Navidea Biopharmaceuticals (NAVB) 10-Q 2009 Q3 Quarterly report

Exhibit 32.1

CERTIFICATION OF PERIODIC FINANCIAL REPORT PURSUANT TO

SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002, 18 U.S.C. SECTION 1350

The undersigned hereby certifies that he is the duly appointed and acting Chief Executive Officer of Neoprobe Corporation (the “Company”) and hereby further certifies as follows:

(1)           The periodic report containing financial statements to which this certificate is an exhibitfully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2)           The information contained in the periodic report to which this certificate is an exhibitfairly presents, in all material respects, the financial condition and results of operations of the Company.

In witness whereof, the undersigned has executed and delivered this certificate as of the date set forth opposite his signature below.

November 16, 2009	/s/ David C. Bupp
	David C. Bupp
	President and Chief Executive Officer