Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	3,217	32,769	SH		DFND	2	0	32,769	0
AbbVie Inc.	Common	00287Y109	491	5,000	SH		DFND	1	0	5,000	0
ADMA Biologics, Inc.	Common	000899104	586	200,157	SH		DFND	2	0	200,157	0
Alimera Sciences, Inc.	Common	016259103	505	80,194	SH		DFND	2	0	80,194	0
Alkermes PLC	Common	G01767105	1,127	58,073	SH		DFND	2	0	58,073	0
Alerian MLP	Common	00162Q452	3	120	SH		DFND	1	0	120	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	41	1,500	SH		DFND	1	0	1,500	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	1,335	49,000	SH		DFND	1	0	49,000	0
Alphabet Inc-Cl C	Common	02079K107	7,916	5,600	SH		DFND	2	0	5,600	0
Apple Inc.	Common	037833100	192	525	SH		DFND	1	0	525	0
Apple Inc.	Common	037833100	192	525	SH		DFND	1	0	525	0
Apollo Global Management, Inc.	Common	03768E105	14,976	300,000	SH		DFND	2	0	300,000	0
AT&T Inc.	Common	00206R102	62	2,050	SH		DFND	1	0	2,050	0
AT&T Inc.	Common	00206R102	605	20,000	SH		DFND	1	0	20,000	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	1,866	114,810	SH		DFND	2	0	114,810	0
Bank Nova Scotia Halifax	Common	064149107	16	400	SH		DFND	1	0	400	0
BELLUS Health Inc.	Common	07987C204	2,468	238,611	SH		DFND	2	0	238,611	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	1,893	397,361	SH		DFND	2	0	397,361	0
BioDelivery Sciences International, Inc.	Common	09060J106	2,204	505,530	SH		DFND	2	0	505,530	0
Bristol-Myers Squibb Company	Common	110122108	2,729	46,409	SH		DFND	2	0	46,409	0
Calumet Specialty Products Partners, LP	Common	131476103	4,560	2,000,000	SH		DFND	2	0	2,000,000	0
Calumet Specialty Products Partners, LP	Common	131476103	46	20,000	SH		DFND	1	0	20,000	0
Canadian Natural Resources Inc.	Common	136385101	319	18,285	SH		DFND	1	0	18,285	0
Canadian Natural Resources Inc.	Common	136385101	240	13,750	SH		DFND	1	0	13,750	0
Capitol Federal Financial Inc.	Common	14057J101	64	5,800	SH		DFND	1	0	5,800	0
Catalyst Pharmaceuticals, Inc.	Common	14888U101	195	42,117	SH		DFND	2	0	42,117	0
Check Cap Ltd.	Common	M2361E203	1	2,224	SH		DFND	2	0	2,224	0
Chemours Co.	Common	163851108	11	720	SH		DFND	1	0	720	0
Chemours Co.	Common	163851108	7	440	SH		DFND	1	0	440	0
ChemoCentryx, Inc.	Common	16383L106	4,317	75,033	SH		DFND	2	0	75,033	0
Cidara Therapeutics, Inc.	Common	171757107	1,502	407,061	SH		DFND	2	0	407,061	0
Coca Cola	Common	191216100	259	5,800	SH		DFND	1	0	5,800	0
Coca Cola	Common	191216100	340	7,600	SH		DFND	1	0	7,600	0
Coherus Biosciences, Inc.	Common	19249H103	1,868	104,566	SH		DFND	2	0	104,566	0
Collegium Pharmaceutical, Inc.	Common	19459J104	1,208	69,051	SH		DFND	2	0	69,051	0
Colony Cap Inc.	Common	19626G108	4	1,466	SH		DFND	1	0	1,466	0
Conagra Brands	Common	205887102	352	10,000	SH		DFND	1	0	10,000	0
Corteva Inc.	Common	22052L104	40	1,494	SH		DFND	1	0	1,494	0
Corteva Inc.	Common	22052L104	296	11,051	SH		DFND	1	0	11,051	0
Cousins Properties	Common	222795502	100	3,357	SH		DFND	1	0	3,357	0
Cytokinetics Incorporated	Common	23282W605	210	8,923	SH		DFND	2	0	8,923	0
Dell Technologies Inc.	Common	24703L202	353	6,426	SH		DFND	2	0	6,426	0
