Celgene (CELG) 10-Q 26 Jul 18 2018 Q2 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	6 Months Ended
	Jun. 30, 2018	Jul. 23, 2018
Document and Entity Information
Entity Registrant Name	CELGENE CORP /DE/
Entity Central Index Key	816,284
Current Fiscal Year End Date	--12-31
Entity Filer Category	Large Accelerated Filer
Document Type	10-Q
Document Period End Date	Jun. 30, 2018
Document Fiscal Year Focus	2,018
Document Fiscal Period Focus	Q2
Amendment Flag	false
Entity Common Stock, Shares Outstanding		703,363,010

CONSOLIDATED STATEMENTS OF INCO

CONSOLIDATED STATEMENTS OF INCOME - USD ($) shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Revenue:
Total revenue	$ 3,814	$ 3,271	$ 7,352	$ 6,233
Expenses:
Cost of goods sold (excluding amortization of acquired intangible assets)	126	111	261	224
Research and development	1,251	835	3,454	1,830
Selling, general and administrative	790	939	1,654	1,559
Amortization of acquired intangible assets	127	88	214	170
Acquisition related charges (income) and restructuring, net	34	(13)	65	26
Total costs and expenses	2,328	1,960	5,648	3,809
Operating income	1,486	1,311	1,704	2,424
Other income and (expense):
Interest and investment income, net	9	24	22	39
Interest (expense)	(192)	(126)	(358)	(253)
Other income (expense), net	4	(31)	969	(18)
Income before income taxes	1,307	1,178	2,337	2,192
Income tax provision	262	77	446	159
Net income	$ 1,045	$ 1,101	$ 1,891	$ 2,033
Net income per common share:
Basic (in dollars per share)	$ 1.46	$ 1.41	$ 2.58	$ 2.61
Diluted (in dollars per share)	$ 1.43	$ 1.36	$ 2.52	$ 2.51
Weighted average shares:
Basic (in shares)	716.1	780.4	732.1	779.7
Diluted (in shares)	732.6	811.7	750.6	811.5
Net product sales
Revenue:
Total revenue	$ 3,808	$ 3,259	$ 7,339	$ 6,211
Other revenue
Revenue:
Total revenue	$ 6	$ 12	$ 13	$ 22

CONSOLIDATED STATEMENTS OF COMP

CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Statement of Comprehensive Income [Abstract]
Net income	$ 1,045	$ 1,101	$ 1,891	$ 2,033
Other comprehensive income (loss):
Foreign currency translation adjustments	(28)	31	(12)	41
Net unrealized gains (losses) related to cash flow hedges:
Unrealized holding gains (losses)	226	(198)	127	(266)
Tax benefit		7	1	7
Unrealized holding gains (losses), net of tax	226	(191)	128	(259)
Reclassification adjustment for losses (gains) included in net income	13	(79)	40	(163)
Tax (benefit)	(1)	(1)	(1)	(2)
Reclassification adjustment for losses (gains) included in net income, net of tax	12	(80)	39	(165)
Excluded component related to cash flow hedges:
Amortization of excluded component (gains)	(7)	(3)	(15)	(5)
Reclassification of realized excluded component losses to net income	6	0	17	0
Net reclassification adjustment included in net income	(1)	(3)	2	(5)
Net unrealized gains (losses) on available-for-sale debt / marketable securities (see Note 1):
Unrealized holding gains (losses)	0	2	(9)	229
Tax (expense) benefit	0	(1)	2	(81)
Unrealized holding gains (losses), net of tax	0	1	(7)	148
Reclassification adjustment for losses included in net income	0	34	18	34
Tax (benefit)	0	(13)	(4)	(13)
Reclassification adjustment for losses included in net income, net of tax	0	21	14	21
Total other comprehensive income (loss)	209	(221)	164	(219)
Comprehensive income	$ 1,254	$ 880	$ 2,055	$ 1,814

CONSOLIDATED BALANCE SHEETS

CONSOLIDATED BALANCE SHEETS - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Current assets:
Cash and cash equivalents	$ 1,503	$ 7,013
Debt securities available-for-sale	79	3,219
Equity investments with readily determinable fair values	1,828	1,810
Accounts receivable, net of allowances of $37 and $36 as of June 30, 2018 and December 31, 2017, respectively	2,064	1,921
Inventory	555	541
Other current assets	824	388
Total current assets	6,853	14,892
Property, plant and equipment, net	1,292	1,070
Intangible assets, net	16,470	8,436
Goodwill	8,004	4,866
Other non-current assets	825	877
Total assets	33,444	30,141
Current liabilities:
Short-term borrowings and current portion of long-term debt	1,497	0
Accounts payable	294	305
Accrued expenses and other current liabilities	2,615	2,523
Income taxes payable	32	84
Current portion of deferred revenue	64	75
Total current liabilities	4,502	2,987
Deferred revenue, net of current portion	63	34
Income taxes payable	2,368	2,490
Deferred income tax liabilities	2,771	1,327
Other non-current liabilities	556	544
Long-term debt, net of discount	19,754	15,838
Total liabilities	30,014	23,220
Commitments and Contingencies (See Note 15)
Stockholders’ Equity:
Preferred stock, $.01 par value per share, 5.0 million shares authorized; none outstanding as of June 30, 2018 and December 31, 2017	0	0
Common stock, $.01 par value per share, 1,150.0 million shares authorized; issued 977.5 million and 971.7 million shares as of June 30, 2018 and December 31, 2017, respectively	10	10
Common stock in treasury, at cost; 274.9 million and 212.4 million shares as of June 30, 2018 and December 31, 2017, respectively	(25,700)	(20,243)
Additional paid-in capital	13,835	13,806
Retained earnings	15,404	13,061
Accumulated other comprehensive (loss) income	(119)	287
Total stockholders’ equity	3,430	6,921
Total liabilities and stockholders’ equity	$ 33,444	$ 30,141

CONSOLIDATED BALANCE SHEETS (Pa

CONSOLIDATED BALANCE SHEETS (Parenthetical) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Statement of Financial Position [Abstract]
Accounts receivable, allowances (in dollars)	$ 37	$ 36
Preferred stock, par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized	5,000,000	5,000,000
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized	1,150,000,000	1,150,000,000
Common stock, shares issued	977,500,000	971,700,000
Common stock, treasury (in shares)	274,900,000	212,400,000

CONSOLIDATED STATEMENTS OF CASH

CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Millions	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017
Cash flows from operating activities:
Net income	$ 1,891	$ 2,033
Adjustments to reconcile net income to net cash provided by operating activities:
Depreciation	79	66
Amortization	217	174
Impairment charges	27	50
Deferred income taxes	(43)	(186)
Change in value of contingent consideration and success payments	(23)	26
Net loss on sales of debt securities available-for-sale	18	0
Net (gain) on equity investments with and without a readily determinable fair value	(954)	(15)
Share-based compensation expense	492	323
Share-based employee benefit plan expense	20	22
Derivative instruments	(8)	(60)
Other, net	(10)	(46)
Change in current assets and liabilities, excluding the effect of acquisitions and disposals:
Accounts receivable	(157)	(75)
Inventory	(14)	(32)
Other operating assets	(323)	(184)
Accounts payable and other operating liabilities	(144)	219
Income tax payable	(178)	33
Payment of contingent consideration	(22)	0
Deferred revenue	20	1
Net cash provided by operating activities	904	2,469
Cash flows from investing activities:
Proceeds from sales of debt securities available-for-sale	3,240	2,057
Purchases of debt securities available-for-sale	(110)	(3,411)
Capital expenditures	(168)	(132)
Proceeds from sales of equity investment securities	55	27
Purchases of equity investment securities	(155)	(156)
Payments for acquisition of business, net of cash acquired	(8,648)	0
Net cash (used in) investing activities	(5,786)	(1,615)
Cash flows from financing activities:
Payment for treasury shares	(6,096)	(811)
Proceeds from short-term borrowing	4,929	0
Principal repayments on short-term borrowing	(3,934)	0
Proceeds from issuance of long-term debt	4,452	0
Payment of contingent consideration	(40)	0
Net proceeds from share-based compensation arrangements	46	387
Net cash (used in) financing activities	(643)	(424)
Effect of currency rate changes on cash and cash equivalents	15	60
Net (decrease) increase in cash and cash equivalents	(5,510)	490
Cash and cash equivalents at beginning of period	7,013	6,170
Cash and cash equivalents at end of period	1,503	6,660
Supplemental schedule of non-cash investing and financing activity:
Change in net unrealized loss (gain) on debt securities available-for-sale/marketable securities available-for-sale	9	(229)
Supplemental disclosure of cash flow information:
Interest paid	300	262
Income taxes paid	$ 786	$ 333

Nature of Business, Basis of Pr

Nature of Business, Basis of Presentation and New Accounting Standards	6 Months Ended
	Jun. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of Business, Basis of Presentation and New Accounting Standards	Nature of Business, Basis of Presentation and New Accounting Standards Celgene Corporation, together with its subsidiaries (collectively “we,” “our,” “us,” “Celgene” or the “Company”), is an integrated global biopharmaceutical company engaged primarily in the discovery, development and commercialization of innovative therapies for the treatment of cancer and inflammatory diseases through next-generation solutions in protein homeostasis, immuno-oncology, epigenetics, immunology and neuro-inflammation. Celgene Corporation was incorporated in the State of Delaware in 1986. Our commercial stage products include REVLIMID ® , POMALYST ® /IMNOVID ® , OTEZLA ® , ABRAXANE ® , VIDAZA ® , azacitidine for injection (generic version of VIDAZA ® ), THALOMID ® (sold as THALOMID ® or Thalidomide Celgene ® outside of the U.S.) and IDHIFA ® . In addition, we earn revenue from other product sales and licensing arrangements. The consolidated financial statements include the accounts of Celgene Corporation and its subsidiaries. Investments in limited partnerships and interests where we have an equity interest of 50% or less and do not otherwise have a controlling financial interest are accounted for by one of three methods: the equity method, as an investment without a readily determinable fair value or as an investment with a readily determinable fair value. We operate in a single segment engaged in the discovery, development, manufacturing, marketing, distribution and sale of innovative therapies for the treatment of cancer and inflammatory diseases. Consistent with our operational structure, our Chief Executive Officer (CEO), as the chief operating decision maker, manages and allocates resources at the global corporate level. Our global research and development organization is responsible for discovery of new drug candidates and supports development and registration efforts for potential future products. Our global supply chain organization is responsible for the manufacturing and supply of products. Regional/therapeutic area commercial organizations market, distribute and sell our products. The business is also supported by global corporate staff functions. Managing and allocating resources at the global corporate level enables our CEO to assess both the overall level of resources available and how to best deploy these resources across functions, therapeutic areas, regional commercial organizations and research and development projects in line with our overarching long-term corporate-wide strategic goals, rather than on a product or franchise basis. Consistent with this decision-making process, our CEO uses consolidated, single-segment financial information for purposes of evaluating performance, allocating resources, setting incentive compensation targets, as well as forecasting future period financial results. The preparation of the consolidated financial statements requires management to make estimates and assumptions that affect reported amounts and disclosures. Actual results could differ from those estimates. We are subject to certain risks and uncertainties related to, among other things, product development, regulatory approval, market acceptance, scope of patent and proprietary rights, competition, outcome of legal and governmental proceedings, credit risk, technological change and product liability. Interim results may not be indicative of the results that may be expected for the full year. In the opinion of management, these unaudited consolidated financial statements include all normal and recurring adjustments considered necessary for a fair presentation of these interim unaudited consolidated financial statements. Certain prior year amounts have been reclassified to conform to the current year's presentation. During the first quarter of 2018, we adopted Accounting Standards Update No. 2016-01, “Financial Instruments-Overall: Recognition and Measurement of Financial Assets and Financial Liabilities” (ASU 2016-01). As such, we have recast our previously reported marketable securities available-for-sale of $5,029 million on our Consolidated Balance Sheet as of December 31, 2017 to conform to the current year presentation as shown in the table below. There were no changes to total current assets or total assets as a result of this reclassification. December 31, 2017 As Reported As Revised Marketable securities available-for-sale $ 5,029 N/A Debt securities available-for-sale N/A $ 3,219 Equity investments with readily determinable fair values N/A 1,810 In addition, as a result of adopting ASU 2016-01, we have also recast certain activity within our previously reported Consolidated Statement of Cash Flows for the six-month period ended June 30, 2017 to conform to the current year presentation as shown in the table below. There were no changes to Net cash provided by operating activities, Net cash (used in) investing activities and Net cash (used in) financing activities as a result of this reclassification. Six-Month Period Ended June 30, 2017 As Reported As Revised Purchases of marketable securities available-for-sale $ (3,482 ) N/A Purchases of investment securities (85 ) N/A Purchases of debt securities available-for-sale N/A $ (3,411 ) Purchases of equity investment securities N/A (156 ) Proceeds from sales of marketable securities available-for-sale 2,070 N/A Proceeds from sales of investment securities 14 N/A Proceeds from sales of debt securities available-for-sale N/A 2,057 Proceeds from sales of equity investment securities N/A 27 In addition, in August 2017, the Financial Accounting Standards Board (FASB) issued Accounting Standards Update No. 2017-12, "Derivatives and Hedging: Targeted Improvements to Accounting for Hedging Activities" (ASU 2017-12), which we adopted on August 31, 2017, with an initial application date as of January 1, 2017. As previously disclosed in our Annual Report on Form 10-K for the year ended December 31, 2017 (2017 Annual Report on Form 10-K), during the nine-month period ended September 30, 2017, the Company recorded pre-tax income of $48 million and $37 million for the three- and six-month periods ended June 30, 2017, respectively, as a result of applying the new guidance. As such, we have recast the financial statements for the three- and six-month periods ended June 30, 2017 to reflect the adoption of ASU 2017-12 as follows: Three-Month Period Ended Six-Month Period Ended June 30, 2017 June 30, 2017 As Reported As Revised As Reported As Revised Net product sales $ 3,256 $ 3,259 $ 6,206 $ 6,211 Other (expense) income, net (76 ) (31 ) (50 ) (18 ) Income tax provision 69 77 153 159 Net income 1,061 1,101 2,002 2,033 Diluted net income per common share $ 1.31 $ 1.36 $ 2.47 $ 2.51 Our significant accounting policies are described in Note 1 of Notes to Consolidated Financial Statements included in our 2017 Annual Report on Form 10-K. Such significant accounting policies are applicable for periods prior to the adoption of the following new accounting standards. New accounting standards which have been adopted In May 2014, the FASB issued Accounting Standards Update No. 2014-09, “Revenue from Contracts with Customers” (ASU 2014-09) and has subsequently issued a number of amendments to ASU 2014-09. The new standard, as amended, provides a single comprehensive model to be used in the accounting for revenue arising from contracts with customers and supersedes previous revenue recognition guidance, including industry-specific guidance. The standard’s stated core principle is that an entity should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. To achieve this core principle, ASU 2014-09 includes provisions within a five step model that includes identifying the contract with a customer, identifying the performance obligations in the contract, determining the transaction price, allocating the transaction price to the performance obligations, and recognizing revenue when, or as, an entity satisfies a performance obligation. In addition, the standard requires disclosure of the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers. See Note 2 for revenue recognition disclosures. The new standard was effective for us on January 1, 2018 and we elected to adopt it using a modified retrospective transition method, which required a cumulative effect adjustment to opening retained earnings as of January 1, 2018. The implementation of ASU 2014-09 using the modified retrospective transition method did not have a material quantitative impact on our consolidated financial statements as the timing of revenue recognition did not significantly change. We also elected the following practical expedients, which were available to us as a result of utilizing the modified retrospective transition method: • We applied the provisions of the standard only to contracts that were not completed as of January 1, 2018; and • We did not retrospectively restate contracts for contract modifications executed before the beginning of the earliest period presented. In accordance with the transition provisions of ASU 2014-09, we recorded a cumulative effect adjustment of $4 million to increase Retained earnings (net of a $1 million tax effect). In limited instances, the new standard permits us to recognize revenue earlier than under the previous revenue recognition guidance. Historically, we deferred certain revenue where the transaction price pursuant to the underlying customer arrangement was not fixed or determinable. Under the new standard, such customer arrangements are accounted for as variable consideration, which results in revenue being recognized earlier provided we can reliably estimate the ultimate price expected to be realized from the customer. In addition, ASU 2014-09 requires companies who elect to adopt the standard using the modified retrospective transition method to disclose within the footnotes the effects of applying the provisions of the previous standards to current year financial statements. Revenue and net income for the three- and six-month periods ended June 30, 2018, do not differ materially from amounts that would have resulted from application of the previous standards. In January 2016 and February 2018, the FASB issued ASU 2016-01 and Accounting Standards Update No. 2018-03, "Technical Corrections and Improvements to Financial Instruments—Overall: Recognition and Measurement of Financial Assets and Financial Liabilities" (ASU-2018-03), respectively. ASU 2016-01 changes accounting for equity investments, financial liabilities under the fair value option, and presentation and disclosure requirements for financial instruments. ASU 2016-01 does not apply to equity investments in consolidated subsidiaries or those accounted for under the equity method of accounting. In addition, the FASB clarified guidance related to the valuation allowance assessment when recognizing deferred tax assets resulting from unrealized losses on available-for-sale debt securities. Equity investments with readily determinable fair values will be measured at fair value with changes in fair value recognized in net income. We have elected to measure all of our equity investments without readily determinable fair values at cost adjusted for changes in observable prices minus impairment or at net asset value (NAV), as a practical expedient, if available. Changes in measurement of equity investments without readily determinable fair values will be recognized in net income. The guidance related to equity investments without readily determinable fair values, in which the practical expedient has not been elected, will be applied prospectively to equity investments that exist as of the date of adoption. For equity investments without a readily determinable fair value in which the NAV per share practical expedient is elected, ASU 2018-03 clarified that the transition should not be performed prospectively, but rather as a cumulative effect adjustment to opening retained earnings as of the beginning of the fiscal year of adoption. Equity investments without readily determinable fair values are recorded within Other non-current assets on the Consolidated Balance Sheets. We have not elected the fair value option for financial liabilities with instrument-specific credit risk. Companies must assess valuation allowances for deferred tax assets related to available-for-sale debt securities in combination with their other deferred tax assets. ASU 2016-01 was effective for us on January 1, 2018 which required a cumulative effect adjustment to opening retained earnings to be recorded for equity investments with readily determinable fair values and equity investments without readily determinable fair values in which the NAV per share practical expedient was elected. As of the adoption date, we held publicly traded equity investments with a fair value of approximately $1.8 billion in a net unrealized gain position of $875 million , and having an associated deferred tax liability of $188 million . We recorded a cumulative effect adjustment of $687 million to decrease Accumulated other comprehensive income (AOCI) with a corresponding increase to Retained earnings for the amount of unrealized gains or losses, net of tax as of the beginning of fiscal year 2018. In addition, we held an equity investment without a readily determinable fair value in which we elected the NAV per share practical expedient. As such, on January 1, 2018, we recorded an additional cumulative effect adjustment of $59 million to increase Equity investments without readily determinable fair values as the NAV was in excess of our cost basis as of the adoption date with a corresponding increase to Retained earnings of $44 million , net of the tax effect of $15 million . As a result of the implementation of ASU 2016-01, effective on January 1, 2018 unrealized gains and losses in equity investments with readily determinable fair values and equity investments without readily determinable fair values for which observable price changes for identical or similar (e.g. dividend rights, voting rights, etc.) investments occur are recorded on the Consolidated Statement of Income within Other income (expense), net. We recorded a net loss of $6 million and net gain of $953 million in Other income (expense), net for the three- and six-month periods ended June 30, 2018, respectively, as a result of adopting this standard. The implementation of ASU 2016-01 is expected to increase volatility in our net income as the volatility previously recorded in Other comprehensive income (OCI) related to changes in the fair market value of available-for-sale equity investments will now be reflected in net income effective with the adoption date. In February 2018, the FASB issued Accounting Standards Update No. 2018-02, "Income Statement-Reporting Comprehensive Income: Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income" (ASU 2018-02). The new standard is effective on January 1, 2019 with early adoption permitted. The guidance permits a reclassification from AOCI to Retained earnings for stranded tax effects resulting from U.S. tax reform legislation enacted in December 2017 (2017 Tax Act). We elected to early adopt ASU 2018-02 on January 1, 2018. We use a specific identification approach to release the income tax effects in AOCI. We have recast our previously reported Marketable securities available-for-sale on our Consolidated Balance Sheet as of December 31, 2017 to conform to the current year presentation as outlined earlier in this Note 1. As a result of adopting this standard, we recorded a cumulative effect adjustment to increase AOCI by $117 million with a corresponding decrease to Retained earnings. We recorded the impacts of adopting ASU 2018-02 prior to recording the impacts of adopting ASU 2016-01 and included state income tax related effects in the amounts reclassified to Retained earnings. In August 2016, the FASB issued Accounting Standards Update No. 2016-15, "Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments" (ASU 2016-15). ASU 2016-15 clarifies how companies present and classify certain cash receipts and cash payments in the statement of cash flows where diversity in practice exists. ASU 2016-15 was effective for us in our first quarter of fiscal 2018 and did not result in any changes to the presentation of our Consolidated Statement of Cash Flows upon adoption. In October 2016, the FASB issued Accounting Standards Update No. 2016-16, "Intra-Entity Transfers of Assets Other Than Inventory” (ASU 2016-16). ASU 2016-16 requires the income tax consequences of intra-entity transfers of assets other than inventory to be recognized as current period income tax expense or benefit and removes the requirement to defer and amortize the consolidated tax consequences of intra-entity transfers. The new standard was effective for us on January 1, 2018. As of the adoption date, we had net prepaid tax assets of $166 million related to intra-entity transfers of assets other than inventory which was recorded in Other non-current assets. Using the modified retrospective approach, we recorded a cumulative effect adjustment of $166 million to decrease Retained earnings with a corresponding decrease in prepaid tax assets as of the beginning of fiscal year 2018. In January 2017, the FASB issued Accounting Standards Update No. 2017-01, “Business Combinations” (ASU 2017-01). ASU 2017-01 provides guidance for evaluating whether transactions should be accounted for as acquisitions (or disposals) of assets or businesses. The guidance provides a screen to determine when an integrated set of assets and activities (a “set”) does not qualify to be a business. The screen requires that when substantially all of the fair value of the gross assets acquired (or disposed of) is concentrated in an identifiable asset or a group of similar identifiable assets, the set is not a business. If the screen is not met, the guidance requires a set to be considered a business to include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create outputs and removes the evaluation as to whether a market participant could replace the missing elements. The new standard was effective for us on January 1, 2018 and was adopted on a prospective basis. In the first quarter of 2018, we acquired Impact Biomedicines Inc. (Impact) and Juno Therapeutics Inc. (Juno) which were accounted for as an asset acquisition and a business combination, respectively. See Note 3 for further information on the acquisitions of Impact and Juno. We anticipate that the adoption of this standard will result in more acquisitions being accounted for as asset acquisitions. The following table presents a summary of cumulative effect adjustments to Retained earnings due to the adoption of new accounting standards on January 1, 2018 as noted above: Cumulative Effect Adjustments to Retained Earnings on January 1, 2018 Increase / (Decrease) Cumulative effect adjustment to Retained earnings due to the adoption of the following new accounting standards: ASU 2014-09 $ 4 ASU 2016-01 687 ASU 2018-03 44 ASU 2018-02 (117 ) ASU 2016-16 (166 ) Net cumulative effect adjustments to Retained earnings on January 1, 2018 due to the adoption of new accounting standards $ 452 New accounting standards which have not yet been adopted In February 2016, the FASB issued Accounting Standards Update No. 2016-02, "Leases" (ASU 2016-02). ASU 2016-02 provides accounting guidance for both lessee and lessor accounting models. Among other things, lessees will recognize a right-of-use asset and a lease liability for leases with a duration of greater than one year. For income statement purposes, ASU 2016-02 will require leases to be classified as either an operating or finance lease. Operating leases will result in straight-line expense while finance leases will result in a front-loaded expense pattern. The new standard will be effective for us on January 1, 2019 and will be adopted using a modified retrospective approach which will require application of the new guidance at the beginning of the earliest comparative period presented. We are currently evaluating the effect that the updated standard will have on our consolidated financial statements and related disclosures. We expect the implementation of this standard to have an impact on our consolidated financial statements and related disclosures as we had aggregate future minimum lease payments of approximately $235 million as of December 31, 2017 under our portfolio of non-cancelable leased office and research facilities. In addition, Juno had $106 million of aggregate future minimum lease payments as of December 31, 2017. We anticipate recognition of additional assets and corresponding liabilities related to these leases on our consolidated balance sheet. In June 2016, the FASB issued Accounting Standards Update No. 2016-13, "Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments" (ASU 2016-13). ASU 2016-13 requires that expected credit losses relating to financial assets measured on an amortized cost basis and available-for-sale debt securities be recorded through an allowance for credit losses. ASU 2016-13 limits the amount of credit losses to be recognized for available-for-sale debt securities to the amount by which carrying value exceeds fair value and also requires the reversal of previously recognized credit losses if fair value increases. The new standard will be effective for us on January 1, 2020. Early adoption will be available on January 1, 2019. We are currently evaluating the effect that the updated standard will have on our consolidated financial statements and related disclosures.

