Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	2,475	27,953	SH		DFND	2	0	27,953	0
AbbVie Inc.	Common	00287Y109	443	5,000	SH		DFND	1	0	5,000	0
Acceleron Pharma, Inc.	Common	00434H108	294	5,547	SH		DFND	2	0	5,547	0
Aimmune Therapeutics, Inc.	Common	00900T107	1,874	55,990	SH		DFND	2	0	55,990	0
Alimera Sciences, Inc.	Common	016259202	342	45,155	SH		DFND	2	0	45,155	0
Alkermes PLC	Common	G01767105	879	43,073	SH		DFND	2	0	43,073	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	1,483	49,000	SH		DFND	1	0	49,000	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	45	1,500	SH		DFND	1	0	1,500	0
Alerian MLP	Common	00162Q866	5	600	SH		DFND	1	0	600	0
Alphabet Inc-Cl C	Common	02079K107	10,562	7,900	SH		DFND	2	0	7,900	0
American Outdoor Brands Corporation	Common	02874P103	3,619	390,000	SH		DFND	2	0	390,000	0
Apollo Global Management, Inc.	Common	03768E105	11,331	237,500	SH		DFND	2	0	237,500	0
Apple Inc.	Common	037833100	154	525	SH		DFND	1	0	525	0
Apple Inc.	Common	037833100	154	525	SH		DFND	1	0	525	0
Arena Pharmaceuticals, Inc.	Common	040047607	654	14,391	SH		DFND	2	0	14,391	0
Ascendis Pharma A/S	Common	04351P101	91	656	SH		DFND	2	0	656	0
AT&T Inc.	Common	00206R102	782	20,000	SH		DFND	1	0	20,000	0
AT&T Inc.	Common	00206R102	80	2,050	SH		DFND	1	0	2,050	0
Bank Nova Scotia Halifax	Common	064149107	23	400	SH		DFND	1	0	400	0
BELLUS Health Inc.	Common	07987C204	1,833	242,611	SH		DFND	2	0	242,611	0
BioDelivery Sciences International, Inc.	Common	09060J106	3,189	504,607	SH		DFND	2	0	504,607	0
Bristol-Myers Squibb Company	Common	110122108	2,806	43,715	SH		DFND	2	0	43,715	0
Bristol-Myers Squibb Company - CVR	Common	110122157	48	15,847	SH		DFND	2	0	15,847	0
Calumet Specialty Products Partners, LP	Common	131476103	7,300	2,000,000	SH		DFND	2	0	2,000,000	0
Calumet Specialty Products Partners, LP	Common	131476103	73	20,000	SH		DFND	1	0	20,000	0
Canadian Natural Resources Inc.	Common	136385101	445	13,750	SH		DFND	1	0	13,750	0
Canadian Natural Resources Inc.	Common	136385101	592	18,285	SH		DFND	1	0	18,285	0
Capitol Federal Financial Inc.	Common	14057J101	55	4,000	SH		DFND	1	0	4,000	0
Capitol Federal Financial Inc.	Common	14057J101	80	5,800	SH		DFND	1	0	5,800	0
Catalyst Pharmaceuticals, Inc.	Common	14888U101	219	58,317	SH		DFND	2	0	58,317	0
Centerstate Banks Corp	Common	15201P109	44	1,780	SH		DFND	1	0	1,780	0
Centerstate Banks Corp	Common	15201P109	129	5,162	SH		DFND	1	0	5,162	0
Check Cap Ltd.	Common	M2361E203	4	2,224	SH		DFND	2	0	2,224	0
Check Cap Ltd. @7.50 Exp. 2/28/20	Common	M2361E120	482	64,309	SH		DFND	2	0	64,309	0
Chemours Co.	Common	163851108	8	440	SH		DFND	1	0	440	0
Chemours Co.	Common	163851108	13	720	SH		DFND	1	0	720	0
ChemoCentryx, Inc.	Common	16383L106	4,195	106,075	SH		DFND	2	0	106,075	0
Cidara Therapeutics, Inc.	Common	171757107	838	218,220	SH		DFND	2	0	218,220	0
