Spectrum Pharmaceuticals (SPPI) 10-Q 6 May 16 2016 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2016	Apr. 29, 2016
Document And Entity Information [Abstract]
Document Type	10-Q
Amendment Flag	false
Document Period End Date	Mar. 31, 2016
Document Fiscal Year Focus	2,016
Document Fiscal Period Focus	Q1
Trading Symbol	SPPI
Entity Registrant Name	SPECTRUM PHARMACEUTICALS INC
Entity Central Index Key	831,547
Current Fiscal Year End Date	--12-31
Entity Filer Category	Accelerated Filer
Entity Common Stock, Shares Outstanding		69,220,610

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Current assets:
Cash and cash equivalents	$ 132,306	$ 139,741
Marketable securities	246	245
Accounts receivable, net of allowance for doubtful accounts of $15 and $120, respectively	19,248	30,384
Other receivables	15,175	12,572
Inventories	3,155	4,176
Prepaid expenses and other assets	2,352	3,507
Total current assets	172,482	190,625
Property and equipment, net of accumulated depreciation	810	918
Intangible assets, net of accumulated amortization and impairment charges	184,753	190,335
Goodwill	18,044	17,960
Other assets	25,304	19,211
Total assets	401,393	419,049
Current liabilities:
Accounts payable and other accrued liabilities	47,503	56,539
Accrued payroll and benefits	4,555	8,188
Deferred revenue	1,312	6,130
Drug development liability	156	259
Acquisition-related contingent obligations	6,000	5,227
Total current liabilities	59,526	76,343
Drug development liability, less current portion	14,354	14,427
Deferred revenue, less current portion	1,596	383
Acquisition-related contingent obligations, less current portion	1,708	1,439
Deferred tax liability	6,849	6,779
Other long-term liabilities	8,109	7,444
Convertible senior notes	100,933	99,377
Total liabilities	$ 193,075	$ 206,192
Commitments and contingencies
Stockholders’ equity:
Preferred stock	$ 0	$ 0
Common stock, $0.001 par value; 175,000,000 shares authorized; 68,942,042 and 68,228,935 shares issued and outstanding at March 31, 2016 and December 31, 2015, respectively	68	68
Additional paid-in capital	555,056	552,108
Accumulated other comprehensive loss	(3,485)	(5,319)
Accumulated deficit	(343,444)	(334,123)
Total stockholders’ equity	208,318	212,857
Total liabilities and stockholders’ equity	401,393	419,049
Series B junior participating preferred stock [Member]
Stockholders’ equity:
Preferred stock	0	0
Series E Convertible Voting Preferred Stock [Member]
Stockholders’ equity:
Preferred stock	$ 123	$ 123

Condensed Consolidated Balance3

Condensed Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Allowance for doubtful accounts receivable	$ 15	$ 120
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	5,000,000	5,000,000
Common stock, par value ($ per share)	$ 0.001	$ 0.001
Common stock, shares authorized	175,000,000	175,000,000
Common stock, shares issued	68,942,042	68,228,935
Common stock, shares outstanding	68,942,042	68,228,935
Series B junior participating preferred stock [Member]
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	1,500,000	1,500,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Series E Convertible Voting Preferred Stock [Member]
Preferred stock, par value ($ per share)	$ 0.001	$ 0.001
Preferred stock, stated value ($ per share)	$ 10,000	$ 10,000
Preferred stock, shares authorized	2,000	2,000
Preferred stock, shares issued	20	20
Preferred stock, shares outstanding	20	20
Convertible preferred shares	40,000	40,000
Preferred stock, liquidation value	$ 240	$ 240

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenues:
Product sales, net	$ 35,241	$ 38,413
License fees and service revenue	8,625	205
Total revenues	43,866	38,618
Operating costs and expenses:
Cost of product sales (excludes amortization and impairment charges of intangible assets)	5,604	7,071
Cost of service revenue	1,282	0
Selling, general and administrative	21,962	23,335
Research and development	15,462	15,851
Amortization and impairment charges of intangible assets	5,839	14,022
Total operating costs and expenses	50,149	60,279
Loss from operations	(6,283)	(21,661)
Other (expense) income:
Interest expense, net	(2,340)	(2,228)
Change in fair value of contingent consideration related to acquisitions	(1,042)	(500)
Other income (expense), net	278	(1,035)
Total other expenses	(3,104)	(3,763)
Loss before income taxes	(9,387)	(25,424)
Benefit (provision) for income taxes	66	(138)
Net loss	$ (9,321)	$ (25,562)
Net loss per share:
Basic and diluted ($ per share)	$ (0.14)	$ (0.39)
Weighted average shares outstanding:
Basic and diluted (shares)	65,597,261	64,880,677

Condensed Consolidated Stateme5

Condensed Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Statement of Comprehensive Income [Abstract]
Net loss	$ (9,321)	$ (25,562)
Other comprehensive (loss) income, net of income tax:
Unrealized gain on available-for-sale securities	1,361	779
Foreign currency translation adjustments	473	(2,006)
Other comprehensive income (loss)	1,834	(1,227)
Total comprehensive loss	$ (7,487)	$ (26,789)

Condensed Consolidated Stateme6

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Cash Flows From Operating Activities:
Net loss	$ (9,321)	$ (25,562)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation and amortization	6,008	7,017
Stock-based compensation	3,177	2,462
Accretion of debt discount, recorded to interest expense on 2018 Convertible Notes (Note 14)	1,385	1,270
Amortization of deferred financing costs, recorded to interest expense on 2018 Convertible Notes (Note 14)	171	162
Bad debt (recovery) expense	(16)	44
Impairment of intangible assets (Note 3(f))	0	7,160
Unrealized foreign currency exchange loss	14	1,128
Research and development expense recognized for the value of stock issued in connection with APAZIQUONE milestone (Note 16(b)(ix))	111	0
Change in fair value of contingent consideration related to Talon and EVOMELA acquisitions (Note 9)	1,042	500
Changes in operating assets and liabilities:
Accounts receivable, net	11,186	1,864
Other receivables	(2,500)	(2,399)
Inventories	(2,741)	121
Prepaid expenses	1,154	436
Deferred tax assets	0	(235)
Other assets	(824)	(404)
Accounts payable and other accrued obligations	(9,074)	(2,778)
Accrued payroll and benefits	(3,641)	(4,056)
Drug development liability	(175)	(666)
Deferred revenue	(3,768)	7,555
Deferred tax liability	70	239
Other long-term liabilities	659	855
Net cash used in operating activities	(7,083)	(5,287)
Cash Flows From Investing Activities:
Redemption of mutual funds	(1)	0
Purchase of equity securities (Note 10)	(17)	0
Purchases of property and equipment	(61)	(78)
Net cash used in investing activities	(79)	(78)
Cash Flows From Financing Activities:
Proceeds from exercise of stock options	51	404
Purchase and retirement of restricted stock to satisfy employees' tax liability at vesting	(392)	(262)
Net cash (used in) provided by financing activities	(341)	142
Effect of exchange rates on cash and equivalents	68	(1,354)
Net decrease in cash and cash equivalents	(7,435)	(6,577)
Cash and cash equivalents—beginning of period	139,741	129,942
Cash and cash equivalents—end of period	132,306	123,365
Supplemental disclosure of cash flow information:
Cash paid for income taxes	9	331
Cash paid for interest	$ 0	$ 0

