Knott David M 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbbVie Inc.	Common	00287Y109	324	3,000	SH		DFND	2	3,000	0	0
AbbVie Inc.	Common	00287Y109	539	5,000	SH		DFND	1	5,000	0	0
Acceleron Pharma, Inc.	Common	00434H108	172	1,000	SH		DFND	2	1,000	0	0
African Gold Acquistion Corp. Warrants	Common	G0112R124	5,175	450,000	SH		DFND	2	450,000	0	0
African Gold Acquistion Corp. Warrants	Common	G0112R124	155	13,500	SH		DFND	1	13,500	0	0
African Gold Acquistion Corp.	Common	G0112R108	175	18,000	SH		DFND	1	18,000	0	0
Alerian MLP	Common	00162Q452	4	120	SH		DFND	1	120	0	0
Alimera Sciences, Inc.	Common	016259202	162	38,226	SH		DFND	2	38,226	0	0
AllianceBernstein Holdings PL Unit Ltd.	Common	01881G106	74	1,500	SH		DFND	1	1,500	0	0
AllianceBernstein Holdings PL Unit Ltd.	Common	01881G106	2,429	49,000	SH		DFND	1	49,000	0	0
Alphabet Inc-Cl C	Common	02079K107	14,926	5,600	SH		DFND	2	5,600	0	0
ALX Oncology Holdings Inc	Common	01166B105	236	3,200	SH		DFND	2	3,200	0	0
American Outdoor Brands	Common	028750109	25	1,024	SH		DFND	1	1,024	0	0
Apollo Global Management, Inc.	Common	03768E105	15,398	250,000	SH		DFND	2	250,000	0	0
Apple Inc.	Common	037833100	297	2,100	SH		DFND	1	2,100	0	0
ASLAN Pharmaceuticals Limited	Common	04522R101	851	478,186	SH		DFND	2	478,186	0	0
AT&T Inc.	Common	00206R102	3	125	SH		DFND	1	125	0	0
AT&T Inc.	Common	00206R102	540	20,000	SH		DFND	1	20,000	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	1,392	62,896	SH		DFND	2	62,896	0	0
Avadel Pharmaceuticals plc	Common	05337M104	2,958	301,864	SH		DFND	2	301,864	0	0
Bank Nova Scotia Halifax	Common	064149107	25	400	SH		DFND	1	400	0	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	29	3,000	SH		DFND	1	3,000	0	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	1,686	172,963	SH		DFND	2	172,963	0	0
B. Riley Principal 150 Merger Corp.	Common	05601V103	10	1,000	SH		DFND	1	1,000	0	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	663	57,654	SH		DFND	2	57,654	0	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	11	999	SH		DFND	1	999	0	0
B. Riley Principal 150 Merger Corp. Wts	Common	05601V111	4	333	SH		DFND	1	333	0	0
B.Riley Principal 250 Merger Corp.	Common	05602L104	3,395	350,000	SH		DFND	2	350,000	0	0
B.Riley Principal 250 Merger Corp. Wts.	Common	05602L112	1,342	116,666	SH		DFND	2	116,666	0	0
Bristol-Myers Squibb Company	Common	110122108	2,509	42,409	SH		DFND	2	42,409	0	0
Brookline Capital Acq Corp. Warrants	Common	11374E112	23	2,000	SH		DFND	2	2,000	0	0
Brookline Capital Acquisition Corp.	Common	11374E104	40	4,000	SH		DFND	2	4,000	0	0
Butterfly Network, Inc.	Common	124155102	478	45,760	SH		DFND	2	45,760	0	0
Calumet Specialty Products Partners, LP	Common	131476103	27,685	3,500,000	SH		DFND	2	3,500,000	0	0
Calumet Specialty Products Partners, LP	Common	131476103	534	67,500	SH		DFND	1	67,500	0	0
Canadian Natural Resources Inc.	Common	136385101	690	18,885	SH		DFND	1	18,885	0	0
Capitol Federal	Common	14057J101	46	4,000	SH		DFND	1	4,000	0	0
