Pressure BioSciences (PBIO) 10-Q 17 Nov 21 2021 Q3 Quarterly report Financial data

Cover

Cover - shares	9 Months Ended
	Sep. 30, 2021	Nov. 10, 2021
Cover [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Quarterly Report	true
Document Transition Report	false
Document Period End Date	Sep. 30, 2021
Document Fiscal Period Focus	Q3
Document Fiscal Year Focus	2021
Current Fiscal Year End Date	--12-31
Entity File Number	001-38185
Entity Registrant Name	PRESSURE BIOSCIENCES, INC.
Entity Central Index Key	0000830656
Entity Tax Identification Number	04-2652826
Entity Incorporation, State or Country Code	MA
Entity Address, Address Line One	14 Norfolk Avenue
Entity Address, City or Town	South Easton
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02375
City Area Code	(508)
Local Phone Number	230-1828
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		7,391,391

Consolidated Balance Sheets (Un

Consolidated Balance Sheets (Unaudited) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
CURRENT ASSETS
Cash and cash equivalents	$ 663,651	$ 18,540
Accounts receivable	538,632	131,228
Inventories, net of $342,496 reserve at September 30, 2021 and December 31, 2020	796,418	592,767
Prepaid expenses and other current assets	620,960	314,936
Total current assets	2,619,661	1,057,471
Investment in equity securities	112,550	517,001
Property and equipment, net	2,366	16,490
Right of use asset leases	173,274	221,432
Intangible assets, net	425,481	490,385
TOTAL ASSETS	3,333,332	2,302,779
CURRENT LIABILITIES
Accounts payable	418,020	771,945
Accrued employee compensation	142,375	417,578
Accrued professional fees and other	2,021,783	2,037,806
Other current liabilities	7,108,447	6,330,722
Deferred revenue	44,176	47,328
Convertible debt, net of unamortized discounts of $2,692,163 and $3,948,167, respectively	11,760,299	7,545,670
Other debt, net of unamortized discounts of $1,291 and $0, respectively	1,070,526	1,135,469
Operating lease liability	71,301	65,193
Other related party debt	38,000	166,000
Total current liabilities	22,674,927	18,517,711
LONG TERM LIABILITIES
Long term debt	527,038	527,039
Operating lease liability – long term	101,973	156,239
Deferred revenue	8,654	19,382
TOTAL LIABILITIES	23,312,592	19,220,371
COMMITMENTS AND CONTINGENCIES (Note 4)
STOCKHOLDERS’ DEFICIT
Common stock, $.01 par value; 100,000,000 shares authorized; 8,345,120 and 4,168,324 shares issued and outstanding on September 30, 2021 and December 31, 2020 respectively	83,451	41,683
Warrants to acquire common stock	31,607,879	29,192,471
Additional paid-in capital	62,307,524	50,312,968
Accumulated deficit	(113,979,213)	(96,465,807)
Total stockholders’ deficit	(19,979,260)	(16,917,592)
TOTAL LIABILITIES AND STOCKHOLDERS’ DEFICIT	3,333,332	2,302,779
Series D Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	3	3
Series G Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	806	806
Series H Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	100	100
Series H2 Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock
Series J Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	35	35
Series K Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	68	68
Series AA Convertible Preferred Stock [Member]
STOCKHOLDERS’ DEFICIT
Convertible preferred stock	$ 87	$ 81

Consolidated Balance Sheets (_2

Consolidated Balance Sheets (Unaudited) (Parenthetical) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Inventory Valuation Reserves	$ 342,496	$ 342,496
Debt Instrument, Unamortized Discount	2,692,163	3,948,167
Other debt, unamortized discounts net.	$ 1,291	$ 0
Common stock, par value	$ 0.01	$ 0.01
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	8,345,120	4,168,324
Common stock, shares outstanding	8,345,120	4,168,324
Series D Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	850	850
Preferred stock, shares issued	300	300
Preferred stock, shares outstanding	300	300
Series G Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	240,000	240,000
Preferred stock, shares issued	80,570	80,570
Preferred stock, shares outstanding	80,570	80,570
Series H Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	10,000	10,000
Preferred stock, shares issued	10,000	10,000
Preferred stock, shares outstanding	10,000	10,000
Series H2 Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	21	21
Preferred stock, shares issued	21	21
Preferred stock, shares outstanding	21	21
Series J Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	6,250	6,250
Preferred stock, shares issued	3,458	3,458
Preferred stock, shares outstanding	3,458	3,458
Series K Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	15,000	15,000
Preferred stock, shares issued	6,880	6,880
Preferred stock, shares outstanding	6,880	6,880
Series AA Convertible Preferred Stock [Member]
Preferred stock, par value	$ 0.01	$ 0.01
Preferred stock, shares authorized	10,000	10,000
Preferred stock, shares issued	8,649	8,043
Preferred stock, shares outstanding	8,649	8,043

Consolidated Statements of Oper

Consolidated Statements of Operations (Unaudited) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Revenue:
Total revenue	$ 518,365	$ 533,862	$ 1,687,166	$ 1,055,889
Costs and expenses:
Cost of products and services	258,170	247,013	771,105	557,041
Research and development	282,622	247,432	839,072	807,724
Selling and marketing	66,068	173,372	252,209	524,586
General and administrative	1,154,063	684,807	2,788,779	2,711,032
Total operating costs and expenses	1,760,923	1,352,624	4,651,165	4,600,383
Operating loss	(1,242,558)	(818,762)	(2,963,999)	(3,544,494)
Other (expense) income:
Interest expense, net	(3,330,101)	(2,204,593)	(11,524,306)	(5,501,272)
Unrealized (loss) gain on investment in equity securities	(162,071)	140,461	(404,451)	486,723
Loss on extinguishment of liabilities	(277,010)	(395,854)	(1,500,395)	(3,242,372)
Other income	60,627		119,280
Total other expense	(3,708,555)	(2,459,986)	(13,309,872)	(8,256,921)
Net loss	(4,951,113)	(3,278,748)	(16,273,871)	(11,801,415)
Deemed dividends on beneficial conversion feature	(815,914)		(873,798)
Preferred stock dividends	(432,149)	(396,970)	(1,239,535)	(1,118,526)
Net loss attributable to common stockholders	$ (6,199,176)	$ (3,675,718)	$ (18,387,204)	$ (12,919,941)
Basic and diluted net loss per share attributable to common stockholders	$ (0.82)	$ (1.02)	$ (3.02)	$ (4.22)
Weighted average common stock shares outstanding used in the basic and diluted net loss per share calculation	7,561,728	3,612,958	6,083,017	3,059,095
Products, Services, Other [Member]
Revenue:
Total revenue	$ 518,365	$ 533,862	$ 1,687,166	$ 1,055,889

Consolidated Statements of Cash

Consolidated Statements of Cash Flows (Unaudited) - USD ($)	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss	$ (16,273,871)	$ (11,801,415)
Adjustments to reconcile net loss to net cash used in operating activities:
Gain on loan forgiveness	(367,039)
Non-cash lease expense	48,158	55,628
Common stock and warrants issued for interest and extension fees	6,208,696	242,350
Depreciation and amortization	83,531	103,424
Accretion of interest and amortization of debt discount	5,308,424	3,454,470
Loss on extinguishment of accrued liabilities and debt	23,004	1,036,638
Stock-based compensation expense	219,943	373,652
Loss (Gain) on investment in equity securities	404,451	(486,723)
Common stock issued for services	579,512	87,963
Changes in operating assets and liabilities:
Accounts receivable	(407,404)	(101,057)
Inventories	(203,651)	101,511
Prepaid expenses and other assets	(306,024)	53,810
Accounts payable	(336,675)	(109,445)
Accrued employee compensation	39,801	(609)
Operating lease liability	(48,158)	(55,628)
Deferred revenue and other accrued expenses	943,400	3,138,667
Net cash used in operating activities	(4,083,902)	(3,906,764)
CASH FLOWS FROM INVESTING ACTIVITIES:
Advance on loan receivable		(801,250)
Purchases of property plant and equipment	(4,503)	(1,663)
Net cash used in investing activities	(4,503)	(802,913)
CASH FLOWS FROM FINANCING ACTIVITIES:
Net proceeds from Series AA Convertible Preferred Stock	1,015,000
Proceeds from stock option exercises	14,773
Net proceeds from convertible debt	5,054,500	6,977,800
Net proceeds from non-convertible debt – third party	1,610,688	990,539
Net proceeds from non-convertible debt – related party	194,600	38,500
Payments on convertible debt	(1,608,295)	(1,972,007)
Payments on non-convertible debt – related party	(256,600)	(15,000)
Payments on non-convertible debt	(1,291,150)	(1,245,028)
Net cash provided by financing activities	4,733,516	4,774,804
NET INCREASE IN CASH AND CASH EQUIVALENTS	645,111	65,127
CASH AND CASH EQUIVALENTS AT BEGINNING OF YEAR	18,540	29,625
CASH AND CASH EQUIVALENTS AT END OF PERIOD	663,651	94,752
SUPPLEMENTAL INFORMATION
Interest paid in cash	802,084	530,009
NON CASH TRANSACTIONS:
Common stock issued for non-cash warrant exercise	363
Loan extension fees and interest added to principal		152,552
Common stock issued to settle accrued liabilities		127,855
Common stock issued with debt	551,198	147,775
Discount from warrants issued with debt	1,403,546	4,261,055
Common stock issued in lieu of cash for dividend	114,298	221,374
Preferred stock dividends	1,239,535	1,118,526
Conversion of debt and interest into common stock	2,589,990	1,830,543
Discount due to beneficial conversion feature	1,231,528	1,353,694
Deemed dividend - beneficial conversion feature	873,798
Conversion of accrued liabilities and debt for Series AA preferred stock	500,250	110,000
Common stock issued for debt settlement		$ 374,550

Consolidated Statements of Chan

Consolidated Statements of Changes in Stockholder's Deficit (Unaudited) - USD ($)	Series D Preferred Stock[Member]	Series G Preferred Stock[Member]	Series H Preferred Stock[Member]	Series H Two Preferred Stock[Member]	Series J Preferred Stock[Member]	Series K Preferred Stock[Member]	Series AA Preferred Stock[Member]	Common Stock [Member]	Stock Warrants [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Total
Beginning balance, value at Dec. 31, 2019	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 25,496	$ 22,599,177	$ 44,261,105	$ (78,942,277)	$ (12,055,407)
Balance, shares at Dec. 31, 2019	300	80,570	10,000	21	3,458	6,880	7,939	2,549,620
Stock-based compensation										241,769		241,769
Series AA Preferred Stock dividend											(324,586)	(324,586)
Issuance of common stock to settle accrued liabilities								$ 665		127,190		127,855
Issuance of common stock to settle accrued liabilities, shares								66,500
Common stock issued for debt settlement								$ 100		24,900		25,000
Beneficial conversion feature on debt										404,608		404,608
Warrants issued for debt extension									609,143			609,143
Issuance of common stock for interest paid-in-kind								$ 385		60,175		60,560
Issuance of common stock for interest paid-in-kind, shares								38,521
Warrants issued with debt									1,205,010			1,205,010
Net loss											(3,953,885)	(3,953,885)
Ending balance, value at Mar. 31, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 26,646	24,413,330	45,119,747	(83,220,748)	(13,659,933)
Balance, shares at Mar. 31, 2020	300	80,570	10,000	21	3,458	6,880	7,939	2,664,641
Beginning balance, value at Dec. 31, 2019	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 25,496	22,599,177	44,261,105	(78,942,277)	(12,055,407)
Balance, shares at Dec. 31, 2019	300	80,570	10,000	21	3,458	6,880	7,939	2,549,620
Net loss												(11,801,415)
Issuance of common stock for services												$ 87,963
Issuance of common stock for services, shares												25,000
Conversion of debt and interest for common stock												$ 1,800,000
Conversion of debt and interest for common stock, shares												709,788
Ending balance, value at Sep. 30, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 38,392	28,207,172	49,079,182	(91,862,218)	$ (14,536,380)
Balance, shares at Sep. 30, 2020	300	80,570	10,000	21	3,458	6,880	7,983	3,839,256
Beginning balance, value at Mar. 31, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 26,646	24,413,330	45,119,747	(83,220,748)	(13,659,933)
Balance, shares at Mar. 31, 2020	300	80,570	10,000	21	3,458	6,880	7,939	2,664,641
Stock-based compensation										65,341		65,341
Series AA Preferred Stock dividend											(396,970)	(396,970)
Beneficial conversion feature on debt										577,489		577,489
Warrants issued for debt extension									360,602			360,602
Issuance of common stock for interest paid-in-kind, shares								42,510
Warrants issued with debt									1,753,683			1,753,683
Net loss											(4,568,782)	(4,568,782)
Issuance of common stock for services								$ 250		87,713		87,963
Issuance of common stock for services, shares								25,000
Issuance of common stock warrants for interest paid-in-kind								$ 425		98,799		99,224
Issuance of common stock for dividends paid-in-kind								$ 644		176,104		176,748
Issuance of common stock for dividends paid-in-kind, shares								64,388
Conversion of debt and interest for common stock								$ 4,107		1,288,542		1,292,649
Conversion of debt and interest for common stock, shares								410,746
Ending balance, value at Jun. 30, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 32,072	26,527,615	47,413,735	(88,186,500)	(14,211,986)
Balance, shares at Jun. 30, 2020	300	80,570	10,000	21	3,458	6,880	7,939	3,207,285
Stock-based compensation										66,542		66,542
Series AA Preferred Stock dividend											(396,970)	(396,970)
Common stock issued for debt settlement								$ 1,788		347,762		349,550
Common stock issued for debt settlement, shares								178,778
Beneficial conversion feature on debt										371,597		371,597
Issuance of common stock for interest paid-in-kind								$ 460		82,106		82,566
Issuance of common stock for interest paid-in-kind, shares								46,021
Warrants issued with debt									1,302,362			1,302,362
Net loss											(3,278,748)	(3,278,748)
Issuance of common stock for dividends paid-in-kind								$ 232		44,394		44,626
Issuance of common stock for dividends paid-in-kind, shares								23,130
Conversion of debt and interest for common stock								$ 2,990		534,904		537,894
Conversion of debt and interest for common stock, shares								299,042
Conversion of debt into Series AA convertible preferred stock									38,783	71,217		110,000
Conversion of debt into series AA convertible preferred stock, shares							44
Warrants issued for debt settlement									338,412			338,412
Common Stock issued with debt								$ 850		146,925		147,775
Common Stock issued with debt, shares								85,000
Ending balance, value at Sep. 30, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 80	$ 38,392	28,207,172	49,079,182	(91,862,218)	(14,536,380)
Balance, shares at Sep. 30, 2020	300	80,570	10,000	21	3,458	6,880	7,983	3,839,256
Beginning balance, value at Dec. 31, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 81	$ 41,683	29,192,471	50,312,968	(96,465,807)	(16,917,592)
Balance, shares at Dec. 31, 2020	300	80,570	10,000	21	3,458	6,880	8,043	4,168,324
Stock-based compensation										61,237		61,237
Stock option exercise								$ 214		14,559		14,773
Stock option exercise, shares								21,411
Series AA Preferred Stock dividend											(403,215)	(403,215)
Common stock issued for debt settlement, shares	10,000
Series AA Preferred Stock offering									49,884	50,116		100,000
Series AA Preferred Stock offering, shares							40
Beneficial conversion feature on debt										53,777		53,777
Beneficial conversion option on convertible preferred stock										57,884		57,884
Issuance of common stock for interest paid-in-kind								$ 9,224		2,012,556		2,021,780
Issuance of common stock for interest paid-in-kind, shares								922,372
Warrants issued with debt									162,654			162,654
Deemed dividend on convertible preferred stock										(57,884)		(57,884)
Net loss											(6,577,587)	(6,577,587)
Issuance of common stock for services								$ 1,124		237,388		238,512
Issuance of common stock for services, shares								112,400
Issuance of common stock warrants for interest paid-in-kind									600,298			600,298
Conversion of debt and interest for common stock								$ 472		117,528		118,000
Conversion of debt and interest for common stock, shares								47,200
Ending balance, value at Mar. 31, 2021	$ 3	$ 806	$ 100		$ 35	$ 68	$ 81	$ 52,717	30,005,307	52,860,129	(103,446,609)	(20,527,363)
Balance, shares at Mar. 31, 2021	300	80,570	10,000	21	3,458	6,880	8,083	5,271,707
Beginning balance, value at Dec. 31, 2020	$ 3	$ 806	$ 100		$ 35	$ 68	$ 81	$ 41,683	29,192,471	50,312,968	(96,465,807)	$ (16,917,592)
Balance, shares at Dec. 31, 2020	300	80,570	10,000	21	3,458	6,880	8,043	4,168,324
Stock option exercise, shares												208,911
Common stock issued for debt settlement, shares								347,650				56,067
Issuance of common stock for interest paid-in-kind												$ 5,600,000
Net loss												$ (16,273,871)
Issuance of common stock for services, shares												248,200
Conversion of debt and interest for common stock												$ 2,589,990
Conversion of debt and interest for common stock, shares												1,035,996
Ending balance, value at Sep. 30, 2021	$ 3	$ 806	$ 100		$ 35	$ 68	$ 87	$ 83,451	31,607,879	62,307,524	(113,979,213)	$ (19,979,260)
Balance, shares at Sep. 30, 2021	300	80,570	10,000	21	3,458	6,880	8,649	8,345,120
Beginning balance, value at Mar. 31, 2021	$ 3	$ 806	$ 100		$ 35	$ 68	$ 81	$ 52,717	30,005,307	52,860,129	(103,446,609)	(20,527,363)
Balance, shares at Mar. 31, 2021	300	80,570	10,000	21	3,458	6,880	8,083	5,271,707
Stock-based compensation										63,458		63,458
Series AA Preferred Stock dividend											(404,171)	(404,171)
Beneficial conversion feature on debt										513,070		513,070
Issuance of common stock for interest paid-in-kind								$ 7,206		1,425,465		1,432,671
Issuance of common stock for interest paid-in-kind, shares								720,610
Conversion of debt and interest for common stock								$ 925		230,325		231,250
Conversion of debt and interest for common stock, shares								92,500
Warrants issued with debt									906,188			906,188
Stock issued with debt								1,200		111,677		112,877
Stock issued with debt, shares								120,000
Net loss											(4,745,171)	(4,745,171)
Issuance of common stock for dividends paid-in-kind								$ 560		113,738		114,298
Issuance of common stock for dividends paid-in-kind, shares								56,067
Ending balance, value at Jun. 30, 2021	$ 3	$ 806	$ 100		$ 35	$ 68	$ 81	$ 62,608	30,911,495	55,317,862	(108,595,951)	(22,302,893)
Balance, shares at Jun. 30, 2021	300	80,570	10,000	21	3,458	6,880	8,083	6,260,884
Stock-based compensation										95,248		95,248
Issuance of common stock for non-cash warrant exercise								$ 363	(343,201)	342,838
Issuance of common stock for non-cash warrant exercise, shares								36,290
Series AA Preferred Stock dividend											(432,149)	(432,149)
Conversion of debt and interest for common stock								$ 8,963		2,231,777		2,240,740
Conversion of debt and interest for common stock, shares								896,296
Series AA Preferred Stock issued for settlement of liabilities							$ 2		245,635	277,617		523,254
Series AA Preferred Stock issued for settlement of liabilities, shares							200
Series AA Preferred Stock offering							$ 4		459,246	455,750		915,000
Series AA Preferred Stock offering, shares							366
Beneficial conversion feature on debt										664,681		664,681
Beneficial conversion option on convertible preferred stock										815,914		815,914
Issuance of common stock for interest paid-in-kind								$ 7,883		2,146,064		2,153,947
Issuance of common stock for interest paid-in-kind, shares								788,200
Warrants issued with debt									334,704			334,704
Deemed dividend on convertible preferred stock										(815,914)		(815,914)
Stock issued with debt								2,276		436,045		438,321
Stock issued with debt, shares								227,650
Net loss											(4,951,113)	(4,951,113)
Issuance of common stock for services								$ 1,358		339,642		341,000
Issuance of common stock for services, shares								135,800
Issuance of common stock for dividends paid-in-kind												114,298
Ending balance, value at Sep. 30, 2021	$ 3	$ 806	$ 100		$ 35	$ 68	$ 87	$ 83,451	$ 31,607,879	$ 62,307,524	$ (113,979,213)	$ (19,979,260)
Balance, shares at Sep. 30, 2021	300	80,570	10,000	21	3,458	6,880	8,649	8,345,120

