Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	2,870	32,769	SH		DFND	2	32,769	0	0
AbbVie Inc.	Common	00287Y109	438	5,000	SH		DFND	1	5,000	0	0
AC Immune SA	Common	H00263105	26	5,309	SH		DFND	2	5,309	0	0
ADMA Biologics, Inc.	Common	000899104	156	65,157	SH		DFND	2	65,157	0	0
Alexion Pharamaceuticals, Inc.	Common	015351109	1,373	12,000	SH		DFND	2	12,000	0	0
Alerian MLP	Common	00162Q452	2	120	SH		DFND	1	120	0	0
Alimera Sciences, Inc.	Common	016259103	390	80,194	SH		DFND	2	80,194	0	0
Alkermes PLC	Common	G01767105	630	38,000	SH		DFND	2	38,000	0	0
AllianceBernstein Holding PL Unit Ltd.	Common	01881G106	41	1,500	SH		DFND	1	1,500	0	0
AllianceBernstein Holding PL Unit Ltd.	Common	01881G106	1,325	49,000	SH		DFND	1	49,000	0	0
Alphabet Inc-Cl C	Common	02079K107	8,230	5,600	SH		DFND	2	5,600	0	0
ALX Oncology. Inc	Common	00166B105	113	3,000	SH		DFND	2	3,000	0	0
Apollo Global Management, Inc.	Common	03768E105	13,425	300,000	SH		DFND	2	300,000	0	0
Apple Inc.	Common	037833100	243	2,100	SH		DFND	1	2,100	0	0
Apple Inc.	Common	037833100	243	2,100	SH		DFND	1	2,100	0	0
AT&T Inc.	Common	00206R102	58	2,050	SH		DFND	1	2,050	0	0
AT&T Inc.	Common	00206R102	570	20,000	SH		DFND	1	20,000	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	1,983	134,600	SH		DFND	2	134,600	0	0
Bank Nova Scotia Halifax	Common	064149107	17	400	SH		DFND	1	400	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	1,365	397,361	SH		DFND	2	397,361	0	0
BioDelivery Sciences International, Inc.	Common	09060J106	1,798	481,930	SH		DFND	2	481,930	0	0
Bristol-Myers Squibb Company	Common	110122108	2,798	46,409	SH		DFND	2	46,409	0	0
Bristol-Myers Squibb Company - CVR	Common	110122157	12	5,200	SH		DFND	2	5,200	0	0
Calumet Specialty Products Partners, LP	Common	131476103	5,100	2,000,000	SH		DFND	2	2,000,000	0	0
Calumet Specialty Products Partners, LP	Common	131476103	51	20,000	SH		DFND	1	20,000	0	0
Canadian Natural Resources Inc.	Common	136385101	293	18,285	SH		DFND	1	18,285	0	0
Canadian Natural Resources Inc.	Common	136385101	220	13,750	SH		DFND	1	13,750	0	0
Capitol Federal Financial Inc.	Common	14057J101	54	5,800	SH		DFND	1	5,800	0	0
Cardiff Oncology, Inc.	Common	14147L108	71	5,000	SH		DFND	2	5,000	0	0
Check Cap Ltd.	Common	M2361E203	1	2,224	SH		DFND	2	2,224	0	0
ChemoCentryx, Inc.	Common	16383L106	361	6,587	SH		DFND	2	6,587	0	0
Chemours Co.	Common	163851108	15	720	SH		DFND	1	720	0	0
Chemours Co.	Common	163851108	9	440	SH		DFND	1	440	0	0
Cidara Therapeutics, Inc.	Common	171757107	1,160	407,061	SH		DFND	2	407,061	0	0
Coco Cola	Common	191216100	286	5,800	SH		DFND	1	5,800	0	0
Coco Cola	Common	191216100	375	7,600	SH		DFND	1	7,600	0	0
Coherus Biosciences, Inc.	Common	19249H103	1,825	99,493	SH		DFND	2	99,493	0	0
Collegium Pharmaceutical, Inc.	Common	19459J104	622	29,862	SH		DFND	2	29,862	0	0
Colony Cap Inc.	Common	19626G108	4	1,466	SH		DFND	1	1,466	0	0
Conagra Brands	Common	205887102	357	10,000	SH		DFND	1	10,000	0	0
Corteva Inc.	Common	22052L104	43	1,494	SH		DFND	1	1,494	0	0
Corteva Inc.	Common	22052L104	318	11,051	SH		DFND	1	11,051	0	0
Cousins Properties	Common	222795502	96	3,357	SH		DFND	1	3,357	0	0
Cytokinetics, Incorporated	Common	23282W605	343	15,837	SH		DFND	2	15,837	0	0
