Each deliverable in the arrangement is evaluated to determine whether it meets the criteria to be accounted for as a separate unit of accounting or whether it should be combined with other deliverables. In order to account for the multiple-element arrangements, the Company identifies the deliverables included within the arrangement and evaluates which deliverables represent separate units of accounting. Analyzing the arrangement to identify deliverables requires the use of judgment, and each deliverable may be an obligation to deliver services, a right or license to use an asset, or another performance obligation. The consideration received is allocated among the separate units of accounting based on their respective fair values and the applicable revenue recognition criteria are applied to each of the separate units. Advance payments received in excess of amounts earned are classified as deferred revenue until earned. License and Collaborative Fees Revenue from non-refundable license, technology access or other payments under license and collaborative agreements where the Company has a continuing obligation to perform is recognized as revenue over the estimated period of the continuing performance obligation. The Company estimates the performance period at the inception of the arrangement and reevaluates it each reporting period. Management makes its best estimate of the period over which it expects to fulfill the performance obligations, which may include clinical development activities. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the performance period. This reevaluation may shorten or lengthen the period over which the remaining revenue is recognized. Changes to these estimates are recorded on a prospective basis. License and collaboration agreements with certain third parties also provide for contingent payments to be paid to the Company based solely upon the performance of the partner. For such contingent payments, revenue is recognized upon completion of the milestone event, once confirmation is received from the third party, provided that collection is reasonably assured and the other revenue recognition criteria have been satisfied. Milestone payments that are not substantive or that require a continuing performance obligation on the part of the Company are recognized over the expected period of the continuing performance obligation. Amounts received in advance are recorded as deferred revenue until the related milestone is completed. Payment related to an option to purchase the Company’s commercialization rights is considered substantive if, at the inception of the arrangement, the Company is at risk as to whether the collaboration partner will choose to exercise the option. Factors that the Company considers in evaluating whether an option is substantive include the overall objective of the arrangement, the benefit the collaborator might obtain from the arrangement without exercising the option, the cost to exercise the option and the likelihood that the option will be exercised. For arrangements under which an option is considered substantive, the Company does not consider the item underlying the option to be a deliverable at the inception of the arrangement and the associated option fees are not included in allocable arrangement consideration, assuming the option is not priced at a significant and incremental discount. Conversely, for arrangements under which an option is not considered substantive or if an option is priced at a significant and incremental discount, the Company would consider the item underlying the option to be a deliverable at the inception of the arrangement and a corresponding amount would be included in allocable arrangement consideration. Contract and Other Revenues Contract revenue for research and development involves the Company providing research and development services to collaborative parties or others. Cost reimbursement revenue under collaborative agreements is recorded as contract and other revenues and is recognized as the related research and development costs are incurred, as provided for under the terms of these agreements. Revenue for certain contracts is accounted for by a proportional performance, or output-based, method where performance is based on estimated progress toward elements defined in the contract. The amount of contract revenue and related costs recognized in each accounting period are based on management’s estimates of the proportional performance during the period. Adjustments to estimates based on actual performance are recognized on a prospective basis and do not result in reversal of revenue should the estimate to complete be extended. Up-front fees associated with contract revenue are recorded as license and collaborative fees and are recognized in the same manner as the final deliverable, which is generally ratably over the period of the continuing performance obligation. Given the uncertainties of research and development collaborations, significant judgment is required to determine the duration of the arrangement. Royalty revenue and royalty receivables are recorded in the periods these royalty amounts are earned, if estimable and collectability is reasonably assured. The royalty revenue and receivables recorded in these instances are based upon communication with the Company’s licensees, historical information and forecasted sales trends. |
Sale of Future Revenue Streams | Sale of Future Revenue Streams The Company has sold its rights to receive certain milestones and royalties on product sales. In the circumstance where the Company has sold its rights to future milestones and royalties under a license agreement and also maintains limited continuing involvement in the arrangement (but not significant continuing involvement in the generation of the cash flows that are due to the purchaser), the Company defers recognition of the proceeds it receives for the sale of milestone or royalty stream and recognizes such deferred revenue as contract and other revenue over the life of the underlying license agreement. The Company recognizes this revenue under the "units-of-revenue" method. Under this method, amortization for a reporting period is calculated by computing a ratio of the proceeds received from the purchaser to the total payments expected to be made to the purchaser over the term of the agreement, and then applying that ratio to the period’s cash payment. Estimating the total payments expected to be received by the purchaser over the term of such arrangements requires management to use subjective estimates and assumptions. Changes to the Company’s estimate of the payments expected to be made to the purchaser over the term of such arrangements could have a material effect on the amount of revenues recognized in any particular period. |