Business Overview, Liquidity an

Business Overview, Liquidity and Management Plans	9 Months Ended
	Sep. 30, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Business Overview, Liquidity and Management Plans	1) Business Overview, Liquidity and Management Plans Pressure BioSciences, Inc. (“we”, “our”, “the Company”) develops and sells innovative, broadly enabling, pressure-based platform solutions for the worldwide life sciences industry. Our solutions are based on the unique properties of both constant (i.e., static) and alternating (i.e., pressure cycling technology, or “PCT”) hydrostatic pressure. PCT is a patented enabling technology platform that uses alternating cycles of hydrostatic pressure between ambient and ultra-high levels to control bio-molecular interactions (e.g., cell lysis, biomolecule extraction) safely and reproducibly. Our primary focus has historically been in the development of PCT-based products for biomarker and target discovery, drug design and development, biotherapeutics characterization and quality control, soil & plant biology, forensics, and counter-bioterror applications. Additionally, major new market opportunities have emerged in the use of our pressure-based technology expertise in two new platform technology areas: (1) the use of our recently acquired, patented technology from BaroFold, Inc. for gently controlled disaggregation and refolding of biotherapeutic proteins (the “BaroFold” technology) to allow entry into the bio-pharma contract services sector, and (2) the use of our recently-patented, scalable, high-efficiency, pressure-based Ultra Shear Technology (“UST”) platform to (i) create stable nanoemulsions of otherwise immiscible fluids (e.g., oils and water) for greatly improved cost-effectiveness, high bioavailability, safer and improved sensory experience in products spanning pharmaceuticals, nutraceuticals, cosmeceuticals, personal care products, agrochemicals, food/beverage and many industrial products and to (ii) prepare higher quality, homogenized, extended shelf-life or room-temperature stable low-acid liquid foods that cannot be effectively preserved using existing non-thermal technologies.

Going Concern

Going Concern	9 Months Ended
	Sep. 30, 2021
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Going Concern	2) Going Concern The accompanying financial statements have been prepared assuming that the Company will continue as a going concern, which contemplates the realization of assets and the liquidation of liabilities in the normal course of business. However, we have experienced losses from operations and negative cash flows from operations with respect to our pressure cycling technology business since our inception. As of September 30, 2021, we do not have adequate working capital resources to satisfy our current liabilities and as a result, there is substantial doubt regarding our ability to continue as a going concern. We have been successful in raising debt and equity capital in the past and as described in Notes 5 and 6. In addition we raised debt and equity capital after September 30, 2021 as described in Note 7. We have financing efforts in place to continue to raise cash through debt and equity offerings. Although we have successfully completed financings and reduced expenses in the past, we cannot assure you that our plans to address these matters in the future will be successful. These financial statements do not include any adjustments that might result from this uncertainty.

Summary of Significant Accounti

Summary of Significant Accounting Policies	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	3) Summary of Significant Accounting Policies Basis of Presentation The unaudited interim financial statements of Pressure BioSciences, Inc. and its consolidated subsidiaries (collectively, the “Company”) included herein have been prepared by the Company in accordance with the instructions to Form 10-Q and the rules and regulations of the U.S. Securities and Exchange Commission. Under these rules and regulations, some information and footnote disclosures normally included in financial statements prepared under accounting principles generally accepted in the United States of America have been shortened or omitted. Management believes that all adjustments necessary for a fair statement of the financial position and the results of operations for the periods shown have been made. All adjustments are normal and recurring. These financial statements should be read together with the Company’s audited financial statements included in its Form 10-K for the fiscal year ended December 31, 2020. Use of Estimates The Company’s consolidated financial statements and accompanying notes are prepared in accordance with accounting principles generally accepted in the United States of America, which require the use of estimates, judgements and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the periods presented. Global concerns about the COVID-19 pandemic have adversely affected, and we expect will continue to adversely affect, our business, financial condition and results of operations including the estimates and assumptions made by management. Significant estimates and assumptions include valuations of share-based awards, investments in equity securities and intangible asset impairment. Actual results could differ from the estimates, and such differences may be material to the Company’s consolidated financial statements. Principles of Consolidation The consolidated financial statements include the accounts of Pressure BioSciences, Inc., and its wholly owned subsidiaries PBI BioSeq, Inc and PBI Agrochem Inc. All intercompany accounts and transactions have been eliminated in consolidation. Revenue Recognition We recognize revenue in accordance with FASB ASC 606, Revenue from Contracts with Customers, ASC 340-40, Other Assets and Deferred Costs—Contracts with Customers We identify a performance obligation as distinct if both the following criteria are true: the customer can benefit from the good or service either on its own or together with other resources that are readily available to the customer and the entity’s promise to transfer the good or service to the customer is separately identifiable from other promises in the contract. Determining the standalone selling price (“SSP”) and allocation of consideration from a contract to the individual performance obligations, and the appropriate timing of revenue recognition, is the result of significant qualitative and quantitative judgments. Management considers a variety of factors such as historical sales, usage rates, costs, and expected margin, which may vary over time depending upon the unique facts and circumstances related to each performance obligation in making these estimates. While changes in the allocation of the SSP between performance obligations will not affect the amount of total revenue recognized for a particular contract, any material changes could impact the timing of revenue recognition, which would have a material effect on our financial position and result of operations. This is because the contract consideration is allocated to each performance obligation, delivered or undelivered, at the inception of the contract based on the SSP of each distinct performance obligation. Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by the Company from a customer, are excluded from revenue. Shipping and handling costs associated with outbound freight after control over a product has transferred to a customer are accounted for as a fulfillment cost and are in included in cost of revenues as consistent with treatment in prior periods. Our current Barocycler® instruments require a basic level of instrumentation expertise to set-up for initial operation. To support a favorable first experience for our customers, upon customer request, and for an additional fee, we will send a highly trained technical representative to the customer site to install Barocyclers® that we sell, lease, or rent through our domestic sales force. The installation process includes uncrating and setting up the instrument, followed by introductory user training. Our sales arrangements do not provide our customers with a right of return. Any shipping costs billed to customers are recognized as revenue. The majority of our instrument and consumable contracts contain pricing that is based on the market price for the product at the time of delivery. Our obligations to deliver product volumes are typically satisfied and revenue is recognized when control of the product transfers to our customers. Concurrent with the transfer of control, we typically receive the right to payment for the shipped product and the customer has significant risks and rewards of ownership of the product. Payment terms require customers to pay shortly after delivery and do not contain significant financing components. Revenue from scientific services customers is recognized upon completion of each stage of service as defined in service agreements. We apply ASC 845, “Accounting for Non-Monetary Transactions”, to account for products and services sold through non-cash transactions based on the fair values of the products and services involved, where such values can be determined. Non-cash exchanges would require revenue to be recognized at recorded cost or carrying value of the assets or services sold if any of the following conditions apply: a) The fair value of the asset or service involved is not determinable. b) The transaction is an exchange of a product or property held for sale in the ordinary course of business for a product or property to be sold in the same line of business to facilitate sales to customers other than the parties to the exchange. c) The transaction lacks commercial substance. We recognize revenue for non-cash transactions at recorded cost or carrying value of the assets or services sold. We account for lease agreements of our instruments in accordance with ASC 842, Leases. We record revenue over the life of the lease term, and we record depreciation expense on a straight-line basis over the thirty-six-month estimated useful life of the Barocycler® instrument. The depreciation expense associated with assets under lease agreement is included in the “Cost of PCT products and services” line item in our accompanying consolidated statements of operations. Many of our lease and rental agreements allow the lessee to purchase the instrument at any point during the term of the agreement with partial or full credit for payments previously made. We pay all maintenance costs associated with the instrument during the term of the leases. Deferred revenue represents amounts received from service contracts for which the related revenues have not been recognized because one or more of the revenue recognition criteria have not been met. Revenue from service contracts is recorded ratably over the length of the contract. Disaggregation of revenue In the following table, revenue is disaggregated by primary geographical market, major product line, and timing of revenue recognition. Schedule of Disaggregation of Revenue In thousands of US dollars ($) Three Months Ended September 30, Nine Months Ended September 30, Primary geographical markets 2021 2020 2021 2020 North America $ 351 $ 387 $ 1,036 $ 694 Europe 57 2 244 6 Asia 110 145 407 356 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Major products/services lines 2021 2020 2021 2020 Hardware $ 276 $ 313 $ 989 $ 569 Consumables 45 49 191 156 Contract research services 100 84 242 128 Sample preparation accessories 39 40 108 98 Technical support/extended service contracts 26 33 84 69 Shipping and handling 11 11 46 26 Other 21 4 27 10 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Timing of revenue recognition 2021 2020 2021 2020 Products transferred at a point in time $ 392 $ 417 $ 1,361 $ 859 Services transferred over time 126 117 326 197 $ 518 $ 534 $ 1,687 $ 1,056 Contract balances Schedule of Contract Balances In thousands of US dollars ($) September 30, 2021 December 31, 2020 Receivables, which are included in ‘Accounts Receivable’ $ 539 $ 131 Contract liabilities (deferred revenue) 53 67 Transaction price allocated to the remaining performance obligations. The following table includes estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) at the end of the reporting period. Schedule of Future Related to Performance Obligations In thousands of US dollars ($) 2021 2022 Total Extended warranty service $ 44 $ 9 $ 53 All consideration from contracts with customers is included in the amounts presented above. Contract Costs The Company recognizes the incremental costs of obtaining contracts as an expense when incurred if the amortization period of the assets that the Company otherwise would have recognized is one year or less. These costs are included in selling, general, and administrative expenses. The costs to obtain a contract are recorded immediately in the period when the revenue is recognized either upon shipment or installation. The costs to obtain a service contract are considered immaterial when spread over the life of the contract so the Company records the costs immediately upon billing. Concentrations Credit Risk Our financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash, cash equivalents, and trade receivables. We have cash investment policies which, among other things, limit investments to investment-grade securities. We perform ongoing credit evaluations of our customers, and the risk with respect to trade receivables is further mitigated by the fact that many of our customers are government institutions, large pharmaceutical and biotechnology companies, and academic laboratories. The following table illustrates the level of concentration as a percentage of total revenues during the three and nine months ended September 30, 2021 and 2020. Schedule of Customer Concentration Risk Percentage For the Three Months Ended September 30, 2021 2020 Top Five Customers 56 % 59 % Federal Agencies 3 % 2 % For the Nine Months Ended September 30, 2021 2020 Top Five Customers 42 % 36 % Federal Agencies 6 % 3 % The following table illustrates the level of concentration as a percentage of net accounts receivable balance as of September 30, 2021 and December 31, 2020. The Top Five Customers category may include federal agency receivable balances if applicable. September 30, 2021 December 31, 2020 Top Five Customers 63 % 89 % Federal Agencies 2 % 10 % Product Supply In recent years we utilized a contract assembler for our Barocycler® 2320EXT. They provided us with precision manufacturing services that included management support services to meet our specific application and operational requirements. Among the services provided to us were: ● CNC Machining ● Contract Assembly & Kitting ● Component and Subassembly Design ● Inventory Management ● ISO certification Beginning in July 2021, we brought the assembly of our Barocycler 2320EXT instruments in-house. This became necessary when our independent contract assembler (CBM Industries) informed us that they were about to need 100% of their assembly space for one of their customers, who was in fact one of the largest life science instrument manufacturers in the U.S. We worked with our notified body to gain approval to use both the CE and CSA marks on the instrument, which we received during Q3 2021. Until further notice, we expect to continue to assemble our Barocycler 2320EXT instrument at our Easton MA location. We currently manufacture and assemble the Barocycler®, HUB440, HUB880, the SHREDDER SG3, and most of our consumables at our South Easton, MA facility. We will regularly reassess the tradeoffs between in-house assembly versus the benefits of outsourced relationships for of the entire Barocycler® product line, and future instruments. Investment in Equity Securities As of September 30, 2021, we held 100,250 We account for this investment in accordance with ASC 320 “Investments — Debt and Equity Securities”. ASC 320 requires equity investments with readily determinable fair values to be measured at fair value with changes in fair value recognized in net income. As of September 30, 2021, our consolidated balance sheet reflected the fair value, determined on a recurring basis based on Level 1 inputs of our investment in Nexity, to be $ 112,550 . We recorded $ 404,451 as an unrealized loss during the nine months ended September 30, 2021 for changes in market value. Computation of Loss per Share Basic loss per share is computed by dividing loss available to common shareholders by the weighted average number of common shares outstanding. Diluted loss per share is computed by dividing loss available to common shareholders by the weighted average number of common shares outstanding plus additional common shares that would have been outstanding if dilutive potential common shares had been issued. For purposes of this calculation, convertible preferred stock, common stock dividends, and warrants and options to acquire common stock, are all considered common stock equivalents in periods in which they have a dilutive effect and are excluded from this calculation in periods in which these are anti-dilutive to our net loss. The following table illustrates our computation of loss per share for the three and nine months ended September 30, 2021 and 2020: Schedule of Computation of Loss Per Share 2021 2020 2021 2020 For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Numerator: Net loss attributable to common stockholders $ (6,199,176 ) $ (3,675,718 ) $ (18,387,204 ) $ (12,919,941 ) Denominator for basic and diluted loss per share: Weighted average common stock shares outstanding 7,561,728 3,612,958 6,083,017 3,059,095 Loss per common share – basic and diluted $ (0.82 ) $ (1.02 ) $ (3.02 ) $ (4.22 ) The following table presents securities that could potentially dilute basic loss per share in the future. For all periods presented, the potentially dilutive securities were not included in the computation of diluted loss per share because these securities would have been anti-dilutive to our net loss. The Series D Convertible Preferred Stock, Series G Convertible Preferred Stock, Series H and H2 Convertible Preferred Stock, Series J Convertible Preferred Stock, Series K Convertible Preferred Stock, and Series AA Convertible Preferred Stock are presented below as if they were converted into common shares according to the conversion terms. Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share As of September 30, 2021 2020 Stock options 1,342,490 1,392,370 Convertible debt 5,330,318 4,610,868 Common stock warrants 16,265,570 13,831,497 Convertible preferred stock: Series D Convertible Preferred Stock 25,000 25,000 Series G Convertible Preferred Stock 26,857 26,857 Series H Convertible Preferred Stock 33,334 33,334 Series H2 Convertible Preferred Stock 70,000 70,000 Series J Convertible Preferred Stock 115,267 115,267 Series K Convertible Preferred Stock 229,334 229,334 Series AA Convertible Preferred Stock 8,649,000 7,983,000 32,087,170 28,317,527 Accounting for Stock-Based Compensation Expense We maintain equity compensation plans under which incentive stock options and non-qualified stock options are granted to employees, independent members of our Board of Directors and outside consultants. We recognize stock-based compensation expense over the requisite service period using the Black-Scholes formula to estimate the fair value of the stock options on the date of grant. Determining Fair Value of Stock Option Grants Valuation and Amortization Method - The fair value of each option award is estimated on the date of grant using the Black-Scholes pricing model based on certain assumptions. The estimated fair value of employee stock options is amortized to expense using the straight-line method over the vesting period. Expected Term - The Company uses the simplified calculation of expected life, as the Company does not currently have sufficient historical exercise data on which to base an estimate of expected term. Using this method, the expected term is determined using the average of the vesting period and the contractual life of the stock options granted. Expected Volatility - Expected volatility is based on the Company’s historical stock volatility data over the expected term of the award. Risk-Free Interest Rate - The Company bases the risk-free interest rate used in the Black-Scholes valuation method on the implied yield currently available on U.S. Treasury zero-coupon issues with an equivalent remaining term. Forfeitures - The Company records stock-based compensation expense only for those awards that are expected to vest. The Company estimated a forfeiture rate of 5% for awards granted based on historical experience and future expectations of options vesting. The Company used this historical rate as our assumption in calculating future stock-based compensation expense. The Company recognized stock-based compensation expense of $ 95,248 and $ 66,542 for the three months ended September 30, 2021 and 2020, respectively. The Company recognized stock-based compensation expense of $ 219,943 and $ 373,652 for the nine months ended September 30, 2021 and 2020, respectively. The following table summarizes the effect of this stock-based compensation expense within each of the line items of our costs and expenses within our Consolidated Statements of Operations: Schedule of Stock Based Compensation Expense For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Cost of sales $ 8,664 $ 5,164 $ 18,824 $ 18,227 Research and development 43,031 26,423 95,384 91,386 Selling and marketing 7,168 6,428 17,650 26,722 General and administrative 36,385 28,527 88,085 237,317 Total stock-based compensation expense $ 95,248 $ 66,542 $ 219,943 $ 373,652 Fair Value of Financial Instruments Due to their short maturities, the carrying amounts for cash and cash equivalents, accounts receivable, accounts payable, accrued expenses and debt approximate their fair value. The carrying amount of long-term debt approximates fair value due to interest rates that approximate prevailing market rates. Fair Value Measurements The Company follows the guidance of FASB ASC Topic 820, “ Fair Value Measurements and Disclosures The Company generally defines fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date (exit price). The Company uses a three-tier fair value hierarchy, which classifies the inputs used in measuring fair values. These tiers include: Level 1, defined as observable inputs such as quoted prices for identical instruments in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring the Company to develop its own assumptions. A slight change in an unobservable input like volatility could have a significant impact on fair value measurement. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company has determined that its financial assets are classified within Level 1 in the fair value hierarchy. The development of the unobservable inputs for Level 3 fair value measurements and fair value calculations are the responsibility of the Company’s management. The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of September 30, 2021: Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis Fair value measurements at September 30, 2021 using: September 30, 2021 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities $ 112,550 $ 112,550 Total Financial Assets $ 112,550 $ 112,550 $ - $ - The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of December 31, 2020: Fair value measurements at December 31, 2020 using: December 31, 2020 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities 517,001 517,001 Total Financial Assets $ 517,001 $ 517,001 $ - $ -

Commitments and Contingencies

Commitments and Contingencies	9 Months Ended
	Sep. 30, 2021
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	4) Commitments and Contingencies Operating Leases The Company accounts for its leases under ASC 842. The Company has elected to apply the short-term lease exception to leases of one year or less. Our corporate office is currently located at 14 Norfolk Avenue, South Easton, Massachusetts 02375. We are currently paying $ 6,950 December 31, 2021 We extended our lease for our space in Medford, MA (the “Medford Lease”) from December 30, 2020 to December 30, 2023. The lease requires monthly payments of $ 7,282 The lease shall be automatically extended for additional three years unless either party terminates at least six months prior to the expiration of the current lease term. The Company accounted for the lease extension of our Medford Lease as a lease modification under ASC 842. At the effective date of modification, the Company recorded an adjustment to the right-of-use asset and lease liability in the amount of $ 221,432 12 Following is a schedule by years of future minimum rental payments required under operating leases with initial or remaining non-cancelable lease terms as of September 30, 2021: Schedule of Future Minimum Rental Payments Required Under Operating Leases 2021 2021 $ 42,696 2022 87,383 2023 87,383 Total minimum payments required $ 217,462 Target Discovery, Inc. In the nine months ended September 30, 2021, the Company incurred $ 44,600 in fees with Target Discovery, Inc. for the use of their facilities and other services.