Dow Inc.	Common	260557103	70	1,494	SH		DFND	1	1,494	0	0
Dow Inc.	Common	260557103	500	10,624	SH		DFND	1	10,624	0	0
Dupont De Nemours Inc.	Common	26614N102	83	1,494	SH		DFND	1	1,494	0	0
Dupont De Nemours Inc.	Common	26614N102	589	10,624	SH		DFND	1	10,624	0	0
Eagle Materials	Common	26969P108	20	228	SH		DFND	1	228	0	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,241	275,348	SH		DFND	2	275,348	0	0
Eli Lilly Inc.	Common	532457108	44	300	SH		DFND	1	300	0	0
FibroGen, Inc.	Common	31572Q808	811	19,715	SH		DFND	2	19,715	0	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	11,991	700,000	SH		DFND	2	700,000	0	0
FNB Corporation	Common	302520101	60	8,905	SH		DFND	1	8,905	0	0
FS Bancorp	Common	30263Y104	87	2,117	SH		DFND	1	2,117	0	0
FS Bancorp	Common	30263Y104	60	1,460	SH		DFND	1	1,460	0	0
FS KKR Capital Corp.	Common	302635107	5,551	350,000	SH		DFND	2	350,000	0	0
FS KKR Capital Corp.	Common	302635107	255	16,050	SH		DFND	1	16,050	0	0
FS KKR Capital Corp.	Common	302635107	462	29,125	SH		DFND	1	29,125	0	0
General Electric	Common	369604103	22	3,480	SH		DFND	1	3,480	0	0
General Electric	Common	369604103	7	1,200	SH		DFND	1	1,200	0	0
Gilead Sciences, Inc.	Common	375558103	695	11,000	SH		DFND	2	11,000	0	0
Globus Medical, Inc.	Common	379577208	144	2,900	SH		DFND	2	2,900	0	0
Heritage NOLA Bancorp Inc.	Common	42727P108	97	9,000	SH		DFND	1	9,000	0	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	2,915	37,531	SH		DFND	2	37,531	0	0
International Business Machines	Common	459200101	521	4,284	SH		DFND	1	4,284	0	0
International Gaming Technologies	Common	G4863A108	1,113	100,000	SH		DFND	2	100,000	0	0
International Gaming Technologies	Common	G4863A108	83	7,500	SH		DFND	1	7,500	0	0
iShares Nasdaq Biotechnology ETF	Common	464287556	135	1,000	SH		DFND	2	1,000	0	0
Johnson & Johnson	Common	478160104	756	5,080	SH		DFND	1	5,080	0	0
Johnson & Johnson	Common	478160104	328	2,200	SH		DFND	1	2,200	0	0
JP Morgan Chase	Common	46625H100	1,372	14,250	SH		DFND	1	14,250	0	0
JP Morgan Chase	Common	46625H100	847	8,800	SH		DFND	1	8,800	0	0
Kadmon Holdings, Inc.	Common	48283N106	2,399	612,000	SH		DFND	2	612,000	0	0
Kimberly Clark Corporation	Common	494368103	886	6,000	SH		DFND	1	6,000	0	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	3,049	210,000	SH		DFND	2	210,000	0	0
KKR & Co. Inc.	Common	48251W104	3,434	100,000	SH		DFND	2	100,000	0	0
Krystal Biotech, Inc.	Common	501147102	305	7,079	SH		DFND	2	7,079	0	0
Legacy Housing Corporation	Common	52472M101	68	5,000	SH		DFND	1	5,000	0	0
Legacy Housing Corporation	Common	52472M101	55	4,000	SH		DFND	1	4,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	22,610	237,198	SH		DFND	2	237,198	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	858	9,000	SH		DFND	1	9,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	176	1,843	SH		DFND	1	1,843	0	0
LKQ Corporation	Common	501889208	4,160	150,000	SH		DFND	2	150,000	0	0
Midwest Holding Inc.	Common	59833J206	1,247	83,344	SH		DFND	2	83,344	0	0
MPLX LP	Common	55336V100	1,574	100,000	SH		DFND	2	100,000	0	0
Macquarie Infrastructure Corporation	Common	55608B105	89	3,300	SH		DFND	1	3,300	0	0
Macquarie Infrastructure Corporation	Common	55608B105	265	9,850	SH		DFND	1	9,850	0	0
Medtronics	Common	G5960L103	109	1,050	SH		DFND	1	1,050	0	0
