Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	2,975	27,769	SH		DFND	2	27,769	0	0
AbbVie Inc.	Common	00287Y109	536	5,000	SH		DFND	2	5,000	0	0
AC Immune SA	Common	H00263105	27	5,309	SH		DFND	2	5,309	0	0
ADMA Biologics, Inc.	Common	000899104	42	21,457	SH		DFND	2	21,457	0	0
Alexion Pharamaceuticals, Inc.	Common	015351109	1,648	10,545	SH		DFND	2	10,545	0	0
Alerian MLP	Common	00162Q452	3	120	SH		DFND	1	120	0	0
Alimera Sciences, Inc.	Common	016259202	338	80,194	SH		DFND	2	80,194	0	0
Alphabet Inc-Cl C	Common	02079K107	9,811	5,600	SH		DFND	2	5,600	0	0
ALX Oncology. Inc	Common	00166B105	276	3,200	SH		DFND	2	3,200	0	0
AllianceBernstein Holding PL Unit Ltd.	Common	01881G106	51	1,500	SH		DFND	1	1,500	0	0
AllianceBernstein Holding PL Unit Ltd.	Common	01881G106	1,655	49,000	SH		DFND	1	49,000	0	0
Apollo Global Management, Inc.	Common	03768E105	14,694	300,000	SH		DFND	2	300,000	0	0
Apple Inc.	Common	037833100	279	2,100	SH		DFND	1	2,100	0	0
AT&T Inc.	Common	00206R102	59	2,050	SH		DFND	1	2,050	0	0
AT&T Inc.	Common	00206R102	575	20,000	SH		DFND	1	20,000	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	2,455	177,540	SH		DFND	2	177,540	0	0
Avadel Pharmaceuticals plc	Common	05337M104	581	86,916	SH		DFND	2	86,916	0	0
Axovant Gene Therapeutic, Ltd	Common	G0750W104	111	40,000	SH		DFND	2	40,000	0	0
Bank Nova Scotia Halifax	Common	064149107	22	400	SH		DFND	1	400	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	1,635	219,461	SH		DFND	2	219,461	0	0
BioDelivery Sciences International, Inc.	Common	09060J106	1,555	370,230	SH		DFND	2	370,230	0	0
Bristol-Myers Squibb Company	Common	110122108	3,251	52,409	SH		DFND	2	52,409	0	0
Bristol-Myers Squibb Company - CVR	Common	110122157	45	64,720	SH		DFND	2	64,720	0	0
Calumet Specialty Products Partners, LP	Common	131476103	8,216	2,625,000	SH		DFND	2	2,625,000	0	0
Calumet Specialty Products Partners, LP	Common	131476103	63	20,000	SH		DFND	1	20,000	0	0
Canadian Natural Resources Inc.	Common	136385101	440	18,285	SH		DFND	1	18,285	0	0
Canadian Natural Resources Inc.	Common	136385101	96	4,000	SH		DFND	1	4,000	0	0
Capitol Investment Corp. V	Common	14064F209	2,575	250,000	SH		DFND	2	250,000	0	0
Capitol Federal S&L	Common	14057J101	73	5,800	SH		DFND	1	5,800	0	0
Check Cap Ltd.	Common	M2361E203	1	2,224	SH		DFND	2	2,224	0	0
Chemours Co.	Common	163851108	18	720	SH		DFND	1	720	0	0
Chemours Co.	Common	163851108	11	440	SH		DFND	1	440	0	0
Cidara Therapeutics, Inc.	Common	171757107	831	415,308	SH		DFND	2	415,308	0	0
Coca Cola	Common	191216100	318	5,800	SH		DFND	1	5,800	0	0
Coca Cola	Common	191216100	417	7,600	SH		DFND	1	7,600	0	0
Coherus Biosciences, Inc.	Common	19249H103	1,767	101,655	SH		DFND	2	101,655	0	0
Colony Cap Inc.	Common	19626G108	7	1,466	SH		DFND	1	1,466	0	0
Conagra Brands	Common	205887102	363	10,000	SH		DFND	1	10,000	0	0
Constellation Phamaceuticals, Inc.	Common	210373106	950	33,000	SH		DFND	2	33,000	0	0
Corveta Inc.	Common	22052L104	58	1,494	SH		DFND	1	1,494	0	0
Corveta Inc.	Common	22052L104	428	11,051	SH		DFND	1	11,051	0	0
Cousins Properties	Common	222795502	112	3,357	SH		DFND	1	3,357	0	0
CTI BioPharma Corp.	Common	12648L601	64	20,000	SH		DFND	2	20,000	0	0
Danimer Scientific, Inc.	Common	236272100	11,755	500,000	SH		DFND	2	500,000	0	0
DFP Healthcare Acquistions Corp.	Common	23343Q209	11	1,000	SH		DFND	2	1,000	0	0
Dow Inc.	Common	260557103	83	1,494	SH		DFND	1	1,494	0	0
Dow Inc.	Common	260557103	590	10,624	SH		DFND	1	10,624	0	0
Dupont De Nemours Inc.	Common	26614N102	106	1,494	SH		DFND	1	1,494	0	0