Revenue

Revenue	6 Months Ended
	Jun. 30, 2018
Revenue from Contract with Customer [Abstract]
Revenue	Revenue Subsequent to January 1, 2018 we account for revenue in accordance with ASU 2014-09, which we adopted using the modified retrospective method. See Note 1 for further discussion of the adoption, including the impact on our consolidated financial statements. The majority of our revenue is derived from product sales. Our commercial stage products include REVLIMID ® , POMALYST®/IMNOVID ® , OTEZLA ® , ABRAXANE ® , IDHIFA ® , VIDAZA ® , azacitidine for injection (generic version of VIDAZA ® ) and THALOMID ® (sold as THALOMID ® or Thalidomide Celgene ® outside of the U.S.). In addition, we recognize revenue from other product sales and royalties based on licensees’ sales of our products or products using our technologies. We do not consider royalty revenue to be a material source of our consolidated revenue. As such, the following disclosure only relates to revenue associated with net product sales. Performance Obligations A performance obligation is a promise in a contract to transfer a distinct good or service to the customer, and is the unit of account in the current revenue standard. A contract’s transaction price is allocated to each distinct performance obligation and recognized as revenue when, or as, the performance obligation is satisfied. At contract inception, we assess the goods promised in our contracts with customers and identify a performance obligation for each promise to transfer to the customer a good that is distinct. When identifying our performance obligations, we consider all goods promised in the contract regardless of whether explicitly stated in the customer contract or implied by customary business practices. Generally, our contracts with customers require us to transfer an individual distinct product, which would represent a single performance obligation. In limited situations, our contracts with customers will require us to transfer two or more distinct products, which would represent multiple performance obligations for each distinct product. For contracts with multiple performance obligations, we allocate the contract’s transaction price to each performance obligation on a relative standalone selling price basis. In determining our standalone selling prices for our products, we utilize observable prices for our goods sold separately in similar circumstances and to customers in the same geographical region or market. Our performance obligations with respect to our product sales are satisfied at a point in time, which transfer control upon delivery of product to our customers. We consider control to have transferred upon delivery because the customer has legal title to the asset, we have transferred physical possession of the asset, the customer has significant risks and rewards of ownership of the asset, and in most instances we have a present right to payment at that time. The aggregate dollar value of unfulfilled orders as of June 30, 2018 was not material. Distribution REVLIMID ® , POMALYST ® and THALOMID ® are distributed in the United States primarily through contracted pharmacies under the REVLIMID Risk Evaluation and Mitigation Strategy (REMS), POMALYST REMS ® and THALOMID REMS® programs, respectively. These are proprietary risk-management distribution programs tailored specifically to provide for the safe and appropriate distribution and use of REVLIMID ® , POMALYST ® and THALOMID ® . Internationally, REVLIMID ® , THALOMID ® /Thalidomide Celgene ® and IMNOVID ® are distributed under mandatory risk-management distribution programs tailored to meet local authorities’ specifications to provide for the product’s safe and appropriate distribution and use. These programs may vary by country and, depending upon the country and the design of the risk-management program, the product may be sold through hospitals or retail pharmacies. OTEZLA ® , ABRAXANE ® , ISTODAX ® , IDHIFA ® and VIDAZA ® are distributed through the more traditional pharmaceutical industry supply chain and are not subject to the same risk-management distribution programs as REVLIMID ® , POMALYST ® /IMNOVID ® and THALOMID ® /Thalidomide Celgene ® . Significant Payment Terms Our contracts with our customers state the terms of the sale including the description, quantity, and price for each product purchased as well as the payment and shipping terms. Our contractual payment terms vary by jurisdiction. In the United States, our contractual payment terms are typically due in no more than 30 days. Sales made outside the United States typically have payment terms that are greater than 60 days, thereby extending collection periods beyond those in the United States. The period between when we transfer control of the promised goods to a customer and when we receive payment from such customer is expected to be one year or less. Any exceptions to this are either not material or we collect interest from the customer for the time period between the invoice due date and the payment date. As such, we do not adjust the invoice amount for the effects of a significant financing component as the impact is not material to our consolidated financial statements. Contract Balances When the timing of our delivery of product is different from the timing of payments made by the customers, we recognize either a contract asset (performance precedes the contractual due date) or a contract liability (customer payment precedes performance). There were no significant changes in our contract asset or liability balances during the three- or six-month periods ended June 30, 2018 other than from transactions in the ordinary course of operating activities as described above. Contract Assets In limited situations, certain customer contractual payment terms require us to bill in arrears; thus, we satisfy some or all of our performance obligations before we are contractually entitled to bill the customer. In these situations, billing occurs subsequent to revenue recognition, which results in a contract asset. We reflect these contract assets as Other current assets on the Consolidated Balance Sheet. For example, certain of our contractual arrangements do not permit us to bill until the product is sold through to the end-customer. As of June 30, 2018 , such contract assets were $25 million . For the three- and six-month periods ended June 30, 2018 , we recognized revenue included in such contract assets of $5 million and $28 million , respectively. Contract Liabilities In other limited situations, certain customer contractual payment terms allow us to bill in advance; thus, we receive customer cash payment before satisfying some or all of its performance obligations. In these situations, billing occurs in advance of revenue recognition, which results in contract liabilities. We reflect these contract liabilities as Deferred revenue on our Consolidated Balance Sheet. For example, certain of our contractual arrangements provide the customer with free product after the customer has purchased a contractual minimum amount of product. We concluded the free product represents a future performance obligation in the form of a contractual material right. As such, we defer a portion of the transaction price as a contract liability upon each sale of product until the contractual minimum volume is achieved. As we satisfy our remaining performance obligations we release a portion of the deferred revenue balance. Revenue recognized for the three- and six-month periods ended June 30, 2018 that was reflected in the deferred revenue balance at the beginning of the year was $82 million and $98 million , respectively. As of June 30, 2018 , such contract liabilities were $127 million . Gross to Net Sales Adjustments We record gross to net sales accruals for government rebates, chargebacks, distributor service fees, other rebates and administrative fees, sales returns and allowances, and sales discounts. Provisions for discounts, early payments, rebates, sales returns, distributor service fees and chargebacks under terms customary in the industry are provided for in the same period the related sales are recorded. We record estimated reductions to revenue for volume-based discounts and rebates at the time of the initial sale based upon the sales terms, historical experience and trend analysis. We estimate these accruals using an expected value approach based primarily upon our historical rebate and discount payments made and the provisions included in current customer contracts and government regulations. Government Rebates, including Medicaid and Medicare Rebates Government rebate accruals are based on estimated payments due to governmental agencies for purchases made by third parties under various governmental programs. In the U.S., we participate in state government Medicaid programs and other Federal and state government programs, which require rebates to participating government entities. U.S. Medicaid rebate accruals are generally based on historical payment data and estimates of future Medicaid beneficiary utilization applied to the Medicaid unit rebate formula established by the Center for Medicaid and Medicare Services. The Medicaid rebate percentage was increased and extended to Medicaid Managed Care Organizations in March 2010. The accrual of the rebates associated with Medicaid Managed Care Organizations is calculated based on estimated historical patient data related to Medicaid Managed Care Organizations. We also analyze actual billings received from the states to further support the accrual rates. Manufacturers of pharmaceutical products are responsible for 50% of the patient’s cost of branded prescription drugs related to the Medicare Part D Coverage Gap. In order to estimate the cost to us of this coverage gap responsibility, we analyze data for eligible Medicare Part D patients against data for eligible Medicare Part D patients treated with our products as well as the historical invoices. This expense is recognized throughout the year as costs are incurred. In certain international markets government-sponsored programs require rebates to be paid based on program specific rules and, accordingly, the rebate accruals are determined primarily on estimated eligible sales. Chargebacks, Distributor Service Fees, Other Rebates and Administrative Fees Chargeback accruals are based on the differentials between product acquisition prices paid by wholesalers and lower government contract pricing paid by eligible customers covered under federally qualified programs. Distributor service fee accruals are based on contractual fees to be paid to the wholesale distributor for services provided. TRICARE is a health care program of the U.S. Department of Defense Military Health System that provides civilian health benefits for military personnel, military retirees and their dependents. TRICARE rebate accruals are included in chargeback accruals and are based on estimated Department of Defense eligible sales multiplied by the TRICARE rebate formula. Rebates or administrative fees are offered to certain wholesale customers, group purchasing organizations and end-user customers, consistent with pharmaceutical industry practices. Settlement of rebates and administrative fees may generally occur from one to 15 months from the date of sale. We record a provision for rebates at the time of sale based on contracted rates and historical redemption rates. Assumptions used to establish the provision include level of wholesaler inventories, contract sales volumes and average contract pricing. We regularly review the information related to these estimates and adjust the provision accordingly. Returns, Refunds and Warranties We base our sales returns allowance on estimated on-hand retail/hospital inventories, measured end-customer demand as reported by third-party sources, actual returns history and other factors, such as the trend experience for lots where product is still being returned or inventory centralization and rationalization initiatives conducted by major pharmacy chains, as applicable. If the historical data we use to calculate these estimates do not properly reflect future returns, then a change in the allowance would be made in the period in which such a determination is made and revenues in that period could be materially affected. Under this methodology, we track actual returns by individual production lots. Returns on closed lots, that is, lots no longer eligible for return credits, are analyzed to determine historical returns experience. Returns on open lots, that is, lots still eligible for return credits, are monitored and compared with historical return trend rates. Any changes from the historical trend rates are considered in determining the current sales return allowance. We do not provide warranties on our products to our customers unless the product is defective as manufactured or damaged in transit within a reasonable period of time after receipt of the product by the customer. Sales Discounts Sales discounts are based on payment terms extended to customers, which are generally offered as an incentive for prompt payment. We record our best estimate of sales discounts to which customers are likely to be entitled based on both historical information and current trends. The reconciliation of gross product sales to net product sales by each significant category of gross-to-net adjustments was as follows: Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Gross Product Sales $ 4,530 $ 3,808 $ 8,777 $ 7,243 Gross-to-Net Adjustments: Government Rebates (269 ) (216 ) (560 ) (434 ) Chargebacks and Distributor Services Fees (390 ) (282 ) (757 ) (508 ) Sales Discounts (59 ) (48 ) (115 ) (90 ) Sales Returns and Allowances (4 ) (3 ) (6 ) — Total Gross-to-Net Adjustments (722 ) (549 ) (1,438 ) (1,032 ) Net Product Sales $ 3,808 $ 3,259 $ 7,339 $ 6,211 Total revenues from external customers by our franchises (Hematology / Oncology and Inflammation & Immunology), product and geography for the three- and six-month periods ended June 30, 2018 and June 30, 2017 were as follows: Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Hematology / Oncology: REVLIMID ® U.S. $ 1,586 $ 1,358 $ 3,073 $ 2,592 International 867 676 1,614 1,326 Worldwide 2,453 2,034 4,687 3,918 POMALYST ® /IMNOVID ® U.S. 341 241 641 457 International 166 150 319 298 Worldwide 507 391 960 755 ABRAXANE ® U.S. 152 161 311 303 International 91 93 194 187 Worldwide 243 254 505 490 VIDAZA ® U.S. 3 2 5 4 International 159 154 314 310 Worldwide 162 156 319 314 All Other U.S. 52 47 107 95 International 16 19 33 39 Worldwide 68 66 140 134 Total Hematology / Oncology: U.S. 2,134 1,809 4,137 3,451 International 1,299 1,092 2,474 2,160 Worldwide $ 3,433 $ 2,901 $ 6,611 $ 5,611 Inflammation & Immunology: OTEZLA ® U.S. $ 291 $ 306 $ 567 $ 505 International 84 52 161 95 Worldwide $ 375 $ 358 $ 728 $ 600 Total net product sales U.S. $ 2,425 $ 2,115 $ 4,704 $ 3,956 International 1,383 1,144 2,635 2,255 Worldwide $ 3,808 $ 3,259 $ 7,339 $ 6,211 Other revenue 6 12 13 22 Total revenue $ 3,814 $ 3,271 $ 7,352 $ 6,233

Acquisitions

Acquisitions	6 Months Ended
	Jun. 30, 2018
Business Combinations [Abstract]
Acquisitions	Acquisitions Acquisitions in Fiscal 2018: Impact Biomedicines, Inc. (Impact): On February 12, 2018, we acquired all of the outstanding shares of Impact, a privately held biotechnology company which was developing fedratinib, a highly selective JAK2 kinase inhibitor, for myelofibrosis. The consideration included an initial payment of approximately $1.1 billion . In addition, the sellers of Impact are eligible to receive contingent consideration based upon regulatory approvals of up to $1.4 billion and contingent consideration of up to $4.5 billion based upon the achievement of sales in any four consecutive calendar quarters between $1.0 billion and $5.0 billion . The acquisition of Impact was concentrated in one single identifiable asset and thus, for accounting purposes, we have concluded that the acquired assets do not meet the accounting definition of a business. The initial payment was allocated primarily to fedratinib, resulting in a $1.1 billion research and development asset acquisition expense and the balance of approximately $7 million was allocated to the remaining net assets acquired. Juno Therapeutics, Inc. (Juno): On March 6, 2018 (Acquisition Date), we acquired all of the outstanding shares of Juno, resulting in Juno becoming our wholly-owned subsidiary. Juno is developing CAR (chimeric antigen receptor) T and TCR (T cell receptor) therapeutics with a broad, novel portfolio evaluating multiple targets and cancer indications. The acquisition added a novel scientific platform and scalable manufacturing capabilities including JCAR017 and JCARH125, both directed CAR T therapeutics currently in programs for relapsed and/or refractory diffuse large B-cell lymphoma and relapsed/refractory multiple myeloma, respectively. Total consideration for the acquisition was approximately $10.4 billion , consisting of $9.1 billion for common stock outstanding, $966 million for the fair value of our investment in Juno and $367 million for the portion of equity compensation attributable to the pre-combination service period. In addition, the fair value of the awards attributed to post-combination service period was $666 million , which will be recognized as compensation expense over the requisite service period in the post-combination financial statements of Celgene. We recognized $150 million and $400 million of post combination share-based compensation for the three- and six-month periods ended June 30, 2018, respectively. The acquisition has been accounted for as a business combination using the acquisition method of accounting which requires that assets acquired and liabilities assumed be recognized at their fair values as of the acquisition date and requires the fair value of acquired in-process research and development (IPR&D) to be classified as indefinite-lived assets until the successful completion or abandonment of the associated research and development efforts. A preliminary purchase price allocation has been performed and the recorded amounts for intangible assets, goodwill and current and deferred tax assets and liabilities are subject to change pending finalization of valuation efforts and review of tax matters. During the second quarter of 2018, the Company recorded certain measurement period adjustments that were not material. The amounts recognized will be finalized as the information necessary to complete the analysis is obtained, but no later than one year after the acquisition date. The total consideration for the acquisition of Juno was $10.4 billion , which consisted of the following: Total Consideration Cash paid for outstanding common stock at $87.00 per share $ 9,101 Celgene investment in Juno at $87.00 per share (1) 966 Cash for equity compensation attributable to pre-combination service (2) 367 Total consideration $ 10,434 (1) The Company recognized a gain of $458 million as a result of remeasuring to fair value the equity interest in Juno held by us before the business combination, which was recorded in Other income (expense), net within the Consolidated Statement of Income during the first quarter of 2018. See Note 1 for further information on the adoption of ASU 2016-01. (2) All equity compensation attributable to pre-combination service was paid during the first quarter of 2018. The preliminary purchase price allocation resulted in the following amounts being allocated to the assets acquired and liabilities assumed at the Acquisition Date based upon their respective preliminary fair values summarized below: Amounts Recognized as of the Acquisition Date (Provisional) Working capital (1) $ 437 In-process research and development (IPR&D) 6,980 Technology platform intangible asset 1,260 Property, plant and equipment, net 144 Other non-current assets 46 Deferred tax liabilities, net (1,530 ) Other non-current liabilities (41 ) Total identifiable net assets 7,296 Goodwill 3,138 Total net assets acquired $ 10,434 (1) Includes cash and cash equivalents, debt securities available-for-sale, accounts receivable, other current assets, accounts payable, accrued expenses and other current liabilities (including accrued litigation). See Note 16 for litigation matters related to Juno. The fair value assigned to acquired IPR&D was based on the present value of expected after-tax cash flows attributable to JCAR017, which is in a pivotal phase II trial and JCARH125. The present value of expected after-tax cash flows attributable to JCAR017 and JCARH125 assigned to IPR&D was determined by estimating the after-tax costs to complete development of JCAR017 and JCARH125 into commercially viable products, estimating future revenue and ongoing expenses to produce, support and sell JCAR017 and JCARH125, on an after-tax basis, and discounting the resulting net cash flows to present value. The revenue and costs projections used were reduced based on the probability that products at similar stages of development will become commercially viable products. The rate utilized to discount the net cash flows to their present value reflects the risk associated with the intangible asset and is benchmarked to the cost of equity. Acquired IPR&D will be accounted for as indefinite-lived intangible assets until regulatory approvals for JCAR017 and JCARH125 in a major market or discontinuation of development. The excess of purchase price over the fair value amounts assigned to identifiable assets acquired and liabilities assumed represents the goodwill amount resulting from the acquisition. The goodwill recorded as part of the acquisition is primarily attributable to the broadening of our product portfolio and research capabilities in the hematology and oncology therapeutic area, the assembled workforce and the deferred tax consequences of the IPR&D asset recorded for financial statement purposes. We do not expect any portion of this goodwill to be deductible for tax purposes. The goodwill attributable to the acquisition has been recorded as a non-current asset in our Consolidated Balance Sheets and is not amortized, but is subject to review for impairment annually. Juno actual results for the three-months ended June 30, 2018 and from the Acquisition Date through June 30, 2018, which are included in the Consolidated Statement of Income are as follows: Classification in the Consolidated Statements of Income Three-Months Ended June 30, 2018 Acquisition Date Through June 30, 2018 Other revenue $ 1 $ 1 Research and development (1) 225 385 Selling, general and administrative (1) 79 210 Amortization of acquired intangible assets 21 28 Acquisition related charges (income) and restructuring, net (2) 27 49 Interest and investment income, net 3 3 Other income (expense), net 15 11 Income tax provision (benefit), net (63 ) (83 ) Total $ (270 ) $ (574 ) (1) Includes share-based compensation expense related to the post-combination service period of $100 million and $50 million , which was recorded in Research and development and Selling, general and administrative expenses, respectively, for the three-months ended June 30, 2018. Also includes share-based compensation expense related to the post-combination service period of $233 million and $167 million , which was recorded in Research and development and Selling, general and administrative expenses, respectively, for the period from the acquisition date through June 30, 2018. (2) Consists of acquisition related compensation expense, transaction costs and the change in fair value of contingent consideration and success payment liabilities. In addition, Celgene incurred incremental acquisition costs related to Juno of nil and $41 million for the three- and six-month periods ended June 30, 2018 respectively. Pro Forma Financial Information: The following table provides unaudited pro forma financial information for the six-month period ended June 30, 2018 and the three- and six-month periods ended June 30, 2017 as if the acquisition of Juno had occurred on January 1, 2017. Six-Month Periods Ended June 30, Three-Month Period Ended June 30, 2017 2018 2017 Total revenue $ 7,362 $ 6,234 $ 3,272 Net income 1,805 1,495 994 Net income per common share: basic $ 2.47 $ 1.92 $ 1.27 Net income per common share: diluted $ 2.40 $ 1.84 $ 1.22 The unaudited pro forma financial information was prepared using the acquisition method of accounting and was based on the historical financial information of Celgene and Juno. The supplemental pro forma financial information reflects primarily the following pro forma adjustments: • Elimination of research related cost sharing transactions between Celgene and Juno; • The pro forma financial information assumes that the acquisition related transaction fees and costs, including post combination share-based compensation related to the acquisition, were removed from the three- and six-month periods ended June 30, 2018 and were assumed to have been incurred during the first quarter of 2017; • The pro forma financial information assumes that the gain recognized as a result of remeasuring to fair value the equity interest we held in Juno prior to the business combination was removed from the six-month period ended June 30, 2018 and was assumed to have been recognized during the first quarter of 2017; • Additional interest expense and amortization of debt issuance costs for a portion of the $4.5 billion of debt that was issued in February 2018 to partially finance the acquisition; • Additional amortization expense on the acquired technology platform asset; and • Statutory tax rates were applied, as appropriate, to each pro forma adjustment based on the jurisdiction in which the adjustment occurred. The unaudited pro forma results do not reflect any operating efficiencies or potential cost savings that may result from the combined operations of Celgene and Juno. Accordingly, these unaudited pro forma results are presented for illustrative purposes and are not intended to represent or be indicative of the actual results of operations of the combined company that would have been achieved had the acquisition occurred at the beginning of the period presented, nor are they intended to represent or be indicative of future results of operations. Acquisitions in Fiscal 2017: Delinia, Inc. (Delinia): On February 3, 2017, we acquired all of the outstanding shares of Delinia, a privately held biotechnology company focused on developing novel therapeutics for the treatment of autoimmune diseases. The transaction expands our Inflammation and Immunology pipeline primarily through the acquisition of Delinia’s lead program, DEL-106, as well as related second generation programs. DEL-106 is a novel IL-2 mutein Fc fusion protein designed to preferentially upregulate regulatory T cells (Tregs), immune cells that are critical to maintaining natural self-tolerance and immune system homeostasis. The consideration included an initial payment of $302 million . In addition, the sellers of Delinia are eligible to receive up to $475 million in contingent development, regulatory and commercial milestones. The acquisition did not include any significant processes and thus, for accounting purposes, we have concluded that the acquired assets did not meet the definition of a business. The initial payment was allocated primarily to the DEL-106 program, resulting in a $300 million research and development asset acquisition expense and approximately $2 million of net assets acquired. Other acquisitions: In addition, during the first quarter of 2017, we acquired all of the outstanding shares of a privately held biotechnology company for total initial consideration of $26 million . The sellers are also eligible to receive up to $210 million in contingent development and regulatory approval milestones. The acquisition did not include any significant processes and thus, for accounting purposes, we have concluded that the acquired assets did not meet the definition of a business. The consideration transferred resulted in a $25 million research and development asset acquisition expense and $1 million of net assets acquired.

Earnings Per Share

Earnings Per Share	6 Months Ended
	Jun. 30, 2018
Earnings Per Share [Abstract]
Earnings Per Share	Earnings Per Share Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, (Amounts in millions, except per share) 2018 2017 2018 2017 Net income $ 1,045 $ 1,101 $ 1,891 $ 2,033 Weighted-average shares: Basic 716.1 780.4 732.1 779.7 Effect of dilutive securities: Options, restricted stock units, performance-based restricted stock units and other 16.5 31.3 18.5 31.8 Diluted 732.6 811.7 750.6 811.5 Net income per share: Basic $ 1.46 $ 1.41 $ 2.58 $ 2.61 Diluted $ 1.43 $ 1.36 $ 2.52 $ 2.51 The total number of potential shares of common stock excluded from the diluted earnings per share computation because their inclusion would have been anti-dilutive was 45.6 million and 21.4 million shares for the three-month periods ended June 30, 2018 and 2017 , respectively, and 41.3 million and 22.0 million shares for the six-month periods ended June 30, 2018 and 2017 , respectively. Share Repurchase Program: In February and May 2018, our Board of Directors approved increases of $5.0 billion and $3.0 billion , respectively to our authorized share repurchase program, bringing the total amount authorized since April 2009 to $28.5 billion of our common stock. As part of the existing Board authorized share repurchase program, in May 2018, we entered into an Accelerated Share Repurchase (ASR) agreement with a bank to repurchase an aggregate of $2.0 billion of our common stock. As part of the ASR agreement, we received an initial delivery of approximately 18.0 million shares, which is included in Common stock in treasury in the accompanying Consolidated Balance Sheet as of June 30, 2018, at a cost of approximately $1.4 billion . The initial delivery reduced our outstanding shares used to determine our weighted average shares outstanding for purposes of calculating basic and diluted earnings per share. The remaining $600 million was included in Additional paid-in capital in the accompanying Consolidated Balance Sheet as of June 30, 2018. The total number of shares that will ultimately be repurchased under the ASR agreement will be determined upon final settlement, which we anticipate will be in the third quarter of 2018 and will be based on a discount to the volume-weighted average price of our common stock during the ASR period. We have evaluated the ASR agreement for its potential dilution of earnings per share and determined that the additional shares to be received upon final settlement would have had an anti-dilutive effect and as a result, these shares were not included in our weighted average diluted earnings per share calculation. As part of the management of our share repurchase program, we may, from time to time, sell put options on our common stock with strike prices that we believe represent an attractive price to purchase our shares. If the trading price of our shares exceeds the strike price of the put option at the time the option expires, we will have economically reduced the cost of our share repurchase program by the amount of the premium we received from the sale of the put option. If the trading price of our stock is below the strike price of the put option at the time the option expires, we would purchase the shares covered by the option at the strike price of the put option. During the three- and six-month periods ended June 30, 2018 and 2017, there were no gains or losses from the sale of put options. As of June 30, 2018 and December 31, 2017, we had no outstanding put options. We have purchased 32.8 million and 61.8 million shares of common stock under the share repurchase program from all sources at a total cost of $2.7 billion and $5.4 billion during the three- and six-month periods ended June 30, 2018 , respectively. As of June 30, 2018 , we had a remaining share repurchase authorization of $2.8 billion .

Accumulated Other Comprehensive

Accumulated Other Comprehensive Income (Loss)	6 Months Ended
	Jun. 30, 2018
Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]
Accumulated Other Comprehensive Income (Loss)	Accumulated Other Comprehensive Income (Loss) During the third quarter of 2017, we adopted ASU 2017-12 on a modified retrospective basis. As a result of applying the new guidance during the nine-month period ended September 30, 2017, we recorded a cumulative effect adjustment of $30 million to decrease AOCI as of the beginning of fiscal year 2017 and adjustments to pre-tax income of $48 million and $37 million , respectively for the three- and six-month periods ended June 30, 2017 with corresponding decreases to AOCI. As such, certain disclosures for the three- and six-month periods ended June 30, 2017 below have been recast to conform to the disclosure requirements related to the adoption of ASU 2017-12. See Note 1 for additional information related to the adoption of ASU 2017-12. The components of other comprehensive income (loss) consist of changes in pension liability, changes in net unrealized gains (losses) on debt securities available-for-sale and equity investments with readily determinable fair values in 2017 and debt securities available-for-sale in 2018, net unrealized gains (losses) related to cash flow hedges, the amortization of the excluded component related to cash flow hedges and changes in foreign currency translation adjustments. The accumulated balances related to each component of other comprehensive income (loss), net of tax, are summarized as follows: Pension Liability Adjustment Net Unrealized Gains (Losses) On Available-for-Sale Debt Securities / Marketable Securities (1) Net Unrealized Gains (Losses) Related to Cash Flow Hedges Amortization of Excluded Component Related to Cash Flow Hedges (See Note 1) Foreign Currency Translation Adjustments Accumulated Other Comprehensive Income (Loss) Balance as of December 31, 2017 $ (22 ) $ 562 $ (206 ) $ (15 ) $ (32 ) $ 287 Cumulative effect adjustment for the adoption of ASU 2016-01 and ASU 2018-02 (See Note 1) — (566 ) (4 ) — — (570 ) Other comprehensive (loss) income before reclassifications, net of tax — (7 ) 128 (15 ) (12 ) 94 Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax — 14 39 17 — 70 Net current-period other comprehensive income (loss), net of tax — 7 167 2 (12 ) 164 Balance as of June 30, 2018 $ (22 ) $ 3 $ (43 ) $ (13 ) $ (44 ) $ (119 ) Balance as of December 31, 2016 $ (38 ) $ 144 $ 415 $ — $ (102 ) $ 419 Cumulative effect adjustment for the adoption of ASU 2017-12 — — (12 ) (18 ) — (30 ) Other comprehensive income (loss) before reclassifications, net of tax — 148 (259 ) (5 ) 41 (75 ) Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax — 21 (165 ) — — (144 ) Net current-period other comprehensive income (loss), net of tax — 169 (424 ) (5 ) 41 (219 ) Balance as of June 30, 2017 $ (38 ) $ 313 $ (21 ) $ (23 ) $ (61 ) $ 170 (1) Balances as of December 31, 2017 are prior to the adoption of ASU 2016-01 and, as such, include equity securities with readily determinable fair values. Upon adoption of ASU 2016-01, we recorded a cumulative effect adjustment for our net unrealized gains related to our equity securities with readily determinable fair values as of January 1, 2018. Therefore, the unrealized gains (losses) position as of June 30, 2018 solely relate to debt securities available-for-sale. See Note 1 for further information related to the adoption of ASU 2016-01. Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income Accumulated Other Comprehensive Income (Loss) Components Classification in the Consolidated Statements of Income Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 (Losses) gains related to cash-flow hedges: Foreign exchange contracts Net product sales $ (12 ) $ 81 $ (38 ) $ 167 Treasury rate lock agreements Interest (expense) (1 ) (2 ) (2 ) (3 ) Interest rate swap agreements Interest (expense) — — — (1 ) Income tax provision - (expense) benefit 1 1 1 2 Excluded component related to cash-flow hedges: Foreign exchange contracts Net product sales 1 3 (2 ) 5 (Losses) gains on available-for-sale debt securities / marketable securities (1) : Realized (loss) gain on sales of debt securities / marketable securities Interest and investment income, net — (34 ) (18 ) (34 ) Income tax provision - (expense) benefit — 13 4 13 Total reclassification, net of tax $ (11 ) $ 62 $ (55 ) $ 149 (1) (Losses) gains reclassified out of Accumulated other comprehensive income prior to December 31, 2017 are prior to the adoption of ASU 2016-01 and, as such, include equity securities with readily determinable fair values. Upon adoption of ASU 2016-01, we recorded a cumulative effect adjustment for our net unrealized gains related to our equity securities with readily determinable fair values as of January 1, 2018. Therefore, unrealized gains (losses) for the three- and six-month periods ended June 30, 2018 solely relate to debt securities available-for-sale. See Note 1 for further information related to the adoption of ASU 2016-01.