Research and Development Expenses | Research and Development Expenses The Company expenses research and development costs as incurred. Research and development expenses consist of direct costs such as salaries and related personnel costs, and material and supply costs, and research-related allocated overhead costs, such as facilities costs. In addition, research and development expenses include costs related to clinical trials. From time to time, research and development expenses may include up-front fees and milestones paid to collaborative partners for the purchase of rights to in-process research and development. Such amounts are expensed as incurred. The Company’s accrual for clinical trials is based on estimates of the services received and efforts expended under contracts with clinical trial centers and clinical research organizations. The Company may terminate these contracts upon written notice and is generally only liable for actual effort expended by the organizations to the date of termination, although in certain instances the Company may be further responsible for termination fees and penalties. The Company makes estimates of its accrued expenses as of each balance sheet date based on the facts and circumstances known to the Company at that time. Expenses resulting from clinical trials are recorded when incurred, based in part on estimates as to the status of the various trials. |
Stock-Based Compensation | Stock-Based Compensation The Company recognizes compensation expense for all stock-based payment awards made to the Company’s employees, consultants and directors that are expected to vest based on estimated fair values. The valuation of stock option awards is determined at the date of grant using the Black-Scholes Option Pricing Model (the “Black-Scholes Model”). The Black-Scholes Model requires inputs such as the expected term of the option, expected volatility and risk-free interest rate. To establish an estimate of expected term, the Company considers the vesting period and contractual period of the award and its historical experience of stock option exercises, post-vesting cancellations and volatility. The estimate of expected volatility is based on the Company’s historical volatility. The risk-free rate is based on the yield available on United States Treasury zero-coupon issues corresponding to the expected term of the award. The valuation of restricted stock units (“RSUs”) is determined at the date of grant using the Company’s closing stock price. In January 2017, the Company adopted Accounting Standards Update (“ASU”) No. 2016-09, Compensation—Stock Compensation (Topic 718): Improvements to Employee Share-Based Payment Accounting, |
Restructuring and Impairment Charges | Restructuring and Impairment Charges Restructuring costs are primarily comprised of severance costs related to workforce reductions, contract termination costs and asset impairments. The Company recognizes restructuring charges when the liability has been incurred, except for employee termination benefits that are incurred over time. Generally, employee termination benefits (i.e., severance costs) are accrued at the date management has committed to a plan of termination and employees have been notified of their termination dates and expected severance payments. Key assumptions in determining the restructuring costs include the terms and payments that may be negotiated to terminate certain contractual obligations and the timing of employees leaving the Company. Other costs, including contract termination costs, are recorded when the arrangement is terminated. Asset impairment charges have been, and will be, recognized when management has concluded that the assets have been impaired. |
Warrants | Warrants The Company has issued warrants to purchase shares of its common stock in connection with financing activities. The Company accounted for some of these warrants as a liability at fair value and others as equity at fair value. The fair value of the outstanding warrants was estimated using the Black-Scholes Model. The Black-Scholes Model required inputs such as the expected term of the warrants, expected volatility and risk-free interest rate. These inputs were subjective and required significant analysis and judgment to develop. For the estimate of the expected term, the Company used the full remaining contractual term of the warrant. The Company determined the expected volatility assumption in the Black-Scholes Model based on historical stock price volatility observed on the Company’s underlying stock. The assumptions associated with contingent warrant liabilities were reviewed each reporting period and changes in the estimated fair value of these contingent warrant liabilities were recognized in revaluation of contingent warrant liabilities within the consolidated statements of comprehensive loss. |
Net Loss per Share Available to Common Stockholders | Net Loss per Share Available to Common Stockholders Basic net loss per share available to common stockholders is based on the weighted average number of shares of common stock outstanding during the period. Net loss available to common stockholders consists of net loss, as adjusted for the convertible preferred stock deemed dividends related to the beneficial conversion feature on this instrument at issuance. Diluted net loss per share available to common stockholders is based on the weighted average number of shares outstanding during the period, adjusted to include the assumed conversion of preferred stock, certain stock options, RSUs, and warrants for common stock. The calculation of diluted loss per share available to common stockholders requires that, to the extent the average market price of the underlying shares for the reporting period exceeds the exercise price of the warrants and the presumed exercise of such securities are dilutive to earnings (loss) per share available to common stockholders for the period, adjustments to net loss used in the calculation are required to remove the change in fair value of the warrants for the period. Likewise, adjustments to the denominator are required to reflect the related dilutive shares. |
Concentration of Risk | Concentration of Risk Cash equivalents and receivables are financial instruments, which potentially subject the Company to concentrations of credit risk, as well as liquidity risk for certain cash equivalents, such as money market funds. The Company has not encountered any such liquidity issues during 2017. The Company has not experienced any significant credit losses and does not generally require collateral on receivables. For the three months ended March 31, 2017, two customers represented 58% and 42% of total revenues. For the three months ended March 31, 2016, three customers represented 38%, 27%, and 23% of total revenues. As of March 31, 2017, two customers represented 81% and 14% |
Recent Accounting Pronouncements | Recent Accounting Pronouncements In May 2014, the Financial Accounting Standards Board (“FASB”) issued guidance codified in Accounting Standards Codification (“ASC”) 606, Revenue Recognition — Revenue from Contracts with Customers Revenue Recognition In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842) |
