Emisphere 424B3 Prospectus supplement

Filed Pursuant to Rule 424(b)(3) and Rule 424(c)
Registration No. 333-169385

PROSPECTUS SUPPLEMENT NO. 1

8,140,496 Shares of Common Stock

This Prospectus Supplement No. 1 (the “Prospectus Supplement”) amends our Prospectus dated October 13, 2010 (the “Prospectus”). The Prospectus relates to the offer for sale by the existing holders of our common stock, par value $0.01 per share, named in the Prospectus of 8,140,496 shares of our common stock, including 3,488,784 shares of our common stock issuable upon exercise of the warrants held by the selling security holders. These existing holders of our common stock are referred to as selling security holders throughout this Prospectus Supplement.

All of the shares of common stock offered by this Prospectus Supplement are being sold by the selling security holders. It is anticipated that the selling security holders will sell these shares of common stock from time to time in one or more transactions, in negotiated transactions or otherwise, at prevailing market prices or at prices otherwise negotiated. We will not receive any proceeds from the sales of shares of common stock by the selling security holders.

This Prospectus Supplement is being filed to include the information set forth in our Quarterly Report on Form 10-Q for our fiscal quarter ended September 30, 2010, filed with the Securities and Exchange Commission (“SEC”) on November 12, 2010, which is attached hereto. This Prospectus Supplement should be read in conjunction with the Prospectus.

Our common stock is currently traded on the Over-The-Counter Bulletin Board, commonly known as the OTC Bulletin Board (“OTCBB”), under the symbol “EMIS.” As of November 10, 2010, the closing sale price of our common stock was $1.77 per share.

Investing in our securities involves substantial risks. You should carefully consider the matters discussed under the section entitled “Risk Factors” beginning on page 7 of the Prospectus.

Neither the SEC nor any state securities commission has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.

The date of this prospectus supplement is November 12, 2010.

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM 10-Q

(Mark One)


þ		QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the quarterly period ended September 30, 2010


o		TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934

For the transition period from to

Commission File Number 000-17758

EMISPHERE TECHNOLOGIES, INC.

(Exact name of registrant as specified in its charter)


DELAWARE		13-3306985

(State or jurisdiction of incorporation or organization)		(I.R.S. Employer Identification Number)


240 Cedar Knolls Rd, Suite 200
Cedar Knolls, NJ		07927

(Address of principal executive offices)		(Zip Code)

(973) 532-8000
(Registrant’s telephone number, including area code)

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that Registrant was required to file such reports) and (2) has been subject to such filing requirements for the past 90 days. Yesþ Noo

Indicate by check mark whether the registrant has submitted electronically and posted on its corporate Web site, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files). Yeso Noo

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):


Large accelerated filero	Accelerated filero	Non-accelerated filero	Smaller reporting companyþ
		(Do not check if a smaller reporting company)

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act.) Yeso Noþ

The number of shares of the Registrant’s common stock, $.01 par value, outstanding as of November 1, 2010 was 51,889,102.

EMISPHERE TECHNOLOGIES, INC.

Index


PART I. FINANCIAL INFORMATION

Item 1. Financial Statements:			3
Condensed Balance Sheets as of September 30, 2010 (unaudited) and December 31, 2009			3
Condensed Statements of Operations for the three and nine months ended September 30, 2010 and 2009 (unaudited)			4
Condensed Statements of Cash Flows for the nine months ended September 30, 2010 and 2009 (unaudited)			5
Notes to Condensed Financial Statements (unaudited)			6
Item 2. Management’s Discussion and Analysis of Financial Condition and Results of Operations			20
Item 3. Quantitative and Qualitative Disclosures About Market Risk			31
Item 4T. Controls and Procedures			31

PART II. OTHER INFORMATION

Item 1. Legal Proceedings			32
Item 1A. Risk Factors			32
Item 2. Unregistered Sales of Equity Securities and Use of Proceeds			34
Item 6. Exhibits			35
SIGNATURES			37
EXHIBIT INDEX			38

All other items called for by the instructions to Form 10-Q have been omitted because the items are not applicable or the relevant information is not material.

PART I


ITEM 1. FINANCIAL STATEMENTS

EMISPHERE TECHNOLOGIES, INC.

CONDENSED BALANCE SHEETS
September 30, 2010 and December 31, 2009
(in thousands, except share and per share data)


	September 30, 2010			December 31, 2009
	(unaudited)
Assets:
Current assets:
Cash and cash equivalents	$	2,961		$	3,566
Accounts receivable, net		60			158
Inventories		260			20
Prepaid expenses and other current assets		539			369

Total current assets		3,820			4,113
Equipment and leasehold improvements, net		94			138
Purchased technology, net		897			1,077
Restricted cash		259			259
Deferred financing cost		273			346

Total assets	$	5,343		$	5,933

Liabilities and Stockholders’ Deficit:
Current liabilities:
Notes payable, including accrued interest and net of related discount	$	—		$	12,588
Accounts payable and accrued expenses		4,400			4,975
Derivative instruments
Related party		7,477			3,205
Others		2,423			2,984
Restructuring accrual, current		450			750
Contract termination liability		435			—
Other current liabilities		33			52

Total current liabilities		15,218			24,554
Notes payable, including accrued interest and net of related discount, related party		15,863			13,076
Deferred revenue		26,533			11,494
Derivative instrument related party		8,557			4,591
Deferred lease liability and other liabilities		56			82

Total liabilities		66,227			53,797
Commitments and Contingencies
Stockholders’ deficit:
Preferred stock, $.01 par value; authorized 1,000,000 shares; none issued and outstanding		—			—
Common stock, $.01 par value; authorized 100,000,000 shares; issued 52,178,834 shares (51,889,102 outstanding) as of September 30, 2010 and issued 42,360,133 shares (42,070,401 outstanding) as December 31, 2009		522			424
Additional paid-in-capital		401,740			392,335
Accumulated deficit		(459,194	)		(436,671	)
Common stock held in treasury, at cost; 289,732 shares		(3,952	)		(3,952	)

Total stockholders’ deficit		(60,884	)		(47,864	)

Total liabilities and stockholders’ deficit	$	5,343		$	5,933

The accompanying notes are an integral part of the financial statements.

EMISPHERE TECHNOLOGIES, INC.

CONDENSED STATEMENT OF OPERATIONS
For the three and nine months ended September 30, 2010 and 2009
(in thousands, except share and per share data)
(unaudited)


	For the three months ended						For the nine months ended
	September 30,						September 30,
	2010			2009			2010			2009

Net Sales	$	4		$	—		$	55		$	—

Costs and expenses:
Research and development		690			782			1,984			3,452
General and administrative expenses		2,516			2,493			6,979			8,348
Restructuring costs		—			—			50			(353	)
Gain on disposal of fixed assets		—			(2	)		(1	)		(824	)
Expense from settlement of lawsuit		58			—			278			—
Expense from termination of sales agreement		542			—			542			—
Depreciation and amortization		73			120			223			427

Total costs and expenses		3,879			3,393			10,055			11,050

Operating loss		(3,875	)		(3,393	)		(10,000	)		(11,050	)

Other non-operating income (expense):
Other income		2			24			7			91
Sublease income		—			—			—			232
Sale of patents		500			—			500			500
Change in fair value of derivative instruments
Related party		11,766			45			(3,562	)		(35	)
Other		2,831			576			(4,440	)		322
Interest expense
Related party		(1,573	)		(1,150	)		(4,642	)		(3,290	)
Other		(4	)		(139	)		(386	)		(411	)

Total other non-operating income (expense)		13,522			(644	)		(12,523	)		(2,591	)

Net income (loss)	$	9,647		$	(4,037	)	$	(22,523	)	$	(13,641	)

Net income (loss) per share, basic	$	0.20		$	(0.11	)	$	(0.51	)	$	(0.42	)

Net income (loss) per share, diluted	$	0.19		$	(0.11	)	$	(0.51	)	$	(0.42	)

Weighted average shares outstanding, basic		47,401,395			35,695,769			44,291,889			32,188,554

Weighted average shares outstanding, diluted		50,922,881			35,695,769			44,291,889			32,188,554

The accompanying notes are an integral part of the financial statements.

EMISPHERE TECHNOLOGIES, INC.

CONDENSED STATEMENTS OF CASH FLOWS
For the nine months ended September 30, 2010 and 2009
(in thousands)
(unaudited)


	For the nine months ended
	September 30,
	2010			2009
Cash flows from operating activities:
Net loss	$	(22,523	)	$	(13,641	)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation		44			248
Amortization		179			179
Change in fair value of derivative instruments		8,003			(286	)
Non-cash interest expense		5,027			3,701
Non-cash compensation expense		685			1,301
Gain on disposal of fixed assets		(1	)		(824	)
Changes in assets and liabilities excluding non-cash transactions:
Decrease in accounts receivable		99			211
Increase in inventory		(24	)		—
Increase in deposits on inventory		(420	)
Decrease in prepaid expenses and other current assets		33			20
Increase in deferred revenue		2,069			149
Decrease (increase) in accounts payable and accrued expenses		(516	)		2,160
Increase in other current liabilities		415			31
Decrease in deferred lease liability		(25	)		(39	)
Decrease in restructuring accrual		(300	)		(1,627	)

Total adjustments		15,268			5,224

Net cash used in operating activities		(7,255	)		(8,417	)

Net cash provided by investing activities — proceeds from sale of fixed assets		1			880

Cash flows from financing activities:
Proceeds from notes payable		500
Payments on notes payable		(525	)
Proceeds from the issuance of common stock		6,674			7,298

Net cash provided by financing activities		6,649			7,298

Net decrease in cash and cash equivalents		(605	)		(239	)
Cash and cash equivalents, beginning of period		3,566			7,214

Cash and cash equivalents, end of period	$	2,961		$	6,975

Schedule of non-cash financing activities
Common stock issued to settle accrued Directors compensation	$	11		$	—
Exchange of debt as deferred revenue (Note 8)	$	13,000		$	—

The accompanying notes are an integral part of the financial statements.

EMISPHERE TECHNOLOGIES, INC.

NOTES TO CONDENSED FINANCIAL STATEMENTS

1. Nature of Operations and Liquidity

Nature of Operations.Emisphere Technologies, Inc. (“Emisphere”, “our”, “us”, the “Company” or “we”) is a biopharmaceutical company that focuses on improving delivery of therapeutic molecules, pharmaceutical compounds, and nutritional supplements using its Eligen^® Technology. These molecules, compounds and supplements could be currently available or are in pre-clinical or clinical development.

Our core business strategy is to develop oral forms of drugs or nutritional supplements that are not currently available or have poor bioavailability in oral form, either alone or with corporate partners, by applying the Eligen^® Technology to those drugs or nutritional supplements. Typically, the drugs or nutritional supplements that we target have received regulatory approval, have demonstrated safety and efficacy, and are currently available on the market.

Liquidity.As of September 30, 2010, we had approximately $3.2 million in cash and restricted cash, approximately $11.4 million in working capital deficiency, a stockholders’ deficit of approximately $60.9 million and an accumulated deficit of approximately $459.2 million. Net income was $9.6 million and operating loss was $3.9 million for the three months ended September 30, 2010. Net loss and operating loss for the nine months ended September 30, 2010 were $22.5 million and $10.0 million, respectively.

On August 25, 2010, the Company entered into a securities purchase agreement (together with the securities purchase agreement with MHR and its affiliates, as described below, the “August 2010 Financing”) with certain institutional investors pursuant to which the Company agreed to sell an aggregate of 3,497,528 shares of its common stock and warrants to purchase a total of 2,623,146 additional shares of its common stock for total gross proceeds of $3,532,503. Each unit, consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock, was sold at a purchase price of $1.01. The warrants to purchase additional shares are exercisable at a price of $1.26 per share and will expire 5 years from the date of issuance. In accordance with the terms of a registration rights agreement with the investors, the Company filed a registration statement on September 15, 2010, which was declared effective October 12, 2010. On August 25, 2010, the Company also announced that it had entered into a separate securities purchase agreement with MHR Fund Management LLC (together with its affiliates, “MHR”) as part of the August 2010 Financing, pursuant to which the Company agreed to sell an aggregate of 3,497,528 shares of its common stock and warrants to purchase a total of 2,623,146 additional shares of its common stock for total gross proceeds of $3,532,503. Each unit, consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock, was sold at a purchase price of $1.01. The warrants to purchase additional shares are exercisable at a price of $1.26 per share and will expire 5 years from the date of issuance.

The Company received total net proceeds from the August 2010 Financing of approximately $6.7 million after deducting fees and expenses and excluding the proceeds, if any, from the exercise of the warrants that will be issued in the transactions. Proceeds from these transactions will be used to fund the Company’s operations (including investments in new product development and commercialization), to satisfy certain debts of the Company, to settle certain outstanding litigation and to meet the Company’s obligations as they may arise.

In connection with the August 2010 Financing, the Company entered into a waiver agreement with MHR (the “Waiver Agreement”), pursuant to which MHR waived certain anti-dilution adjustment rights under its 11% senior secured notes and warrants issued by the Company to MHR in September 2006 that would otherwise have been triggered by the private placement described above. As consideration for such waiver, the Company issued to MHR a warrant to purchase 975,000 shares of common stock and agreed to reimburse MHR for 50% of its legal fees up to a maximum reimbursement of $50,000. The terms of such warrant are identical to the warrants issued to MHR in the transaction described above. The Company was advised in these transactions by an independent committee of the Board of Directors. Roth Capital Partners served as the placement agent for the offering.

On July 29, 2010, we issued a promissory note (the “July 2010 MHR Note”) to MHR in the principal amount of $525,000. The July 2010 MHR Note provided for an interest rate of 15% per annum, with the entire principal amount due and payable on October 27, 2010 (the “Maturity Date”). The July 2010 MHR Note also provided that the Maturity Date would be accelerated, in certain circumstances, to the date that is two business days following the receipt by the Issuer of at least $1,000,000 aggregate cash proceeds from third parties, whether in connection with certain financing transactions, commercial transactions or otherwise. Pursuant to the terms of the July 2010 MHR Note, the August 2010 Financing triggered the provision under which the Maturity Date was accelerated and the July 2010 MHR Note was paid during the quarter ended September 30, 2010.

