| Cover | Aug. 18, 2021 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Aug. 18, 2021 |
| Entity File Number | 001-38185 |
| Entity Registrant Name | PRESSURE BIOSCIENCES, INC. |
| Entity Central Index Key | 0000830656 |
| Entity Tax Identification Number | 04-2652826 |
| Entity Incorporation, State or Country Code | MA |
| Entity Address, Address Line One | 14 Norfolk Avenue |
| Entity Address, City or Town | South Easton |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 02375 |
| City Area Code | (508) |
| Local Phone Number | 230-1828 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Entity Emerging Growth Company | false |
