Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	2,139	19,769	SH		DFND	2	19,769	0	0
AbbVie Inc.	Common	00287Y109	541	5,000	SH		DFND	1	5,000	0	0
African Gold Acquistion Corp.	Common	G0112R116	5,928	600,000	SH		DFND	2	600,000	0	0
African Gold Acquistion Corp.	Common	G0112R116	178	18,000	SH		DFND	1	18,000	0	0
Alerian MLP	Common	00162Q452	4	120	SH		DFND	1	120	0	0
Alimera Sciences, Inc.	Common	016259202	559	58,108	SH		DFND	2	58,108	0	0
Alphabet Inc-Cl C	Common	02079K107	11,584	5,600	SH		DFND	2	5,600	0	0
ALX Oncology Holdings Inc	Common	01166B105	236	3,200	SH		DFND	2	3,200	0	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	60	1,500	SH		DFND	1	1,500	0	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	1,960	49,000	SH		DFND	1	49,000	0	0
Apollo Global Management, Inc.	Common	03768E105	14,103	300,000	SH		DFND	2	300,000	0	0
Apple Inc.	Common	037833100	257	2,100	SH		DFND	1	2,100	0	0
ASLAN Pharmaceuticals Limited	Common	04522R101	1,465	437,412	SH		DFND	2	437,412	0	0
AT&T Inc.	Common	00206R102	2	50	SH		DFND	1	50	0	0
AT&T Inc.	Common	00206R102	605	20,000	SH		DFND	1	20,000	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	2,011	154,840	SH		DFND	2	154,840	0	0
Avadel Pharmaceuticals plc	Common	05337M104	2,467	272,845	SH		DFND	2	272,845	0	0
Bank Nova Scotia Halifax	Common	064149107	25	400	SH		DFND	1	400	0	0
B. Riley Principal 150 Merger Corp.	Common	05601V202	1,730	172,963	SH		DFND	2	172,963	0	0
B. Riley Principal 150 Merger Corp.	Common	05601V202	30	3,000	SH		DFND	1	3,000	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	312	30,703	SH		DFND	2	30,703	0	0
Bristol-Myers Squibb Company	Common	110122108	3,245	51,409	SH		DFND	2	51,409	0	0
Brookline Capital Acq Corp. Warrants	Common	11374E112	23	2,000	SH		DFND	2	2,000	0	0
Brookline Capital Acquisition Corp.	Common	11374E104	39	4,000	SH		DFND	2	4,000	0	0
Butterfly Network, Inc.	Common	124155102	309	18,380	SH		DFND	2	18,380	0	0
Calumet Specialty Products Partners, LP	Common	131476103	17,080	2,800,000	SH		DFND	2	2,800,000	0	0
Calumet Specialty Products Partners, LP	Common	131476103	275	45,000	SH		DFND	1	45,000	0	0
Canadian Natural Resources Inc.	Common	136385101	564	18,285	SH		DFND	1	18,285	0	0
Canadian Natural Resources Inc.	Common	136385101	123	4,000	SH		DFND	1	4,000	0	0
Capitol Investment Corp. V	Common	14064F100	2,525	250,000	SH		DFND	2	250,000	0	0
Capitol Investment Corp. V Warrants	Common	14064F118	958	83,333	SH		DFND	2	83,333	0	0
Capitol Federal S&L	Common	14057J101	156	5,800	SH		DFND	1	5,800	0	0
Carparts.com Inc.	Common	14427M107	53	3,700	SH		DFND	1	3,700	0	0
Cidara Therapeutics, Inc.	Common	171757107	1,105	415,308	SH		DFND	2	415,308	0	0
Chemours Co	Common	163851108	13	480	SH		DFND	1	480	0	0
Chemours Co	Common	163851108	12	440	SH		DFND	1	440	0	0
Coca Cola	Common	191216100	306	5,800	SH		DFND	1	5,800	0	0
Coca Cola	Common	191216100	401	7,600	SH		DFND	1	7,600	0	0
Coherus Biosciences, Inc.	Common	19249H103	1,456	99,655	SH		DFND	2	99,655	0	0
Colony Cap Inc.	Common	19626G108	10	1,466	SH		DFND	1	1,466	0	0
