Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	338	3,000	SH		DFND		2	3,000	0
AbbVie Inc.	Common	00287Y109	563	5,000	SH		DFND		1	5,000	0
African Gold Acquistion Corp.	Common	G0112R108	483	50,000	SH		DFND		2	50,000	0
African Gold Acquistion Corp.	Common	G0112R108	174	18,000	SH		DFND		1	18,000	0
African Gold Acquistion Corp. Warrants	Common	G0112R124	5,175	450,000	SH		DFND		2	450,000	0
African Gold Acquistion Corp. Warrants	Common	G0112R124	155	13,500	SH		DFND		1	13,500	0
Alerian MLP	Common	00162Q452	4	120	SH		DFND		1	120	0
Alimera Sciences, Inc.	Common	016259202	348	38,226	SH		DFND		2	38,226	0
Alphabet Inc-Cl C	Common	02079K107	14,035	5,600	SH		DFND		2	5,600	0
ALX Oncology Holdings Inc	Common	01166B105	175	3,200	SH		DFND		2	3,200	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	70	1,500	SH		DFND		1	1,500	0
AllianceBernstein Holdings PL Unit Ltd	Common	01881G106	2,281	49,000	SH		DFND		1	49,000	0
Apollo Global Management, Inc.	Common	03768E105	18,660	300,000	SH		DFND		2	300,000	0
Apple Inc.	Common	037833100	288	2,100	SH		DFND		1	2,100	0
ARC Resources Ltd	Common	00208D408	10	1,190	SH		DFND		1	1,190	0
ARC Resources Ltd	Common	00208D408	1	158	SH		DFND		1	158	0
ASLAN Pharmaceuticals Limited	Common	04522R101	1,578	478,186	SH		DFND		2	478,186	0
AT&T Inc.	Common	00206R102	1	50	SH		DFND		1	50	0
AT&T Inc.	Common	00206R102	576	20,000	SH		DFND		1	20,000	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	2,136	164,840	SH		DFND		2	164,840	0
Avadel Pharmaceuticals plc	Common	05337M104	2,052	304,922	SH		DFND		2	304,922	0
Bank Nova Scotia Halifax	Common	064149107	26	400	SH		DFND		1	400	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	1,686	172,963	SH		DFND		2	172,963	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	29	3,000	SH		DFND		1	3,000	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	10	1,000	SH		DFND		1	1,000	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	663	57,654	SH		DFND		2	57,654	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	11	999	SH		DFND		1	999	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	4	333	SH		DFND		1	333	0
B.Riley Principal 250 Merger Corp.	Common	05601V103	3,490	350,000	SH		DFND		2	350,000	0
Bristol-Myers Squibb Company	Common	110122108	2,901	43,409	SH		DFND		2	43,409	0
Brookline Capital Acq Corp. Warrants	Common	11374E112	23	2,000	SH		DFND		2	2,000	0
Brookline Capital Acquisition Corp.	Common	11374E104	40	4,000	SH		DFND		2	4,000	0
Butterfly Network, Inc.	Common	124155102	663	45,760	SH		DFND		2	45,760	0
Calumet Specialty Products Partners, LP	Common	131476103	21,285	3,098,300	SH		DFND		2	3,098,300	0
Calumet Specialty Products Partners, LP	Common	131476103	378	55,000	SH		DFND		1	55,000	0
Canadian Natural Resources Inc.	Common	136385101	663	18,285	SH		DFND		1	18,285	0
Canadian Natural Resources Inc.	Common	136385101	145	4,000	SH		DFND		1	4,000	0
Capitol Investment Corp. V Warrants	Common	14064F118	958	83,333	SH		DFND		2	83,333	0
Capitol Federal	Common	14057J101	45	3,800	SH		DFND		1	3,800	0
Carparts.com Inc.	Common	14427M107	75	3,700	SH		DFND		1	3,700	0
Cidara Therapeutics, Inc.	Common	171757107	839	415,308	SH		DFND		2	415,308	0
Chemours Co.	Common	163851108	17	480	SH		DFND		1	480	0
Chemours Co.	Common	163851108	15	440	SH		DFND		1	440	0
Coca-Cola	Common	191216100	314	5,800	SH		DFND		1	5,800	0
Coca-Cola	Common	191216100	411	7,600	SH		DFND		1	7,600	0
Coherus Biosciences, Inc.	Common	19249H103	1,378	99,655	SH		DFND		2	99,655	0
Conagra Brands	Common	205887102	364	10,000	SH		DFND		1	10,000	0
