Reconciliation of Non-GAAP Adjustments to Net Income for the 3- and 6- Months Ended June 30, 2016 and 2015 Three Months Ended Six Months Ended June 30, 2016 June 30, 2015 June 30, 2016 June 30, 2015 GAAP revenues $ 127,419 $ 123,884 $ 236,718 $ 213,389 Service revenues 5,053 4 — 13,614 4 — License fee, collaboration and other revenues — (33,563) 5 — (39,965) 5 Non-GAAP revenues 132,472 90,321 250,332 173,424 GAAP CBR revenues 24,379 — 43,898 — Service revenues 5,053 4 — 13,614 4 — Non-GAAP CBR revenues 29,432 — 57,512 — GAAP costs of product sales and services 27,132 19,679 50,957 40,705 Cost of product sales (17,627) 6 (16,521) 6 (32,236) 6 (34,261) 6 Cost of services (353) 7 — (713) 7 — Non-GAAP costs of product sales and services 9,152 3,158 18,008 6,444 GAAP costs and expenses 109,342 62,760 211,193 123,457 Cost of product sales (17,627) 6 (16,521) 6 (32,236) 6 (34,261) 5 Cost of services (353) 7 — (713) 7 — Research and development (1,867) 8 (1,197) 8 (2,641) 8 (1,691) 8 Selling., general and administrative (5,605) 9 (3,679) 9 (20,725) 9 (9,865) 9 Impairment charges of intangible assets (15,963) 10 — (15,963) 10 — Acquisition-related — (2,653) 11 — (2,653) 11 Restructuring (89) 12 (443) 12 (712) 12 (1,014) 12 Non-GAAP costs and expenses 67,838 38,267 138,203 73,973 GAAP other income (expense) (17,477) (9,831) (34,992) (20,127) Non-cash interest expense 3,104 13 2,944 13 6,162 13 5,830 13 Income tax expense (benefit) 1,196 14 17,655 14 (1,344) 14 23,025 14 Non-GAAP other income (expense) (13,177) 10,768 (30,174) 8,728 GAAP net income (loss) (596) 33,258 (8,123) 46,162 Total adjustments 50,857 11,529 91,422 38,374 Non-GAAP net income (loss) 50,261 44,787 83,299 84,536 27