Convertible Debt and Other Debt

Convertible Debt and Other Debt	9 Months Ended
	Sep. 30, 2021
Debt Disclosure [Abstract]
Convertible Debt and Other Debt	5) Convertible Debt and Other Debt Convertible Debt On various dates during the nine months ended September 30, 2021, the Company issued convertible notes for a total of $ 5,857,375 which contained varied terms and conditions as follows: a) 6 - 12 month maturity date; b) interest rates of 10 - 18 %; c) convertible to the Company’s common stock at issuance at a fixed rate of $ 2.50 or at variable conversion rates upon the Company’s up-listing to NASDAQ or NYSE or an event of default. These notes were issued with either shares of common stock or warrants to purchase common stock that were fair valued at issuance date. The aggregate relative fair value of the shares of common stock and warrants issued with the notes of $ 1,954,744 was recorded as a debt discount to be amortized over the term of the notes. We then computed the effective conversion price of the notes, and recorded a $ 1,231,528 beneficial conversion feature as a debt discount to be amortized over the term of the notes. We also evaluated the convertible notes for derivative liability treatment and determined that the notes did not qualify for derivative accounting treatment at September 30, 2021. The specific terms of the convertible notes and outstanding balances as of September 30, 2021 are listed in the tables below. Schedule of Convertible Debts and Outstanding Balances Inception Date Term Loan Amount Outstanding balance with OID Original Issue Discount (OID) Interest Rate Conversion Price Deferred Finance Fees Discount for conversion feature and warrants/ shares May 17, 2018 (1) (2) 12 months $ 380,000 $ 166,703 $ 15,200 8 % $ 2.50 $ 15,200 $ 332,407 January 3, 2019 (1) (4) 6 months $ 50,000 $ 50,000 $ 2,500 24 % $ 7.50 $ 2,500 $ - June 4, 2019 (1) (2) 9 months $ 500,000 $ 302,484 $ - 8 % $ 2.50 $ 40,500 $ 70,631 July 19, 2019 (1) (2) 12 months $ 115,000 $ 115,000 $ - 4 % $ 2.50 $ 5,750 $ 15,460 September 27, 2019 12 months $ 78,750 $ 78,750 $ - 4 % $ 2.50 $ 3,750 $ 13,759 October 24,2019 12 months $ 78,750 $ 78,750 $ - 4 % $ 2.50 $ 3,750 $ - 11/15/2019 (1) 12 months $ 385,000 $ 320,000 $ 35,000 10 % $ 2.50 $ 35,000 $ 90,917 1/2/2020 12 months $ 330,000 $ 330,000 $ 30,000 10 % $ 2.50 $ 30,000 $ 91,606 1/24/2020 12 months $ 247,500 $ 247,500 $ 22,500 10 % $ 2.50 $ 22,500 $ 89,707 1/29/2020 (1) 12 months $ 363,000 $ 363,000 $ 33,000 10 % $ 2.50 $ 33,000 $ 297,000 2/12/2020 12 months $ 275,000 $ 275,000 $ 25,000 10 % $ 2.50 $ 25,000 $ 225,000 2/19/2020 (1) 12 months $ 165,000 $ 165,000 $ 15,000 10 % $ 2.50 $ 15,000 $ 135,000 3/11/2020 12 months $ 330,000 $ 330,000 $ 30,000 10 % $ 2.50 $ 30,000 $ 232,810 3/13/2020 12 months $ 165,000 $ 165,000 $ 15,000 10 % $ 2.50 $ 15,000 $ 60,705 3/26/2020 12 months $ 111,100 $ 111,100 $ 10,100 10 % $ 2.50 $ 10,100 $ 90,900 4/8/2020 12 months $ 276,100 $ 276,100 $ 25,100 10 % $ 2.50 $ 25,000 $ 221,654 4/17/2020 12 months $ 143,750 $ 143,750 $ 18,750 10 % $ 2.50 $ - $ 96,208 4/30/2020 12 months $ 546,250 $ 546,250 $ 71,250 10 % $ 2.50 $ 47,500 $ 427,500 5/6/2020 12 months $ 460,000 $ 460,000 $ 60,000 10 % $ 2.50 $ 40,000 $ 360,000 5/18/2020 12 months $ 546,250 $ 221,250 $ 46,250 10 % $ 2.50 $ 35,500 $ 439,500 6/2/2020 12 months $ 902,750 $ 652,750 $ 92,750 10 % $ 2.50 $ 58,900 $ 708,500 6/12/2020 12 months $ 57,500 $ 57,500 $ 7,500 10 % $ 2.50 $ 5,000 $ 45,000 6/22/2020 12 months $ 138,000 $ 138,000 $ 18,000 10 % $ 2.50 $ 12,000 $ 108,000 July 7, 2020 12 months $ 586,500 $ 586,500 $ 76,500 10 % $ 2.50 $ 51,000 $ 400,234 July 17, 2020 12 months $ 362,250 $ 362,250 $ 47,250 10 % $ 2.50 $ 31,500 $ 185,698 July 29, 2020 12 months $ 345,000 $ 345,000 $ 45,000 10 % $ 2.50 $ 30,000 $ 241,245 July 21, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 24,875 August 14, 2020 12 months $ 762,450 $ 462,450 $ 69,450 10 % $ 2.50 $ 66,300 $ 580,124 September 10, 2020 12 months $ 391,000 $ 391,000 $ 51,000 10 % $ 2.50 $ 34,000 $ 231,043 September 21, 2020 (1) (5) 12 months $ 345,000 $ 345,000 $ 45,000 10 % $ 2.50 $ 30,000 $ 66,375 September 23, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 20,500 September 25, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ - $ 19,125 December 3, 2020 12 months $ 299,000 $ 299,000 $ 39,000 10 % $ 2.50 $ 26,000 $ 197,882 October 22, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 18,875 January 5, 2021 (1) 6 months $ 575,000 $ 475,000 $ 75,000 18 % $ 2.50 $ - $ - February 17, 2021 12 months $ 230,000 $ 230,000 $ 30,000 10 % $ 2.50 $ 20,000 $ 180,000 March 23, 2021 12 months $ 55,000 $ 55,000 $ 5,000 10 % $ 2.50 $ - $ 36,431 May 24, 2021 6 months $ 54,625 $ 54,625 $ 7,125 12 % $ 2.50 $ - $ - May 6, 2021 12 months $ 402,500 $ 402,500 $ 52,500 10 % $ 2.50 $ 35,000 $ 312,551 June 17, 2021 12 months $ 230,000 $ 230,000 $ 30,000 10 % $ 2.50 $ 20,000 $ 144,760 June 25, 2021 12 months $ 977,500 $ 977,500 $ 127,500 10 % $ 2.50 $ - $ 773,802 May 20, 2021 12 months $ 180,000 $ 30,000 $ 30,000 10 % $ 2.50 $ 15,000 $ 25,824 June 3, 2021 12 months $ 50,000 $ 50,000 $ 1,500 12 % $ 2.50 $ - $ 7,948 June 28, 2021 12 months $ 350,000 $ 350,000 $ 35,000 12 % (6 ) $ 22,750 $ 267,250 July 3, 2021 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 90,000 July 1, 2021 6 months $ 260,000 $ 260,000 $ 10,000 12 % $ 2.50 $ - $ 89,640 July 6, 2021 6 months $ 125,000 $ 125,000 $ - 12 % $ 2.50 $ - $ 42,031 July 6, 2021 6 months $ 125,000 $ 125,000 $ - 12 % $ 2.50 $ - $ 42,031 July 15, 2021 6 months $ 100,000 $ 100,000 $ 5,000 12 % (7 ) $ - $ 57,716 July 16, 2021 6 months $ 50,000 $ 50,000 $ 2,000 12 % $ 3.00 $ - $ 40,806 July 16, 2021 6 months $ 306,250 $ 306,250 $ 56,250 (3 ) (8 ) $ 22,500 $ 227,500 July 16, 2021 6 months $ 306,250 $ 306,250 $ 56,250 (3 ) (8 ) $ 12,500 $ 237,500 July 16, 2021 6 months $ 122,500 $ 122,500 $ 22,500 (3 ) (8 ) $ 5,000 $ 95,000 August 31, 2021 6 months $ 189,750 $ 189,750 $ 24,750 10 % (9 ) $ 16,500 $ 148,500 Sept. 8, 2021 8 months $ 78,000 $ 78,000 $ 3,000 12 % (7 ) $ - $ 40,449 Sept. 10, 2021 8 months $ 100,000 $ 100,000 $ 4,000 12 % (7 ) $ - $ 43,520 Sept. 15, 2021 8 months $ 250,000 $ 250,000 $ 12,500 12 % (7 ) $ - $ 108,801 Sept. 16, 2021 8 months $ 250,000 $ 250,000 $ 12,500 12 % (7 ) $ - $ 112,337 Sept. 24, 2021 8 months $ 125,000 $ 125,000 $ 6,250 12 % $ (7 ) $ - $ 61,876 Sept. 15, 2021 6 months $ 250,000 $ 250,000 $ 37,500 12 % $ (7 ) $ 30,000 $ - $ 14,452,462 $ 1,667,225 $ 1,019,000 $ 9,324,513 (1) The Note is past due. The Company and the lender are negotiating in good faith to extend the loan. (2) In recent quarters the Company and lenders have entered into Standstill and Forbearance Agreements (as described below). (3) Note is secured by the assets of the Company’s subsidiary, PBI Agrochem, Inc. and interest rate is 18.4% OID. (4) During the year ended December 31, 2020 the Company entered into a Rate Modification Agreement with this lender. In this agreement the lender agreed to reduce their interest rate and were granted the right to convert loans using a variable conversion price if more than one other variable rate lender converted at a variable rate. (5) The Company has agreed to issue shares of its common stock to lenders if their notes are not repaid by a defined date. (6) Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $ 2.50 90 (7) Notes are convertible before maturity at $ 2.50 (8) Notes can be converted at the lesser of $ 2.50 25 (9) Conversion price of this note is $ 2.50 As of September 30, 2021 one lender holds approximately $ 9.4 million of the $ 14.5 million convertible notes outstanding. For the nine months ended September 30, 2021, the Company recognized amortization expense related to the debt discounts indicated above of $ 5,260,151 . The unamortized debt discounts as of September 30, 2021 related to the convertible debentures and other convertible notes amounted to $ 2,692,163 . Standstill and Forbearance Agreements The Company has entered into Standstill and Forbearance Agreements with lenders who hold variable-rate convertible notes with a total principal as of June 30, 2021 of $ 1.57 million. Pursuant to the Standstill and Forbearance Agreements, the lenders agreed to not convert any portion of their notes into shares of common stock at a variable rate until March 31, 2021 for convertible notes with a principal balance of $ 469,000 and until April 16, 2021 for convertible notes with a principal balance of $ 1.1 million. During the third quarter of 2021, the Company settled three lenders (five Notes) with total principal of $ 827,500 , leaving two final lenders (five Notes) with total principal of $ 741,500 For the nine months ended September 30, 2021, the Company incurred interest, penalties, and fees of approximately $ 1.25 million in connection with Standstill and Forbearance Agreements. Convertible Loan Modifications and Extinguishments We refinanced certain convertible loans during the nine months ended September 30, 2021 at substantially the same terms for extensions ranging over a period of three to six months. We amortized any remaining unamortized debt discount as of the modification date over the remaining, extended term of the new loans. We applied ASC 470 of modification accounting to the debt instruments which were modified during the quarter or those settled with new notes issued concurrently for the same amounts but different maturity dates. The terms such as the interest rate, prepayment penalties, and default rates will be the same over the new extensions. According to ASC 470, an exchange of debt instruments between or a modification of a debt instrument by a debtor and a creditor in a nontroubled debt situation is deemed to have been accomplished with debt instruments that are substantially different if the present value of the cash flows under the terms of the new debt instrument is at least 10 percent different from the present value of the remaining cash flows under the terms of the original instrument. If the terms of a debt instrument are changed or modified and the cash flow effect on a present value basis is less than 10 percent, the debt instruments are not considered to be substantially different and will be accounted for as modifications. The cash flows of new debt exceeded 10 % of the remaining cash flows of the original debt on several loans. During the nine months ended September 30, 2021 we recorded losses on extinguishment of liabilities of approximately $ 1.9 million by calculating the difference of the fair value of the new debt and the carrying value of the old debt. The following table provides a summary of the changes in convertible debt, net of unamortized discounts, during 2021: Summary of Changes in Convertible Debt and Revolving Note Payable, Net of Unamortized Discounts 2021 Balance at January 1, $ 7,545,670 Issuance of convertible debt, face value 5,857,375 Deferred financing cost (802,875 ) Beneficial conversion feature on convertible note (1,231,528 ) Debt discount from shares and warrants issued with debt (1,954,744 ) Payments (1,608,295 ) Conversion of debt into equity (1,305,455 ) Accretion of interest and amortization of debt discount to interest expense 5,260,151 Balance at September 30, 11,760,299 Less: current portion 11,760,299 Convertible debt, long-term portion $ – Other Notes On September 9, 2019 and February 28, 2020 we received a total of $ 966,500 463,500 150,000 five 3.50 275,000 185,660 691,500 On October 1, 2019, the Company and the holder of the $ 170,000 1,200 10 On October 11, 2019 we received a non-convertible loan with a one -month term and a 2 % interest charge for $ 25,000 from a private investor. During the quarter ended September 30, 2021 the Company issued 17 17,000 five 3.50 Merchant Agreements We have signed various Merchant Agreements which are secured by second position rights to all customer receipts until the loan has been repaid in full and subject to interest rates of 9.3 % - 14 % per month. As illustrated in the following table, under the terms of these agreements, we received the disclosed Purchase Price and agreed to repay the disclosed Purchase Amount, which is collected by the Merchant lenders at the disclosed Daily Payment Rate. The Company’s Chief Executive Officer is personally guaranteeing the performance of the merchant loans. The following table shows our Merchant Agreements as of September 30, 2021: Schedule of Merchant Agreements Inception Date Purchase Price Purchased Amount Outstanding Balance Daily Payment Rate Deferred Finance Fees March 26, 2021 240,000 330,960 20,775 2,364 - May 3, 2021 200,000 275,800 51,470 1,970 5,000 June 2, 2021 135,000 186,165 61,657 1,400 1,350 July 6, 2021 125,000 166,250 76,416 1,279 2,500 $ 700,000 $ 959,175 $ 210,318 $ 7,013 $ 8,850 The following table shows our Merchant Agreements as of December 31, 2020: Inception Date Purchase Price Purchased Amount Outstanding Balance Daily Payment Rate Deferred Finance Fees November 5, 2020 $ 200,000 $ 275,800 $ 163,955 1,724 $ - November 19, 2020 100,000 137,900 85,013 985 - $ 300,000 $ 413,700 $ 248,968 $ 2,709 $ - We have accounted for the Merchant Agreements as loans under ASC 860 because while we provided rights to current and future receipts, we still had control over the receipts. The difference between the Purchase Amount and the Purchase Price is imputed interest that is recorded as interest expense when paid each day. Related Party Notes During the nine months ended September 30, 2021, we received short-term non-convertible loans of $ 194,600 from related parties, which bear interest ranging from 10 % to 15 % and are due upon demand. In this time, we repaid 2021 and prior loans for $ 256,600 in cash and issued 69.5 69,450 five 3.50 66,000 107,625 Long term debt During the nine months ended September 30, 2021, the Company borrowed $ 367,038 through a COVID-19 Payroll Protection Program (or “PPP”) that was sponsored by the United States and administered by the Small Business Administration (the “SBA”). The PPP loan has a 1 % interest rate and a five -year term. During this period, a prior PPP loan to the Company, borrowed in 2020 ($ 367,039 ) was forgiven by the SBA. This gain was reported in losses on extinguishment of liabilities on the consolidated statements of operations. The Company also entered into another COVID-19 government loan in 2020, the Economic Injury Disaster Loan (or “EIDL”) . The Company’s EIDL loan, $ 150,000 , accrues interest at 3.75 % and requires monthly payments of $ 731 for principal and interest beginning in June 2021. The balance of the principal will be due in 30 years . In connection with the EIDL loan the Company entered into a security agreement with the SBA, whereby the Company granted the SBA a security interest in all of the Company’s right, title and interest in all of the Company’s assets.