Financial Instruments and Fair

Financial Instruments and Fair Value Measurement	6 Months Ended
	Jun. 30, 2018
Fair Value Disclosures [Abstract]
Financial Instruments and Fair Value Measurement	Financial Instruments and Fair Value Measurement The tables below present information about assets and liabilities that are measured at fair value on a recurring basis as of June 30, 2018 and December 31, 2017 and the valuation techniques we utilized to determine such fair value. • Level 1 inputs utilize quoted prices (unadjusted) in active markets for identical assets or liabilities. Our level 1 assets consist of debt securities available-for-sale and equity investments with readily determinable fair values. Our level 1 liability relates to our publicly traded contingent value rights (CVRs). See Note 18 of Notes to Consolidated Financial Statements included in our 2017 Annual Report on Form 10-K for a description of the CVRs. • Level 2 inputs utilize observable quoted prices for similar assets and liabilities in active markets and observable quoted prices for identical or similar assets in markets that are not very active. From time to time, our level 2 assets consist of U.S. Treasury securities, U.S. government-sponsored agency securities, U.S. government-sponsored agency mortgage-backed securities (MBS), global corporate debt securities, asset backed securities, ultra short income fund investments, time deposits and repurchase agreements with original maturities of greater than three months, foreign currency forward contracts, purchased foreign currency options and interest rate swap contracts. Our level 2 liabilities relate to written foreign currency options, foreign currency forward contracts and interest rate swap contracts. • Level 3 inputs utilize unobservable inputs and include valuations of assets or liabilities for which there is little, if any, market activity. We do not have any level 3 assets. Our level 3 liabilities consist of contingent consideration related to undeveloped product rights and technology platforms resulting from the acquisitions of Gloucester Pharmaceuticals, Inc. (Gloucester), Nogra Pharma Limited (Nogra), Avila Therapeutics, Inc. (Avila) and Quanticel Pharmaceuticals, Inc. (Quanticel). In addition, in connection with our acquisition of Juno in the first quarter of 2018, we assumed Juno's contingent consideration and success payment liabilities. Our contingent consideration obligations are recorded at their estimated fair values and we revalue these obligations each reporting period until the related contingencies are resolved. The fair value measurements are estimated using probability-weighted discounted cash flow approaches that are based on significant unobservable inputs related to product candidates acquired in business combinations and are reviewed quarterly. These inputs include, as applicable, estimated probabilities and timing of achieving specified development and regulatory milestones, estimated annual sales and the discount rate used to calculate the present value of estimated future payments. Significant changes which increase or decrease the probabilities of achieving the related development and regulatory events, shorten or lengthen the time required to achieve such events, or increase or decrease estimated annual sales would result in corresponding increases or decreases in the fair values of these obligations. The fair value of our contingent consideration as of June 30, 2018 and December 31, 2017 was calculated using the following significant unobservable inputs: Inputs Ranges (weighted average) utilized as of: June 30, 2018 December 31, 2017 Discount rate 2.5% to 4.0% (3.2%) 2.7% to 12.0% (3.5%) Probability of payment 0% to 68% (4.6%) 0% to 20% (4%) Projected year of payment for development and regulatory milestones 2020 to 2029 (2023) 2020 to 2029 (2024) Projected year of payment for sales-based milestones and other amounts calculated as a percentage of annual sales N/A 2024 to 2030 (2028) The maximum remaining potential payments related to the contingent consideration from the acquisitions of Gloucester, Avila, Quanticel and those assumed in our acquisition of Juno are estimated to be approximately $120 million , $475 million , $214 million and $296 million , respectively, and $1.8 billion plus other amounts calculated as a percentage of annual sales pursuant to the license agreement with Nogra. Success payment obligations assumed through our acquisition of Juno are also recorded at their estimated fair values and are revalued quarterly. Changes in the fair value of contingent consideration and success payment obligations are recognized in Acquisition related charges (income) and restructuring, net in the Consolidated Statements of Income. Effective January 1, 2018, we adopted ASU 2016-01. Among other provisions, the new standard required modifications to existing presentation and disclosure requirements on a prospective basis. Certain disclosures as of December 31, 2017 below conform to the disclosure requirements of ASU 2016-01. See Note 1 for additional information related to the adoption of ASU 2016-01. The following tables present the Company's hierarchy for its assets and liabilities measured at fair value on a recurring basis as of June 30, 2018 and December 31, 2017 : Fair Value Measurements as of June 30, 2018 Balance as of June 30, 2018 Quoted Price in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Assets: Debt securities available-for-sale $ 79 $ — $ 79 $ — Equity investments with readily determinable fair values 1,828 1,828 — — Forward currency contracts 27 — 27 — Purchased currency options 33 — 33 — Total assets $ 1,967 $ 1,828 $ 139 $ — Liabilities: Contingent value rights $ (18 ) $ (18 ) $ — $ — Interest rate swaps (27 ) — (27 ) — Written currency options (81 ) — (81 ) — Other acquisition related contingent consideration and success payments (193 ) — — (193 ) Total liabilities $ (319 ) $ (18 ) $ (108 ) $ (193 ) Fair Value Measurements as of December 31, 2017 Balance as of December 31, 2017 Quoted Price in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Assets: Debt securities available-for-sale $ 3,219 $ — $ 3,219 $ — Equity investments with readily determinable fair values 1,810 1,810 — — Purchased currency options 36 — 36 — Total assets $ 5,065 $ 1,810 $ 3,255 $ — Liabilities: Contingent value rights $ (42 ) $ (42 ) $ — $ — Forward currency contracts (42 ) — (42 ) — Interest rate swaps (7 ) — (7 ) — Written currency options (172 ) — (172 ) — Other acquisition related contingent consideration (80 ) — — (80 ) Total liabilities $ (343 ) $ (42 ) $ (221 ) $ (80 ) As of result of the implementation of ASU 2016-01 and ASU 2018-03, effective on January 1, 2018, we measure equity investments without a readily determinable fair value at cost, less any impairment, plus or minus changes resulting from observable price changes in orderly transactions for an identical or similar investment of the same issuer or at NAV, as a practical expedient, if available. We record upward adjustments, downward adjustments and impairments of equity investments without readily determinable fair values within Other income (expense), net on the Consolidated Statement of Income. The following table represents a roll-forward of equity investments without readily determinable fair values: Six-Month Period Ended June 30, 2018 Balance as of December 31, 2017 $ 513 Cumulative effect adjustment for the adoption of ASU 2018-03 (See Note 1) 59 Purchases 46 Upward adjustments 32 Sales (23 ) Downward adjustments (1 ) Impairments (1 ) Transfer to readily determinable fair value (20 ) Balance as of June 30, 2018 $ 605 For equity investments with and without readily determinable fair values held as of June 30, 2018 , we recorded a net unrealized loss of $11 million and a net unrealized gain of $435 million within Other income (expense), net on the Consolidated Statement of Income for the three- and six-month periods ended June 30, 2018 , respectively. There were no security transfers between levels 1, 2 and 3 during the three-month periods ended June 30, 2018 and 2017 . The following table represents a roll-forward of the fair value of level 3 instruments: Three-Month Period Ended June 30, 2018 Liabilities: Balance as of March 31, 2018 $ (201 ) Amounts acquired from Juno, including measurement period adjustments 6 Settlements, including transfers to Accrued expenses and other current liabilities 2 Balance as of June 30, 2018 $ (193 ) Three-Month Period Ended June 30, 2017 Liabilities: Balance as of March 31, 2017 $ (1,527 ) Net change in fair value 20 Settlements, including transfers to Accrued expenses and other current liabilities 19 Balance as of June 30, 2017 $ (1,488 ) There were no security transfers between levels 1, 2 and 3 during the six-month periods ended June 30, 2018 and 2017 . The following table represents a roll-forward of the fair value of level 3 instruments: Six-Month Period Ended June 30, 2018 Liabilities: Balance as of December 31, 2017 $ (80 ) Amounts acquired from Juno, including measurement period adjustments (116 ) Net change in fair value 1 Settlements, including transfers to Accrued expenses and other current liabilities 2 Balance as of June 30, 2018 $ (193 ) Six-Month Period Ended June 30, 2017 Liabilities: Balance as of December 31, 2016 $ (1,490 ) Net change in fair value (17 ) Settlements, including transfers to Accrued expenses and other current liabilities 19 Balance as of June 30, 2017 $ (1,488 ) As previously reported in our 2017 Annual Report on Form 10-K, we reduced our contingent consideration liabilities related to Nogra by $1,397 million due to the discontinuance of the GED-0301 phase III REVOLVE (CD-002) trial in Crohn's disease and the SUSTAIN (CD-004) extension trial in the fourth quarter of 2017.

Derivative Instruments and Hedg

Derivative Instruments and Hedging Activities	6 Months Ended
	Jun. 30, 2018
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Derivative Instruments and Hedging Activities	Derivative Instruments and Hedging Activities During the third quarter of 2017, we adopted ASU 2017-12 on a modified retrospective basis. We recorded pre-tax income of $48 million and $37 million for the three- and six-month period ended June 30, 2017 as a result of applying the new guidance during the nine-month period ended September 30, 2017. As such, certain disclosures for the three- and six-month periods ended June 30, 2017 below have been recast to conform to the disclosure requirements related to the adoption of ASU 2017-12. See Note 1 for additional information related to the adoption of ASU 2017-12. Our revenue and earnings, cash flows and fair values of assets and liabilities can be impacted by fluctuations in foreign exchange rates and interest rates. We actively manage the impact of foreign exchange rate and interest rate movements through operational means and through the use of various financial instruments, including derivative instruments such as foreign currency option contracts, foreign currency forward contracts, treasury rate lock agreements and interest rate swap contracts. In instances where these financial instruments are accounted for as cash flow hedges or fair value hedges we may from time to time terminate the hedging relationship. If a hedging relationship is terminated, we generally either settle the instrument or enter into an offsetting instrument. Foreign Currency Risk Management We maintain a foreign exchange exposure management program to mitigate the impact of volatility in foreign exchange rates on future foreign currency cash flows, translation of foreign earnings and changes in the fair value of assets and liabilities denominated in foreign currencies. Through our revenue hedging program, we endeavor to reduce the impact of possible unfavorable changes in foreign exchange rates on our future U.S. Dollar cash flows that are derived from foreign currency denominated sales. To achieve this objective, we hedge a portion of our forecasted foreign currency denominated sales that are expected to occur in the foreseeable future, typically within the next three years , with a maximum of five years . We manage our anticipated transaction exposure principally with foreign currency forward contracts, a combination of foreign currency put and call options, and occasionally purchased foreign currency put options. Foreign Currency Forward Contracts: We use foreign currency forward contracts to hedge specific forecasted transactions denominated in foreign currencies, manage exchange rate volatility in the translation of foreign earnings, and reduce exposures to foreign currency fluctuations of certain assets and liabilities denominated in foreign currencies. We manage a portfolio of foreign currency forward contracts to protect against changes in anticipated foreign currency cash flows resulting from changes in foreign currency exchange rates, primarily associated with non-functional currency denominated revenues and expenses of foreign subsidiaries. The foreign currency forward hedging contracts outstanding as of June 30, 2018 and December 31, 2017 had settlement dates within 36 months and 20 months , respectively. The spot rate components of these foreign currency forward contracts are designated as cash flow hedges and any unrealized gains or losses are reported in OCI and reclassified to the Consolidated Statement of Income in the same periods during which the underlying hedged transactions affect earnings. If a hedging relationship is terminated with respect to a foreign currency forward contract, accumulated gains or losses associated with the contract remain in OCI until the hedged forecasted transaction occurs and are reclassified to operations in the same periods during which the underlying hedged transactions affect earnings. We recognize in earnings the initial value of the forward point components on a straight-line basis over the life of the derivative instrument within the same line item in the Consolidated Statements of Income that is used to present the earnings effect of the hedged item. Foreign currency forward contracts entered into to hedge forecasted revenue and expenses were as follows as of June 30, 2018 and December 31, 2017 : Notional Amount Foreign Currency June 30, 2018 December 31, 2017 Australian Dollar $ 46 $ 61 British Pound 134 97 Canadian Dollar 190 227 Euro 962 954 Japanese Yen 508 356 Total $ 1,840 $ 1,695 We consider the impact of our own and the counterparties’ credit risk on the fair value of the contracts as well as the ability of each party to execute its obligations under the contract on an ongoing basis. As of June 30, 2018 , credit risk did not materially change the fair value of our foreign currency forward contracts. We also manage a portfolio of foreign currency contracts to reduce exposures to foreign currency fluctuations of certain recognized assets and liabilities denominated in foreign currencies and, from time to time, we enter into foreign currency contracts to manage exposure related to translation of foreign earnings. These foreign currency forward contracts have not been designated as hedges and, accordingly, any changes in their fair value are recognized on the Consolidated Statements of Income in Other income (expense), net in the current period. The aggregate notional amount of the foreign currency forward non-designated hedging contracts outstanding as of June 30, 2018 and December 31, 2017 were $748 million and $885 million , respectively. Foreign Currency Option Contracts: From time to time, we may hedge a portion of our future foreign currency exposure by utilizing a strategy that involves both a purchased local currency put option and a written local currency call option that are accounted for as hedges of future sales denominated in that local currency. Specifically, we sell (or write) a local currency call option and purchase a local currency put option with the same expiration dates and local currency notional amounts but with different strike prices. This combination of transactions is generally referred to as a “collar.” The expiration dates and notional amounts correspond to the amount and timing of forecasted foreign currency sales. The foreign currency option contracts outstanding as of June 30, 2018 and December 31, 2017 had settlement dates within 30 months and 36 months , respectively. If the U.S. Dollar weakens relative to the currency of the hedged anticipated sales, the purchased put option value reduces to zero and we benefit from the increase in the U.S. Dollar equivalent value of our anticipated foreign currency cash flows; however, this benefit would be capped at the strike level of the written call, which forms the upper end of the collar. The premium collected from the sale of the call option is equal to the premium paid for the purchased put option, resulting in a net zero cost for each collar. Outstanding foreign currency option contracts entered into to hedge forecasted revenue were as follows as of June 30, 2018 and December 31, 2017 : Notional Amount (1) June 30, 2018 December 31, 2017 Foreign currency option contracts designated as hedging activity: Purchased Put $ 2,756 $ 3,319 Written Call 3,131 3,739 (1) U.S. Dollar notional amounts are calculated as the hedged local currency amount multiplied by the strike value of the foreign currency option. The local currency notional amounts of our purchased put and written call that are designated as hedging activities are equal to each other. We also have entered into foreign currency put option contracts to hedge forecasted revenue which were not part of a collar strategy. Such put option contracts had a notional amount of $129 million and $258 million as of June 30, 2018 and December 31, 2017, respectively, and settlement dates within 6 months and 12 months , respectively. Interest Rate Risk Management Forward Starting Interest Rate Swaps and Treasury Rate Locks: In anticipation of issuing fixed-rate debt, we may use forward starting interest rate swaps (forward starting swaps) or treasury rate lock agreements (treasury rate locks) that are designated as cash flow hedges to hedge against changes in interest rates that could impact expected future issuances of debt. To the extent these hedges of cash flows related to anticipated debt are effective, any realized or unrealized gains or losses on the forward starting swaps or treasury rate locks are reported in OCI and are recognized in income over the life of the anticipated fixed-rate notes. As of June 30, 2018 and December 31, 2017 , we did not have any outstanding forward starting swaps or treasury rate locks. Interest Rate Swap Contracts: From time to time we hedge the fair value of certain debt obligations through the use of interest rate swap contracts. The interest rate swap contracts are designated hedges of the fair value changes in the notes attributable to changes in benchmark interest rates. Gains or losses resulting from changes in fair value of the underlying debt attributable to the hedged benchmark interest rate risk are recorded on the Consolidated Statement of Income within Interest (expense) with an associated offset to the carrying value of the notes recorded on the Consolidated Balance Sheet. Since the specific terms and notional amount of the swap are intended to match those of the debt being hedged all changes in fair value of the swap are recorded on the Consolidated Statement of Income within Interest (expense) with an associated offset to the derivative asset or liability on the Consolidated Balance Sheet. Consequently, there is no net impact recorded in income. Any net interest payments made or received on interest rate swap contracts are recognized as interest expense on the Consolidated Statements of Income. If a hedging relationship is terminated for an interest rate swap contract, accumulated gains or losses associated with the contract are measured and recorded as a reduction or increase of current and future interest expense associated with the previously hedged debt obligations. The following table summarizes the notional amounts of our outstanding interest rate swap contracts as of June 30, 2018 and December 31, 2017: Notional Amount June 30, 2018 December 31, 2017 Interest rate swap contracts entered into as fair value hedges of the following fixed-rate senior notes: 3.875% senior notes due 2025 $ 200 $ 200 3.450% senior notes due 2027 550 250 3.900% senior notes due 2028 200 — Total $ 950 $ 450 We have entered into swap contracts that were designated as hedges of certain of our fixed rate notes in 2018 and 2017, and also terminated the hedging relationship by settling certain of those swap contracts during 2018 and 2017. In 2018, we settled $150 million notional amount of certain swap contracts. There were no material cash proceeds as a result of settling such swap contracts. During 2017, we terminated the hedging relationship on certain outstanding swap contracts amounting to $200 million notional amount by settling such swap contracts. The settlement of swap contracts resulted in the receipt of net proceeds of $3 million during the year ended December 31, 2017, which are accounted for as a reduction of current and future interest expense associated with these notes. See Note 11 for additional details related to reductions of current and future interest expense. The following tables summarize the fair value and presentation in the Consolidated Balance Sheets for derivative instruments as of June 30, 2018 and December 31, 2017 : June 30, 2018 Balance Sheet Location Fair Value Instrument Asset Derivatives Liability Derivatives Derivatives designated as hedging instruments: Foreign exchange contracts (1) Other current assets $ 56 $ 29 Accrued expenses and other current liabilities 4 10 Other non-current assets 4 — Other non-current liabilities 34 68 Interest rate swap agreements Other current assets 7 — Other non-current liabilities — 36 Derivatives not designated as hedging instruments: Foreign exchange contracts (1) Other current assets 25 3 Accrued expenses and other current liabilities 3 37 Interest rate swap agreements Other current assets 2 1 Other non-current assets 7 6 Total $ 142 $ 190 (1) Derivative instruments in this category are subject to master netting arrangements and are presented on a net basis in the Consolidated Balance Sheet in accordance with ASC 210-20. December 31, 2017 Fair Value Instrument Balance Sheet Location Asset Derivatives Liability Derivatives Derivatives designated as hedging instruments: Foreign exchange contracts (1) Other current assets $ 5 $ 1 Accrued expenses and other current liabilities 30 79 Other non-current assets 1 — Other non-current liabilities 36 159 Interest rate swap agreements Other current assets 3 — Other non-current liabilities — 11 Derivatives not designated as hedging instruments: Foreign exchange contracts (1) Other current assets 8 1 Accrued expenses and other current liabilities 4 22 Interest rate swap agreements Other current assets 2 2 Other non-current assets 4 3 Total $ 93 $ 278 (1) Derivative instruments in this category are subject to master netting arrangements and are presented on a net basis in the Consolidated Balance Sheet in accordance with ASC 210-20. As of June 30, 2018 and December 31, 2017, the following amounts were recorded on the Consolidated Balance Sheet related to cumulative basis adjustments for fair value hedges: Carrying Amount of the Hedged Liability Cumulative Amount of Fair Value Hedging Adjustment Included in the Carrying Amount of the Hedged Liability Consolidated Balance Sheet Classification in Which the Hedged Item Is Included June 30, 2018 (1) December 31, 2017 (1) June 30, 2018 (2) December 31, 2017 (2) Current portion of long-term debt, net of discount $ 503 $ — $ 4 $ — Long-term debt, net of discount 8,173 7,270 84 128 (1) The current portion of long-term debt, net of discount includes approximately $503 million of carrying value with discontinued hedging relationships at June 30, 2018. The long-term debt, net of discount includes approximately $3.2 billion and $3.8 billion of carrying value with discontinued hedging relationships as of June 30, 2018 and December 31, 2017, respectively. (2) The current portion of long-term debt, net of discount includes $4 million of discontinued hedging relationships at June 30, 2018. The long-term debt, net of discount includes $120 million and $139 million of hedging adjustment on discontinued hedging relationships on long-term debt as of June 30, 2018 and December 31, 2017, respectively. The following tables summarize the effect of derivative instruments designated as cash flow hedging instruments in Accumulated OCI for the three-month periods ended June 30, 2018 and 2017 : Three-Month Period Ended June 30, 2018 Instrument Amount of (1), (2) Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ 226 Net product sales $ (12 ) Net product sales $ 1 Treasury rate lock agreements — Interest (expense) (1 ) N/A — (1) Net losses of $7 million are expected to be reclassified from Accumulated OCI into income in the next 12 months. (2) For the three-month period ended June 30, 2018, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a gain of $1 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. Three-Month Period Ended June 30, 2017 Instrument Amount of Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ (181 ) Net product sales $ 81 Net product sales $ 3 Other income (expense), net 1 Treasury rate lock agreements — Interest (expense) (2 ) N/A — Forward starting interest rate swaps (17 ) Interest (expense) — N/A — The following tables summarize the effect of derivative instruments designated as cash flow hedging instruments in Accumulated OCI for the six-month periods ended June 30, 2018 and 2017 : Six-Month Period Ended June 30, 2018 Instrument Amount of (1), (2) Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ 131 Net product sales $ (38 ) Net product sales $ (2 ) Treasury rate lock agreements (4 ) Interest (expense) (2 ) Other income (expense), net — (1) Net losses of $7 million are expected to be reclassified from Accumulated OCI into income in the next 12 months. (2) For the six-month period ended June 30, 2018, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a loss of $2 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. Six-Month Period Ended June 30, 2017 Instrument Amount of Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ (249 ) Net product sales $ 167 Net product sales $ 5 Other income (expense), net 8 Treasury rate lock agreements — Interest (expense) (3 ) N/A — Forward starting interest rate swaps (17 ) Interest (expense) (1 ) N/A — (1) For the six-month period ended June 30, 2017, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a gain of $5 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. The following table summarizes the effect of derivative instruments which were designated as fair value hedging instruments on the Consolidated Statements of Income for the three-month periods ended June 30, 2018 and 2017 : Amount of (Loss)/Gain Recognized in Income on Derivative Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, Instrument Classification of (Loss)/Gain Recognized in Income on Derivative 2018 (1) 2017 (1) 2018 (1) 2017 (1) Interest rate swap agreements Interest (expense) $ (2 ) $ 11 $ (7 ) $ 20 (1) The amounts include a benefit of $8 million and $9 million for the three-month periods ending June 30, 2018 and 2017, respectively and a benefit of $16 million and $18 million for the six-months periods ending June 30, 2018 and 2017, respectively, relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships. The following table summarizes the effect of derivative instruments not designated as hedging instruments on the Consolidated Statements of Income for the three- and six-month periods ended June 30, 2018 and 2017 : Classification of Gain (Loss) Recognized in Income on Derivative Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, Instrument Classification of Gain (Loss) Recognized in Income on Derivative 2018 2017 2018 2017 Foreign exchange contracts Other income (expense), net $ 22 $ (19 ) $ 9 $ (42 ) The impact of gains and losses on foreign exchange contracts not designated as hedging instruments related to changes in the fair value of assets and liabilities denominated in foreign currencies are generally offset by net foreign exchange gains and losses, which are also included on the Consolidated Statements of Income in Other income (expense), net for all periods presented. When we enter into foreign exchange contracts not designated as hedging instruments to mitigate the impact of exchange rate volatility in the translation of foreign earnings, gains and losses will generally be offset by fluctuations in the U.S. Dollar translated amounts of each Income Statement account in current and/or future periods. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Three-Month Period Ended June 30, 2018 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 3,808 $ (192 ) $ 4 The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — 11 — Derivatives designated as hedging instruments (1) — (2 ) — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income (12 ) — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 7 — — Reclassification adjustment for excluded component (loss) gain (6 ) Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (1 ) — (1) The amounts include a benefit of $8 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the three-month period ending June 30, 2018. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Three-Month Period Ended June 30, 2017 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 3,259 $ (126 ) $ (31 ) The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — (2 ) — Derivatives designated as hedging instruments (1) — 11 — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income 81 — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 3 — 1 Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (2 ) — (1) The amounts include a benefit of $9 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the three-month period ending June 30, 2017. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Six-Month Period Ended June 30, 2018 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 7,339 $ (358 ) $ 969 The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — 25 — Derivatives designated as hedging instruments (1) — (7 ) — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income (38 ) — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 15 — — Reclassification adjustment for excluded component (loss) gain (17 ) — — Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (2 ) — (1) The amounts include a benefit of $16 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the six-month period ending June 30, 2018. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Six-Month Period Ended June 30, 2017 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 6,211 $ (253 ) $ (18 ) The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — (1 ) — Derivatives designated as hedging instruments (1) — 20 — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income 167 — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 5 — 8 Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (3 ) — Interest rate swap agreements: Amount of gain or (loss) reclassified from AOCI into income — (1 ) — (1) The amounts include a benefit of $18 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the six-month period ending June 30, 2017.

Cash, Cash Equivalents, Debt Se

Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values	6 Months Ended
	Jun. 30, 2018
Cash, Cash Equivalents, and Short-term Investments [Abstract]
Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values	Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values Time deposits, repurchase agreements, and commercial paper instruments with original maturities less than three months and money market funds are included in Cash and cash equivalents. As of June 30, 2018 , the carrying value of our time deposits and repurchase agreements was $11 million and money market funds was $507 million , all of which are included in Cash and cash equivalents. As of December 31, 2017 , the carrying value of our time deposits and repurchase agreements was $1.2 billion , commercial paper instruments was $35 million , and money market funds was $4.5 billion , all of which were included in Cash and cash equivalents. The carrying values approximated fair value as of June 30, 2018 and December 31, 2017 . Effective January 1, 2018, we adopted ASU 2016-01. Among other provisions, the new standard required modifications to existing presentation and disclosure requirements on a prospective basis. As such, certain disclosures as of December 31, 2017 below conform to the disclosure requirements prior to the adoption of ASU 2016-01. See Note 1 for additional information related to the adoption of ASU 2016-01. The amortized cost, gross unrealized holding gains, gross unrealized holding losses and estimated fair value of debt securities available-for-sale by major security type and class of security and equity investments with readily determinable fair values as of June 30, 2018 and December 31, 2017 were as follows: June 30, 2018 Amortized Cost Gross Unrealized Gain Gross Unrealized Loss Estimated Fair Value Time deposits (1) and Repurchase agreements (1) $ 79 $ — $ — $ 79 Total debt securities available-for-sale $ 79 $ — $ — $ 79 December 31, 2017 Amortized Cost Gross Unrealized Gain Gross Unrealized Loss Estimated Fair Value U.S. Treasury securities $ 445 $ — $ (3 ) $ 442 U.S. government-sponsored agency securities 42 — — 42 U.S. government-sponsored agency MBS 17 — — 17 Corporate debt - global 2,080 — (5 ) 2,075 Asset backed securities 203 — (1 ) 202 Ultra short income fund 352 — — 352 Time deposits (1) and Repurchase agreements (1) 89 — — 89 Total debt securities available-for-sale $ 3,228 $ — $ (9 ) $ 3,219 Equity securities with readily determinable fair values $ 935 $ 881 $ (6 ) $ 1,810 (1) Have original maturities of greater than three months. U.S. Treasury securities include government debt instruments issued by the U.S. Department of the Treasury. U.S. government-sponsored agency securities include general unsecured obligations either issued directly by or guaranteed by U.S. government sponsored enterprises. U.S. government-sponsored agency MBS include mortgage-backed securities issued by the Federal National Mortgage Association, the Federal Home Loan Mortgage Corporation and the Government National Mortgage Association. Corporate debt-global includes obligations issued by investment-grade corporations, including some issues that have been guaranteed by governments and government agencies. Asset backed securities consist of triple-A rated securities with cash flows collateralized by credit card receivables and auto loans. Ultra short income fund includes investments in certificates of deposit, repurchase agreements, commercial paper and corporate notes. Time deposits and repurchase agreements in the tables above have original maturities greater than three months. Our repurchase agreements are collateralized by U.S. government securities, cash, bonds, commercial paper and bank certificates of deposit. As of June 30, 2018 , all of our time deposits and repurchase agreements had original maturities less than one year. Equity securities with readily determinable fair values, which consist of investments in publicly traded equity securities, were $1,828 million as of June 30, 2018 . Duration periods of available-for-sale debt securities as of June 30, 2018 were as follows: Amortized Cost Fair Value Duration of one year or less $ 79 $ 79

Inventory

Inventory	6 Months Ended
	Jun. 30, 2018
Inventory Disclosure [Abstract]
Inventory	Inventory Inventories as of June 30, 2018 and December 31, 2017 are summarized by major category as follows: June 30, 2018 December 31, 2017 Raw materials $ 344 $ 289 Work in process 68 89 Finished goods 143 163 Total $ 555 $ 541

Intangible Assets and Goodwill

Intangible Assets and Goodwill	6 Months Ended
	Jun. 30, 2018
Goodwill and Intangible Assets Disclosure [Abstract]
Intangible Assets and Goodwill	Intangible Assets and Goodwill Intangible Assets: Our finite-lived intangible assets primarily consist of developed product rights and technology obtained from the Pharmion Corp. (Pharmion), Gloucester, Abraxis BioScience, Inc. (Abraxis), Avila, Quanticel and Juno acquisitions. The remaining weighted-average amortization period for finite-lived intangible assets not fully amortized is approximately 8.9 years . Our indefinite lived intangible assets consist of acquired IPR&D product rights from the Receptos Inc. (Receptos), Gloucester and Juno acquisitions. The gross carrying amount and accumulated amortization of intangible assets as of June 30, 2018 and December 31, 2017 are summarized as follows: June 30, 2018 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (2,087 ) $ 1,319 Technology 1,743 (474 ) 1,269 Licenses 66 (32 ) 34 Other 54 (37 ) 17 5,269 (2,630 ) 2,639 Non-amortizable intangible assets: Acquired IPR&D product rights 13,831 — 13,831 Total intangible assets $ 19,100 $ (2,630 ) $ 16,470 December 31, 2017 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (1,939 ) $ 1,467 Technology 483 (410 ) 73 Licenses 66 (30 ) 36 Other 43 (34 ) 9 3,998 (2,413 ) 1,585 Non-amortizable intangible assets: Acquired IPR&D product rights 6,851 — 6,851 Total intangible assets $ 10,849 $ (2,413 ) $ 8,436 The increase in the gross carrying value of intangible assets during the six-month period ended June 30, 2018 was primarily due to the addition of approximately $7.0 billion of IPR&D and $1.3 billion of a technology platform asset from the Juno acquisition. The economic useful life of the technology platform asset is 15 years (see Note 3). Amortization expense related to intangible assets was $129 million and $89 million for the three-month periods ended June 30, 2018 and 2017 , respectively and $217 million and $173 million for the six-month periods ended June 30, 2018 and 2017 . Effective for the second quarter of 2018, we reduced the remaining estimated useful life of our ABRAXANE ® intangible assets, which will result in full amortization by 2022 in conjunction with the recent settlements of patent-related proceedings (see Note 16). Assuming no changes in the gross carrying amount of finite-lived intangible assets, the future annual amortization expense related to intangible assets is expected to be approximately $474 million in 2018, $442 million in 2019, $440 million in 2020, $438 million in 2021 and $179 million in 2022. Goodwill: The carrying value of goodwill increased to approximately $8.0 billion as of June 30, 2018 compared to December 31, 2017 due to the acquisition of Juno (see Note 3).