Description of Business, Basis

Description of Business, Basis of Presentation, and Operating Segment	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Description of Business, Basis of Presentation, and Operating Segment	DESCRIPTION OF BUSINESS, BASIS OF PRESENTATION, AND OPERATING SEGMENT (a) Description of Business Spectrum Pharmaceuticals, Inc. (“Spectrum”, the “Company”, “we”, “our”, or “us”) is a biotechnology company, with a primary strategy comprised of acquiring, developing, and commercializing a broad and diverse pipeline of late-stage clinical and commercial products. In addition to an in-house clinical development organization with regulatory and data management capabilities, we have established a commercial infrastructure for our marketed products. Currently, we market six approved oncology/hematology products that target different types of non-Hodgkin's lymphoma ("NHL"), advanced metastatic colorectal cancer, acute lymphoblastic leukemia ("ALL"), and multiple myeloma ("MM"). We also have three drugs in late-stage development: • SPI-2012 for chemotherapy-induced neutropenia in patients with breast cancer. • APAZIQUONE for immediate intravesical instillation in post-transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer. • POZIOTINIB, a novel pan-HER inhibitor used in the treatment of patients with breast cancer. (b) Basis of Presentation Interim Financial Statements The interim financial data as of March 31, 2016 and 2015 is unaudited, and is not necessarily indicative of our operating results for a full year. In the opinion of our management, the interim data includes normal and recurring adjustments necessary for a fair presentation of our financial results for the three months ended March 31, 2016 and 2015 . Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with generally accepted accounting principles in the United States of America (“GAAP”) have been condensed or omitted pursuant to U.S. Securities and Exchange Commission (“SEC”) rules and regulations relating to interim financial statements. The December 31, 2015 balances reported herein are derived from the audited Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2015 . The accompanying Condensed Consolidated Financial Statements should be read in conjunction with our audited Consolidated Financial Statements and Notes thereto included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 , filed with the SEC on March 14, 2016. Principles of Consolidation The accompanying Condensed Consolidated Financial Statements have been prepared in accordance with GAAP and with the rules and regulations of the U.S. Securities and Exchange Commission ("SEC"). These financial statements include the financial position, results of operations, and cash flows of Spectrum and its subsidiaries, all of which are wholly-owned (except for SPC, as discussed below). All inter-company accounts and transactions among these legal entities have been eliminated in consolidation. Variable Interest Entity We own fifty -percent of Spectrum Pharma Canada (“SPC”), a legal entity organized in Quebec, Canada in January 2008. Certain of our drug clinical studies are conducted through this “variable interest entity” (as defined under applicable GAAP) and we fund all of SPC’s operating costs. Since we carry the full risks and rewards of SPC, we meet the applicable GAAP criteria as being its “primary beneficiary.” Accordingly, SPC’s balance sheets and statements of operations are included in our Condensed Consolidated Financial Statements as if it were a wholly-owned subsidiary for all periods presented. (c) Operating Segment We operate in one reportable operating segment that is focused exclusively on developing and commercializing oncology and hematology drug products. For the three months ended March 31, 2016 and 2015 , all of our revenue and related expenses were solely attributable to these activities. Substantially all of our assets (excluding our cash held in certain foreign bank accounts and our ZEVALIN distribution rights for the Ex-U.S. territory) are held in the U.S.