Fair Value Measurements | The Company records its financial assets and liabilities at fair value. The carrying amounts of certain of the Company’s financial instruments, including cash and cash equivalents, trade receivables and accounts payable, approximate their fair value due to their short maturities. Fair value is defined as the exchange price that would be received from selling an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. The accounting guidance for fair value establishes a framework for measuring fair value and a fair value hierarchy that prioritizes the inputs used in valuation techniques. The accounting standard describes a fair value hierarchy based on three levels of inputs, of which the first two are considered observable and the last unobservable, that may be used to measure fair value, which are the following: Level 1 – Observable inputs, such as quoted prices in active markets for identical assets or liabilities. Level 2 – Observable inputs, either directly or indirectly, other than quoted prices in active markets for identical assets or liabilities, such as quoted prices in active markets for similar assets or liabilities, quoted prices in markets that are not active or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Level 3 – Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities; therefore, requiring an entity to develop its own valuation techniques and assumptions. |
Condensed Consolidated Financ20
Condensed Consolidated Financial Statements Detail (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Condensed Consolidated Financial Statements Detail [Abstract] | |
Property and Equipment, Net | Property and equipment, net consisted of the following (in thousands): March 31, December 31, 2017 2016 Equipment and furniture $ 2,691 $ 14,023 Leasehold improvements 554 554 3,245 14,577 Less: Accumulated depreciation and amortization (2,849 ) (13,541 ) Property and equipment, net $ 396 $ 1,036 |
Accrued and Other Liabilities | Accrued and other liabilities consisted of the following (in thousands): March 31, December 31, 2017 2016 Accrued payroll and other benefits $ 123 $ 1,582 Accrued clinical trial costs 394 743 Accrued incentive compensation 203 — Accrued legal and accounting fees 670 385 Other 783 1,505 Total $ 2,173 $ 4,215 |
Reconciliation of the Numerator (Net Loss) and the Denominator (Number of Shares) Used in the Calculation of Basic and Diluted Net Loss Per Share Available to Common Stockholders | The following is a reconciliation of the numerator (net loss) and the denominator (number of shares) used in the calculation of basic and diluted net loss per share available to common stockholders (in thousands): Three Months Ended March 31, 2017 2016 Numerator Net loss $ (10,715 ) $ (8,365 ) Deemed dividend on convertible preferred stock (5,603 ) — Net loss available to common stockholders, basic and diluted $ (16,318 ) $ (8,365 ) Denominator Weighted average shares outstanding used for basic and diluted net loss per share available to common stockholders 6,887 5,978 |
Outstanding Securities Considered Anti-Dilutive | Potentially dilutive securities are excluded from the calculation of diluted net loss per share available to common stockholders if their inclusion is anti-dilutive. The following table shows the weighted-average outstanding securities considered anti-dilutive and therefore excluded from the computation of diluted net loss per share available to common stockholders (in thousands): Three Months Ended March 31, 2017 2016 Convertible preferred stock (as converted) 2,446 — Common stock options and RSUs 653 535 Warrants for common stock 381 911 Total 3,480 1,446 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Fair Value Disclosures [Abstract] | |
Financial Assets and Liabilities Carried at Fair Value on Recurring Basis | The following tables set forth the Company’s fair value hierarchy for its financial assets and liabilities measured at fair value on a recurring basis as follows (in thousands): Fair Value Measurements at March 31, 2017 Using Quoted Prices in Active Markets for Identical Assets Significant Other Observable Inputs Significant Unobservable Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds (1) $ 17,175 $ — $ — $ 17,175 Fair Value Measurements at December 31, 2016 Using Quoted Prices in Active Markets for Identical Assets Significant Other Observable Inputs Significant Unobservable Inputs (Level 1) (Level 2) (Level 3) Total Assets: Money market funds (1) $ 4,161 $ — $ — $ 4,161 (1) Included in cash and cash equivalents |
Outstanding Debt Carrying Amount and Estimated Fair Value | The carrying amount and the estimated fair value of the Company’s outstanding interest-bearing obligations at March 31, 2017, and December 31, 2016, are as follows (in thousands): March 31, 2017 December 31, 2016 Carrying Amount Estimated Fair Value Carrying Amount Estimated Fair Value Hercules term loan $ — $ — $ 16,850 $ 16,453 Novartis note 14,085 13,892 14,086 13,836 Servier loan 12,544 12,541 12,231 12,242 Total $ 26,629 $ 26,433 $ 43,167 $ 42,531 |
Restructuring Charges (Tables)
Restructuring Charges (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Restructuring And Related Activities [Abstract] | |
Components of Accrued Restructuring Costs | The following table summarizes the accrued restructuring costs on the condensed consolidated balance sheet as of March 31, 2017 (in thousands): Employee Severance and Other Benefits Balance at December 31, 2016 $ 3,594 Restructuring charges 2,020 Cash payments (3,821 ) Balance at March 31, 2017 $ 1,793 |
Long-Term Debt (Tables)
Long-Term Debt (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Debt Disclosure [Abstract] | |
Aggregate Future Principal and Discounts of Interest Bearing Obligations | Payments of Interest Bearing Obligations Aggregate future principal and discounts of the Company’s total interest bearing obligations as of March 31, 2017, are as follows (in thousands): Nine months ending December 31, 2017 $ 5,454 Year ending December 31, 2018 7,545 Year ending December 31, 2019 — Year ending December 31, 2020 15,980 28,979 Less: interest, discount and issuance cost (2,350 ) 26,629 Less: interest bearing obligations – current (12,544 ) Interest bearing obligations – non-current $ 14,085 |
Interest Expense and Amortization of Debt Issuance Costs | Amortization of debt issuance costs and discounts are included in interest expense. Interest expense in the condensed consolidated statements of comprehensive loss relates to the following debt instruments (in thousands ) Three Months Ended March 31, 2017 2016 Hercules term loan $ 311 $ 672 Servier loan 177 226 Novartis note 117 97 Other 4 7 Total interest expense $ 609 $ 1,002 |
Common Stock Warrants (Tables)
Common Stock Warrants (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Warrants And Rights Note Disclosure [Abstract] | |