Dupont De Nemours Inc.	Common	26614N102	755	10,624	SH		DFND	1	10,624	0	0
Eagle Materials	Common	26969P108	23	228	SH		DFND	1	228	0	0
Eastern Bankshares Inc	Common	27627N105	3,099	190,000	SH		DFND	2	190,000	0	0
Eastern Bankshares Inc	Common	27627N105	163	10,000	SH		DFND	1	10,000	0	0
Editas Medicine Inc.	Common	28106W103	421	6,000	SH		DFND	2	6,000	0	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	3,626	295,035	SH		DFND	2	295,035	0	0
Eli Lilly Inc.	Common	532457108	51	300	SH		DFND	1	300	0	0
FibroGen, Inc.	Common	31572Q808	371	10,000	SH		DFND	2	10,000	0	0
FNB Corporation	Common	302520101	85	8,905	SH		DFND	1	8,905	0	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	16,422	700,000	SH		DFND	2	700,000	0	0
FS Bancorp	Common	30263Y104	116	2,117	SH		DFND	1	2,117	0	0
FS Bancorp	Common	30263Y104	80	1,460	SH		DFND	1	1,460	0	0
FS KKR Capital Corp.	Common	302635206	5,796	350,000	SH		DFND	2	350,000	0	0
FS KKR Capital Corp.	Common	302635206	266	16,050	SH		DFND	1	16,050	0	0
FS KKR Capital Corp.	Common	302635206	482	29,125	SH		DFND	1	29,125	0	0
General Electric	Common	369604103	38	3,480	SH		DFND	1	3,480	0	0
General Electric	Common	369604103	13	1,200	SH		DFND	1	1,200	0	0
Gilead Sciences, Inc.	Common	375558103	3,778	64,842	SH		DFND	2	64,842	0	0
Globus Medical, Inc.	Common	379577208	302	4,631	SH		DFND	2	4,631	0	0
Heritage NOLA Bancorp Inc.	Common	42727P108	110	9,000	SH		DFND	1	9,000	0	0
Horizon Aquistion Corporation	Common	G46049105	2,105	210,100	SH		DFND	2	210,100	0	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	3,117	42,614	SH		DFND	2	42,614	0	0
International Business Machines	Common	459200101	539	4,284	SH		DFND	1	4,284	0	0
International Gaming Technologies	Common	G4863A108	1,694	100,000	SH		DFND	2	100,000	0	0
International Gaming Technologies	Common	G4863A108	127	7,500	SH		DFND	1	7,500	0	0
iPath Series B S&P 500 VIX Short-Term Fut	Common	06746P621	3,358	200,000	SH		DFND	2	200,000	0	0
iShares Nasdaq Biotechnology ETF	Common	464287556	151	1,000	SH		DFND	2	1,000	0	0
Johnson & Johnson	Common	478160104	799	5,080	SH		DFND	1	5,080	0	0
Johnson & Johnson	Common	478160104	157	1,000	SH		DFND	1	1,000	0	0
JP Morgan Chase	Common	46625H100	1,811	14,250	SH		DFND	1	14,250	0	0
JP Morgan Chase	Common	46625H100	727	5,720	SH		DFND	1	5,720	0	0
Kadmon Holdings, Inc.	Common	48283N106	2,913	702,000	SH		DFND	2	702,000	0	0
Kimberly Clark Corporation	Common	494368103	809	6,000	SH		DFND	1	6,000	0	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	3,757	210,000	SH		DFND	2	210,000	0	0
KKR & Co. Inc.	Common	48251W104	4,049	100,000	SH		DFND	2	100,000	0	0
Leap Therapeutics, Inc.	Common	52187K101	22	9,700	SH		DFND	2	9,700	0	0
Legacy Housing Corporation	Common	52472M101	76	5,000	SH		DFND	1	5,000	0	0
Legacy Housing Corporation	Common	52472M101	60	4,000	SH		DFND	1	4,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	23,589	237,198	SH		DFND	2	237,198	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	895	9,000	SH		DFND	1	9,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	183	1,843	SH		DFND	1	1,843	0	0
LKQ Corporation	Common	501889208	4,229	120,000	SH		DFND	2	120,000	0	0
Longview Aquisition Corp.	Common	543195101	364	18,380	SH		DFND	2	18,380	0	0
Marinus Pharmaceutical, Inc.	Common	56854Q200	305	25,000	SH		DFND	2	25,000	0	0
Macquarie Infrastructure Corporation	Common	55608B105	124	3,300	SH		DFND	1	3,300	0	0
Macquarie Infrastructure Corporation	Common	55608B105	370	9,850	SH		DFND	1	9,850	0	0
Medtronics	Common	G5960L103	123	1,050	SH		DFND	1	1,050	0	0