Carparts.com Inc.	Common	14427M107	58	3,700	SH		DFND	1	3,700	0	0
Cidara Therapeutics, Inc.	Common	171757107	930	415,308	SH		DFND	2	415,308	0	0
Chemours Co.	Common	163851108	14	480	SH		DFND	1	480	0	0
Chemours Co.	Common	163851108	13	440	SH		DFND	1	440	0	0
Coca Cola	Common	191216100	304	5,800	SH		DFND	1	5,800	0	0
Coca Cola	Common	191216100	399	7,600	SH		DFND	1	7,600	0	0
Codexis, Inc.	Common	192005106	233	10,000	SH		DFND	2	10,000	0	0
Coherus Biosciences, Inc.	Common	19249H103	1,648	102,555	SH		DFND	2	102,555	0	0
Coliseum Acquisition Corp	Common	G2263T123	9,563	984,835	SH		DFND	2	984,835	0	0
Coliseum Acquisition Corp. Wts	Common	G2263T107	5,693	495,000	SH		DFND	2	495,000	0	0
Colombier Acquisition Corp.	Common	19533H108	774	80,000	SH		DFND	2	80,000	0	0
Colombier Acquisition Corp. Wts.	Common	19533H116	307	26,666	SH		DFND	2	26,666	0	0
Conagra Brands	Common	205887102	339	10,000	SH		DFND	1	10,000	0	0
Corteva Inc.	Common	22052L104	43	1,024	SH		DFND	1	1,024	0	0
Corteva Inc.	Common	22052L104	465	11,051	SH		DFND	1	11,051	0	0
CRISPR Therapeutics AG	Common	H17182108	224	2,000	SH		DFND	2	2,000	0	0
CTI BioPharma Corp.	Common	12648L601	177	60,000	SH		DFND	2	60,000	0	0
Curis, Inc.	Common	231269200	78	10,000	SH		DFND	2	10,000	0	0
Danimer Scientific, Inc.	Common	236272100	3,268	200,000	SH		DFND	2	200,000	0	0
Digital Bridge Group	Common	25401T108	66	11,000	SH		DFND	1	11,000	0	0
Digital Bridge Group	Common	25401T108	9	1,466	SH		DFND	1	1,466	0	0
Dow Inc.	Common	260557103	88	1,536	SH		DFND	1	1,536	0	0
Dow Inc.	Common	260557103	612	10,624	SH		DFND	1	10,624	0	0
Dupont De Nemours Inc.	Common	26614N102	104	1,536	SH		DFND	1	1,536	0	0
Dupont De Nemours Inc.	Common	26614N102	722	10,624	SH		DFND	1	10,624	0	0
Doma Holdings, Inc. - Warrants	Common	25703A112	958	83,333	SH		DFND	2	83,333	0	0
Eagle Materials	Common	26969P108	30	228	SH		DFND	1	228	0	0
Eastern Bankshares Inc	Common	27627N105	3,857	190,000	SH		DFND	2	190,000	0	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	2,087	312,492	SH		DFND	2	312,492	0	0
Eli Lilly Inc.	Common	532457108	69	300	SH		DFND	1	300	0	0
Facebook Inc.	Common	30303M102	336	990	SH		DFND	1	990	0	0
FNB Bancorp	Common	302520101	103	8,905	SH		DFND	1	8,905	0	0
Fortress Trans & Infrastructure Inv. LLC	Common	34960P101	12,632	497,700	SH		DFND	2	497,700	0	0
FS Bancorp	Common	30263Y104	152	4,380	SH		DFND	1	4,380	0	0
FS Bancorp	Common	30263Y104	101	2,920	SH		DFND	1	2,920	0	0
FS KKR Capital Corp.	Common	302635206	3,408	154,650	SH		DFND	2	154,650	0	0
FS KKR Capital Corp.	Common	302635206	354	16,050	SH		DFND	1	16,050	0	0
FS KKR Capital Corp.	Common	302635206	642	29,125	SH		DFND	1	29,125	0	0
Galapagos NV	Common	36315X101	105	2,000	SH		DFND	2	2,000	0	0
Gilead Sciences, Inc.	Common	375558103	1,081	15,481	SH		DFND	2	15,481	0	0
General Electric	Common	369604103	31	300	SH		DFND	1	300	0	0
General Electric	Common	369604103	15	150	SH		DFND	1	150	0	0
