Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	444	6,100	SH		DFND	2	6,100	0	0
AbbVie Inc.	Common	00287Y109	364	5,000	SH		DFND	1	0	5,000	0
Acceleron Pharma, Inc.	Common	00434H108	731	17,800	SH		DFND	2	17,800	0	0
Aimmune Therapeutics, Inc.	Common	00900T107	1,196	57,456	SH		DFND	2	57,456	0	0
Alcon, Inc	Common	H01301128	37	600	SH		DFND	2	600	0	0
Alimera Sciences, Inc.	Common	016259103	396	444,401	SH		DFND	2	444,401	0	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	1,456	49,000	SH		DFND	1	0	49,000	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	45	1,500	SH		DFND	1	1,500	0	0
Alerian MLP	Common	00162Q866	6	600	SH		DFND	1	0	600	0
Alphabet Inc-Cl C	Common	02079K107	8,539	7,900	SH		DFND	2	7,900	0	0
American Outdoor Brands Corporation	Common	02874P103	3,514	390,000	SH		DFND	2	390,000	0	0
Anadarko Petroleum Corporation	Common	032511107	501	7,100	SH		DFND	1	0	7,100	0
Anadarko Petroleum Corporation	Common	032511107	625	8,860	SH		DFND	1	8,860	0	0
Apollo Global Management, LLC	Common	037612306	11,069	322,708	SH		DFND	2	322,708	0	0
Apple Inc.	Common	037833100	4,750	24,000	SH		DFND	2	24,000	0	0
Apple Inc.	Common	037833100	104	525	SH		DFND	1	0	525	0
Apple Inc.	Common	037833100	104	525	SH		DFND	1	525	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	1,075	18,332	SH		DFND	2	18,332	0	0
Ascendis Pharma A/S	Common	BV9G6B8US	76	656	SH		DFND	2	656	0	0
AT&T Inc.	Common	00206R102	670	20,000	SH		DFND	1	0	20,000	0
AT&T Inc.	Common	00206R102	69	2,050	SH		DFND	1	2,050	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	382	58,000	SH		DFND	2	58,000	0	0
Bank Nova Scotia Halifax	Common	064149107	22	400	SH		DFND	1	0	400	0
Bellicum Pharmaceuticals, Inc.	Common	079481107	435	255,703	SH		DFND	2	255,703	0	0
Bellicum Pharm., Inc. 5	Common	9EDW5GYA8	50	100	SH		DFND	2	100	0	0
BioDelivery Sciences International, Inc.	Common	09060J106	2,106	452,802	SH		DFND	2	452,802	0	0
Bristol-Myers Squibb Company	Common	110122108	1,228	27,080	SH		DFND	2	27,080	0	0
Calumet Specialty Products Partners, LP	Common	131476103	7,992	1,907,436	SH		DFND	2	1,907,436	0	0
Calumet Specialty Products Partners, LP	Common	131476103	84	20,000	SH		DFND	1	20,000	0	0
Canadian Natural Resources Inc.	Common	136385101	371	13,750	SH		DFND	1	0	13,750	0
Canadian Natural Resources Inc.	Common	136385101	502	18,600	SH		DFND	1	18,600	0	0
Capitol Federal Financial Inc.	Common	14057J101	55	4,000	SH		DFND	1	0	4,000	0
Capitol Federal Financial Inc.	Common	14057J101	80	5,800	SH		DFND	1	5,800	0	0
Catalyst Pharmaceuticals, Inc.	Common	14888U101	1,318	343,347	SH		DFND	2	343,347	0	0
Celgene Corporation	Common	151020104	1,465	15,847	SH		DFND	2	15,847	0	0
Centerstate Banks Corp	Common	15201P109	41	1,780	SH		DFND	1	0	1,780	0
Centerstate Banks Corp	Common	15201P109	119	5,162	SH		DFND	1	5,162	0	0
Check Cap Ltd.	Common	M2361E203	5	2,224	SH		DFND	2	2,224	0	0
Check Cap Ltd. 7.50	Common	M2361E120	482	64,309	SH		DFND	2	64,309	0	0
Chemours Co.	Common	163851108	15	640	SH		DFND	1	0	640	0
Chemours Co.	Common	163851108	17	720	SH		DFND	1	720	0	0
Cidara Therapeutics, Inc.	Common	171757107	216	128,527	SH		DFND	2	128,527	0	0
Coherus Biosciences, Inc.	Common	19249H103	1,379	62,387	SH		DFND	2	62,387	0	0
Coca Cola	Common	191216100	387	7,600	SH		DFND	1	0	7,600	0
Coca Cola	Common	191216100	295	5,800	SH		DFND	1	5,800	0	0
Colony Northstar Inc.	Common	19625W104	7	1,466	SH		DFND	1	0	1,466	0
Columbia Financial, Inc.	Common	197641103	353	23,363	SH		DFND	2	23,363	0	0
Community Healthcare Trust Incorporated	Common	20369C106	2,365	60,000	SH		DFND	2	60,000	0	0
Conagra Brands	Common	205887102	265	10,000	SH		DFND	1	0	10,000	0