Debt

Debt	6 Months Ended
	Jun. 30, 2018
Debt Disclosure [Abstract]
Debt	Debt Short-Term Borrowings and Current Portion of Long-Term Debt: The carrying value of short-term borrowings and current portion of long-term debt as of June 30, 2018 and December 31, 2017 includes: June 30, 2018 December 31, 2017 Commercial paper $ 995 $ — 2.250% senior notes due 2019 502 — Total short-term borrowings and current portion of long-term debt $ 1,497 $ — Long-Term Debt: Our outstanding senior notes with maturity dates in excess of one year after June 30, 2018 have an aggregate principal amount of $19.850 billion with varying maturity dates and interest rates. The carrying values of the long-term portion of these senior notes as of June 30, 2018 and December 31, 2017 includes: June 30, 2018 December 31, 2017 2.250% senior notes due 2019 $ — $ 505 2.875% senior notes due 2020 1,496 1,495 3.950% senior notes due 2020 511 514 2.250% senior notes due 2021 497 497 2.875% senior notes due 2021 498 — 3.250% senior notes due 2022 1,039 1,044 3.550% senior notes due 2022 995 994 2.750% senior notes due 2023 746 746 3.250% senior notes due 2023 993 — 4.000% senior notes due 2023 734 737 3.625% senior notes due 2024 1,001 1,001 3.875% senior notes due 2025 2,472 2,478 3.450% senior notes due 2027 974 991 3.900% senior notes due 2028 1,486 — 5.700% senior notes due 2040 247 247 5.250% senior notes due 2043 393 393 4.625% senior notes due 2044 987 987 5.000% senior notes due 2045 1,975 1,975 4.350% senior notes due 2047 1,234 1,234 4.550% senior notes due 2048 1,476 — Total long-term debt $ 19,754 $ 15,838 As of June 30, 2018 and December 31, 2017 , the fair value of our outstanding Senior Notes was approximately $19.6 billion and $16.6 billion , respectively, and represented a level 2 measurement within the fair value measurement hierarchy. Debt Issuance: In February 2018, we issued $500 million principal amount of 2.875% senior notes due 2021 (2021 Notes), $1.000 billion principal amount of 3.250% senior notes due 2023 (2023 Notes), $1.500 billion principal amount of 3.900% senior notes due 2028 (2028 Notes) and $1.500 billion principal amount of 4.550% senior notes due 2048 (2048 Notes). The 2021 Notes, 2023 Notes, 2028 Notes and 2048 Notes were issued at 99.954% , 99.758% , 99.656% and 99.400% of par, respectively, and the discount is being amortized as additional interest expense over the period from issuance through maturity. Offering costs of approximately $32 million were recorded as a direct deduction from the carrying amount of the 2021 Notes, 2023 Notes, 2028 Notes and 2048 Notes on our Consolidated Balance Sheet. The offering costs are being amortized as additional interest expense using the effective interest rate method over the period from issuance through maturity. Interest on the 2021 Notes is payable semi-annually in arrears on February 19 and August 19 of each year, beginning August 19, 2018 and the principal is due in full at the maturity date. Interest on the 2023 Notes, 2028 Notes and 2048 Notes is payable semi-annually in arrears on February 20 and August 20 of each year, beginning August 20, 2018 and the principal is due in full at the maturity date. The 2021 Notes, 2023 Notes, 2028 Notes and 2048 Notes may be redeemed at our option, in whole or in part, at any time at a redemption price equaling accrued and unpaid interest plus the greater of 100% of the principal amount of the Notes to be redeemed or the sum of the present values of the remaining schedule payments of interest and principal discounted to the date of redemption on a semi-annual basis plus 10 basis points for the 2021 Notes, 15 basis points for the 2023 Notes, 20 basis points for the 2028 Notes and 25 basis points for the 2048 Notes. If we experience a change of control accompanied by a downgrade of the debt to below investment grade, we will be required to offer to repurchase the 2021 Notes, 2023 Notes, 2028 Notes and 2048 Notes at a purchase price equal to 101% of the principal amount plus accrued and unpaid interest. We are subject to covenants which limit our ability to pledge properties as security under borrowing arrangements and limit our ability to perform sale and leaseback transactions involving our property. From time to time, we have used treasury rate locks and forward starting interest rate swap contracts to hedge against changes in interest rates in anticipation of issuing fixed-rate notes. As of June 30, 2018 , and December 31, 2017 a balance of $33 million and $31 million , respectively, in net losses remained in accumulated OCI related to the settlement of these derivative instruments and will be recognized as interest expense over the life of the notes. As of June 30, 2018 , we were party to pay-floating, receive-fixed interest rate swap contracts designated as fair value hedges of fixed-rate notes as described in Note 7. Our swap contracts outstanding as of June 30, 2018 effectively converted the hedged portion of our fixed-rate notes to floating rates. From time to time, we terminate the hedging relationship on certain of our swap contracts by settling the contracts or by entering into offsetting contracts. Any net proceeds received or paid in these settlements are accounted for as a reduction or increase of current and future interest expense associated with the previously hedged notes. As of June 30, 2018 and December 31, 2017 , we had balances of $125 million and $139 million , respectively, of unamortized gains recorded as a component of our debt as a result of past swap contract settlements. See Note 7 for additional details related to interest rate swap contract activity. Commercial Paper: As of June 30, 2018 and December 31, 2017 , we had available capacity to issue up to $2.0 billion of Commercial Paper. The carrying value of Commercial Paper as of June 30, 2018 was $995 million . As of December 31, 2017 there were no borrowings under the program. The effective interest rate on our outstanding Commercial Paper as of June 30, 2018 was 2.3% Senior Unsecured Credit Facility: We maintain a senior unsecured revolving credit facility (Credit Facility) that provides revolving credit in the aggregate amount of $2.0 billion . During the second quarter of 2018, we amended our Credit Facility to extend the expiration date to April 25, 2023. Amounts may be borrowed in U.S. Dollars for general corporate purposes. The Credit Facility currently serves as backup liquidity for our commercial paper borrowings. As of June 30, 2018 and December 31, 2017 , there was no outstanding borrowings against the Credit Facility. The Credit Facility contains affirmative and negative covenants, including certain customary financial covenants. We were in compliance with all financial covenants as of June 30, 2018 .

Share-Based Compensation

Share-Based Compensation	6 Months Ended
	Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Share-Based Compensation	Share-Based Compensation We have stockholder-approved stock incentive plans, the Celgene Corporation 2017 Stock Incentive Plan and the 2014 Equity Incentive Plan (formerly known as the Juno Therapeutics, Inc. 2014 Equity Incentive Plan) (collectively, the Plans) that provide for the granting of options, restricted stock units (RSUs), performance stock units (PSUs) and other share-based and performance- based awards to our employees, officers and non-employee directors. The Management Compensation and Development Committee of the Board of Directors (Compensation Committee) may determine the type, amount and terms, including vesting, of any awards made under the Plans. Shares of common stock available for future share-based grants under the 2014 Equity Incentive Plan were 13.9 million at the Acquisition Date. The following table summarizes the components of share-based compensation expense in the Consolidated Statements of Income for the three- and six-month periods ended June 30, 2018 and 2017 : Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Cost of goods sold (excluding amortization of acquired intangible assets) $ 9 $ 8 $ 18 $ 15 Research and development (1) 157 70 356 135 Selling, general and administrative (2) 118 92 311 173 Total share-based compensation expense 284 170 685 323 Tax benefit related to share-based compensation expense 37 46 74 87 Reduction in net income $ 247 $ 124 $ 611 $ 236 (1) The three- and six-month periods ended June 30, 2018 include Juno related share-based compensation expense related to the post-combination service period of $100 million and $233 million , respectively. (2) The three- and six-month periods ended June 30, 2018 include Juno related share-based compensation expense related to the post-combination service period of $50 million and $167 million , respectively. The tax benefit related to share-based compensation expense above excludes excess tax benefits of $5 million and $95 million from share-based compensation awards that vested or were exercised during the three-month periods ended June 30, 2018 and 2017, respectively, and $16 million and $170 million for the six-month periods ended June 30, 2018 , and 2017, respectively. The following table summarizes the activity for stock options, RSUs and PSUs for the six-month period ended June 30, 2018 (in millions unless otherwise noted): Stock Options RSUs PSUs (in thousands) Outstanding as of December 31, 2017 67.8 7.7 558 Changes during the Year: Conversion of Juno awards 3.7 2.5 336 Granted 6.8 3.4 162 Exercised / Released (3.5 ) (2.1 ) (247 ) Forfeited (1.8 ) (0.4 ) (28 ) Outstanding as of June 30, 2018 73.0 11.1 781 Total compensation cost related to unvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized as of June 30, 2018 were as follows (dollars in millions): Stock Options RSUs PSUs Unrecognized compensation cost $ 641 $ 566 $ 43 Expected weighted-average period in years of compensation cost to be recognized 2.2 1.9 1.5

Income Taxes

Income Taxes	6 Months Ended
	Jun. 30, 2018
Income Tax Disclosure [Abstract]
Income Taxes	Income Taxes We adopted ASU 2016-01, ASU 2016-16 and ASU 2018-2, effective January 1, 2018. See Note 1 for additional information related to the adoption of these accounting standard updates. The 2017 Tax Act was enacted on December 22, 2017 which reduced the U.S. statutory tax rate from 35% to 21% beginning in 2018. The 2017 Tax Act requires companies to pay a one-time transition tax on earnings of certain foreign subsidiaries that were previously tax deferred and introduces a new U.S. tax on certain off-shore earnings referred to as Global Intangible Low-Taxed Income (GILTI) beginning in 2018. We are applying the guidance issued by the Securities and Exchange Commission (SEC) in Staff Accounting Bulletin 118 when accounting for the enactment-date effects of the 2017 Tax Act. The guidance provides for a measurement period up to one year in which provisional amounts may be adjusted as an income tax expense or benefit in the period the adjustment is determined. As of June 30, 2018, we have not completed our accounting for the tax effects of the 2017 Tax Act and the provisional amounts recorded at December 31, 2017 were not adjusted during the quarter ended June 30, 2018. We will continue to analyze the impact of the 2017 Tax Act during the accounting measurement period. Our actual results may materially differ from our current estimates due to, among other things, further guidance that may be issued by U.S. tax authorities or regulatory bodies to interpret the 2017 Tax Act. The FASB allows companies to adopt an accounting policy to either recognize deferred taxes for GILTI or treat such as a tax cost in the year incurred. We have not yet determined our tax accounting policy and we have included in current income tax expense an amount related to our estimate of 2018 current year GILTI. We regularly evaluate the likelihood of the realization of our deferred tax assets and reduce the carrying amount of those deferred tax assets by a valuation allowance to the extent we believe a portion will not be realized. We consider many factors when assessing the likelihood of future realization of our deferred tax assets, including recent cumulative earnings experience by taxing jurisdiction, expectations of future taxable income, the carryforward periods available to us for tax reporting purposes and other relevant factors. Significant judgment is required in making this assessment. Our tax returns are under routine examination in many taxing jurisdictions. The scope of these examinations includes, but is not limited to, the review of our taxable presence in a jurisdiction, our deduction of certain items, our claims for research and development credits, our compliance with transfer pricing rules and regulations and the inclusion or exclusion of amounts from our tax returns as filed. Our U.S. federal income tax returns have been audited by the Internal Revenue Service (IRS) through the year ended December 31, 2008. Tax returns for the years ended December 31, 2009, 2010 and 2011 are currently under examination by the IRS. We are also subject to audits by various state and foreign taxing authorities, including most U.S. states and countries where we have operations. We regularly reevaluate our tax positions and the associated interest and penalties, if applicable, resulting from audits of federal, state and foreign income tax filings, as well as changes in tax law (including regulations, administrative pronouncements, judicial precedents, etc.) that would reduce the technical merits of the position to below more likely than not. We believe that our accruals for tax liabilities are adequate for all open years. Many factors are considered in making these evaluations, including past history, recent interpretations of tax law and the specifics of each matter. Because tax regulations are subject to interpretation and tax litigation is inherently uncertain, these evaluations can involve a series of complex judgments about future events and can rely heavily on estimates and assumptions. We apply a variety of methodologies in making these estimates and assumptions, which include studies performed by independent economists, advice from industry and subject matter experts, evaluation of public actions taken by the IRS and other taxing authorities, as well as our industry experience. These evaluations are based on estimates and assumptions that have been deemed reasonable by management. However, if management’s estimates are not representative of actual outcomes, our results of operations could be materially impacted. Unrecognized tax benefits, generally represented by liabilities on the Consolidated Balance Sheets and all subject to tax examinations, arise when the estimated benefit recorded in the financial statements differs from the amounts taken or expected to be taken in a tax return because of the uncertainties described above. These unrecognized tax benefits relate primarily to issues common among multinational corporations. Virtually all of these unrecognized tax benefits, if recognized, would impact the effective income tax rate. We account for interest and potential penalties related to uncertain tax positions as part of our provision for income taxes. For the six-month period ended June 30, 2018 gross unrecognized tax benefits increased by $200 million , including interest, primarily due to prior year tax positions. Of this amount, $38 million was an increase to income tax expense during the six-month period ended June 30, 2018 and the remainder were adjustments to non-current assets and non-current liabilities. The liability for unrecognized tax benefits is expected to increase in the next 12 months relating to operations occurring in that period. Any settlements of examinations with taxing authorities or statute of limitations expirations would likely result in a decrease in our liability for unrecognized tax benefits and a corresponding increase in taxes paid or payable and/or a decrease in income tax expense. It is reasonably possible that the amount of the liability for unrecognized tax benefits could change by a significant amount during the next twelve-month period as a result of settlements or statute of limitations expirations. Finalizing examinations with the relevant taxing authorities can include formal administrative and legal proceedings and, as a result, it is difficult to estimate the timing and range of possible change related to the Company’s unrecognized tax benefits. An estimate of the range of possible change cannot be made until issues are further developed or examinations close. Our estimates of tax benefits and potential tax benefits may not be representative of actual outcomes and variation from such estimates could materially affect our consolidated financial statements in the period of settlement or when the statutes of limitations expire.

Collaboration Agreements

Collaboration Agreements	6 Months Ended
	Jun. 30, 2018
Collaboration Agreements [Abstract]
Collaboration Agreements	Collaboration Arrangements We enter into collaborative arrangements for the research and development, license, manufacture and/or commercialization of products and/or product candidates. In addition, we also acquire products, product candidates and research and development technology rights and establish research and development collaborations with third parties to enhance our strategic position within our industry by strengthening and diversifying our research and development capabilities, product pipeline and marketed product base. These arrangements may include non-refundable, upfront payments, payments by us for options to acquire rights to products and product candidates and other rights, as well as contingent obligations by us for potential development, regulatory and commercial performance milestone payments, cost sharing arrangements, royalty payments, profit sharing and equity investments (including equity investments in the event of an initial public offering of equity by our partners). The activities under these collaboration agreements are performed with no guarantee of either technological or commercial success. Although we do not consider any individual alliance to be material, certain of the more notable alliances are described in Note 17 of Notes to Consolidated Financial Statements included in our 2017 Annual Report on Form 10-K. The following is a brief description for notable new collaborations and for those collaborations which we have described in detail in our 2017 Annual Report on Form 10-K if there has been significant activity during the six months ended June 30, 2018 . Amounts related to collaborations that are not specifically presented are included in the aggregate as Other Collaboration Arrangements. Lycera Corp. (Lycera): In June 2018, our collaboration and option agreement with Lycera expired. As a result, we do not have an exclusive right to acquire Lycera. We have retained our equity interest in Lycera, an exclusive license for Lycera’s portfolio of novel ex-vivo RORγ agonist compounds and an exclusive license for Lycera’s RORγ antagonist compounds. Prothena Corporation plc (Prothena): On March 20, 2018, we entered into a collaboration agreement with Prothena to develop new therapies for a broad range of neurodegenerative diseases. The collaboration is focused on three proteins implicated in the pathogenesis of several neurodegenerative diseases, including tau, TDP-43 and an undisclosed target. In addition, we purchased approximately 1.2 million of Prothena's ordinary shares. We made a total payment of $150 million , which was accounted for as a $40 million equity investment with a readily determinable fair value and $110 million as upfront collaboration consideration that was expensed immediately as research and development. For each of the programs, we have an exclusive right to license clinical candidates in the U.S. at the investigational new drug (IND) filing and if exercised, would also have a right to expand the license to global rights at the completion of Phase 1. Following the exercise of global rights, we will be responsible for funding all further global clinical development and commercialization. Prothena may receive future potential exercise payments and regulatory and commercial milestones for each licensed program. Prothena will also receive additional royalties on net sales of any resulting marketed products. The collaboration agreement has an initial term of six years , which may be extended up to two additional years. The collaboration agreement may be terminated at our discretion upon 60 days prior written notice to Prothena and by either party upon material breach of the other party, subject to cure periods. A financial summary of certain period activity and the period-end balances related to Prothena is presented below (1) : Six-Month Period Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 110 $ — $ — $ — $ 40 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ — $ 17 2.9 % (1) There was no collaboration activity related to Prothena during the three-month period ended June 30, 2018. In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us. Vividion Therapeutics, Inc. (Vividion): On March 1, 2018, we entered into a collaboration agreement with Vividion for the identification and development of small molecules against targets for a range of oncology, inflammatory and neurodegenerative indications. In addition, we purchased an immaterial amount of Vividion's Series A-3 preferred shares. We made a total upfront payment of $101 million , which was accounted for as a $4 million equity investment without a readily determinable fair value and $97 million as upfront collaboration consideration that was expensed immediately as research and development. Vividion will lead initial discovery efforts and identification of programs to be included in the collaboration, and we have the right to opt in on certain programs at a defined stage of development. For certain programs, including the first program, we will have the exclusive worldwide rights, with the potential for Vividion to receive up to double-digit royalties on sales and milestone payments. In accordance with the collaboration agreement, other programs will allow for us and Vividion to share equally either U.S. or worldwide development costs and profits and losses. The collaboration agreement has an initial term of four years, which may be extended up to two additional years. The collaboration agreement may be terminated at our discretion upon 90 days prior written notice to Vividion and by either party upon material breach of the other party, subject to cure periods. A financial summary of certain period activity and the period-end balances related to Vividion is presented below (1) : Six-Month Period Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 97 $ — $ — $ — $ 4 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ — $ 4 5.8 % (1) There was no collaboration activity related to Vividion during the three-month period ended June 30, 2018. In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us. Other Collaboration Arrangements in 2018: In addition to the collaboration arrangements described above, we entered into collaboration arrangements for the three- and six-month periods ended June 30, 2018 that include the potential for future milestone payments of $177 million related to the attainment of specified development, regulatory and sales milestones over a period of several years. Our obligation to fund these efforts is contingent upon our continued involvement in the programs and/or the lack of any adverse events which could cause the discontinuance of the programs. A financial summary of certain period activity and the period-end balances related to our other collaboration arrangements is presented below (1) : Three-Month Periods Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 146 $ 15 $ 4 $ 2 $ 20 2017 75 — — 3 67 Six-Month Periods Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 184 $ 15 $ 4 $ 4 $ 77 2017 85 — 7 7 79 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ 7 $ 1,710 N/A December 31, 2017 12 1,806 N/A (1) In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us. In addition to the collaboration arrangements described above, in conjunction with the acquisition of Juno we assumed Juno's legacy collaboration arrangements including Fred Hutchinson Cancer Research Center and Memorial Sloan Kettering Cancer Center.

Commitments and Contingencies

Commitments and Contingencies	6 Months Ended
	Jun. 30, 2018
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Collaboration Arrangements and Acquired Research and Development Assets: We have entered into certain research and development collaboration arrangements with third parties that include our funding of certain development, manufacturing and commercialization efforts and the potential for making future milestone and royalty payments upon the achievement of pre-established developmental, regulatory and/or commercial targets. In addition, we have also made certain acquisitions that included potential future development, regulatory and commercial milestones. Our obligation to fund these efforts and make milestone payments is contingent upon our continued involvement in the programs and/or the lack of any adverse events which could cause the discontinuance of the programs. Due to the nature of these arrangements, the future potential payments are inherently uncertain, and accordingly no amounts have been recorded for the potential future achievement of these targets in our accompanying Consolidated Balance Sheets as of June 30, 2018 and December 31, 2017 . With our acquisition of Juno, we have assumed additional research and development collaboration arrangements with third parties that include our funding of certain development, manufacturing and commercialization efforts and the potential for making future milestone and royalty payments upon the achievement of pre-established developmental, regulatory and/or commercial targets. See Note 3 for additional details related to our acquisitions and Note 14 for additional details related to collaboration arrangements. Contingencies: We believe we maintain insurance coverage adequate for our current needs. Our operations are subject to environmental laws and regulations which, among other things, impose limitations on the discharge of pollutants into the air and water and establish standards for the treatment, storage and disposal of solid and hazardous wastes. We review the effects of such laws and regulations on our operations and modify our operations as appropriate. We believe we are in substantial compliance with all applicable environmental laws and regulations. We have ongoing customs, duties and value-added-tax examinations in various countries that have yet to be settled. Based on our knowledge of the claims and facts and circumstances to date, none of these matters, individually or in the aggregate, are deemed to be material to our financial condition.