Coca Cola	Common	191216100	421	7,600	SH		DFND	1	0	7,600	0
Coca Cola	Common	191216100	321	5,800	SH		DFND	1	0	5,800	0
Coherus Biosciences, Inc.	Common	19249H103	1,363	75,714	SH		DFND	2	0	75,714	0
Collegium Pharmaceutical, Inc.	Common	19459J104	257	12,500	SH		DFND	2	0	12,500	0
Colony Northstar Inc.	Common	19625W104	7	1,466	SH		DFND	1	0	1,466	0
Columbia Financial, Inc.	Common	197641103	396	23,363	SH		DFND	2	0	23,363	0
Conagra Brands	Common	205887102	342	10,000	SH		DFND	1	0	10,000	0
Corteva Inc.	Common	22052L104	327	11,051	SH		DFND	1	0	11,051	0
Corteva Inc.	Common	22052L104	44	1,494	SH		DFND	1	0	1,494	0
Cousins Properties	Common	222795106	138	3,357	SH		DFND	1	0	3,357	0
Dell Technologies Inc.	Common	24703L202	330	6,426	SH		DFND	2	0	6,426	0
Dow Inc.	Common	260557103	605	11,051	SH		DFND	1	0	11,051	0
Dow Inc.	Common	260557103	82	1,494	SH		DFND	1	0	1,494	0
Dupont De Nemours Inc.	Common	26614N102	709	11,051	SH		DFND	1	0	11,051	0
Dupont De Nemours Inc.	Common	26614N102	96	1,494	SH		DFND	1	0	1,494	0
Eagle Materials Inc.	Common	26969P108	21	228	SH		DFND	1	0	228	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	3,493	234,448	SH		DFND	2	0	234,448	0
Eli Lilly Inc.	Common	532457108	39	300	SH		DFND	1	0	300	0
Entegra Financial Corporation	Common	29363J108	90	3,000	SH		DFND	1	0	3,000	0
Entegra Financial Corporation	Common	29363J108	219	7,250	SH		DFND	1	0	7,250	0
Fannie Mae 4.75 percent Series M	Common	313586836	851	43,000	SH		DFND	2	0	43,000	0
Fannie Mae 5.1 percent Series E	Common	313586604	319	17,500	SH		DFND	2	0	17,500	0
Fannie Mae 5.125 percent Series L	Common	313586844	173	8,680	SH		DFND	2	0	8,680	0
Fannie Mae 5.81 percent Series H	Common	313586885	198	10,000	SH		DFND	2	0	10,000	0
Fannie Mae 8.25 percent Series S	Common	313586752	418	35,000	SH		DFND	2	0	35,000	0
Fannie Mae 8.25 percent Series T	Common	313586737	1,663	146,736	SH		DFND	2	0	146,736	0
Fannie Mae Float - Series G	Common	313586802	393	22,477	SH		DFND	2	0	22,477	0
Fannie Mae Float Series F	Common	313586703	1,507	81,890	SH		DFND	2	0	81,890	0
Fannie Mae Float Series P	Common	313586786	2,670	254,559	SH		DFND	2	0	254,559	0
Foamix Pharmaceuticals Ltd.	Common	M46135105	1,269	381,146	SH		DFND	2	0	381,146	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	17,361	888,509	SH		DFND	2	0	888,509	0
Freddie Mac 5 percent Series F	Common	313400863	394	21,590	SH		DFND	2	0	21,590	0
Freddie Mac 5.3 percent	Common	313400822	534	30,000	SH		DFND	2	0	30,000	0
Freddie Mac 5.57 percent Series V	Common	313400673	794	80,000	SH		DFND	2	0	80,000	0
Freddie Mac 5.9 percent Series U	Common	313400681	100	10,000	SH		DFND	2	0	10,000	0
Freddie Mac 6 percent Series P	Common	313400749	104	5,200	SH		DFND	2	0	5,200	0
Freddie Mac 6.02 percent Series X	Common	313400657	610	53,811	SH		DFND	2	0	53,811	0