Glass Houses Acquisition Corp.	Common	37714P103	4,890	500,000	SH		DFND	2	500,000	0	0
Glass Houses Acquisition Corp. Warrants	Common	37714P111	2,875	250,000	SH		DFND	2	250,000	0	0
Globus Medical, Inc.	Common	379577208	355	4,631	SH		DFND	2	4,631	0	0
Greenidge Generation Holdings Inc.	Common	39531G100	5,721	224,000	SH		DFND	2	224,000	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	75	2,937	SH	Put	DFND	2	2,937	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	932	36,487	SH	Put	DFND	2	36,487	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	431	16,885	SH	Put	DFND	2	16,885	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	281	11,000	SH	Put	DFND	2	11,000	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	562	22,000	SH	Put	DFND	2	22,000	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	140	5,500	SH	Put	DFND	2	5,500	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	6,385	250,000	SH	Put	DFND	2	250,000	0	0
Greenidge Generation Holdings Inc.	Common	39531G950	2,656	104,000	SH	Put	DFND	2	104,000	0	0
HealthCor Catalio Acquisition Corp.	Common	G44125105	40	4,000	SH		DFND	2	4,000	0	0
Heritiage NOLA Bancorp	Common	42727P108	139	9,000	SH		DFND	1	9,000	0	0
Horizon Acquistion Corporation	Common	G46049105	2,097	210,100	SH		DFND	2	210,100	0	0
Horizon Therapeutics Public Ltd. Company	Common	G46188101	2,191	20,000	SH		DFND	2	20,000	0	0
Ibere Pharmaceuticals	Common	G46843101	349	36,000	SH		DFND	2	36,000	0	0
Ibere Pharmaceuticals Warrants	Common	G46843119	207	18,000	SH		DFND	2	18,000	0	0
Immunovant Inc.	Common	45258J102	370	42,600	SH		DFND	2	42,600	0	0
Incyte Corporation	Common	45337C102	1,821	26,475	SH		DFND	2	26,475	0	0
Independence Holdings	Common	G4761A101	93	9,500	SH		DFND	1	9,500	0	0
Independence Holdings Warrants	Common	G4761A127	22	1,900	SH		DFND	1	1,900	0	0
Innoviva, Inc.	Common	45781M101	1,926	115,269	SH		DFND	2	115,269	0	0
Interantional Gaming Technologies	Common	G4863A108	79	3,000	SH		DFND	1	3,000	0	0
Interantional Gaming Technologies	Common	G4863A108	197	7,500	SH		DFND	1	7,500	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	99	4,000	SH		DFND	2	4,000	0	0
Johnson & Johnson	Common	478160104	840	5,200	SH		DFND	1	5,200	0	0
JP Morgan Chase	Common	46625H100	2,000	12,220	SH		DFND	1	12,220	0	0
JP Morgan Chase	Common	46625H100	740	4,520	SH		DFND	1	4,520	0	0
Jumia Technologies AG	Common	48138M105	182	9,800	SH		DFND	1	9,800	0	0
Kadmon Holdings, Inc.	Common	48283N106	8,618	989,450	SH		DFND	2	989,450	0	0
Kairos Acquisition Corp.	Common	G52110114	3,200	330,963	SH		DFND	2	330,963	0	0
Kairos Acquisition Corp.	Common	G52110114	140	14,500	SH		DFND	1	14,500	0	0
Kairos Acquisition Corp. Warrants	Common	G52110106	1,602	139,278	SH		DFND	2	139,278	0	0
Kairos Acquisition Corp. Warrants	Common	G52110106	83	7,250	SH		DFND	1	7,250	0	0
Kennedy-Wilson Holdings, Inc.	Common	489398107	4,393	210,000	SH		DFND	2	210,000	0	0
Kimberly Clark Corporation	Common	494368103	795	6,000	SH		DFND	1	6,000	0	0
KKR & Co. Inc.	Common	48251W104	3,044	50,000	SH		DFND	2	50,000	0	0