Stockholders_ Deficit

Stockholders’ Deficit	9 Months Ended
	Sep. 30, 2021
Equity [Abstract]
Stockholders’ Deficit	6) Stockholders’ Deficit Preferred Stock We are authorized to issue 1,000,000 0.01 1,000,000 1) 20,000 Junior A 2) 313,960 Series A 3) 279,256 Series B 4) 88,098 Series C 5) 850 Series D 6) 500 (“Series E”) 7) 240,000 Series G 8) 10,000 Series H 9) 21 Series H2 10) 6,250 Series J 11) 15,000 Series K 12) 10,000 Series AA As of September 30, 2021, there were no During the nine months ended September 30, 2021, the Company entered into Securities Purchase Agreements with accredited investors pursuant to which the Company sold an aggregate of 406 shares of Series AA Convertible Preferred Stock, each preferred share convertible into 1,000 shares of the Company’s common stock, par value $ 0.01 per share, for an aggregate Purchase price of $ 1,015,000 . We issued to the investors warrants to purchase an aggregate 406,000 shares of common stock with an exercise price of $ 3.50 per share. The Company did not incur any placement agent fees for these transactions. Stock Options and Warrants At the Company’s December 12, 2013 Special Meeting, the shareholders approved the 2013 Equity Incentive Plan (the “2013 Plan”) pursuant to which 3,000,000 1,342,490 As of September 30, 2021, total unrecognized compensation cost related to the unvested stock-based awards was $ 178,801 , which is expected to be recognized over weighted average period of 1.43 years. The aggregate intrinsic value associated with the options outstanding and exercisable, and the aggregate intrinsic value associated with the warrants outstanding and exercisable as of September 30, 2021, based on the September 30, 2021 closing stock price of $ 2.50 , was $ 1,897,066 . The following table summarizes information concerning options and warrants outstanding and exercisable: Schedule of Concerning Options and Warrants Outstanding and Exercisable Stock Options Warrants Weighted Weighted Average Average Shares price Shares price Shares Total Balance outstanding, December 31, 2020 1,355,901 $ 0.69 14,434,702 $ 3.50 15,790,603 15,302,830 Granted 24,000 2.17 2,164,366 3.59 2,188,366 - Exercised (21,411 ) 0.69 (187,500 ) 3.50 (208,911 ) - Expired/forfeited (16,000 ) 0.69 (145,998 ) $ 3.50 (161,998 ) - Balance outstanding, September 30, 2021 1,342,490 $ 0.72 16,265,570 $ 3.50 17,608,060 17,313,673 In the nine months ended September 30, 2021 the Company issued 24,000 stock options to an employee ($ 49,135 fair value, $ 2.17 exercise price, three -year vesting term and ten -year expiration term). As of September 30, 2021, the 1,342,490 stock options outstanding have a $ 0.72 weighted average exercise price and 7.96 years weighted average remaining term. Of these options, 1,048,103 are currently exercisable. Common Stock and Warrant Issuances As profiled in the following table, for five loans we are obligated to issue common stock if not paid by defined dates. Schedule of Loans Obligated to Issue Shares Loan Issuance Loan Shares Defined Defined Loan Date Principal Issuable Date Frequency Loan 1 July 21, 2020 $ 115,000 5,000 September 30, 2020 Monthly Loan 2 September 21, 2020 $ 345,000 12,500 November 16, 2020 Weekly Loan 3 September 23, 2020 $ 115,000 12,500 December 1, 2020 Weekly Loan 4 September 25, 2020 $ 115,000 12,500 December 1, 2020 Weekly Loan 5 October 22, 2020 $ 115,000 12,500 December 1, 2020 Weekly For the nine-month period ended September 30,2021 the Company is obligated to issue 1,244,286 For our loan dated December 23, 2020, we are obligated to issue 100,000 warrants if the loan is not repaid before January 23, 2021 and an additional 10,000 shares of common stock and 100,000 warrants if the loan is not repaid before February 23, 2021. We are also obligated to issue 10,000 shares of common stock and 200,000 400,000 3.50 five 600,298 10,000 During the nine months ended September 30, 2021, we issued 2,431,182 shares of common stock with a fair value of approximately $ 5.6 million to lenders for interest paid-in-kind, 248,200 shares with a fair value of $ 579,512 for services rendered, 1,035,996 shares with a fair value of $ 2,589,990 for conversions of debt principal and interest, 21,411 shares for stock option exercises (at an exercise price of $ 0.69 per share), 56,067 shares with a fair value of $ 114,298 for dividends paid-in-kind and 347,650 shares with a fair value of $ 551,198 for new convertible debt issuances and 36,290 shares of common stock for a non-cash warrant exercise. During this period, we also issued 1,558,266 warrants ( three to five -year term at a $ 3.50 to $ 5.00 exercise price) to acquire common stock at a fair value of $ 2.0 million to lenders in conjunction with signing of new convertible loans and interest paid-in-kind (including the 400,000 200 shares of Series AA preferred stock and 200,100 warrants to acquire common stock ( five year term and $ 3.50 exercise price) for settlement of liabilities, including accrued expense, accrued compensation to employees and non-convertible debt and related interest. The relative fair value of these warrants is $ 245,635 . The Company also recognized a $ 23,004 loss on settlement of liabilities, which is included in losses on extinguishment of liabilities on the consolidated statement of operations. During the nine months ended September 30, 2020, we issued to Series AA holders 87,518 shares of common stock for dividends totaling of $221,374 issued in stock in lieu of cash. During this period we also issued 1,202,118 shares of restricted common stock at a fair value of $2.8 million to accredited investors and consultants. 709,788 of the shares with a fair value of $1.8 million were issued for conversions of debt principal and interest; 315,830 of the shares with a fair value of $616,900 were issued for debt extensions, settlements and interest payments; 66,500 shares with a fair value of $127,855 were issued to settle an accrued liability; 85,000 147,775 25,000 shares with a fair value of $87,963 were issued for services rendered. During this period, we also issued 4,168,531 three five 3.50 5.6 110,000 44 44,000 five 3.50 38,783

Subsequent Events

Subsequent Events	9 Months Ended
	Sep. 30, 2021
Subsequent Events [Abstract]
Subsequent Events	7) Subsequent Events From October 1, 2021 through November 11, 2021 the Company received two fixed rate convertible loans for a total of $ 379,500 52,000 2.50 10 twelve- In this period the Company also partially repaid a convertible loan dated September 23, 2021 for $ 100,000, 160,000 15,000 13,000 15,000 23,000, 85,000 100,000

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
Basis of Presentation	Basis of Presentation The unaudited interim financial statements of Pressure BioSciences, Inc. and its consolidated subsidiaries (collectively, the “Company”) included herein have been prepared by the Company in accordance with the instructions to Form 10-Q and the rules and regulations of the U.S. Securities and Exchange Commission. Under these rules and regulations, some information and footnote disclosures normally included in financial statements prepared under accounting principles generally accepted in the United States of America have been shortened or omitted. Management believes that all adjustments necessary for a fair statement of the financial position and the results of operations for the periods shown have been made. All adjustments are normal and recurring. These financial statements should be read together with the Company’s audited financial statements included in its Form 10-K for the fiscal year ended December 31, 2020.
Use of Estimates	Use of Estimates The Company’s consolidated financial statements and accompanying notes are prepared in accordance with accounting principles generally accepted in the United States of America, which require the use of estimates, judgements and assumptions that affect the reported amounts of assets and liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the periods presented. Global concerns about the COVID-19 pandemic have adversely affected, and we expect will continue to adversely affect, our business, financial condition and results of operations including the estimates and assumptions made by management. Significant estimates and assumptions include valuations of share-based awards, investments in equity securities and intangible asset impairment. Actual results could differ from the estimates, and such differences may be material to the Company’s consolidated financial statements.
Principles of Consolidation	Principles of Consolidation The consolidated financial statements include the accounts of Pressure BioSciences, Inc., and its wholly owned subsidiaries PBI BioSeq, Inc and PBI Agrochem Inc. All intercompany accounts and transactions have been eliminated in consolidation.
Revenue Recognition	Revenue Recognition We recognize revenue in accordance with FASB ASC 606, Revenue from Contracts with Customers, ASC 340-40, Other Assets and Deferred Costs—Contracts with Customers We identify a performance obligation as distinct if both the following criteria are true: the customer can benefit from the good or service either on its own or together with other resources that are readily available to the customer and the entity’s promise to transfer the good or service to the customer is separately identifiable from other promises in the contract. Determining the standalone selling price (“SSP”) and allocation of consideration from a contract to the individual performance obligations, and the appropriate timing of revenue recognition, is the result of significant qualitative and quantitative judgments. Management considers a variety of factors such as historical sales, usage rates, costs, and expected margin, which may vary over time depending upon the unique facts and circumstances related to each performance obligation in making these estimates. While changes in the allocation of the SSP between performance obligations will not affect the amount of total revenue recognized for a particular contract, any material changes could impact the timing of revenue recognition, which would have a material effect on our financial position and result of operations. This is because the contract consideration is allocated to each performance obligation, delivered or undelivered, at the inception of the contract based on the SSP of each distinct performance obligation. Taxes assessed by a governmental authority that are both imposed on and concurrent with a specific revenue-producing transaction, that are collected by the Company from a customer, are excluded from revenue. Shipping and handling costs associated with outbound freight after control over a product has transferred to a customer are accounted for as a fulfillment cost and are in included in cost of revenues as consistent with treatment in prior periods. Our current Barocycler® instruments require a basic level of instrumentation expertise to set-up for initial operation. To support a favorable first experience for our customers, upon customer request, and for an additional fee, we will send a highly trained technical representative to the customer site to install Barocyclers® that we sell, lease, or rent through our domestic sales force. The installation process includes uncrating and setting up the instrument, followed by introductory user training. Our sales arrangements do not provide our customers with a right of return. Any shipping costs billed to customers are recognized as revenue. The majority of our instrument and consumable contracts contain pricing that is based on the market price for the product at the time of delivery. Our obligations to deliver product volumes are typically satisfied and revenue is recognized when control of the product transfers to our customers. Concurrent with the transfer of control, we typically receive the right to payment for the shipped product and the customer has significant risks and rewards of ownership of the product. Payment terms require customers to pay shortly after delivery and do not contain significant financing components. Revenue from scientific services customers is recognized upon completion of each stage of service as defined in service agreements. We apply ASC 845, “Accounting for Non-Monetary Transactions”, to account for products and services sold through non-cash transactions based on the fair values of the products and services involved, where such values can be determined. Non-cash exchanges would require revenue to be recognized at recorded cost or carrying value of the assets or services sold if any of the following conditions apply: a) The fair value of the asset or service involved is not determinable. b) The transaction is an exchange of a product or property held for sale in the ordinary course of business for a product or property to be sold in the same line of business to facilitate sales to customers other than the parties to the exchange. c) The transaction lacks commercial substance. We recognize revenue for non-cash transactions at recorded cost or carrying value of the assets or services sold. We account for lease agreements of our instruments in accordance with ASC 842, Leases. We record revenue over the life of the lease term, and we record depreciation expense on a straight-line basis over the thirty-six-month estimated useful life of the Barocycler® instrument. The depreciation expense associated with assets under lease agreement is included in the “Cost of PCT products and services” line item in our accompanying consolidated statements of operations. Many of our lease and rental agreements allow the lessee to purchase the instrument at any point during the term of the agreement with partial or full credit for payments previously made. We pay all maintenance costs associated with the instrument during the term of the leases. Deferred revenue represents amounts received from service contracts for which the related revenues have not been recognized because one or more of the revenue recognition criteria have not been met. Revenue from service contracts is recorded ratably over the length of the contract. Disaggregation of revenue In the following table, revenue is disaggregated by primary geographical market, major product line, and timing of revenue recognition. Schedule of Disaggregation of Revenue In thousands of US dollars ($) Three Months Ended September 30, Nine Months Ended September 30, Primary geographical markets 2021 2020 2021 2020 North America $ 351 $ 387 $ 1,036 $ 694 Europe 57 2 244 6 Asia 110 145 407 356 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Major products/services lines 2021 2020 2021 2020 Hardware $ 276 $ 313 $ 989 $ 569 Consumables 45 49 191 156 Contract research services 100 84 242 128 Sample preparation accessories 39 40 108 98 Technical support/extended service contracts 26 33 84 69 Shipping and handling 11 11 46 26 Other 21 4 27 10 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Timing of revenue recognition 2021 2020 2021 2020 Products transferred at a point in time $ 392 $ 417 $ 1,361 $ 859 Services transferred over time 126 117 326 197 $ 518 $ 534 $ 1,687 $ 1,056 Contract balances Schedule of Contract Balances In thousands of US dollars ($) September 30, 2021 December 31, 2020 Receivables, which are included in ‘Accounts Receivable’ $ 539 $ 131 Contract liabilities (deferred revenue) 53 67 Transaction price allocated to the remaining performance obligations. The following table includes estimated revenue expected to be recognized in the future related to performance obligations that are unsatisfied (or partially unsatisfied) at the end of the reporting period. Schedule of Future Related to Performance Obligations In thousands of US dollars ($) 2021 2022 Total Extended warranty service $ 44 $ 9 $ 53 All consideration from contracts with customers is included in the amounts presented above. Contract Costs The Company recognizes the incremental costs of obtaining contracts as an expense when incurred if the amortization period of the assets that the Company otherwise would have recognized is one year or less. These costs are included in selling, general, and administrative expenses. The costs to obtain a contract are recorded immediately in the period when the revenue is recognized either upon shipment or installation. The costs to obtain a service contract are considered immaterial when spread over the life of the contract so the Company records the costs immediately upon billing.
Concentrations	Concentrations Credit Risk Our financial instruments that potentially subject us to concentrations of credit risk consist primarily of cash, cash equivalents, and trade receivables. We have cash investment policies which, among other things, limit investments to investment-grade securities. We perform ongoing credit evaluations of our customers, and the risk with respect to trade receivables is further mitigated by the fact that many of our customers are government institutions, large pharmaceutical and biotechnology companies, and academic laboratories. The following table illustrates the level of concentration as a percentage of total revenues during the three and nine months ended September 30, 2021 and 2020. Schedule of Customer Concentration Risk Percentage For the Three Months Ended September 30, 2021 2020 Top Five Customers 56 % 59 % Federal Agencies 3 % 2 % For the Nine Months Ended September 30, 2021 2020 Top Five Customers 42 % 36 % Federal Agencies 6 % 3 % The following table illustrates the level of concentration as a percentage of net accounts receivable balance as of September 30, 2021 and December 31, 2020. The Top Five Customers category may include federal agency receivable balances if applicable. September 30, 2021 December 31, 2020 Top Five Customers 63 % 89 % Federal Agencies 2 % 10 %
Product Supply	Product Supply In recent years we utilized a contract assembler for our Barocycler® 2320EXT. They provided us with precision manufacturing services that included management support services to meet our specific application and operational requirements. Among the services provided to us were: ● CNC Machining ● Contract Assembly & Kitting ● Component and Subassembly Design ● Inventory Management ● ISO certification Beginning in July 2021, we brought the assembly of our Barocycler 2320EXT instruments in-house. This became necessary when our independent contract assembler (CBM Industries) informed us that they were about to need 100% of their assembly space for one of their customers, who was in fact one of the largest life science instrument manufacturers in the U.S. We worked with our notified body to gain approval to use both the CE and CSA marks on the instrument, which we received during Q3 2021. Until further notice, we expect to continue to assemble our Barocycler 2320EXT instrument at our Easton MA location. We currently manufacture and assemble the Barocycler®, HUB440, HUB880, the SHREDDER SG3, and most of our consumables at our South Easton, MA facility. We will regularly reassess the tradeoffs between in-house assembly versus the benefits of outsourced relationships for of the entire Barocycler® product line, and future instruments.
Investment in Equity Securities	Investment in Equity Securities As of September 30, 2021, we held 100,250 We account for this investment in accordance with ASC 320 “Investments — Debt and Equity Securities”. ASC 320 requires equity investments with readily determinable fair values to be measured at fair value with changes in fair value recognized in net income. As of September 30, 2021, our consolidated balance sheet reflected the fair value, determined on a recurring basis based on Level 1 inputs of our investment in Nexity, to be $ 112,550 . We recorded $ 404,451 as an unrealized loss during the nine months ended September 30, 2021 for changes in market value.
Computation of Loss per Share	Computation of Loss per Share Basic loss per share is computed by dividing loss available to common shareholders by the weighted average number of common shares outstanding. Diluted loss per share is computed by dividing loss available to common shareholders by the weighted average number of common shares outstanding plus additional common shares that would have been outstanding if dilutive potential common shares had been issued. For purposes of this calculation, convertible preferred stock, common stock dividends, and warrants and options to acquire common stock, are all considered common stock equivalents in periods in which they have a dilutive effect and are excluded from this calculation in periods in which these are anti-dilutive to our net loss. The following table illustrates our computation of loss per share for the three and nine months ended September 30, 2021 and 2020: Schedule of Computation of Loss Per Share 2021 2020 2021 2020 For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Numerator: Net loss attributable to common stockholders $ (6,199,176 ) $ (3,675,718 ) $ (18,387,204 ) $ (12,919,941 ) Denominator for basic and diluted loss per share: Weighted average common stock shares outstanding 7,561,728 3,612,958 6,083,017 3,059,095 Loss per common share – basic and diluted $ (0.82 ) $ (1.02 ) $ (3.02 ) $ (4.22 ) The following table presents securities that could potentially dilute basic loss per share in the future. For all periods presented, the potentially dilutive securities were not included in the computation of diluted loss per share because these securities would have been anti-dilutive to our net loss. The Series D Convertible Preferred Stock, Series G Convertible Preferred Stock, Series H and H2 Convertible Preferred Stock, Series J Convertible Preferred Stock, Series K Convertible Preferred Stock, and Series AA Convertible Preferred Stock are presented below as if they were converted into common shares according to the conversion terms. Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share As of September 30, 2021 2020 Stock options 1,342,490 1,392,370 Convertible debt 5,330,318 4,610,868 Common stock warrants 16,265,570 13,831,497 Convertible preferred stock: Series D Convertible Preferred Stock 25,000 25,000 Series G Convertible Preferred Stock 26,857 26,857 Series H Convertible Preferred Stock 33,334 33,334 Series H2 Convertible Preferred Stock 70,000 70,000 Series J Convertible Preferred Stock 115,267 115,267 Series K Convertible Preferred Stock 229,334 229,334 Series AA Convertible Preferred Stock 8,649,000 7,983,000 32,087,170 28,317,527
Accounting for Stock-Based Compensation Expense	Accounting for Stock-Based Compensation Expense We maintain equity compensation plans under which incentive stock options and non-qualified stock options are granted to employees, independent members of our Board of Directors and outside consultants. We recognize stock-based compensation expense over the requisite service period using the Black-Scholes formula to estimate the fair value of the stock options on the date of grant. Determining Fair Value of Stock Option Grants Valuation and Amortization Method - The fair value of each option award is estimated on the date of grant using the Black-Scholes pricing model based on certain assumptions. The estimated fair value of employee stock options is amortized to expense using the straight-line method over the vesting period. Expected Term - The Company uses the simplified calculation of expected life, as the Company does not currently have sufficient historical exercise data on which to base an estimate of expected term. Using this method, the expected term is determined using the average of the vesting period and the contractual life of the stock options granted. Expected Volatility - Expected volatility is based on the Company’s historical stock volatility data over the expected term of the award. Risk-Free Interest Rate - The Company bases the risk-free interest rate used in the Black-Scholes valuation method on the implied yield currently available on U.S. Treasury zero-coupon issues with an equivalent remaining term. Forfeitures - The Company records stock-based compensation expense only for those awards that are expected to vest. The Company estimated a forfeiture rate of 5% for awards granted based on historical experience and future expectations of options vesting. The Company used this historical rate as our assumption in calculating future stock-based compensation expense. The Company recognized stock-based compensation expense of $ 95,248 and $ 66,542 for the three months ended September 30, 2021 and 2020, respectively. The Company recognized stock-based compensation expense of $ 219,943 and $ 373,652 for the nine months ended September 30, 2021 and 2020, respectively. The following table summarizes the effect of this stock-based compensation expense within each of the line items of our costs and expenses within our Consolidated Statements of Operations: Schedule of Stock Based Compensation Expense For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Cost of sales $ 8,664 $ 5,164 $ 18,824 $ 18,227 Research and development 43,031 26,423 95,384 91,386 Selling and marketing 7,168 6,428 17,650 26,722 General and administrative 36,385 28,527 88,085 237,317 Total stock-based compensation expense $ 95,248 $ 66,542 $ 219,943 $ 373,652
Fair Value of Financial Instruments	Fair Value of Financial Instruments Due to their short maturities, the carrying amounts for cash and cash equivalents, accounts receivable, accounts payable, accrued expenses and debt approximate their fair value. The carrying amount of long-term debt approximates fair value due to interest rates that approximate prevailing market rates.
Fair Value Measurements	Fair Value Measurements The Company follows the guidance of FASB ASC Topic 820, “ Fair Value Measurements and Disclosures The Company generally defines fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date (exit price). The Company uses a three-tier fair value hierarchy, which classifies the inputs used in measuring fair values. These tiers include: Level 1, defined as observable inputs such as quoted prices for identical instruments in active markets; Level 2, defined as inputs other than quoted prices in active markets that are either directly or indirectly observable; and Level 3, defined as unobservable inputs in which little or no market data exists, therefore requiring the Company to develop its own assumptions. A slight change in an unobservable input like volatility could have a significant impact on fair value measurement. Financial assets and liabilities are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The Company has determined that its financial assets are classified within Level 1 in the fair value hierarchy. The development of the unobservable inputs for Level 3 fair value measurements and fair value calculations are the responsibility of the Company’s management. The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of September 30, 2021: Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis Fair value measurements at September 30, 2021 using: September 30, 2021 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities $ 112,550 $ 112,550 Total Financial Assets $ 112,550 $ 112,550 $ - $ - The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of December 31, 2020: Fair value measurements at December 31, 2020 using: December 31, 2020 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities 517,001 517,001 Total Financial Assets $ 517,001 $ 517,001 $ - $ -