Colony Cap Inc.	Common	19626G108	71	11,000	SH		DFND	1	11,000	0	0
Conagra Brands	Common	205887102	376	10,000	SH		DFND	1	10,000	0	0
Constellation Pharmaceuticals, Inc.	Common	210373106	2,009	85,909	SH		DFND	2	85,909	0	0
Corteva Inc.	Common	22052L104	46	982	SH		DFND	1	982	0	0
Corteva Inc.	Common	22052L104	515	11,051	SH		DFND	1	11,051	0	0
Cousins Properties	Common	222795502	119	3,357	SH		DFND	1	3,357	0	0
CTI BioPharma Corp.	Common	12648L601	58	20,000	SH		DFND	2	20,000	0	0
Curis, Inc.	Common	231269200	113	10,000	SH		DFND	2	10,000	0	0
Danimer Scientific, Inc.	Common	236272100	7,550	200,000	SH		DFND	2	200,000	0	0
Dow Inc.	Common	260557103	96	1,494	SH		DFND	1	1,494	0	0
Dow Inc.	Common	260557103	679	10,624	SH		DFND	1	10,624	0	0
Dupont De Nemours Inc.	Common	26614N102	115	1,494	SH		DFND	1	1,494	0	0
Dupont De Nemours Inc.	Common	26614N102	821	10,624	SH		DFND	1	10,624	0	0
Eagle Materials	Common	26969P108	31	228	SH		DFND	1	228	0	0
Eastern Bankshares Inc	Common	27627N105	193	10,000	SH		DFND	1	10,000	0	0
Eastern Bankshares Inc	Common	27627N105	3,665	190,000	SH		DFND	2	190,000	0	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,447	276,535	SH		DFND	2	276,535	0	0
Eli Lilly Inc.	Common	532457108	56	300	SH		DFND	1	300	0	0
FNB Corporation	Common	302520101	113	8,905	SH		DFND	1	8,905	0	0
Facebook Inc.	Common	30303M102	292	990	SH		DFND	1	990	0	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	14,095	500,000	SH		DFND	2	500,000	0	0
FS Bancorp	Common	30263Y104	142	2,117	SH		DFND	1	2,117	0	0
FS Bancorp	Common	30263Y104	98	1,460	SH		DFND	1	1,460	0	0
FS KKR Capital Corp.	Common	302635206	6,941	350,000	SH		DFND	2	350,000	0	0
FS KKR Capital Corp.	Common	302635206	318	16,050	SH		DFND	1	16,050	0	0
FS KKR Capital Corp.	Common	302635206	578	29,125	SH		DFND	1	29,125	0	0
Full House Resort Inc.	Common	359678109	426	50,000	SH		DFND	2	50,000	0	0
Galapagos NV	Common	36315X101	77	1,000	SH		DFND	2	1,000	0	0
General Electric	Common	369604103	30	2,280	SH		DFND	1	2,280	0	0
General Electric	Common	369604103	16	1,200	SH		DFND	1	1,200	0	0
Gilead Sciences, Inc.	Common	375558103	3,292	50,942	SH		DFND	2	50,942	0	0
Glass Houses Acquisition Corp.	Common	37714P202	5,015	500,000	SH		DFND	2	500,000	0	0
Globus Medical, Inc.	Common	379577208	286	4,631	SH		DFND	2	4,631	0	0
HealthCor Catalio Acquisition Corp.	Common	G44125105	40	4,000	SH		DFND	2	4,000	0	0
Heritage NOLA Bancorp Inc.	Common	42727P108	122	9,000	SH		DFND	1	9,000	0	0
Horizon Aquistion Corporation	Common	G46049105	2,076	210,100	SH		DFND	2	210,100	0	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	3,738	40,614	SH		DFND	2	40,614	0	0
Ibere Pharmaceuticals	Common	G46843127	355	36,000	SH		DFND	2	36,000	0	0
Immunovant Inc.	Common	45258J102	547	34,100	SH		DFND	2	34,100	0	0
Independence Holdings Corp Units	Common	G4761A119	95	9,500	SH		DFND	1	9,500	0	0
International Business Machines	Common	459200101	571	4,284	SH		DFND	1	4,284	0	0
International Gaming Technologies	Common	G4863A108	120	7,500	SH		DFND	1	7,500	0	0
International Gaming Technologies	Common	G4863A108	1,605	100,000	SH		DFND	2	100,000	0	0