Dow Inc.	Common	260557103	61	1,494	SH		DFND	1	0	1,494	0
Dow Inc.	Common	260557103	433	10,624	SH		DFND	1	0	10,624	0
Dupont De Nemours Inc.	Common	26614N102	79	1,494	SH		DFND	1	0	1,494	0
Dupont De Nemours Inc.	Common	26614N102	564	10,624	SH		DFND	1	0	10,624	0
Eagle Materials	Common	26969P108	16	228	SH		DFND	1	0	228	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,532	263,748	SH		DFND	2	0	263,748	0
Eli Lilly Inc.	Common	532457108	49	300	SH		DFND	1	0	300	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	9,093	700,000	SH		DFND	2	0	700,000	0
FNB Corporation	Common	302520101	67	8,905	SH		DFND	1	0	8,905	0
FS Bancorp	Common	30263Y104	82	2,117	SH		DFND	1	0	2,117	0
FS Bancorp	Common	30263Y104	56	1,460	SH		DFND	1	0	1,460	0
FS KKR Capital Corp.	Common	302635206	4,900	350,000	SH		DFND	2	0	350,000	0
FS KKR Capital Corp.	Common	302635206	225	16,050	SH		DFND	1	0	16,050	0
FS KKR Capital Corp.	Common	302635206	408	29,125	SH		DFND	1	0	29,125	0
General Electric	Common	369604103	24	3,480	SH		DFND	1	0	3,480	0
General Electric	Common	369604103	8	1,200	SH		DFND	1	0	1,200	0
Globus Medical, Inc.	Common	379577208	138	2,900	SH		DFND	2	0	2,900	0
Heritage NOLA Bancorp Inc.	Common	42727P108	90	9,000	SH		DFND	1	0	9,000	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	2,030	36,531	SH		DFND	2	0	36,531	0
International Business Machines	Common	459200101	517	4,284	SH		DFND	1	0	4,284	0
International Gaming Technologies	Common	G4863A108	67	7,500	SH		DFND	1	0	7,500	0
International Gaming Technologies	Common	G4863A108	890	100,000	SH		DFND	2	0	100,000	0
Johnson & Johnson	Common	478160104	714	5,080	SH		DFND	1	0	5,080	0
Johnson & Johnson	Common	478160104	309	2,200	SH		DFND	1	0	2,200	0
JP Morgan Chase	Common	46625H100	1,340	14,250	SH		DFND	1	0	14,250	0
JP Morgan Chase	Common	46625H100	828	8,800	SH		DFND	1	0	8,800	0
Kadmon Holdings, Inc.	Common	48283N106	2,241	437,600	SH		DFND	2	0	437,600	0
Kimberly Clark Corporation	Common	494368103	848	6,000	SH		DFND	1	0	6,000	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	3,196	210,000	SH		DFND	2	0	210,000	0
KKR & Co. Inc.	Common	48251W104	5,558	180,000	SH		DFND	2	0	180,000	0
Krystal Biotech, Inc.	Common	501147102	293	7,079	SH		DFND	2	0	7,079	0
Legacy Housing Corporation	Common	52472M101	71	5,000	SH		DFND	1	0	5,000	0
Legacy Housing Corporation	Common	52472M101	57	4,000	SH		DFND	1	0	4,000	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	29,327	262,198	SH		DFND	2	0	262,198	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	1,007	9,000	SH		DFND	1	0	9,000	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	206	1,843	SH		DFND	1	0	1,843	0
LKQ Corporation	Common	501889208	3,930	150,000	SH		DFND	2	0	150,000	0
MPLX LP	Common	55336V100	1,728	100,000	SH		DFND	2	0	100,000	0
Macquarie Infrastructure Corporation	Common	55608B105	101	3,300	SH		DFND	1	0	3,300	0
Macquarie Infrastructure Corporation	Common	55608B105	302	9,850	SH		DFND	1	0	9,850	0
Medtronics	Common	G5960L103	96	1,050	SH		DFND	1	0	1,050	0