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	9 Months Ended
	Sep. 30, 2021
Accounting Policies [Abstract]
Schedule of Disaggregation of Revenue	In the following table, revenue is disaggregated by primary geographical market, major product line, and timing of revenue recognition. Schedule of Disaggregation of Revenue In thousands of US dollars ($) Three Months Ended September 30, Nine Months Ended September 30, Primary geographical markets 2021 2020 2021 2020 North America $ 351 $ 387 $ 1,036 $ 694 Europe 57 2 244 6 Asia 110 145 407 356 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Major products/services lines 2021 2020 2021 2020 Hardware $ 276 $ 313 $ 989 $ 569 Consumables 45 49 191 156 Contract research services 100 84 242 128 Sample preparation accessories 39 40 108 98 Technical support/extended service contracts 26 33 84 69 Shipping and handling 11 11 46 26 Other 21 4 27 10 $ 518 $ 534 $ 1,687 $ 1,056 Three Months Ended September 30, Nine Months Ended September 30, Timing of revenue recognition 2021 2020 2021 2020 Products transferred at a point in time $ 392 $ 417 $ 1,361 $ 859 Services transferred over time 126 117 326 197 $ 518 $ 534 $ 1,687 $ 1,056
Schedule of Contract Balances	Contract balances Schedule of Contract Balances In thousands of US dollars ($) September 30, 2021 December 31, 2020 Receivables, which are included in ‘Accounts Receivable’ $ 539 $ 131 Contract liabilities (deferred revenue) 53 67
Schedule of Future Related to Performance Obligations	Schedule of Future Related to Performance Obligations In thousands of US dollars ($) 2021 2022 Total Extended warranty service $ 44 $ 9 $ 53
Schedule of Customer Concentration Risk Percentage	The following table illustrates the level of concentration as a percentage of total revenues during the three and nine months ended September 30, 2021 and 2020. Schedule of Customer Concentration Risk Percentage For the Three Months Ended September 30, 2021 2020 Top Five Customers 56 % 59 % Federal Agencies 3 % 2 % For the Nine Months Ended September 30, 2021 2020 Top Five Customers 42 % 36 % Federal Agencies 6 % 3 % The following table illustrates the level of concentration as a percentage of net accounts receivable balance as of September 30, 2021 and December 31, 2020. The Top Five Customers category may include federal agency receivable balances if applicable. September 30, 2021 December 31, 2020 Top Five Customers 63 % 89 % Federal Agencies 2 % 10 %
Schedule of Computation of Loss Per Share	The following table illustrates our computation of loss per share for the three and nine months ended September 30, 2021 and 2020: Schedule of Computation of Loss Per Share 2021 2020 2021 2020 For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Numerator: Net loss attributable to common stockholders $ (6,199,176 ) $ (3,675,718 ) $ (18,387,204 ) $ (12,919,941 ) Denominator for basic and diluted loss per share: Weighted average common stock shares outstanding 7,561,728 3,612,958 6,083,017 3,059,095 Loss per common share – basic and diluted $ (0.82 ) $ (1.02 ) $ (3.02 ) $ (4.22 )
Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share	Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share As of September 30, 2021 2020 Stock options 1,342,490 1,392,370 Convertible debt 5,330,318 4,610,868 Common stock warrants 16,265,570 13,831,497 Convertible preferred stock: Series D Convertible Preferred Stock 25,000 25,000 Series G Convertible Preferred Stock 26,857 26,857 Series H Convertible Preferred Stock 33,334 33,334 Series H2 Convertible Preferred Stock 70,000 70,000 Series J Convertible Preferred Stock 115,267 115,267 Series K Convertible Preferred Stock 229,334 229,334 Series AA Convertible Preferred Stock 8,649,000 7,983,000 32,087,170 28,317,527
Schedule of Stock Based Compensation Expense	Schedule of Stock Based Compensation Expense For the Three Months Ended For the Nine Months Ended September 30, September 30, 2021 2020 2021 2020 Cost of sales $ 8,664 $ 5,164 $ 18,824 $ 18,227 Research and development 43,031 26,423 95,384 91,386 Selling and marketing 7,168 6,428 17,650 26,722 General and administrative 36,385 28,527 88,085 237,317 Total stock-based compensation expense $ 95,248 $ 66,542 $ 219,943 $ 373,652
Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis	The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of September 30, 2021: Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis Fair value measurements at September 30, 2021 using: September 30, 2021 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities $ 112,550 $ 112,550 Total Financial Assets $ 112,550 $ 112,550 $ - $ - The following tables set forth the Company’s financial assets and liabilities that were accounted for at fair value on a recurring basis as of December 31, 2020: Fair value measurements at December 31, 2020 using: December 31, 2020 Quoted prices in active markets (Level 1) Significant other observable inputs (Level 2) Significant unobservable inputs (Level 3) Equity Securities 517,001 517,001 Total Financial Assets $ 517,001 $ 517,001 $ - $ -

Commitments and Contingencies (

Commitments and Contingencies (Tables)	9 Months Ended
	Sep. 30, 2021
Commitments and Contingencies Disclosure [Abstract]
Schedule of Future Minimum Rental Payments Required Under Operating Leases	Schedule of Future Minimum Rental Payments Required Under Operating Leases 2021 2021 $ 42,696 2022 87,383 2023 87,383 Total minimum payments required $ 217,462

Convertible Debt and Other De_2

Convertible Debt and Other Debt (Tables)	9 Months Ended
	Sep. 30, 2021
Debt Disclosure [Abstract]
Schedule of Convertible Debts and Outstanding Balances	The specific terms of the convertible notes and outstanding balances as of September 30, 2021 are listed in the tables below. Schedule of Convertible Debts and Outstanding Balances Inception Date Term Loan Amount Outstanding balance with OID Original Issue Discount (OID) Interest Rate Conversion Price Deferred Finance Fees Discount for conversion feature and warrants/ shares May 17, 2018 (1) (2) 12 months $ 380,000 $ 166,703 $ 15,200 8 % $ 2.50 $ 15,200 $ 332,407 January 3, 2019 (1) (4) 6 months $ 50,000 $ 50,000 $ 2,500 24 % $ 7.50 $ 2,500 $ - June 4, 2019 (1) (2) 9 months $ 500,000 $ 302,484 $ - 8 % $ 2.50 $ 40,500 $ 70,631 July 19, 2019 (1) (2) 12 months $ 115,000 $ 115,000 $ - 4 % $ 2.50 $ 5,750 $ 15,460 September 27, 2019 12 months $ 78,750 $ 78,750 $ - 4 % $ 2.50 $ 3,750 $ 13,759 October 24,2019 12 months $ 78,750 $ 78,750 $ - 4 % $ 2.50 $ 3,750 $ - 11/15/2019 (1) 12 months $ 385,000 $ 320,000 $ 35,000 10 % $ 2.50 $ 35,000 $ 90,917 1/2/2020 12 months $ 330,000 $ 330,000 $ 30,000 10 % $ 2.50 $ 30,000 $ 91,606 1/24/2020 12 months $ 247,500 $ 247,500 $ 22,500 10 % $ 2.50 $ 22,500 $ 89,707 1/29/2020 (1) 12 months $ 363,000 $ 363,000 $ 33,000 10 % $ 2.50 $ 33,000 $ 297,000 2/12/2020 12 months $ 275,000 $ 275,000 $ 25,000 10 % $ 2.50 $ 25,000 $ 225,000 2/19/2020 (1) 12 months $ 165,000 $ 165,000 $ 15,000 10 % $ 2.50 $ 15,000 $ 135,000 3/11/2020 12 months $ 330,000 $ 330,000 $ 30,000 10 % $ 2.50 $ 30,000 $ 232,810 3/13/2020 12 months $ 165,000 $ 165,000 $ 15,000 10 % $ 2.50 $ 15,000 $ 60,705 3/26/2020 12 months $ 111,100 $ 111,100 $ 10,100 10 % $ 2.50 $ 10,100 $ 90,900 4/8/2020 12 months $ 276,100 $ 276,100 $ 25,100 10 % $ 2.50 $ 25,000 $ 221,654 4/17/2020 12 months $ 143,750 $ 143,750 $ 18,750 10 % $ 2.50 $ - $ 96,208 4/30/2020 12 months $ 546,250 $ 546,250 $ 71,250 10 % $ 2.50 $ 47,500 $ 427,500 5/6/2020 12 months $ 460,000 $ 460,000 $ 60,000 10 % $ 2.50 $ 40,000 $ 360,000 5/18/2020 12 months $ 546,250 $ 221,250 $ 46,250 10 % $ 2.50 $ 35,500 $ 439,500 6/2/2020 12 months $ 902,750 $ 652,750 $ 92,750 10 % $ 2.50 $ 58,900 $ 708,500 6/12/2020 12 months $ 57,500 $ 57,500 $ 7,500 10 % $ 2.50 $ 5,000 $ 45,000 6/22/2020 12 months $ 138,000 $ 138,000 $ 18,000 10 % $ 2.50 $ 12,000 $ 108,000 July 7, 2020 12 months $ 586,500 $ 586,500 $ 76,500 10 % $ 2.50 $ 51,000 $ 400,234 July 17, 2020 12 months $ 362,250 $ 362,250 $ 47,250 10 % $ 2.50 $ 31,500 $ 185,698 July 29, 2020 12 months $ 345,000 $ 345,000 $ 45,000 10 % $ 2.50 $ 30,000 $ 241,245 July 21, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 24,875 August 14, 2020 12 months $ 762,450 $ 462,450 $ 69,450 10 % $ 2.50 $ 66,300 $ 580,124 September 10, 2020 12 months $ 391,000 $ 391,000 $ 51,000 10 % $ 2.50 $ 34,000 $ 231,043 September 21, 2020 (1) (5) 12 months $ 345,000 $ 345,000 $ 45,000 10 % $ 2.50 $ 30,000 $ 66,375 September 23, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 20,500 September 25, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ - $ 19,125 December 3, 2020 12 months $ 299,000 $ 299,000 $ 39,000 10 % $ 2.50 $ 26,000 $ 197,882 October 22, 2020 (1) (5) 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 18,875 January 5, 2021 (1) 6 months $ 575,000 $ 475,000 $ 75,000 18 % $ 2.50 $ - $ - February 17, 2021 12 months $ 230,000 $ 230,000 $ 30,000 10 % $ 2.50 $ 20,000 $ 180,000 March 23, 2021 12 months $ 55,000 $ 55,000 $ 5,000 10 % $ 2.50 $ - $ 36,431 May 24, 2021 6 months $ 54,625 $ 54,625 $ 7,125 12 % $ 2.50 $ - $ - May 6, 2021 12 months $ 402,500 $ 402,500 $ 52,500 10 % $ 2.50 $ 35,000 $ 312,551 June 17, 2021 12 months $ 230,000 $ 230,000 $ 30,000 10 % $ 2.50 $ 20,000 $ 144,760 June 25, 2021 12 months $ 977,500 $ 977,500 $ 127,500 10 % $ 2.50 $ - $ 773,802 May 20, 2021 12 months $ 180,000 $ 30,000 $ 30,000 10 % $ 2.50 $ 15,000 $ 25,824 June 3, 2021 12 months $ 50,000 $ 50,000 $ 1,500 12 % $ 2.50 $ - $ 7,948 June 28, 2021 12 months $ 350,000 $ 350,000 $ 35,000 12 % (6 ) $ 22,750 $ 267,250 July 3, 2021 12 months $ 115,000 $ 115,000 $ 15,000 10 % $ 2.50 $ 10,000 $ 90,000 July 1, 2021 6 months $ 260,000 $ 260,000 $ 10,000 12 % $ 2.50 $ - $ 89,640 July 6, 2021 6 months $ 125,000 $ 125,000 $ - 12 % $ 2.50 $ - $ 42,031 July 6, 2021 6 months $ 125,000 $ 125,000 $ - 12 % $ 2.50 $ - $ 42,031 July 15, 2021 6 months $ 100,000 $ 100,000 $ 5,000 12 % (7 ) $ - $ 57,716 July 16, 2021 6 months $ 50,000 $ 50,000 $ 2,000 12 % $ 3.00 $ - $ 40,806 July 16, 2021 6 months $ 306,250 $ 306,250 $ 56,250 (3 ) (8 ) $ 22,500 $ 227,500 July 16, 2021 6 months $ 306,250 $ 306,250 $ 56,250 (3 ) (8 ) $ 12,500 $ 237,500 July 16, 2021 6 months $ 122,500 $ 122,500 $ 22,500 (3 ) (8 ) $ 5,000 $ 95,000 August 31, 2021 6 months $ 189,750 $ 189,750 $ 24,750 10 % (9 ) $ 16,500 $ 148,500 Sept. 8, 2021 8 months $ 78,000 $ 78,000 $ 3,000 12 % (7 ) $ - $ 40,449 Sept. 10, 2021 8 months $ 100,000 $ 100,000 $ 4,000 12 % (7 ) $ - $ 43,520 Sept. 15, 2021 8 months $ 250,000 $ 250,000 $ 12,500 12 % (7 ) $ - $ 108,801 Sept. 16, 2021 8 months $ 250,000 $ 250,000 $ 12,500 12 % (7 ) $ - $ 112,337 Sept. 24, 2021 8 months $ 125,000 $ 125,000 $ 6,250 12 % $ (7 ) $ - $ 61,876 Sept. 15, 2021 6 months $ 250,000 $ 250,000 $ 37,500 12 % $ (7 ) $ 30,000 $ - $ 14,452,462 $ 1,667,225 $ 1,019,000 $ 9,324,513 (1) The Note is past due. The Company and the lender are negotiating in good faith to extend the loan. (2) In recent quarters the Company and lenders have entered into Standstill and Forbearance Agreements (as described below). (3) Note is secured by the assets of the Company’s subsidiary, PBI Agrochem, Inc. and interest rate is 18.4% OID. (4) During the year ended December 31, 2020 the Company entered into a Rate Modification Agreement with this lender. In this agreement the lender agreed to reduce their interest rate and were granted the right to convert loans using a variable conversion price if more than one other variable rate lender converted at a variable rate. (5) The Company has agreed to issue shares of its common stock to lenders if their notes are not repaid by a defined date. (6) Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $ 2.50 90 (7) Notes are convertible before maturity at $ 2.50 (8) Notes can be converted at the lesser of $ 2.50 25 (9) Conversion price of this note is $ 2.50
Summary of Changes in Convertible Debt and Revolving Note Payable, Net of Unamortized Discounts	The following table provides a summary of the changes in convertible debt, net of unamortized discounts, during 2021: Summary of Changes in Convertible Debt and Revolving Note Payable, Net of Unamortized Discounts 2021 Balance at January 1, $ 7,545,670 Issuance of convertible debt, face value 5,857,375 Deferred financing cost (802,875 ) Beneficial conversion feature on convertible note (1,231,528 ) Debt discount from shares and warrants issued with debt (1,954,744 ) Payments (1,608,295 ) Conversion of debt into equity (1,305,455 ) Accretion of interest and amortization of debt discount to interest expense 5,260,151 Balance at September 30, 11,760,299 Less: current portion 11,760,299 Convertible debt, long-term portion $ –
Schedule of Merchant Agreements	The following table shows our Merchant Agreements as of September 30, 2021: Schedule of Merchant Agreements Inception Date Purchase Price Purchased Amount Outstanding Balance Daily Payment Rate Deferred Finance Fees March 26, 2021 240,000 330,960 20,775 2,364 - May 3, 2021 200,000 275,800 51,470 1,970 5,000 June 2, 2021 135,000 186,165 61,657 1,400 1,350 July 6, 2021 125,000 166,250 76,416 1,279 2,500 $ 700,000 $ 959,175 $ 210,318 $ 7,013 $ 8,850 The following table shows our Merchant Agreements as of December 31, 2020: Inception Date Purchase Price Purchased Amount Outstanding Balance Daily Payment Rate Deferred Finance Fees November 5, 2020 $ 200,000 $ 275,800 $ 163,955 1,724 $ - November 19, 2020 100,000 137,900 85,013 985 - $ 300,000 $ 413,700 $ 248,968 $ 2,709 $ -