iShares Nasdaq Biotechnology ETF	Common	464287556	151	1,000	SH		DFND	2	1,000	0	0
Johnson & Johnson	Common	478160104	835	5,080	SH		DFND	1	5,080	0	0
Johnson & Johnson	Common	478160104	164	1,000	SH		DFND	1	1,000	0	0
JP Morgan Chase	Common	46625H100	1,484	9,750	SH		DFND	1	9,750	0	0
JP Morgan Chase	Common	46625H100	871	5,720	SH		DFND	1	5,720	0	0
Jumia Technologies AG	Common	48138M105	202	5,700	SH		DFND	1	5,700	0	0
Kadmon Holdings, Inc.	Common	48283N106	2,964	762,000	SH		DFND	2	762,000	0	0
Kairos Acquisition Corp.	Common	G52110114	2,546	261,374	SH		DFND	2	261,374	0	0
Kairos Acquisition Corp Units	Common	G52110122	145	14,500	SH		DFND	1	14,500	0	0
Kairos Acquisition Corp. Warrants	Common	G52110106	1,503	130,687	SH		DFND	2	130,687	0	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	4,244	210,000	SH		DFND	2	210,000	0	0
Kimberly Clark Corporation	Common	494368103	834	6,000	SH		DFND	1	6,000	0	0
KKR & Co. Inc.	Common	48251W104	4,885	100,000	SH		DFND	2	100,000	0	0
Legacy Housing Corporation	Common	52472M101	89	5,000	SH		DFND	1	5,000	0	0
Legacy Housing Corporation	Common	52472M101	71	4,000	SH		DFND	1	4,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	11,434	75,000	SH		DFND	2	75,000	0	0
Live Oak Mobility Aquisition Corp.	Common	538126202	3,594	360,152	SH		DFND	2	360,152	0	0
Longview Acquisition Corp II	Common	54319Q204	642	63,900	SH		DFND	2	63,900	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q200	933	60,266	SH		DFND	2	60,266	0	0
Macquarie Infrastructure Corporation	Common	55608B105	105	3,300	SH		DFND	1	3,300	0	0
Macquarie Infrastructure Corporation	Common	55608B105	313	9,850	SH		DFND	1	9,850	0	0
Medicus Science Acquisition, Corp.	Common	G5960S116	1,970	200,000	SH		DFND	2	200,000	0	0
Merck & Co. Inc.	Common	58933Y105	62	800	SH		DFND	1	800	0	0
Merck & Co. Inc.	Common	58933Y105	39	500	SH		DFND	1	500	0	0
Medtronics	Common	G5960L103	124	1,050	SH		DFND	1	1,050	0	0
Microsoft Corporation	Common	594918104	94	400	SH		DFND	1	400	0	0
Microsoft Corporation	Common	594918104	236	1,000	SH		DFND	1	1,000	0	0
Midwest Holding Inc.	Common	59833J206	7,499	150,000	SH		DFND	2	150,000	0	0
Millendo Therapeutics, Inc.	Common	60040X103	165	137,900	SH		DFND	2	137,900	0	0
Mondelez Int'l Inc.	Common	609207105	170	2,900	SH		DFND	1	2,900	0	0
Mondelez Int'l Inc.	Common	609207105	761	13,000	SH		DFND	1	13,000	0	0
Occidental Pete Corp	Common	674599105	30	1,114	SH		DFND	1	1,114	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	5	212	SH		DFND	1	212	0	0
Occidental Pete Corp	Common	674599105	34	1,273	SH		DFND	1	1,273	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	3	158	SH		DFND	1	158	0	0
Peoples United Financial	Common	712704105	27	1,500	SH		DFND	1	1,500	0	0
Pfizer Inc.	Common	717081103	1,120	30,900	SH		DFND	1	30,900	0	0
Pfizer Inc.	Common	717081103	3,224	89,000	SH		DFND	1	89,000	0	0
Poseida Therapeutics, Inc.	Common	73730P108	282	29,566	SH		DFND	2	29,566	0	0
Protara Therapeutics, Inc.	Common	74365U107	226	14,369	SH		DFND	2	14,369	0	0
Quotient Technology Inc.	Common	749119103	817	50,000	SH		DFND	2	50,000	0	0