Freddie Mac 8.375 percent Series Z	Common	313400624	1,653	139,500	SH		DFND	2	0	139,500	0
FNB Corporation	Common	302520101	113	8,905	SH		DFND	1	0	8,905	0
FS Bancorp Inc.	Common	30263Y104	93	1,460	SH		DFND	1	0	1,460	0
FS Bancorp Inc.	Common	30263Y104	135	2,117	SH		DFND	1	0	2,117	0
FS KKR Capital Corp.	Common	302635107	8,582	1,400,000	SH		DFND	2	0	1,400,000	0
FS KKR Capital Corp.	Common	302635107	644	105,000	SH		DFND	1	0	105,000	0
FS KKR Capital Corp.	Common	302635107	135	22,000	SH		DFND	1	0	22,000	0
General Electric	Common	369604103	13	1,200	SH		DFND	1	0	1,200	0
General Electric	Common	369604103	39	3,480	SH		DFND	1	0	3,480	0
Global Medical REIT, Inc. Ser A Cum Pfd.	Common	37957W203	943	35,000	SH		DFND	2	0	35,000	0
Globus Medical, Inc.	Common	379577208	171	2,900	SH		DFND	2	0	2,900	0
Heritage NOLA Bancorp Inc.	Common	42727P108	38	3,000	SH		DFND	1	0	3,000	0
Heritage NOLA Bancorp Inc.	Common	42727P108	115	9,000	SH		DFND	1	0	9,000	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	2,203	60,856	SH		DFND	2	0	60,856	0
International Business Machines	Common	459200101	574	4,284	SH		DFND	1	0	4,284	0
International Gaming Technologies	Common	G4863A108	112	7,500	SH		DFND	1	0	7,500	0
International Gaming Technologies	Common	G4863A108	8,982	600,000	SH		DFND	2	0	600,000	0
Johnson & Johnson	Common	478160104	321	2,200	SH		DFND	1	0	2,200	0
Johnson & Johnson	Common	478160104	741	5,080	SH		DFND	1	0	5,080	0
JP Morgan Chase	Common	46625H100	1,237	8,800	SH		DFND	1	0	8,800	0
JP Morgan Chase	Common	46625H100	1,986	14,250	SH		DFND	1	0	14,250	0
Kadmon Holdings, Inc.	Common	48283N106	1,246	275,000	SH		DFND	2	0	275,000	0
Kimberly Clark Corporation	Common	494368103	825	6,000	SH		DFND	1	0	6,000	0
Krystal Biotech, Inc.	Common	501147102	392	7,079	SH		DFND	2	0	7,079	0
Legacy Housing Corporation	Common	52472M101	67	4,000	SH		DFND	1	0	4,000	0
Legacy Housing Corporation	Common	52472M101	83	5,000	SH		DFND	1	0	5,000	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	35,688	342,198	SH		DFND	2	0	342,198	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	192	1,843	SH		DFND	1	0	1,843	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	939	9,000	SH		DFND	1	0	9,000	0
LKQ Corporation	Common	501889208	7,140	200,000	SH		DFND	2	0	200,000	0
Macquarie Infrastructure Corporation	Common	55608B105	7,009	163,600	SH		DFND	2	0	163,600	0
Macquarie Infrastructure Corporation	Common	55608B105	386	9,000	SH		DFND	1	0	9,000	0
Macquarie Infrastructure Corporation	Common	55608B105	141	3,300	SH		DFND	1	0	3,300	0
MEI Pharma, Inc.	Common	55279B202	96	38,590	SH		DFND	2	0	38,590	0
MPLX LP	Common	55336V100	9,333	366,558	SH		DFND	2	0	366,558	0
Medtronics	Common	G5960L103	119	1,050	SH		DFND	1	0	1,050	0
Merck & Co. Inc.	Common	58993Y105	45	500	SH		DFND	1	0	500	0