Corteva Inc.	Common	22052L104	327	11,051	SH		DFND	1	0	11,051	0
Corteva Inc.	Common	22052L104	44	1,494	SH		DFND	1	1,494	0	0
Cousins Properties	Common	222795106	121	3,357	SH		DFND	1	0	3,357	0
CymaBay Therapeutics, Inc.	Common	23257D103	150	21,000	SH		DFND	2	21,000	0	0
Dell Technologies Inc.	Common	24703L202	326	6,426	SH		DFND	2	6,426	0	0
Delta Air Lines, Inc.	Common	247361702	3,263	57,500	SH		DFND	2	57,500	0	0
Dow Inc.	Common	260557103	545	11,051	SH		DFND	1	0	11,051	0
Dow Inc.	Common	260557103	74	1,494	SH		DFND	1	1,494	0	0
Dupont DE Nemours Inc.	Common	26614N102	830	11,051	SH		DFND	1	0	11,051	0
Dupont DE Nemours Inc.	Common	26614N102	112	1,494	SH		DFND	1	1,494	0	0
Eagle Materials Inc.	Common	26969P108	21	228	SH		DFND	1	0	228	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,300	216,969	SH		DFND	2	216,969	0	0
Eli Lilly Inc.	Common	532457108	33	300	SH		DFND	1	0	300	0
Entegra Financial Corporation	Common	29363J108	90	3,000	SH		DFND	1	0	3,000	0
Entegra Financial Corporation	Common	29363J108	218	7,250	SH		DFND	1	7,250	0	0
Essential Properties Realty Trust, Inc.	Common	29670E107	802	40,000	SH		DFND	2	40,000	0	0
FNB Coporation	Common	302520101	105	8,905	SH		DFND	1	0	8,905	0
Fannie Mae 8.25 Series T	Common	313586737	996	85,000	SH		DFND	2	85,000	0	0
Foamix Pharmaceuticals Ltd.	Common	M46135105	883	371,046	SH		DFND	2	371,046	0	0
Ford Motor Company	Common	345370860	51	5,000	SH		DFND	1	0	5,000	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	13,190	873,509	SH		DFND	2	873,509	0	0
FS Bancorp Inc.	Common	30263Y104	76	1,460	SH		DFND	1	0	1,460	0
FS Bancorp Inc.	Common	30263Y104	110	2,117	SH		DFND	1	2,117	0	0
Freddie Mac 8.375 Series Z	Common	313400624	662	53,350	SH		DFND	2	53,350	0	0
General Electric	Common	369604103	13	1,200	SH		DFND	1	0	1,200	0
General Electric	Common	369604103	37	3,480	SH		DFND	1	3,480	0	0
General Motors	Common	37045V100	193	5,000	SH		DFND	1	0	5,000	0
Gilead Sciences, Inc.	Common	375558103	236	3,500	SH		DFND	2	3,500	0	0
Global Medical REIT, Inc. Ser A Cum Pfd.	Common	37957W203	918	35,000	SH		DFND	2	35,000	0	0
Globus Medical, Inc.	Common	379577208	80	1,900	SH		DFND	2	1,900	0	0
Heritage NOLA Bancorp Inc.	Common	42727P108	38	3,000	SH		DFND	1	0	3,000	0
Heritage NOLA Bancorp Inc.	Common	42727P108	115	9,000	SH		DFND	1	9,000	0	0
Hospitality Properties Trust	Common	44106M102	625	25,000	SH		DFND	1	0	25,000	0
Horizon Therapeutics Public Ltd. Company	Common	G4617B105	1,204	50,046	SH		DFND	2	50,046	0	0
Intec Pharma Ltd.	Common	M53644106	1,126	259,377	SH		DFND	2	259,377	0	0
International Business Machines	Common	459200101	591	4,284	SH		DFND	1	0	4,284	0
International Gaming Technologies	Common	G4863A108	7,782	600,000	SH		DFND	2	600,000	0	0
International Gaming Technologies	Common	G4863A108	97	7,500	SH		DFND	1	0	7,500	0
Johnson & Johnson	Common	478160104	306	2,200	SH		DFND	1	0	2,200	0
Johnson & Johnson	Common	478160104	708	5,080	SH		DFND	1	5,080	0	0
JP Morgan & Chase	Common	46625H100	984	8,800	SH		DFND	1	0	8,800	0
JP Morgan & Chase	Common	46625H100	1,593	14,250	SH		DFND	1	14,250	0	0
Kimberly Clark Corporation	Common	494368103	800	6,000	SH		DFND	1	0	6,000	0
Krystal Biotech, Inc.	Common	501147102	233	5,797	SH		DFND	2	5,797	0	0
Legacy Housing Corporation	Common	52472M101	50	4,000	SH		DFND	1	0	4,000	0
Legacy Housing Corporation	Common	52472M101	62	5,000	SH		DFND	1	5,000	0	0
Lexicon Pharmaceuticals, Inc.	Common	528872302	189	30,000	SH		DFND	2	30,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	39,062	342,198	SH		DFND	2	342,198	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	210	1,843	SH		DFND	1	0	1,843	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	1,027	9,000	SH		DFND	1	9,000	0	0
