Pressure BioSciences (PBIO) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

April 22, 2010

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C.  20549-7561

Commissioners:

We have read the paragraphs included in Item 4.01(a) of Form 8-K of Pressure Biosciences, Inc. dated April 19, 2010, expected to be filed with the Securities and Exchange Commission on April 23, 2010 and are in agreement with the statements concerning our Firm in those paragraphs.

We have no basis to agree or disagree with the other statements included in such Form 8-K.

Very truly yours,

/s/ UHY LLP

Houston, Texas