Stockholders_ Deficit (Tables)

Stockholders’ Deficit (Tables)	9 Months Ended
	Sep. 30, 2021
Equity [Abstract]
Schedule of Concerning Options and Warrants Outstanding and Exercisable	The following table summarizes information concerning options and warrants outstanding and exercisable: Schedule of Concerning Options and Warrants Outstanding and Exercisable Stock Options Warrants Weighted Weighted Average Average Shares price Shares price Shares Total Balance outstanding, December 31, 2020 1,355,901 $ 0.69 14,434,702 $ 3.50 15,790,603 15,302,830 Granted 24,000 2.17 2,164,366 3.59 2,188,366 - Exercised (21,411 ) 0.69 (187,500 ) 3.50 (208,911 ) - Expired/forfeited (16,000 ) 0.69 (145,998 ) $ 3.50 (161,998 ) - Balance outstanding, September 30, 2021 1,342,490 $ 0.72 16,265,570 $ 3.50 17,608,060 17,313,673
Schedule of Loans Obligated to Issue Shares	As profiled in the following table, for five loans we are obligated to issue common stock if not paid by defined dates. Schedule of Loans Obligated to Issue Shares Loan Issuance Loan Shares Defined Defined Loan Date Principal Issuable Date Frequency Loan 1 July 21, 2020 $ 115,000 5,000 September 30, 2020 Monthly Loan 2 September 21, 2020 $ 345,000 12,500 November 16, 2020 Weekly Loan 3 September 23, 2020 $ 115,000 12,500 December 1, 2020 Weekly Loan 4 September 25, 2020 $ 115,000 12,500 December 1, 2020 Weekly Loan 5 October 22, 2020 $ 115,000 12,500 December 1, 2020 Weekly

Schedule of Disaggregation of R

Schedule of Disaggregation of Revenue (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Product Information [Line Items]
Revenue	$ 518,365	$ 533,862	$ 1,687,166	$ 1,055,889
Hardware [Member]
Product Information [Line Items]
Revenue	276,000	313,000	989,000	569,000
Consumables [Member]
Product Information [Line Items]
Revenue	45,000	49,000	191,000	156,000
Contract Research Services [Member]
Product Information [Line Items]
Revenue	100,000	84,000	242,000	128,000
Sample Preparation Accessories [Member]
Product Information [Line Items]
Revenue	39,000	40,000	108,000	98,000
Technical Support/Extended Service Contracts [Member]
Product Information [Line Items]
Revenue	26,000	33,000	84,000	69,000
Shipping and Handling [Member]
Product Information [Line Items]
Revenue	11,000	11,000	46,000	26,000
Others [Member]
Product Information [Line Items]
Revenue	21,000	4,000	27,000	10,000
Major Products Services Lines [Member]
Product Information [Line Items]
Revenue	518,000	534,000	1,687,000	1,056,000
Transferred at a Point in Time [Member]
Product Information [Line Items]
Revenue	392,000	417,000	1,361,000	859,000
Transferred Over Time [Member]
Product Information [Line Items]
Revenue	126,000	117,000	326,000	197,000
Timing Of Revenue Recognition [Member]
Product Information [Line Items]
Revenue	518,000	534,000	1,687,000	1,056,000
North America [Member]
Product Information [Line Items]
Revenue	351,000	387,000	1,036,000	694,000
Europe [Member]
Product Information [Line Items]
Revenue	57,000	2,000	244,000	6,000
Asia [Member]
Product Information [Line Items]
Revenue	110,000	145,000	407,000	356,000
Primary Geographical Markets [Member]
Product Information [Line Items]
Revenue	$ 518,000	$ 534,000	$ 1,687,000	$ 1,056,000

Schedule of Contract Balances (

Schedule of Contract Balances (Details) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Accounting Policies [Abstract]
Receivables, which are included in ‘Accounts Receivable’	$ 539	$ 131
Contract liabilities (deferred revenue)	$ 53	$ 67

Schedule of Future Related to P

Schedule of Future Related to Performance Obligations (Details) $ in Thousands	Sep. 30, 2021USD ($)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended warranty service	$ 53
2021 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended warranty service	44
2022 [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Extended warranty service	$ 9

Schedule of Customer Concentrat

Schedule of Customer Concentration Risk Percentage (Details) - Customer Concentration Risk [Member]	3 Months Ended		9 Months Ended		12 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020
Top Five Customers [Member] | Revenue Benchmark [Member]
Product Information [Line Items]
Concentration credit risk percentage	56.00%	59.00%	42.00%	36.00%
Top Five Customers [Member] | Accounts Receivable [Member]
Product Information [Line Items]
Concentration credit risk percentage			63.00%		89.00%
Federal Agencies [Member] | Revenue Benchmark [Member]
Product Information [Line Items]
Concentration credit risk percentage	3.00%	2.00%	6.00%	3.00%
Federal Agencies [Member] | Accounts Receivable [Member]
Product Information [Line Items]
Concentration credit risk percentage			2.00%		10.00%

Schedule of Computation of Loss

Schedule of Computation of Loss Per Share (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Accounting Policies [Abstract]
Net loss attributable to common stockholders	$ (6,199,176)	$ (3,675,718)	$ (18,387,204)	$ (12,919,941)
Weighted average common stock shares outstanding	7,561,728	3,612,958	6,083,017	3,059,095
Loss per common share – basic and diluted	$ (0.82)	$ (1.02)	$ (3.02)	$ (4.22)

Schedule of Anti-dilutive Secur

Schedule of Anti-dilutive Securities Excluded from Computation of Earnings Per Share (Details) - shares	9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	32,087,170	28,317,527
Stock Options [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	1,342,490	1,392,370
Convertible Debt Securities [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	5,330,318	4,610,868
Common Stock Warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	16,265,570	13,831,497
Series D Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	25,000	25,000
Series G Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	26,857	26,857
Series H Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	33,334	33,334
Series H Two Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	70,000	70,000
Series J Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	115,267	115,267
Series K Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	229,334	229,334
Series AA Convertible Preferred Stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Total potentially dilutive shares	8,649,000	7,983,000

Schedule of Stock Based Compens

Schedule of Stock Based Compensation Expense (Details) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Total stock-based compensation expense	$ 95,248	$ 66,542	$ 219,943	$ 373,652
Cost of Sales [Member]
Total stock-based compensation expense	8,664	5,164	18,824	18,227
Research and Development Expense [Member]
Total stock-based compensation expense	43,031	26,423	95,384	91,386
Selling and Marketing Expense [Member]
Total stock-based compensation expense	7,168	6,428	17,650	26,722
General and Administrative Expense [Member]
Total stock-based compensation expense	$ 36,385	$ 28,527	$ 88,085	$ 237,317

Schedule of Assets and Liabilit

Schedule of Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) - USD ($)	Sep. 30, 2021	Dec. 31, 2020
Financing Receivable, Impaired [Line Items]
Total Financial Assets	$ 112,550	$ 517,001
Fair Value, Inputs, Level 1 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets	112,550	517,001
Fair Value, Inputs, Level 2 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets
Fair Value, Inputs, Level 3 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets
Equity Securities [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets	112,550	517,001
Equity Securities [Member] | Fair Value, Inputs, Level 1 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets	112,550	517,001
Equity Securities [Member] | Fair Value, Inputs, Level 2 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets
Equity Securities [Member] | Fair Value, Inputs, Level 3 [Member]
Financing Receivable, Impaired [Line Items]
Total Financial Assets

Summary of Significant Accoun_4

Summary of Significant Accounting Policies (Details Narrative) - USD ($)	3 Months Ended		9 Months Ended
	Sep. 30, 2021	Sep. 30, 2020	Sep. 30, 2021	Sep. 30, 2020
Share-based Payment Arrangement, Noncash Expense	$ 95,248	$ 66,542	$ 219,943	$ 373,652
Nexity Global SA [Member]
Sale of Stock, Number of Shares Issued in Transaction			100,250
Investment Owned, at Fair Value	$ 112,550		$ 112,550
Marketable Securities, Realized Gain (Loss)			$ 404,451

Schedule of Future Minimum Rent

Schedule of Future Minimum Rental Payments Required Under Operating Leases (Details)	Sep. 30, 2021USD ($)
Commitments and Contingencies Disclosure [Abstract]
2021	$ 42,696
2022	87,383
2023	87,383
Total minimum payments required	$ 217,462

Commitments and Contingencies_2

Commitments and Contingencies (Details Narrative) - USD ($)	9 Months Ended	12 Months Ended
	Sep. 30, 2021	Dec. 31, 2020
SEC Schedule, 12-28, Real Estate Companies, Investment in Real Estate and Accumulated Depreciation [Line Items]
Payments for rent	$ 7,282
Lessee, operating lease, description	The lease shall be automatically extended for additional three years unless either party terminates at least six months prior to the expiration of the current lease term.
Operating lease, liability	$ 221,432
Operating lease, weighted average discount rate, percent	12.00%
Target Discovery Inc [Member]
SEC Schedule, 12-28, Real Estate Companies, Investment in Real Estate and Accumulated Depreciation [Line Items]
Professional Fees	$ 44,600
Corporate Office [Member]
SEC Schedule, 12-28, Real Estate Companies, Investment in Real Estate and Accumulated Depreciation [Line Items]
Payments for rent		$ 6,950
Lease expiration date		Dec. 31, 2021