In April 2005, the Company entered into an amended and restated employment agreement with its then Chief Executive Officer, Dr. Michael M. Goldberg, for services through July 31, 2007. On January 16, 2007, the Board of Directors terminated Dr. Goldberg’s services. On April 26, 2007, the Board of Directors held a special hearing at which it determined that Dr. Goldberg’s termination was for cause. On March 22, 2007, Dr. Goldberg, through his counsel, filed a demand for arbitration asserting that his termination was without cause and seeking approximately $1.05 million plus attorney’s fees, interest, arbitration costs and other relief alleged to be owed to him in connection with his employment agreement with the Company. During the arbitration, Dr. Goldberg sought a total damage amount of at least $9.2 million plus interest. On February 11, 2010, the arbitrator issued the final award in favor of Dr. Goldberg for a total amount of approximately $2.3 million plus interest and fees relating to confirmation of the award. The Company opposed Dr. Goldberg’s petition to confirm the arbitration award. On July 12, 2010 the award was confirmed by the court. As of August 10, 2010, the Company adjusted its estimate of costs to settle this matter to approximately $2.6 million to account for potential additional interest costs on the settlement amount and additional legal fees. On September 23, 2010, the Company paid approximately $2.6 million as full and final settlement of this matter.

On June 4, 2010, we entered into a Master Agreement and Amendment (the “Novartis Agreement”) with Novartis Pharma AG (“Novartis”). Pursuant to the Novartis Agreement, the Company was released and discharged from its obligations under the convertible promissory note issued by us to Novartis on December 1, 2004 (the “Novartis Note”) in exchange for (i) the reduction of future royalty and milestone payments up to an aggregate amount of $11.0 million due the Company under the Research Collaboration and Option Agreement, dated as of December 3, 1997, as amended on October 20, 2000, and the License Agreement, date as of March 8, 2000, for the development of an oral salmon calcitonin product for the treatment of osteoarthritis and osteoporosis; (ii) the right for Novartis to evaluate the feasibility of using Emisphere’s Eligen^® Technology with two new compounds to assess the potential for new product development opportunities; and (iii) other amendments to the Research Collaboration and Option Agreement and License Agreement. As of the date of the Novartis Agreement, the outstanding principal balance and accrued interest of the Novartis Note was approximately $13.0 million.

We anticipate that we will continue to generate significant losses from operations for the foreseeable future and that our business will require substantial additional investment that we have not yet secured. As such, we anticipate that our existing cash resources will enable us to continue operations through approximately December 2010 or earlier if unforeseen events arise that negatively affect our liquidity. Further, we have significant future commitments and obligations. These conditions raise substantial doubt about our ability to continue as a going concern. Consequently, the audit opinion issued by our independent registered public accounting firm relating to our financial statements for the year ended December 31, 2009 contained a going concern explanatory paragraph. We are pursuing new as well as enhanced collaborations and exploring other financing options, with the objective of minimizing dilution and disruption.

financial condition and results of operations, and could force us to reduce or cease our operations. No adjustment has been made in the accompanying financial statements to the carrying amount and classification of recorded assets and liabilities should we be unable to continue operations.

2. Basis of Presentation

The condensed balance sheet at December 31, 2009 was derived from audited financial statements but does not include all disclosures required by accounting principles generally accepted in the United States of America. The other information in these condensed financial statements is unaudited but, in the opinion of management, reflects all adjustments necessary for a fair presentation of the results for the periods covered. All such adjustments are of a normal recurring nature unless disclosed otherwise. These condensed financial statements, including notes, have been prepared in accordance with the applicable rules of the Securities and Exchange Commission and do not include all of the information and disclosures required by accounting principles generally accepted in the United States of America for complete financial statements. These condensed financial statements should be read in conjunction with the financial statements and additional information as contained in our Annual Report on Form 10-K for the year ended December 31, 2009.

3. Stock-Based Compensation Plans

On April 20, 2007, the stockholders of the Company approved the 2007 Stock Award and Incentive Plan (the “2007 Plan”). The 2007 Plan provides for grants of options, stock appreciation rights, restricted stock, deferred stock, bonus stock and awards in lieu of obligations, dividend equivalents, other stock-based awards and performance awards to executive officers and other employees of the Company, and non-employee directors, consultants and others who provide substantial service to us. The 2007 Plan provides for the issuance of an aggregate of 3,275,334 shares as follows: 2,500,000 new shares, 374,264 shares remaining and transferred from the Company’s 2000 Stock Option Plan (the “2000 Plan”), (which was then replaced by the 2007 Plan) and 401,070 shares remaining and transferred from the Company’s Stock Option Plan for Outside Directors (the “Directors Stock Plan”). In addition, shares canceled, expired, forfeited, settled in cash, settled by delivery of fewer shares than the number underlying the award, or otherwise terminated under the 2000 Plan will become available for issuance under the 2007 Plan. Prior to the adoption of the 2007 Plan, the Company granted stock-based compensation to employees under the 2000 Plan and the 2002 Broad Based Plan (the “2002 Plan”), and to non-employee directors under the Directors Stock Plan. The Company also has grants outstanding under various expired and terminated stock plans, including the 1991 Stock Option Plan, the 1995 Non-Qualified Stock Option Plan, the Deferred Directors Compensation Stock Plan and Non-Plan Options. In January 2007, the Directors Stock Plan expired. As of September 30, 2010, shares available for future grants under the 2007 Plan, including options made available under the 2000 Plan, amounted to 1,375,048.

Total compensation expense recorded during the nine months ended September 30, 2010 for share-based payment awards was $0.69 million, of which $0.10 million is included in research and development and $0.59 million is included in general and administrative expenses in the condensed statement of operations for the nine months ended September 30, 2010. Total compensation expense recorded during the nine months ended September 30, 2009 for share-based payment awards was $1.30 million, of which $0.09 million is included in research and development and $1.21 million is included in general and administrative expenses in the condensed statement of operations for the nine months ended September 30, 2009. At September 30, 2010, total unrecognized estimated compensation expense related to non-vested stock options granted prior to that date was $0.7 million, which is expected to be recognized over a weighted-average period of approximately two years. No options were exercised in the nine months ended September 30, 2010 or 2009. No tax benefit was realized due to a continued pattern of operating losses.

During the nine months ended September 30, 2010, the Company granted options for 662,750 shares with a weighted average exercise price of $1.41.

4. Inventories

Inventories are stated at the lower of cost or market determined by the first in, first out method. Inventories consist principally of finished goods at September 30, 2010 and December 31, 2009.

5. Fixed Assets

Equipment and leasehold improvements, net, consists of the following:


	Useful Lives		September 30,		December 31,
	in Years		2010		2009
			(in thousands)
Equipment		3-7	$	1,370	$	1,370
Leasehold improvements	Term of lease			61		61

				1,431		1,431
Less, accumulated depreciation and amortization				1,337		1,293

Equipment and leasehold improvements, net			$	94	$	138

6. Purchased Technology

Purchased technology represents the value assigned to patents and the rights to utilize, sell or license certain technology in conjunction with our proprietary carrier technology. These assets are utilized in various research and development projects. Purchased technology is amortized over a period of 15 years, which represents the average life of the patents.


	September 30,		December 31,
	2010		2009
	(in thousands)
Gross carrying amount	$	4,533	$	4,533
Less, accumulated amortization		3,636		3,456

Net book value	$	897	$	1,077

Amortization expense for the purchased technology is approximately $60 thousand per quarter in 2010 and in the remaining years through 2014.

7. Accounts Payable and Accrued Expenses

Accounts payable and accrued expenses consist of the following:


	September 30,		December 31,
	2010		2009
	(In thousands)
Accounts payable and other accrued expenses	$	3,217	$	1,979
Accrued cost of lawsuit		—		2,333
Accrued bonus		713		150
Accrued legal, professional fees and other		346		302
Accrued vacation		116		81
Clinical trial expenses and contract research		8		130

	$	4,400	$	4,975

8. Notes Payable

Notes payable consist of the following:


	September 30,		December 31,
	2010		2009
	(in thousands)
MHR Convertible Notes	$	15,355	$	13,076
June 2010 MHR Promissory Notes		508		—
Novartis Note		—		12,588

	$	15,863	$	25,664

MHR Convertible Notes.The convertible notes issued to MHR on September 26, 2005 are due on September 26, 2012, bear interest at 11% and are secured by a first priority lien in favor of MHR on substantially all of our assets (the “MHR Convertible Notes”). Interest is payable in the form of additional MHR Convertible Notes issued monthly through March 31, 2007 and then semi-annually beginning June 30, 2008, rather than in cash. The MHR Convertible Notes are convertible, at the sole discretion of MHR or any assignee thereof through September 25, 2012, into shares of our common stock at a price per share of $3.78. At September 30, 2010, the MHR Convertible Notes were convertible into 6,495,250 shares of our common stock. In connection with the issuance of the MHR Convertible Notes, we amended MHR’s then existing warrants to purchase 387,374 shares of our common stock to provide for additional anti-dilution protection. MHR was also granted the option to purchase warrants for up to an additional 617,211 shares of our common stock (the “Warrant Purchase Option”) at a price per warrant equal to $0.01 per warrant for each of the first 67,084 warrants and $1.00 per warrant for each additional warrant. This option was exercised by MHR in April 2006. See Note 9 for a further discussion of the liability related to these warrants.

The book value of the MHR Convertible Notes is comprised of the following:


	September 30,			December 31,
	2010			2009
	(in thousands)
Face Value of the notes	$	24,552		$	22,616
Discount (related to the embedded conversion feature)		(627	)		(793	)
Discount (related to the warrant purchase option)		(6,206	)		(7,848	)
Discount (related to 2010 debt modification)		(1,653	)		—
Lender’s financing costs		(711	)		(899	)

	$	15,355		$	13,076

The debt discount, lenders finance costs, deferred financing costs and amounts attributed to derivative instruments are being amortized to interest expense over the life of the MHR Convertible Notes using an interest method to yield an effective interest rate of 41.2%.

In connection with the MHR Note Financing, the Company agreed to appoint a representative of MHR (the “MHR Nominee”) and another person (the “Mutual Director”) to its Board of Directors. Further, the Company amended its certificate of incorporation to provide for continuity of the MHR Nominee and the Mutual Director on the Board, as described therein, so long as MHR holds at least 2% of the outstanding common stock of the Company.

The MHR Convertible Notes provide for various events of default. On May 5, 2006, we received an executed waiver from MHR (the “Waiver”) providing for a temporary waiver of defaults, which were not payment-related, under the loan agreement between Emisphere and MHR. We have received extensions of such Waiver from time to time, the latest being received October 25, 2010 and is in effect through November 16, 2011; as such the MHR Convertible Notes have been classified as long-term. Effective January 1, 2009, the Company adopted the provisions of the Financial Accounting Standards Board Accounting Codification Topic 815-40-15-5, “Evaluating Whether an Instrument Involving a Contingency is Considered Indexed to an Entity’s Own Stock” (“FASB ASC 815-40-15-5”). Under FASB ASC 85-40-15-5, the conversion feature embedded in the MHR Convertible Notes have been bifurcated from the host contract and accounted for separately as a derivative. The bifurcation of the embedded derivative increased the amount of debt discount thereby reducing the book value of the MHR Convertible Notes and increasing prospectively the amount of interest expense to be recognized over the life of the MHR Convertible Notes.

In connection with the June 2010 MHR Promissory Notes (described below) as consideration for its consent, limitation of rights and pledge to enter into the Future Transaction Agreement in connection with the MHR Letter Agreement, the Company granted MHR warrants to purchase 865,000 shares of its Common Stock. See Note 9 for more information on the “Novartis Note” Warrants. The Company determined that the modification of the MHR Convertible Debt agreement was not a substantial modification in accordance with ASC 470-50, “Modifications and Extinguishments”. As such, the warrants issued to MHR were recorded as a debt discount to the MHR Convertible Debt and are being amortized to interest expense over the remaining term of the debt.

Novartis Note.The Convertible Promissory Note was issued by us to Novartis on December 1, 2004 (the “Novartis Note”), in accordance with and pursuant to the terms and conditions therein and was originally due on December 1, 2009. The Novartis Note was issued in a private placement transaction pursuant to Section 4(2) of the Securities Act in connection with a new research collaboration option relating to the development of PTH-1-34. The Novartis Note accrued interest at a rate of 7%. The Novartis Note was originally due December 1, 2009. On November 30, 2009, Novartis agreed to extend the maturity date to February 26, 2010. On February 23, 2010, Novartis agreed to extend the maturity date to May 26, 2010. On May 27, 2010, Novartis agreed to a further extension through June 4, 2010. On June 4, 2010, the Company and Novartis entered into a Master Agreement and Amendment (the “Novartis Agreement”). Pursuant to the Novartis Agreement, the Company was released and discharged from its obligations under the Novartis Note in exchange for (i) the reduction of future royalty and milestone payments up to an aggregate amount of $11.0 million due the Company under the Research Collaboration and Option Agreement, dated as of December 3, 1997, as amended on October 20, 2000, and the License Agreement, date as of March 8, 2000, for the development of an oral salmon calcitonin product for the treatment of osteoarthritis and osteoporosis; (ii) the right for Novartis to evaluate the feasibility of using Emisphere’s Eligen^® Technology with two new compounds to assess the potential for new product development opportunities; and (iii) other amendments to the Research Collaboration and Option Agreement and License Agreement. As of the date of the Novartis Agreement, the outstanding principal balance and accrued interest of the Novartis Note was approximately $13.0 million. The Company recognized the full value of the debt released as consideration for the transfer of the rights and other intangibles to Novartis and deferred the related revenue in accordance with applicable accounting guidance for the sale of rights to future revenue until the earnings process has been completed based on achievement of certain milestones or other deliverables.

June 2010 MHR Promissory Notes.In connection with the Novartis Agreement, on June 8, 2010, the Company and MHR entered into a letter agreement (the “MHR Letter Agreement”), and on June 4, 2010, MHR, the Company and Novartis entered into a non-disturbance agreement (the “Non-Disturbance Agreement”), which was a condition to Novartis’ execution of the Novartis Agreement. Pursuant to the MHR Letter Agreement, MHR agreed to limit certain rights and courses of action that it would have available to it as a secured party under the Senior Secured Term Loan Agreement and Pledge and Security Agreement between MHR and the Company (the “Loan and Security Agreement”). MHR also consented to the Novartis Agreement, which consent is required under the Loan and Security Agreement, and MHR also agreed to enter into a comparable agreement at some point in the future in connection with another potential Company transaction (the “Future Transaction Agreement”). The MHR Letter Agreement also provides for the Company to reimburse MHR for its legal fees incurred in connection with the Non-Disturbance Agreement for up to $500,000 and up to $100,000 in legal expenses incurred by MHR in connection the Future Transaction Agreement. The reimbursements are to be paid in the form of non-interest bearing promissory notes issued on the effective date of the MHR Letter Agreement. As such, the Company issued to MHR non-interest promissory notes for $500,000 and $100,000 on June 8, 2010. The Company received documentation that MHR expended more than $500,000 of legal fees in connection with the Non-Disturbance Agreement and consequently recorded the issuance of the $500,000 promissory note and a corresponding charge to financing expenses. When the $100,000 promissory note was originally written, the Company had not received documentation or communication that indicated MHR had incurred legal fees in connection with the Future Transaction Agreement. Therefore, the issuance of the $100,000 promissory note was recorded as a prepaid expense. However, the Company has since received documentation that MHR has expended more than $100,000 legal fees in connection with the Future Transaction Agreement and consequently the prepaid expense was eliminated and a corresponding charge to financing expense was recognized. The promissory notes are due June 4, 2012. The Company imputed interest at its incremental borrowing rate of 10%, and discounted the face amounts of the $500,000 and $100,000 promissory notes by $87,000 and $18,000, respectively. The debt discount is being amortized to interest expense over the life of the June 2010 MHR Promissory Notes using an interest method to yield an effective interest rate of 10.5%.