Use of Estimates and Summary of

Use of Estimates and Summary of Significant Accounting Policies	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Use of Estimates and Summary of Significant Accounting Policies	USE OF ESTIMATES AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES The preparation of financial statements in conformity with GAAP requires our management to make informed estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, and expenses. However, actual values may materially differ, since estimates are inherently uncertain. On an on-going basis, our management evaluates its estimates and assumptions, including those related to (i) gross-to-net revenue adjustments; (ii) the timing of revenue recognition; (iii) the collectability of customer accounts; (iv) whether the cost of inventories can be recovered; (v) the fair value of goodwill and intangible assets; (vi) the realization of tax assets and estimates of tax liabilities; (vii) the likelihood of payment and value of contingent liabilities; (viii) the fair value of investments; (ix) the valuation of stock options and the periodic expense recognition of stock-based compensation; and (x) the potential outcome of ongoing or threatened litigation. The estimates and assumptions that most significantly impact the presented amounts within these accompanying Condensed Consolidated Financial Statements are further described below: (i) Revenue Recognition (a) Product Sales : We sell our products to wholesalers/distributors (i.e., our customers), except for our U.S. sales of ZEVALIN in which case the end-user (i.e. clinic or hospital) is our customer. Our wholesalers/distributors in turn sell our products directly to clinics, hospitals, and private oncology-based practices. Revenue from our product sales is recognized when title and risk of loss have transferred to our customer, and the following additional criteria are met: (1) appropriate evidence of a binding arrangement exists with our customer; (2) price is substantially fixed and determinable; (3) collection from our customer is reasonably assured; (4) our customer’s obligation to pay us is not contingent on resale of the product; (5) we do not have significant continued performance obligations to our customer; and (6) we have a reasonable basis to estimate returns. Our gross revenue is reduced by our gross-to-net (“GTN”) estimates each period, resulting in our reported “product sales, net” in the accompanying Condensed Consolidated Statements of Operations. We defer revenue recognition in full if these estimates are not reasonably determinable at the time of sale. These estimates are based upon information received from external sources (such as written and oral information obtained from our customers with respect to their period-end inventory levels, and their sales to end-users during the period), in combination with management’s informed judgments. Due to the inherent uncertainty of estimates, the actual amount we incur may be materially different than our GTN estimates, and require prospective revenue adjustments in periods after the initial sale was recorded. Our GTN estimates are comprised of the following categories: Product Returns Allowances : Our FUSILEV, MARQIBO, and BELEODAQ customers are permitted to return purchased product beginning at its expiration date, and within six months thereafter. Returned product is generally not resold. Returns for expiry of ZEVALIN and FOLOTYN are not contractually, or customarily, allowed. We estimate expected returns based on our historical return rates. Government Chargebacks : Our products are subject to pricing limits under certain federal government programs (e.g., Medicare and 340B Drug Pricing Program). Qualifying entities (i.e., end-users) purchase product from our customers at their qualifying discounted price. The chargeback amount we incur represents the difference between our contractual sales price to our customer, and the end-user’s applicable discounted purchase price under the government program. There may be significant lag time between our reported net product sales and our receipt of corresponding government chargeback claims from our customers. Prompt Pay Discounts : Discounts for prompt payment are estimated at the time of sale, based on our eligible customers’ prompt payment history and the contractual discount percentage. Commercial Rebates : Commercial rebates are based on (i) our estimates of end-user purchases through a group purchasing organization ("GPO"), (ii) the corresponding contractual rebate percentage tier we expect each GPO to achieve, and (iii) our estimates of the impact of any prospective rebate program changes made by us. Medicaid Rebates : Our products are subject to state government-managed Medicaid programs, whereby rebates are issued to participating state governments. These rebates arise when a patient treated with our product is covered under Medicaid, resulting in a discounted price for our product under the applicable Medicaid program. Our Medicaid rebate accrual calculations require us to project the magnitude of our sales, by state, that will be subject to these rebates. There is a significant time lag in us receiving rebate notices from each state (generally several months or longer after our sale is recognized). Our estimates are based on our historical claim levels by state, as supplemented by management’s judgment. Distribution, Data, and GPO Administrative Fees : Distribution, data, and GPO administrative fees are paid to authorized wholesalers/distributors of our products (except for U.S. sales of ZEVALIN) for various commercial services, including: contract administration, inventory management, delivery of end-user sales data, and product returns processing. These fees are based on a contractually-determined percentage of our applicable sales. (b) License Fees : We recognize revenue for our licensing of intellectual property to third-parties (out-licenses), based on the contractual terms of each agreement and our application of pertinent GAAP. This revenue may be associated with upfront license fees, milestone payments from our licensees’ sales or regulatory achievements, and royalties from our licensees’ sales in applicable territories. (c) Service Revenue : We receive fees from third-parties under certain arrangements for our sales and marketing services, research and development activities, clinical trial management, and supply chain services. Payment may be triggered by contractual fixed payment schedules, the successful completion of a phase of development, results from a clinical trial, regulatory approval events, or completion of product delivery in our capacity as an agent in such arrangement. We recognize revenue when the corresponding milestone is achieved, or the revenue is otherwise earned and due to us through our on-going activities. (d) New Revenue Recognition Standard : On April 1, 2015, the FASB voted for a one-year deferral of the effective date of the new revenue recognition standard, ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606) (“ASU 2014-09”). ASU 2014-09 is now effective for us beginning January 1, 2018, requiring revenue recognition in a manner that reasonably reflects the delivery of our goods or services to customers in return for expected consideration. To achieve this core principle, the guidance provides the following steps: (1) identify the contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when (or as) the entity satisfies a performance obligation. We intend to apply the cumulative effect transition method of ASU 2014-09, and we continue to evaluate the impact of this new standard on our current revenue recognition models for product sales , license fees , and service revenue , as described above. (ii) Cash and Equivalents Our cash and equivalents consist of bank deposits and highly liquid investments with maturities of three months or less from the purchase date. (iii) Marketable Securities Our marketable securities consist of our holdings in mutual funds and bank certificates of deposit. Since we classify these securities as “available-for-sale” under applicable GAAP, any unrealized gains or losses from their change in value is reflected in “unrealized gain on available-for-sale securities” on the accompanying Condensed Consolidated Statements of Comprehensive Loss. Realized gains and losses on available-for-sale securities are included in “other income (expense), net” on the accompanying Condensed Consolidated Statements of Operations. (iv) Accounts Receivable Our accounts receivables are derived from our product sales and license fees (our service revenue is recorded in "other receivables"), and do not bear interest. The allowance for doubtful accounts is management’s best estimate of the amount of probable credit losses in our existing accounts receivable. Account balances are charged off against the allowance after appropriate collection efforts are exhausted. (v) Inventories We value our inventory at the lower of (i) the actual cost of its purchase or manufacture, or (ii) its current market value. Inventory cost is determined on the first-in, first-out method ("FIFO"). We regularly review our inventory quantities in process of manufacture and on hand. When appropriate, we record a provision for obsolete and excess inventory to derive its new cost basis, which takes into account our sales forecast by product and corresponding expiry dates. Direct and indirect manufacturing costs related to the production of inventory prior to U.S. Food and Drug Administration ("FDA") approval are expensed through “research and development,” rather than being capitalized to inventory cost. (vi) Property and Equipment Our property and equipment is stated at historical cost, and is depreciated on a straight-line basis over an estimated useful life that corresponds with its designated asset category. We evaluate the recoverability of “long-lived assets” (which includes property and equipment) whenever events or changes in circumstances in our business indicate that the asset’s carrying amount may not be recoverable through on-going operations. (vii) Goodwill and Intangible Assets Our goodwill represents the excess of our business acquisition cost over the estimated fair value of the net assets acquired in the corresponding transaction. Goodwill has an indefinite accounting life and is therefore not amortized. Instead, goodwill is evaluated for impairment on an annual basis (as of each October 1 st ), unless we identify impairment indicators that would require earlier testing. We evaluate the recoverability of indefinite-lived intangible assets at least annually, or whenever events or changes in our business indicate that an intangible asset’s (whether indefinite or definite-lived) carrying amount may not be recoverable. Such circumstances could include, but are not limited to the following: (a) a significant decrease in the market value of an asset; (b) a significant adverse change in the extent or manner in which an asset is used; or (c) an accumulation of costs significantly in excess of the amount originally expected for the acquisition of an asset. Intangible assets with finite useful lives are amortized over their estimated useful lives on a straight-line basis. We review these assets for potential impairment if/when facts or circumstances suggest that the carrying value of these assets may not be recoverable. (viii) Stock-Based Compensation Stock-based compensation expense for equity awards granted to our employees and members of our board of directors is recognized on a straight-line basis over each award's vesting period. Recognized compensation expense is net of an estimated forfeiture rate, representing the percentage of awards that are expected to be forfeited (by termination of employment or service) prior to vesting. We use the Black-Scholes option pricing model to determine the fair value of stock options (as of the date of grant) which carry service conditions for vesting. When applicable, we use the Monte Carlo valuation model to value equity awards (as of the date of grant) which carry combined market conditions and service conditions for vesting. The calculation of the fair value of stock options on the date of grant, and the recognition of stock-based compensation expense over the appropriate time period, requires uncertain assumptions, including (a) the pre-vesting forfeiture rate of the stock option, (b) the term of the stock option, (c) the stock price volatility over the term of the stock option, and (d) the risk-free interest rate over the term of the stock option. We estimate forfeiture rates based on our employees’ overall forfeiture history, which we believe will be representative of future results. We estimate the expected term of stock options granted based on our employees’ historical exercise patterns, which we believe will be representative of their future behavior. We estimate the volatility of our common stock on the date of grant based on historical volatility of our common stock for a look-back period that corresponds with the expected term. We estimate the risk-free interest rate based upon the U.S. Treasury yields in effect at award grant, for a period equaling the stock options’ expected term. (ix) Foreign Currency Translation We translate the assets and liabilities of our foreign subsidiaries that are stated in their functional currencies (i.e., local operating currencies), to U.S. dollars at the rates of exchange in effect at the reported balance sheet date. Revenues and expenses are translated using the monthly average exchange rates during the reported period. Unrealized gains and losses from the translation of our subsidiaries’ financial statements (that are initially denominated in the corresponding functional currency) are included as a separate component of “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. We record foreign currency transactions, when initially denominated in a currency other than the respective functional currency of our subsidiary, at the prevailing exchange rate on the date of the transaction. Resulting unrealized foreign exchange gains and losses from transactions with third parties are included in “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. All unrealized foreign exchange gains and losses associated with our intercompany loans are included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets, as these loans with our foreign subsidiaries are not expected to be settled in the "foreseeable future." For the period January 1, 2015 through March 31, 2015, unrealized foreign exchange gains and losses associated with our intercompany loans were included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets and in "other income (expense), net" in the Condensed Consolidated Statements of Operations. In periods prior to January 1, 2015, all unrealized foreign exchange gains and losses associated with intercompany loans were included in “other income (expense), net” in the Condensed Consolidated Statements of Operations. (x) Basic and Diluted Net (Loss) Income per Share We calculate basic and diluted net (loss) income per share using the weighted average number of common shares outstanding during the periods presented. In periods of a net loss, basic and diluted loss per share are the same. For the diluted earnings per share calculation, we adjust the weighted average number of common shares outstanding to include only dilutive stock options, warrants, and other common stock equivalents outstanding during the period. (xi) Income Taxes Deferred tax assets and liabilities are recorded based on the estimated future tax effects of temporary differences between the tax basis of assets and liabilities and amounts reported in the financial statements, as well as operating losses and tax credit carry forwards using enacted tax rates and laws that are expected to be in effect when the differences are expected to reverse. Realization of deferred tax assets is dependent upon future earnings, the timing and amount of which are uncertain. We have recorded a valuation allowance to reduce our deferred tax assets, because we believe that, based upon a weighting of positive and negative factors, it is more likely than not that these deferred tax assets will not be realized. If/when we determine that our deferred tax assets are realizable, an adjustment to the corresponding valuation allowance would increase our net income in the period that such determination was made. In the event that we are assessed interest and/or penalties from taxing authorities that have not been previously accrued, such amounts would be included in “benefit (provision) for income taxes” within the Condensed Consolidated Statements of Operations in the period the notice was received. (xii) Research and Development Costs Our research and development costs are expensed as incurred, or as certain milestone payments become due, generally triggered by clinical or regulatory events. (xiii) Fair Value Measurements We determine measurement-date fair value based on the proceeds that would be received through the sale of the asset, or that we would pay to settle or transfer the liability, in an orderly transaction between market participants. We utilize valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible. Fair value measurements are based on a three-tier hierarchy that prioritizes the inputs used in descending order to measure fair value. These tiers include the following: Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that are publicly accessible at the measurement date. Level 2: Observable prices that are based on inputs not quoted on active markets, but that are corroborated by market data. These inputs may include quoted prices for similar assets or liabilities or quoted market prices in markets that are not active to the general public. Level 3: Unobservable inputs are used when little or no market data is available.