Coliseum Acquisition Corp.	Common	G2263T115	14,672	1,485,000	SH		DFND		2	1,485,000	0
Colombier Acquisition Corp	Common	19533H207	794	80,000	SH		DFND		2	80,000	0
Constellation Pharmaceuticals, Inc.	Common	210373106	3,107	91,909	SH		DFND		2	91,909	0
Corteva Inc.	Common	22052L104	44	982	SH		DFND		1	982	0
Corteva Inc.	Common	22052L104	490	11,051	SH		DFND		1	11,051	0
Cousins Properties	Common	222795502	123	3,357	SH		DFND		1	3,357	0
CRISPR Therapeutics AG	Common	H17182108	324	2,000	SH		DFND		2	2,000	0
CTI BioPharma Corp.	Common	12648L601	150	60,000	SH		DFND		2	60,000	0
Curis, Inc.	Common	231269200	81	10,000	SH		DFND		2	10,000	0
Danimer Scientific, Inc.	Common	236272100	5,010	200,000	SH		DFND		2	200,000	0
Digital Bridge Group	Common	25401T108	87	11,000	SH		DFND		1	11,000	0
Digital Bridge Group	Common	25401T108	12	1,466	SH		DFND		1	1,466	0
Dow Inc.	Common	260557103	95	1,494	SH		DFND		1	1,494	0
Dow Inc.	Common	260557103	672	10,624	SH		DFND		1	10,624	0
Dupont De Nemours Inc.	Common	26614N102	116	1,494	SH		DFND		1	1,494	0
Dupont De Nemours Inc.	Common	26614N102	822	10,624	SH		DFND		1	10,624	0
Eagle Materials	Common	26969P108	32	228	SH		DFND		1	228	0
Eastern Bankshares Inc	Common	27627N105	3,908	190,000	SH		DFND		2	190,000	0
Eastern Bankshares Inc	Common	27627N105	206	10,000	SH		DFND		1	10,000	0
Editas Medicine, Inc.	Common	28106W103	57	1,000	SH		DFND		2	1,000	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,441	286,554	SH		DFND		2	286,554	0
Eli Lilly Inc.	Common	532457108	69	300	SH		DFND		1	300	0
FNB Corporation	Common	302520101	110	8,905	SH		DFND		1	8,905	0
Facebook Inc.	Common	30303M102	344	990	SH		DFND		1	990	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	16,698	497,700	SH		DFND		2	497,700	0
FS Bancorp	Common	30263Y104	151	2,117	SH		DFND		1	2,117	0
FS Bancorp	Common	30263Y104	104	1,460	SH		DFND		1	1,460	0
FS KKR Capital Corp.	Common	302635206	7,529	350,000	SH		DFND		2	350,000	0
FS KKR Capital Corp.	Common	302635206	345	16,050	SH		DFND		1	16,050	0
FS KKR Capital Corp.	Common	302635206	626	29,125	SH		DFND		1	29,125	0
Galapagos NV	Common	36315X101	138	2,000	SH		DFND		2	2,000	0
General Electric	Common	369604103	31	2,280	SH		DFND		1	2,280	0
General Electric	Common	369604103	16	1,200	SH		DFND		1	1,200	0
Gilead Sciences, Inc.	Common	375558103	1,066	15,481	SH		DFND		2	15,481	0
Glass Houses Acquisition Corp.	Common	37714P103	4,815	500,000	SH		DFND		2	500,000	0
Glass Houses Acquisition Corp. Warrants	Common	37714P111	2,875	250,000	SH		DFND		2	250,000	0
Globus Medical, Inc.	Common	379577208	359	4,631	SH		DFND		2	4,631	0
HealthCor Catalio Acquisition Corp.	Common	G44125105	39	4,000	SH		DFND		2	4,000	0
Heritage NOLA Bancorp	Common	42727P108	128	9,000	SH		DFND		1	9,000	0
Horizon Acquistion Corporation	Common	G46044106	2,090	210,100	SH		DFND		2	210,100	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	2,996	32,000	SH		DFND		2	32,000	0
Ibere Pharmaceuticals	Common	G46843101	348	36,000	SH		DFND		2	36,000	0
Ibere Pharmaceuticals Warrants	Common	G46843119	207	18,000	SH		DFND		2	18,000	0
Immunovant Inc.	Common	45258J102	1,028	97,294	SH		DFND		2	97,294	0
Independence Holdings	Common	G4761A101	93	9,500	SH		DFND		1	9,500	0
Independence Holdings Wts	Common	G4761A127	22	1,900	SH		DFND		1	1,900	0
Innoviva, Inc.	Common	45781M101	641	47,798	SH		DFND		2	47,798	0
Inspired Entertainment, Inc.	Common	45782N108	1,275	100,000	SH		DFND		2	100,000	0
International Business Machines	Common	459200101	628	4,284	SH		DFND		1	4,284	0
International Gaming Technologies	Common	G4863A108	2,396	100,000	SH		DFND		2	100,000	0