Additionally, as consideration for its consent, limitation of rights and pledge to enter into the Future Transaction Agreement in connection with the MHR Letter Agreement, the Company granted MHR warrants to purchase 865,000 shares of its Common Stock. See Note 9 for more information on the “Novartis Note” Warrants. The Company determined that the modification of the MHR Convertible Debt agreement was not a substantial modification in accordance with ASC 470-50, “Modifications and Extinguishments”. As such, the warrants issued to MHR were recorded as a debt discount to the MHR Convertible Debt and are being amortized to interest expense over the remaining term of the debt.

July 2010 MHR Promissory Note.On July 29, 2010, we issued the July 2010 MHR Note in the principal amount of $525,000. The July 2010 MHR Note provides for an interest rate of 15% per annum, with the entire principal amount due and payable on October 27, 2010. During the quarter ended September 30, 2010, certain conditions were met which pursuant to the terms of the July 2010 MHR Note, the Maturity Date was accelerated and the note was paid.

9. Derivative Instruments

Derivative instruments consist of the following:


	September 30,		December 31,
	2010		2009
	(in thousands)
Elan Warrants	$	—	$	394
MHR Convertible Note		8,557		4,591
MHR Warrants		252		213
August 2007 Equity financing warrants		192		141
August 2009 equity financing warrants		3,412		5,092
August 2009 equity financing warrants to placement agent		—		349
June 2010 MHR Warrants		648		—
August 2010 equity financing warrants		4,550		—
August 2010 MHR waiver warrants		846		—

	$	18,457	$	10,780

Elan Warrant. In connection with a restructuring of debt in March 2005, we issued to Elan Corporation, plc (“Elan”) a warrant to purchase up to 600,000 shares of our common stock at an exercise price of $3.88 (the “Elan Warrant”). The Elan Warrant provides for adjustment of the exercise price upon the occurrence of certain events, including the issuance by Emisphere of common stock or common stock equivalents that have an effective price that is less than the exercise price of the warrant. The anti-dilution feature of the Elan Warrant was triggered in connection with an equity financing conducted in August 2007 (the “August 2007 Financing”), resulting in an adjustment to the exercise price to $3.76. The anti-dilution feature of the Elan Warrant was triggered again in connection with an equity financing conducted in August 2009 (the “August 2009 Financing), resulting in an adjustment to the exercise price to $0.4635. The Company adopted the provisions of FASB ASC 815-40-15-5 effective January 1, 2009. Under FASB ASC 815-40-15-5, the Elan Warrant is not considered indexed to the Company’s own stock and, therefore, does not meet the scope exception in FASB ASC 815-10-15 and thus needs to be accounted for as a derivative liability. On April 20, 2010, Elan notified the Company of its intention to exercise the Elan Warrant using the “cashless exercise” provision. The Company issued 518,206 shares of common stock to Elan in accordance with the terms of the cashless exercise provision on April 21, 2010. After the cashless exercise, the Elan Warrant is no longer outstanding. The Company calculated the fair value of the Elan warrants on April 21, 2010 using the Black-Scholes option pricing model. The assumptions used in computing the fair value as of April 21, 2010 are a closing stock price of $3.40, expected volatility of 89.91% over the remaining contractual life of four months and a risk-free rate of 0.16%. The fair value of the Elan warrants increased by $0.6 million and $1.4 million during the three and nine months ended September 30, 2010, respectively, which has been recognized in the accompanying statements of operations. The fair value of the derivative liability at April 21, 2010 of $1.8 million was reclassified to additional paid-in-capital.

Embedded Conversion Feature of MHR Convertible Notes.The MHR Convertible Notes contain a provision whereby, the conversion price is adjustable upon the occurrence of certain events, including the issuance by Emisphere of common stock or common stock equivalents at a price which is lower than the current conversion price of the MHR Convertible Notes and lower than the current market price. However, the adjustment provision does not become effective until after the Company raises $10 million through the issuance of common stock or common stock equivalents at a price which is lower than the current conversion price of the MHR Convertible Notes and lower than the current market price during any consecutive 24 month period. The Company adopted the provisions of FASB ASC 815-40-15-5 effective January 1, 2009. Under FASB ASC 815-40-15-5, the embedded conversion feature is not considered indexed to the Company’s own stock and, therefore, does not meet the scope exception in FASB ASC 815-10-15 and thus needs to be accounted for as a derivative liability. The liability has been presented as a non-current

liability to correspond with its host contract, the MHR Convertible Notes. The fair value of the embedded conversion feature is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility 136.54% over the remaining term of two years and a risk-free rate of 0.42%. The fair value of the embedded conversion feature decreased by $3.5 million and increased by $4.0 million during the three and nine months ended September 30, 2010, respectively, which has been recognized in the accompanying statements of operations. The embedded conversion feature will be adjusted to fair value for each future period it remains outstanding.

MHR 2006 Warrants.In connection with the exercise in April 2006 of the Warrant Purchase Option discussed in Note 8 above, the Company issued warrants for 617,211 shares to MHR for proceeds of $0.6 million (the “MHR 2006 Warrants”). The MHR 2006 Warrants have an original exercise price of $4.00 and are exercisable through September 26, 2011. The MHR 2006 Warrants have the same terms as the 2007 Warrants (as defined below), with no limit upon adjustments to the exercise price. The anti-dilution feature of the MHR 2006 Warrants was triggered in connection with the August 2007 Financing, resulting in an adjusted exercise price of $3.76. Based on the provisions of FASB ASC 815, “Derivatives and Hedging,” the MHR 2006 Warrants have been determined to be an embedded derivative instrument which must be separated from the host contract. The MHR 2006 Warrants contain the same potential cash settlement provisions as the 2007 Warrants and therefore they have been accounted for as a separate liability. The fair value of the warrants is estimated, at the end of each quarterly period, using the Black-Scholes option pricing model. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 141.59% over the remaining term of one year and a risk-free rate of 0.27%. The fair value of the MHR 2006 Warrants decreased by $0.5 million and increased by $0.04 million during the three and nine months ended September 30, 2010, respectively, which has been recognized in the accompanying statements of operations. The MHR 2006 Warrants will be adjusted to estimated fair value for each future period they remain outstanding. See Note 8 for a further discussion of the MHR Note.

August 2007 Equity Financing Warrants.In connection with the August 2007 Financing, Emisphere sold warrants to purchase up to 400,000 shares of common stock (the “2007 Warrants”). Of the 2007 Warrants originally issued, 91,073 were sold to MHR. Each of the 2007 Warrants were issued with an exercise price of $3.948 and expire on August 21, 2012. The 2007 Warrants provide for certain anti-dilution protection as provided therein. Under the terms of the 2007 Warrants, we have an obligation to make a cash payment to the holders of the warrants for any gain that could have been realized if the holders exercise the warrants and we subsequently fail to deliver a certificate representing the shares to be issued upon such exercise by the third trading day after such warrants have been exercised. Accordingly, the 2007 Warrants have been accounted for as a liability. The fair value of the 2007 Warrants is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The 2007 Warrants were accounted for with an initial value of $1.0 million on August 22, 2007. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 135.26% over the remaining term of one year and eleven months and a risk-free rate of 0.42%. The fair value of the 2007 Warrants decreased by $0.5 million and increased by $0.05 million during the three and nine months ended September 30, 2010, respectively, and the fluctuations have been recorded in the statements of operations. The 2007 Warrants will be adjusted to estimated fair value for each future period they remain outstanding.

August 2009 Equity Financing Investors Warrants.In connection with the August 2009 Financing, Emisphere sold warrants to purchase 6.4 million shares of common stock, consisting of warrants to purchase 3.7 million shares of common stock to MHR (the “2009 MHR Warrants”) and warrants to purchase 2.7 million shares of common stock to other unaffiliated investors (the “2009 Investor Warrants” and, together with the 2009 MHR Warrants, the “2009 Warrants”). The 2009 Warrants were issued with an exercise price of $0.70 and expire on August 21, 2014. Under the terms of the 2009 Warrants, we have an obligation to make a cash payment to the holders of the warrants for any gain that could have been realized if the holders exercise the warrants and we subsequently fail to deliver a certificate representing the shares to be issued upon such exercise by the third trading day after such warrants have been exercised. Accordingly, the 2009 Warrants have been accounted for as a liability. The fair value of the 2009 Warrants is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 111.93% over the remaining term of three years and eleven months and a risk-free rate of 0.64%. The fair value of the 2009 Warrants decreased by $6.8 million and increased by $0.5 million for the three and nine months

ended September 30, 2010, respectively and the fluctuation has been recorded in the statements of operations. The 2009 Warrants will be adjusted to estimated fair value for each future period they remain outstanding. During the nine months ended September 30, 2010, the unaffiliated investors notified the Company of their intention to exercise their 2009 Investor Warrant to purchase up to 2,685,714 shares of the Company’s common stock at an exercise price of $0.70, using the “cashless exercise” provision. The Company issued an aggregate 1,966,937 to the unaffiliated investors in accordance with the terms of the cashless exercise provision. The Company calculated the fair value of the 2,685,714 exercised warrants on their respective exercise dates using the Black-Scholes option pricing model. The weighted average assumptions used in computing the fair values are a closing stock price of $1.91, expected volatility of 101.99% over the remaining contractual life of four years and three months and a risk-free rate of 1.46%. The fair value of the 2.7 million exercised warrants decreased by $2.7 million and increased by $2.2 million during the three and nine months ended September 30, 2010, respectively, which has been recognized in the accompanying statements of operations. The fair value of the derivative liabilities at the exercise dates of $4.3 million was reclassified to additional paid-in-capital. After these cashless exercises, 2009 Warrants to purchase up to 3,729,323 shares of common stock, in the aggregate, remain outstanding.

August 2009 Equity Financing Placement Agent Warrants.In connection with the August 2009 Financing, Emisphere issued to Rodman & Renshaw, LLC (the “Placement Agent”), as part of the compensation for acting as placement agent for the August 2009 Financing, warrants to purchase 504,000 shares of common stock (the “Placement Agent Warrants”). The Placement Agent Warrants were issued with an exercise price of $0.875 and expiration date of October 1, 2012. During the second quarter of 2010, the Placement Agent Warrants were exercised and are no longer outstanding.

June 2010 MHR Warrants.As consideration for its consent and limitation of rights in connection with the Novartis Agreement, the Company granted MHR warrants to purchase 865,000 shares of its common stock (the “Novartis Note Warrants”) under the MHR Letter Agreement. The warrants are exercisable at $2.90 per share and will expire on August 21, 2014. The Novartis Note Warrants provide for certain anti-dilution protection as provided therein. We have an obligation to make a cash payment to the holders of the warrants for any gain that could have been realized if the holders exercise the warrants and we subsequently fail to deliver a certificate representing the shares to be issued upon such exercise by the third trading day after such warrants have been exercised. Accordingly, the Novartis Note Warrants have been accounted for as a liability. Their fair value is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The Company estimated the fair value of the Novartis Note Warrants on the date of grant using the Black-Scholes option pricing model to be $1.9 million which was recorded as a debt discount to the MHR Convertible Notes (see Note 8). The assumptions used in computing the fair value of the Novartis Note Warrants were a closing stock price of $3.15, expected volatility of 93.22% over the term of 4.2 years and a risk free rate of 1.02%. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 111.93% over the remaining term of three years and eleven months at a risk-free rate of 0.64%. The fair value of the Novartis Note Warrants decreased by $1.2 million for the three and nine months ended September 30, 2010, respectively and the fluctuation has been recorded in the statements of operations.

August 2010 Equity Financing Warrants.In connection with the August 2010 Financing, Emisphere sold warrants to purchase 5.2 million shares of common stock, consisting of warrants to purchase 2.6 million shares of common stock to MHR (the “2010 MHR Warrants”) and warrants to purchase 2.6 million shares of common stock to other unaffiliated investors (the “2010 Investor Warrants” and, together with the 2010 MHR Warrants, the “2010 Warrants”). The 2010 Warrants were issued with an exercise price of $1.26 and expire on August 26, 2015. Under the terms of the 2010 Warrants, we have an obligation to make a cash payment to the holders of the warrants for any gain that could have been realized if the holders exercise the warrants and we subsequently fail to deliver a certificate representing the shares to be issued upon such exercise by the third trading day after such warrants have been exercised. Additionally, until the six month anniversary of the issue date of the Warrants the exercise price is adjustable, unless waived, upon the occurrence of certain events, including the issuance by Emisphere of common stock or common stock equivalents at a price which is lower than the current exercise price of the Warrants and lower than the current market price. Accordingly, the 2010 Warrants have been accounted for as a liability. The fair value of the 2010 Warrants is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The Company estimated the fair value of the warrants on the date of grant using the Black-Scholes option pricing model to be $4.1 million. The assumptions used in computing the fair value of the 2010 Warrants were a

closing stock price of $1.05, expected volatility of 103.10% over the term of five years and a risk free rate of 1.40%. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 104.62% over the remaining term of four years and eleven months and a risk-free rate of 1.27%. The fair value of the 2010 Warrants increased by $0.4 million from the date of issue until the quarter ended September 30, 2010 and the fluctuation has been recorded in the statements of operations. The 2010 Warrants will be adjusted to estimated fair value for each future period they remain outstanding.