Balance Sheet Account Detail

Balance Sheet Account Detail	3 Months Ended
	Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Balance Sheet Account Detail	BALANCE SHEET ACCOUNT DETAIL The composition of selected financial statement captions that comprise the accompanying Condensed Consolidated Balance Sheets are summarized below: (a) Cash and Cash Equivalents and Marketable Securities As of March 31, 2016 and December 31, 2015 , our holdings included within “cash and cash equivalents” and “marketable securities” were at major financial institutions. Our investment policy requires that investments in marketable securities be in only highly-rated instruments, which are primarily U.S. treasury bills or U.S. treasury-backed securities, and limited investments in securities of any single issuer. We maintain cash balances in excess of federally insured limits with reputable financial institutions. To a limited degree, the Federal Deposit Insurance Corporation ("FDIC") and other third parties insure these investments. However, these investments are not insured against the possibility of a complete loss of earnings or principal and are inherently subject to the credit risk related to the continued credit worthiness of the underlying issuer and general credit market risks. We manage such risks on our portfolio by investing in highly liquid, highly rated instruments, and limit investing in long-term maturity instruments. The carrying amount of our equity securities, money market funds, bank certificate of deposits ("Bank CDs"), and mutual funds approximates their fair value (utilizing Level 1 or Level 2 inputs – see Note 2(xiii) ) because of our ability to immediately convert these instruments into cash with minimal expected change in value. The following is a summary of our “cash and cash equivalents” and “marketable securities”: Marketable Securities Cost Gross Gross Estimated Cash and Cash Current Long March 31, 2016 Bank deposits $ 52,160 $ — $ — $ 52,160 $ 52,160 $ — $ — Money market funds 80,146 — — 80,146 80,146 — — Bank certificates of deposits 246 — — 246 — 246 — Mutual funds — — — — — — — Total cash and equivalents and marketable securities $ 132,552 $ — $ — $ 132,552 $ 132,306 $ 246 $ — December 31, 2015 Bank deposits $ 59,625 $ — $ — $ 59,625 $ 59,625 $ — $ — Money market funds 80,116 — — 80,116 80,116 — — Bank certificates of deposits 245 — — 245 — 245 — Mutual funds — — — — — — — Total cash and equivalents and marketable securities $ 139,986 $ — $ — $ 139,986 $ 139,741 $ 245 $ — As of March 31, 2016 , none of these securities had been in a continuous unrealized loss position longer than one year. (b) Property and Equipment, Net of Accumulated Depreciation “Property and equipment, net of accumulated depreciation” consist of the following: March 31, 2016 December 31, 2015 Computer hardware and software $ 3,824 $ 3,785 Laboratory equipment 622 608 Office furniture 355 355 Leasehold improvements 2,880 2,872 Property and equipment, at cost 7,681 7,620 (Less): Accumulated depreciation (6,871 ) (6,702 ) Property and equipment, net of accumulated depreciation $ 810 $ 918 Depreciation expense (included within “total operating costs and expenses” in the accompanying Condensed Consolidated Statements of Operations) for the three months ended March 31, 2016 and 2015 , was $0.2 million and $0.2 million , respectively. (c) Inventories “Inventories” consist of the following: March 31, 2016 December 31, 2015 Raw materials $ 1,782 $ 1,606 Work-in-process* 7,457 4,228 Finished goods 839 1,498 (Less:) Non-current portion of inventories included within "other assets" ** (6,923 ) (3,156 ) Inventories $ 3,155 $ 4,176 * In January 2016, we received $3.4 million of ZEVALIN antibody materials for its future manufacture (representing strategic long-term supply). ** The "non-current" portion of inventories is presented within "other assets" in the accompanying Condensed Consolidated Balance Sheet at March 31, 2016 . This value of $6.9 million represents product that we expect to sell beyond March 31, 2017. (d) Prepaid expenses and other assets “Prepaid expenses and other assets” consist of the following: March 31, 2016 December 31, 2015 Prepaid operating expenses $ 2,352 $ 3,507 Current portion of debt issuance costs* — — Prepaid expenses and other assets $ 2,352 $ 3,507 * Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith the FASB-issued Accounting Standards Update 2015-03, Simplifying the Presentation of Debt Issuance Costs (“ASU 2015-03”). These amounts were $2.0 million and $2.2 million (including current and non-current portions) as of March 31, 2016 and December 31, 2015, respectively. (e) Other receivables “Other receivables” consist of the following: March 31, 2016 December 31, 2015 Income tax receivable $ 754 $ 1,301 Insurance receivable 7,188 7,100 Mundipharma promissory note 2,347 2,215 CASI note - short term* 1,500 — Eagle service revenue and support costs 1,450 — Research and development expenses - reimbursements due 1,617 1,699 Other miscellaneous receivables 319 257 Other receivables $ 15,175 $ 12,572 * This full balance was prospectively reclassified as of March 31, 2016 to "other receivables" (presented within current assets on the accompanying Condensed Consolidated Balance Sheets) from "other assets" (presented within non-current assets) due to this note's maturity date of March 17, 2017 (i.e., within 12 months of March 31, 2016) - see Note 10 . (f) Intangible Assets and Goodwill “Intangible assets, net of accumulated amortization and impairment charges” consist of the following: March 31, 2016 Historical Accumulated Foreign Impairment Net Amount Full Remaining MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 n/a n/a EVOMELA distribution rights (1) 7,700 — — — 7,700 156 156 BELEODAQ distribution rights 25,000 (3,281 ) — — 21,719 160 139 MARQIBO distribution rights 26,900 (9,624 ) — — 17,276 81 48 FOLOTYN distribution rights 118,400 (31,834 ) — — 86,566 152 110 ZEVALIN distribution rights – U.S. 41,900 (31,477 ) — — 10,423 123 36 ZEVALIN distribution rights – Ex-U.S. 23,490 (13,543 ) (3,566 ) — 6,381 96 48 FUSILEV distribution rights (2) 16,778 (9,618 ) — (7,160 ) — 56 0 FOLOTYN out-license (3) 27,900 (9,789 ) — (1,023 ) 17,088 110 76 Total intangible assets $ 305,668 $ (109,166 ) $ (3,566 ) $ (8,183 ) $ 184,753 (1) The FDA approval of EVOMELA in March 2016 triggered a $6 million payment due to CyDex Pharmaceuticals, Inc. (a wholly-owned subsidiary of Ligand Pharmaceuticals Incorporated). This event also resulted in a reclassification of our $7.7 million "EVOMELA IPR&D" to "EVOMELA distribution rights" due to our ability to begin its commercialization with this FDA approval. In accordance with our capitalization policy for intangible assets, amortization will