Schedule of Convertible Debts a

Schedule of Convertible Debts and Outstanding Balances (Details) - USD ($)		9 Months Ended
		Sep. 30, 2021	Dec. 31, 2020
Short-term Debt [Line Items]
Outstanding balance with OID		$ 11,760,299	$ 7,545,670
Original Issue Discount (OID)		1,305,455
Deferred Finance Fees		8,850
Discount for conversion feature and warrants/shares		$ 1,231,528
Debt instrument, convertible price per shares		$ 2.50
Debt instrument lowest trading price		25.00%
Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Outstanding balance with OID		$ 14,452,462
Original Issue Discount (OID)		1,667,225
Deferred Finance Fees		1,019,000
Discount for conversion feature and warrants/shares		$ 9,324,513
Convertible Debt One [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	May 17, 2018
Debenture conversion term		12 months
Loan Amount		$ 380,000
Outstanding balance with OID		166,703
Original Issue Discount (OID)		$ 15,200
Interest Rate		8.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 15,200
Discount for conversion feature and warrants/shares		$ 332,407
Debt Instrument, Interest Rate, Stated Percentage		(8.00%)
Convertible Debt Two [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[2]	Jan. 3, 2019
Debenture conversion term		6 months
Loan Amount		$ 50,000
Outstanding balance with OID		50,000
Original Issue Discount (OID)		$ 2,500
Interest Rate		24.00%
Conversion Price		$ 7.50
Deferred Finance Fees		$ 2,500
Discount for conversion feature and warrants/shares
Debt Instrument, Interest Rate, Stated Percentage		(24.00%)
Convertible Debt Three [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jun. 4, 2019
Debenture conversion term		9 months
Loan Amount		$ 500,000
Outstanding balance with OID		302,484
Original Issue Discount (OID)
Interest Rate		8.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 40,500
Discount for conversion feature and warrants/shares		$ 70,631
Debt Instrument, Interest Rate, Stated Percentage		(8.00%)
Convertible Debt Four [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jul. 19, 2019
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)
Interest Rate		4.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 5,750
Discount for conversion feature and warrants/shares		$ 15,460
Debt Instrument, Interest Rate, Stated Percentage		(4.00%)
Convertible Debt Five [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Sep. 27, 2019
Debenture conversion term		12 months
Loan Amount		$ 78,750
Outstanding balance with OID		78,750
Original Issue Discount (OID)
Interest Rate		4.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 3,750
Discount for conversion feature and warrants/shares		$ 13,759
Debt Instrument, Interest Rate, Stated Percentage		(4.00%)
Convertible Debt Six [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Oct. 24, 2019
Debenture conversion term		12 months
Loan Amount		$ 78,750
Outstanding balance with OID		78,750
Original Issue Discount (OID)
Interest Rate		4.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 3,750
Discount for conversion feature and warrants/shares
Debt Instrument, Interest Rate, Stated Percentage		(4.00%)
Convertible Debt Seven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Nov. 15, 2019
Debenture conversion term		12 months
Loan Amount		$ 385,000
Outstanding balance with OID		320,000
Original Issue Discount (OID)		$ 35,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 35,000
Discount for conversion feature and warrants/shares		$ 90,917
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Eight [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jan. 2, 2020
Debenture conversion term		12 months
Loan Amount		$ 330,000
Outstanding balance with OID		330,000
Original Issue Discount (OID)		$ 30,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 30,000
Discount for conversion feature and warrants/shares		$ 91,606
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Nine [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jan. 24, 2020
Debenture conversion term		12 months
Loan Amount		$ 247,500
Outstanding balance with OID		247,500
Original Issue Discount (OID)		$ 22,500
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 22,500
Discount for conversion feature and warrants/shares		$ 89,707
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Ten [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jan. 29, 2020
Debenture conversion term		12 months
Loan Amount		$ 363,000
Outstanding balance with OID		363,000
Original Issue Discount (OID)		$ 33,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 33,000
Discount for conversion feature and warrants/shares		$ 297,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Eleven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Feb. 12, 2020
Debenture conversion term		12 months
Loan Amount		$ 275,000
Outstanding balance with OID		275,000
Original Issue Discount (OID)		$ 25,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 25,000
Discount for conversion feature and warrants/shares		$ 225,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twelve [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Feb. 19, 2020
Debenture conversion term		12 months
Loan Amount		$ 165,000
Outstanding balance with OID		165,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 15,000
Discount for conversion feature and warrants/shares		$ 135,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Mar. 11, 2020
Debenture conversion term		12 months
Loan Amount		$ 330,000
Outstanding balance with OID		330,000
Original Issue Discount (OID)		$ 30,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 30,000
Discount for conversion feature and warrants/shares		$ 232,810
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Fourteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Mar. 13, 2020
Debenture conversion term		12 months
Loan Amount		$ 165,000
Outstanding balance with OID		165,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		1000.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 15,000
Discount for conversion feature and warrants/shares		$ 60,705
Debt Instrument, Interest Rate, Stated Percentage		(1000.00%)
Convertible Debt Fifteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Mar. 26, 2020
Debenture conversion term		12 months
Loan Amount		$ 111,100
Outstanding balance with OID		111,100
Original Issue Discount (OID)		$ 10,100
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 10,100
Discount for conversion feature and warrants/shares		$ 90,900
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Sixteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Apr. 8, 2020
Debenture conversion term		12 months
Loan Amount		$ 276,100
Outstanding balance with OID		276,100
Original Issue Discount (OID)		$ 25,100
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 25,000
Discount for conversion feature and warrants/shares		$ 221,654
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Seventeen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Apr. 17, 2020
Debenture conversion term		12 months
Loan Amount		$ 143,750
Outstanding balance with OID		143,750
Original Issue Discount (OID)		$ 18,750
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 96,208
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Eighteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Apr. 30, 2020
Debenture conversion term		12 months
Loan Amount		$ 546,250
Outstanding balance with OID		546,250
Original Issue Discount (OID)		$ 71,250
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 47,500
Discount for conversion feature and warrants/shares		$ 427,500
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Nineteen [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	May 6, 2020
Debenture conversion term		12 months
Loan Amount		$ 460,000
Outstanding balance with OID		460,000
Original Issue Discount (OID)		$ 60,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 40,000
Discount for conversion feature and warrants/shares		$ 360,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	May 18, 2020
Debenture conversion term		12 months
Loan Amount		$ 546,250
Outstanding balance with OID		221,250
Original Issue Discount (OID)		$ 46,250
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 35,500
Discount for conversion feature and warrants/shares		$ 439,500
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty One [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jun. 2, 2020
Debenture conversion term		12 months
Loan Amount		$ 902,750
Outstanding balance with OID		652,750
Original Issue Discount (OID)		$ 92,750
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 58,900
Discount for conversion feature and warrants/shares		$ 708,500
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Two [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jun. 12, 2020
Debenture conversion term		12 months
Loan Amount		$ 57,500
Outstanding balance with OID		57,500
Original Issue Discount (OID)		$ 7,500
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 5,000
Discount for conversion feature and warrants/shares		$ 45,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Three [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jun. 22, 2020
Debenture conversion term		12 months
Loan Amount		$ 138,000
Outstanding balance with OID		138,000
Original Issue Discount (OID)		$ 18,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 12,000
Discount for conversion feature and warrants/shares		$ 108,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Four [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jul. 7, 2020
Debenture conversion term		12 months
Loan Amount		$ 586,500
Outstanding balance with OID		586,500
Original Issue Discount (OID)		$ 76,500
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 51,000
Discount for conversion feature and warrants/shares		$ 400,234
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Five [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jul. 17, 2020
Debenture conversion term		12 months
Loan Amount		$ 362,250
Outstanding balance with OID		362,250
Original Issue Discount (OID)		$ 47,250
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 31,500
Discount for conversion feature and warrants/shares		$ 185,698
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Six [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jul. 29, 2020
Debenture conversion term		12 months
Loan Amount		$ 345,000
Outstanding balance with OID		345,000
Original Issue Discount (OID)		$ 45,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 30,000
Discount for conversion feature and warrants/shares		$ 241,245
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Seven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[3]	Jul. 21, 2020
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 10,000
Discount for conversion feature and warrants/shares		$ 24,875
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Eight [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Aug. 14, 2020
Debenture conversion term		12 months
Loan Amount		$ 762,450
Outstanding balance with OID		462,450
Original Issue Discount (OID)		$ 69,450
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 66,300
Discount for conversion feature and warrants/shares		$ 580,124
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Twenty Nine [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Sep. 10, 2020
Debenture conversion term		12 months
Loan Amount		$ 391,000
Outstanding balance with OID		391,000
Original Issue Discount (OID)		$ 51,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 34,000
Discount for conversion feature and warrants/shares		$ 231,043
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[3]	Sep. 21, 2020
Debenture conversion term		12 months
Loan Amount		$ 345,000
Outstanding balance with OID		345,000
Original Issue Discount (OID)		$ 45,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 30,000
Discount for conversion feature and warrants/shares		$ 66,375
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty One [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[3]	Sep. 23, 2020
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 10,000
Discount for conversion feature and warrants/shares		$ 20,500
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Two [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[3]	Sep. 25, 2020
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 19,125
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Three [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Dec. 3, 2020
Debenture conversion term		12 months
Loan Amount		$ 299,000
Outstanding balance with OID		299,000
Original Issue Discount (OID)		$ 39,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 26,000
Discount for conversion feature and warrants/shares		$ 197,882
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Four [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1],[3]	Oct. 22, 2020
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 10,000
Discount for conversion feature and warrants/shares		$ 18,875
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Five [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[1]	Jan. 5, 2021
Debenture conversion term		6 months
Loan Amount		$ 575,000
Outstanding balance with OID		475,000
Original Issue Discount (OID)		$ 75,000
Interest Rate		18.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares
Debt Instrument, Interest Rate, Stated Percentage		(18.00%)
Convertible Debt Thirty Six [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Feb. 17, 2021
Debenture conversion term		12 months
Loan Amount		$ 230,000
Outstanding balance with OID		230,000
Original Issue Discount (OID)		$ 30,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 20,000
Discount for conversion feature and warrants/shares		$ 180,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Seven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Mar. 23, 2021
Debenture conversion term		12 months
Loan Amount		$ 55,000
Outstanding balance with OID		55,000
Original Issue Discount (OID)		$ 5,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 36,431
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Thirty Eight [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		May 24, 2021
Debenture conversion term		6 months
Loan Amount		$ 54,625
Outstanding balance with OID		54,625
Original Issue Discount (OID)		$ 7,125
Interest Rate		12.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Thirty Nine [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		May 6, 2021
Debenture conversion term		12 months
Loan Amount		$ 402,500
Outstanding balance with OID		402,500
Original Issue Discount (OID)		$ 52,500
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 35,000
Discount for conversion feature and warrants/shares		$ 312,551
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Forty [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jun. 17, 2021
Debenture conversion term		12 months
Loan Amount		$ 230,000
Outstanding balance with OID		230,000
Original Issue Discount (OID)		$ 30,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 20,000
Discount for conversion feature and warrants/shares		$ 144,760
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Forty One [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jun. 25, 2021
Debenture conversion term		12 months
Loan Amount		$ 977,500
Outstanding balance with OID		977,500
Original Issue Discount (OID)		$ 127,500
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 773,802
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Forty Two [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		May 20, 2021
Debenture conversion term		12 months
Loan Amount		$ 180,000
Outstanding balance with OID		30,000
Original Issue Discount (OID)		$ 30,000
Interest Rate		10.00%
Conversion Price		$ 2.50
Deferred Finance Fees		$ 15,000
Discount for conversion feature and warrants/shares		$ 25,824
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Forty Three [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jun. 3, 2021
Debenture conversion term		12 months
Loan Amount		$ 50,000
Outstanding balance with OID		50,000
Original Issue Discount (OID)		$ 1,500
Interest Rate		12.00%
Conversion Price		$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 7,948
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Forty Four [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jun. 28, 2021
Debenture conversion term		12 months
Loan Amount		$ 350,000
Outstanding balance with OID		350,000
Original Issue Discount (OID)		$ 35,000
Interest Rate		12.00%
Conversion Price	[4]	$ 6
Deferred Finance Fees		$ 22,750
Discount for conversion feature and warrants/shares		$ 267,250
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Forty Five [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 3, 2021
Debenture conversion term		12 months
Loan Amount		$ 115,000
Outstanding balance with OID		115,000
Original Issue Discount (OID)		$ 15,000
Interest Rate		10.00%
Conversion Price	[4]	$ 2.50
Deferred Finance Fees		$ 10,000
Discount for conversion feature and warrants/shares		$ 90,000
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Forty Six [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 1, 2021
Debenture conversion term		6 months
Loan Amount		$ 260,000
Outstanding balance with OID		260,000
Original Issue Discount (OID)		$ 10,000
Interest Rate		12.00%
Conversion Price	[4]	$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 89,640
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Forty Seven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 6, 2021
Debenture conversion term		6 months
Loan Amount		$ 125,000
Outstanding balance with OID		125,000
Original Issue Discount (OID)
Interest Rate		12.00%
Conversion Price	[4]	$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 42,031
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Forty Eight [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 6, 2021
Debenture conversion term		6 months
Loan Amount		$ 125,000
Outstanding balance with OID		125,000
Original Issue Discount (OID)
Interest Rate		12.00%
Conversion Price	[4]	$ 2.50
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 42,031
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Forty Nine [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 15, 2021
Debenture conversion term		6 months
Loan Amount		$ 100,000
Outstanding balance with OID		100,000
Original Issue Discount (OID)		$ 5,000
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 57,716
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Jul. 16, 2021
Debenture conversion term		6 months
Loan Amount		$ 50,000
Outstanding balance with OID		50,000
Original Issue Discount (OID)		$ 2,000
Interest Rate		12.00%
Conversion Price	[4]	$ 3
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 40,806
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty One [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[5]	Jul. 16, 2021
Debenture conversion term		6 months
Loan Amount		$ 306,250
Outstanding balance with OID		306,250
Original Issue Discount (OID)		$ 56,250
Interest Rate		3.00%
Conversion Price	[4]	$ 8
Deferred Finance Fees		$ 22,500
Discount for conversion feature and warrants/shares		$ 227,500
Debt Instrument, Interest Rate, Stated Percentage		(3.00%)
Convertible Debt Fifty Two [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[5]	Jul. 16, 2021
Debenture conversion term		6 months
Loan Amount		$ 306,250
Outstanding balance with OID		306,250
Original Issue Discount (OID)		$ 56,250
Interest Rate		3.00%
Conversion Price	[4]	$ 8
Deferred Finance Fees		$ 12,500
Discount for conversion feature and warrants/shares		$ 237,500
Debt Instrument, Interest Rate, Stated Percentage		(3.00%)
Convertible Debt Fifty Three [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date	[5]	Jul. 16, 2021
Debenture conversion term		6 months
Loan Amount		$ 122,500
Outstanding balance with OID		122,500
Original Issue Discount (OID)		$ 22,500
Interest Rate		3.00%
Conversion Price	[4]	$ 8
Deferred Finance Fees		$ 5,000
Discount for conversion feature and warrants/shares		$ 95,000
Debt Instrument, Interest Rate, Stated Percentage		(3.00%)
Convertible Debt Fifty Four [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Aug. 31, 2021
Debenture conversion term		6 months
Loan Amount		$ 189,750
Outstanding balance with OID		189,750
Original Issue Discount (OID)		$ 24,750
Interest Rate		10.00%
Conversion Price	[4]	$ 9
Deferred Finance Fees		$ 16,500
Discount for conversion feature and warrants/shares		$ 148,500
Debt Instrument, Interest Rate, Stated Percentage		(10.00%)
Convertible Debt Fifty Five [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 8, 2021
Debenture conversion term		8 months
Loan Amount		$ 78,000
Outstanding balance with OID		78,000
Original Issue Discount (OID)		$ 3,000
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 40,449
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty Six [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 10, 2021
Debenture conversion term		8 months
Loan Amount		$ 100,000
Outstanding balance with OID		100,000
Original Issue Discount (OID)		$ 4,000
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 43,520
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty Seven [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 15, 2021
Debenture conversion term		8 months
Loan Amount		$ 250,000
Outstanding balance with OID		250,000
Original Issue Discount (OID)		$ 12,500
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 108,801
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty Eight [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 16, 2021
Debenture conversion term		8 months
Loan Amount		$ 250,000
Outstanding balance with OID		250,000
Original Issue Discount (OID)		$ 12,500
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 112,337
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Fifty Nine [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 24, 2021
Debenture conversion term		8 months
Loan Amount		$ 125,000
Outstanding balance with OID		125,000
Original Issue Discount (OID)		$ 6,250
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees
Discount for conversion feature and warrants/shares		$ 61,876
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
Convertible Debt Sixty [Member] | Fixed Rate Convertible Notes [Member]
Short-term Debt [Line Items]
Inception Date		Sep. 15, 2021
Debenture conversion term		6 months
Loan Amount		$ 250,000
Outstanding balance with OID		250,000
Original Issue Discount (OID)		$ 37,500
Interest Rate		12.00%
Conversion Price	[4]	$ 7
Deferred Finance Fees		$ 30,000
Discount for conversion feature and warrants/shares
Debt Instrument, Interest Rate, Stated Percentage		(12.00%)
[1]	The Note is past due. The Company and the lender are negotiating in good faith to extend the loan.
[2]	During the year ended December 31, 2020 the Company entered into a Rate Modification Agreement with this lender. In this agreement the lender agreed to reduce their interest rate and were granted the right to convert loans using a variable conversion price if more than one other variable rate lender converted at a variable rate.
[3]	The Company has agreed to issue shares of its common stock to lenders if their notes are not repaid by a defined date.
[4]	Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $ 2.50 90
[5]	Note is secured by the assets of the Company’s subsidiary, PBI Agrochem, Inc. and interest rate is 18.4% OID.

Schedule of Convertible Debts_2

Schedule of Convertible Debts and Outstanding Balances (Details) (Parenthetical) - $ / shares	Dec. 23, 2020	Sep. 30, 2021
Debt Disclosure [Abstract]
Debt instrument, description	we are obligated to issue 100,000 warrants if the loan is not repaid before January 23, 2021 and an additional 10,000 shares of common stock and 100,000 warrants if the loan is not repaid before February 23, 2021. We are also obligated to issue 10,000 shares of common stock and 200,000 warrants if the loan is not repaid before March 23, 2021. During the nine months ended September 30, 2021 the Company issued 400,000 warrants to this lender ($3.50 exercise price and five-year term) with a fair value of $600,298. The Company is also obligated to issue 10,000 shares of common stock to this lender every 31 days up to the loan’s maturity date on June 23, 2021.	Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $2.50 per share or 90% of the lowest trading price over the previous 20 days. The loan is guaranteed by the Company’s Chief Executive Officer, but the lender may only enforce this guarantee after certain conditions have been met, specifically after (i) the occurrence of an Event of Default (as defined in the Note), (ii) the failure of the Company to cure the Default in 10 business days, and (iii) a failure by the Company to issue, or cause to be issued, shares of its common stock upon submission by the lender of a notice of conversion.
Debt instrument, convertible price per shares		$ 2.50
Debt instrument lowest trading price		90.00%

Summary of Changes in Convertib

Summary of Changes in Convertible Debt and Revolving Note Payable, Net of Unamortized Discounts (Details) - USD ($)	9 Months Ended	12 Months Ended
	Sep. 30, 2021	Dec. 31, 2020
Debt Disclosure [Abstract]
Balance at January 1,	$ 7,545,670
Issuance of convertible debt, face value	5,857,375
Deferred financing cost	(802,875)
Beneficial conversion feature on convertible note	(1,231,528)
Debt discount from shares and warrants issued with debt	(1,954,744)
Payments	(1,608,295)
Conversion of debt into equity	(1,305,455)
Accretion of interest and amortization of debt discount to interest expense	5,260,151
Balance at September 30,	11,760,299	$ 7,545,670
Less: current portion	11,760,299	$ 7,545,670
Convertible debt, long-term portion

Schedule of Merchant Agreements

Schedule of Merchant Agreements (Details) - USD ($)	9 Months Ended	12 Months Ended
	Sep. 30, 2021	Dec. 31, 2020
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Purchase Price	$ 700,000	$ 300,000
Purchased Amount	959,175	413,700
Outstanding Balance	210,318	248,968
Daily Payment Rate	7,013	2,709
Deferred Finance Fees	$ 8,850
Merchant Agreements Four [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date	Mar. 26, 2021
Purchase Price	$ 240,000
Purchased Amount	330,960
Outstanding Balance	20,775
Daily Payment Rate	2,364
Deferred Finance Fees
Merchant Agreements Five [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date	May 3, 2021
Purchase Price	$ 200,000
Purchased Amount	275,800
Outstanding Balance	51,470
Daily Payment Rate	1,970
Deferred Finance Fees	$ 5,000
Merchant Agreements Six [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date	Jun. 2, 2021
Purchase Price	$ 135,000
Purchased Amount	186,165
Outstanding Balance	61,657
Daily Payment Rate	1,400
Deferred Finance Fees	$ 1,350
Merchant Agreements Seven [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date	Jul. 6, 2021
Purchase Price	$ 125,000
Purchased Amount	166,250
Outstanding Balance	76,416
Daily Payment Rate	1,279
Deferred Finance Fees	$ 2,500
Merchant Agreements One [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date		Nov. 5, 2020
Purchase Price		$ 200,000
Purchased Amount		275,800
Outstanding Balance		163,955
Daily Payment Rate		1,724
Deferred Finance Fees
Merchant Agreements Two [Member]
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Inception Date		Nov. 19, 2020
Purchase Price		$ 100,000
Purchased Amount		137,900
Outstanding Balance		85,013
Daily Payment Rate		985
Deferred Finance Fees

Convertible Debt and Other De_3

Convertible Debt and Other Debt (Details Narrative) - USD ($)	Oct. 11, 2019	Oct. 01, 2019	Sep. 30, 2021	Sep. 30, 2020	Feb. 28, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020	Jun. 30, 2021	Apr. 16, 2021	Mar. 31, 2021
Short-term Debt [Line Items]
Proceeds from Convertible Debt						$ 5,054,500	$ 6,977,800
Debt Instrument, Convertible, Beneficial Conversion Feature						1,231,528
Convertible Debt			$ 11,760,299			11,760,299		$ 7,545,670
Debt Instrument, Unamortized Discount			2,692,163			2,692,163		3,948,167
Repayments of Convertible Debt						1,608,295	1,972,007
Debt Instrument, Fee Amount			8,850			8,850
Gain (Loss) on Extinguishment of Debt			$ (277,010)	$ (395,854)		$ (1,500,395)	$ (3,242,372)
Number of warrants issued			44,000			44,000
Warrants exercise price per share			$ 3.50			$ 3.50
Repayments of Debt						$ 1,608,295
Fair Value Adjustment of Warrants						$ 38,783
Stock Issued During Period, Shares, New Issues						56,067
Debt conversion principal amount						$ 110,000
Debt Instrument, Periodic Payment						$ 7,013		2,709
Small Business Administration [Member]
Short-term Debt [Line Items]
Debt Instrument, Term						5 years
Debt Instrument, Interest Rate, Stated Percentage			1.00%			1.00%
Debt Instrument, Face Amount			$ 367,038			$ 367,038
Debt Instrument, Decrease, Forgiveness						$ 367,039
Warrant [Member]
Short-term Debt [Line Items]
Warrants exercise price per share			$ 3.50			$ 3.50
Standstill and Forbearance Agreements [Member]
Short-term Debt [Line Items]
Convertible Debt										$ 1,100,000	$ 469,000,000
Debt Instrument, Fee Amount			$ 1,250,000			$ 1,250,000
Economic Injury Disaster Loan Program [Member]
Short-term Debt [Line Items]
Debt Instrument, Term						30 years
Debt Instrument, Interest Rate, Stated Percentage			3.75%			3.75%
Debt Instrument, Face Amount			$ 150,000			$ 150,000
Debt Instrument, Periodic Payment						731
One Lender [Member]
Short-term Debt [Line Items]
Convertible Debt			9,400,000			9,400,000
Lender [Member]
Short-term Debt [Line Items]
Convertible Debt			$ 14,500,000			$ 14,500,000
Lenders [Member]
Short-term Debt [Line Items]
Warrants and Rights Outstanding, Term			5 years			5 years
Warrants exercise price per share			$ 3.50			$ 3.50
Stock Issued During Period, Shares, New Issues						1,244,286
Lenders [Member] | Standstill and Forbearance Agreements [Member]
Short-term Debt [Line Items]
Debt Instrument, Face Amount									$ 1,570,000
Convertible Common Stock [Member]
Short-term Debt [Line Items]
Debt Instrument, Convertible, Conversion Price			$ 2.50			$ 2.50
Convertible Debt, Fair Value Disclosures			$ 1,954,744			$ 1,954,744
Minimum [Member]
Short-term Debt [Line Items]
Warrants and Rights Outstanding, Term			3 years			3 years
Minimum [Member] | Merchant Agreements [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage			9.30%			9.30%
Maximum [Member]
Short-term Debt [Line Items]
Warrants and Rights Outstanding, Term			5 years			5 years
Warrants exercise price per share			$ 5			$ 5
Maximum [Member] | Merchant Agreements [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage			14.00%			14.00%
Convertible Debt [Member]
Short-term Debt [Line Items]
Proceeds from Convertible Debt						$ 5,857,375
Debt Instrument, Convertible, Beneficial Conversion Feature						1,231,528
Amortization of Debt Discount (Premium)						5,260,151
Debt Instrument, Unamortized Discount			$ 2,692,163			$ 2,692,163
Convertible Debt [Member] | Minimum [Member]
Short-term Debt [Line Items]
Debt Instrument, Term						6 months
Debt Instrument, Interest Rate, Stated Percentage			10.00%			10.00%
Convertible Debt [Member] | Maximum [Member]
Short-term Debt [Line Items]
Debt Instrument, Term						12 months
Debt Instrument, Interest Rate, Stated Percentage			18.00%			18.00%
Five Notes [Member] | Standstill and Forbearance Agreements [Member]
Short-term Debt [Line Items]
Repayments of Convertible Debt			$ 741,500
Five Notes [Member] | Three Lenders [Member] | Standstill and Forbearance Agreements [Member]
Short-term Debt [Line Items]
Repayments of Convertible Debt			$ 827,500
New Loan [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage			10.00%			10.00%
Debt Instrument, Interest Rate Terms						According to ASC 470, an exchange of debt instruments between or a modification of a debt instrument by a debtor and a creditor in a nontroubled debt situation is deemed to have been accomplished with debt instruments that are substantially different if the present value of the cash flows under the terms of the new debt instrument is at least 10 percent different from the present value of the remaining cash flows under the terms of the original instrument. If the terms of a debt instrument are changed or modified and the cash flow effect on a present value basis is less than 10 percent, the debt instruments are not considered to be substantially different and will be accounted for as modifications.
Gain (Loss) on Extinguishment of Debt						$ 1,900,000
Non-Convertible Loans [Member] | Private Investor [Member]
Short-term Debt [Line Items]
Debt Instrument, Term	1 month
Debt Instrument, Interest Rate, Stated Percentage	2.00%
Debt Instrument, Face Amount			$ 691,500			$ 691,500
Proceeds from Loans	$ 25,000				$ 966,500			$ 463,500
Non-Convertible Loans [Member] | Private Investor [Member] | Warrant [Member]
Short-term Debt [Line Items]
Number of warrants issued			17,000			17,000		150,000
Warrants and Rights Outstanding, Term			5 years			5 years		5 years
Warrants exercise price per share			$ 3.50			$ 3.50		$ 3.50
Repayments of Debt								$ 275,000
Fair Value Adjustment of Warrants								$ 185,660
Non-Convertible Loans [Member] | Private Investor [Member] | Series AA Preferred Stock [Member]
Short-term Debt [Line Items]
Stock Issued During Period, Shares, New Issues						17
Non-Convertible Loans [Member] | Holder [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage		10.00%
Proceeds from Loans		$ 170,000
Stock Issued During Period, Shares, New Issues		1,200
Short-term Non-Convertible Loan [Member]
Short-term Debt [Line Items]
Repayments of Debt						$ 256,600
Proceeds from Short-term Debt						194,600
Debt conversion principal amount						66,000
Debt conversion interest amount						$ 107,625
Short-term Non-Convertible Loan [Member] | Series AA Preferred Stock [Member]
Short-term Debt [Line Items]
Number of warrants issued			69,450			69,450
Warrants and Rights Outstanding, Term			5 years			5 years
Warrants exercise price per share			$ 3.50			$ 3.50
Stock Issued During Period, Shares, New Issues						69.5
Short-term Non-Convertible Loan [Member] | Minimum [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage			15.00%			15.00%
Short-term Non-Convertible Loan [Member] | Maximum [Member]
Short-term Debt [Line Items]
Debt Instrument, Interest Rate, Stated Percentage			10.00%			10.00%