MHR August 2010 Waiver Warrants. In connection with the August 2010 Financing, the Company entered into a waiver agreement with MHR (“Waiver Agreement”), pursuant to which MHR waived certain anti-dilution adjustment rights under the MHR Senior Secured Notes and certain warrants issued by the Company to MHR that would otherwise have been triggered by the August 2010 Financing. As consideration for such waiver, the Company issued to MHR warrants (the “MHR Waiver Warrants”) to purchase 975,000 shares of its common stock (the “MHR Waiver Warrant Shares”). The MHR Waiver Warrants are in the same form of warrant as the 2010 MHR Warrants described above. Accordingly, the MHR Waiver Warrants have been accounted for as a liability. The fair value of the MHR Waiver Warrants is estimated, at the end of each quarterly reporting period, using the Black-Scholes option pricing model. The Company estimated the fair value of the warrants on the date of grant using the Black-Scholes option pricing model to be $0.8 million. The assumptions used in computing the fair value of the MHR Waiver Warrants were a closing stock price of $1.05, expected volatility of 103.10% over the term of five years and a risk free rate of 1.40%. The assumptions used in computing the fair value as of September 30, 2010 are a closing stock price of $1.15, expected volatility of 104.62% over the remaining term of four years and eleven months and a risk-free rate of 1.27%. The fair value of the MHR Waiver Warrants increased by $0.1 million from the date of issue until the quarter ended September 30, 2010 and the fluctuation has been recorded in the statements of operations. The MHR Waiver Warrants will be adjusted to estimated fair value for each future period they remain outstanding.

10. Stockholders Deficit

On August 26, 2010, we completed the sale of 3,497,528 shares of common stock and 2,623,146 warrants to purchase shares of common stock to certain institutional investors for gross proceeds of $3,532,503. Also, on August 26, 2010, we completed the sale of 3,497,528 shares of common stock and 2,623,146 warrants to purchase shares of common stock to MHR for gross proceeds of $3,532,503. Proceeds from the offering were $6.7 million net of cash issuance costs of $0.4 million. Additional issuance costs consisted of $0.8 million from the issuance of 975,000 warrants issued to MHR and $50,000 in accrued expenses to reimburse MHR for up to 50% of its legal fees in consideration of waiving certain anti-dilution adjustments rights under the MHR Convertible Notes and certain warrants issued by the Company to MHR that would otherwise have been triggered by the August 2010 Financing.

11. Net loss per share

The following table sets forth the information needed to compute basic earnings per share:


	Three Months Ended					Nine Months Ended
	September 30,					September 30,
	2010		2009			2010			2009
	(in thousands except per share data)					(in thousands except per share data)
Basic net income (loss)	$	9,647	$	(4,037	)	$	(22,523	)	$	(13,641	)

Weighted average common shares outstanding		47,401,395		35,695,769			44,291,889			32,188,554
Dilutive securities:
Warrants		3,111,108		—			—			—
Options		410,378		—			—			—

Diluted average common stock equivalents outstanding		50,922,881		35,695,769			44,291,889			32,188,554

Basic net income (loss) per share		0.20		(0.11	)		(0.51	)		(0.42	)

Diluted net income (loss) per share		0.19		(0.11	)		(0.51	)		(0.42	)

For the nine months ended September 30, 2010 and 2009, certain potential shares of common stock have been excluded from diluted loss per share because the exercise price was greater than the average market price of our common stock, and therefore, the effect on diluted loss per share would have been anti-dilutive. The following table sets forth the number of potential shares of common stock that have been excluded from diluted net loss per share because their effect was anti-dilutive:


	Three Months Ended				Nine Months Ended
	September 30,				September 30,
	2010		2009		2010		2009
Options to purchase common shares		2,815,088		2,878,816		3,225,466		2,878,816
Outstanding warrants		8,721,717		9,934,253		11,832,826		9,934,253
Novartis convertible note payable		—		15,560,566		—		15,560,566
MHR note payable	��	6,495,250		5,821,584		6,495,250		5,821,584

		18,032,055		34,195,219		21,553,542		34,195,219

12. Commitments and Contingencies

Commitments.At the beginning of 2009 we had leased approximately 80,000 square feet of office space at 765 Old Saw Mill River Road, Tarrytown, NY for use as administrative offices and laboratories. The lease for our administrative and laboratory facilities had been set to expire on August 31, 2012. However, on April 29, 2009, the Company entered into a Lease Termination Agreement (the “Agreement”) with BMR-Landmark at Eastview, LLC, a Delaware limited liability company (“BMR”) pursuant to which the Company and BMR terminated the lease of space at 765 Old Saw Mill River Road in Tarrytown, NY. Pursuant to the Agreement, the Lease was terminated effective as of April 1, 2009. The Agreement provided that the Company make the following payments to BMR: (a) $1 million, paid upon execution of the Agreement, (b) $0.5 million, paid six months after the execution date of the Agreement, and (c) $0.75 million, payable twelve months after the execution date of the Agreement. Initial and six months payments were made on schedule. Although the final payment was due originally on April 29, 2010, on March 17, 2010 the Company and BMR agreed to amend the Agreement (the “Amendment”). According to the Amendment, the final payment was modified as follows: the Company will pay Eight Hundred Thousand Dollars ($800,000), as follows: (i) Two Hundred Thousand Dollars ($200,000) within five (5) days after the Execution Date and (ii) One Hundred Thousand Dollars ($100,000) on each of the following dates: July 15, 2010, August 15, 2010, September 15, 2010, October 15, 2010, November 15, 2010, and December 15, 2010. Through November 11, 2010 the Company paid $400,000 of the principal plus $6,000 interest for late payments in accordance with the terms of the Lease Termination Agreement.

We continue to lease office space at 240 Cedar Knolls Road, Cedar Knolls, NJ under a non-cancellable operating lease expiring in 2013.

On April 6, 2007, the Board of Directors appointed Michael V. Novinski to the position of President and Chief Executive Officer. Pursuant to his appointment, the Company has entered into a three year employment agreement with Mr. Novinski. Mr. Novinski’s employment agreement renews automatically in one year increments unless either party notifies the other at least 60 days prior to the date of expiration of their intention to terminate. If Mr. Novinski’s contract is terminated without cause by the Board of Directors or at any time by the executive for good reason as defined in his contract, we are obligated to make severance payments to Mr. Novinski.

opposed Dr. Goldberg’s petition to confirm the arbitration award. On July 12, 2010 the award was confirmed by the court. As of August 10, 2010, the Company adjusted its estimate of costs to settle this matter to approximately $2.6 million to account for potential additional interest costs on the settlement amount and additional legal fees. On September 23, 2010, the Company paid approximately $2.6 million as full and final settlement of this matter.

The Company evaluates the financial consequences of legal actions quarterly or as facts present themselves and books accruals to account for its best estimate of future costs accordingly.

Contingencies.In the ordinary course of business, we enter into agreements with third parties that include indemnification provisions which, in our judgment, are normal and customary for companies in our industry sector. These agreements are typically with business partners, clinical sites, and suppliers. Pursuant to these agreements, we generally agree to indemnify, hold harmless, and reimburse indemnified parties for losses suffered or incurred by the indemnified parties with respect to our product candidates, use of such product candidates, or other actions taken or omitted by us. The maximum potential amount of future payments we could be required to make under these indemnification provisions is unlimited. We have not incurred material costs to defend lawsuits or settle claims related to these indemnification provisions. As a result, the estimated fair value of liabilities relating to these provisions is minimal. Accordingly, we have no liabilities recorded for these provisions as of September 30, 2010.

In the normal course of business, we may be confronted with issues or events that may result in a contingent liability. These generally relate to lawsuits, claims, environmental actions or the action of various regulatory agencies. If necessary, management consults with counsel and other appropriate experts to assess any matters that arise. If, in our opinion, we have incurred a probable loss as set forth by accounting principles generally accepted in the U.S., an estimate is made of the loss and the appropriate accounting entries are reflected in our financial statements. After consultation with legal counsel, we do not anticipate that liabilities arising out of currently pending or threatened lawsuits and claims will have a material adverse effect on our financial position, results of operations or cash flows.

Restructuring Expense

On December 8, 2008, as part of our efforts to improve operational efficiency we decided to close our research and development facilities in Tarrytown to reduce costs and improve operating efficiency which resulted in a restructuring charge of approximately $3.8 million in the fourth quarter, 2008. On April 29, 2009, the Company entered into the Lease Termination Agreement with BMR, and credited the restructuring charge $0.35 million in accordance with the terms of the Agreement. On March 17, 2010 the Company and BMR amended the Agreement as described in this Note (above). Consequently, the restructuring liability was readjusted to reflect the terms of the Amendment accordingly.

Adjustments to the restructuring liability are as follows ($ thousands):


	Liability at		Cash			Adjustment to		Liability at
	December 31, 2009		Payments			the Liability		September 30, 2010
Lease restructuring expense	$	750	$	(350	)	$	50	$	450

13. Income Taxes

The Company is primarily subject to United States federal and New Jersey state income tax. The Company’s policy is to recognize interest and penalties related to income tax matters in income tax expense. As of December 31, 2009 and September 30, 2010, the Company had no accruals for interest or penalties related to income tax matters. For the three months ended September 30, 2010 and 2009, the effective income tax rate was 0%. The difference between the Company’s effective income tax rate and the Federal statutory rate of 35% is attributable to state tax benefits and tax credits offset by changes in the deferred tax valuation allowance.

14. New Accounting Pronouncements

an arrangement using estimated selling prices of the delivered goods and services based on a selling price hierarchy. The amendments eliminate the residual method of revenue allocation and require revenue to be allocated using the relative selling price method. ASU 2009-13 should be applied on a prospective basis for revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with early adoption permitted. The adoption of ASU 2009-13 did not have a material impact on the Company’s results of operations or financial condition.

In April 2010, the FASB issued ASU 2010-17, Revenue Recognition — Milestone Method (“ASU 2010-17”). ASU 2010-17 provides guidance on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. A vendor can recognize consideration that is contingent upon achievement of a milestone in its entirety as revenue in the period in which the milestone is achieved only if the milestone meets all criteria to be considered substantive. The following criteria must be met for a milestone to be considered substantive. The consideration earned by achieving the milestone should (i) be commensurate with either the level of effort required to achieve the milestone or the enhancement of the value of the item delivered as a result of a specific outcome resulting from the vendor’s performance to achieve the milestone; (ii) be related solely to past performance; and (iii) be reasonable relative to all deliverables and payment terms in the arrangement. No bifurcation of an individual milestone is allowed and there can be more than one milestone in an arrangement. Accordingly, an arrangement may contain both substantive and nonsubstantive milestones. ASU 2010-17 is effective on a prospective basis for milestones achieved in fiscal years, and interim periods within those years, beginning on or after June 15, 2010. Management evaluated the potential impact of ASU 2010-17 and does not expect its adoption to have a material effect on the Company’s results of operations or financial condition.

Management does not believe there would have been a material effect on the accompanying financial statements had any other recently issued, but not yet effective, accounting standards been adopted in the current period.

15. Fair Value

In accordance with FASB ASC 820, “Fair Value Measurements and Disclosures,” the following table represents the Company’s fair value hierarchy for its financial assets and liabilities measured at fair value on a recurring basis as of September 30, 2010 and December 31, 2009:


	Level 2		Level 2
	September 30, 2010		December 31, 2009
	($ thousands)		($ thousands)
Derivative instruments (short term)	$	9,900	$	6,189
Derivative instruments (long term)		8,557		4,591

Total	$	18,457	$	10,780

Some of the Company’s financial instruments are not measured at fair value on a recurring basis but are recorded at amounts that approximate fair value due to their liquid or short-term nature, such as cash and cash equivalents, receivables and payables.

We have determined that it is not practical to estimate the fair value of our notes payable because of their unique nature and the costs that would be incurred to obtain an independent valuation. We do not have comparable outstanding debt on which to base an estimated current borrowing rate or other discount rate for purposes of estimating the fair value of the notes payable and we have not been able to develop a valuation model that can be applied consistently in a cost efficient manner. These factors all contribute to the impracticability of estimating the fair value of the notes payable. At September 30, 2010, the carrying value of the notes payable and accrued interest was $15.4 million. The MHR Convertible Notes, which are due on September 26, 2012, yield an effective interest rate of 41.2%. Refer to Note 8 of these financial statements for more information about the Company’s notes payable.

16. Sale of Patents

On February 8, 2008, the Company sold to MannKind Corporation (“MannKind”) certain patents and a patent application relating to diketopiperazine technology for a total purchase price of $2.5 million. An initial payment of

$1.5 million was received in February 2008 and recognized as other income. An additional $0.5 million was paid in May 2009 and the final $0.5 million payment was made September 30, 2010.

ITEM 2. MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

SAFE HARBOR CAUTIONARY STATEMENT

Certain statements in this Management’s Discussion and Analysis of Financial Conditions and Results of Operations and elsewhere in this report as well as statements made from time to time by our representatives may constitute “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. These forward looking statements include (without limitation) statements regarding planned or expected studies and trials of oral formulations that utilize our Eligen^® Technology; the timing of the development and commercialization of our product candidates or potential products that may be developed using our Eligen^® Technology; the potential market size, advantages or therapeutic uses of our potential products; variation in actual savings and operational improvements resulting from restructurings; and the sufficiency of our available capital resources to meet our funding needs. We do not undertake any obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise, except as required by law. Such forward-looking statements involve known and unknown risks, uncertainties and other factors which may cause our actual results, performance or achievements to be materially different from any future results or achievements expressed or implied by such forward-looking statements. Such factors include the factors described under Part II, Item 1A. “Risk Factors” and other factors discussed in connection with any forward looking statements.

General

Emisphere Technologies, Inc. is a biopharmaceutical company that focuses on a unique and improved delivery of therapeutic molecules or nutritional supplements using its Eligen^® Technology. These molecules could be currently available or are under development. In many cases, their benefits are limited due to poor bioavailability or slow on-set of action. In those cases, our technology may increase the benefit of the therapy by improving the absorption process or by decreasing the time to reach the general circulation, decreasing time to onset of action and consequently improving their bioavailability. The Eligen^® Technology can be applied to the oral route of administration as well other delivery pathways, such as buccal, rectal, inhalation, intra-vaginal or transdermal. The Eligen^® Technology can make it possible to orally deliver certain therapeutic molecules without altering their chemical form or biological integrity. Eligen^® delivery agents, or “carriers”, facilitate or enable the transport of therapeutic molecules across the mucous membranes of the gastrointestinal tract, to reach the bloodstream where they can exert their intended pharmacological effect.