Merck & Co. Inc.	Common	58993Y105	62	800	SH		DFND	1	0	800	0
Merck & Co. Inc.	Common	58993Y105	39	500	SH		DFND	1	0	500	0
Microsoft Corporation	Common	594918104	81	400	SH		DFND	1	0	400	0
Microsoft Corporation	Common	594918104	204	1,000	SH		DFND	1	0	1,000	0
Mondelez Int'l Inc.	Common	609207105	148	2,900	SH		DFND	1	0	2,900	0
Mondelez Int'l Inc.	Common	609207105	665	13,000	SH		DFND	1	0	13,000	0
Occidental Pete Corp	Common	674599105	31	1,700	SH		DFND	1	0	1,700	0
Occidental Pete Corp	Common	674599105	23	1,273	SH		DFND	1	0	1,273	0
Peoples United Financial	Common	712704105	17	1,500	SH		DFND	1	0	1,500	0
Pfizer Inc.	Common	717081103	1,010	30,900	SH		DFND	1	0	30,900	0
Pfizer Inc.	Common	717081103	3,303	101,000	SH		DFND	1	0	101,000	0
Protara Therapeutics, Inc.	Common	74365U107	112	3,835	SH		DFND	2	0	3,835	0
Quotient Limited	Common	G73268107	959	129,527	SH		DFND	2	0	129,527	0
Radius Health Inc.	Common	750469207	587	43,034	SH		DFND	2	0	43,034	0
RMR Group Inc.	Common	74967R106	0	16	SH		DFND	1	0	16	0
Relmada Therapeutics, Inc.	Common	75955J402	134	3,000	SH		DFND	2	0	3,000	0
Ryman Hospitality Ppty Inc.	Common	78377T107	14	400	SH		DFND	1	0	400	0
Ryman Hospitality Ppty Inc.	Common	78377T107	415	12,000	SH		DFND	1	0	12,000	0
Sculptor Capital Management	Common	811246107	3	200	SH		DFND	1	0	200	0
Service Ppty Trust	Common	81761L102	7	1,000	SH		DFND	1	0	1,000	0
South Street Corporation	Common	840441109	74	1,548	SH		DFND	1	0	1,548	0
South Street Corporation	Common	840441109	25	534	SH		DFND	1	0	534	0
Starwood Ppty	Common	85571B105	6	400	SH		DFND	1	0	400	0
Stericycle, Inc.	Common	858912108	15,063	269,083	SH		DFND	2	0	269,083	0
Strongbridge Biopharma PLC	Common	G85347105	1,119	296,037	SH		DFND	2	0	296,037	0
TG Therapeutics Inc.	Common	88322Q108	234	12,000	SH		DFND	2	0	12,000	0
The Kraft Heinz Company	Common	500754106	97	3,035	SH		DFND	1	0	3,035	0
The Kraft Heinz Company	Common	500754106	38	1,199	SH		DFND	1	0	1,199	0
Total SA	Common	89151E109	91	2,360	SH		DFND	1	0	2,360	0
Total SA	Common	89151E109	19	500	SH		DFND	1	0	500	0
Trillium Therapeutics Inc.	Common	89620X506	2,138	264,225	SH		DFND	2	0	264,225	0
uniQure N.V.	Common	N90064101	917	20,358	SH		DFND	2	0	20,358	0
Upland Software, Inc.	Common	91544A109	14,130	406,500	SH		DFND	2	0	406,500	0
Valley National Bancorp	Common	919794107	73	9,280	SH		DFND	1	0	9,280	0
Valley National Bancorp	Common	919794107	25	3,200	SH		DFND	1	0	3,200	0
Verizon Communications Inc.	Common	92343V104	73	1,320	SH		DFND	1	0	1,320	0
Verizon Communications Inc.	Common	92343V104	937	16,991	SH		DFND	1	0	16,991	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	165	14,947	SH		DFND	2	0	14,947	0
Viking Therapeutics, Inc.	Common	92686J106	1,573	218,102	SH		DFND	2	0	218,102	0
WABTEC	Common	929740108	1	17	SH		DFND	1	0	17	0
WABTEC	Common	929740108	0	6	SH		DFND	1	0	6	0
WP Carey	Common	92936U109	406	6,000	SH		DFND	1	0	6,000	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,119	169,000	SH		DFND	2	0	169,000	0
Zogenix, Inc.	Common	98978L204	2,852	105,607	SH		DFND	2	0	105,607	0