Legal Proceedings

Legal Proceedings	6 Months Ended
	Jun. 30, 2018
Commitments and Contingencies Disclosure [Abstract]
Legal Proceedings	Legal Proceedings Like many companies in our industry, we have, from time to time, received inquiries and subpoenas and other types of information requests from government authorities and others and we have been subject to claims and other actions related to our business activities. While the ultimate outcome of investigations, inquiries, information requests and legal proceedings is difficult to predict, adverse resolutions or settlements of those matters may result in, among other things, modification of our business practices, product recalls, costs and significant payments, which may have a material adverse effect on our results of operations, cash flows or financial condition. Pending patent proceedings include challenges to the scope, validity and/or enforceability of our patents relating to certain of our products, uses of products or processes. Further, as certain of our products mature or they near the end of their regulatory exclusivity periods, it is more likely that we will receive challenges to our patents, and in some jurisdictions we have received such challenges. We are also subject, from time to time, to claims of third parties that we infringe their patents covering products or processes. Although we believe we have substantial defenses to these challenges and claims, there can be no assurance as to the outcome of these matters and an adverse decision in these proceedings could result in one or more of the following: (i) a loss of patent protection, which could lead to a significant reduction of sales that could materially affect our future results of operations, cash flows or financial condition; (ii) our inability to continue to engage in certain activities; and (iii) significant liabilities, including payment of damages, royalties and/or license fees to any such third party. Among the principal matters pending are the following: Patent-Related Proceedings: REVLIMID ® : In 2012, our European patent EP 1 667 682 (the ’682 patent) relating to certain polymorphic forms of lenalidomide expiring in 2024 was opposed in a proceeding before the European Patent Office (EPO) by Generics (UK) Ltd. and Teva Pharmaceutical Industries Ltd. On July 21, 2015, the EPO determined that the ’682 patent was not valid. Celgene appealed the EPO ruling to the EPO Board of Appeal, thereby staying any revocation of the patent until the appeal is finally adjudicated. No appeal hearing date has been set. We believe that our patent portfolio for lenalidomide in Europe, including the composition of matter patent which expires in 2022, is strong. In the event that we do not prevail on the appeal relating to the ’682 patent, we still expect that we will have protection in the EU for lenalidomide until at least 2022. In June 2017, Accord Healthcare Ltd. (Accord) commenced lawsuits against us in the United Kingdom (UK) seeking to revoke our UK patents protecting REVLIMID ® . In June 2018, we entered into a settlement agreement with Accord resolving the lawsuits. We received a Notice of Allegation dated June 13, 2017 from Dr. Reddy’s Laboratories Ltd. (DRL) notifying us of the filing of DRL’s Abbreviated New Drug Submission (ANDS) with Canada’s Minister of Health, with respect to Canadian Letters Patent Nos. 2,261,762; 2,476,983; 2,477,301; 2,537,092; 2,687,924; 2,687,927; 2,688,694; 2,688,695; 2,688,708; 2,688,709; 2,741,412; and 2,741,575. DRL is seeking to manufacture and market a generic version of 5mg, 10mg, 15mg, 20mg, and 25mg REVLIMID ® (lenalidomide) capsules in Canada. We commenced a proceeding in the Federal Court of Canada on July 27, 2017, seeking an order prohibiting the Minister of Health from granting marketing approval to DRL until expiry of these patents. We received a further Notice of Allegation dated September 20, 2017 from DRL relating to the same submission, but also referencing 2.5mg REVLIMID ® (lenalidomide) capsules. DRL’s Notices of Allegation contains invalidity allegations relating to Canadian Letters Patent Nos. 2,537,092; 2,687,924; 2,687,927; 2,688,694; 2,688,695; 2,688,708; 2,688,709; 2,741,412; and 2,741,575. We commenced a proceeding in the Federal Court of Canada on November 2, 2017, seeking an order prohibiting the Minister of Health from granting marketing approval to DRL until expiry of these patents. The hearings for these proceedings are scheduled for September 23-24, 2019 and September 30-October 3, 2019, respectively. We received a Notice Letter dated September 9, 2016 from DRL notifying us of its Abbreviated New Drug Application (ANDA) which contains Paragraph IV certifications against U.S. Patent Nos. 7,465,800; 7,855,217; 7,968,569; 8,530,498; 8,648,095; 9,101,621; and 9,101,622 that are listed in the U.S. Food and Drug Administration (FDA) list of Approved Drug Products with Therapeutic Equivalence Evaluations, commonly referred to as the Orange Book (Orange Book), for REVLIMID ® . DRL is seeking to manufacture and market a generic version of 2.5mg, 5mg, 10mg, 15mg, 20mg, and 25mg REVLIMID ® (lenalidomide) capsules in the United States. In response to the Notice Letter, we timely filed an infringement action against DRL in the U.S. District Court for the District of New Jersey on October 20, 2016. As a result of the filing of our action, the FDA cannot grant final approval of DRL's ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) March 10, 2019. On November 18, 2016, DRL filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. On December 27, 2016, we filed a reply to DRL’s counterclaims. Fact discovery is set to close on August 31, 2018. The court has not yet entered a schedule for expert discovery or trial. We received an additional Notice Letter from DRL dated June 8, 2017 notifying us of additional Paragraph IV certifications against U.S. Patent Nos. 7,189,740; 8,404,717; and 9,056,120 that are listed in the Orange Book for REVLIMID ® . In response to that Notice Letter, we timely filed an infringement action against DRL in the U.S. District Court for the District of New Jersey on July 20, 2017. As a result of the filing of our action, the FDA cannot grant final approval of DRL's ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) December 9, 2019. On October 18, 2017, DRL filed an amended answer and counterclaims asserting that each of the patents is invalid and/or not infringed. We filed our reply to DRL’s counterclaims on November 15, 2017. Fact discovery is set to close on March 15, 2019. The court has not yet entered a schedule for expert discovery or trial. We received another Notice Letter from DRL dated February 26, 2018 notifying us of additional Paragraph IV certifications against U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886; and 8,626,531 that are listed in the Orange Book for REVLIMID®. In response to the Notice Letter, we timely filed an infringement action against DRL in the U.S. District Court for the District of New Jersey on April 12, 2018. As a result of the filing of our action, the FDA cannot grant final approval of DRL's ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) August 27, 2020. DRL filed an amended answer and counterclaims on May 31, 2018 asserting that each of the patents is invalid and/or not infringed. We filed our reply to DRL’s counterclaims on June 28, 2018. The court has not yet entered a schedule for fact discovery, expert discovery, or trial. We received a Notice Letter dated February 27, 2017 from Zydus Pharmaceuticals (USA) Inc. (Zydus) notifying us of Zydus’ ANDA which contains Paragraph IV certifications against U.S. Patent Nos. 7,465,800; 7,855,217; 7,968,569; 8,530,498; 8,648,095; 9,101,621; and 9,101,622 that are listed in the Orange Book for REVLIMID ® . Zydus is seeking to manufacture and market a generic version of 2.5 mg, 5 mg, 10 mg, 15 mg, 20 mg, and 25mg REVLIMID ® (lenalidomide) capsules in the United States. In response to the Notice Letter, we timely filed an infringement action against Zydus in the U.S. District Court for the District of New Jersey on April 12, 2017. As a result of the filing of our action, the FDA cannot grant final approval of Zydus’ ANDA at least until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) August 28, 2019. On August 7, 2017, Zydus filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. On September 11, 2017, we filed a reply to Zydus’s counterclaims. Fact discovery is set to close on March 15, 2019. The court has yet to enter a schedule for expert discovery and trial. On April 27, 2018, we filed another infringement action against Zydus in the U.S. District Court for the District of New Jersey. The patents-in-suit are U.S. Patent Nos. 7,977,357; 8,193,219 and 8,431,598, which are patents not listed in the Orange Book. Zydus filed its answer on July 9, 2018 asserting that each of the patents is invalid and/or not infringed. The court has not yet entered a schedule for fact discovery, expert discovery, or trial. We received a Notice Letter dated June 30, 2017 from Cipla Ltd., India (Cipla) notifying us of Cipla’s ANDA which contains Paragraph IV certifications against U.S. Patent Nos. 7,465,800; 7,855,217; 7,968,569; 8,530,498; 8,648,095; 9,101,621 and 9,101,622 that are listed in the Orange Book for REVLIMID ® . Cipla is seeking to manufacture and market a generic version of 5mg, 10mg, 15mg, 20mg, and 25mg REVLIMID ® (lenalidomide) capsules in the United States. In response to the Notice Letter, on August 15, 2017, we timely filed an infringement action against Cipla in the U.S. District Court for the District of New Jersey. As a result of the filing of our action, the FDA cannot grant final approval of Cipla’s ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) January 5, 2020. On October 13, 2017, Cipla filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. We filed our reply to Cipla’s counterclaims on November 17, 2017. Fact discovery is set to close on March 15, 2019. The court has yet to enter a schedule for expert discovery and trial. On May 8, 2018, we filed another infringement action against Cipla in the U.S. District Court for the District of New Jersey. The patents-in-suit are U.S. Patent Nos. 7,977,357; 8,193,219 and 8,431,598, which are patents that are not listed in the Orange Book. Cipla has not yet responded to the complaint. We received a Notice Letter dated July 24, 2017 from Lotus Pharmaceutical Co., Inc. (Lotus) notifying us of Lotus’s ANDA which contains Paragraph IV certifications against U.S. Patent Nos. 5,635,517; 6,315,720; 6,561,977; 6,755,784; 7,189,740; 7,465,800; 7,855,217; 7,968,569; 8,315,886; 8,404,717; 8,530,498; 8,626,531; 8,648,095; 9,056,120; 9,101,621; and 9,101,622 that are listed in the Orange Book for REVLIMID ® . Lotus is seeking to manufacture and market a generic version of 2.5mg, 5mg, 10mg, 15mg, 20mg, and 25mg REVLIMID ® (lenalidomide) capsules in the United States. In response to the Notice Letter, we timely filed an infringement action against Lotus in the U.S. District Court for the District of New Jersey on September 6, 2017. As a result of the filing of our action, the FDA cannot grant final approval of Lotus’s ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) January 25, 2020. On October 5, 2017, Lotus filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. We filed our reply to Lotus’s counterclaims on November 9, 2017. Fact discovery is set to close on March 15, 2019. The court has yet to enter a schedule for expert discovery and trial. On July 10, 2018, we filed another infringement action against Lotus in the U.S. District Court for the District of New Jersey. The patents-in-suit are U.S. Patent Nos. 7,977,357; 8,193,219 and 8,431,598, which are patents that are not listed in the Orange Book. Lotus has not yet responded to the complaint. We received a Notice Letter dated November 28, 2017 from Apotex Inc. (Apotex) notifying us of Apotex’s ANDA, which contains Paragraph IV certifications against U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 7,465,800; 7,468,363; 7,855,217; 8,315,886; 8,626,531; and 8,741,929 that are listed in the Orange Book for REVLIMID ® . Apotex is seeking to manufacture and market a generic version of 2.5mg, 5mg, 10mg, 15mg, 20mg, and 25mg REVLIMID ® (lenalidomide) capsules in the United States. In response to the Notice Letter, we timely filed an infringement action against Apotex in the U.S. District Court for the District of New Jersey on January 11, 2018. As a result of the filing of our action, the FDA cannot grant final approval of Apotex’s ANDA until at least the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) May 29, 2020. On April 2, 2018, Apotex responded to the complaint by filing a motion to dismiss the case for failure to join a necessary party. We filed our response on May 21, 2018. Apotex filed its reply brief on June 11, 2018. The court has not yet decided Apotex's motion or entered a schedule for fact discovery, expert discovery, or trial. POMALYST ® : We received a Notice Letter dated March 30, 2017 from Teva Pharmaceuticals USA, Inc. (Teva) (the Teva Notice Letter) notifying us of Teva’s ANDA submitted to the FDA, which contains Paragraph IV certifications against U.S. Patent Nos. 6,316,471; 8,198,262; 8,673,939; 8,735,428 and 8,828,427 that are listed in the Orange Book for POMALYST ® . Teva is seeking to manufacture and market a generic version of 1 mg, 2 mg, 3 mg, and 4 mg POMALYST ® (pomalidomide) capsules in the United States. We later received similar Notice Letters (together with the Teva Notice Letter, the Pomalidomide Notice Letters) from other generic drug manufacturers -Apotex; Hetero USA, Inc. (Hetero); Aurobindo Pharma Ltd. (Aurobindo); Mylan Pharmaceuticals Inc. (Mylan); and Breckenridge Pharmaceutical, Inc. (Breckenridge) - relating to these and other POMALYST® patents listed in the Orange Book. In May 2018, we received a similar Notice Letter from Synthon Pharmaceuticals Inc. (the Synthon Notice Letter). In response to the Pomalidomide Notice Letters, we timely filed infringement actions in the U.S. District Court for the District of New Jersey against Teva on May 4, 2017 and against Apotex, Hetero, Aurobindo, Mylan, and Breckenridge on May 11, 2017. As a result of the filing of our actions, the FDA cannot grant final approval of these ANDAs at least until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) August 8, 2020. On July 13, 2017, Apotex and Hetero each filed answers and counterclaims asserting that each of the patents is invalid and/or not infringed, and further seeking declaratory judgments of noninfringement and invalidity for additional patents listed in the Orange Book for POMALYST ® , namely U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886 and 8,626,531. On August 17, 2017, we filed replies to Apotex’s and Hetero’s counterclaims, as well as counter-counterclaims against Apotex and Hetero asserting infringement of U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886 and 8,626,531. Apotex and Hetero filed replies to our counter-counterclaims on September 6 and September 8, 2017, respectively. On July 31, 2017, Breckenridge filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. We filed our reply to Breckenridge’s counterclaims on September 5, 2017. On December 6, 2017, Breckenridge filed an amended pleading to include counterclaims seeking declaratory judgments of noninfringement and invalidity for additional patents listed in the Orange Book for POMALYST ® , namely U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886 and 8,626,531. Celgene replied to Breckenridge’s amended counterclaims and asserted counter-counterclaims on January 3, 2018. On August 7, 2017, Teva filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. On September 11, 2017, we filed a reply to Teva’s counterclaims. On August 9, 2017, Mylan filed a motion to dismiss the complaint, and on March 2, 2018, the court denied Mylan’s motion to dismiss without prejudice and granted our request for venue-related discovery. On September 15, 2017, Aurobindo filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed, and further seeking declaratory judgments of noninfringement and invalidity for additional patents listed in the Orange Book for POMALYST ® , namely U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886; and 8,626,531. We filed our reply to Aurobindo’s counterclaims and counter-counterclaims concerning U.S. Patent Nos. 6,315,720; 6,561,977; 6,755,784; 8,315,886; and 8,626,531 on October 20, 2017. Aurobindo filed its answer to our counter-counterclaims on November 24, 2017. In response to the Synthon Notice Letter, we timely filed an infringement action against Synthon in the U.S. District Court for the District of New Jersey on June 19, 2018. As a result of the filing of our actions, the FDA cannot grant final approval of Synthon’s ANDA at least until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) November 7, 2020. On July 16, 2018, Synthon filed an answer and counterclaims asserting that each of the patents asserted in the complaint is invalid and/or not infringed. Fact discovery in the Apotex, Aurobindo, Breckenridge, Hetero, Mylan, and Teva cases is scheduled to close on March 1, 2019 and expert discovery in these cases is scheduled to close on September 30, 2019. Trial has not been scheduled in any POMALYST ® litigation. ABRAXANE ® : We received a Notice Letter dated February 23, 2016 from Actavis LLC (Actavis) notifying us of Actavis’s ANDA which contains Paragraph IV certifications against U.S. Patent Nos. 7,820,788; 7,923,536; 8,138,229; and 8,853,260 that are listed in the Orange Book for ABRAXANE ® . We then received a Notice Letter dated October 25, 2016 from Cipla notifying us of Cipla’s ANDA, which contains Paragraph IV certifications against the same four patents for ABRAXANE ® . Actavis and Cipla are each seeking to manufacture and market a generic version of ABRAXANE ® 100 mg/vial. On April 6, 2016, we filed an infringement action against Actavis in the U.S. District Court for the District of New Jersey. We entered into a settlement with Actavis, effective January 23, 2018, to terminate that patent litigation and Inter Partes Review (IPR) challenges between the parties relating to certain patents for ABRAXANE ® . As part of the settlement, the parties filed a Consent Judgment with the U.S. District Court for the District of New Jersey, which was entered on January 26, 2018, enjoining Actavis from marketing generic paclitaxel protein-bound particles for injectable suspension before expiration of the patents-in-suit, except as provided for in the settlement. In the settlement, we agreed to provide Actavis with a license to our patents required to manufacture and sell a generic paclitaxel protein-bound particles for injectable suspension product in the United States beginning on March 31, 2022. On December 7, 2016, we filed an infringement action against Cipla in the U.S. District Court for the District of New Jersey. As a result of the filing of our action, the FDA cannot grant final approval of Cipla’s ANDA until the earlier of (i) a final decision that each of the patents is invalid, unenforceable, and/or not infringed, and (ii) April 25, 2019. On January 20, 2017, Cipla filed an answer and counterclaims asserting that each of the patents is invalid and/or not infringed. Our reply was filed on February 24, 2017. The court has not yet set a date for trial. On January 13, 2017, the UK High Court of Justice handed down a ruling after a hearing held on December 20, 2016 in which we argued that the UK Intellectual Property Office improperly rejected our request for an SPC to the ABRAXANE ® patent UK No. 0 961 612 (the ’612 patent). In that ruling, the High Court referred the matter to the Court of Justice for the EU (CJEU). A hearing was held at the CJEU on June 21, 2018. We expect a decision from the CJEU later this year. If the CJEU were to find in our favor, the ruling would need to be implemented in other jurisdictions in which the proceedings are pending, potentially resulting in the grant of SPCs not only in the UK, but also in other jurisdictions that have previously rejected our initial request including Germany and Ireland. The ’612 patent expired in Europe in September 2017. However, if granted, the SPCs will expire in 2022. Data exclusivity in Europe will expire in January 2019. We received a Notice of Allegation (NOA) dated March 22, 2018 from Panacea Biotec Ltd. (Panacea) notifying us of the filing of Panacea’s ANDS with Canada’s Minister of Health, with respect to Canadian Letters Patent No. 2,509,365 (the '365 patent). Panacea is seeking to manufacture and market a generic version of 100 mg/vial ABRAXANE® (paclitaxel powder for injectable suspension, nanoparticle, albumin-bound (nab®) paclitaxel) in Canada. On May 4, 2018, our subsidiaries, Abraxis BioScience, LLC and Celgene Inc. commenced an action for patent infringement in the Federal Court of Canada seeking, among other relief, a declaration of infringement in relation to the ‘365 patent. In June 2018, Celgene and Apotex settled certain patent disputes involving ABRAXANE ® that were triggered by Apotex filing an ANDA in the United States, IPR patent challenges before the U.S. Patent Office (see below), and the aforementioned NOA filed by Apotex's marketing partner, Panacea. In addition to dismissing the patent proceedings, in the settlement we agreed to provide Apotex with a license to our patents required to manufacture and sell a generic paclitaxel protein-bound particles for injectable suspension product in the United States beginning on September 27, 2022, and in certain countries outside of the United States, including Canada, beginning on a later date. OTEZLA®: We received Notice Letters from each of the following companies between May 14, 2018 and June 8, 2018: Alkem Laboratories Ltd. (Alkem); Amneal Pharmaceuticals LLC (Amneal); Annora Pharma Private Ltd. (Annora); Aurobindo; Cipla; DRL and Dr. Reddy’s Laboratories, Inc.; Emcure Pharmaceuticals Ltd. (Emcure); Glenmark Pharmaceuticals Ltd. (Glenmark); Macleods Pharmaceuticals Ltd. (Macleods); Mankind Pharma Ltd. (Mankind); MSN Laboratories Private Ltd. (MSN); Pharmascience Inc. (Pharmascience); Prinston Pharmaceutical Inc. (Prinston); Sandoz Inc. (Sandoz); Shilpa Medicare Ltd. (Shilpa); Teva; Torrent Pharmaceuticals Ltd. (Torrent); Unichem Laboratories, Ltd. (Unichem); and Zydus notifying us of their ANDAs, which contain Paragraph IV certifications against one or more of the following patents: U.S. Patent Nos. 6,962,940; 7,208,516; 7,427,638; 7,659,302; 7,893,101; 8,455,536; 8,802,717; 9,018,243; and 9,872,854, which are listed in the Orange Book for OTEZLA®. Each of the companies is seeking to market a generic version of OTEZLA®. In response to the Notice Letters, we timely filed infringement actions in the U.S. District Court for the District of New Jersey. As a result of the filing of our actions, the FDA cannot grant final approval of any of these companies' ANDAs until the earlier of (i) a final decision that each of the asserted patents is invalid, unenforceable, and/or not infringed, and (ii) September 21, 2021. Juno patent-related proceedings: KITE: On October 18, 2017, the day on which the FDA approved Kite Pharma, Inc.’s (Kite) Yescarta™ KTE-C19 product, Juno filed a complaint against Kite in the U.S. District Court for the Central District of California. The complaint alleged that Yescarta™ infringes claims 1-3, 5, 7-9, and 11 of U.S. Patent No. 7,446,190 (the ’190 Patent). Kite answered the complaint on November 28, 2017, and filed counterclaims of non-infringement and invalidity against Juno. Juno filed a motion to dismiss Kite’s counterclaims and to strike certain affirmative defenses on December 19, 2017. On March 8, 2018, the court granted Juno’s motion to dismiss and strike, and ordered Kite to file an amended answer and counterclaims. On the same day, the court denied Kite’s motion to stay. On March 29, 2018, Kite filed an amended answer and counterclaims, asserting that the ’190 Patent is invalid and/or not infringed. On April 9, 2018, we filed an answer to Kite’s counterclaims. Fact and expert discovery are set to close on September 24, 2018 and December 10, 2018, respectively, and trial is scheduled to begin on March 26, 2019. CITY OF HOPE: On August 22, 2017, City of Hope (COH) filed a lawsuit against Juno in the U.S. District Court for the Central District of California alleging that Juno, prior to its acquisition by Celgene, breached an exclusive license agreement (ELA) between Juno and COH by sublicensing COH intellectual property to Celgene without COH’s consent and by failing to pay COH related sublicensing revenues. COH sought damages in an amount no less than $93.75 million in alleged sublicense revenues and a judicial declaration that the ELA has terminated. In July 2018, Juno and COH entered into a confidential settlement agreement dismissing the lawsuit and reinstating the ELA. The settlement amount was not materially different than the amount we had previously accrued for this matter. Proceedings involving the U.S. Patent and Trademark Office (USPTO): REMS IPR: Under the America Invents Act (AIA), any person may seek to challenge an issued patent by petitioning the USPTO to institute a post grant review. On April 23, 2015, we were informed that the Coalition for Affordable Drugs VI LLC filed petitions for IPR challenging the validity of our U.S. Patent Nos. 6,045,501 (the ’501 patent) and 6,315,720 (the ’720 patent) covering certain aspects of our REMS program. On October 27, 2015, the USPTO Patent Trial and Appeal Board (PTAB) instituted IPR proceedings relating to these patents. An oral hearing was held on July 21, 2016. The PTAB's decisions, rendered on October 26, 2016, held that the ’501 and ’720 patents are invalid, primarily due to obviousness in view of certain publications. On November 25, 2016, we requested a rehearing with respect to certain claims of these patents. On September 8, 2017, the PTAB denied our rehearing request for the ’501 patent, but granted our rehearing request pertaining to a certain claim of the ’720 patent. We timely appealed to the U.S. Court of Appeals for the Federal Circuit the PTAB’s determinations regarding certain claims of the ’720 patent and the ’501 patent on November 6, 2017 and on November 9, 2017, respectively. On February 26, 2018, the USPTO intervened in our appeal. Our opening briefs were filed on May 31, 2018. The ’501 and ’720 patents remain valid and enforceable pending appeal. We retain other patents covering certain aspects of our REMS program, as well as patents that cover our products that use our REMS system. ABRAXANE ® IPR: On April 4, 2017, Actavis filed petitions for IPRs challenging the validity of our U.S. Patent Nos. 8,138,229 (the ’229 patent); 7,923,536 (the ’536 patent); 7,820,788 (the ’788 patent); and 8,853,260 (the ’260 patent) covering certain aspects of our ABRAXANE ® product. On October 10, 2017, the PTAB instituted IPR proceedings on the ’229, ’536, and ’788 patents and on October 11, 2017 denied institution of the IPR on the ‘260 patent. On January 29, 2018, the parties submitted a joint motion to terminate all three IPRs in connection with the settlement entered into with Actavis mentioned above. On May 8, 2018, the PTAB granted the parties’ joint motion to terminate. On November 9, 2017, Apotex and Cipla each filed petitions for IPRs challenging the validity of the ’229, ’536, and’788 patents. On May 8, 2018, the PTAB denied institution of all IPRs. REVLIMID ® IPR : On February 23, 2018, Apotex filed a petition for IPR challenging the validity of our U.S. Patent Nos. 8,741,929 (the ’929 patent). Our preliminary response was filed on June 28, 2018. The PTAB has until September 28, 2018 to determine whether it will institute the IPR. JUNO IPR: On August 13, 2015, Kite filed a petition for IPR challenging the validity of U.S. Patent Nos. 7,446,190 (the ’190 Patent), exclusively licensed from Memorial Sloan Kettering Cancer Center. On February 11, 2016, the PTAB instituted the IPR proceedings. A hearing was held before the PTAB on October 20, 2016. On December 16, 2016, the PTAB issued a final written decision upholding all claims of the ’190 Patent. On February 16, 2017, Kite filed a notice of appeal of the PTAB’s final written decision to the U.S. Court of Appeals for the Federal Circuit. On June 6, 2018, the Federal Circuit affirmed the decision of the Patent Trial and Appeal Board, upholding all claims of the ’190 Patent. Other Proceedings: MYLAN: On April 3, 2014, Mylan filed a lawsuit against us in the U.S. District Court for the District of New Jersey alleging that we violated various federal and state antitrust and unfair competition laws by allegedly refusing to sell samples of our THALOMID ® and REVLIMID ® brand drugs so that Mylan may conduct the bioequivalence testing necessary to submit ANDAs to the FDA for approval to market generic versions of these products. Mylan is seeking injunctive relief, damages and a declaratory judgment. We filed a motion to dismiss Mylan’s complaint on May 25, 2014. Mylan filed its opposition to our motion to dismiss on June 16, 2014. The Federal Trade Commission filed an amicus curiae brief in opposition to our motion to dismiss on June 17, 2014. On December 22, 2014, the court granted our motion to dismiss (i) Mylan’s claims based on Section 1 of the Sherman Act (without prejudice), and (ii) Mylan's related claims arising under the New Jersey Antitrust Act. The court denied our motion to dismiss the remaining claims which primarily relate to Section 2 of the Sherman Act. On January 6, 2015, we filed a motion to certify for interlocutory appeal the order denying our motion to dismiss with respect to the claims relating to Section 2 of the Sherman Act, which appeal was denied by the U.S. Court of Appeals for the Third Circuit on March 5, 2015. On January 20, 2015, we filed an answer to Mylan’s complaint. Fact discovery closed in June 2016 and expert discovery closed in November 2016. On December 16, 2016, we moved for summary judgment, seeking a ruling that judgment be granted in our favor on all claims. The motion for summary judgment was argued on December 13, 2017. Thereafter, the court ordered the parties to mediate and administratively stayed the case pending the mediation. The mediation was held on January 25, 2018, but no settlement was reached. Supplemental briefing on the motion for summary judgment was filed on February 1, 2018. No trial date has been set. THALOMID AND REVLIMID ANTITRUST LITIGATION: On November 7, 2014, the International Union of Bricklayers and Allied Craft Workers Local 1 Health Fund (IUB) filed a putative class action lawsuit against us in the U.S. District Court for the District of New Jersey alleging that we violated various antitrust, consumer protection, and unfair competition laws by (a) allegedly securing an exclusive supply contract with Seratec S.A.R.L. so that Barr Laboratories allegedly could not secure its own supply of thalidomide active pharmaceutical ingredient, (b) allegedly refusing to sell samples of our THALOMID ® and REVLIMID ® brand drugs to various generic manufacturers for the alleged purpose of bioequivalence testing necessary for ANDAs to be submitted to the FDA for approval to market generic versions of these products, and (c) allegedly bringing unjustified patent infringement lawsuits in order to allegedly delay approval for proposed generic versions of THALOMID ® and REVLIMID ® . IUB, on behalf of itself and a putative class of third party payers, is seeking injunctive relief and damages. In February 2015, we filed a motion to dismiss IUB’s complaint, and upon

Nature of Business, Basis of 23

Nature of Business, Basis of Presentation and New Accounting Standards (Policies)	6 Months Ended
	Jun. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
New Accounting Pronouncements	New accounting standards which have not yet been adopted In February 2016, the FASB issued Accounting Standards Update No. 2016-02, "Leases" (ASU 2016-02). ASU 2016-02 provides accounting guidance for both lessee and lessor accounting models. Among other things, lessees will recognize a right-of-use asset and a lease liability for leases with a duration of greater than one year. For income statement purposes, ASU 2016-02 will require leases to be classified as either an operating or finance lease. Operating leases will result in straight-line expense while finance leases will result in a front-loaded expense pattern. The new standard will be effective for us on January 1, 2019 and will be adopted using a modified retrospective approach which will require application of the new guidance at the beginning of the earliest comparative period presented. We are currently evaluating the effect that the updated standard will have on our consolidated financial statements and related disclosures. We expect the implementation of this standard to have an impact on our consolidated financial statements and related disclosures as we had aggregate future minimum lease payments of approximately $235 million as of December 31, 2017 under our portfolio of non-cancelable leased office and research facilities. In addition, Juno had $106 million of aggregate future minimum lease payments as of December 31, 2017. We anticipate recognition of additional assets and corresponding liabilities related to these leases on our consolidated balance sheet. In June 2016, the FASB issued Accounting Standards Update No. 2016-13, "Financial Instruments - Credit Losses: Measurement of Credit Losses on Financial Instruments" (ASU 2016-13). ASU 2016-13 requires that expected credit losses relating to financial assets measured on an amortized cost basis and available-for-sale debt securities be recorded through an allowance for credit losses. ASU 2016-13 limits the amount of credit losses to be recognized for available-for-sale debt securities to the amount by which carrying value exceeds fair value and also requires the reversal of previously recognized credit losses if fair value increases. The new standard will be effective for us on January 1, 2020. Early adoption will be available on January 1, 2019. We are currently evaluating the effect that the updated standard will have on our consolidated financial statements and related disclosures. New accounting standards which have been adopted In May 2014, the FASB issued Accounting Standards Update No. 2014-09, “Revenue from Contracts with Customers” (ASU 2014-09) and has subsequently issued a number of amendments to ASU 2014-09. The new standard, as amended, provides a single comprehensive model to be used in the accounting for revenue arising from contracts with customers and supersedes previous revenue recognition guidance, including industry-specific guidance. The standard’s stated core principle is that an entity should recognize revenue to depict the transfer of promised goods or services to customers in an amount that reflects the consideration to which the entity expects to be entitled in exchange for those goods or services. To achieve this core principle, ASU 2014-09 includes provisions within a five step model that includes identifying the contract with a customer, identifying the performance obligations in the contract, determining the transaction price, allocating the transaction price to the performance obligations, and recognizing revenue when, or as, an entity satisfies a performance obligation. In addition, the standard requires disclosure of the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers. See Note 2 for revenue recognition disclosures. The new standard was effective for us on January 1, 2018 and we elected to adopt it using a modified retrospective transition method, which required a cumulative effect adjustment to opening retained earnings as of January 1, 2018. The implementation of ASU 2014-09 using the modified retrospective transition method did not have a material quantitative impact on our consolidated financial statements as the timing of revenue recognition did not significantly change. We also elected the following practical expedients, which were available to us as a result of utilizing the modified retrospective transition method: • We applied the provisions of the standard only to contracts that were not completed as of January 1, 2018; and • We did not retrospectively restate contracts for contract modifications executed before the beginning of the earliest period presented. In accordance with the transition provisions of ASU 2014-09, we recorded a cumulative effect adjustment of $4 million to increase Retained earnings (net of a $1 million tax effect). In limited instances, the new standard permits us to recognize revenue earlier than under the previous revenue recognition guidance. Historically, we deferred certain revenue where the transaction price pursuant to the underlying customer arrangement was not fixed or determinable. Under the new standard, such customer arrangements are accounted for as variable consideration, which results in revenue being recognized earlier provided we can reliably estimate the ultimate price expected to be realized from the customer. In addition, ASU 2014-09 requires companies who elect to adopt the standard using the modified retrospective transition method to disclose within the footnotes the effects of applying the provisions of the previous standards to current year financial statements. Revenue and net income for the three- and six-month periods ended June 30, 2018, do not differ materially from amounts that would have resulted from application of the previous standards. In January 2016 and February 2018, the FASB issued ASU 2016-01 and Accounting Standards Update No. 2018-03, "Technical Corrections and Improvements to Financial Instruments—Overall: Recognition and Measurement of Financial Assets and Financial Liabilities" (ASU-2018-03), respectively. ASU 2016-01 changes accounting for equity investments, financial liabilities under the fair value option, and presentation and disclosure requirements for financial instruments. ASU 2016-01 does not apply to equity investments in consolidated subsidiaries or those accounted for under the equity method of accounting. In addition, the FASB clarified guidance related to the valuation allowance assessment when recognizing deferred tax assets resulting from unrealized losses on available-for-sale debt securities. Equity investments with readily determinable fair values will be measured at fair value with changes in fair value recognized in net income. We have elected to measure all of our equity investments without readily determinable fair values at cost adjusted for changes in observable prices minus impairment or at net asset value (NAV), as a practical expedient, if available. Changes in measurement of equity investments without readily determinable fair values will be recognized in net income. The guidance related to equity investments without readily determinable fair values, in which the practical expedient has not been elected, will be applied prospectively to equity investments that exist as of the date of adoption. For equity investments without a readily determinable fair value in which the NAV per share practical expedient is elected, ASU 2018-03 clarified that the transition should not be performed prospectively, but rather as a cumulative effect adjustment to opening retained earnings as of the beginning of the fiscal year of adoption. Equity investments without readily determinable fair values are recorded within Other non-current assets on the Consolidated Balance Sheets. We have not elected the fair value option for financial liabilities with instrument-specific credit risk. Companies must assess valuation allowances for deferred tax assets related to available-for-sale debt securities in combination with their other deferred tax assets. ASU 2016-01 was effective for us on January 1, 2018 which required a cumulative effect adjustment to opening retained earnings to be recorded for equity investments with readily determinable fair values and equity investments without readily determinable fair values in which the NAV per share practical expedient was elected. As of the adoption date, we held publicly traded equity investments with a fair value of approximately $1.8 billion in a net unrealized gain position of $875 million , and having an associated deferred tax liability of $188 million . We recorded a cumulative effect adjustment of $687 million to decrease Accumulated other comprehensive income (AOCI) with a corresponding increase to Retained earnings for the amount of unrealized gains or losses, net of tax as of the beginning of fiscal year 2018. In addition, we held an equity investment without a readily determinable fair value in which we elected the NAV per share practical expedient. As such, on January 1, 2018, we recorded an additional cumulative effect adjustment of $59 million to increase Equity investments without readily determinable fair values as the NAV was in excess of our cost basis as of the adoption date with a corresponding increase to Retained earnings of $44 million , net of the tax effect of $15 million . As a result of the implementation of ASU 2016-01, effective on January 1, 2018 unrealized gains and losses in equity investments with readily determinable fair values and equity investments without readily determinable fair values for which observable price changes for identical or similar (e.g. dividend rights, voting rights, etc.) investments occur are recorded on the Consolidated Statement of Income within Other income (expense), net. We recorded a net loss of $6 million and net gain of $953 million in Other income (expense), net for the three- and six-month periods ended June 30, 2018, respectively, as a result of adopting this standard. The implementation of ASU 2016-01 is expected to increase volatility in our net income as the volatility previously recorded in Other comprehensive income (OCI) related to changes in the fair market value of available-for-sale equity investments will now be reflected in net income effective with the adoption date. In February 2018, the FASB issued Accounting Standards Update No. 2018-02, "Income Statement-Reporting Comprehensive Income: Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income" (ASU 2018-02). The new standard is effective on January 1, 2019 with early adoption permitted. The guidance permits a reclassification from AOCI to Retained earnings for stranded tax effects resulting from U.S. tax reform legislation enacted in December 2017 (2017 Tax Act). We elected to early adopt ASU 2018-02 on January 1, 2018. We use a specific identification approach to release the income tax effects in AOCI. We have recast our previously reported Marketable securities available-for-sale on our Consolidated Balance Sheet as of December 31, 2017 to conform to the current year presentation as outlined earlier in this Note 1. As a result of adopting this standard, we recorded a cumulative effect adjustment to increase AOCI by $117 million with a corresponding decrease to Retained earnings. We recorded the impacts of adopting ASU 2018-02 prior to recording the impacts of adopting ASU 2016-01 and included state income tax related effects in the amounts reclassified to Retained earnings. In August 2016, the FASB issued Accounting Standards Update No. 2016-15, "Statement of Cash Flows (Topic 230): Classification of Certain Cash Receipts and Cash Payments" (ASU 2016-15). ASU 2016-15 clarifies how companies present and classify certain cash receipts and cash payments in the statement of cash flows where diversity in practice exists. ASU 2016-15 was effective for us in our first quarter of fiscal 2018 and did not result in any changes to the presentation of our Consolidated Statement of Cash Flows upon adoption. In October 2016, the FASB issued Accounting Standards Update No. 2016-16, "Intra-Entity Transfers of Assets Other Than Inventory” (ASU 2016-16). ASU 2016-16 requires the income tax consequences of intra-entity transfers of assets other than inventory to be recognized as current period income tax expense or benefit and removes the requirement to defer and amortize the consolidated tax consequences of intra-entity transfers. The new standard was effective for us on January 1, 2018. As of the adoption date, we had net prepaid tax assets of $166 million related to intra-entity transfers of assets other than inventory which was recorded in Other non-current assets. Using the modified retrospective approach, we recorded a cumulative effect adjustment of $166 million to decrease Retained earnings with a corresponding decrease in prepaid tax assets as of the beginning of fiscal year 2018. In January 2017, the FASB issued Accounting Standards Update No. 2017-01, “Business Combinations” (ASU 2017-01). ASU 2017-01 provides guidance for evaluating whether transactions should be accounted for as acquisitions (or disposals) of assets or businesses. The guidance provides a screen to determine when an integrated set of assets and activities (a “set”) does not qualify to be a business. The screen requires that when substantially all of the fair value of the gross assets acquired (or disposed of) is concentrated in an identifiable asset or a group of similar identifiable assets, the set is not a business. If the screen is not met, the guidance requires a set to be considered a business to include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create outputs and removes the evaluation as to whether a market participant could replace the missing elements. The new standard was effective for us on January 1, 2018 and was adopted on a prospective basis. In the first quarter of 2018, we acquired Impact Biomedicines Inc. (Impact) and Juno Therapeutics Inc. (Juno) which were accounted for as an asset acquisition and a business combination, respectively.