commence on the first day of the following month of this reclassification (i.e., April 1, 2016). (2) On February 20, 2015, the U.S. District Court for the District of Nevada found the patent covering FUSILEV to be invalid, which was upheld on appeal. On April 24, 2015, Sandoz began to commercialize a generic version of FUSILEV. This represented a “triggering event” under applicable GAAP in evaluating the value of our FUSILEV distribution rights as of March 31, 2015, resulting in a $7.2 million impairment charge (non-cash) in the first quarter of 2015. We accelerated amortization expense recognition in 2015 for the remaining net book value of FUSILEV distribution rights. (3) On May 29, 2013, we amended our FOLOTYN collaboration agreement with Mundipharma. As a result of the amendment, Europe and Turkey were excluded from Mundipharma’s commercialization territory, and their royalty rates and milestone payments to us were modified. This constituted a change under which we originally valued the FOLOTYN out-license as part of business combination accounting, resulting in an impairment charge (non-cash) of $1.0 million in the second quarter of 2013. December 31, 2015 Historical Accumulated Foreign Impairment Net Amount MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 EVOMELA IPR&D 7,700 — — — 7,700 BELEODAQ distribution rights 25,000 (2,812 ) — — 22,188 MARQIBO distribution rights 26,900 (8,544 ) — — 18,356 FOLOTYN distribution rights 118,400 (29,474 ) — — 88,926 ZEVALIN distribution rights – U.S. 41,900 (30,608 ) — — 11,292 ZEVALIN distribution rights – Ex-U.S. 23,490 (12,632 ) (4,353 ) — 6,505 FUSILEV distribution rights 16,778 (9,618 ) — (7,160 ) — FOLOTYN out-license 27,900 (9,109 ) — (1,023 ) 17,768 Total intangible assets $ 305,668 $ (102,797 ) $ (4,353 ) $ (8,183 ) $ 190,335 Intangible asset amortization expense recognized during the three months ended March 31, 2016 was $5.8 million , as compared to $14.0 million of amortization and impairment expense recognized in the prior year period (of which $7.2 million relates to the impairment of the FUSILEV distribution rights, and the remaining $6.9 million relates to scheduled amortization expense). Estimated intangible asset amortization expense for the remainder of 2016 and the five succeeding fiscal years and thereafter is as follows: Years Ending December 31, Remainder of 2016 $ 18,017 2017 24,023 2018 24,023 2019 21,417 2020 16,113 2021 14,634 2022 and thereafter 48,926 $ 167,153 “Goodwill” is comprised of the following: March 31, 2016 December 31, 2015 Acquisition of Talon (MARQIBO rights) $ 10,526 $ 10,526 Acquisition of ZEVALIN Ex-U.S. distribution rights 2,525 2,525 Acquisition of Allos (FOLOTYN rights) 5,346 5,346 Foreign currency exchange translation effects (353 ) (437 ) Goodwill $ 18,044 $ 17,960 (g) Other assets “Other assets” are comprised of the following: March 31, 2016 December 31, 2015 Equity securities and secured promissory note - CASI (see Note 10)* $ 7,520 $ 6,689 Supplies and deposits** 1,165 185 2018 Convertible Notes issuance costs (excluding current portion)*** — — Executive officer life insurance – cash surrender value 9,651 9,181 Inventories - non-current portion 6,923 3,156 Other miscellaneous assets 45 — Other assets $ 25,304 $ 19,211 * These equity securities were excluded from “marketable securities” (see Note 3(a) ) due to our intent to hold these securities for at least one year beyond March 31, 2016 , as discussed in Note 10 . Unrealized gains from these equity securities were recognized through “unrealized gain on available-for-sale securities" within the Condensed Consolidated Statements of Comprehensive Loss, and were $1.4 million for the three months ended March 31, 2016 . ** Of this balance at March 31, 2016, $1.0 million relates to ZEVALIN inventories that we intend to consume in research and development activities in future periods as part of our new contract manufacturer validation process. Accordingly, we have presented this value within "other assets" rather than "inventories" due to our present intention for these units. *** Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith ASU 2015-03. These amounts were $2.0 million and $2.2 million (including current and non-current portions) as of March 31, 2016 and December 31, 2015, respectively. (h) Accounts payable and other accrued liabilities “Accounts payable and other accrued liabilities” are comprised of the following : March 31, 2016 December 31, 2015 Trade accounts payable and other accrued liabilities $ 31,922 $ 26,684 Accrued rebates 6,978 18,166 Accrued product royalty 4,076 4,908 Allowance for returns 1,429 1,394 Accrued data and distribution fees 1,126 1,830 Accrued GPO administrative fees 521 1,058 Accrued inventory management fee 210 498 Allowance for chargebacks 1,241 2,001 Accounts payable and other accrued liabilities $ 47,503 $ 56,539 Amounts presented within “accounts payable and other accrued liabilities” in the accompanying Condensed Consolidated Balance Sheets specifically for gross-to-net ("GTN") estimates (see Note 2(i) ) are as follows: Rebates and Data and Returns Balance as of December 31, 2014 $ 45,822 $ 8,284 $ 1,135 Add: provisions 75,498 15,928 1,486 (Less): credits or actual allowances (101,153 ) (20,826 ) (1,227 ) Balance as of December 31, 2015 20,167 3,386 1,394 Add: provisions 19,952 2,227 590 (Less): credits or actual allowances (31,900 ) (3,755 ) (555 ) Balance as of March 31, 2016 $ 8,219 $ 1,858 $ 1,429 (i) Deferred revenue Deferred revenue (current and non-current) is comprised of the following: March 31, 2016 December 31, 2015 Mundipharma deferred revenue (see Note 11 ) $ 2,472 $ — FUSILEV deferred revenue* — 6,083 Dr. Reddy's out-license (see Note 16(b)(iii) ) 436 430 Deferred revenue $ 2,908 $ 6,513 * In the third quarter 2015, we deferred revenue recognition related to certain FUSILEV product shipments that did not meet our revenue recognition criteria (see Note 2(i)(a )), aggregating $9.9 million . Specifically, this deferral resulted from our inability to concurrently estimate future rebate values (with requisite precision) offered to our customers in order to compete with generic products. During the fourth quarter of 2015, we recognized $3.8 million for these third quarter shipments, and $6.1 million remained deferred as of December 31, 2015 . In the first quarter 2016, this $6.1 million of deferred revenue was recognized in full. (j) Other long-term liabilities Other long-term liabilities are comprised of the following: March 31, 2016 December 31, 2015 Accrued executive deferred compensation $ 7,117 $ 6,458 Deferred rent (non-current portion) 235 248 Clinical study holdback costs, non-current 19 — Other tax liabilities 738 738 Other long-term liabilities $ 8,109 $ 7,444