Schedule of Concerning Options

Schedule of Concerning Options and Warrants Outstanding and Exercisable (Details)	9 Months Ended
	Sep. 30, 2021$ / sharesshares
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shares, Beginning balance	15,790,603
Exercisable, Beginning balance	15,302,830
Shares, Granted	2,188,366
Shares, Exercised	(208,911)
Shares, Expired	(161,998)
Shares, Ending balance	17,608,060
Exercisable, Beginning balance	17,313,673
Stock Options [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shares, Beginning balance	1,355,901
Weighted average price per share, Beginning balance | $ / shares	$ 0.69
Shares, Granted	24,000
Weighted average price per share, Granted | $ / shares	$ 2.17
Shares, Exercised	(21,411)
Weighted average price per share, Exercised | $ / shares	$ 0.69
Shares, Expired	(16,000)
Weighted average price per share, Expired | $ / shares	$ 0.69
Shares, Ending balance	1,342,490
Weighted average price per share, Ending balance | $ / shares	$ 0.72
Warrant [Member]
Accumulated Other Comprehensive Income (Loss) [Line Items]
Shares, Beginning balance	14,434,702
Weighted average price per share, Beginning balance | $ / shares	$ 3.50
Shares, Granted	2,164,366
Weighted average price per share, Granted | $ / shares	$ 3.59
Shares, Exercised	(187,500)
Weighted average price per share, Exercised | $ / shares	$ 3.50
Shares, Expired	(145,998)
Weighted average price per share, Expired | $ / shares	$ 3.50
Shares, Ending balance	16,265,570
Weighted average price per share, Ending balance | $ / shares	$ 3.50

Schedule of Loans Obligated to

Schedule of Loans Obligated to Issue Shares (Details) - USD ($)	Dec. 23, 2020	Sep. 30, 2021
Short-term Debt [Line Items]
Defined Frequency	we are obligated to issue 100,000 warrants if the loan is not repaid before January 23, 2021 and an additional 10,000 shares of common stock and 100,000 warrants if the loan is not repaid before February 23, 2021. We are also obligated to issue 10,000 shares of common stock and 200,000 warrants if the loan is not repaid before March 23, 2021. During the nine months ended September 30, 2021 the Company issued 400,000 warrants to this lender ($3.50 exercise price and five-year term) with a fair value of $600,298. The Company is also obligated to issue 10,000 shares of common stock to this lender every 31 days up to the loan’s maturity date on June 23, 2021.	Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $2.50 per share or 90% of the lowest trading price over the previous 20 days. The loan is guaranteed by the Company’s Chief Executive Officer, but the lender may only enforce this guarantee after certain conditions have been met, specifically after (i) the occurrence of an Event of Default (as defined in the Note), (ii) the failure of the Company to cure the Default in 10 business days, and (iii) a failure by the Company to issue, or cause to be issued, shares of its common stock upon submission by the lender of a notice of conversion.
Loans 1 [Member]
Short-term Debt [Line Items]
Loan Issuance Date		Jul. 21, 2020
Loan Principal		$ 115,000
Shares Issuable		5,000
Defined Date		Sep. 30, 2020
Defined Frequency		Monthly
Loans 2 [Member]
Short-term Debt [Line Items]
Loan Issuance Date		Sep. 21, 2020
Loan Principal		$ 345,000
Shares Issuable		12,500
Defined Date		Nov. 16, 2020
Defined Frequency		Weekly
Loans 3 [Member]
Short-term Debt [Line Items]
Loan Issuance Date		Sep. 23, 2020
Loan Principal		$ 115,000
Shares Issuable		12,500
Defined Date		Dec. 1, 2020
Defined Frequency		Weekly
Loans 4 [Member]
Short-term Debt [Line Items]
Loan Issuance Date		Sep. 25, 2020
Loan Principal		$ 115,000
Shares Issuable		12,500
Defined Date		Dec. 1, 2020
Defined Frequency		Weekly
Loans 5 [Member]
Short-term Debt [Line Items]
Loan Issuance Date		Oct. 22, 2020
Loan Principal		$ 115,000
Shares Issuable		12,500
Defined Date		Dec. 1, 2020
Defined Frequency		Weekly

Stockholders_ Deficit (Details

Stockholders’ Deficit (Details Narrative) - USD ($)	Dec. 23, 2020	Sep. 30, 2021	Jun. 30, 2021	Mar. 31, 2021	Sep. 30, 2020	Jun. 30, 2020	Mar. 31, 2020	Sep. 30, 2021	Sep. 30, 2020	Dec. 31, 2020	Dec. 12, 2013
Class of Stock [Line Items]
Number of warrants issued		1,558,266						1,558,266
Exercise price of warrant		$ 3.50						$ 3.50
Common stock, shares outstanding under the plan		17,608,060						17,608,060		15,790,603
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Amount		$ 178,801						$ 178,801
Share-based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition								1 year 5 months 4 days
Share Price		$ 2.50						$ 2.50
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Intrinsic Value		$ 1,897,066						$ 1,897,066
Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price		$ 0.69						$ 0.69
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number		17,313,673						17,313,673		15,302,830
Shares issued								56,067
Loan issue description	we are obligated to issue 100,000 warrants if the loan is not repaid before January 23, 2021 and an additional 10,000 shares of common stock and 100,000 warrants if the loan is not repaid before February 23, 2021. We are also obligated to issue 10,000 shares of common stock and 200,000 warrants if the loan is not repaid before March 23, 2021. During the nine months ended September 30, 2021 the Company issued 400,000 warrants to this lender ($3.50 exercise price and five-year term) with a fair value of $600,298. The Company is also obligated to issue 10,000 shares of common stock to this lender every 31 days up to the loan’s maturity date on June 23, 2021.							Loan is not convertible until 180 days from the date of issuance of the Note and following an Event of Default will be convertible at the lesser of $2.50 per share or 90% of the lowest trading price over the previous 20 days. The loan is guaranteed by the Company’s Chief Executive Officer, but the lender may only enforce this guarantee after certain conditions have been met, specifically after (i) the occurrence of an Event of Default (as defined in the Note), (ii) the failure of the Company to cure the Default in 10 business days, and (iii) a failure by the Company to issue, or cause to be issued, shares of its common stock upon submission by the lender of a notice of conversion.
Number of restricted stock issued									85,000
[custom:IssuanceOfCommonStockForInterestPaidinkind]		$ 2,153,947	$ 1,432,671	$ 2,021,780	$ 82,566		$ 60,560	$ 5,600,000
Stock Issued During Period, Shares, Issued for Services								248,200	25,000
Stock Issued During Period, Value, Issued for Services		341,000		238,512		$ 87,963			$ 87,963
Stock Issued During Period, Shares, Conversion of Convertible Securities								1,035,996	709,788
Stock Issued During Period, Value, Conversion of Convertible Securities				$ 118,000	537,894	1,292,649		$ 2,589,990	$ 1,800,000
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period								208,911
[custom:IssuanceOfCommonStockForDividendsPaidinkind]		$ 114,298	$ 114,298		44,626	$ 176,748
Adjustments to Additional Paid in Capital, Equity Component of Convertible Debt								$ 551,198
[custom:NumberOfStockIssuedForWarrantExercise]								36,290
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right		44,000						44,000
Gain (Loss) on Extinguishment of Debt		$ (277,010)			$ (395,854)			$ (1,500,395)	(3,242,372)
Stock Issued During Period, Value, Restricted Stock Award, Gross									$ 147,775
Warrant term								5 years
Debt conversion amount								$ 110,000
Debt conversion, shares								44
Fair value of warrants								$ 38,783
Non Convertible Debt [Member]
Class of Stock [Line Items]
Gain (Loss) on Extinguishment of Debt								$ 23,004
Minimum [Member]
Class of Stock [Line Items]
Warrants term		3 years						3 years
Maximum [Member]
Class of Stock [Line Items]
Exercise price of warrant		$ 5						$ 5
Warrants term		5 years						5 years
Lenders [Member]
Class of Stock [Line Items]
Number of warrants issued		400,000						400,000
Exercise price of warrant		$ 3.50						$ 3.50
Shares issued								1,244,286
Issuance of common stock for interest paid-in-kind, shares								200,000
Warrants term		5 years						5 years
Fair value of warrants		$ 600,298						$ 600,298
[custom:IssuanceOfCommonStockForInterestPaidinkind]								2,431,182
Stock Issued During Period, Value, Issued for Services								579,512
Stock Issued During Period, Value, Conversion of Convertible Securities								$ 2,000,000
Warrants issued								400,000
Accredited Investors And Consultants [Member]
Class of Stock [Line Items]
Number of restricted stock issued									1,202,118
Stock Issued During Period, Value, Restricted Stock Award, Gross									$ 2,800,000
Share-based Payment Arrangement, Option [Member]
Class of Stock [Line Items]
Common stock, shares outstanding under the plan			1,342,490
Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price		$ 0.72						$ 0.72
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term								7 years 11 months 15 days
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercisable, Number		1,048,103						1,048,103
Two Thousand Thirteen Equity Incentive Plan [Member]
Class of Stock [Line Items]
Common stock, shares outstanding under the plan		1,342,490						1,342,490
Two Thousand Thirteen Equity Incentive Plan [Member]
Class of Stock [Line Items]
Common stock reserved for stock option plan											3,000,000
Series AA Preferred Stock [Member] | Non Convertible Debt [Member]
Class of Stock [Line Items]
Shares issued								200
Stock Options [Member]
Class of Stock [Line Items]
Common stock, shares outstanding under the plan		1,342,490						1,342,490		1,355,901
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period								21,411
Common Stock [Member]
Class of Stock [Line Items]
Shares issued					178,778			347,650
Issuance of common stock for interest paid-in-kind, shares		788,200	720,610	922,372	46,021	42,510	38,521
[custom:IssuanceOfCommonStockForInterestPaidinkind]		$ 7,883	$ 7,206	$ 9,224	$ 460		$ 385
Stock Issued During Period, Shares, Issued for Services		135,800		112,400		25,000
Stock Issued During Period, Value, Issued for Services		$ 1,358		$ 1,124		$ 250
Stock Issued During Period, Shares, Conversion of Convertible Securities				47,200	299,042	410,746
Stock Issued During Period, Value, Conversion of Convertible Securities				$ 472	$ 2,990	$ 4,107
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period				21,411
[custom:IssuanceOfCommonStockForDividendsPaidinkind]			$ 560		$ 232	$ 644
Warrant [Member]
Class of Stock [Line Items]
Number of warrants issued		4,168,531						4,168,531
Exercise price of warrant		$ 3.50						$ 3.50
Common stock, shares outstanding under the plan		16,265,570						16,265,570		14,434,702
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period								187,500
Number of shares converted value								$ 5,600,000
Warrant [Member] | Non Convertible Debt [Member]
Class of Stock [Line Items]
Exercise price of warrant		$ 3.50						$ 3.50
Warrants term		5 years						5 years
Fair value of warrants		$ 245,635						$ 245,635
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right		200,100						200,100
Warrant [Member] | Minimum [Member]
Class of Stock [Line Items]
Warrant term								3 years
Warrant [Member] | Maximum [Member]
Class of Stock [Line Items]
Warrant term								5 years
Securities Purchase Agreement [Member] | Series AA Preferred Stock [Member] | Accredited [Member]
Class of Stock [Line Items]
Sale of Stock, Number of Shares Issued in Transaction								406
Conversion of Stock, Shares Converted								1,000
Common Stock, No Par Value		$ 0.01						$ 0.01
Sale of Stock, Consideration Received on Transaction								$ 1,015,000
Number of warrants issued		406,000						406,000
Exercise price of warrant		$ 3.50						$ 3.50
Stock Options Issuance [Member]
Class of Stock [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Net of Forfeitures								24,000
Shares Issued, Value, Share-based Payment Arrangement, after Forfeiture								$ 49,135
Share-based Payment Arrangement, Option, Exercise Price Range, Outstanding, Weighted Average Exercise Price		$ 2.17						$ 2.17
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period								3 years
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term								10 years
Debt Settlement [Member]
Class of Stock [Line Items]
Number of restricted stock issued								10,000
Debt Extention And Interest Payments [Member]
Class of Stock [Line Items]
Number of restricted stock issued									315,830
Stock Issued During Period, Value, Restricted Stock Award, Gross									$ 616,900
Settlement Accurued Liability [Member]
Class of Stock [Line Items]
Number of restricted stock issued									66,500
Stock Issued During Period, Value, Restricted Stock Award, Gross									$ 127,855
Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		1,000,000						1,000,000
Convertible preferred stock, par value		$ 0.01						$ 0.01
Convertible preferred stock, shares issued			1,000,000
Series A Junior Participating Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		20,000						20,000
Convertible preferred stock, shares issued		0						0
Preferred stock, shares outstanding		0						0
Series A Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		313,960						313,960
Convertible preferred stock, shares issued		0						0
Preferred stock, shares outstanding		0						0
Series B Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		279,256						279,256
Convertible preferred stock, shares issued		0						0
Preferred stock, shares outstanding		0						0
Series C Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		88,098						88,098
Convertible preferred stock, shares issued		0						0
Preferred stock, shares outstanding		0						0
Series D Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		850						850		850
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		300						300		300
Preferred stock, shares outstanding		300						300		300
Series E Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		500						500
Convertible preferred stock, shares issued		0						0
Preferred stock, shares outstanding		0						0
Series G Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		240,000						240,000		240,000
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		80,570						80,570		80,570
Preferred stock, shares outstanding		80,570						80,570		80,570
Series H Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		10,000						10,000		10,000
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		10,000						10,000		10,000
Preferred stock, shares outstanding		10,000						10,000		10,000
Series H Two Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		21						21
Series J Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		6,250						6,250		6,250
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		3,458						3,458		3,458
Preferred stock, shares outstanding		3,458						3,458		3,458
Series K Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		15,000						15,000		15,000
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		6,880						6,880		6,880
Preferred stock, shares outstanding		6,880						6,880		6,880
Series AA Convertible Preferred Stock [Member]
Class of Stock [Line Items]
Convertible preferred stock, authorized		10,000						10,000		10,000
Convertible preferred stock, par value		$ 0.01						$ 0.01		$ 0.01
Convertible preferred stock, shares issued		8,649						8,649		8,043
Preferred stock, shares outstanding		8,649						8,649		8,043
Common Stock Dividends, Shares									87,518
Dividends, Common Stock, Cash									$ 221,374

Subsequent Events (Details Narr

Subsequent Events (Details Narrative) - USD ($)	1 Months Ended	9 Months Ended
	Nov. 11, 2021	Sep. 30, 2021	Sep. 30, 2020
Subsequent Event [Line Items]
Common stock issued for debt settlement, shares		56,067
Debt Conversion, Converted Instrument, Shares Issued		44
Repayments of Related Party Debt		$ 256,600	$ 15,000
Stock Issued During Period, Shares, Issued for Services		248,200	25,000
Lenders [Member]
Subsequent Event [Line Items]
Common stock issued for debt settlement, shares		1,244,286
Subsequent Event [Member]
Subsequent Event [Line Items]
Proceeds from Loans	$ 379,500
Common stock issued for debt settlement, shares	52,000
Debt Conversion, Converted Instrument, Rate	2.50%
Debt Instrument, Interest Rate, Stated Percentage	10.00%
Debt Instrument, Term	12 months
Repayments of Short-term Debt	$ 100,000
Conversion of Stock, Shares Issued	15,000
Due to Related Parties	$ 15,000
Repayments of Related Party Debt	$ 23,000
Subsequent Event [Member] | Lenders [Member]
Subsequent Event [Line Items]
Common stock issued for debt settlement, shares	100,000
Subsequent Event [Member] | Convertible Debt [Member]
Subsequent Event [Line Items]
Common stock issued for debt settlement, shares	160,000
Debt Conversion, Converted Instrument, Shares Issued	13,000
Stock Issued During Period, Shares, Issued for Services	85,000