Nature of Business, Basis of 24

Nature of Business, Basis of Presentation and New Accounting Standards (Tables)	6 Months Ended
	Jun. 30, 2018
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Schedule of New Accounting Pronouncements and Changes in Accounting Principles	The following table presents a summary of cumulative effect adjustments to Retained earnings due to the adoption of new accounting standards on January 1, 2018 as noted above: Cumulative Effect Adjustments to Retained Earnings on January 1, 2018 Increase / (Decrease) Cumulative effect adjustment to Retained earnings due to the adoption of the following new accounting standards: ASU 2014-09 $ 4 ASU 2016-01 687 ASU 2018-03 44 ASU 2018-02 (117 ) ASU 2016-16 (166 ) Net cumulative effect adjustments to Retained earnings on January 1, 2018 due to the adoption of new accounting standards $ 452 As such, we have recast the financial statements for the three- and six-month periods ended June 30, 2017 to reflect the adoption of ASU 2017-12 as follows: Three-Month Period Ended Six-Month Period Ended June 30, 2017 June 30, 2017 As Reported As Revised As Reported As Revised Net product sales $ 3,256 $ 3,259 $ 6,206 $ 6,211 Other (expense) income, net (76 ) (31 ) (50 ) (18 ) Income tax provision 69 77 153 159 Net income 1,061 1,101 2,002 2,033 Diluted net income per common share $ 1.31 $ 1.36 $ 2.47 $ 2.51

Revenue (Tables)

Revenue (Tables)	6 Months Ended
	Jun. 30, 2018
Revenue from Contract with Customer [Abstract]
Reconciliation of Gross Product to Net Product Sales	The reconciliation of gross product sales to net product sales by each significant category of gross-to-net adjustments was as follows: Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Gross Product Sales $ 4,530 $ 3,808 $ 8,777 $ 7,243 Gross-to-Net Adjustments: Government Rebates (269 ) (216 ) (560 ) (434 ) Chargebacks and Distributor Services Fees (390 ) (282 ) (757 ) (508 ) Sales Discounts (59 ) (48 ) (115 ) (90 ) Sales Returns and Allowances (4 ) (3 ) (6 ) — Total Gross-to-Net Adjustments (722 ) (549 ) (1,438 ) (1,032 ) Net Product Sales $ 3,808 $ 3,259 $ 7,339 $ 6,211
Disaggregation of Revenue	Total revenues from external customers by our franchises (Hematology / Oncology and Inflammation & Immunology), product and geography for the three- and six-month periods ended June 30, 2018 and June 30, 2017 were as follows: Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Hematology / Oncology: REVLIMID ® U.S. $ 1,586 $ 1,358 $ 3,073 $ 2,592 International 867 676 1,614 1,326 Worldwide 2,453 2,034 4,687 3,918 POMALYST ® /IMNOVID ® U.S. 341 241 641 457 International 166 150 319 298 Worldwide 507 391 960 755 ABRAXANE ® U.S. 152 161 311 303 International 91 93 194 187 Worldwide 243 254 505 490 VIDAZA ® U.S. 3 2 5 4 International 159 154 314 310 Worldwide 162 156 319 314 All Other U.S. 52 47 107 95 International 16 19 33 39 Worldwide 68 66 140 134 Total Hematology / Oncology: U.S. 2,134 1,809 4,137 3,451 International 1,299 1,092 2,474 2,160 Worldwide $ 3,433 $ 2,901 $ 6,611 $ 5,611 Inflammation & Immunology: OTEZLA ® U.S. $ 291 $ 306 $ 567 $ 505 International 84 52 161 95 Worldwide $ 375 $ 358 $ 728 $ 600 Total net product sales U.S. $ 2,425 $ 2,115 $ 4,704 $ 3,956 International 1,383 1,144 2,635 2,255 Worldwide $ 3,808 $ 3,259 $ 7,339 $ 6,211 Other revenue 6 12 13 22 Total revenue $ 3,814 $ 3,271 $ 7,352 $ 6,233

Acquisitions (Tables)

Acquisitions (Tables)	6 Months Ended
	Jun. 30, 2018
Business Combinations [Abstract]
Schedule of Business Acquisitions, by Acquisition	The total consideration for the acquisition of Juno was $10.4 billion , which consisted of the following: Total Consideration Cash paid for outstanding common stock at $87.00 per share $ 9,101 Celgene investment in Juno at $87.00 per share (1) 966 Cash for equity compensation attributable to pre-combination service (2) 367 Total consideration $ 10,434 (1) The Company recognized a gain of $458 million as a result of remeasuring to fair value the equity interest in Juno held by us before the business combination, which was recorded in Other income (expense), net within the Consolidated Statement of Income during the first quarter of 2018. See Note 1 for further information on the adoption of ASU 2016-01. (2) All equity compensation attributable to pre-combination service was paid
Schedule of Recognized Identified Assets Acquired and Liabilities Assumed	The preliminary purchase price allocation resulted in the following amounts being allocated to the assets acquired and liabilities assumed at the Acquisition Date based upon their respective preliminary fair values summarized below: Amounts Recognized as of the Acquisition Date (Provisional) Working capital (1) $ 437 In-process research and development (IPR&D) 6,980 Technology platform intangible asset 1,260 Property, plant and equipment, net 144 Other non-current assets 46 Deferred tax liabilities, net (1,530 ) Other non-current liabilities (41 ) Total identifiable net assets 7,296 Goodwill 3,138 Total net assets acquired $ 10,434 (1) Includes cash and cash equivalents, debt securities available-for-sale, accounts receivable, other current assets, accounts payable, accrued expenses and other current liabilities (including accrued litigation).
Schedule of Included Business Acquisition Expenses	Juno actual results for the three-months ended June 30, 2018 and from the Acquisition Date through June 30, 2018, which are included in the Consolidated Statement of Income are as follows: Classification in the Consolidated Statements of Income Three-Months Ended June 30, 2018 Acquisition Date Through June 30, 2018 Other revenue $ 1 $ 1 Research and development (1) 225 385 Selling, general and administrative (1) 79 210 Amortization of acquired intangible assets 21 28 Acquisition related charges (income) and restructuring, net (2) 27 49 Interest and investment income, net 3 3 Other income (expense), net 15 11 Income tax provision (benefit), net (63 ) (83 ) Total $ (270 ) $ (574 ) (1) Includes share-based compensation expense related to the post-combination service period of $100 million and $50 million , which was recorded in Research and development and Selling, general and administrative expenses, respectively, for the three-months ended June 30, 2018. Also includes share-based compensation expense related to the post-combination service period of $233 million and $167 million , which was recorded in Research and development and Selling, general and administrative expenses, respectively, for the period from the acquisition date through June 30, 2018. (2) Consists of acquisition related compensation expense, transaction costs and the change in fair value of contingent consideration and success payment liabilities. In addition, Celgene incurred incremental acquisition costs related to Juno of nil and $41 million for the three- and six-month periods ended June 30, 2018 respectively.
Business Acquisition, Pro Forma Information	The following table provides unaudited pro forma financial information for the six-month period ended June 30, 2018 and the three- and six-month periods ended June 30, 2017 as if the acquisition of Juno had occurred on January 1, 2017. Six-Month Periods Ended June 30, Three-Month Period Ended June 30, 2017 2018 2017 Total revenue $ 7,362 $ 6,234 $ 3,272 Net income 1,805 1,495 994 Net income per common share: basic $ 2.47 $ 1.92 $ 1.27 Net income per common share: diluted $ 2.40 $ 1.84 $ 1.22

Earnings Per Share (Tables)

Earnings Per Share (Tables)	6 Months Ended
	Jun. 30, 2018
Earnings Per Share [Abstract]
Schedule of earnings per share	Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, (Amounts in millions, except per share) 2018 2017 2018 2017 Net income $ 1,045 $ 1,101 $ 1,891 $ 2,033 Weighted-average shares: Basic 716.1 780.4 732.1 779.7 Effect of dilutive securities: Options, restricted stock units, performance-based restricted stock units and other 16.5 31.3 18.5 31.8 Diluted 732.6 811.7 750.6 811.5 Net income per share: Basic $ 1.46 $ 1.41 $ 2.58 $ 2.61 Diluted $ 1.43 $ 1.36 $ 2.52 $ 2.51

Accumulated Other Comprehensi28

Accumulated Other Comprehensive Income (Loss) (Tables)	6 Months Ended
	Jun. 30, 2018
Accumulated Other Comprehensive Income (Loss), Net of Tax [Abstract]
Summary of other comprehensive income (loss)	The accumulated balances related to each component of other comprehensive income (loss), net of tax, are summarized as follows: Pension Liability Adjustment Net Unrealized Gains (Losses) On Available-for-Sale Debt Securities / Marketable Securities (1) Net Unrealized Gains (Losses) Related to Cash Flow Hedges Amortization of Excluded Component Related to Cash Flow Hedges (See Note 1) Foreign Currency Translation Adjustments Accumulated Other Comprehensive Income (Loss) Balance as of December 31, 2017 $ (22 ) $ 562 $ (206 ) $ (15 ) $ (32 ) $ 287 Cumulative effect adjustment for the adoption of ASU 2016-01 and ASU 2018-02 (See Note 1) — (566 ) (4 ) — — (570 ) Other comprehensive (loss) income before reclassifications, net of tax — (7 ) 128 (15 ) (12 ) 94 Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax — 14 39 17 — 70 Net current-period other comprehensive income (loss), net of tax — 7 167 2 (12 ) 164 Balance as of June 30, 2018 $ (22 ) $ 3 $ (43 ) $ (13 ) $ (44 ) $ (119 ) Balance as of December 31, 2016 $ (38 ) $ 144 $ 415 $ — $ (102 ) $ 419 Cumulative effect adjustment for the adoption of ASU 2017-12 — — (12 ) (18 ) — (30 ) Other comprehensive income (loss) before reclassifications, net of tax — 148 (259 ) (5 ) 41 (75 ) Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax — 21 (165 ) — — (144 ) Net current-period other comprehensive income (loss), net of tax — 169 (424 ) (5 ) 41 (219 ) Balance as of June 30, 2017 $ (38 ) $ 313 $ (21 ) $ (23 ) $ (61 ) $ 170 (1) Balances as of December 31, 2017 are prior to the adoption of ASU 2016-01 and, as such, include equity securities with readily determinable fair values. Upon adoption of ASU 2016-01, we recorded a cumulative effect adjustment for our net unrealized gains related to our equity securities with readily determinable fair values as of January 1, 2018. Therefore, the unrealized gains (losses) position as of June 30, 2018 solely relate to debt securities available-for-sale. See Note 1 for further information related to the adoption of ASU 2016-01.
Schedule of gains (losses) reclassified out of accumulated other comprehensive income	Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income Accumulated Other Comprehensive Income (Loss) Components Classification in the Consolidated Statements of Income Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 (Losses) gains related to cash-flow hedges: Foreign exchange contracts Net product sales $ (12 ) $ 81 $ (38 ) $ 167 Treasury rate lock agreements Interest (expense) (1 ) (2 ) (2 ) (3 ) Interest rate swap agreements Interest (expense) — — — (1 ) Income tax provision - (expense) benefit 1 1 1 2 Excluded component related to cash-flow hedges: Foreign exchange contracts Net product sales 1 3 (2 ) 5 (Losses) gains on available-for-sale debt securities / marketable securities (1) : Realized (loss) gain on sales of debt securities / marketable securities Interest and investment income, net — (34 ) (18 ) (34 ) Income tax provision - (expense) benefit — 13 4 13 Total reclassification, net of tax $ (11 ) $ 62 $ (55 ) $ 149 (1) (Losses) gains reclassified out of Accumulated other comprehensive income prior to December 31, 2017 are prior to the adoption of ASU 2016-01 and, as such, include equity securities with readily determinable fair values. Upon adoption of ASU 2016-01, we recorded a cumulative effect adjustment for our net unrealized gains related to our equity securities with readily determinable fair values as of January 1, 2018. Therefore, unrealized gains (losses) for the three- and six-month periods ended June 30, 2018 solely relate to debt securities available-for-sale. See Note 1 for further information related to the adoption of ASU 2016-01.

Financial Instruments and Fai29

Financial Instruments and Fair Value Measurement (Tables)	6 Months Ended
	Jun. 30, 2018
Fair Value Disclosures [Abstract]
Schedule of Significant Unobservable Inputs Calculation	The fair value of our contingent consideration as of June 30, 2018 and December 31, 2017 was calculated using the following significant unobservable inputs: Inputs Ranges (weighted average) utilized as of: June 30, 2018 December 31, 2017 Discount rate 2.5% to 4.0% (3.2%) 2.7% to 12.0% (3.5%) Probability of payment 0% to 68% (4.6%) 0% to 20% (4%) Projected year of payment for development and regulatory milestones 2020 to 2029 (2023) 2020 to 2029 (2024) Projected year of payment for sales-based milestones and other amounts calculated as a percentage of annual sales N/A 2024 to 2030 (2028)
Assets and liabilities measured at fair value on recurring basis	Fair Value Measurements as of June 30, 2018 Balance as of June 30, 2018 Quoted Price in Active Markets for Identical Assets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) Assets: Debt securities available-for-sale $ 79 $ — $ 79 $ — Equity investments with readily determinable fair values 1,828 1,828 — — Forward currency contracts 27 — 27 — Purchased currency options 33 — 33 — Total assets $ 1,967 $ 1,828 $ 139 $ — Liabilities: Contingent value rights $ (18 ) $ (18 ) $ — $ — Interest rate swaps (27 ) — (27 ) — Written currency options (81 ) — (81 ) — Other acquisition related contingent consideration and success payments (193 ) — — (193 ) Total liabilities $ (319 ) $ (18 ) $ (108 ) $ (193 )
Schedule of Remeasurement of Equity Investments	The following table represents a roll-forward of equity investments without readily determinable fair values: Six-Month Period Ended June 30, 2018 Balance as of December 31, 2017 $ 513 Cumulative effect adjustment for the adoption of ASU 2018-03 (See Note 1) 59 Purchases 46 Upward adjustments 32 Sales (23 ) Downward adjustments (1 ) Impairments (1 ) Transfer to readily determinable fair value (20 ) Balance as of June 30, 2018 $ 605
Roll-forward of fair value of Level 3 instruments (significant unobservable inputs), liabilities	The following table represents a roll-forward of the fair value of level 3 instruments: Three-Month Period Ended June 30, 2018 Liabilities: Balance as of March 31, 2018 $ (201 ) Amounts acquired from Juno, including measurement period adjustments 6 Settlements, including transfers to Accrued expenses and other current liabilities 2 Balance as of June 30, 2018 $ (193 ) Three-Month Period Ended June 30, 2017 Liabilities: Balance as of March 31, 2017 $ (1,527 ) Net change in fair value 20 Settlements, including transfers to Accrued expenses and other current liabilities 19 Balance as of June 30, 2017 $ (1,488 ) There were no security transfers between levels 1, 2 and 3 during the six-month periods ended June 30, 2018 and 2017 . The following table represents a roll-forward of the fair value of level 3 instruments: Six-Month Period Ended June 30, 2018 Liabilities: Balance as of December 31, 2017 $ (80 ) Amounts acquired from Juno, including measurement period adjustments (116 ) Net change in fair value 1 Settlements, including transfers to Accrued expenses and other current liabilities 2 Balance as of June 30, 2018 $ (193 ) Six-Month Period Ended June 30, 2017 Liabilities: Balance as of December 31, 2016 $ (1,490 ) Net change in fair value (17 ) Settlements, including transfers to Accrued expenses and other current liabilities 19 Balance as of June 30, 2017 $ (1,488 )

Derivative Instruments and He30

Derivative Instruments and Hedging Activities (Tables)	6 Months Ended
	Jun. 30, 2018
Derivative Instruments and Hedging Activities Disclosure [Abstract]
Schedule of notional amount of derivative contracts	The following table summarizes the notional amounts of our outstanding interest rate swap contracts as of June 30, 2018 and December 31, 2017: Notional Amount June 30, 2018 December 31, 2017 Interest rate swap contracts entered into as fair value hedges of the following fixed-rate senior notes: 3.875% senior notes due 2025 $ 200 $ 200 3.450% senior notes due 2027 550 250 3.900% senior notes due 2028 200 — Total $ 950 $ 450 Foreign currency forward contracts entered into to hedge forecasted revenue and expenses were as follows as of June 30, 2018 and December 31, 2017 : Notional Amount Foreign Currency June 30, 2018 December 31, 2017 Australian Dollar $ 46 $ 61 British Pound 134 97 Canadian Dollar 190 227 Euro 962 954 Japanese Yen 508 356 Total $ 1,840 $ 1,695
Schedule of foreign exchange contracts, statement of financial position	Outstanding foreign currency option contracts entered into to hedge forecasted revenue were as follows as of June 30, 2018 and December 31, 2017 : Notional Amount (1) June 30, 2018 December 31, 2017 Foreign currency option contracts designated as hedging activity: Purchased Put $ 2,756 $ 3,319 Written Call 3,131 3,739 (1) U.S. Dollar notional amounts are calculated as the hedged local currency amount multiplied by the strike value of the foreign currency option. The local currency notional amounts of our purchased put and written call that are designated as hedging activities are equal to each other.
Schedule of derivative instruments in statement of financial position	The following tables summarize the fair value and presentation in the Consolidated Balance Sheets for derivative instruments as of June 30, 2018 and December 31, 2017 : June 30, 2018 Balance Sheet Location Fair Value Instrument Asset Derivatives Liability Derivatives Derivatives designated as hedging instruments: Foreign exchange contracts (1) Other current assets $ 56 $ 29 Accrued expenses and other current liabilities 4 10 Other non-current assets 4 — Other non-current liabilities 34 68 Interest rate swap agreements Other current assets 7 — Other non-current liabilities — 36 Derivatives not designated as hedging instruments: Foreign exchange contracts (1) Other current assets 25 3 Accrued expenses and other current liabilities 3 37 Interest rate swap agreements Other current assets 2 1 Other non-current assets 7 6 Total $ 142 $ 190 (1) Derivative instruments in this category are subject to master netting arrangements and are presented on a net basis in the Consolidated Balance Sheet in accordance with ASC 210-20. December 31, 2017 Fair Value Instrument Balance Sheet Location Asset Derivatives Liability Derivatives Derivatives designated as hedging instruments: Foreign exchange contracts (1) Other current assets $ 5 $ 1 Accrued expenses and other current liabilities 30 79 Other non-current assets 1 — Other non-current liabilities 36 159 Interest rate swap agreements Other current assets 3 — Other non-current liabilities — 11 Derivatives not designated as hedging instruments: Foreign exchange contracts (1) Other current assets 8 1 Accrued expenses and other current liabilities 4 22 Interest rate swap agreements Other current assets 2 2 Other non-current assets 4 3 Total $ 93 $ 278 (1) Derivative instruments in this category are subject to master netting arrangements and are presented on a net basis in the Consolidated Balance Sheet in accordance with ASC 210-20.
Cumulative basis adjustments for fair value hedges	As of June 30, 2018 and December 31, 2017, the following amounts were recorded on the Consolidated Balance Sheet related to cumulative basis adjustments for fair value hedges: Carrying Amount of the Hedged Liability Cumulative Amount of Fair Value Hedging Adjustment Included in the Carrying Amount of the Hedged Liability Consolidated Balance Sheet Classification in Which the Hedged Item Is Included June 30, 2018 (1) December 31, 2017 (1) June 30, 2018 (2) December 31, 2017 (2) Current portion of long-term debt, net of discount $ 503 $ — $ 4 $ — Long-term debt, net of discount 8,173 7,270 84 128 (1) The current portion of long-term debt, net of discount includes approximately $503 million of carrying value with discontinued hedging relationships at June 30, 2018. The long-term debt, net of discount includes approximately $3.2 billion and $3.8 billion of carrying value with discontinued hedging relationships as of June 30, 2018 and December 31, 2017, respectively. (2) The current portion of long-term debt, net of discount includes $4 million of discontinued hedging relationships at June 30, 2018. The long-term debt, net of discount includes $120 million and $139 million of hedging adjustment on discontinued hedging relationships on long-term debt as of June 30, 2018 and December 31, 2017, respectively.
Schedule of effect of derivative instruments designated as hedging instruments on Consolidated Statements of Income	uring the three- and six-month periods ended June 30, 2018 and 2017, there were no gains or losses from the sale of put options. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Three-Month Period Ended June 30, 2018 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 3,808 $ (192 ) $ 4 The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — 11 — Derivatives designated as hedging instruments (1) — (2 ) — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income (12 ) — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 7 — — Reclassification adjustment for excluded component (loss) gain (6 ) Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (1 ) — (1) The amounts include a benefit of $8 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the three-month period ending June 30, 2018. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Three-Month Period Ended June 30, 2017 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 3,259 $ (126 ) $ (31 ) The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — (2 ) — Derivatives designated as hedging instruments (1) — 11 — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income 81 — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 3 — 1 Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (2 ) — (1) The amounts include a benefit of $9 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the three-month period ending June 30, 2017. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Six-Month Period Ended June 30, 2018 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 7,339 $ (358 ) $ 969 The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — 25 — Derivatives designated as hedging instruments (1) — (7 ) — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income (38 ) — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 15 — — Reclassification adjustment for excluded component (loss) gain (17 ) — — Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (2 ) — (1) The amounts include a benefit of $16 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the six-month period ending June 30, 2018. Classification and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships Six-Month Period Ended June 30, 2017 Net product sales Interest (expense) Other income (expense), net Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded $ 6,211 $ (253 ) $ (18 ) The effects of fair value and cash flow hedging: Gain (loss) on fair value hedging relationships Interest rate swap agreements: Hedged items — (1 ) — Derivatives designated as hedging instruments (1) — 20 — Gain (loss) on cash flow hedging relationships Foreign exchange contracts: Amount of gain or (loss) reclassified from AOCI into income 167 — — Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value 5 — 8 Treasury rate lock agreements: Amount of gain or (loss) reclassified from AOCI into income — (3 ) — Interest rate swap agreements: Amount of gain or (loss) reclassified from AOCI into income — (1 ) — (1) The amounts include a benefit of $18 million relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships for the six-month period ending June 30, 2017. The following tables summarize the effect of derivative instruments designated as cash flow hedging instruments in Accumulated OCI for the three-month periods ended June 30, 2018 and 2017 : Three-Month Period Ended June 30, 2018 Instrument Amount of (1), (2) Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ 226 Net product sales $ (12 ) Net product sales $ 1 Treasury rate lock agreements — Interest (expense) (1 ) N/A — (1) Net losses of $7 million are expected to be reclassified from Accumulated OCI into income in the next 12 months. (2) For the three-month period ended June 30, 2018, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a gain of $1 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. Three-Month Period Ended June 30, 2017 Instrument Amount of Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ (181 ) Net product sales $ 81 Net product sales $ 3 Other income (expense), net 1 Treasury rate lock agreements — Interest (expense) (2 ) N/A — Forward starting interest rate swaps (17 ) Interest (expense) — N/A — The following tables summarize the effect of derivative instruments designated as cash flow hedging instruments in Accumulated OCI for the six-month periods ended June 30, 2018 and 2017 : Six-Month Period Ended June 30, 2018 Instrument Amount of (1), (2) Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ 131 Net product sales $ (38 ) Net product sales $ (2 ) Treasury rate lock agreements (4 ) Interest (expense) (2 ) Other income (expense), net — (1) Net losses of $7 million are expected to be reclassified from Accumulated OCI into income in the next 12 months. (2) For the six-month period ended June 30, 2018, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a loss of $2 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. Six-Month Period Ended June 30, 2017 Instrument Amount of Classification of Amount of Classification of Gain/(Loss) Recognized in Income Related to Amount Excluded from Effectiveness Testing Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing Foreign exchange contracts $ (249 ) Net product sales $ 167 Net product sales $ 5 Other income (expense), net 8 Treasury rate lock agreements — Interest (expense) (3 ) N/A — Forward starting interest rate swaps (17 ) Interest (expense) (1 ) N/A — (1) For the six-month period ended June 30, 2017, the straight-line amortization of the initial value of the amount excluded from the assessment of hedge effectiveness for our foreign exchange contracts recognized in OCI was a gain of $5 million . There were no excluded components for our treasury rate lock and interest rate swap agreements. The following table summarizes the effect of derivative instruments which were designated as fair value hedging instruments on the Consolidated Statements of Income for the three-month periods ended June 30, 2018 and 2017 : Amount of (Loss)/Gain Recognized in Income on Derivative Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, Instrument Classification of (Loss)/Gain Recognized in Income on Derivative 2018 (1) 2017 (1) 2018 (1) 2017 (1) Interest rate swap agreements Interest (expense) $ (2 ) $ 11 $ (7 ) $ 20 (1) The amounts include a benefit of $8 million and $9 million for the three-month periods ending June 30, 2018 and 2017, respectively and a benefit of $16 million and $18 million for the six-months periods ending June 30, 2018 and 2017, respectively, relating to the amortization of the cumulative amount of fair value hedging adjustments included in the carrying amount of the hedged liability for discontinued hedging relationships. The following table summarizes the effect of derivative instruments not designated as hedging instruments on the Consolidated Statements of Income for the three- and six-month periods ended June 30, 2018 and 2017 : Classification of Gain (Loss) Recognized in Income on Derivative Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, Instrument Classification of Gain (Loss) Recognized in Income on Derivative 2018 2017 2018 2017 Foreign exchange contracts Other income (expense), net $ 22 $ (19 ) $ 9 $ (42 )

Cash, Cash Equivalents, Debt 31

Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values (Tables)	6 Months Ended
	Jun. 30, 2018
Cash, Cash Equivalents, and Short-term Investments [Abstract]
Schedule of available-for-sale securities by major security type and class	The amortized cost, gross unrealized holding gains, gross unrealized holding losses and estimated fair value of debt securities available-for-sale by major security type and class of security and equity investments with readily determinable fair values as of June 30, 2018 and December 31, 2017 were as follows: June 30, 2018 Amortized Cost Gross Unrealized Gain Gross Unrealized Loss Estimated Fair Value Time deposits (1) and Repurchase agreements (1) $ 79 $ — $ — $ 79 Total debt securities available-for-sale $ 79 $ — $ — $ 79 December 31, 2017 Amortized Cost Gross Unrealized Gain Gross Unrealized Loss Estimated Fair Value U.S. Treasury securities $ 445 $ — $ (3 ) $ 442 U.S. government-sponsored agency securities 42 — — 42 U.S. government-sponsored agency MBS 17 — — 17 Corporate debt - global 2,080 — (5 ) 2,075 Asset backed securities 203 — (1 ) 202 Ultra short income fund 352 — — 352 Time deposits (1) and Repurchase agreements (1) 89 — — 89 Total debt securities available-for-sale $ 3,228 $ — $ (9 ) $ 3,219 Equity securities with readily determinable fair values $ 935 $ 881 $ (6 ) $ 1,810 (1) Have original maturities of greater than three months.
Schedule of duration periods of available-for-sale debt securities	Duration periods of available-for-sale debt securities as of June 30, 2018 were as follows: Amortized Cost Fair Value Duration of one year or less $ 79 $ 79

Inventory (Tables)

Inventory (Tables)	6 Months Ended
	Jun. 30, 2018
Inventory Disclosure [Abstract]
Summary of inventories by major category	Inventories as of June 30, 2018 and December 31, 2017 are summarized by major category as follows: June 30, 2018 December 31, 2017 Raw materials $ 344 $ 289 Work in process 68 89 Finished goods 143 163 Total $ 555 $ 541

Intangible Assets and Goodwill

Intangible Assets and Goodwill (Tables)	6 Months Ended
	Jun. 30, 2018
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of finite-live intangible assets	The gross carrying amount and accumulated amortization of intangible assets as of June 30, 2018 and December 31, 2017 are summarized as follows: June 30, 2018 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (2,087 ) $ 1,319 Technology 1,743 (474 ) 1,269 Licenses 66 (32 ) 34 Other 54 (37 ) 17 5,269 (2,630 ) 2,639 Non-amortizable intangible assets: Acquired IPR&D product rights 13,831 — 13,831 Total intangible assets $ 19,100 $ (2,630 ) $ 16,470 December 31, 2017 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (1,939 ) $ 1,467 Technology 483 (410 ) 73 Licenses 66 (30 ) 36 Other 43 (34 ) 9 3,998 (2,413 ) 1,585 Non-amortizable intangible assets: Acquired IPR&D product rights 6,851 — 6,851 Total intangible assets $ 10,849 $ (2,413 ) $ 8,436
Schedule of indefinite-live intangible assets	The gross carrying amount and accumulated amortization of intangible assets as of June 30, 2018 and December 31, 2017 are summarized as follows: June 30, 2018 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (2,087 ) $ 1,319 Technology 1,743 (474 ) 1,269 Licenses 66 (32 ) 34 Other 54 (37 ) 17 5,269 (2,630 ) 2,639 Non-amortizable intangible assets: Acquired IPR&D product rights 13,831 — 13,831 Total intangible assets $ 19,100 $ (2,630 ) $ 16,470 December 31, 2017 Gross Carrying Value Accumulated Amortization Intangible Assets, Net Amortizable intangible assets: Acquired developed product rights $ 3,406 $ (1,939 ) $ 1,467 Technology 483 (410 ) 73 Licenses 66 (30 ) 36 Other 43 (34 ) 9 3,998 (2,413 ) 1,585 Non-amortizable intangible assets: Acquired IPR&D product rights 6,851 — 6,851 Total intangible assets $ 10,849 $ (2,413 ) $ 8,436

Debt (Tables)