Summary of Common Stock Warrants Outstanding | As of March 31, 2017 and December 31, 2016, the following common stock warrants were outstanding: Issuance Date Expiration Date Balance Sheet Classification Exercise Price per Share March 31, 2017 December 31, 2016 March 2012 March 2017 Contingent warrant liability $ 35.20 — 479,277 September 2012 September 2017 Stockholders' deficit $ 70.80 1,967 1,967 February 2015 February 2020 Stockholders' deficit $ 66.20 9,063 9,063 February 2016 February 2021 Stockholders' deficit $ 15.40 8,249 8,249 19,279 498,556 |
Stock-based Compensation (Table
Stock-based Compensation (Tables) | 3 Months Ended |
Mar. 31, 2017 | |
Disclosure Of Compensation Related Costs Sharebased Payments [Abstract] | |
Weighted Average Assumptions | The fair value of the stock options granted during the three months ended March 31, 2017 and 2016, was estimated based on the following weighted average assumptions: Three Months Ended March 31, 2017 2016 Dividend yield 0 % 0 % Expected volatility 100 % 106 % Risk-free interest rate 1.95 % 1.27 % Expected term 5.6 years 5.6 years |
Stock Option Activity | Stock option activity for the three months ended March 31, 2017, was as follows: Options Weighted Average Weighted Average Remaining Contractual Life (in years) Aggregate Intrinsic Value (in thousands) Outstanding at January 1, 2017 568,292 $ 77.70 Granted 15,222 4.67 Forfeited, expired or cancelled (23,813 ) 140.84 Outstanding at March 31, 2017 559,701 $ 73.03 6.92 $ 363 Exercisable at March 31, 2017 317,119 $ 119.38 4.99 $ 3 |
RSU Activity | RSU activity for the three months ended March 31, 2017, is summarized below: Weighted- Number of Average Grant- Shares Date Fair Value Unvested at January 1, 2017 91,228 $ 39.82 Granted 11,799 $ 4.67 Vested (53,300 ) $ 37.88 Forfeited (15,040 ) $ 42.49 Unvested at March 31, 2017 34,687 $ 29.69 |
Stock-based Compensation Expense | The following table shows total stock-based compensation expense for stock options, RSUs and ESPP in the condensed consolidated statements of comprehensive loss (in thousands): Three Months Ended March 31, 2017 2016 Research and development $ 441 $ 1,137 General and administrative 559 1,169 Total stock-based compensation expense $ 1,000 $ 2,306 |
Description of Business - Addit
Description of Business - Additional Information (Details) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | ||||
Oct. 31, 2016$ / shares | Mar. 31, 2017USD ($)$ / shares | Dec. 31, 2016USD ($)$ / shares | Mar. 31, 2016USD ($) | Dec. 31, 2015USD ($) | ||
Description Of Business [Abstract] | ||||||
Accumulated deficit | $ 1,204,370 | $ 1,193,613 | [1] | |||
Working capital deficiency | 600 | |||||
Carrying value of the loan | 26,629 | |||||
Cash and cash equivalents | $ 20,045 | $ 25,742 | [1] | $ 46,153 | $ 65,767 | |
Reverse stock split, description | In October 2016, the Company’s stockholders voted at a special meeting of stock holders to approve a series of alternate amendments to the Company’s Amended Certificate of Incorporation to effect a reverse stock split of the Company’s issued and outstanding common stock. The Company’s Board of Directors then approved a specific ratio of 1-for-20. | |||||
Reverse stock split ratio | 0.05 | |||||
Common stock, par value per share | $ / shares | $ 0.0075 | $ 0.0075 | $ 0.0075 | |||
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Basis of Presentation and Sig27
Basis of Presentation and Significant Accounting Policies - Additional Information (Details) - Customer Concentration Risk [Member] - Customer | 3 Months Ended | 12 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | Dec. 31, 2016 | |
Revenues [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Number of major customers | 2 | 3 | |
Revenues [Member] | Customer 1 [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Concentration risk, percentage (in hundredths) | 58.00% | 38.00% | |
Revenues [Member] | Customer 2 [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Concentration risk, percentage (in hundredths) | 42.00% | 27.00% | |
Revenues [Member] | Customer 3 [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Concentration risk, percentage (in hundredths) | 23.00% | ||
Accounts Receivable [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Number of major customers | 2 | 1 | |
Accounts Receivable [Member] | Customer 1 [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Concentration risk, percentage (in hundredths) | 81.00% | 85.00% | |
Accounts Receivable [Member] | Customer 2 [Member] | |||
Basis Of Presentation And Significant Accounting Policies [Line Items] | |||
Concentration risk, percentage (in hundredths) | 14.00% |
Condensed Consolidated Financ28
Condensed Consolidated Financial Statements Detail - Additional Information 1 (Details) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | |
Cash and Cash Equivalents [Line Items] | |||||
Cash and cash equivalents | $ 20,045 | $ 25,742 | [1] | $ 46,153 | $ 65,767 |
Demand Deposits [Member] | |||||
Cash and Cash Equivalents [Line Items] | |||||
Cash and cash equivalents | 2,900 | 21,500 | |||
Money Market Funds [Member] | |||||
Cash and Cash Equivalents [Line Items] | |||||
Cash and cash equivalents | $ 17,200 | $ 4,200 | |||
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Condensed Consolidated Financ29
Condensed Consolidated Financial Statements Detail - Property and Equipment, Net (Details) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | |
Property, Plant and Equipment [Line Items] | |||
Property and equipment, gross | $ 3,245 | $ 14,577 | |
Less: Accumulated depreciation and amortization | (2,849) | (13,541) | |
Property and equipment, net | 396 | 1,036 | [1] |
Equipment and Furniture [Member] | |||
Property, Plant and Equipment [Line Items] | |||
Property and equipment, gross | 2,691 | 14,023 | |
Leasehold Improvements [Member] | |||
Property, Plant and Equipment [Line Items] | |||
Property and equipment, gross | $ 554 | $ 554 | |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Condensed Consolidated Financ30
Condensed Consolidated Financial Statements Detail - Additional Information 2 (Details) $ in Millions | 3 Months Ended |
Mar. 31, 2017USD ($) | |
Property, Plant and Equipment [Line Items] | |
Total proceeds from sale of equipment | $ 1.6 |
Carrying value of equipment sold | 0.3 |
Other receivables related to sale of property and equipment | 0.8 |
Other Income (Expense) [Member] | |
Property, Plant and Equipment [Line Items] | |
Gain on sale of equipment | $ 1.3 |
Condensed Consolidated Financ31
Condensed Consolidated Financial Statements Detail - Accrued and Other Liabilities (Details) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | |
Accrued and other liabilities [Abstract] | |||
Accrued payroll and other benefits | $ 123 | $ 1,582 | |
Accrued clinical trial costs | 394 | 743 | |
Accrued incentive compensation | 203 | ||
Accrued legal and accounting fees | 670 | 385 | |
Other | 783 | 1,505 | |
Total | $ 2,173 | $ 4,215 | [1] |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Condensed Consolidated Financ32