Since our inception in 1986, substantial efforts and resources have been devoted to understanding the Eligen^® Technology and establishing a product development pipeline that incorporated this technology with selected molecules. Since 2007, Emisphere has undergone many positive changes. A new senior management team, led by Michael V. Novinski, was hired; the Eligen^® Technology was reevaluated and our corporate strategy was refocused on commercializing the Eligen^® Technology as quickly as possible, building high-value partnerships and reprioritizing the product pipeline. Spending was redirected and aggressive cost control initiatives were implemented. These changes resulted in redeployment of resources to programs, one of which, yielded the introduction of our first commercial product during 2009. We continue to develop potential product candidates in-house and we demonstrated and enhanced the value of the Eligen^® Technology as evident in the progress made by our development partners Novo Nordisk A/S (“Novo Nordisk”) and Novartis Pharma AG (“Novartis”) on their respective product development programs. Further development, exploration and commercialization of the technology entail risk and operational expenses. However, we have made significant progress on refocusing our efforts on strategic development initiatives and cost control and continue to aggressively seek to reduce non-strategic spending.

The application of the Eligen^® Technology is potentially broad and may provide for a number of opportunities across a spectrum of therapeutic areas or nutritional supplements. During the second quarter 2010, we continued to develop our product pipeline utilizing the Eligen^® Technology with prescription, nonprescription and medical food product candidates. We prioritized our development efforts based on overall potential returns on investment, likelihood of success, and market and medical need. Our goal is to implement our Eligen^® Technology to enhance overall healthcare, including patient accessibility and compliance, while benefiting the commercial pharmaceutical marketplace and

driving company valuation. Investments required to continue developing our product pipeline may be partially paid by income-generating license arrangements whose value tends to increase as product candidates move from pre-clinical into clinical development. It is our intention that incremental investments that may be required to fund our research and development will be approached incrementally in order to minimize disruption or dilution.

We plan to attempt to expand our current collaborative relationships to take advantage of the critical knowledge that others have gained by working with our technology. We will also continue to pursue product candidates for internal development and commercialization. We believe that these internal candidates must be capable of development with reasonable investments in an acceptable time period and with a reasonable risk-benefit profile.

Our product pipeline includes prescription, medical foods and nutritional supplements candidates. We reported progress on our planned medical food formulation of oral Eligen^® B12 1000 mcg. for use by B12 deficient individuals. Our recently completed clinical trial showed that oral Eligen^® B12 1000 mcg can efficiently and quickly restore Vitamin B12 levels in deficient individuals as effectively as the injectable formulation which is the current standard of care. During July 2010, we announced that we are engaged in ongoing discussions with potential licensees for our high dose oral Eligen^® B12 1000 mcg as a medical food for individuals with B12 deficiency. In addition, we are evaluating the possibility of marketing the product without a partner. As a medical food, Emisphere’s oral Eligen^® B12 1000 mcg is designed as a specially formulated and processed oral formulation for the specific dietary management of patients under medical supervision who, because of a limited or impaired capacity to absorb Vitamin B12 , have a diagnosed Vitamin B12 deficiency. It is estimated that as many as 10 million people in the U.S. and over 100 million people worldwide may be B12 deficient. Oral Eligen^® B12 and the foregoing statements have not been evaluated by the Food and Drug Administration. Oral Eligen^® B12 is not intended to diagnose, treat, cure, or prevent any disease.

Previously, the Company had announced interim data from the recently completed study demonstrated that its oral Eligen^® B12 1000 mcg given to individuals with low B12 levels restores normal B12 serum concentrations. Normal levels of serum B12 were achieved by all study participants who had taken oral Eligen^® B12 1000 mcg 15 days into the 90-day study when the first blood samples were taken. These data, in Abstract Number 8370, were presented at the Experimental Biology 2010 Conference in Anaheim, California. In this open-label, randomized, 90-day study, serum cobalamin (B12) and holotranscobalamin (active B12) were collected and measured at Baseline, Day 15, Day 31, Day 61 and Day 91. A total of 49 study participants were enrolled (26 on IM injection and 23 on oral) and received either nine 1000 mcg intramuscular injections of Vitamin B12 or once daily tablets of oral Eligen^® B12 1000 mcg. The results from the interim analysis showed that serum cobalamin and active B12 returned to the normal range with both products and normalization was maintained. With participants in the oral Eligen^® B12 1000 mcg group showing the ability to rapidly achieve normalized serum and active B12 levels, the study illustrates the potential of the Eligen^® Technology and of the high dose, oral Eligen^® B12 1000 mcg formulation to offer a much needed medical food alternative to painful and inconvenient IM injections.

In the development of prescription products, our licensees include Novartis, which is using our Eligen^® drug delivery technology in combination with salmon calcitonin, parathyroid hormone, and human growth hormone; and Novo Nordisk which is using the Eligen^® Technology in combination with its proprietary GLP-1 receptor agonists.

During June 2010, we announced that we entered into an expanded relationship with Novartis pursuant to which Novartis has cancelled the Company’s Convertible Promissory Note (the “Novartis Note”). The Novartis Note was originally issued to Novartis on December 1, 2004 in connection with the Research Collaboration and Option License Agreement between the parties of that date and was originally due December 1, 2009. Previously, Novartis had agreed to extend the maturity date to June 4, 2010. In connection with the cancellation of the Novartis Note, the parties agreed to modify the royalty and milestone payment schedule for the Research Collaboration and Option Agreement and License Agreement between the parties for the development of an oral salmon calcitonin product for the treatment of osteoarthritis and osteoporosis. Additionally, we have granted Novartis the right to evaluate the feasibility of using Emisphere’s Eligen^® Technology with two new compounds to assess the potential for new product development opportunities. If Novartis chooses to develop oral formulations of these new compounds using the Eligen^® Technology, the parties will negotiate additional agreements. In that case, Emisphere could be entitled to receive development milestone and royalty payments in connection with the development and commercialization of these potentially new products.

Novartis’ most advanced program is testing an oral formulation of calcitonin to treat osteoarthritis and osteoporosis. Novartis is conducting two Phase III clinical studies for osteoarthritis and one Phase III clinical study for osteoporosis. Now that these Phase III studies are fully enrolled, over 5,500 clinical study patients used the Eligen^® Technology during 2009 and continue to use it during 2010. During October we announced that Novartis Pharma AG (“Novartis”) provided us with information regarding the first interpretable results of the two-year Phase III Study 2301 in osteoarthritis conducted by its license partner Nordic Bioscience with oral calcitonin. The recently completed study assesses the safety and efficacy of oral calcitonin in the treatment of osteoarthritis of the knee and had three co-primary endpoints. Novartis informed Emisphere that preliminary analysis of the data from this study shows that the endpoint for the first of three co-primary endpoints, joint space width narrowing, was not met. Novartis also informed Emisphere that results regarding the other two co-primary endpoints indicated clinical efficacy related to symptom modification (WOMAC scales: pain, function). In addition, according to Novartis, MRI analyses suggested an effect on cartilage. Nordic Bioscience and Novartis have indicated that they are going to continue to work together to further analyze and evaluate the results of this study. The second two-year Phase III Study 2302, which also assesses safety and efficacy of oral calcitonin of patients with osteoarthritis of the knee, is currently ongoing. Additionally, the Phase III clinical program of oral calcitonin in osteoporosis continues.

During July 2010, we announced that Novartis Pharma AG and its license partner Nordic Bioscience a/s (the “Sponsor”) reported the following in connection with their Phase III Study 2302 in osteoarthritis assessing the safety and efficacy of oral calcitonin in the treatment of osteoarthritis of the knee. This study incorporates Emisphere’s unique and proprietary Eligen^® Drug Delivery Technology for the improved oral absorption of salmon calcitonin. An independent Data Monitoring Committee (“DMC”) conducted a futility analysis of one-year data for all patients enrolled in this two-year study, including assessments of safety and efficacy parameters. The DMC concluded that although there is no reason to stop Study 2302 because of safety concerns, there is no reason to continue the study for efficacy. The DMC also concluded that the final decision whether to continue Study 2302 rests with the Sponsor. A parallel two-year Phase III Study 2301 in osteoarthritis assessing the safety and efficacy of oral calcitonin in the treatment of osteoarthritis of the knee is still in progress. In December 2009, the DMC conducted a futility analysis of one-year data for all patients enrolled in this two-year study, including assessments of safety and efficacy parameters, and recommended to continue with such Study. The Sponsor currently intends to continue the clinical program of oral calcitonin in osteoarthritis, including both Phase III Study 2301 and Phase III Study 2302. Novartis and Nordic Bioscience will continue to work together to assess next steps once the final data of Study 2301 is available. This data is expected to be available in the fourth quarter, 2010. Additionally, the Sponsor currently intends to continue the clinical program of oral calcitonin in osteoporosis. Previously, in its quarterly earnings report for the period ended June 30, 2010, Novartis stated that oral calcitonin for the treatment of osteoporosis is planned to file with the regulatory authorities during 2011.

During April 2010, we announced the publication of a research study entitled, “Investigation of the Direct Effect of Salmon Calcitonin on Human Osteoarthritic Chondrocytes,” by Nordic Bioscience in the April 5, 2010 edition of the publicationBMC Musculoskeletal Disorders. Oral salmon calcitonin, which uses Emisphere’s proprietary Eligen^® Technology, is currently being studied in osteoarthritis and osteoporosis by Novartis Pharma AG and Nordic Bioscience. The study was conducted in vitro on cartilage samples obtained from female patients undergoing total knee arthroplasty surgery for the treatment of osteoarthritis. The article describes the growth promoting effects of salmon calcitonin on these cartilage samples. The study shows that treatment with pharmacological concentrations of calcitonin increases synthesis of both proteoglycan (proteins and sugars which interweave with collagen) and collagen type II — the key components of articular cartilage. This research is unique and significant as it represents the first work to look chiefly at the ability of salmon calcitonin to stimulate cartilage synthesis. These findings provide evidence to substantiate the theory that calcitonin may exert a positive effect on joint health through its dual action of promoting both bone and cartilage formation.

During December 2009, we announced a meta-analysis published in the December 2009 edition ofRheumatology Reportsexamining independent evidence of the analgesic action of the hormone calcitonin. This publication restated the potential of calcitonin in filling a significant unmet need for alternative treatments for persistent musculoskeletal pain. Scientists from Nordic Bioscience were involved in the preparation of this meta-analysis. Non-malignant musculoskeletal pain is the most common clinical symptom that causes patients to seek medical attention and is a

major cause of disability in the world. Musculoskeletal pain can arise from a variety of common conditions including osteoarthritis, rheumatoid arthritis, osteoporosis, surgery, low back pain and bone fracture. The meta-analysis, conducted by researchers at the Center for Sensory-Motor Interaction in the Department of Health Science and Technology at Aalborg University in Denmark, examined independent pre-clinical and clinical studies spanning nearly 45 years of the possible intrinsic analgesic properties of calcitonin, with special focus on the challenges in the musculoskeletal system. The authors concluded that well-designed clinical trials should be conducted to further validate evidence of calcitonin’s analgesic action and its promising potential role in the management of musculoskeletal pain. The effects of calcitonin on clinical pain conditions have received increasing attention in the past decades, although a consensus on mechanism-of-action and potential indications has not been reached. The analgesic activity of oral salmon calcitonin has been shown in several controlled prospective double-blind studies; besides pain management in osteoporosis, calcitonin has shown analgesic action in painful conditions such as phantom limb pain, diabetic neuropathy, complex regional pain syndrome, adhesive capsulitis, rheumatoid arthritis, vertebral crush fractures, spondylitis, tumor metastasis, cancer pain, migraine, Paget’s disease of bone as well as post-operative pain. An ideal treatment with an optimal efficacy, safety and convenience profile is not available for the musculoskeletal pain associated with such conditions as osteoporosis and osteoarthritis. This review of the literature highlights the clear unmet medical need that could be addressed by Emisphere’s oral salmon calcitonin product.

Novartis is also engaged in research using the Eligen^® Technology and PTH-1-34 to develop a safe and effective oral formulation of PTH for the treatment of postmenopausal osteoporosis, PTH is produced by the parathyroid glands to regulate the amount of calcium and phosphorus in the body. When used therapeutically, it increases bone density and bone strength to help prevent fractures. It is approved to treat osteoporosis, a disease associated with a gradual thinning and weakening of the bones that occurs most frequently in women after menopause. Untreated postmenopausal osteoporosis can lead to chronic back pain, disabling fractures, and lost mobility. Novartis conducted a Phase I study in postmenopausal women to determine the safety and tolerability of oral PTH-1-34, a combination of human PTH-1-34 and Emisphere’s delivery agent 5-CNAC, for the treatment of postmenopausal osteoporosis. The study was designed to assess the bioavailability profile of increasing doses of PTH-1-34 combined with different amounts of 5-CNAC administered orally. The results, from the single-center, partially-blinded, incomplete cross-over study were presented October 19, 2009 in a poster session at the 73rd Annual Scientific Meeting of the American College of Rheumatology in Philadelphia, PA. Study results demonstrated that a single dose of the novel oral parathyroid hormone PTH-1-34, which utilizes Emisphere’s proprietary Eligen^® Drug Delivery Technology and absorption-enhancing carrier molecule 5-CNAC, achieved potentially therapeutically relevant exposure and safety profiles similar to those of the currently available injectable formulation in healthy postmenopausal women.

During April 2010, we announced that Novartis Pharma AG initiated a second Phase I trial for an oral PTH-1-34 which uses Emisphere’s Eligen^® Technology, and is in development for the treatment of postmenopausal osteoporosis. The study is a partially blinded, placebo controlled, active comparator study to explore the safety, tolerability, pharmacokinetics and pharmacodynamics in postmenopausal women after daily oral doses of PTH-1-34. The study has two parts (A and B) and will enroll a total of approximately up to 120 postmenopausal women. In Part A of the trial, ascending doses of oral PTH-1-34 using the Eligen^® Technology will be tested for safety, tolerability and pharmacokinetics and compared to Forsteo^®. In Part B, in addition to safety and tolerability of oral PTH-1-34 using the Eligen^® Technology, pharmacodynamic responses will be measured by bone biomarker levels and bone mineral density, and compared to Forsteo^®. The first patient was enrolled in April, 2010.

Research using the Eligen^® Technology and GLP-1, a potential treatment for Type 2 Diabetes is being conducted by Novo Nordisk and by Professor Christoph Beglinger, M.D., of the Clinical Research Center, Department of Biomedicine Division of Gastroenterology, and Department of Clinical Pharmacology and Toxicology at University Hospital in Basel, Switzerland. We had previously conducted extensive tests on oral insulin for Type 1 Diabetes and concluded that a more productive pathway is to move forward with GLP-1 and its analogs, an oral form of which might be used to treat Type 2 Diabetes and related conditions. Consequently, on June 21, 2008 we entered into an exclusive Development and License Agreement with Novo Nordisk focused on the development of oral formulations of Novo Nordisk’s proprietary GLP-1 receptor agonists.