Debt (Tables)	6 Months Ended
	Jun. 30, 2018
Debt Disclosure [Abstract]
Schedule of Short-term Debt	The carrying value of short-term borrowings and current portion of long-term debt as of June 30, 2018 and December 31, 2017 includes: June 30, 2018 December 31, 2017 Commercial paper $ 995 $ — 2.250% senior notes due 2019 502 — Total short-term borrowings and current portion of long-term debt $ 1,497 $ —
Carrying values of the senior notes	The carrying values of the long-term portion of these senior notes as of June 30, 2018 and December 31, 2017 includes: June 30, 2018 December 31, 2017 2.250% senior notes due 2019 $ — $ 505 2.875% senior notes due 2020 1,496 1,495 3.950% senior notes due 2020 511 514 2.250% senior notes due 2021 497 497 2.875% senior notes due 2021 498 — 3.250% senior notes due 2022 1,039 1,044 3.550% senior notes due 2022 995 994 2.750% senior notes due 2023 746 746 3.250% senior notes due 2023 993 — 4.000% senior notes due 2023 734 737 3.625% senior notes due 2024 1,001 1,001 3.875% senior notes due 2025 2,472 2,478 3.450% senior notes due 2027 974 991 3.900% senior notes due 2028 1,486 — 5.700% senior notes due 2040 247 247 5.250% senior notes due 2043 393 393 4.625% senior notes due 2044 987 987 5.000% senior notes due 2045 1,975 1,975 4.350% senior notes due 2047 1,234 1,234 4.550% senior notes due 2048 1,476 — Total long-term debt $ 19,754 $ 15,838

Share-Based Compensation (Table

Share-Based Compensation (Tables)	6 Months Ended
	Jun. 30, 2018
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Components of share-based compensation expense	The following table summarizes the components of share-based compensation expense in the Consolidated Statements of Income for the three- and six-month periods ended June 30, 2018 and 2017 : Three-Month Periods Ended June 30, Six-Month Periods Ended June 30, 2018 2017 2018 2017 Cost of goods sold (excluding amortization of acquired intangible assets) $ 9 $ 8 $ 18 $ 15 Research and development (1) 157 70 356 135 Selling, general and administrative (2) 118 92 311 173 Total share-based compensation expense 284 170 685 323 Tax benefit related to share-based compensation expense 37 46 74 87 Reduction in net income $ 247 $ 124 $ 611 $ 236 (1) The three- and six-month periods ended June 30, 2018 include Juno related share-based compensation expense related to the post-combination service period of $100 million and $233 million , respectively.
Summary of activity for stock options, RSUs and PSUs	The following table summarizes the activity for stock options, RSUs and PSUs for the six-month period ended June 30, 2018 (in millions unless otherwise noted): Stock Options RSUs PSUs (in thousands) Outstanding as of December 31, 2017 67.8 7.7 558 Changes during the Year: Conversion of Juno awards 3.7 2.5 336 Granted 6.8 3.4 162 Exercised / Released (3.5 ) (2.1 ) (247 ) Forfeited (1.8 ) (0.4 ) (28 ) Outstanding as of June 30, 2018 73.0 11.1 781
Schedule of unvested awards compensation cost not yet recognized and weighted-average periods for recognition	Total compensation cost related to unvested awards not yet recognized and the weighted-average periods over which the awards are expected to be recognized as of June 30, 2018 were as follows (dollars in millions): Stock Options RSUs PSUs Unrecognized compensation cost $ 641 $ 566 $ 43 Expected weighted-average period in years of compensation cost to be recognized 2.2 1.9 1.5

Collaboration Agreements (Table

Collaboration Agreements (Tables)	6 Months Ended
	Jun. 30, 2018
Collaboration Agreements [Abstract]
Schedule of Collaboration Agreements	A financial summary of certain period activity and the period-end balances related to Vividion is presented below (1) : Six-Month Period Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 97 $ — $ — $ — $ 4 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ — $ 4 5.8 % (1) There was no collaboration activity related to Vividion during the three-month period ended June 30, 2018. In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us. A financial summary of certain period activity and the period-end balances related to our other collaboration arrangements is presented below (1) : Three-Month Periods Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 146 $ 15 $ 4 $ 2 $ 20 2017 75 — — 3 67 Six-Month Periods Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 184 $ 15 $ 4 $ 4 $ 77 2017 85 — 7 7 79 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ 7 $ 1,710 N/A December 31, 2017 12 1,806 N/A (1) In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us. A financial summary of certain period activity and the period-end balances related to Prothena is presented below (1) : Six-Month Period Ended June 30, Research and Development Expense Upfront Fees Milestones Extension/Termination of Arrangements Amortization of Prepaid Research and Development Equity Investments Made During Period 2018 $ 110 $ — $ — $ — $ 40 Balances as of: Intangible Asset Balance Equity Investment Balance Percentage of Outstanding Equity June 30, 2018 $ — $ 17 2.9 % (1) There was no collaboration activity related to Prothena during the three-month period ended June 30, 2018. In addition to the expenses noted in the table above, we may also incur expenses for collaboration agreement related activities that are managed or funded by us.

Nature of Business, Basis of 37

Nature of Business, Basis of Presentation and New Accounting Standards (Narrative) (Details)	6 Months Ended
	Jun. 30, 2018
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Maximum equity ownership percentage, investments	50.00%

Nature of Business, Basis of 38

Nature of Business, Basis of Presentation and New Accounting Standards (Equity Investments, ASU 2016-01) (Details) - USD ($)	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt securities available-for-sale	$ 79,000,000		$ 3,219,000,000
Equity investments with readily determinable fair values	1,828,000,000		1,810,000,000
Purchases of equity investment securities	(155,000,000)	$ (156,000,000)
Purchases of debt securities available-for-sale		(3,411,000,000)
Proceeds from sales of debt securities available-for-sale	3,240,000,000	2,057,000,000
Proceeds from sales of equity investment securities	$ 55,000,000	27,000,000
As Reported
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Marketable securities available-for-sale			$ 5,029,000,000
Purchases of marketable securities available-for-sale		(3,482,000,000)
Purchases of equity investment securities		(85,000,000)
Proceeds from sales of marketable securities available-for-sale		$ 2,070

Nature of Business, Basis of 39

Nature of Business, Basis of Presentation and New Accounting Standards (ASU 2017-12) (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended			6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Mar. 31, 2017	Jun. 30, 2018	Jun. 30, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Income before income taxes	$ 1,307	$ 1,178		$ 2,337	$ 2,192
Net product sales	3,814	3,271		7,352	6,233
Other (expense) income, net	4	(31)		969	(18)
Income tax provision	262	77		446	159
Net income	$ 1,045	$ 1,101		$ 1,891	$ 2,033
Diluted net income per common share (in dollars per share)	$ 1.43	$ 1.36		$ 2.52	$ 2.51
As Reported
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Other (expense) income, net			$ (76)		$ (50)
Income tax provision			69		153
Net income			$ 1,061		$ 2,002
Diluted net income per common share (in dollars per share)			$ 1.31		$ 2.47
Accounting Standards Update 2017-12
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Income before income taxes		$ 48			$ 37
Other (expense) income, net			$ (31)		(18)
Income tax provision			77		159
Net income			$ 1,101		$ 2,033
Diluted net income per common share (in dollars per share)			$ 1.36		$ 2.51
Net product sales
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net product sales	$ 3,808	$ 3,259		$ 7,339	$ 6,211
Net product sales | As Reported
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net product sales			$ 3,256		6,206
Net product sales | Accounting Standards Update 2017-12
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Net product sales			$ 3,259		$ 6,211

Nature of Business, Basis of 40

Nature of Business, Basis of Presentation and New Accounting Standards (Newly adopted standards) (Details) - USD ($) $ in Millions	Jan. 01, 2018	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	$ 452
Other income (expense), net		$ 4	$ (31)	$ 969	$ (18)
Equity investments with readily determinable fair values	1,800	1,828		1,828		$ 1,810
Marketable securities unrealized gain	875
Deferred tax liability	188
ASU 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	4
Tax effect of new accounting principle	1
ASU 2014-09 | Net product sales
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(4)
ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	687
ASU 2018-02
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(117)
ASU 2016-16
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(166)
Deferred tax asset, intra-entity transfer, asset other than inventory						166
AOCI Including Portion Attributable to Noncontrolling Interest | ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(687)
AOCI Including Portion Attributable to Noncontrolling Interest | ASU 2018-02
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	117
Retained Earnings | ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	687
Retained Earnings | ASU 2018-02
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(117)
Retained Earnings | ASU 2016-16
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment						$ (166)
Investment Without Determinable Fair Values | Retained Earnings | ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	59
Investments | ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Other income (expense), net		$ (6)		$ 953
Investments | Retained Earnings | ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	44
Tax effect of new accounting principle	$ 15

Nature of Business, Basis of 41

Nature of Business, Basis of Presentation and New Accounting Standards (Cumulative Effect Adjustments) (Details) $ in Millions	Jan. 01, 2018USD ($)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	$ 452
ASU 2014-09
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	4
ASU 2016-01
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	687
ASU 2018-03
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	44
ASU 2018-02
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	(117)
ASU 2016-16
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment	$ (166)

Nature of Business, Basis of 42

Nature of Business, Basis of Presentation and New Accounting Standards (Not yet adopted) (Details) $ in Millions	Dec. 31, 2017USD ($)
Business Acquisition [Line Items]
Operating leases, future minimum payments due	$ 235
Juno
Business Acquisition [Line Items]
Operating leases, future minimum payments due	$ 106

Revenue (Gross Product Sales to

Revenue (Gross Product Sales to Net Product Sales Reconciliation) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Disaggregation of Revenue [Line Items]
Total revenue	$ 3,814	$ 3,271	$ 7,352	$ 6,233
Gross to Net Sales Adjustments	(722)	(549)	(1,438)	(1,032)
Government Rebates
Disaggregation of Revenue [Line Items]
Gross to Net Sales Adjustments	(269)	(216)	560	434
Chargebacks and Distributor Services Fees
Disaggregation of Revenue [Line Items]
Gross to Net Sales Adjustments	(390)	(282)	757	508
Sales Discounts
Disaggregation of Revenue [Line Items]
Gross to Net Sales Adjustments	(59)	(48)	115	90
Sales Returns and Allowances
Disaggregation of Revenue [Line Items]
Gross to Net Sales Adjustments	(4)	(3)	6	0
Gross Product Sales
Disaggregation of Revenue [Line Items]
Total revenue	4,530	3,808	8,777	7,243
Net product sales
Disaggregation of Revenue [Line Items]
Total revenue	$ 3,808	$ 3,259	$ 7,339	$ 6,211

Revenue (Details)

Revenue (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Disaggregation of Revenue [Line Items]
Total revenue	$ 3,814	$ 3,271	$ 7,352	$ 6,233
Hematology / Oncology:
Disaggregation of Revenue [Line Items]
Total revenue	3,433	2,901	6,611	5,611
Hematology / Oncology: | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	2,134	1,809	4,137	3,451
Hematology / Oncology: | International
Disaggregation of Revenue [Line Items]
Total revenue	1,299	1,092	2,474	2,160
Hematology / Oncology: | Revlimid
Disaggregation of Revenue [Line Items]
Total revenue	2,453	2,034	4,687	3,918
Hematology / Oncology: | Revlimid | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	1,586	1,358	3,073	2,592
Hematology / Oncology: | Revlimid | International
Disaggregation of Revenue [Line Items]
Total revenue	867	676	1,614	1,326
Hematology / Oncology: | Pomalyst/Imnovid
Disaggregation of Revenue [Line Items]
Total revenue	507	391	960	755
Hematology / Oncology: | Pomalyst/Imnovid | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	341	241	641	457
Hematology / Oncology: | Pomalyst/Imnovid | International
Disaggregation of Revenue [Line Items]
Total revenue	166	150	319	298
Hematology / Oncology: | Abraxane
Disaggregation of Revenue [Line Items]
Total revenue	243	254	505	490
Hematology / Oncology: | Abraxane | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	152	161	311	303
Hematology / Oncology: | Abraxane | International
Disaggregation of Revenue [Line Items]
Total revenue	91	93	194	187
Hematology / Oncology: | Vidaza
Disaggregation of Revenue [Line Items]
Total revenue	162	156	319	314
Hematology / Oncology: | Vidaza | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	3	2	5	4
Hematology / Oncology: | Vidaza | International
Disaggregation of Revenue [Line Items]
Total revenue	159	154	314	310
Hematology / Oncology: | All Other Hematology and Oncology
Disaggregation of Revenue [Line Items]
Total revenue	68	66	140	134
Hematology / Oncology: | All Other Hematology and Oncology | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	52	47	107	95
Hematology / Oncology: | All Other Hematology and Oncology | International
Disaggregation of Revenue [Line Items]
Total revenue	16	19	33	39
Inflammation & Immunology: | Otezla
Disaggregation of Revenue [Line Items]
Total revenue	375	358	728	600
Inflammation & Immunology: | Otezla | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	291	306	567	505
Inflammation & Immunology: | Otezla | International
Disaggregation of Revenue [Line Items]
Total revenue	84	52	161	95
Net product sales
Disaggregation of Revenue [Line Items]
Total revenue	3,808	3,259	7,339	6,211
Net product sales | U.S.
Disaggregation of Revenue [Line Items]
Total revenue	2,425	2,115	4,704	3,956
Net product sales | International
Disaggregation of Revenue [Line Items]
Total revenue	1,383	1,144	2,635	2,255
Other revenue
Disaggregation of Revenue [Line Items]
Total revenue	$ 6	$ 12	$ 13	$ 22

Revenue (Narrative) (Details)

Revenue (Narrative) (Details) $ in Millions	3 Months Ended	6 Months Ended
	Jun. 30, 2018USD ($)	Jun. 30, 2018USD ($)
Revenue from Contract with Customer [Abstract]
Contract with customer asset	$ 25	$ 25
Contract with customer asset	5	28
Contract with customer liability revenue recognized	82	98
Contract with customer, liability	$ 127	$ 127

Acquisitions (Impact Biomedicin

Acquisitions (Impact Biomedicines) (Details) - Impact Biomedicines Inc $ in Millions	Feb. 12, 2018USD ($)
Business Acquisition [Line Items]
Payments to acquire assets	$ 1,100
Contingent regulatory milestones eligibility	1,400
Potential milestone payment	4,500
Net assets acquired	7
Minimum
Business Acquisition [Line Items]
Revenues	1,000
Maximum
Business Acquisition [Line Items]
Revenues	$ 5,000

Acquisitions (Juno Therapeutics

Acquisitions (Juno Therapeutics - Narrative) (Details) - USD ($) $ in Millions	Mar. 06, 2018	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Business Acquisition [Line Items]
Allocated compensation expense		$ 284	$ 170	$ 685	$ 323
Juno
Business Acquisition [Line Items]
Consideration transferred	$ 10,434
Cash paid for outstanding common stock	9,101
Equity compensation attributable to the pre-combination service period	367
Celgene investment in Juno, fair value	$ 966
Cash for the portion of equity compensation attributable to the post-combination service period				666
Allocated compensation expense		$ 150		$ 400

Acquisitions (Juno) (Details)

Acquisitions (Juno) (Details) - USD ($) $ / shares in Units, $ in Millions	Mar. 06, 2018	Mar. 31, 2018	Jun. 30, 2018	Dec. 31, 2017
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net [Abstract]
Goodwill			$ 8,004	$ 4,866
Juno
Business Combination, Consideration Transferred
Cash paid for outstanding common stock	$ 9,101
Celgene investment in Juno at $87.00 per share	966
Cash for equity compensation attributable to pre-combination service	367
Total consideration	$ 10,434
Gain recognized based on fair market value of equity interest		$ 458
Investment owned (usd per share)	$ 87
Business Combination, Recognized Identifiable Assets Acquired and Liabilities Assumed, Net [Abstract]
Working capital	$ 437
In-process research and development (IPR&D)	6,980
Technology platform intangible asset	1,260
Property, plant and equipment	144
Other non-current assets	46
Deferred tax liabilities, net	(1,530)
Other non-current liabilities	(41)
Total identifiable net assets	7,296
Goodwill	3,138
Total net assets acquired	$ 10,434

Acquisitions (Juno - Income Sta

Acquisitions (Juno - Income Statement Location) (Details) - USD ($)	3 Months Ended		4 Months Ended	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2018	Jun. 30, 2017
Business Acquisition [Line Items]
Allocated compensation expense	$ 284,000,000	$ 170,000,000		$ 685,000,000	$ 323,000,000
Acquisition related charges (income) and restructuring, net	34,000,000	(13,000,000)		65,000,000	26,000,000
Research and development
Business Acquisition [Line Items]
Allocated compensation expense	157,000,000	70,000,000		356,000,000	135,000,000
Selling, general and administrative
Business Acquisition [Line Items]
Allocated compensation expense	118,000,000	$ 92,000,000		311,000,000	$ 173,000,000
Juno
Business Acquisition [Line Items]
Other revenue	1,000,000		$ 1,000,000
Interest and investment income, net	3,000,000		3,000,000
Other income (expense), net	15,000,000		11,000,000
Income tax provision (benefit), net	(63,000,000)		(83,000,000)
Total	(270,000,000)		(574,000,000)
Allocated compensation expense	150,000,000			400,000,000
Acquisition related charges (income) and restructuring, net	0			41,000,000
Juno | Research and development
Business Acquisition [Line Items]
Business combination, expenses and losses recognized separately	225,000,000		385,000,000
Allocated compensation expense	100,000,000		233,000,000	233,000,000
Juno | Selling, general and administrative
Business Acquisition [Line Items]
Business combination, expenses and losses recognized separately	79,000,000		210,000,000
Allocated compensation expense	50,000,000		167,000,000	$ 167,000,000
Juno | Amortization of acquired intangible assets
Business Acquisition [Line Items]
Business combination, expenses and losses recognized separately	21,000,000		28,000,000
Juno | Acquisition related (gains) charges and restructuring, net
Business Acquisition [Line Items]
Business combination, expenses and losses recognized separately	$ 27,000,000		$ 49,000,000

Acquisitions (Juno- Pro Forma)

Acquisitions (Juno- Pro Forma) (Details) - USD ($) $ / shares in Units, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Feb. 28, 2018
Business Acquisition [Line Items]
Allocated compensation expense	$ 284	$ 170	$ 685	$ 323
Juno
Business Acquisition [Line Items]
Total revenue		3,272	7,362	6,234
Net income		$ 994	$ 1,805	$ 1,495
Net income per common share: basic (in dollars per share)		$ 1.27	$ 2.47	$ 1.92
Net income per common share: diluted (in dollars per share)		$ 1.22	$ 2.40	$ 1.84
Allocated compensation expense	$ 150		$ 400
Debt issuance costs					$ 4,500

Acquisitions (Delinia) (Details

Acquisitions (Delinia) (Details) - Delinia $ in Millions	Feb. 03, 2017USD ($)
Business Acquisition [Line Items]
Consideration transferred	$ 302
Net assets acquired	2
Research and development
Business Acquisition [Line Items]
Consideration transferred	300
Development Regulatory and Commercial Milestones
Business Acquisition [Line Items]
Potential milestone payment	$ 475

Acquisitions (Other Acquisition

Acquisitions (Other Acquisitions) (Details) - Privately Held Biotech - USD ($) $ in Millions	Feb. 03, 2017	Mar. 31, 2017
Business Acquisition [Line Items]
Consideration transferred		$ 26
Net assets acquired		1
Research and development
Business Acquisition [Line Items]
Acquisition expense		$ 25
Development and Regulatory Milestones
Business Acquisition [Line Items]
Potential milestone payment	$ 210

Earnings Per Share (Schedule of

Earnings Per Share (Schedule of Earnings Per Share) (Details) - USD ($) $ / shares in Units, shares in Millions, $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Earnings Per Share [Abstract]
Net income	$ 1,045	$ 1,101	$ 1,891	$ 2,033
Weighted-average shares:
Basic (in shares)	716.1	780.4	732.1	779.7
Effect of dilutive securities:
Options, restricted stock units, performance-based restricted stock units and other (in shares)	16.5	31.3	18.5	31.8
Diluted (in shares)	732.6	811.7	750.6	811.5
Net income per share:
Basic (in dollars per share)	$ 1.46	$ 1.41	$ 2.58	$ 2.61
Diluted (in dollars per share)	$ 1.43	$ 1.36	$ 2.52	$ 2.51

Earnings Per Share (Narrative)

Earnings Per Share (Narrative) (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	May 31, 2018	Feb. 28, 2018	Dec. 31, 2017
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive securities excluded from computation of earnings per share (in shares)	41,300,000	22,000,000
Additional authorized share repurchase program				$ 3,000,000,000	$ 5,000,000,000
Aggregate authorized amount	$ 28,500,000,000		$ 28,500,000,000
Accelerated share repurchases, repurchase agreement (shares)				$ 2,000,000,000
Accelerated share repurchases, shares repurchased	18,000,000		18,000,000
Accelerated share repurchases, value	$ 1,400,000,000		$ 1,400,000,000
Shares repurchased under share repurchase program (in shares)	32,800,000		61,800,000
Shares purchased under share repurchase program	$ 2,700,000,000		$ 5,400,000,000
Remaining authorized repurchase amount under stock purchase program	$ 2,800,000,000		$ 2,800,000,000
Purchased Put Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Put options outstanding (in shares)	0		0			0
Additional Paid-In Capital
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Accelerated share repurchases, value	$ 600,000,000		$ 600,000,000

Accumulated Other Comprehensi55

Accumulated Other Comprehensive Income (Loss) (Narrative) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Jan. 01, 2018	Sep. 30, 2017
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment					$ 452
Income before income taxes	$ 1,307	$ 1,178	$ 2,337	$ 2,192
Accounting Standards Update 2017-12
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Income before income taxes	$ 48		$ 37
Accumulated Other Comprehensive Income (Loss) | Accounting Standards Update 2017-12
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Cumulative effect adjustment						$ 30

Accumulated Other Comprehensi56

Accumulated Other Comprehensive Income (Loss) (Components of AOCI) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Jan. 01, 2018	Dec. 31, 2017	Dec. 31, 2016
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			$ 287	$ 419
Cumulative effect adjustment					$ 452
Other comprehensive (loss) income before reclassifications, net of tax			94	(75)
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			70	(144)
Total other comprehensive income (loss)	$ 209	$ (221)	164	(219)
Balance at the end of the period	(119)	170	(119)	170
Pension Liability Adjustment
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			(22)	(38)
Other comprehensive (loss) income before reclassifications, net of tax			0	0
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			0	0
Total other comprehensive income (loss)			0	0
Balance at the end of the period	(22)	(38)	(22)	(38)
Net Unrealized Gains (Losses) On Available-for-Sale Debt Securities / Marketable Securities (1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			562	144
Other comprehensive (loss) income before reclassifications, net of tax			(7)	148
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			14	21
Total other comprehensive income (loss)			7	169
Balance at the end of the period	3	313	3	313
Net Unrealized Gains (Losses) Related to Cash Flow Hedges
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			(206)	415
Other comprehensive (loss) income before reclassifications, net of tax			128	(259)
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			39	(165)
Total other comprehensive income (loss)			167	(424)
Balance at the end of the period	(43)	(21)	(43)	(21)
Amortization of Excluded Component Related to Cash Flow Hedges (See Note 1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			(15)	0
Other comprehensive (loss) income before reclassifications, net of tax			(15)	(5)
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			17	0
Total other comprehensive income (loss)			2	(5)
Balance at the end of the period	(13)	(23)	(13)	(23)
Foreign Currency Translation Adjustments
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Balance at the beginning of the period			(32)	(102)
Other comprehensive (loss) income before reclassifications, net of tax			(12)	41
Reclassified losses (gains) from accumulated other comprehensive income (loss), net of tax			0	0
Total other comprehensive income (loss)			(12)	41
Balance at the end of the period	$ (44)	$ (61)	$ (44)	$ (61)
Accounting Standards Update 2016-01 and 2018-02
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						$ (570)
Accounting Standards Update 2016-01 and 2018-02 | Pension Liability Adjustment
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						0
Accounting Standards Update 2016-01 and 2018-02 | Net Unrealized Gains (Losses) On Available-for-Sale Debt Securities / Marketable Securities (1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						(566)
Accounting Standards Update 2016-01 and 2018-02 | Net Unrealized Gains (Losses) Related to Cash Flow Hedges
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						(4)
Accounting Standards Update 2016-01 and 2018-02 | Amortization of Excluded Component Related to Cash Flow Hedges (See Note 1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						0
Accounting Standards Update 2016-01 and 2018-02 | Foreign Currency Translation Adjustments
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment						$ 0
ASU 2016-01
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment					$ 687
Accounting Standards Update 2017-12
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							$ (30)
Accounting Standards Update 2017-12 | Pension Liability Adjustment
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							0
Accounting Standards Update 2017-12 | Net Unrealized Gains (Losses) On Available-for-Sale Debt Securities / Marketable Securities (1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							0
Accounting Standards Update 2017-12 | Net Unrealized Gains (Losses) Related to Cash Flow Hedges
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							(12)
Accounting Standards Update 2017-12 | Amortization of Excluded Component Related to Cash Flow Hedges (See Note 1)
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							(18)
Accounting Standards Update 2017-12 | Foreign Currency Translation Adjustments
Accumulated Other Comprehensive Income (Loss) [Roll Forward]
Cumulative effect adjustment							$ 0

Accumulated Other Comprehensi57

Accumulated Other Comprehensive Income (Loss) (Reclassification of AOCI) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Other Comprehensive Income (Loss)
Total revenue	$ 3,814	$ 3,271	$ 7,352	$ 6,233
Interest (expense)	(192)	(126)	(358)	(253)
Income tax provision - (expense) benefit	262	77	446	159
Interest and investment income, net	9	24	22	39
Total reclassification, net of tax			(70)	144
(Losses) gains related to cash-flow hedges:
Other Comprehensive Income (Loss)
Total reclassification, net of tax			(39)	165
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income
Other Comprehensive Income (Loss)
Total reclassification, net of tax	(11)	62	(55)	149
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income | (Losses) gains related to cash-flow hedges: | Foreign exchange contracts
Other Comprehensive Income (Loss)
Total revenue	(12)	81	(38)	167
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income | (Losses) gains related to cash-flow hedges: | Treasury rate lock agreements
Other Comprehensive Income (Loss)
Interest (expense)	1	2	(2)	(3)
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income | (Losses) gains related to cash-flow hedges: | Interest rate swap agreements
Other Comprehensive Income (Loss)
Interest (expense)	0	0	0	(1)
Income tax provision - (expense) benefit	1	1	1	2
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income | Excluded component related to cash-flow hedges: | Foreign exchange contracts
Other Comprehensive Income (Loss)
Total revenue	1	3	(2)	5
Gains (Losses) Reclassified Out of Accumulated Other Comprehensive Income | (Losses) gains on available-for-sale debt securities / marketable securities (1):
Other Comprehensive Income (Loss)
Income tax provision - (expense) benefit	0	13	4	13
Interest and investment income, net	$ 0	$ (34)	$ (18)	$ (34)

Financial Instruments and Fai58

Financial Instruments and Fair Value Measurement (Assumption Calculations) (Details) - Significant Unobservable Inputs (Level 3) - Income Approach Valuation Technique - Obligations	Jun. 30, 2018	Dec. 31, 2017
Discount rate | Minimum
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0.025	0.027
Discount rate | Maximum
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0.040	0.120
Discount rate | Weighted Average
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0.032	0.035
Probability of payment | Minimum
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0	0
Probability of payment | Maximum
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0.68	0.20
Probability of payment | Weighted Average
Fair Value Inputs, Liabilities, Quantitative Information [Line Items] (Deprecated 2018-01-31)
Debt instrument, measurement input	0.046	0.04

Financial Instruments and Fai59

Financial Instruments and Fair Value Measurement (Narrative) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Dec. 31, 2017	Jun. 30, 2018
Business Acquisition [Line Items]
Unrealized gain (loss) on investments	$ (11)		$ 435
Nogra Pharma Limited
Business Acquisition [Line Items]
Decrease in contingent consideration		$ (1,397)
Maximum | Gloucester Pharmaceuticals, Inc.
Business Acquisition [Line Items]
Potential milestone payment	120		120
Maximum | Avila
Business Acquisition [Line Items]
Potential milestone payment	475		475
Maximum | Quanticel
Business Acquisition [Line Items]
Potential milestone payment	214		214
Maximum | Juno
Business Acquisition [Line Items]
Potential milestone payment	296		296
Maximum | Nogra Pharma Limited
Business Acquisition [Line Items]
Potential milestone payment	$ 1,800		$ 1,800

Financial Instruments and Fai60

Financial Instruments and Fair Value Measurement (Measurement Inputs) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Jan. 01, 2018	Dec. 31, 2017
Assets:
Debt securities available-for-sale	$ 79		$ 3,219
Equity investments with readily determinable fair values	1,828	$ 1,800	1,810
Forward currency contracts	27
Purchased currency options	33		36
Total assets	1,967		5,065
Liabilities:
Contingent value rights	(18)		(42)
Forward currency contracts			(42)
Interest rate swaps	(27)		(7)
Written currency options	(81)		(172)
Other acquisition related contingent consideration and success payments	(193)		(80)
Total liabilities	(319)		(343)
Quoted Price in Active Markets for Identical Assets (Level 1)
Assets:
Debt securities available-for-sale	0		0
Equity investments with readily determinable fair values	1,828		1,810
Forward currency contracts	0
Purchased currency options	0		0
Total assets	1,828		1,810
Liabilities:
Contingent value rights	(18)		(42)
Forward currency contracts			0
Interest rate swaps	0		0
Written currency options	0		0
Other acquisition related contingent consideration and success payments	0		0
Total liabilities	(18)		(42)
Significant Other Observable Inputs (Level 2)
Assets:
Debt securities available-for-sale	79		3,219
Equity investments with readily determinable fair values	0		0
Forward currency contracts	27
Purchased currency options	33		36
Total assets	139		3,255
Liabilities:
Contingent value rights	0		0
Forward currency contracts			(42)
Interest rate swaps	(27)		(7)
Written currency options	(81)		(172)
Other acquisition related contingent consideration and success payments	0		0
Total liabilities	(108)		(221)
Significant Unobservable Inputs (Level 3)
Assets:
Debt securities available-for-sale	0		0
Equity investments with readily determinable fair values	0		0
Forward currency contracts	0
Purchased currency options	0		0
Total assets	0		0
Liabilities:
Contingent value rights	0		0
Forward currency contracts			0
Interest rate swaps	0		0
Written currency options	0		0
Other acquisition related contingent consideration and success payments	(193)		(80)
Total liabilities	$ (193)		$ (80)