International Gaming Technologies	Common	G4863A108	180	7,500	SH		DFND		1	7,500	0
Johnson & Johnson	Common	478160104	837	5,080	SH		DFND		1	5,080	0
Johnson & Johnson	Common	478160104	165	1,000	SH		DFND		1	1,000	0
JP Morgan Chase	Common	46625H100	1,936	12,450	SH		DFND		1	12,450	0
JP Morgan Chase	Common	46625H100	890	5,720	SH		DFND		1	5,720	0
Jumia Technologies AG	Common	48138M105	297	9,800	SH		DFND		1	9,800	0
Kadmon Holdings, Inc.	Common	48283N106	3,244	838,190	SH		DFND		2	838,190	0
Kairos Acquisition Corp.	Common	G52110114	3,210	330,963	SH		DFND		2	330,963	0
Kairos Acquisition Corp.	Common	G52110114	141	14,500	SH		DFND		1	14,500	0
Kairos Acquisition Corp. Warrants	Common	G52110106	1,602	139,278	SH		DFND		2	139,278	0
Kairos Acquisition Corp. Warrants	Common	G52110106	83	7,250	SH		DFND		1	7,250	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	4,173	210,000	SH		DFND		2	210,000	0
Kimberly Clark Corporation	Common	494368103	803	6,000	SH		DFND		1	6,000	0
KKR & Co. Inc.	Common	48251W104	5,924	100,000	SH		DFND		2	100,000	0
Legacy Housing Corporation	Common	52472M101	85	5,000	SH		DFND		1	5,000	0
Legacy Housing Corporation	Common	52472M101	68	4,000	SH		DFND		1	4,000	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	9,839	75,000	SH		DFND		2	75,000	0
Live Oak Mobility Aquisition Corp.	Common	538126103	3,529	360,152	SH		DFND		2	360,152	0
Live Oak Mobility Aquisition Corp. Wts	Common	538126111	828	72,030	SH		DFND		2	72,030	0
Longview Acquisition Corp II	Common	54319Q105	626	63,900	SH		DFND		2	63,900	0
Longview Acquisition Corp II Warrants	Common	54319Q113	147	12,780	SH		DFND		2	12,780	0
Marinus Pharmaceuticals, Inc.	Common	56854Q200	1,456	81,166	SH		DFND		2	81,166	0
Macquire Infrastructure Corp	Common	55608B105	126	3,300	SH		DFND		1	3,300	0
Macquire Infrastructure Corp	Common	55608B105	377	9,850	SH		DFND		1	9,850	0
Medicus Science Acquisition, Corp.	Common	G59605108	1,930	200,000	SH		DFND		2	200,000	0
Medicus Science Acquisition, Corp. Wts	Common	G5960S124	256	22,222	SH		DFND		2	22,222	0
Merck & Co. Inc.	Common	58933Y105	62	800	SH		DFND		1	800	0
Merck & Co. Inc.	Common	58933Y105	39	500	SH		DFND		1	500	0
Medtronics	Common	G5960L103	130	1,050	SH		DFND		1	1,050	0
Microsoft Corporation	Common	594918104	108	400	SH		DFND		1	400	0
Microsoft Corporation	Common	594918104	271	1,000	SH		DFND		1	1,000	0
Midwest Holding Inc.	Common	59833J206	6,470	165,000	SH		DFND		2	165,000	0
Mondelez Int'l Inc.	Common	609207105	182	2,900	SH		DFND		1	2,900	0
Mondelez Int'l Inc.	Common	609207105	812	13,000	SH		DFND		1	13,000	0
Occidental Pete Corp	Common	674599105	35	1,114	SH		DFND		1	1,114	0
Occidental Pete Corp	Common	674599105	40	1,273	SH		DFND		1	1,273	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	5	212	SH		DFND		1	212	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	3	158	SH		DFND		1	158	0
Organon & Co.	Common	68622V106	2	80	SH		DFND		1	80	0
Organon & Co.	Common	68622V106	2	50	SH		DFND		1	50	0
Peoples United Financial	Common	712704105	26	1,500	SH		DFND		1	1,500	0
Perrigo Company PLC	Common	G97822103	225	4,915	SH		DFND		2	4,915	0
Pershing Square Holdings, Ltd	Common	71531R109	6,259	275,000	SH		DFND		2	275,000	0
Pfizer Inc.	Common	717081103	1,210	30,900	SH		DFND		1	30,900	0
Pfizer Inc.	Common	717081103	3,485	89,000	SH		DFND		1	89,000	0
Poseida Therapeutics, Inc.	Common	73730P108	296	29,566	SH		DFND		2	29,566	0
Protara Therapeutics, Inc.	Common	74365U107	352	36,164	SH		DFND		2	36,164	0
Support.com, Inc.	Common	86858W200	3,345	866,700	SH	Put	DFND		2	866,700	0
Support.com, Inc.	Common	86858W200	1,911	495,200	SH	Put	DFND		2	495,200	0