During January 2010, we announced that Novo Nordisk had initiated its first Phase I clinical trial with a long-acting oral GLP-1 analogue (NN9924). This milestone released a $2 million payment to Emisphere, whose proprietary

Eligen^® Technology is used in the formulation of NN9924. GLP-1 (Glucagon-Like Peptide-1) is a natural hormone involved in controlling blood sugar levels. It stimulates the release of insulin only when blood sugar levels become too high. GLP-1 secretion is often impaired in people with Type 2 Diabetes. The aim of this trial, which is being conducted in the UK, is to investigate the safety, tolerability and bioavailability of NN9924 in healthy volunteers. The trial will enroll approximately 155 individuals and results from the trial are expected in 2011. There are many challenges in developing an oral formulation of GLP-1, in particular obtaining adequate bioavailability. NN9924 addresses some of these key challenges by utilizing Emisphere’s Eligen^® Technology to facilitate absorption from the gastrointestinal tract.

Professor Beglinger is also conducting research assessing the feasibility of using the Eligen^® Technology combined with PYY3-36 and native GLP-1, as a potential treatment for obesity. During September 2010 we announced that a clinical study conducted by Professor Beglinger found that the Company’s proprietary oral SNAC (Sodium N-[8-(2-hydroxybenzoyl) Amino] Caprylate (“SNAC”), in combination with two digestive hormones, was successful in reducing food intake and increasing satiety in healthy male subjects. The study was published in the August 18, 2010 online edition of theAmerican Journal of Clinical Nutrition, the official publication of the American Society for Nutrition. As described in the publication, 12 healthy male subjects were studied in a randomized double-blind, placebo-controlled 4-way crossover trial. Each subject received (in random order) 2.0 mg native GLP-1, 1.0 mg PYY3-36, or 2.0 mg native GLP-1, plus 1.0 mg PYY3-36. Researchers observed that both digestive hormones, native GLP-1 and PYY3-36, were rapidly absorbed from the gut, leading to plasma concentrations several times higher than those in response to a normal meal. native GLP-1 alone, but not PYY3-36, significantly reduced total food intake. Co-administration of both hormones, taken in combination with SNAC in a single oral dose, reduced both total food intake by 21.5 percent, and increased fullness at meal onset (P <0.05). The 24-hour food intake was not affected by the single oral administration of the native hormones likely due to their short half-life. The two digestive hormones utilized in the study are released naturally in proportion to ingested calories and signal “satiety,” or fullness, to the brain. SNAC, which is based on Emisphere’s Eligen^® Technology, facilitates transport of these and other hormones with low oral bioavailability across biological membranes, such as those of the gastrointestinal tract. Emisphere had previously announced that SNAC had achieved Generally Recognized as Safe (“GRAS”) status for its intended use in combination with nutrients added to food and dietary supplements.

During May 2009 the Company announced data from another clinical study conducted by Professor Beglinger designed to assess the effect of oral administration of two peptides, native GLP-1 and PYY3-36, utilizing Emisphere’s Eligen^® Technology on appetite suppression. The randomized, double-blind, placebo-controlled trial was conducted in 16 normal weight males between the ages of 18 and 40. The study was designed to investigate the effects of orally administered native GLP-1 and PYY3-36 formulated with Emisphere’s Sodium N-[8-(2-hydroxybenzoyl) Amino] Caprylate (“SNAC”) carrier and their potential effect in the control of food intake and satiety. Prior studies have shown the ability of both peptides to reduce appetite and food consumption in healthy subjects and in patients with obesity. The study concluded that these orally administered peptides, when delivered with Emisphere’s SNAC carrier, were rapidly absorbed from the gastrointestinal tract, leading to concentrations several times higher than endogenous hormone levels achieved after a standard test meal. Specifically, results showed that oral native GLP-1 (2 mg tablet) alone and the combination of oral native GLP-1 (2 mg tablet) plus PYY3-36 (1 mg tablet) induced a significant reduction in calorie intake although there was no synergistic effect when the two peptides were used in combination. Oral PYY3-36 at a 1 mg dose by itself did not significantly reduce calorie intake. Oral native GLP-1 (2 mg tablet) and oral PYY3-36 (1 mg tablet) were both shown to induce a rapid increase in plasma native GLP-1 concentrations and plasma PYY concentrations, respectively. This new data represents further evidence of the ability of the Eligen^® Technology, and the SNAC carrier, to enhance oral absorption of peptides which normally exhibit low oral bioavailability. In this case, native GLP-1 alone, and the combination of the two peptides together, were able to cross the gastrointestinal tract into the bloodstream in high enough concentrations to significantly affect appetite.

In October 2008, Professor Beglinger published the results of another study assessing the oral delivery of native GLP-1 and PYY3-36 using Emisphere’s proprietary delivery technology. The study was conducted at University Hospital in Basel, Switzerland and showed, for the first time, that satiety peptides such as native GLP-1 and PYY3-36 can be delivered orally in humans with safety and efficiency. The study, conducted in 12 healthy subjects, was designed to establish the pharmacokinetics and pharmacodynamics of increasing oral doses of native GLP-1 and PYY3-36. Emisphere’s delivery agent, known as SNAC, was formulated as a tablet with native GLP-1 or PYY3-36.

Both oral native GLP-1 and PYY3-36 induce rapid and dose-dependent increases in plasma drug concentrations; native GLP-1 induces a relevant insulin release; and, both peptides suppressed ghrelin secretion in healthy male volunteers. This clinical study of the compound confirms Professor Beglinger’s earlier results that SNAC allows for rapid oral absorption of native GLP-1 or PYY3-36. The study results were published in the October 2008 issue ofClinical Pharmacology & Therapeutics.

Our other product candidates in development are in earlier or preclinical research phases, and we continue to assess them for their compatibility with our technology and market need. Our intent is to seek partnerships with pharmaceutical and biotechnology companies for certain of these products. We plan to expand our pipeline with product candidates that demonstrate significant opportunities for growth. During March 2010, Emisphere and Alchemia Ltd. (ASX: ACL) announced that they would join efforts to develop an oral formulation of the anti-coagulant drug fondaparinux with Emisphere’s Eligen^® Technology. Fondaparinux, an anti-coagulant used for the prevention of deep vein thrombosis, is marketed in injectable form as Arixtra^® by GlaxoSmithKline. Arixtra^® has been off patent since 2002 but, due to the complexity of its synthesis, there is currently no approved generic or alternative source of commercial scale active pharmaceutical ingredient (“API”). Alchemia has developed a novel, patent protected, synthesis for the manufacture of fondaparinux at commercial scale. In March 2009, Alchemia’s manufacturing and U.S. marketing partner, Dr Reddy’s Laboratories (NYSE: RDY) submitted an ANDA to the U.S. FDA for a generic version of the injectable form of fondaparinux. We believe an oral formulation of fondaparinux could dramatically increase the market potential for fondaparinux. Based on what we know from our experience with other chemically-related anti-coagulants, the profile of fondaparinux should fit very well with the Eligen^® Technology given its half life and safety profile. Although developing an oral formulation of an injectable compound is always challenging, this project could produce substantial benefits for the medical community. The combination of Emisphere’s delivery technology and Alchemia’s fondaparinux may ultimately allow us to bring an oral anti-coagulant to market in an accelerated fashion. Alchemia has already seen preclinical data suggesting that enhanced levels of oral absorption can be achieved for fondaparinux. If the dose formulated with the Eligen^® Technology can be successfully optimized, it could open up a host of medically and commercially compelling opportunities for fondaparinux, Alchemia plans to evaluate a number of different formulations initially in order to optimize oral bioavailability and pharmacokinetics, with the aim of then rapidly moving into human clinical studies.

By expanding our relationship with Novartis and settling the Novartis Note on non-dilutive terms (see Note 8 to the Financial Statements contained in this quarterly report) the Company strengthened its Balance Sheet and enhanced the potential future value of its Eligen^® Technology through the potential future additional development and commercialization of potentially new products by Novartis. By focusing on improving operational efficiency, we have strengthened our financial foundation while maintaining our focus on advancing and commercializing the Eligen^® Technology. By closing our research and development facility in Tarrytown, NY and utilizing independent contractors to conduct essential research and development, we reduced our annual cash burn from operating activities to approximately $8 million per year. Additionally, we have accelerated the commercialization of the Eligen^® Technology in a cost effective way and gained operational efficiencies by tapping into more advanced scientific processes independent contractors can provide.

Results of Operations

Three Months Ended September 30, 2010 Compared to Three Months Ended September 30, 2009:


				Three Months Ended
				September 30,
	2010			2009			Change
	(in thousands)
Revenue	$	4		$	—		$	4
Operating expenses	$	3,879		$	3,393		$	486
Operating loss	$	(3,875	)	$	(3,393	)	$	(482	)
Other income (expense)	$	13,522		$	(644	)	$	14,166
Net income (loss)	$	9,647		$	(4,037	)	$	13,684

Revenue increased $4 thousand for the three months ended September 30, 2010 compared to the same period last year due to the receipt of $4 thousand in connection with the oral fondaparinux feasibility study.

Operating expenses increased $0.49 million or 14% for the three months ended September 30, 2010 in comparison to the same period last year. Details of these changes are highlighted in the table below:


	(in thousands)
Decrease in human resources costs	$	(178	)
Increase in professional fees		454
Increase in occupancy costs		1
Decrease in clinical costs		(152	)
Decrease in depreciation and amortization		(46	)
Increase in other costs		407

	$	486

Human resource costs decreased $178 thousand, or 14%, due primarily to a $155 thousand reduction in non-cash compensation, and a $23 thousand decrease from a reduction in personnel in 2010.

Professional fees increased $454 thousand, or 39%, due primarily to a $415 thousand increase in legal fees in connection with commercial development efforts and the Novartis Note cancellation and a $39 thousand increase in other professional fees.

Occupancy costs increased $1 thousand, or 1%, due to higher common area maintenance costs.

Clinical costs decreased $152 thousand, or 35%, due primarily to a decrease in clinical trial costs related to B-12 as the trial nears completion.

Depreciation and amortization costs decreased $46 thousand, or 38%, due to the write off of certain equipment in connection with the closure of the Tarrytown, NY facility.

Other costs increased $406 thousand, or 115%, due primarily to the $542 thousand charge in connection with the termination of our Distributor Agreement for the marketing, distribution and sale of 100 mcg. Eligen^® B12 with Quality Vitamins and Supplements, Inc., partially offset by a $113 thousand decrease in settlement costs in connection with the arbitration with the Company’s former CEO, and a $23 thousand reduction in expenses associated with the abandonment of the Tarrytown, NY facility during 2009.

Our principal operating costs include the following items as a percentage of total operating expenses:


	Three Months Ended
	September 30,
	2010			2009
Human resource costs, including benefits		27	%		36	%
Professional fees for legal, intellectual property, accounting and consulting		42	%		34	%
Occupancy for our laboratory and operating space		2	%		3	%
Clinical costs		7	%		13	%
Depreciation and amortization		2	%		4	%
Other		20	%		10	%

Other income (expense) increased $14.2 million for the three months ended September 30, 2010 in comparison to the same period last year primarily due to a $14.0 million decrease in the fair value of derivative instruments caused by relative changes in stock price during the three months ended September 30, 2010 compared to the three month period ended September 30, 2009; and an increase of $0.5 million in other income due to the receipt of the final installment payment on the sale of a patent to MannKind offset by an increase of $0.3 million in interest expense.

As a result of the above factors, we had a net income of $9.6 million for the three months ended September 30, 2010, compared to a net loss of $4.0 million for the three months ended September 30, 2009.

Nine Months Ended September 30, 2010 Compared to Nine Months Ended September 30, 2009:


	Nine Months Ended
	September 30,
	2010			2009			Change
	(in thousands)
Revenue	$	55		$	—		$	55
Operating expenses	$	10,055		$	11,050		$	(995	)
Operating loss	$	(10,000	)	$	(11,050	)	$	1,050
Other income (expense)	$	(12,523	)	$	(2,591	)	$	(9,932	)
Net loss	$	(22,523	)	$	(13,641	)	$	(8,882	)

Revenue increased $55 thousand for the nine months ended September 30, 2010 compared to the same period last year due primarily to commercial sales of low dose Eligen^® B-12.

Operating expenses decreased $1.0 million or 9% for the nine months ended September 30, 2010 in comparison to the same period last year. Details of these changes are highlighted in the table below:


	(in thousands)
Decrease in human resources costs	$	(553	)
Decrease in professional fees		(454	)
Decrease in occupancy costs		(821	)
Decrease in clinical costs		(673	)
Decrease in depreciation and amortization		(203	)
Increase in other costs		1,711

	$	(995	)

Human resource costs decreased $553 thousand, or 13%, due primarily to a $615 thousand decrease in non-cash compensation and a $87 thousand decrease from reduction in personnel, offset by the a $150 thousand special bonus award to the Company’s CEO .

Professional fees decreased $454 thousand, or 11%, due primarily to a $177 thousand net decrease in legal fees consisting of a $1.1 million decrease in connection with the completion of the arbitration with the Company’s former CEO offset by a $923 thousand increase in connection with commercial development efforts and general corporate legal support; a $158 thousand decrease in consulting costs and $119 thousand decrease from other professional fees.

Occupancy costs decreased $821 thousand, or 76%, due to the closure of our laboratory facilities in Tarrytown, NY.

Clinical costs decreased $673 thousand, or 50%, due primarily to a $420 thousand decrease in B-12 clinical trial costs as the trial nears completion; a $194 thousand decrease in connection with costs incurred to close the laboratory facilities in Tarrytown, NY in 2009; and a $59 thousand decrease in materials production costs.

Depreciation and amortization costs decreased $203 thousand, or 48%, due to the sales of laboratory equipment and the write off of certain equipment in connection with the closure of the Tarrytown, NY facility.

Other costs increased $1.7 million, or 542%, due primarily to the receipt of $823 thousand proceeds from the sale of fixed asset equipment in 2009, a $542 thousand charge incurred during the third quarter 2010 in connection with the termination of our Distributor Agreement with Quality Vitamins and Supplements, Inc., an increase of $82 thousand settlement costs in connection with the arbitration with the Company’s former CEO,, and a net $263 thousand increase related to the closure of the Tarrytown, NY facility in 2009.

