Amag Pharmaceuticals (AMAG) 10-K 2015 FY Annual report

Exhibit 32.2

CERTIFICATION PURSUANT TO

18 U.S.C. SECTION 1350,

AS ADOPTED PURSUANT TO

SECTION 906 OF THE SARBANES‑OXLEY ACT OF 2002

In connection with the Annual Report of AMAG Pharmaceuticals, Inc. (the “Company”) on Form 10‑K for the year December 31, 2015 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I, Frank E. Thomas, President and Chief Operating Officer of the Company, certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes‑Oxley Act of 2002, that, to the best of my knowledge:

(1)The Report fully complies with the requirements of Section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Chief Accounting Officer, Treasurer and Senior Vice President, Finance and Investor Relations (principal financial officer)

/s/ Frank E. Thomas

Frank E. Thomas
President and Chief Operating Officer (principal financial officer)

Dated: February 24, 2016