Legacy Housing Corporation	Common	52472M101	90	5,000	SH		DFND	1	5,000	0	0
Legacy Housing Corporation	Common	52472M101	72	4,000	SH		DFND	1	4,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	10,449	75,000	SH		DFND	2	75,000	0	0
Live Oak Mobility Aquisition Corp.	Common	538126103	3,483	360,152	SH		DFND	2	360,152	0	0
Live Oak Mobility Aquisition Corp. Wts	Common	538126111	828	72,030	SH		DFND	2	72,030	0	0
Longview Acquisition Corp II	Common	54319Q105	632	63,900	SH		DFND	2	63,900	0	0
Longview Acquisition Corp II Warrants	Common	54319Q113	147	12,780	SH		DFND	2	12,780	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q200	924	81,166	SH		DFND	2	81,166	0	0
Macquire Infrastructure Corp	Common	556088105	142	3,500	SH		DFND	1	3,500	0	0
Macquire Infrastructure Corp	Common	556088105	400	9,850	SH		DFND	1	9,850	0	0
Medicus Science Acquisition, Corp.	Common	G5960S108	1,950	200,000	SH		DFND	2	200,000	0	0
Medicus Science Acquisition, Corp. Wts	Common	G5960S124	256	22,222	SH		DFND	2	22,222	0	0
Merck & Co. Inc.	Common	58933Y105	73	975	SH		DFND	1	975	0	0
Merck & Co. Inc.	Common	58933Y105	38	500	SH		DFND	1	500	0	0
Medtronics	Common	G5960L103	132	1,050	SH		DFND	1	1,050	0	0
Microsoft Corporation	Common	594918104	113	400	SH		DFND	1	400	0	0
Microsoft Corporation	Common	594918104	282	1,000	SH		DFND	1	1,000	0	0
Midwest Holding Inc.	Common	59833J206	6,613	170,000	SH		DFND	2	170,000	0	0
Mondelez Int'l Inc.	Common	609207105	175	3,000	SH		DFND	1	3,000	0	0
Mondelez Int'l Inc.	Common	609207105	756	13,000	SH		DFND	1	13,000	0	0
Occidental Pete Corp	Common	674599105	33	1,114	SH		DFND	1	1,114	0	0
Occidental Pete Corp	Common	674599105	20	687	SH		DFND	1	687	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	5	212	SH		DFND	1	212	0	0
Occidental Pete Corp Wts exp 8/3/27	Common	674599162	2	85	SH		DFND	1	85	0	0
Organon & Co.	Common	68622V106	3	97	SH		DFND	1	97	0	0
Organon & Co.	Common	68622V106	2	50	SH		DFND	1	50	0	0
Peoples United Financial	Common	712704105	26	1,500	SH		DFND	1	1,500	0	0
Pfizer Inc.	Common	717081103	1,372	31,900	SH		DFND	1	31,900	0	0
Pfizer Inc.	Common	717081103	3,553	82,600	SH		DFND	1	82,600	0	0
Poseida Therapeutics, Inc.	Common	73730P108	216	29,566	SH		DFND	2	29,566	0	0
Protara Therapeutics, Inc.	Common	74365U107	252	36,479	SH		DFND	2	36,479	0	0
Quotient Technology Inc.	Common	749119103	728	125,000	SH		DFND	2	125,000	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	3,631	6,000	SH		DFND	2	6,000	0	0
Relmada Therapeutics, Inc.	Common	75955J402	157	6,000	SH		DFND	2	6,000	0	0
Roth CH Acquisition III Co.	Common	77867Q102	994	100,000	SH		DFND	2	100,000	0	0
Roth CH Acquisition III Co. Warrants	Common	77867Q110	288	25,000	SH		DFND	2	25,000	0	0
RMR Group Inc.	Common	74967R106	1	16	SH		DFND	1	16	0	0
Ryman Hospitality Ppty Inc	Common	78377T107	33	400	SH		DFND	1	400	0	0
Ryman Hospitality Ppty Inc	Common	78377T107	1,004	12,000	SH		DFND	1	12,000	0	0