Gross-to-Net Product Sales

Gross-to-Net Product Sales	3 Months Ended
	Mar. 31, 2016
Revenue, Net [Abstract]
Gross-to-Net Product Sales	GROSS-TO-NET PRODUCT SALES The below table presents a GTN product sales reconciliation for the accompanying Condensed Consolidated Statement of Operations: Three Months Ended 2016 2015 Gross product sales $ 58,011 $ 62,598 Commercial rebates and government chargebacks (19,953 ) (18,144 ) Data and distribution fees, GPO fees, and inventory management fees (2,227 ) (5,571 ) Product returns allowance (590 ) (470 ) Net product sales $ 35,241 $ 38,413

Net Product Sales by Geographic

Net Product Sales by Geographic Region and Product Line	3 Months Ended
	Mar. 31, 2016
Segment Reporting [Abstract]
Net Product Sales by Geographic Region and Product Line	NET PRODUCT SALES BY GEOGRAPHIC REGION AND PRODUCT LINE The below table presents our net product sales by geography for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 United States $ 33,779 95.9 % $ 36,546 95.1 % International: Europe 1,462 4.1 % 644 1.7 % Asia Pacific* — — % 1,223 3.2 % Total international 1,462 4.1 % 1,867 4.9 % Net product sales $ 35,241 100.0 % $ 38,413 100.0 % * See Note 11 for discussion of our November 2015 out-license for Asia Pacific territory to Mundipharma. The below table presents our net product sales by product line for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 FUSILEV $ 15,209 43.2 % $ 20,167 52.5 % FOLOTYN 13,292 37.7 % 9,316 24.3 % ZEVALIN 2,783 7.9 % 4,223 11.0 % MARQIBO 929 2.6 % 1,893 4.9 % BELEODAQ 3,028 8.6 % 2,814 7.3 % Net product sales $ 35,241 100.0 % $ 38,413 100.0 %

Stock-Based Compensation

Stock-Based Compensation	3 Months Ended
	Mar. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Stock-Based Compensation	STOCK-BASED COMPENSATION We classify our stock-based compensation expense (inclusive of our incentive stock plan, employee stock purchase plan, and 401(k) contribution matching program) in the accompanying Condensed Consolidated Statements of Operations, based on the department to which the recipient belongs. Stock-based compensation expense included within “Total operating costs and expenses” for the three months ended March 31, 2016 and 2015 was as follows: Three Months Ended 2016 2015 Cost of product sales $ 27 $ — Research and development 381 433 Selling, general and administrative 2,769 2,029 Total stock-based compensation $ 3,177 $ 2,462

Net Loss Per Share

Net Loss Per Share	3 Months Ended
	Mar. 31, 2016
Earnings Per Share [Abstract]
Net Loss Per Share	NET LOSS PER SHARE Net loss per share was computed by dividing net loss by the weighted average number of common shares outstanding for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 Net loss $ (9,321 ) $ (25,562 ) Weighted average shares – basic and diluted 65,597,261 64,880,677 Net loss per share – basic and diluted $ (0.14 ) $ (0.39 ) The below outstanding securities were excluded from the above calculation of net loss per share because their impact would have been anti-dilutive due to net loss per share in the three months ended March 31, 2016 and 2015 , as summarized below: Three Months Ended 2016 2015 2018 Convertible Notes 11,401,284 11,401,284 Common stock options 982,748 1,825,868 Restricted stock awards 2,592,614 1,528,815 Common stock warrants — 71,227 Preferred stock 40,000 40,000 Total 15,016,646 14,867,194

Fair Value Measurements

Fair Value Measurements	3 Months Ended
	Mar. 31, 2016
Fair Value Disclosures [Abstract]
Fair Value Measurements	FAIR VALUE MEASUREMENTS The table below summarizes certain asset and liability fair values that are included within our accompanying Condensed Consolidated Balance Sheets, and their designations among three fair value measurement categories: March 31, 2016 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 246 $ — $ 246 Money market currency funds — 80,146 — 80,146 Equity securities 7,520 — — 7,520 Secured promissory note — — — — Mutual funds — 45 — 45 Deferred compensation investments, including life insurance cash surrender value — 9,651 — 9,651 $ 7,520 $ 90,088 $ — $ 97,608 Liabilities: Deferred executive compensation liability $ — $ 7,117 $ — $ 7,117 Deferred drug development liability — — 14,510 14,510 Ligand Contingent Consideration — — 6,000 6,000 Talon CVR — — 1,646 1,646 Corixa Liability — — 62 62 $ — $ 7,117 $ 22,218 $ 29,335 December 31, 2015 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 245 $ — $ 245 Money market currency funds — 80,116 — 80,116 Equity securities 5,189 — — 5,189 Deferred compensation investments, including life insurance cash surrender value — 9,181 — 9,181 $ 5,189 $ 89,542 $ — $ 94,731 Liabilities: Deferred executive compensation liability $ — $ 6,458 $ — $ 6,458 Deferred drug development costs — — 14,686 14,686 Ligand Contingent Consideration — — 5,227 5,227 Talon CVR — — 1,377 1,377 Corixa Liability — — 62 62 $ — $ 6,458 $ 21,352 $ 27,810 We did not have any transfers between Levels 1 and 2 for all periods presented. The following presents a roll forward of our liabilities for which we utilize Level 3 inputs in determining period-end value. These liabilities are included on our Condensed Consolidated Balance Sheets within “acquisition-related contingent obligations” and “drug development liability”. The basis of the various Level 3 valuation inputs are discussed in the Notes to these accompanying Condensed Consolidated Financial Statements. Our carrying amounts of financial instruments such as cash equivalents, accounts receivable, prepaid expenses, accounts payable, and accrued liabilities, excluding acquisition-related contingent obligations, approximate their related fair values due to their short-term nature. Fair Value Measurements of Balance at December 31, 2014 $ 23,127 Deferred drug development costs (1,099 ) Ligand Contingent Consideration 326 Talon CVR (1,002 ) Corixa Liability — Balance at December 31, 2015 21,352 Deferred drug development costs (see Note 15 ) (176 ) Ligand Contingent Consideration (see Note 9(b)) 773 Talon CVR (see Note 9(a)) 269 Corixa Liability (see Note 16(b)(i) ) — Balance at March 31, 2016* $ 22,218 * This amount is comprised of the current and non-current portions of “drug development liability” and “acquisition-related contingent obligations” on our accompanying Condensed Consolidated Balance Sheets.