Quotient Technology Inc.	Common	749119103	1,351	125,000	SH		DFND		2	125,000	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	3,351	6,000	SH		DFND		2	6,000	0
Relmada Therapeutics, Inc.	Common	75955J402	192	6,000	SH		DFND		2	6,000	0
Roth CH Acquisition III Co.	Common	77867Q102	987	100,000	SH		DFND		2	100,000	0
Roth CH Acquisition III Co. Warrants	Common	77867Q110	288	25,000	SH		DFND		2	25,000	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND		1	16	0
Ryman Hospitality Ppty Inc.	Common	78377T107	32	400	SH		DFND		1	400	0
Ryman Hospitality Ppty Inc.	Common	78377T107	948	12,000	SH		DFND		1	12,000	0
Sailpoint Technologies	Common	78781P105	87	1,700	SH		DFND		1	1,700	0
Sculptor Capital Management	Common	811246107	5	200	SH		DFND		1	200	0
Seelos Therapeutics, Inc.	Common	81577F109	191	72,367	SH		DFND		2	72,367	0
Service Ppty Trust	Common	81761L102	13	1,000	SH		DFND		1	1,000	0
Sio Gene Therapies, Inc.	Common	829399104	218	80,000	SH		DFND		2	80,000	0
South Street Corporation	Common	840441109	127	1,548	SH		DFND		1	1,548	0
South Street Corporation	Common	840441109	44	534	SH		DFND		1	534	0
SPDR S&P Biotech ETF	Common	78464A870	108	800	SH		DFND		2	800	0
Starwood Ppty	Common	85571B105	10	400	SH		DFND		1	400	0
Tastemaker Acquisition Corp.	Common	876545104	1,944	200,000	SH		DFND		2	200,000	0
Tastemaker Acquisition Corp. Warrants	Common	876545112	1,150	100,000	SH		DFND		2	100,000	0
Tempest Therapeutics, Inc.	Common	87978U108	155	13,833	SH		DFND		2	13,833	0
TG Therapeutics, Inc.	Common	88322Q108	1,954	50,373	SH		DFND		2	50,373	0
The Kraft Company	Common	500754106	110	2,702	SH		DFND		1	2,702	0
The Kraft Company	Common	500754106	49	1,199	SH		DFND		1	1,199	0
Total SA	Common	89151E109	89	1,960	SH		DFND		1	1,960	0
Total SA	Common	89151E109	23	500	SH		DFND		1	500	0
T-Mobil US Inc.	Common	872590104	101	700	SH		DFND		1	700	0
Trillium Therapeutics Inc.	Common	89620X506	1,927	198,699	SH		DFND		2	198,699	0
Twelve Seas Investment Company II	Common	90118T106	4,825	500,000	SH		DFND		2	500,000	0
Twelve Seas Investment Company II	Common	90118T106	145	15,000	SH		DFND		1	15,000	0
Twelve Seas Investment Company II Warrants	Common	90118T114	1,917	166,666	SH		DFND		2	166,666	0
Twelve Seas Investment Company II Warrants	Common	90118T114	58	5,000	SH		DFND		1	5,000	0
uniQure N.V.	Common	N90064101	1,440	46,766	SH		DFND		2	46,766	0
United Therapeutics Corporation	Common	91307C102	2,745	15,300	SH		DFND		2	15,300	0
Up Fintech Holdings	Common	91531W106	398	13,736	SH		DFND		1	13,736	0
Upland Software, Inc.	Common	91544A109	12,351	300,000	SH		DFND		2	300,000	0
Valley National Bancorp	Common	919794107	125	9,280	SH		DFND		1	9,280	0
Valley National Bancorp	Common	919794107	43	3,200	SH		DFND		1	3,200	0
Verizon Communications	Common	92343V104	40	720	SH		DFND		1	720	0
Verizon Communications	Common	92343V104	952	16,991	SH		DFND		1	16,991	0
Verrica Pharmaceuticals, Inc.	Common	92511W108	16	1,375	SH		DFND		2	1,375	0
Viatris Inc.	Common	92556V106	11	794	SH		DFND		1	794	0
Viking Therapeutics, Inc.	Common	92686J106	1,247	208,102	SH		DFND		2	208,102	0
WABTEC	Common	929740108	1	11	SH		DFND		1	11	0
WABTEC	Common	929740108	0	6	SH		DFND		1	6	0
WP Carey	Common	92936U109	448	6,000	SH		DFND		1	6,000	0
Warrior Technologies Acquisition Comp Wt	Common	936273119	144	12,500	SH		DFND		2	12,500	0
Warrior Technologies Acquisition Company	Common	936273101	242	25,000	SH		DFND		2	25,000	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,617	140,551	SH		DFND		2	140,551	0
Zogenix, Inc.	Common	98978L204	2,155	124,688	SH		DFND		2	124,688	0