Merck & Co. Inc.	Common	58993Y105	73	800	SH		DFND	1	0	800	0
Microsoft Corporation	Common	594918104	158	1,000	SH		DFND	1	0	1,000	0
Microsoft Corporation	Common	594918104	63	400	SH		DFND	1	0	400	0
Mondelez Int'lt Inc.	Common	609207105	716	13,000	SH		DFND	1	0	13,000	0
Mondelez Int'lt Inc.	Common	609207105	160	2,900	SH		DFND	1	0	2,900	0
Novelion Therapeutics, Inc.	Common	67001K202	77	109,135	SH		DFND	2	0	109,135	0
Occidental Pete Corp	Common	674599105	52	1,273	SH		DFND	1	0	1,273	0
Occidental Pete Corp	Common	674599105	70	1,700	SH		DFND	1	0	1,700	0
Peoples United Financial	Common	712704105	25	1,500	SH		DFND	1	0	1,500	0
Pfizer Inc.	Common	717081103	3,957	101,000	SH		DFND	1	0	101,000	0
Pfizer Inc.	Common	717081103	1,211	30,900	SH		DFND	1	0	30,900	0
Quotient Limited	Common	G73268107	671	70,542	SH		DFND	2	0	70,542	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND	1	0	16	0
Radius Health Inc.	Common	750469207	1,323	65,617	SH		DFND	2	0	65,617	0
Ryman Hospitality Ppty Inc.	Common	78377T107	1,040	12,000	SH		DFND	1	0	12,000	0
Ryman Hospitality Ppty Inc.	Common	78377T107	35	400	SH		DFND	1	0	400	0
Sculptor Capital Mgmt	Common	811246107	4	200	SH		DFND	1	0	200	0
Service Ppty Trust	Common	81761L102	24	1,000	SH		DFND	1	0	1,000	0
Starwood Ppty	Common	85571B105	10	400	SH		DFND	1	0	400	0
Stemline Therapeutics, Inc.	Common	85858C107	1,546	145,475	SH		DFND	2	0	145,475	0
Stericycle, Inc.	Common	858912108	17,170	269,083	SH		DFND	2	0	269,083	0
Strongbridge Biopharma PLC	Common	G85347105	209	100,000	SH		DFND	2	0	100,000	0
The Stars Group Inc.	Common	85570W100	6,523	250,000	SH		DFND	2	0	250,000	0
The Kraft Heinz Company	Common	500754106	60	1,865	SH		DFND	1	0	1,865	0
The Kraft Heinz Company	Common	500754106	98	3,035	SH		DFND	1	0	3,035	0
Total SA	Common	89151E109	28	500	SH		DFND	1	0	500	0
Total SA	Common	89151E109	131	2,360	SH		DFND	1	0	2,360	0
uniQure N.V.	Common	N90064101	351	4,900	SH		DFND	2	0	4,900	0
Upland Software, Inc.	Common	91544A109	15,641	438,000	SH		DFND	2	0	438,000	0
Valley National Bancorp	Common	919794107	37	3,200	SH		DFND	1	0	3,200	0
Valley National Bancorp	Common	919794107	106	9,280	SH		DFND	1	0	9,280	0
Verizon Communications Inc.	Common	92343V104	1,043	16,991	SH		DFND	1	0	16,991	0
Verizon Communications Inc.	Common	92343V104	81	1,320	SH		DFND	1	0	1,320	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	162	10,207	SH		DFND	2	0	10,207	0
Viking Therapeutics, Inc.	Common	92686J106	1,749	218,102	SH		DFND	2	0	218,102	0
WABTEC	Common	929740108	0	6	SH		DFND	1	0	6	0
WABTEC	Common	929740108	1	17	SH		DFND	1	0	17	0
Wheeler Real Estate Investment Trust, Inc.	Common	963025606	214	14,309	SH		DFND	2	0	14,309	0
WP Carey	Common	92936U109	480	6,000	SH		DFND	1	0	6,000	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,565	195,657	SH		DFND	2	0	195,657	0