Financial Instruments and Fai61

Financial Instruments and Fair Value Measurement (Schedule of Remeasurement of Equity Investments) (Details) - Investments $ in Millions	6 Months Ended
	Jun. 30, 2018USD ($)
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance as of December 31, 2017	$ 513
Cumulative effect adjustment for the adoption of ASU 2018-03 (See Note 1)	59
Purchases	46
Upward adjustments	32
Sales	(23)
Downward adjustments	(1)
Impairments	(1)
Transfer to readily determinable fair value	(20)
Balance as of June 30, 2018	$ 605

Financial Instruments and Fai62

Financial Instruments and Fair Value Measurement (Level 3 Fair Value Roll-Forward) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Balance at beginning of period	$ (201)	$ (1,527)	$ (80)	$ (1,490)
Amounts acquired from Juno	6		116
Net change in fair value		(20)	(1)	17
Settlements, including transfers to Accrued expenses and other current liabilities	2	19	2	19
Balance at end of period	$ (193)	$ (1,488)	$ (193)	$ (1,488)

Derivative Instruments and He63

Derivative Instruments and Hedging Activities (Narrative) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Jan. 01, 2018
Derivative [Line Items]
Income before income taxes	$ 1,307	$ 1,178	$ 2,337	$ 2,192
Cumulative effect adjustment					$ 452
Foreign currency forward contracts | Minimum
Derivative [Line Items]
Derivative, remaining maturity			3 years
Foreign currency forward contracts | Maximum
Derivative [Line Items]
Derivative, remaining maturity			5 years
Accounting Standards Update 2017-12
Derivative [Line Items]
Income before income taxes	$ 48		$ 37

Derivative Instruments and He64

Derivative Instruments and Hedging Activities (Foreign Currency Forward Contracts) (Details) - Foreign currency forward contracts - USD ($) $ in Millions	6 Months Ended	12 Months Ended
	Jun. 30, 2018	Dec. 31, 2017
Derivatives not designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	$ 748	$ 885
Cash flow hedges | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	1,840	1,695
Cash flow hedges | Australian Dollar | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	46	61
Cash flow hedges | British Pound | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	134	97
Cash flow hedges | Canadian Dollar | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	190	227
Cash flow hedges | Euro | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	962	954
Cash flow hedges | Japanese Yen | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Notional Amount	$ 508	$ 356
Minimum
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, remaining maturity	3 years
Minimum | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, remaining maturity	36 months	33 months
Maximum
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, remaining maturity	5 years
Maximum | Derivatives designated as hedging instruments
Derivative Instruments, Gain (Loss) [Line Items]
Derivative, remaining maturity	20 months	20 months

Derivative Instruments and He65

Derivative Instruments and Hedging Activities (Foreign Currency Option Contracts) (Details) - Foreign exchange option contracts - USD ($) $ in Millions	6 Months Ended	12 Months Ended
	Jun. 30, 2018	Dec. 31, 2017
Purchased Put
Derivative [Line Items]
Notional Amount	$ 129	$ 258
Derivatives designated as hedging instruments | Purchased Put
Derivative [Line Items]
Notional Amount	2,756	3,319
Derivatives designated as hedging instruments | Written Call
Derivative [Line Items]
Notional Amount	$ 3,131	$ 3,739
Minimum | Purchased Put
Derivative [Line Items]
Derivative, remaining maturity	6 months	6 months
Minimum | Derivatives designated as hedging instruments
Derivative [Line Items]
Derivative, remaining maturity	30 months	30 months
Maximum | Purchased Put
Derivative [Line Items]
Derivative, remaining maturity	12 months	12 months
Maximum | Derivatives designated as hedging instruments
Derivative [Line Items]
Derivative, remaining maturity	36 months	36 months

Derivative Instruments and He66

Derivative Instruments and Hedging Activities (Interest Rate Swap Contracts) (Details) - USD ($) $ in Millions	6 Months Ended	12 Months Ended
	Jun. 30, 2018	Dec. 31, 2017	Feb. 28, 2018
3.875% senior notes due 2025
Derivative [Line Items]
Interest rate	3.875%
3.900% senior notes due 2028
Derivative [Line Items]
Interest rate	3.90%		3.90%
Senior notes | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Terminated swap contracts, notional amount	$ 150	$ 200
Gain on derivatives on settlement	3
Fair value hedges | Senior notes | Derivatives designated as hedging instruments (1) | Interest rate swap agreements
Derivative [Line Items]
Notional Amount	$ 950	450
Fair value hedges | Senior notes | Derivatives designated as hedging instruments (1) | 3.875% senior notes due 2025 | Interest rate swap agreements
Derivative [Line Items]
Interest rate	387.50%
Notional Amount	$ 200	200
Fair value hedges | Senior notes | Derivatives designated as hedging instruments (1) | 3.450% senior notes due 2027 | Interest rate swap agreements
Derivative [Line Items]
Interest rate	345.00%
Notional Amount	$ 550	250
Fair value hedges | Senior notes | Derivatives designated as hedging instruments (1) | 3.900% senior notes due 2028 | Interest rate swap agreements
Derivative [Line Items]
Interest rate	390.00%
Notional Amount	$ 200	$ 0

Derivative Instruments and He67

Derivative Instruments and Hedging Activities (Fair Value and Presentation in the Balance Sheet) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	$ 142	$ 93
Derivative liability, fair value, gross asset	190	278
Foreign exchange contracts | Derivatives designated as hedging instruments: | Other current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	56	5
Derivative liability, fair value, gross asset	29	1
Foreign exchange contracts | Derivatives designated as hedging instruments: | Other non-current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset		1
Derivative liability, fair value, gross asset		0
Foreign exchange contracts | Derivatives designated as hedging instruments: | Other non-current liabilities
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross liability	34	36
Derivative liability, fair value, gross liability	68	159
Foreign exchange contracts | Derivatives designated as hedging instruments: | Accrued expenses and other current liabilities
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross liability	4	30
Derivative liability, fair value, gross liability	10	79
Foreign exchange contracts | Derivatives not designated as hedging instruments: | Other non-current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	4
Derivative liability, fair value, gross asset	0
Interest rate swap agreements | Derivatives designated as hedging instruments: | Other current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	7	3
Derivative liability, fair value, gross asset	0	0
Interest rate swap agreements | Derivatives designated as hedging instruments: | Other non-current liabilities
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross liability	0	0
Derivative liability, fair value, gross liability	36	11
Interest rate swap agreements | Derivatives not designated as hedging instruments: | Other current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	2	2
Derivative liability, fair value, gross asset	1	2
Interest rate swap agreements | Derivatives not designated as hedging instruments: | Other non-current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	7	4
Derivative liability, fair value, gross asset	6	3
Foreign exchange contracts | Derivatives not designated as hedging instruments: | Other current assets
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross asset	25	8
Derivative liability, fair value, gross asset	3	1
Foreign exchange contracts | Derivatives not designated as hedging instruments: | Accrued expenses and other current liabilities
Derivatives, Fair Value [Line Items]
Derivative asset, fair value, gross liability	3	4
Derivative liability, fair value, gross liability	$ 37	$ 22

Derivative Instruments and He68

Derivative Instruments and Hedging Activities (Cumulative Basis Adjustments For Fair Value Hedges) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Feb. 28, 2018	Dec. 31, 2017
Derivative [Line Items]
Current portion of long-term debt, net of discount	$ 1,497		$ 0
Long-term debt, net of discount	19,754	$ 1,000	15,838
Carrying Amount of the Hedged Liability
Derivative [Line Items]
Current portion of long-term debt, net of discount	503		0
Long-term debt, net of discount	8,173		7,270
Cumulative Amount of Fair Value Hedging Adjustment Included in the Carrying Amount of the Hedged Liability
Derivative [Line Items]
Current portion of long-term debt, net of discount	4		0
Long-term debt, net of discount	84		128
Hedging Adjustment Discontinued Hedging Relationship ASU 2017-12 | Carrying Amount of the Hedged Liability
Derivative [Line Items]
Long-term debt, net of discount	3,200		3,800
Hedging Adjustment Discontinued Hedging Relationship ASU 2017-12 | Cumulative Amount of Fair Value Hedging Adjustment Included in the Carrying Amount of the Hedged Liability
Derivative [Line Items]
Long-term debt, net of discount	$ 120		$ 139

Derivative Instruments and He69

Derivative Instruments and Hedging Activities (Schedule of Impacts on Income) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing	$ 12	$ (80)	$ 39	$ (165)
Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Foreign currency cash flow hedge gain (loss) to be reclassified during next 12 months	(7)		(7)
Gain (loss) from components excluded from assessment of cash flow hedge effectiveness, net			(2)
Foreign exchange contracts | Other income (expense), net | Derivatives not designated as hedging instruments
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in OCI on Derivative	22	(19)	9	(42)
Cash flow hedges | Foreign exchange contracts | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in OCI on Derivative	226	(181)	131	(249)
Cash flow hedges | Foreign exchange contracts | Net product sales | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Reclassified from Accumulated OCI into Income	(12)	81	(38)	167
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing	1	3	(2)	5
Cash flow hedges | Foreign exchange contracts | Other income (expense), net | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing		1
Cash flow hedges | Treasury rate lock agreements | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in OCI on Derivative	0	0	(4)	0
Cash flow hedges | Treasury rate lock agreements | Net product sales | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing				0
Cash flow hedges | Treasury rate lock agreements | Interest (expense) | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Reclassified from Accumulated OCI into Income	(1)	(2)	(2)	(3)
Cash flow hedges | Treasury rate lock agreements | Other income (expense), net | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing			0
Cash flow hedges | Interest rate swap agreements | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in OCI on Derivative		(17)		(17)
Cash flow hedges | Interest rate swap agreements | Interest (expense) | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Reclassified from Accumulated OCI into Income		0		(1)
Fair value hedges | Interest rate swap agreements | Interest (expense) | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing	(2)	11	(7)	20
Accounting Standards Update 2017-12 | Fair value hedges | Interest rate swap agreements | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing	8	9	16	18
Accounting Standards Update 2017-12 | Fair value hedges | Interest rate swap agreements | Interest (expense) | Derivatives designated as hedging instruments (1)
Derivative [Line Items]
Amount of Gain/(Loss) Recognized in Income on Derivative Related to Amount Excluded from Effectiveness Testing	$ 8	$ 9	$ 16	$ 18

Derivative Instruments and He70

Derivative Instruments and Hedging Activities (Location and Amount of Gain or (Loss) Recognized in Income on Fair Value and Cash Flow Hedging Relationships) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Derivative [Line Items]
Gain (loss) on fair value hedging relationships			$ (8)	$ (60)
Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value	$ 12	$ (80)	39	(165)
Net product sales | Interest rate swap agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income				0
Net product sales | Treasury rate lock agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	0	0	0	0
Interest (expense)
Derivative [Line Items]
Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded	(192)	(126)	(358)	(253)
Interest (expense) | Interest rate swap agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income				(1)
Interest (expense) | Treasury rate lock agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	(1)	(2)	(2)	(3)
Other income (expense), net
Derivative [Line Items]
Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded	4	(31)	969	(18)
Other income (expense), net | Interest rate swap agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income				0
Other income (expense), net | Treasury rate lock agreements
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	0	0	0	0
Effects of Fair Value and Cash Flow Hedging | Net product sales | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	0	0	0	0
Effects of Fair Value and Cash Flow Hedging | Interest (expense) | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	11	(2)	25	(1)
Effects of Fair Value and Cash Flow Hedging | Other income (expense), net | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	0	0	0	0
Cash flow hedges | Net product sales | Foreign exchange contracts
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	(12)	81	(38)	167
Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value	7	3	15	5
Reclassification adjustment for excluded component (loss) gain	(6)		0
Cash flow hedges | Interest (expense) | Foreign exchange contracts
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	0	0	0	0
Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value	0	0	0	0
Cash flow hedges | Other income (expense), net | Foreign exchange contracts
Derivative [Line Items]
Amount of gain or (loss) reclassified from AOCI into income	0	0	0	0
Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value	0	1	0	8
Derivatives designated as hedging instruments | Effects of Fair Value and Cash Flow Hedging | Net product sales | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	0	0	0	0
Derivatives designated as hedging instruments | Effects of Fair Value and Cash Flow Hedging | Interest (expense) | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	(2)	11	(7)	20
Derivatives designated as hedging instruments | Effects of Fair Value and Cash Flow Hedging | Other income (expense), net | Interest rate swap agreements
Derivative [Line Items]
Gain (loss) on fair value hedging relationships	0	0	0	0
Accounting Standards Update 2017-12 | Derivatives designated as hedging instruments | Fair value hedges | Interest rate swap agreements
Derivative [Line Items]
Amount excluded from effectiveness testing recognized using a systematic and rational amortization approach / changes in fair value	8	9	16	18
Net product sales | Net product sales
Derivative [Line Items]
Total amounts of income and expense line items presented in the Consolidated Statements of Income in which the effects of fair value or cash flow hedges are recorded	$ 3,808	$ 3,259	$ 7,339	$ 6,211

Cash, Cash Equivalents, Debt 71

Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values (Narrative) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Cash, Cash Equivalents, and Short-term Investments [Abstract]
Time deposits and repurchase agreements	$ 11	$ 1,200
Commercial paper		35
Money market funds, at carrying value	507	4,500
Equity investments with readily determinable fair values	$ 1,828	$ 1,810

Cash, Cash Equivalents, Debt 72

Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values (Schedule of Available-for-Sale Reconciliation) (Details) - USD ($)	Jun. 30, 2018	Dec. 31, 2017
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	$ 79,000,000	$ 3,228,000,000
Gross Unrealized Gain	0	0
Gross Unrealized Loss	0	(9,000,000)
Estimated Fair Value	79,000,000	3,219,000,000
U.S. Treasury securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		445,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		(3,000,000)
Estimated Fair Value		442,000,000
U.S. government-sponsored agency securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		42,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		0
Estimated Fair Value		42,000,000
U.S. government-sponsored agency MBS
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		17,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		0
Estimated Fair Value		17,000,000
Corporate debt - global
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		2,080,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		(5,000,000)
Estimated Fair Value		2,075,000,000
Asset backed securities
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		203,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		(1,000,000)
Estimated Fair Value		202,000,000
Ultra short income fund
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		352,000,000
Gross Unrealized Gain		0
Gross Unrealized Loss		0
Estimated Fair Value		352,000,000
Time deposits and Repurchase agreements
Debt Securities, Available-for-sale [Line Items]
Amortized Cost	79,000,000	89,000,000
Gross Unrealized Gain	0	0
Gross Unrealized Loss	0	0
Estimated Fair Value	$ 79,000,000	89,000,000
Equity securities with readily determinable fair values
Debt Securities, Available-for-sale [Line Items]
Amortized Cost		935
Gross Unrealized Gain		881
Gross Unrealized Loss		(6)
Estimated Fair Value		$ 1,810

Cash, Cash Equivalents, Debt 73

Cash, Cash Equivalents, Debt Securities Available-for-Sale and Equity Investments with Readily Determinable Fair Values (Duration Periods) (Details) $ in Millions	Jun. 30, 2018USD ($)
Amortized Cost
Duration of one year or less	$ 79
Fair Value
Duration of one year or less	$ 79

Inventory (Details)

Inventory (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Inventory Disclosure [Abstract]
Raw materials	$ 344	$ 289
Work in process	68	89
Finished goods	143	163
Total	$ 555	$ 541

Intangible Assets and Goodwil75

Intangible Assets and Goodwill (Summary of Intangible Assets) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Intangible Assets By Category
Gross Carrying Value	$ 5,269	$ 3,998
Accumulated Amortization	(2,630)	(2,413)
Intangible Assets, Net	2,639	1,585
Total intangible assets
Gross Carrying Value	19,100	10,849
Intangible Assets, Net	16,470	8,436
Acquired developed product rights
Intangible Assets By Category
Gross Carrying Value	3,406	3,406
Accumulated Amortization	(2,087)	(1,939)
Intangible Assets, Net	1,319	1,467
Technology
Intangible Assets By Category
Gross Carrying Value	1,743	483
Accumulated Amortization	(474)	(410)
Intangible Assets, Net	1,269	73
Licenses
Intangible Assets By Category
Gross Carrying Value	66	66
Accumulated Amortization	(32)	(30)
Intangible Assets, Net	34	36
Other
Intangible Assets By Category
Gross Carrying Value	54	43
Accumulated Amortization	(37)	(34)
Intangible Assets, Net	17	9
Acquired IPR&D product rights
Non-amortizable intangible assets:
Carrying value	$ 13,831	$ 6,851

Intangible Assets and Goodwil76

Intangible Assets and Goodwill (Narrative) (Details) - USD ($) $ in Millions	3 Months Ended		6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017	Dec. 31, 2017
Business Acquisition [Line Items]
Intangible asset, useful life			8 years 11 months
Finite intangible asset	$ 5,269		$ 5,269		$ 3,998
Amortization of acquired intangible assets	129	$ 89	217	$ 173
Finite-Lived Intangible Assets, Net, Amortization Expense, Fiscal Year Maturity [Abstract]
Future annual amortization, 2018	474		474
Future annual amortization, 2019	442		442
Future annual amortization, 2020	440		440
Future annual amortization, 2021	438		438
Future annual amortization, 2022	179		179
Juno
Finite-Lived Intangible Assets, Net, Amortization Expense, Fiscal Year Maturity [Abstract]
Goodwill, period increase (decrease)			8,000
Acquired IPR&D product rights
Business Acquisition [Line Items]
Intangible asset	13,831		13,831		6,851
Acquired IPR&D product rights | Juno
Business Acquisition [Line Items]
Intangible asset	7,000		7,000
Technology
Business Acquisition [Line Items]
Finite intangible asset	1,743		$ 1,743		$ 483
Technology | Juno
Business Acquisition [Line Items]
Intangible asset, useful life			15 years
Finite intangible asset	$ 1,300		$ 1,300

Debt (Short-Term Borrowings and

Debt (Short-Term Borrowings and Current Portion of Long-Term Debt) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Short-term Debt [Line Items]
Current portion of long-term debt, net of discount	$ 1,497	$ 0
Commercial paper
Short-term Debt [Line Items]
Current portion of long-term debt, net of discount	995	0
2.250% senior notes due 2019
Short-term Debt [Line Items]
Current portion of long-term debt, net of discount	$ 502	$ 0
Interest rate	2.25%

Debt (Narrative) (Details)

Debt (Narrative) (Details) - USD ($)	1 Months Ended
	Feb. 28, 2018	Jun. 30, 2018	Dec. 31, 2017	Apr. 30, 2016
Debt
Long-term debt	$ 1,000,000,000	$ 19,754,000,000	$ 15,838,000,000
Treasury rate lock agreements
Debt
Losses recorded to AOCI		33,000,000	31,000,000
Interest rate swap agreements | Derivatives designated as hedging instruments
Debt
Gains recorded as reduction of debt		125,000,000	139,000,000
Commercial paper
Debt
Maximum borrowing capacity		2,000,000,000	2,000,000,000	$ 2,000,000,000
Short-term debt		$ 995,000,000
Effective interest rate		2.30%
Revolving Credit Facility
Debt
Long-term line of credit		$ 0	0
Level 2
Debt
Senior notes, fair value		19,600,000,000	16,600,000,000
2.875% senior notes due 2021
Debt
Long-term debt	$ 500,000,000	$ 498,000,000	0
Interest rate	2.875%	2.875%
Offering price as percent of par	99.954%
Basis spread	10.00%
3.250% senior notes due 2023
Debt
Long-term debt		$ 993,000,000	0
Interest rate	3.25%	3.25%
Offering price as percent of par	99.758%
Basis spread	15.00%
3.900% senior notes due 2028
Debt
Long-term debt	$ 1,500,000,000	$ 1,486,000,000	0
Interest rate	3.90%	3.90%
Offering price as percent of par	99.656%
Basis spread	20.00%
4.550% senior notes due 2048
Debt
Long-term debt	$ 1,500,000,000	$ 1,476,000,000	$ 0
Interest rate	4.55%	4.55%
Offering price as percent of par	99.40%
Basis spread	25.00%
Senior notes
Debt
Debt issuance costs		$ 32,000,000
Debt redemption rate	100.00%
Redemption price, downgrade	101.00%

Debt (Senior Notes Carrying Val

Debt (Senior Notes Carrying Values) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Feb. 28, 2018	Dec. 31, 2017
Carrying values of the entity's senior notes
Long-term debt	$ 19,754	$ 1,000	$ 15,838
2.250% senior notes due 2019
Carrying values of the entity's senior notes
Long-term debt	$ 0		505
Interest rate	2.25%
2.875% senior notes due 2020
Carrying values of the entity's senior notes
Long-term debt	$ 1,496		1,495
Interest rate	2.875%
3.950% senior notes due 2020
Carrying values of the entity's senior notes
Long-term debt	$ 511		514
Interest rate	3.95%
2.250% senior notes due 2021
Carrying values of the entity's senior notes
Long-term debt	$ 497		497
Interest rate	2.25%
2.875% senior notes due 2021
Carrying values of the entity's senior notes
Long-term debt	$ 498	$ 500	0
Interest rate	2.875%	2.875%
3.250% senior notes due 2022
Carrying values of the entity's senior notes
Long-term debt	$ 1,039		1,044
Interest rate	3.25%
3.550% senior notes due 2022
Carrying values of the entity's senior notes
Long-term debt	$ 995		994
Interest rate	3.55%
2.750% senior notes due 2023
Carrying values of the entity's senior notes
Long-term debt	$ 746		746
Interest rate	2.75%
3.250% senior notes due 2023
Carrying values of the entity's senior notes
Long-term debt	$ 993		0
Interest rate	3.25%	3.25%
4.000% senior notes due 2023
Carrying values of the entity's senior notes
Long-term debt	$ 734		737
Interest rate	4.00%
3.625% senior notes due 2024
Carrying values of the entity's senior notes
Long-term debt	$ 1,001		1,001
Interest rate	3.625%
3.875% senior notes due 2025
Carrying values of the entity's senior notes
Long-term debt	$ 2,472		2,478
Interest rate	3.875%
3.450% senior notes due 2027
Carrying values of the entity's senior notes
Long-term debt	$ 974		991
Interest rate	3.45%
3.900% senior notes due 2028
Carrying values of the entity's senior notes
Long-term debt	$ 1,486	$ 1,500	0
Interest rate	3.90%	3.90%
5.700% senior notes due 2040
Carrying values of the entity's senior notes
Long-term debt	$ 247		247
Interest rate	5.70%
5.250% senior notes due 2043
Carrying values of the entity's senior notes
Long-term debt	$ 393		393
Interest rate	5.25%
4.625% senior notes due 2044
Carrying values of the entity's senior notes
Long-term debt	$ 987		987
Interest rate	4.625%
5.000% senior notes due 2045
Carrying values of the entity's senior notes
Long-term debt	$ 1,975		1,975
Interest rate	5.00%
4.350% senior notes due 2047
Carrying values of the entity's senior notes
Long-term debt	$ 1,234		1,234
Interest rate	4.35%
4.550% senior notes due 2048
Carrying values of the entity's senior notes
Long-term debt	$ 1,476	$ 1,500	$ 0
Interest rate	4.55%	4.55%
Senior notes
Carrying values of the entity's senior notes
Long-term debt	$ 19,850

Share-Based Compensation (Narra

Share-Based Compensation (Narrative) (Details) shares in Millions	Jun. 30, 2018shares
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Shares reserved (in shares)	13.9

Share-Based Compensation (Compo

Share-Based Compensation (Components of Share-Based Compensation Expense) (Details) - USD ($) $ in Millions	3 Months Ended		4 Months Ended	6 Months Ended
	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2018	Jun. 30, 2017
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	$ 284	$ 170		$ 685	$ 323
Tax benefit related to share-based compensation expense	37	46		74	87
Reduction in net income	247	124		611	236
Proceeds and excess tax benefit from share-based compensation	5	95		16	170
Cost of goods sold (excluding amortization of acquired intangible assets)
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	9	8		18	15
Research and development
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	157	70		356	135
Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	118	$ 92		311	$ 173
Juno
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	150			400
Juno | Research and development
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	100		$ 233	233
Juno | Selling, general and administrative
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items]
Total share-based compensation expense	$ 50		$ 167	$ 167

Share-Based Compensation (Summa

Share-Based Compensation (Summary of Stock Options, RSUs and PSUs) (Details) shares in Thousands	6 Months Ended
	Jun. 30, 2018shares
Stock Options
Stock option activity
Outstanding as of December 31, 2017	67,800
Conversion of Juno awards	3,700
Granted	6,800
Exercised / Released	(3,500)
Forfeited	(1,800)
Outstanding as of June 30, 2018	73,000
RSUs
Restricted and Performance-Based Restricted Stock Units
Outstanding as of December 31, 2017	7,700
Conversion of Juno awards	2,500
Granted	3,400
Exercised / Released	(2,100)
Forfeited	(400)
Outstanding as of June 30, 2018	11,100
PSUs
Restricted and Performance-Based Restricted Stock Units
Outstanding as of December 31, 2017	558
Conversion of Juno awards	336
Granted	162
Exercised / Released	(247)
Forfeited	(28)
Outstanding as of June 30, 2018	781

Share-Based Compensation (Unves

Share-Based Compensation (Unvested Awards and Weighted-Average Periods) (Details) $ in Millions	6 Months Ended
	Jun. 30, 2018USD ($)
Stock Options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	$ 641
Expected weighted-average period in years of compensation cost to be recognized	2 years 2 months 12 days
RSUs
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	$ 566
Expected weighted-average period in years of compensation cost to be recognized	1 year 10 months 24 days
PSUs
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation cost	$ 43
Expected weighted-average period in years of compensation cost to be recognized	1 year 6 months

Income Taxes (Details)

Income Taxes (Details) $ in Millions	6 Months Ended
	Jun. 30, 2018USD ($)
Income Tax Disclosure [Abstract]
Gross unrecognized tax benefits, increase	$ 200
Increases to the amount of unrecognized tax benefits, prior period	$ 38

Collaboration Agreements (Detai

Collaboration Agreements (Details) - USD ($) $ in Millions	Mar. 20, 2018	Mar. 01, 2018	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Prothena
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Subscriptions receivable (in shares)	$ 1.2
Upfront payments made	$ 150				$ 110
Term of agreement	6 years
Optional contract extension period	2 years
Vividion
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made		$ 101			97
Term of agreement		4 years
Optional contract extension period		2 years
Other Collaboration Arrangements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made			$ 146	$ 75	184	$ 85
Research and Development, Payments | Prothena
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made	$ 110
Research and Development, Payments | Vividion
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made		$ 97
Equity Investment, Readily Determinable Fair Value | Prothena
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made	$ 40
Equity Investment, Readily Determinable Fair Value | Vividion
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payments made		$ 4
Maximum | Other Collaboration Arrangements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Future potential milestone payments					$ 177

Collaboration Agreements (Sched

Collaboration Agreements (Schedule of Collaboration Agreements) (Details) - USD ($) $ in Millions	Mar. 20, 2018	Mar. 01, 2018	Jun. 30, 2018	Jun. 30, 2017	Jun. 30, 2018	Jun. 30, 2017
Prothena
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront Fees	$ 150				$ 110
Milestones					0
Extension/Termination of Arrangements					0
Amortization of Prepaid Research and Development					0
Equity Investments Made During Period					40
Vividion
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront Fees		$ 101			97
Milestones					0
Extension/Termination of Arrangements					0
Amortization of Prepaid Research and Development					0
Equity Investments Made During Period					4
Other Collaboration Arrangements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront Fees			$ 146	$ 75	184	$ 85
Milestones			15	0	15	0
Extension/Termination of Arrangements			4	0	4	7
Amortization of Prepaid Research and Development			2	3	4	7
Equity Investments Made During Period			$ 20	$ 67	$ 77	$ 79

Collaboration Agreements (Perio

Collaboration Agreements (Period End Balances) (Details) - USD ($) $ in Millions	Jun. 30, 2018	Dec. 31, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Intangible Asset Balance	$ 16,470	$ 8,436
Prothena
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Intangible Asset Balance	0
Equity Investment Balance	$ 17
Percentage of Outstanding Equity	2.90%
Vividion
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Intangible Asset Balance	$ 0
Equity Investment Balance	$ 4
Percentage of Outstanding Equity	5.80%
Other Collaboration Arrangements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Intangible Asset Balance	$ 7	12
Equity Investment Balance	$ 1,710	$ 1,806

Legal Proceedings (Narrative) (

Legal Proceedings (Narrative) (Details) $ in Thousands	Aug. 22, 2017USD ($)	Jun. 14, 2017plaintiff
Loss Contingencies [Line Items]
Number of plaintiffs | plaintiff		3
City of Hope
Loss Contingencies [Line Items]
Damages sought | $	$ 93,750