GAAP to Non-GAAP Financials for the Year Ended December 31, 2015 Twelve Months Ended Twelve Months Ended December 31, 2015 December 31, 2014 GAAP Adjustments Non - GAAP GAAP Adjustments Non - GAAP Revenues: Makena $ 251,615 $ — $ 251,615 $ 22,513 $ — $ 22,513 Feraheme/MuGard 90,201 — 90,201 87,485 — 87,485 Cord Blood Registry 24,132 19,136 17 43,268 — — — License fee, collaboration and other revenues 52,328 (39,965) 18 12,363 14,386 (8,217) 18 6,169 Total revenues 418,276 (20,829) 397,447 124,384 (8,217) 116,167 Operating costs and expenses: Cost of products sold 78,509 (64,5 36) 19 13,973 20,306 (6,706) 19 13,600 Cost of services 9,992 (1,563) 20 8,429 — — — Research and development 42,878 (14,258) 21 28,620 24,160 (1,662) 21 22,498 Selling, general and administr ative 160,309 (27,324) 22 132,985 72,254 (6,534) 22 65,720 Acquisition - related 11,232 (11,232) 23 — 9,478 (9,478) 23 — Restructuring 4,136 (4,136) 24 — 2,023 (2,023) 24 — Total costs a nd expenses 307,056 (123,049) 184,007 128,221 (26,403) 101,818 Operating income (loss) / adjusted EBITDA 111,220 102,220 213,440 (3,837) 18,186 14,349 Other income (expense): — Interes t expense (53,251) 12,041 25 (41,210) (14,697) 6,967 25 (7,730) Loss on debt extinguishment (10,449) 10,449 26 — — — — Interest and dividend income, net 1,512 — 1,512 975 (17) 958 O ther income, net (9,188) 9,185 26 (3) 217 (103) 114 Total other income (expense) (71,376) 31,675 (39,701) (13,505) 6,847 (6,658) Net income (loss) before income taxes 39,844 133,895 173,739 (17,342) 25,033 7,691 Income tax expense (benefit) 7,065 (7,065) 27 — (153,159) 153,159 27 — Net income (loss) / cash earnings $ 32,779 $ 140,960 $ 173,739 $ 135,817 $ (128,126) $ 7,691 Net income (loss) / ca sh earnings per share Basic $ 1.04 — $ 5.52 $ 6.06 — $ 0.34 Diluted $ 0.93 — $ 4.43 $ 5.45 — $ 0.30 Weighted average shares outstanding Basic 31,471 — 31,471 22,416 — 22,416 Diluted 35,308 — 39,211 25,225 — 25,225