Sailpoint Technologies	Common	78781P105	73	1,700	SH		DFND	1	1,700	0	0
Schmitt Industries	Common	806870200	11	2,500	SH		DFND	1	2,500	0	0
Sculptor Capital Management	Common	811246107	6	200	SH		DFND	1	200	0	0
Seelos Therapeutics, Inc.	Common	81577F109	174	72,367	SH		DFND	2	72,367	0	0
Service Ppty Trust	Common	81761L102	11	1,000	SH		DFND	1	1,000	0	0
Sio Gene Therapies, Inc.	Common	829399104	174	80,000	SH		DFND	2	80,000	0	0
Smith & Wesson Brands	Common	831754106	85	4,097	SH		DFND	1	4,097	0	0
South Street Corporation	Common	840441109	120	1,601	SH		DFND	1	1,601	0	0
South Street Corporation	Common	840441109	40	534	SH		DFND	1	534	0	0
SPDR S&P Biotech ETF	Common	78464A870	101	800	SH		DFND	2	800	0	0
Starwood Ppty	Common	85571B105	10	400	SH		DFND	1	400	0	0
Tastemaker Acquisition Corp.	Common	876545104	1,972	200,000	SH		DFND	2	200,000	0	0
Tastemaker Acquisition Corp. Warrants	Common	876545112	1,150	100,000	SH		DFND	2	100,000	0	0
Tempest Therapeutics, Inc.	Common	879784108	78	5,359	SH		DFND	2	5,359	0	0
TG Therapeutics, Inc.	Common	88322Q108	1,650	49,592	SH		DFND	2	49,592	0	0
The Kraft Company	Common	500754106	101	2,732	SH		DFND	1	2,732	0	0
Total SA	Common	89151E109	96	2,000	SH		DFND	1	2,000	0	0
Total SA	Common	89151E109	24	500	SH		DFND	1	500	0	0
T-Mobil US Inc.	Common	872590104	89	700	SH		DFND	1	700	0	0
Trillium Therapeutics Inc.	Common	89620X506	3,489	198,699	SH		DFND	2	198,699	0	0
Twelve Seas Investment Company II	Common	90118T106	4,858	500,000	SH		DFND	2	500,000	0	0
Twelve Seas Investment Company II	Common	90118T106	146	15,000	SH		DFND	1	15,000	0	0
Twelve Seas Investment Company II Warrants	Common	90118T114	1,917	166,666	SH		DFND	2	166,666	0	0
Twelve Seas Investment Company II Warrants	Common	90118T114	58	5,000	SH		DFND	1	5,000	0	0
uniQure N.V.	Common	N90064101	1,497	46,766	SH		DFND	2	46,766	0	0
United Therapeutics Corporation	Common	91307C102	2,824	15,300	SH		DFND	2	15,300	0	0
UP Fintech Holdings	Common	91531W106	145	13,736	SH		DFND	1	13,736	0	0
Upland Software, Inc.	Common	91544A109	10,032	300,000	SH		DFND	2	300,000	0	0
Valley National Bancorp	Common	919794107	128	9,600	SH		DFND	1	9,600	0	0
Valley National Bancorp	Common	919794107	43	3,200	SH		DFND	1	3,200	0	0
Verizon Communications	Common	92343V104	54	1,000	SH		DFND	1	1,000	0	0
Verizon Communications	Common	92343V104	918	16,991	SH		DFND	1	16,991	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,307	208,102	SH		DFND	2	208,102	0	0
WABTEC	Common	929740108	1	11	SH		DFND	1	11	0	0
WABTEC	Common	929740108	1	6	SH		DFND	1	6	0	0
WP Carey	Common	92936U109	438	6,000	SH		DFND	1	6,000	0	0
Warrior Technologies Acquisition Comp Wt	Common	936273119	144	12,500	SH		DFND	2	12,500	0	0
Warrior Technologies Acquisition Company	Common	936273101	245	25,000	SH		DFND	2	25,000	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	1,444	94,488	SH		DFND	2	94,488	0	0
Zogenix, Inc.	Common	98978L204	1,894	124,688	SH		DFND	2	124,688	0	0
Zymeworks Inc.	Common	98985W102	116	4,000	SH		DFND	2	4,000	0	0