Business Combinations and Conti

Business Combinations and Contingent Consideration	3 Months Ended
	Mar. 31, 2016
Business Combinations [Abstract]
Business Combinations and Contingent Consideration	BUSINESS COMBINATIONS AND CONTINGENT CONSIDERATION (a) Acquisition of Talon Therapeutics, Inc. and Related Contingent Consideration Overview of Talon Acquisition On July 17, 2013 , we purchased all of the outstanding shares of common stock of Talon Therapeutics, Inc. (“Talon”). Through the acquisition of Talon, we gained worldwide rights to MARQIBO. The Talon purchase consideration comprised of (i) an aggregate upfront cash amount of $11.3 million , (ii) issuance of 3.0 million shares of our common stock, then equivalent to $26.3 million (based on a closing price of $8.77 per share on July 17, 2013), and (iii) the issuance of contingent value rights (“CVR”) initially valued at $6.5 million . The CVR was valued using a valuation model that probability-weights expected outcomes (ranging from 50% to 100% ) and discounts those amounts to their present value, using an appropriate discount rate (these represent unobservable inputs and are therefore classified as Level 3 inputs – see Note 2 (xiii) ). The CVR has a maximum payout of $195 million if all sales and regulatory approval milestones are achieved, as summarized below: • $5 million upon the achievement of net sales of MARQIBO in excess of $30 million in any calendar year • $10 million upon the achievement of net sales of MARQIBO in excess of $60 million in any calendar year • $25 million upon the achievement of net sales of MARQIBO in excess of $100 million in any calendar year • $50 million upon the achievement of net sales of MARQIBO in excess of $200 million in any calendar year • $100 million upon the achievement of net sales of MARQIBO in excess of $400 million in any calendar year • $5 million upon receipt of marketing authorization from the FDA regarding Menadione Topical Lotion Talon CVR Fair Value as of March 31, 2016 and December 31, 2015 The CVR fair value will continue to be evaluated on a quarterly basis. Current and future changes in its fair value results from the likelihood and timing of milestone achievement and/or the corresponding discount rate applied thereon. Adjustments to CVR fair value are recognized within “change in fair value of contingent consideration related to acquisitions” in the accompanying Condensed Consolidated Statements of Operations. Fair Value December 31, 2015 $ 1,377 Fair value adjustment for the three months ended March 31, 2016 269 March 31, 2016 $ 1,646 (b) Acquisition of Rights to EVOMELA and Related Contingent Consideration Overview of Acquisition of Rights to EVOMELA In March 2013, we completed the acquisition of exclusive global development and commercialization rights to Captisol-enabled®, propylene glycol-free MELPHALAN (which we recently branded as “EVOMELA”) for use as a conditioning treatment prior to autologous stem cell transplant for patients with MM. We acquired these rights from CyDex Pharmaceuticals, Inc. a wholly-owned subsidiary of Ligand Pharmaceuticals Incorporated (“Ligand”) for an initial license fee of $3 million . We accounted for this transaction as a business combination, which requires that assets acquired and liabilities assumed be recognized on the balance sheet at their fair values as of the transaction date. We are required to pay Ligand additional amounts up to an aggregate $66 million (inclusive of the $6 million milestone payment triggered in March 2016, as further discussed below), upon the achievement of certain regulatory milestones and net sales thresholds, and we also assumed full financial responsibility for its ongoing clinical and regulatory development program. We also must pay royalties of 20% on our future net sales of EVOMELA in all territories. Consideration Transferred The acquisition-date fair value of the consideration transferred consisted of the following: Cash consideration $ 3,000 Ligand Contingent Consideration 4,700 Total purchase consideration $ 7,700 Fair Value Estimate of Asset Acquired and Liability Assumed The total purchase consideration is allocated to the acquisition of the net tangible and intangible assets based on their estimated fair values as of the closing date. The allocation of the total purchase price to the net assets acquired is as follows: EVOMELA IPR&D $ 7,700 We estimated the fair value of the in-process research and development using the income approach. The income approach uses valuation techniques to convert future amounts to a single present amount (discounted). Our measurement is based on the value indicated by current market expectations about those future amounts. The fair value estimate took into account our estimates of future incremental earnings that may be achieved upon regulatory approval, promotion, and distribution associated with the rights, and included estimated cash flows of approximately 10 years and a discount rate of approximately 25% . The fair value of the contingent consideration liability assumed was determined using the probability of success and the discounted cash flow method of the income approach (representing unobservable inputs and are therefore represent Level 3 values - see Note 2(xiii) ). In March 2016, the FDA approved EVOMELA, triggering a $6 million milestone payment to Ligand (“Ligand Contingent Consideration”) that was paid in April 2016. "EVOMELA IPR&D" of $7.7 million was reclassified to "EVOMELA distribution rights" within "Intangible assets, net of accumulated amortization and impairment charges" in the accompanying Condensed Consolidated Balance Sheets as of March 31, 2016. Amortization related to this intangible asset will commence on April 1, 2016. Ligand Contingent Consideration Fair Value as of March 31, 2016 and December 31, 2015 The fair value of the Ligand Contingent Consideration was the full $6 million payment due as of March 31, 2016 . Accordingly, in the first quarter of 2016, we recorded a $0.8 million adjustment to the “change in fair value of contingent consideration related to acquisitions” in the accompanying Condensed Consolidated Statements of Operations. Fair Value of December 31, 2015 $ 5,227 Fair value adjustment for the three months ended March 31, 2016 773 March 31, 2016 $ 6,000 (c) Allos Acquisition We acquired Allos Therapeutics, Inc. (“Allos”) on September 5, 2012, which was accounted for as a business combination. Our total cash consideration for this acquisition was $205.2 million , through which we acquired FOLOTYN distribution rights. We have no contingent consideration obligations as part of this transaction.

Out-License of Marqibo, Zevalin

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	3 Months Ended
	Mar. 31, 2016
Other Commitments [Abstract]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016, we acquired an additional 1.7 million common shares of CASI at par value, resulting in our total holding of 7.1 million common shares as of March 31, 2016. CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $7.5 million as of March 31, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of March 31, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.