Relmada Therapeutics, Inc.	Common	75955J402	106	3,000	SH		DFND	2	3,000	0	0
Roth CH Acquisition III Co.	Common	77867Q201	1,000	100,000	SH		DFND	2	100,000	0	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND	1	16	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	31	400	SH		DFND	1	400	0	0
Ryman Hospitality Ppty Inc.	Common	78377T107	930	12,000	SH		DFND	1	12,000	0	0
Sailpoint Technologies	Common	78781P105	86	1,700	SH		DFND	1	1,700	0	0
Sculptor Capital Management	Common	811246107	4	200	SH		DFND	1	200	0	0
Seelos Therapeutics, Inc.	Common	81577F109	361	72,367	SH		DFND	2	72,367	0	0
Service Ppty Trust	Common	81761L102	12	1,000	SH		DFND	1	1,000	0	0
Sio Gene Therapies, Inc.	Common	829399104	183	70,000	SH		DFND	2	70,000	0	0
South Street Corporation	Common	840441109	122	1,548	SH		DFND	1	1,548	0	0
South Street Corporation	Common	840441109	42	534	SH		DFND	1	534	0	0
SPDR S&P Biotech ETF	Common	78464A870	515	3,800	SH		DFND	2	3,800	0	0
Starwood Ppty	Common	85571B105	10	400	SH		DFND	1	400	0	0
TG Therapeutics, Inc.	Common	88322Q108	2,505	51,973	SH		DFND	2	51,973	0	0
T-Mobil US Inc.	Common	872590104	88	700	SH		DFND	1	700	0	0
Tastemaker Acquisition Corp.	Common	876545104	1,948	200,000	SH		DFND	2	200,000	0	0
Tastemaker Acquisition Corp. Warrants	Common	876545112	1,150	100,000	SH		DFND	2	100,000	0	0
The Kraft Company	Common	500754106	108	2,702	SH		DFND	1	2,702	0	0
The Kraft Company	Common	500754106	48	1,199	SH		DFND	1	1,199	0	0
Total SA	Common	89151E109	91	1,960	SH		DFND	1	1,960	0	0
Total SA	Common	89151E109	23	500	SH		DFND	1	500	0	0
Trillium Therapeutics Inc.	Common	89620X506	2,134	198,699	SH		DFND	2	198,699	0	0
Twelve Seas Investment Company II	Common	90118T205	4,925	500,000	SH		DFND	2	500,000	0	0
Twelve Seas Investment Company II	Common	90118T205	148	15,000	SH		DFND	1	15,000	0	0
uniQure N.V.	Common	N90064101	1,407	41,766	SH		DFND	2	41,766	0	0
United Therapeutics Corporation	Common	91307C102	2,425	14,500	SH		DFND	2	14,500	0	0
Up Fintech Holdings	Common	91531W106	244	13,736	SH		DFND	1	13,736	0	0
Upland Software, Inc.	Common	91544A109	14,157	300,000	SH		DFND	2	300,000	0	0
Valley National Bancorp	Common	919794107	128	9,280	SH		DFND	1	9,280	0	0
Valley National Bancorp	Common	919794107	44	3,200	SH		DFND	1	3,200	0	0
Verizon Communications	Common	92343V104	42	720	SH		DFND	1	720	0	0
Verizon Communications	Common	92343V104	988	16,991	SH		DFND	1	16,991	0	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	1,188	78,424	SH		DFND	2	78,424	0	0
Viatris Inc.	Common	92556V106	3	248	SH		DFND	1	248	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,316	208,102	SH		DFND	2	208,102	0	0
WABTEC	Common	929740108	1	11	SH		DFND	1	11	0	0
WABTEC	Common	929740108	0	6	SH		DFND	1	6	0	0
WP Carey	Common	92936U109	425	6,000	SH		DFND	1	6,000	0	0
Warrior Technologies Acquisition Company	Common	936273200	248	25,000	SH		DFND	2	25,000	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,579	144,101	SH		DFND	2	144,101	0	0
Zogenix, Inc.	Common	98978L204	2,297	117,688	SH		DFND	2	117,688	0	0