Condensed Consolidated Financial Statements Detail - Reconciliation of the Numerator (Net Loss) and the Denominator (Number of Shares) Used in the Calculation of Basic and Diluted Net Loss Per Share Available to Common Stockholders (Details) - USD ($) shares in Thousands, $ in Thousands | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Numerator | ||
Net loss | $ (10,715) | $ (8,365) |
Deemed dividend on convertible preferred stock | (5,603) | |
Net loss available to common stockholders, basic and diluted | $ (16,318) | $ (8,365) |
Denominator | ||
Weighted average shares outstanding used for basic and diluted net loss per share available to common stockholders | 6,887 | 5,978 |
Condensed Consolidated Financ33
Condensed Consolidated Financial Statements Detail - Outstanding Securities Considered Anti-Dilutive (Details) - shares shares in Thousands | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share (in shares) | 3,480 | 1,446 |
Convertible Preferred Stock (as Converted) [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share (in shares) | 2,446 | |
Common Stock Options and RSUs [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share (in shares) | 653 | 535 |
Warrants for Common Stock [Member] | ||
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items] | ||
Antidilutive securities excluded from computation of earnings per share (in shares) | 381 | 911 |
Collaborative, Licensing and 34
Collaborative, Licensing and Other Arrangements - Servier - Additional Information (Details) - Collaborative Arrangement [Member] - Servier [Member] - USD ($) | 3 Months Ended | 6 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | Mar. 25, 2016 | |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | |||
Future initial research and development expenses to be funded by counterparty | $ 50,000,000 | ||
Contract and other revenue | $ 0 | $ 300,000 | |
Deferred revenue recognized | $ 600,000 |
Collaborative, Licensing and 35
Collaborative, Licensing and Other Arrangements - NIAID - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | |
Oct. 31, 2011 | Mar. 31, 2017 | Mar. 31, 2016 | |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | |||
Recognition of revenue | $ 110,000 | $ 1,471,000 | |
National Institute of Allergy and Infectious Diseases "NIAID" [Member] | Arrangement with Governmental Agency 1 [Member] | |||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | |||
Total contract amount awarded | $ 28,000,000 | ||
Contractual term | 5 years | ||
Recognition of revenue | $ 0 | $ 1,100,000 |
Collaborative, Licensing and 36
Collaborative, Licensing and Other Arrangements - Sale of Future Revenue Streams - Additional Information (Details) $ in Thousands | Dec. 21, 2016USD ($) | Mar. 31, 2017USD ($)Agreement | Dec. 31, 2016USD ($) | |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||
Deferred revenue – current | $ 1,381 | $ 899 | [1] | |
Deferred revenue, non-current | $ 17,408 | 18,000 | [1] | |
HCRP [Member] | ||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||
Number of royalty Interest acquisition agreements | Agreement | 2 | |||
Deferred revenue | $ 18,000 | |||
Contract and other revenue | 100 | |||
Deferred revenue – current | 500 | |||
Deferred revenue, non-current | $ 17,400 | $ 18,000 | ||
HCRP [Member] | First Acquisition Agreement [Member] | ||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||
Upfront cash payment received | $ 6,500 | |||
Eligible potential additional payments receivable upon achievement of specified net sales milestones in 2017, 2018 and 2019 | 4,000 | |||
HCRP [Member] | Second Acquisition Agreement [Member] | ||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||
Upfront cash payment received | $ 11,500 | |||
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Fair Value Measurements - Finan
Fair Value Measurements - Financial Assets and Liabilities Carried at Fair Value on Recurring Basis (Details) - Recurring [Member] - Money Market Funds [Member] - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | |
Assets: | |||
Money market funds | [1] | $ 17,175 | $ 4,161 |
Quoted Prices in Active Markets for Identical Assets (Level 1) [Member] | |||
Assets: | |||
Money market funds | [1] | $ 17,175 | $ 4,161 |
[1] | Included in cash and cash equivalents |
Fair Value Measurements - Outst
Fair Value Measurements - Outstanding Debt Carrying Amount and Estimated Fair Value (Details) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 |
Carrying Amount [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | $ 26,629 | $ 43,167 |
Carrying Amount [Member] | Hercules Term Loan [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 16,850 | |
Carrying Amount [Member] | Novartis Note [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 14,085 | 14,086 |
Carrying Amount [Member] | Servier Loan [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 12,544 | 12,231 |
Estimated Fair Value [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 26,433 | 42,531 |
Estimated Fair Value [Member] | Hercules Term Loan [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 16,453 | |
Estimated Fair Value [Member] | Novartis Note [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | 13,892 | 13,836 |
Estimated Fair Value [Member] | Servier Loan [Member] | ||
Fair Value, Balance Sheet Grouping, Financial Statement Captions [Line Items] | ||
Interest-bearing obligations | $ 12,541 | $ 12,242 |
Disposition - Additional Inform
Disposition - Additional Information (Details) - USD ($) | Nov. 04, 2015 | Mar. 31, 2017 | Feb. 28, 2017 |
Asset Purchase Agreement and Nanotherapeutics License Agreement [Member] | |||
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items] | |||
Cash payments from Nanotherapeutics | $ 4,500,000 | ||
Number of shares removed from obligation to issue of common stock | 23,008 | ||
Contingent upon achieving certain specified future operating objectives | $ 3,000,000 | ||
Amount entitled to receive | $ 1,600,000 | ||
Amount received from sale of discontinued operation | 150,000 | ||
Remaining amount receivable in quarterly installments | $ 1,500,000 | ||
Biodefense Business [Member] | |||
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items] | |||
Sales of business, number of common stock shares eligible to receive | 23,008 | ||
Royalties receivable percentage on net sales | 15.00% | ||
Biodefense Business [Member] | Maximum [Member] | |||
Income Statement Balance Sheet And Additional Disclosures By Disposal Groups Including Discontinued Operations [Line Items] | |||
Cash payments from Nanotherapeutics | $ 4,500,000 |
Restructuring Charges - Additio
Restructuring Charges - Additional Information (Details) $ in Thousands | Dec. 19, 2016Employee | Mar. 31, 2017USD ($) | Mar. 31, 2016USD ($) | Jun. 30, 2017USD ($)Employee | Mar. 31, 2018USD ($) | Dec. 31, 2016USD ($) | [1] |
Restructuring Cost And Reserve [Line Items] | |||||||
Restructuring charges | $ 2,020 | $ 36 | |||||