Merck & Co. Inc.	Common	58993Y105	65	800	SH		DFND	1	800	0	0
Merck & Co. Inc.	Common	58993Y105	41	500	SH		DFND	1	500	0	0
Microsoft Corporation	Common	594918104	89	400	SH		DFND	1	400	0	0
Microsoft Corporation	Common	594918104	222	1,000	SH		DFND	1	1,000	0	0
Midwest Holdings Inc.	Common	59833J206	7,705	143,621	SH		DFND	2	143,621	0	0
Mondelez Int'l Inc.	Common	609207105	170	2,900	SH		DFND	1	2,900	0	0
Mondelez Int'l Inc.	Common	609207105	760	13,000	SH		DFND	1	13,000	0	0
MPLX LP	Common	55336V100	2,165	100,000	SH		DFND	2	100,000	0	0
Occidental Pete Corp	Common	674599105	29	1,700	SH		DFND	1	1,700	0	0
Occidental Pete Corp	Common	674599105	22	1,273	SH		DFND	1	1,273	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	5	212	SH		DFND	1	212	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	3	158	SH		DFND	1	158	0	0
Peoples United Financial	Common	712704105	19	1,500	SH		DFND	1	1,500	0	0
Pfizer Inc.	Common	717081103	1,137	30,900	SH		DFND	1	30,900	0	0
Pfizer Inc.	Common	717081103	3,276	89,000	SH		DFND	1	89,000	0	0
Protara Therapeutics, Inc.	Common	74365U107	348	14,369	SH		DFND	2	14,369	0	0
Quotient Technology Inc.	Common	749119103	471	50,000	SH		DFND	2	50,000	0	0
Radius Health Inc.	Common	750469207	447	25,034	SH		DFND	2	25,034	0	0
Reinvent Technology Partners	Common	G7483N129	2,037	176,226	SH		DFND	2	176,226	0	0
Relmada Therapeutics, Inc.	Common	75955J402	96	3,000	SH		DFND	2	3,000	0	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND	1	16	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	27	400	SH		DFND	1	400	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	813	12,000	SH		DFND	1	12,000	0	0
Sculptor Capital Management	Common	811246107	3	200	SH		DFND	1	200	0	0
Service Ppty Trust	Common	81761L102	11	1,000	SH		DFND	1	1,000	0	0
South Street Corporation	Common	840441109	112	1,548	SH		DFND	1	1,548	0	0
South Street Corporation	Common	840441109	39	534	SH		DFND	1	534	0	0
Starwood Ppty	Common	85571B105	8	400	SH		DFND	1	400	0	0
Strongbridge Biopharma PLC	Common	BY25XL9US	647	266,194	SH		DFND	2	266,194	0	0
TG Therapeutics Inc.	Common	88322Q108	2,641	50,773	SH		DFND	2	50,773	0	0
Trillium Therapeutics Inc.	Common	89620X506	2,570	174,699	SH		DFND	2	174,699	0	0
The Kraft Heinz Company	Common	500754106	105	3,035	SH		DFND	1	3,035	0	0
The Kraft Heinz Company	Common	500754106	42	1,199	SH		DFND	1	1,199	0	0
Total SA	Common	89151E109	99	2,360	SH		DFND	1	2,360	0	0
Total SA	Common	89151E109	21	500	SH		DFND	1	500	0	0
uniQure N.V.	Common	N90064101	1,265	35,000	SH		DFND	2	35,000	0	0
Upland Software, Inc.	Common	91544A109	18,654	406,500	SH		DFND	2	406,500	0	0
Valley National Bancorp	Common	919794107	90	9,280	SH		DFND	1	9,280	0	0
Valley National Bancorp	Common	919794107	31	3,200	SH		DFND	1	3,200	0	0
Vapotherm, Inc.	Common	922107107	1,316	49,000	SH		DFND	2	49,000	0	0
Verizon Communications	Common	92343V104	78	1,320	SH		DFND	1	1,320	0	0
Verizon Communications	Common	92343V104	998	16,991	SH		DFND	1	16,991	0	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	881	76,585	SH		DFND	2	76,585	0	0
Viatris Inc.	Common	92556V106	5	80	SH		DFND	1	80	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,228	218,102	SH		DFND	2	218,102	0	0
WABTEC	Common	929740108	1	17	SH		DFND	1	17	0	0
WABTEC	Common	929740108	0	6	SH		DFND	1	6	0	0
WP Carey	Common	92936U109	423	6,000	SH		DFND	1	6,000	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	3,076	200,000	SH		DFND	2	200,000	0	0
Zogenix, Inc.	Common	98978L204	2,253	112,707	SH		DFND	2	112,707	0	0