LKQ Corporation	Common	501889208	7,983	300,000	SH		DFND	2	300,000	0	0
Lowe's Companies, Inc.	Common	548661107	4,541	45,000	SH		DFND	2	45,000	0	0
Macquarie Infrastructure Corporation	Common	55608B105	6,632	163,600	SH		DFND	2	163,600	0	0
Macquarie Infrastructure Corporation	Common	55608B105	365	9,000	SH		DFND	1	0	9,000	0
Macquarie Infrastructure Corporation	Common	55608B105	134	3,300	SH		DFND	1	3,300	0	0
Medtronics Inc.	Common	G5960L103	102	1,050	SH		DFND	1	0	1,050	0
MEI Pharma, Inc.	Common	55279B202	96	38,590	SH		DFND	2	38,590	0	0
Merck & Co. Inc.	Common	58993Y105	42	500	SH		DFND	1	0	500	0
Merck & Co. Inc.	Common	58993Y105	67	800	SH		DFND	1	800	0	0
Microsoft Corporation	Common	594918104	134	1,000	SH		DFND	1	0	1,000	0
Microsoft Corporation	Common	594918104	54	400	SH		DFND	1	400	0	0
Mondelez Int'l Inc.	Common	609207105	701	13,000	SH		DFND	1	0	13,000	0
Mondelez Int'l Inc.	Common	609207105	156	2,900	SH		DFND	1	2,900	0	0
MPLX LP	Common	55336V100	10,608	329,558	SH		DFND	2	329,558	0	0
Novartis AG	Common	66987V109	274	3,000	SH		DFND	2	3,000	0	0
Novelion Therapeutics, Inc.	Common	67001K202	85	109,135	SH		DFND	2	109,135	0	0
Och-Ziff Capital Management Group	Common	67551U105	5	200	SH		DFND	1	200	0	0
Oritani Financial Corp	Common	68633D103	34	2,000	SH		DFND	1	0	2,000	0
Oritani Financial Corp	Common	68633D103	103	5,800	SH		DFND	1	5,800	0	0
Orthofix Medical Inc.	Common	68752M108	106	2,000	SH		DFND	2	2,000	0	0
Peoples United Financial	Common	712704105	25	1,500	SH		DFND	1	0	1,500	0
Pfizer Inc.	Common	717081103	4,375	101,000	SH		DFND	1	0	101,000	0
Pfizer Inc.	Common	717081103	1,906	44,000	SH		DFND	1	44,000	0	0
Quotient Limited	Common	G73268107	1,590	170,000	SH		DFND	2	170,000	0	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND	1	0	16	0
Radius Health Inc.	Common	750469207	1,882	77,269	SH		DFND	2	77,269	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	973	12,000	SH		DFND	1	0	12,000	0
Ryman Hospitality Ppty Inc.	Common	78377T107	32	400	SH		DFND	1	400	0	0
Starwood Ppty	Common	85571B105	9	400	SH		DFND	1	400	0	0
Stemline Therapeutics, Inc.	Common	85858C107	1,542	100,634	SH		DFND	2	100,634	0	0
Stericycle, Inc.	Common	858912108	12,849	269,083	SH		DFND	2	269,083	0	0
The Howard Hughes Corporation	Common	44267D107	1,610	13,000	SH		DFND	2	13,000	0	0
The Michaels Companies, Inc.	Common	59408Q106	2,610	300,000	SH		DFND	2	300,000	0	0
The Kraft Heinz Company	Common	500754106	182	5,865	SH		DFND	1	0	5,865	0
The Kraft Heinz Company	Common	500754106	94	3,035	SH		DFND	1	3,035	0	0
The Stars Group Inc.	Common	85570W100	8,037	470,800	SH		DFND	2	470,800	0	0
Totol SA	Common	89151E109	162	2,900	SH		DFND	1	0	2,900	0
Totol SA	Common	89151E109	132	2,360	SH		DFND	1	2,360	0	0
Upland Software, Inc.	Common	91544A109	19,942	438,000	SH		DFND	2	438,000	0	0
Verizon Communications Inc.	Common	92343V104	971	16,991	SH		DFND	1	0	16,991	0
Verizon Communications Inc.	Common	92343V104	75	1,320	SH		DFND	1	1,320	0	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	129	11,107	SH		DFND	2	11,107	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,810	218,102	SH		DFND	2	218,102	0	0
Viveve Medical, Inc.	Common	92852W204	17	43,649	SH		DFND	2	43,649	0	0
WABTEC	Common	929740108	0	6	SH		DFND	1	0	6	0
WABTEC	Common	929740108	1	17	SH		DFND	1	17	0	0
Wheeler Real Estate Investment Trust, Inc.	Common	963025606	215	14,309	SH		DFND	2	14,309	0	0
WP Carey	Common	92936U109	487	6,000	SH		DFND	1	0	6,000	0
Xenon Pharmaceuticals Inc.	Common	98420N105	1,769	179,390	SH		DFND	2	179,390	0	0