Accrued restructuring expenses | 1,793 | $ 3,594 | |||||
2016 Restructuring [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Number of employees terminated | Employee | 57 | ||||||
2016 Restructuring [Member] | Severance, Other Termination Benefits and Outplacement Services [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Restructuring charges | 1,500 | ||||||
2017 Restructuring [Member] | Severance, Other Termination Benefits and Outplacement Services [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Restructuring charges | 500 | ||||||
2017 Restructuring [Member] | Forecast [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Number of additional employees expects to eliminate | Employee | 5 | ||||||
2017 and 2016 Restructuring [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Payments for restructuring expenses | 3,800 | ||||||
Accrued restructuring expenses | $ 1,800 | ||||||
2017 and 2016 Restructuring [Member] | Forecast [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Expected remaining future payments for restructuring | $ 1,000 | ||||||
2017 and 2016 Restructuring [Member] | Forecast [Member] | Executive Severance [Member] | |||||||
Restructuring Cost And Reserve [Line Items] | |||||||
Expected remaining future payments for restructuring | $ 800 | ||||||
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Restructuring Charges - Compone
Restructuring Charges - Components of Accrued Restructuring Costs (Details) $ in Thousands | 3 Months Ended | |
Mar. 31, 2017USD ($) | ||
Restructuring Cost And Reserve [Line Items] | ||
Balance at period start | $ 3,594 | [1] |
Balance at period end | 1,793 | |
Employee Severance and Other Benefits [Member] | ||
Restructuring Cost And Reserve [Line Items] | ||
Balance at period start | 3,594 | |
Restructuring charges | 2,020 | |
Cash payments | (3,821) | |
Balance at period end | $ 1,793 | |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Long-Term Debt - Novartis Note
Long-Term Debt - Novartis Note - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | |
May 31, 2005 | Mar. 31, 2017 | Dec. 31, 2016 | |
Novartis Note [Member] | |||
Debt Instrument [Line Items] | |||
Maturity date | Jun. 30, 2015 | ||
Research and development expenses funded through loan facility, maximum | 75.00% | ||
Maximum borrowing capacity under loan agreement | $ 50,000,000 | ||
Interest rate at period end | 3.32% | ||
Outstanding principal balance | $ 14,100,000 | $ 14,100,000 | |
Novartis Note [Member] | Six-month LIBOR [Member] | |||
Debt Instrument [Line Items] | |||
Basis spread on variable rate | 2.00% | ||
Secured Note Amendment [Member] | |||
Debt Instrument [Line Items] | |||
Maturity date | Sep. 30, 2020 | ||
Reduction in outstanding principal amount | $ 7,300,000 |
Long-Term Debt - Servier Loan A
Long-Term Debt - Servier Loan Agreement - Additional Information (Details) | Jan. 09, 2015USD ($)Tranche | Jan. 31, 2017USD ($) | Jan. 31, 2016EUR (€) | Jan. 31, 2011USD ($) | Mar. 31, 2017USD ($)€ / $ | Mar. 31, 2016USD ($) | Jul. 31, 2017 | Jan. 31, 2017USD ($) | Mar. 31, 2017EUR (€)€ / $ | Jan. 31, 2017EUR (€) | Dec. 31, 2016USD ($)€ / $ | Jan. 09, 2015EUR (€)Tranche |
Debt Instrument [Line Items] | ||||||||||||
Accrued interest paid | $ 396,000 | $ 646,000 | ||||||||||
Carrying value of the loan | $ 26,629,000 | |||||||||||
Servier Loan [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Date of agreement | Dec. 30, 2010 | |||||||||||
Maximum borrowing capacity under loan agreement | € | € 15,000,000 | |||||||||||
Proceeds from loan | $ 19,500,000 | |||||||||||
Date of loan amendment | Jan. 9, 2015 | |||||||||||
Date of agreement, after amendment | Aug. 12, 2013 | |||||||||||
Number of tranches | Tranche | 3 | 3 | ||||||||||
Principal payment amount | € | € 3,000,000 | |||||||||||
Accrued interest paid | € | € 200,000 | |||||||||||
Unamortized discount on debt | $ 1,900,000 | $ 8,900,000 | ||||||||||
Amortization of debt discount | $ 100,000 | 200,000 | ||||||||||
Carrying value of the loan | 12,544,000 | $ 12,231,000 | ||||||||||
Unrealized foreign exchange gains (loss) related to re-measurement of loan discount | 6,000 | 38,000 | ||||||||||
Outstanding principal balance | $ 12,800,000 | $ 12,600,000 | ||||||||||
Euro to US Dollar exchange rates | € / $ | 1.068 | 1.068 | 1.052 | |||||||||
Unrealized foreign exchange gains (loss) related to re-measurement of loan | $ (200,000) | $ (500,000) | ||||||||||
Servier Loan [Member] | Tranche One [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Maturity date | Jan. 15, 2016 | |||||||||||
Principal payment amount | € | € 3,000,000 | |||||||||||
Servier Loan [Member] | Tranche Two [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Maturity date | Jan. 15, 2017 | |||||||||||
Principal payment amount | € | 5,000,000 | |||||||||||
Servier Loan [Member] | Tranche Three [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Maturity date | Jan. 15, 2018 | |||||||||||
Principal payment amount | € | € 7,000,000 | |||||||||||
Servier Loan [Member] | Mid-July 2016 Through Mid-January 2017 [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Period of interest resetting | 6 months | |||||||||||
Interest rate during period | 1.81% | |||||||||||
Servier Loan [Member] | Amendment No.3 [Member] | Tranche Two [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Maturity date | Jul. 15, 2017 | |||||||||||
Principal payment amount | € | € 5,000,000 | |||||||||||
Unamortized discount on debt | $ 400,000 | $ 400,000 | ||||||||||
Servier Loan [Member] | Forecast [Member] | Mid-January 2017 Through Mid-July 2017 [Member] | ||||||||||||
Debt Instrument [Line Items] | ||||||||||||
Period of interest resetting | 6 months | |||||||||||
Interest rate during period | 1.77% |
Long-Term Debt - Hercules Term
Long-Term Debt - Hercules Term Loan - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | Feb. 27, 2015 | Mar. 31, 2017 | Mar. 31, 2016 | Dec. 31, 2016 |
Debt Instrument [Line Items] | ||||
Carrying value of the loan | $ 26,629 | |||
Loss on extinguishment of debt | $ (515) | |||
Warrants expiration period | 2017-03 | |||
Hercules Term Loan [Member] | ||||
Debt Instrument [Line Items] | ||||
Maturity date | Sep. 1, 2018 | |||
Variable rate basis | The Hercules Term Loan had a variable interest rate that was the greater of either (i) 9.40% plus the prime rate as reported from time to time in The Wall Street Journal minus 7.25%, or (ii) 9.40%. | |||
Period of principal and interest amortized | 30 months | |||
Amortization of interest payments period end date | Jun. 1, 2016 | |||
Period of interest | 1 month | |||
Additional interest rate in case of default | 5.00% | |||
Debt issuance costs | $ 500 | |||
Final payment fee | $ 1,200 | |||
Amortization of debt discount | $ 200 | $ 200 | ||
Outstanding principal balance | $ 17,500 | |||
Carrying value of the loan | $ 16,850 | |||
Prepayment charge not required to pay | 1.00% | |||
Loss on extinguishment of debt | $ 500 | |||
