Zila (ZILA) 8-K Departure of Directors or Principal Officers

Exhibit 17.1

Kurt Krauss
225 Lake Bluff Drive
Columbus, Ohio

May 15, 2007

Mr. Gary Klinefelter
General Counsel & Secretary
Zila, Inc.
5227 N. 7^th Street
Phoenix, AZ 85104

Dear Gary:

I hereby tender my resignation from the Board of Directors of Zila, Inc. because I believe I can no longer faithfully fulfill my fiduciary responsibilities to the Company and its stockholders as a result of my lack of confidence in the Company’s Chief Executive Officer and concerns regarding the Company’s corporate governance practices. I also resign as Chairman of the Audit Committee and as a member of the Compensation Committee of Zila, Inc.

These resignations are effective immediately.

Respectfully,
 

/s/ Kurt Krauss  

Kurt Krauss