Our principal operating costs include the following items as a percentage of total operating expenses:


	Nine Months Ended
	September 30,
	2010			2009
Human resource costs, including benefits		38	%		39	%
Professional fees for legal, intellectual property, accounting and consulting		37	%		38	%
Occupancy for our laboratory and operating space		2	%		10	%
Clinical costs		7	%		12	%
Depreciation and amortization		2	%		4	%
Other		14	%		-3	%

Other expense increased $9.9 million for the nine months ended September 30, 2010 in comparison to the same period last year primarily due to a $8.3 million increase in the fair value of derivative instruments due to the issuance of new warrants and to relative changes in stock price during the nine months ended September 30, 2010 and September 30, 2009 respectively; an increase of $1.3 million in interest expense and a decrease of $0.2 million in sublease income in connection with the closure of our Tarrytown, NY facility during 2009.

As a result of the above factors, we had a net loss of $22.5 million for the nine months ended September 30, 2010, compared to a net loss of $13.6 million for the nine months ended September 30, 2009.

Liquidity and Capital Resources

Since our inception in 1986, we have generated significant losses from operations and we anticipate that we will continue to generate significant losses from operations for the foreseeable future. As of September 30, 2010, our accumulated deficit was approximately $459.2 million and our stockholders deficit was approximately $60.9 million. Our net income and operating loss was $9.6 million and $3.9 million, respectively for the three months ended September 30, 2010 compared to a net loss and net operating loss of $4.0 million and $3.4 million, respectively for the three months ended September 30, 2009. Our net loss and net operating loss for the nine months ended September 30, 2010 were $22.5 million and $10.0 million, respectively, compared to $13.6 million and $11.1 million, respectively, for the nine months ended September 30, 2009.

On August 25, 2010, the Company entered into a securities purchase agreement (together with the securities purchase agreement with MHR and its affiliates, as described below, the “August 2010 Financing”) with certain institutional investors pursuant to which the Company agreed to sell an aggregate of 3,497,528 shares of its common stock and warrants to purchase a total of 2,623,146 additional shares of its common stock for total gross proceeds of $3,532,503.28. Each unit, consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock, was sold at a purchase price of $1.01. The warrants to purchase additional shares are exercisable at a price of $1.26 per share and will expire 5 years from the date of issuance. In accordance with the terms of a registration rights agreement with the investors, the Company filed a registration statement on September 15, 2010, which was declared effective October 12, 2010. On August 25, 2010, the Company also announced that it had entered into a separate securities purchase agreement with MHR Fund Management LLC (together with its affiliates, “MHR”) as part of the August 2010 Financing, pursuant to which the Company agreed to sell an aggregate of 3,497,528 shares of its common stock and warrants to purchase a total of 2,623,146 additional shares of its common stock for total gross proceeds of $3,532,503.28. Each unit, consisting of one share of common stock and a warrant to purchase 0.75 shares of common stock, was sold at a purchase price of $1.01. The warrants to purchase additional shares are exercisable at a price of $1.26 per share and will expire 5 years from the date of issuance.

On July 29, 2010, we issued a promissory note (the “July 2010 MHR Note”) to MHR in the principal amount of $525,000. The July 2010 MHR Note provided for an interest rate of 15% per annum, with the entire principal amount due and payable on October 27, 2010 (the “Maturity Date”). The July 2010 MHR Note also provided that the Maturity Date would be accelerated, in certain circumstances, to the date that is two business days following the receipt by the Issuer of at least $1,000,000 aggregate cash proceeds from third parties, whether in connection with certain financing transactions, commercial transactions or otherwise. Pursuant to the terms of the July 2010 MHR Note, the August 2010 Financing (described in the previous paragraph) triggered the provision under which the Maturity Date was accelerated and the July 2010 MHR Note was paid during the quarter ended September 30, 2010.

In April 2005, the Company entered into an amended and restated employment agreement with its then Chief Executive Officer, Dr. Michael M. Goldberg, for services through July 31, 2007. On January 16, 2007, the Board of Directors terminated Dr. Goldberg’s services. On April 26, 2007, the Board of Directors held a special hearing at which it determined that Dr. Goldberg’s termination was for cause. On March 22, 2007, Dr. Goldberg, through his counsel, filed a demand for arbitration asserting that his termination was without cause and seeking $1,048,000 plus attorney’s fees, interest, arbitration costs and other relief alleged to be owed to him in connection with his employment agreement with the Company. During the arbitration, Dr. Goldberg sought a total damage amount of at least $9,223,646 plus interest. On February 11, 2010, the arbitrator issued the final award in favor of Dr. Goldberg for a total amount of approximately $2,333,115 plus interest and fees relating to confirmation of the award. The Company opposed Dr. Goldberg’s petition to confirm the arbitration award. On July 12, 2010 the award was confirmed by the court. As of August 10, 2010, the Company adjusted its estimate of costs to settle this matter to approximately $2.6 million to account for potential additional interest costs on the settlement amount and additional legal fees. On September 23, 2010, the Company paid approximately $2.6 million as full and final settlement of this matter.

We anticipate that we will continue to generate significant losses from operations for the foreseeable future, and that our business will require substantial additional investment that we have not yet secured. As such, we anticipate that our existing cash resources will enable us to continue operations through approximately December 2010 or earlier if unforeseen events arise that negatively affect our liquidity. Further, we have significant future commitments and

obligations. These conditions raise substantial doubt about our ability to continue as a going concern. Consequently, the audit opinion issued by our independent registered public accounting firm relating to our financial statements for the year ended December 31, 2009 contained a going concern explanatory paragraph.

Our plan is to raise capital when needed and/or to pursue product partnering opportunities. We expect to continue to spend substantial amounts on research and development, including amounts spent on conducting clinical trials for our product candidates. Expenses will be partially offset with income-generating license agreements or operating revenue, if possible. Further, we will not have sufficient resources to fully develop any new products or technologies unless we are able to raise substantial additional financing on acceptable terms or secure funds from new or existing partners. We cannot assure that financing will be available when needed, or on favorable terms or at all. If additional capital is raised through the sale of equity or convertible debt securities, the issuance of such securities would result in dilution to our existing stockholders. Our failure to raise capital before December 31, 2010 will adversely affect our business, financial condition and results of operations, and could force us to reduce or cease our operations. No adjustment has been made in the accompanying financial statements to the carrying amount and classification of recorded assets and liabilities should we be unable to continue operations. However, we have implemented aggressive cost control initiatives and management processes to extend our cash runway. The Company realized a critical milestone in its cost control plan which will contribute to meeting its cash burn target of between $7 and $8 million per year. We are also pursing new as well as enhanced collaborations and exploring other financing options, with the objective of minimizing dilution and disruption.

Off-Balance Sheet Arrangements

As of September 30, 2010, we had no off-balance sheet arrangements, other than operating leases. There were no changes in significant contractual obligations during the three months ended September 30, 2010.

Critical Accounting Estimates

Please refer to the Company’s Annual Report on Form 10-K filed with the SEC on March 25, 2010 for detailed explanations of its critical accounting estimates which have not changed significantly during the period ended September 30, 2010.

New Accounting Pronouncements

In October 2009, the FASB issued ASU 2009-13,Multiple-Deliverable Revenue Arrangements, (amendments to FASB ASC Topic 605,Revenue Recognition) (“ASU 2009-13”). ASU 2009-13 requires entities to allocate revenue in an arrangement using estimated selling prices of the delivered goods and services based on a selling price hierarchy. The amendments eliminate the residual method of revenue allocation and require revenue to be allocated using the relative selling price method. ASU 2009-13 should be applied on a prospective basis for revenue arrangements entered into or materially modified in fiscal years beginning on or after June 15, 2010, with early adoption permitted. The adoption of ASU 2009-13 did not have a material impact on the Company’s results of operations or financial condition.

In April 2010, the FASB issue ASU 2010-17, Revenue Recognition — Milestone Method (“ASU 2010-17”). ASU 2010-17 provides guidance on the criteria that should be met for determining whether the milestone method of revenue recognition is appropriate. A vendor can recognize consideration that is contingent upon achievement of a milestone in its entirety as revenue in the period in which the milestone is achieved only if the milestone meets all criteria to be considered substantive. The following criteria must be met for a milestone to be considered substantive. The consideration earned by achieving the milestone should (i) Be commensurate with either the level of effort required to achieve the milestone or the enhancement of the value of the item delivered as a result of a specific outcome resulting from the vendor’s performance to achieve the milestone. (ii) Related solely to past performance. (iii) Be reasonable relative to all deliverables and payment terms in the arrangement. No bifurcation of an individual milestone is allowed and there can be more than one milestone in an arrangement. Accordingly, an arrangement may contain both substantive and nonsubstantive milestones. ASU 2010-17 is effective on a prospective basis for milestones achieved

in fiscal years, and interim periods within those years, beginning on or after June 15, 2010. The adoptions of ASU 2010-17 did not have a material impact on the Company’s results of operations or financial condition.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

Fair Value of Warrants and Derivative Liabilities.At September 30, 2010, the estimated fair value of derivative instruments was $18.5 million. We estimate the fair values of these instruments using the Black-Scholes option pricing model which takes into account a variety of factors, including historical stock price volatility, risk-free interest rates, remaining maturity and the closing price of our common stock. We believe that the assumption that has the greatest impact on the determination of fair value is the closing price of our common stock. The following table illustrates the potential effect of changes in the assumptions used to calculate fair value:


	Derivatives
	(in thousands)
25% increase in stock price	$	5,199
50% increase in stock price		10,488
5% increase in assumed volatility		561
25% decrease in stock price		(5,083	)
50% decrease in stock price		(9,990	)
5% decrease in assumed volatility		(585	)

ITEM 4T. CONTROLS AND PROCEDURES

Evaluation of Disclosure Controls and Procedures

The Company’s senior management is responsible for establishing and maintaining a system of disclosure controls and procedures (as defined in Rule 13a-15 and 15d-15 under the Securities Exchange Act of 1934 (the “Exchange Act”)) designed to ensure that information required to be disclosed by the Company in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported within the time periods specified in the Securities and Exchange Commission’s rules and forms. Disclosure controls and procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by an issuer in the reports that it files or submits under the Exchange Act is accumulated and communicated to the issuer’s management, including its principal executive officer or officers and principal financial officer or officers, or persons performing similar functions, as appropriate to allow timely decisions regarding required disclosure.

The Company has evaluated the effectiveness of the design and operation of its disclosure controls and procedures under the supervision of and with the participation of management, including the Chief Executive Officer and Chief Financial Officer, as of the end of the period covered by this report. Based on that evaluation, our Chief Executive Officer and Chief Financial Officer have concluded that our disclosure controls and procedures are effective.

Changes in Internal Control over Financial Reporting

There have been no changes in our internal control over financial reporting during the three month period ended September 30, 2010 that materially affected, or are reasonably likely to materially affect, our internal control over financial reporting.

PART II

ITEM 1. LEGAL PROCEEDINGS

In April 2005, the Company entered into an amended and restated employment agreement with its then Chief Executive Officer, Dr. Michael M. Goldberg, for services through July 31, 2007. On January 16, 2007, the Board of Directors terminated Dr. Goldberg’s services. On April 26, 2007, the Board of Directors held a special hearing at which it determined that Dr. Goldberg’s termination was for cause. On March 22, 2007, Dr. Goldberg, through his counsel, filed a demand for arbitration asserting that his termination was without cause and seeking $1.05 million plus attorney’s fees, interest, arbitration costs and other relief alleged to be owed to him in connection with his employment agreement with the Company. During the arbitration, Dr. Goldberg sought a total damage amount of at least $9.2 million plus interest. On February 11, 2010, the arbitrator issued the final award in favor of Dr. Goldberg for a total amount of approximately $2.3 million plus interest and fees relating to confirmation of the award. The Company opposed Dr. Goldberg’s petition to confirm the arbitration award. On July 12, 2010 the award was confirmed by the court. As of August 10, 2010, the Company adjusted its estimate of costs to settle this matter to approximately $2.6 million to account for potential additional interest costs on the settlement amount and additional legal fees. On September 23, 2010, the Company paid approximately $2.6 million as full and final settlement of this matter.

ITEM 1A. RISK FACTORS

The following risk factors should be read carefully in connection with evaluating our business and the forward-looking statements that we make in this Report and elsewhere (including oral statements) from time to time. Any of the following risks could materially and adversely affect our business, our operating results, our financial condition and the actual outcome of matters as to which forward-looking statements are made in this Report. Our business is subject to many risks, which are detailed further in our Annual Report on Form 10-K, including:

Financial Risks

	•		We have a history of operating losses and we may never achieve profitability. If we continue to incur losses or we fail to raise additional capital or receive substantial cash inflows from our partners by December 2010, we may be forced to cease operations.

			As of September 30, 2010, we had approximately $3.2 million in cash and restricted cash, approximately $11.4 million in working capital deficiency, a stockholders’ deficit of approximately $60.9 million, and an accumulated deficit of approximately $459.2 million. Our net income and operating loss for the three months ended September 30, 2010 were approximately $9.6 million and $3.9 million, respectively and our net loss and operating loss for the nine months ended September 30, 2010 were approximately $22.5 million and $10.0 million, respectively. Since our inception in 1986, we have generated significant losses from operations. We anticipate that we will continue to generate significant losses from operations for the foreseeable future, and that our business will require substantial additional investment that we have not yet secured. These conditions raise substantial doubt about our ability to continue as a going concern. The audit reports prepared by our independent registered public accounting firms relating to our financial statements for the years ended December 31, 2007, 2008 and 2009, respectively included an explanatory paragraph expressing substantial doubt about our ability to continue as a going concern.

			On August 26, 2010, we completed the sale of 3,497,528 shares of common stock and 2,623,146 warrants to purchase shares of common stock to certain institutional investors for gross proceeds of $3,532,503. Also, on August 26, 2010, we completed the sale of 3,497,528 shares of common stock and 2,623,146 warrants to

			purchase shares of common stock to MHR for gross proceeds of $3,532,503. Proceeds from the offering were $6.7 million. In accordance with the terms of a registration rights agreement with the institutional investors, we filed a registration statement on September 15, 2010, which was declared effective October 12, 2010.

			In connection with the August 2010 Financing, on August 25, 2010, we entered into a Waiver Agreement with MHR, pursuant to which MHR waived certain anti-dilution adjustment rights under the MHR Convertible Notes and certain warrants issued by us to MHR that would otherwise have been triggered by the August 2010 Financing. As consideration for such waiver, on August 26, 2010, we issued to MHR a warrant to purchase 975,000 shares of our common stock and agreed to reimburse MHR for 50% of its legal fees up to a maximum reimbursement of $50,000. Such warrant is the same form as the warrants issued in connection with the August 2010 Financing.