Aggregate number of unregistered shares of common stock called by warrants (in shares) | 9,063 | |||
Exercise price of warrants (in dollars per share) | $ 66.20 | |||
Estimated fair value of warrants | $ 500 | |||
Exercisable period of warrants | 5 years | |||
Warrants expiration period | 2020-02 | |||
Minimum [Member] | Hercules Term Loan [Member] | ||||
Debt Instrument [Line Items] | ||||
Percentage bearing variable rate | 9.40% | |||
Prime Rate [Member] | Hercules Term Loan [Member] | ||||
Debt Instrument [Line Items] | ||||
Basis spread, addition | 9.40% | |||
Basis spread, subtraction | 7.25% |
Long-Term Debt - Aggregate Futu
Long-Term Debt - Aggregate Future Principal and Discounts of Interest Bearing Obligations (Details) - USD ($) $ in Thousands | Mar. 31, 2017 | Dec. 31, 2016 | [1] |
Aggregate future principal and discounts of total interest bearing obligations - long-term [Abstract] | |||
Nine months ending December 31, 2017 | $ 5,454 | ||
Year ending December 31, 2018 | 7,545 | ||
Year ending December 31, 2020 | 15,980 | ||
Long-term debt including current portion, interest, final payment fee, discount and issuance cost | 28,979 | ||
Less: interest, discount and issuance cost | (2,350) | ||
Long-term debt including current portion | 26,629 | ||
Less: interest bearing obligations – current | (12,544) | $ (17,855) | |
Interest bearing obligations – non-current | $ 14,085 | $ 25,312 | |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited consolidated financial statements as of that date included in the Company’s Annual Report on Form 10-K for the year ended December 31, 2016. |
Long-Term Debt - Interest Expen
Long-Term Debt - Interest Expense and Amortization of Debt Issuance Costs (Details) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Interest expense and amortization of debt issuance costs [Abstract] | ||
Interest expense | $ 609 | $ 1,002 |
Hercules Term Loan [Member] | ||
Interest expense and amortization of debt issuance costs [Abstract] | ||
Interest expense | 311 | 672 |
Servier Loan [Member] | ||
Interest expense and amortization of debt issuance costs [Abstract] | ||
Interest expense | 177 | 226 |
Novartis Note [Member] | ||
Interest expense and amortization of debt issuance costs [Abstract] | ||
Interest expense | 117 | 97 |
Other [Member] | ||
Interest expense and amortization of debt issuance costs [Abstract] | ||
Interest expense | $ 4 | $ 7 |
Common Stock Warrants - Summary
Common Stock Warrants - Summary of Common Stock Warrants Outstanding (Details) - $ / shares | 3 Months Ended | |
Mar. 31, 2017 | Dec. 31, 2016 | |
Class Of Warrant Or Right [Line Items] | ||
Warrant outstanding (in shares) | 19,279 | 498,556 |
Five Year Warrants Issued in March 2012 [Member] | ||
Class Of Warrant Or Right [Line Items] | ||
Exercise price of warrants (in dollars per share) | $ 35.20 | |
Five Year Warrants Issued in March 2012 [Member] | Contingent Warrant Liability [Member] | ||
Class Of Warrant Or Right [Line Items] | ||
Issuance Date | 2012-03 | |
Expiration Date | 2017-03 | |
Exercise price of warrants (in dollars per share) | $ 35.20 | |
Warrant outstanding (in shares) | 479,277 | |
Five Year Warrants Issued in September 2012 [Member] | Stockholders' Deficit [Member] | ||
Class Of Warrant Or Right [Line Items] | ||
Issuance Date | 2012-09 | |
Expiration Date | 2017-09 | |
Exercise price of warrants (in dollars per share) | $ 70.80 | |
Warrant outstanding (in shares) | 1,967 | 1,967 |
Five Year Warrants Issued in February 2015 [Member] | Stockholders' Deficit [Member] | ||
Class Of Warrant Or Right [Line Items] | ||
Issuance Date | 2015-02 | |
Expiration Date | 2020-02 | |
Exercise price of warrants (in dollars per share) | $ 66.20 | |
Warrant outstanding (in shares) | 9,063 | 9,063 |
Five Year Warrants Issued in February 2016 [Member] | Stockholders' Deficit [Member] | ||
Class Of Warrant Or Right [Line Items] | ||
Issuance Date | 2016-02 | |
Expiration Date | 2021-02 | |
Exercise price of warrants (in dollars per share) | $ 15.40 | |
Warrant outstanding (in shares) | 8,249 | 8,249 |
Common Stock Warrants - Additio
Common Stock Warrants - Additional Information (Details) | 3 Months Ended |
Mar. 31, 2017$ / sharesshares | |
Class Of Warrant Or Right [Line Items] | |
Warrants expiration period | 2017-03 |
Five Year Warrants Issued in March 2012 [Member] | |
Class Of Warrant Or Right [Line Items] | |
Aggregate number of unregistered shares of common stock called by warrants (in shares) | shares | 741,729 |
Exercise price of warrants (in dollars per share) | $ / shares | $ 35.20 |
Legal Proceedings, Commitment49
Legal Proceedings, Commitments and Contingencies - Additional Information (Details) $ in Millions | Mar. 31, 2017USD ($) |
Commitments And Contingencies Disclosure [Abstract] | |
Estimate of milestone payments | $ 15.5 |
Stock-based Compensation - Addi
Stock-based Compensation - Additional Information (Details) - shares | 1 Months Ended | 3 Months Ended |
Feb. 28, 2017 | Mar. 31, 2017 | |
Stock Options [Member] | ||
Additional disclosures [Abstract] | ||
Minimum age required for employees to qualify for immediate vesting of RSUs | 55 years | |
Threshold years required for retirement age | 70 years | |
Number of stock options granted to members of board, executives, and non-executive employees | 15,222 | |
Restricted Stock Units (RSUs) [Member] | ||
Additional disclosures [Abstract] | ||
Minimum age required for employees to qualify for immediate vesting of RSUs | 55 years | |
Threshold years required for retirement age | 70 years | |
Non Executive Employee [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Vesting period | 4 years | |
Non Executive Employee [Member] | Restricted Stock Units (RSUs) [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Vesting period | 3 years | |
Directors [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Vesting period | 1 year | |
Directors [Member] | Restricted Stock Units (RSUs) [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Vesting period | 1 year | |
2015 ESPP [Member] | ||
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | ||
Percentage related to employees to purchase shares at the lower fair market value at offering period | 85.00% | |
2010 Plan [Member] | ||
Additional disclosures [Abstract] | ||
Number of stock options granted to members of board, executives, and non-executive employees | 1,018,000 |
Stock-based Compensation - Weig
Stock-based Compensation - Weighted Average Assumptions (Details) - Stock Options [Member] | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Stock-based awards weighted average assumptions [Abstract] | ||
Dividend yield | 0.00% | 0.00% |
Expected volatility | 100.00% | 106.00% |
Risk-free interest rate | 1.95% | 1.27% |
Expected term | 5 years 7 months 6 days | 5 years 7 months 6 days |
Stock-based Compensation - Stoc
Stock-based Compensation - Stock Option Activity (Details) - Stock Options [Member] $ / shares in Units, $ in Thousands | 3 Months Ended |
Mar. 31, 2017USD ($)$ / sharesshares | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |
Options, Outstanding at January 1, 2017 | shares | 568,292 |
Options, Granted | shares | 15,222 |
Options, Forfeited, expired or cancelled | shares | (23,813) |
Options, Outstanding at March 31, 2017 | shares | 559,701 |
Options, Exercisable at March 31, 2017 | shares | 317,119 |
Weighted Average Exercise Price Per Share, Outstanding at January 1, 2017 | $ / shares | $ 77.70 |
Weighted Average Exercise Price Per Share, Granted | $ / shares | 4.67 |
Weighted Average Exercise Price Per Share, Forfeited, expired or cancelled | $ / shares | 140.84 |
Weighted Average Exercise Price Per Share, Outstanding at March 31, 2017 | $ / shares | 73.03 |
Weighted Average Exercise Price Per Share, Exercisable at March 31, 2017 | $ / shares | $ 119.38 |
Weighted Average Remaining Contractual Life (in years), Outstanding at March 31, 2017 | 6 years 11 months 1 day |
Weighted Average Remaining Contractual Life (in years), Exercisable at March 31, 2017 | 4 years 11 months 27 days |
Aggregate Intrinsic Value, Outstanding at March 31, 2017 | $ | $ 363 |
Aggregate Intrinsic Value, Exercisable at March 31, 2017 | $ | $ 3 |
Stock-based Compensation - RSU
Stock-based Compensation - RSU Activity (Details) - Restricted Stock Units (RSUs) [Member] | 3 Months Ended |
Mar. 31, 2017$ / sharesshares | |
Share Based Compensation Arrangement By Share Based Payment Award [Line Items] | |
Number of Shares, Unvested at January 1, 2017 | shares | 91,228 |
Number of Shares, Granted | shares | 11,799 |
Number of Shares, Vested | shares | (53,300) |
Number of Shares, Forfeited | shares | (15,040) |
Number of Shares, Unvested at March 31, 2017 | shares | 34,687 |
Weighted Average Grant-Date Fair Value, Unvested at January 1, 2017 | $ / shares | $ 39.82 |
Weighted Average Grant-Date Fair Value, Granted | $ / shares | 4.67 |
Weighted Average Grant-Date Fair Value, Vested | $ / shares | 37.88 |
Weighted Average Grant-Date Fair Value, Forfeited | $ / shares | 42.49 |
Weighted Average Grant-Date Fair Value, Unvested at March 31, 2017 | $ / shares | $ 29.69 |
Stock-based Compensation - St54
Stock-based Compensation - Stock-based Compensation Expense (Details) - USD ($) $ in Thousands | 3 Months Ended | |
Mar. 31, 2017 | Mar. 31, 2016 | |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
Total stock-based compensation expense | $ 1,000 | $ 2,306 |
Research and Development [Member] | ||
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
Total stock-based compensation expense | 441 | 1,137 |
General and Administrative [Member] | ||
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ||
Total stock-based compensation expense | $ 559 | $ 1,169 |
Capital Stock - Biotechnology V
Capital Stock - Biotechnology Value Fund Financing - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 3 Months Ended | |
Feb. 28, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | |
Class Of Warrant Or Right [Line Items] | |||
Cash proceeds from issuance of common stock and convertible preferred stock | $ 24,900 | $ 25,452 | |
Preferred stock, stated value | $ 0.05 | $ 0.05 | |
Ownership percentage on outstanding shares | 19.80% | ||
Convertible Preferred Stock (as Converted) [Member] | |||
Class Of Warrant Or Right [Line Items] | |||
Sale of shares | 5,003 | ||
Preferred stock, stated value | $ 4,030 | ||
Conversion of preferred stock into registered common stock | 1,000 | ||
Preferred stock conversion price per share | $ 4.03 | ||
Total number of shares of common stock issued upon conversion | 5,003,000 | ||
Percentage of convertible preferred stock conversion blocker provision | 19.99% | ||
Convertible preferred stock voting rights description | Shares of Series X convertible preferred stock will generally have no voting rights, except as required by law and except that the consent of the holders of the outstanding Series X convertible preferred stock will be required to amend the terms of the Series X preferred stock and to approve certain corporate actions. | ||
Ownership percentage on outstanding shares upon conversion | 51.70% | ||
Fair value of common stock amount exceeded purchase price of convertible preferred stock | $ 5,600 | ||
Common Stock [Member] | |||
Class Of Warrant Or Right [Line Items] | |||
Sale of shares | 1,200,000 | ||
Common stock share price | $ 4.03 |
Capital Stock - ATM Agreements
Capital Stock - ATM Agreements - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | |
Feb. 28, 2017 | Mar. 31, 2017 | Nov. 12, 2015 | |
Common Stock [Member] | |||
Class Of Warrant Or Right [Line Items] | |||
Sale of shares | 1,200,000 | ||
2015 ATM Agreement [Member] | |||
Class Of Warrant Or Right [Line Items] | |||
Sales commission paid per transaction (in hundredths) | 3.00% | ||
Maximum amount of shares can be issued | $ 75,000,000 | ||
Proceeds from issuance of common stock | $ 600,000 | ||
Offering costs offset against proceeds upon sale of common stock | $ 200,000 | ||
2015 ATM Agreement [Member] | Common Stock [Member] | |||
Class Of Warrant Or Right [Line Items] | |||
Sale of shares | 110,252 |
Subsequent Events - Additional
Subsequent Events - Additional Information (Detail) - USD ($) | May 02, 2017 | Apr. 20, 2017 | Mar. 31, 2017 | Mar. 22, 2017 |
NASDAQ Stock Market LLC [Member] | ||||
Subsequent Event [Line Items] | ||||
Listing compliance description | the Company received a notice from the Listing Qualifications Staff of The NASDAQ Stock Market LLC (the “Staff”) that the Company was not in compliance with the $50 million in total assets and total revenue standard for continued listing on the NASDAQ Global Market under NASDAQ’s Listing Rule 5450(b)(3)(A) and that the Company also did not comply with either of the two alternative standards of Listing Rule 5450(b), the equity standard and the market value standard. | |||
Minimum stockholders equity and total revenue requirement for continued listing | $ 50,000,000 | |||
Subsequent Event [Member] | NASDAQ Stock Market LLC [Member] | ||||
Subsequent Event [Line Items] | ||||
Minimum required market value of listed securities | $ 50,000,000 | |||
Description of letter from listing qualifications staff | the Staff informed the Company that, following ten consecutive business days where the market value of the Company’s listed securities were $50 million or greater, the Company was in compliance with the NASDAQ Listing Rule 5450(b)(2)(A) and will continue to be listed on the NASDAQ Global Market. | |||
Number of consecutive business days | 10 days | |||
Novo Nordisk [Member] | ||||
Subsequent Event [Line Items] | ||||
Termination agreement, term description | The termination of the License Agreement will be effective 90 days from April 20, 2017 in accordance with Section 10.2 of the License Agreement. There was no financial impact resulting from the termination of the License Agreement with Novo Nordisk A/S. | |||
Novo Nordisk [Member] | Subsequent Event [Member] | ||||
Subsequent Event [Line Items] | ||||
Termination agreement, notice period | 90 days |