Merck & Co. Inc.	Common	58993Y105	66	800	SH		DFND	1	800	0	0
Merck & Co. Inc.	Common	58993Y105	41	500	SH		DFND	1	500	0	0
Microsoft Corporation	Common	594918104	84	400	SH		DFND	1	400	0	0
Microsoft Corporation	Common	594918104	210	1,000	SH		DFND	1	1,000	0	0
Mondelez Int'l Inc.	Common	609207105	167	2,900	SH		DFND	1	2,900	0	0
Mondelez Int'l Inc.	Common	609207105	747	13,000	SH		DFND	1	13,000	0	0
Occidental Pete Corp	Common	674599105	17	1,700	SH		DFND	1	1,700	0	0
Occidental Pete Corp	Common	674599105	13	1,273	SH		DFND	1	1,273	0	0
Occidental Pete Corp wts exp 8/3/27	Common	674599162	0	212	SH		DFND	1	212	0	0
Occidental Pete Corp wts exp 8/3/27	Common	674599162	0	158	SH		DFND	1	158	0	0
Peoples United Financial	Common	712704105	15	1,500	SH		DFND	1	1,500	0	0
Pfizer Inc.	Common	717081103	1,134	30,900	SH		DFND	1	30,900	0	0
Pfizer Inc.	Common	717081103	3,707	101,000	SH		DFND	1	101,000	0	0
Protara Therapeutics, Inc.	Common	74365U107	134	7,948	SH		DFND	2	7,948	0	0
Radius Health Inc.	Common	750469207	545	48,034	SH		DFND	2	48,034	0	0
Relmada Therapeutics, Inc.	Common	75955J402	113	3,000	SH		DFND	2	3,000	0	0
RMR Group Inc.	Common	74967R106	0	16	SH		DFND	1	16	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	442	12,000	SH		DFND	1	12,000	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	15	400	SH		DFND	1	400	0	0
Sculptor Capital Management	Common	811246107	2	200	SH		DFND	1	200	0	0
Service Ppty Trust	Common	81761L102	8	1,000	SH		DFND	1	1,000	0	0
South Street Corporation	Common	840441109	75	1,548	SH		DFND	1	1,548	0	0
South Street Corporation	Common	840441109	26	534	SH		DFND	1	534	0	0
Starwood Ppty	Common	85571B105	6	400	SH		DFND	1	400	0	0
Stericycle, Inc.	Common	858912108	10,090	160,000	SH		DFND	2	160,000	0	0
Strongbridge Biopharma PLC	Common	G85347105	781	372,000	SH		DFND	2	372,000	0	0
TG Therapeutics Inc.	Common	88322Q108	1,359	50,773	SH		DFND	2	50,773	0	0
The Kraft Heinz Company	Common	500754106	91	3,035	SH		DFND	1	3,035	0	0
The Kraft Heinz Company	Common	500754106	36	1,199	SH		DFND	1	1,199	0	0
Total SA	Common	89151E109	81	2,360	SH		DFND	1	2,360	0	0
Total SA	Common	89151E109	17	500	SH		DFND	1	500	0	0
Trillium Therapeutics Inc.	Common	89620X506	2,504	176,215	SH		DFND	2	176,215	0	0
uniQure N.V.	Common	N90064101	1,142	31,000	SH		DFND	2	31,000	0	0
Upland Software, Inc.	Common	91544A109	15,325	406,500	SH		DFND	2	406,500	0	0
Vapotherm, Inc.	Common	922107107	1,421	49,000	SH		DFND	2	49,000	0	0
Valley National Bancorp	Common	919794107	64	9,280	SH		DFND	1	9,280	0	0
Valley National Bancorp	Common	919794107	22	3,200	SH		DFND	1	3,200	0	0
Verizon Communications Inc.	Common	92343V104	79	1,320	SH		DFND	1	1,320	0	0
Verizon Communications Inc.	Common	92343V104	1,011	16,991	SH		DFND	1	16,991	0	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	357	46,125	SH		DFND	2	46,125	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,269	218,102	SH		DFND	2	218,102	0	0
WABTEC	Common	929740108	1	17	SH		DFND	1	17	0	0
WABTEC	Common	929740108	0	6	SH		DFND	1	6	0	0
WP Carey	Common	92936U109	391	6,000	SH		DFND	1	6,000	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	1,959	177,000	SH		DFND	2	177,000	0	0
Zogenix, Inc.	Common	98978L204	2,021	112,707	SH		DFND	2	112,707	0	0