			We anticipate that we will continue to generate significant losses from operations for the foreseeable future, and that our business will require substantial additional investment that we have not yet secured. As such, we anticipate that our existing cash resources, including the amounts provided by the August 2010 Financing will enable us to continue operations through approximately December 2010, or earlier if unforeseen events arise that negatively affect our liquidity. Further, we have significant future commitments and obligations. These conditions raise substantial doubt about our ability to continue as a going concern. Consequently, the audit opinion issued by our independent registered public accounting firm relating to our financial statements for the year ended December 31, 2009 contained a going concern explanatory paragraph. We are pursuing new as well as enhanced collaborations and exploring other financing options, with the objective of minimizing dilution and disruption.

			While our plan is to raise capital when needed and/or to pursue product partnering opportunities, we cannot be sure how much we will need to spend in order to develop, market, and manufacture new products and technologies in the future. We expect to continue to spend substantial amounts on research and development, including amounts spent on conducting clinical trials for our product candidates. Further, we will not have sufficient resources to develop fully any new products or technologies unless we are able to raise substantial additional financing or to secure funds from new or existing partners. We cannot assure you that financing will be available when needed, or on favorable terms or at all. The current economic environment combined with a number of other factors pose additional challenges to the Company in securing adequate financing under acceptable terms. If additional capital is raised through the sale of equity or convertible debt securities, the issuance of such securities would result in dilution to our existing stockholders. Additionally, these conditions may increase the costs to raise capital. Our failure to raise capital when needed would adversely affect our business, financial condition, and results of operations, and could force us to reduce or discontinue operations.

	•		We may not be able to meet the covenants detailed in the Convertible Notes with MHR Institutional Partners IIA LP, which could result in an increase in the interest rate on the Convertible Notes and/or accelerated maturity of the Convertible Notes, which we would not be able to satisfy.

	•		Our stock is traded on the Over-the-Counter Bulletin Board.

Risks Related to our Business

	•		Our business will suffer if we fail or are delayed in developing and commercializing an improved oral form of Vitamin B12.

	•		We are highly dependent on the clinical success of our product candidates.

	•		We are highly dependent upon collaborative partners to develop and commercialize compounds using our delivery agents.

	•		Our collaborative partners control the clinical development of certain of our drug candidates and may terminate their efforts at will.

	•		Our product candidates are in various stages of development, and we cannot be certain that any will be suitable for commercial purposes.

	•		Our collaborative partners are free to develop competing products.

	•		Our business will suffer if we cannot adequately protect our patent and proprietary rights.

	•		We may be at risk of having to obtain a license from third parties making proprietary improvements to our technology.

	•		We are dependent on third parties to manufacture and, in some cases, test our products.

	•		We are dependent on our key personnel and if we cannot recruit and retain leaders in our research, development, manufacturing, and commercial organizations, our business will be harmed.

Risks Related to our Industry

	•		Our future business success depends heavily upon regulatory approvals, which can be difficult to obtain for a variety of reasons, including cost.

	•		We may face product liability claims related to participation in clinical trials for future products.

	•		We are subject to environmental, health and safety laws and regulations for which we incur costs to comply.

	•		We face rapid technological change and intense competition.

Other Risks

	•		Provisions of our corporate charter documents, Delaware law, our financing documents and our stockholder rights plan may dissuade potential acquirers, prevent the replacement or removal of our current management and members of our Board of Directors and may thereby affect the price of our common stock.

	•		Our stock price has been and may continue to be volatile.

	•		Future sales of common stock or warrants, or the prospect of future sales, may depress our stock price.

For a more complete listing and description of these and other risks that the Company faces, please see our Annual Report for 2009 on Form 10-K as filed with the SEC on March 25, 2010.

ITEM 2. UNREGISTERED SALES OF EQUITY SECURITIES AND USE OF PROCEEDS

On August 25, 2010, the Company entered into certain agreements, which provided for the issuance of a total of 6,995,056 shares of common stock and warrants to purchase a total of 6,221,292 additional shares of common stock. Such agreements and transactions are further described in the Company’s Current Report on Form 8-K, which was filed with the SEC on August 25, 2010.

ITEM 6. EXHIBITS


Exhibit
Number		Description of Exhibit

3.1		Amended and Restated Certificate of Incorporation of Emisphere Technologies, Inc., as amended by the Certificate of Amendment of Amended and Restated Certificate of Incorporation of Emisphere Technologies, Inc., dated April 20, 2007 (filed as Exhibit 3.1 to the Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2007 and incorporated herein by reference).

3.2		By-Laws of Emisphere Technologies, Inc., as amended December 7, 1998 (filed as Exhibit 3(ii) to the Quarterly Report on Form 10-Q for the quarterly period ended January 31, 1999) and as further amended on September 23, 2005 (filed as Exhibit 3.1 to the Current Report on Form 8-K filed on September 30, 2005 and incorporated herein by reference).

3.3		Amendment, effective as of September 11, 2007, to the Amended By-Laws of Emisphere Technologies, Inc. (filed as Exhibit 3.1 to the Current Report on Form 8-K filed on September 14, 2007 and incorporated herein by reference).

4.1		Restated Rights Agreement dated as of April 7, 2006 between Emisphere Technologies, Inc. and Mellon Investor Services, LLC (filed as Exhibit 1.1 to the Current Report on Form 8-K filed on April 10, 2006 and incorporated herein by reference.

4.2		Form of Warrant (filed as Exhibit 4.1 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

4.3		Form MHR Warrant (filed as Exhibit 4.3 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference)

10.1		Securities Purchase Agreement by and among Emisphere Technologies, Inc. and the Buyers named therein, dated August 25, 2010 (filed as Exhibit 10.1 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.2		Securities Purchase Agreement by and among Emisphere Technologies, Inc. and the MHR Buyers named therein, dated August 25, 2010 (filed as Exhibit 10.2 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.3		Waiver Agreement, by and among Emisphere Technologies, Inc. and MHR, dated August 25, 2010 (filed as Exhibit 10.3 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.4		Registration Rights Agreement by and among Emisphere Technologies, Inc. and the Buyers named therein, dated August 26, 2010 (filed as Exhibit 10.78 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference)

10.5		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Bai Ye Feng (filed as Exhibit 10.79 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.6		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Anson Investments Master Fund LP (filed as Exhibit 10.80 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.7		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Iroquois Master Fund, Ltd. (filed as Exhibit 10.81 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.8		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Hudson Bay Master Fund Ltd. (filed as Exhibit 10.82 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.9		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Cranshire Capital, L.P. (filed as Exhibit 10.83 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).


Exhibit
Number		Description of Exhibit

10.10		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Freestone Advantage Partners, LP (filed as Exhibit 10.84 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.11		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners Master Account LP (filed as Exhibit 10.85 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.12		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners (100) LP (filed as Exhibit 10.86 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.13		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners II LP (filed as Exhibit 10.87 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.14		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners IIA LP (filed as Exhibit 10.88 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.15		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners Master Account LP (filed as Exhibit 10.89 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.16		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners (100) LP (filed as Exhibit 10.90 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.17		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners II LP (filed as Exhibit 10.91 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.18		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners IIA LP (filed as Exhibit 10.92 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

31.1		Certification of the Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to section 302 of the Sarbanes- Oxley Act of 2002 (filed herewith).

31.2		Certification of the Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).

32.1		Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to section 906 of the Sarbanes-Oxley Act of 2002 (furnished herewith).

SIGNATURES

Pursuant to the requirement of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.


	Emisphere Technologies, Inc.
Date: November 12, 2010	/s/ Michael V. Novinski
	Michael V. Novinski
	President and Chief Executive Officer (Principal Executive Officer)


Date: November 12, 2010	/s/ Michael R. Garone
	Michael R. Garone
	Chief Financial Officer (Principal Financial and Accounting Officer)

EXHIBIT INDEX


Exhibit
Number		Description of Exhibit

3.1		Amended and Restated Certificate of Incorporation of Emisphere Technologies, Inc., as amended by the Certificate of Amendment of Amended and Restated Certificate of Incorporation of Emisphere Technologies, Inc., dated April 20, 2007 (filed as Exhibit 3.1 to the Quarterly Report on Form 10-Q for the fiscal quarter ended March 31, 2007 and incorporated herein by reference).

3.2		By-Laws of Emisphere Technologies, Inc., as amended December 7, 1998 (filed as Exhibit 3(ii) to the Quarterly Report on Form 10-Q for the quarterly period ended January 31, 1999) and as further amended on September 23, 2005 (filed as Exhibit 3.1 to the Current Report on Form 8-K filed on September 30, 2005 and incorporated herein by reference).

3.3		Amendment, effective as of September 11, 2007, to the Amended By-Laws of Emisphere Technologies, Inc. (filed as Exhibit 3.1 to the Current Report on Form 8-K, filed on September 14, 2007 and incorporated herein by reference).

4.1		Restated Rights Agreement dated as of April 7, 2006 between Emisphere Technologies, Inc. and Mellon Investor Services, LLC (filed as Exhibit 1.1 to the Current Report on Form 8-K filed April 10, 2006 and incorporated herein by reference.

4.2		Form of Warrant (filed as Exhibit 4.1 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

4.3		Form of Emisphere Technologies, Inc. Warrant with MHR (filed as Exhibit 4.3 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference)

10.1		Securities Purchase Agreement by and among Emisphere Technologies, Inc. and the Buyers named therein, dated August 25, 2010 (filed as Exhibit 10.1 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.2		Securities Purchase Agreement by and among Emisphere Technologies, Inc. and the MHR Buyers named therein, dated August 25, 2010 (filed as Exhibit 10.2 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.3		Waiver Agreement, by and among Emisphere Technologies, Inc. and MHR, dated August 25, 2010 (filed as Exhibit 10.3 to the Current Report on Form 8-K, filed on August 25, 2010 and incorporated herein by reference).

10.4		Registration Rights Agreement by and among Emisphere Technologies, Inc. and the Buyers named therein, dated August 26, 2010 (filed as Exhibit 10.78 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference)

10.5		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Bai Ye Feng (filed as Exhibit 10.79 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.6		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Anson Investments Master Fund LP (filed as Exhibit 10.80 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.7		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Iroquois Master Fund, Ltd. (filed as Exhibit 10.81 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.8		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Hudson Bay Master Fund Ltd. (filed as Exhibit 10.82 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.9		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Cranshire Capital, L.P. (filed as Exhibit 10.83 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).


Exhibit
Number		Description of Exhibit

10.10		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and Freestone Advantage Partners, LP (filed as Exhibit 10.84 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.11		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners Master Account LP (filed as Exhibit 10.85 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.12		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners (100) LP (filed as Exhibit 10.86 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.13		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners II LP (filed as Exhibit 10.87 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.14		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners IIA LP (filed as Exhibit 10.88 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.15		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners Master Account LP (filed as Exhibit 10.89 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.16		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Capital Partners (100) LP (filed as Exhibit 10.90 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.17		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners II LP (filed as Exhibit 10.91 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

10.18		Warrant dated as of August 26, 2010, between Emisphere Technologies, Inc. and MHR Institutional Partners IIA LP (filed as Exhibit 10.92 to the Registration Statement on Form S-1, filed on September 15, 2010 and incorporated herein by reference).

31.1		Certification of the Chief Executive Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to section 302 of the Sarbanes- Oxley Act of 2002 (filed herewith).

31.2		Certification of the Chief Financial Officer pursuant to Rule 13a-14(a) and 15d-14(a), as adopted pursuant to section 302 of the Sarbanes-Oxley Act of 2002 (filed herewith).

32.1		Certification pursuant to 18 U.S.C. Section 1350, as adopted pursuant to section 906 of the Sarbanes- Oxley Act of 2002 (furnished herewith).

EXHIBIT 31.1

CERTIFICATION PURSUANT TO
RULE 13a-14(a) AND 15d-14(a),
AS ADOPTED PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Michael V. Novinski, certify that:

	1.	I have reviewed this Quarterly Report on Form 10-Q of Emisphere Technologies, Inc;

	2.	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

	3.	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

	4.	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

	a.		Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

	b.		Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

	c.		Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

	d.		Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

	a.		All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

	b.		Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 12, 2010


	/s/ Michael V. Novinski
	Michael V. Novinski
	President and Chief Executive Officer

EXHIBIT 31.2

CERTIFICATION PURSUANT TO
RULE 13a-14(a) AND 15d-14(a),
AS ADOPTED PURSUANT TO
SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Michael R. Garone, certify that:

	1.	I have reviewed this Quarterly Report on Form 10-Q of Emisphere Technologies, Inc;

	2.	Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

	3.	Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the registrant as of, and for, the periods presented in this report;

	4.	The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d- 15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

	a.		Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

	b.		Designed such internal control over financial reporting, or caused such internal control over financial reporting to be designed under our supervision, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles;

	c.		Evaluated the effectiveness of the registrant’s disclosure controls and procedures and presented in this report our conclusions about the effectiveness of the disclosure controls and procedures, as of the end of the period covered by this report based on such evaluation; and

	d.		Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and

	5.	The registrant’s other certifying officer and I have disclosed, based on our most recent evaluation of internal control over financial reporting, to the registrant’s auditors and the audit committee of the registrant’s board of directors (or persons performing the equivalent functions):

	a.		All significant deficiencies and material weaknesses in the design or operation of internal control over financial reporting which are reasonably likely to adversely affect the registrant’s ability to record, process, summarize and report financial information; and

	b.		Any fraud, whether or not material, that involves management or other employees who have a significant role in the registrant’s internal control over financial reporting.

Date: November 12, 2010


	/s/ Michael R. Garone
	Michael R. Garone
	Chief Financial Officer

EXHIBIT 32.1

CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350,
AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Emisphere Technologies, Inc. (the “Company”) on Form 10-Q for the quarterly period ending September 30, 2010 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), we, Michael V. Novinski, as President and Chief Executive Officer, and Michael R. Garone, as Chief Financial Officer, of the Company certify, pursuant to and for the purpose of 18 U.S.C. Section 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, that:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

Date: November 12, 2010


	/s/ Michael V. Novinski
	Michael V. Novinski
	President and Chief Executive Officer


	/s/ Michael R. Garone
	Michael R. Garone
	Chief Financial Officer

A signed original of this written statement required by Section 906 has been provided to Emisphere Technologies, Inc. and will be retained by Emisphere Technologies, Inc. and furnished to the Securities and Exchange Commission or its staff upon request.

Emisphere (EMIS) Inactive 424B3Prospectus supplement