Out-License Of Zevalin In Certa

Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	3 Months Ended
	Mar. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016, we acquired an additional 1.7 million common shares of CASI at par value, resulting in our total holding of 7.1 million common shares as of March 31, 2016. CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $7.5 million as of March 31, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of March 31, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma	OUT-LICENSE OF ZEVALIN IN CERTAIN EX-U.S. TERRITORIES TO MUNDIPHARMA On November 16, 2015, we entered into an out-license agreement with Mundipharma International Corporation Limited for their commercialization of ZEVALIN in Asia (excluding India and Greater China), Australia, New Zealand, Africa, the Middle East, and Latin America (including the Caribbean). In return, we received $18 million (comprised of $15 million received in December 2015 and $3 million received in January 2016). Of these proceeds, $15 million was recognized within "license fees and service revenue" in the fourth quarter of 2015, and $0.4 million of the $3 million payment was recognized in the same caption in the first quarter of 2016. As of March 31, 2016 , $2.5 million remains deferred and is presented within "deferred revenue" (current and non-current) in the accompanying Condensed Consolidated Balance Sheets. As Mundipharma has sales of ZEVALIN kits in their territories, the remaining unrecognized portion of this $3 million payment will be reported by us within "license fees and service revenue" on an established per-unit basis. Mundipharma is required to reimburse us for our payment of royalties due to Bayer from their ZEVALIN sales - see Note 16(b)(ii) . We are also eligible to receive an additional $2 million upon Mundipharma's achievement of a specified sales milestone, that if/when achieved, will also be reported within "license fees and service revenue". In connection with this out-license, on November 16, 2015, we concurrently sold to Mundipharma K.K., all common stock of Spectrum Pharmaceuticals GK (the legal entity through which we previously sold ZEVALIN in Japan) for $2.2 million (in the form of an unsecured note, payable no later than May 2016), representing its net asset value (excluding inventory) as of November 16, 2015.

Out-License Of Zevalin, Folotyn

Out-License Of Zevalin, Folotyn, Beleodaq, And Marqibo In Canada Territory To Servier	3 Months Ended
	Mar. 31, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF MARQIBO, ZEVALIN, AND EVOMELA IN CHINA TERRITORY TO CASI Overview of CASI Out-License On September 17, 2014, we executed three product out-license agreements with a perpetual term (collectively, the “CASI Out-License”) with CASI Pharmaceuticals, Inc. (“CASI”), a publicly-traded biopharmaceutical company (NASDAQ: CASI) with a primary focus on the China market. Under the CASI Out-License, we granted CASI the exclusive rights to distribute two of our commercialized oncology drugs, ZEVALIN and MARQIBO, and our Phase 3 drug candidate, EVOMELA (“CASI Out-Licensed Products”) in greater China (which includes Taiwan, Hong Kong and Macau). In return, we received CASI equity for the rights related to ZEVALIN and EVOMELA and a secured promissory note for the rights related to MARQIBO. Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities. In February 2016, we acquired an additional 1.7 million common shares of CASI at par value, resulting in our total holding of 7.1 million common shares as of March 31, 2016. CASI will be responsible for the development and commercialization of these three drugs, including the submission of import drug registration applications to regulatory authorities and conducting any confirmatory clinical studies in greater China. We will provide CASI with future commercial supply of the CASI Out-Licensed Products under typical market terms. Proceeds Received in the Third Quarter of 2014 The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $7.5 million as of March 31, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of March 31, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets. In addition, CASI will be responsible for paying any royalties or milestones that we are obligated to pay to our third-party licensors resulting from the achievement of certain milestones and/or sales of CASI Out-Licensed Products, but only to the extent of the greater China portion of such royalties or milestones.
Servier Canada [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Out-License Of Zevalin, Folotyn, Beleodaq, and Marqibo In Canada Territory To Servier/Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI	OUT-LICENSE OF ZEVALIN, FOLOTYN, BELEODAQ, AND MARQIBO IN CANADA TERRITORY TO SERVIER On January 8, 2016, we entered into a strategic partnership with Servier Canada, Inc. for the out-licenses of ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO. We received $6 million in upfront payments in the first quarter of 2016 which was recognized within "license fees and service revenue" in the accompanying Condensed Consolidated Statement of Operations. We will also receive development milestone payments if/when achieved, and a high single-digit royalty on their sales of these products.

Co-Promotion Arrangement With E

Co-Promotion Arrangement With Eagle Pharmaceuticals	3 Months Ended
	Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Co-Promotion Arrangement With Eagle Pharmaceuticals	CO-PROMOTION ARRANGEMENT WITH EAGLE PHARMACEUTICALS On November 4, 2015, we executed an agreement with Eagle Pharmaceuticals, Inc. ("Eagle") whereby designated members of our sales force will concurrently market up to six of Eagle's pharmaceutical products along with our products, in return for fixed monthly payments over the initial 18 month contract term through June 30, 2017, aggregating $12.8 million (the "Eagle Agreement"). We are also eligible to receive milestone payments of up to $5 million for sales made in 2016 that exceed certain thresholds, and up to $4 million for sales made in the first half 2017 that exceed certain thresholds. In addition, for performance above such sales levels in 2016, and in the first half of 2017, we are eligible to receive variable-based payments in the high single-digits on incremental sales of Eagle's products above these established threshold levels. The fixed payments received by us, as well as reimbursable costs for certain marketing activities that we coordinate with third parties on Eagle's behalf, are recognized within "license fees and service revenue" on our accompanying Consolidated Statement of Operations. This amount was $1.9 million for the quarter ended March 31, 2016 . Any variable payments due to us will be recognized in the period earned and reported within the same revenue caption. An allocation of our sales personnel costs that are dedicated to Eagle sales activities are reported within "cost of service revenue" on our accompanying Consolidated Statement of Operations, as are reimbursable costs for Eagle marketing activities. These were an aggregate $1.3 million for the quarter ended March 31, 2016 . Eagle may extend the initial term of this agreement by six months to December 31, 2017 at its sole election. Any extensions after December 31, 2017 require mutual consent and will be for six months per extension. The Eagle Agreement may be terminated by either party for uncured material breaches and certain other events following a change of control or insolvency of either party, and solely by Eagle for convenience with 60 days written notice, subject to an established termination fee, as calculated within the Eagle Agreement.

Convertible Senior Notes

Convertible Senior Notes	3 Months Ended
	Mar. 31, 2016
Debt Disclosure [Abstract]
Convertible Senior Notes	CONVERTIBLE SENIOR NOTES Overview On December 17, 2013, we entered into an agreement for the sale of $120 million aggregate principal amount of 2.75% Convertible Senior Notes due December 2018 (the “2018 Convertible Notes”). The 2018 Convertible Notes are convertible into shares of our common stock at a conversion rate of 95 shares per $1,000 principal amount of the 2018 Convertible Notes, equating to 11.4 million common shares if fully converted. The in-the-money conversion price is equivalent to $10.53 per common share. The conversion rate and conversion price is subject to adjustment under certain limited circumstances. The 2018 Convertible Notes bear interest at a rate of 2.75% per year, payable semiannually in arrears on June 15 and December 15 of each year. The 2018 Convertible Notes will mature and become payable on December 15, 2018, subject to earlier conversion into common stock at the holders’ option. The sale of the 2018 Convertible Notes closed on December 23, 2013 and our net proceeds were $115.4 million , after deducting banker and professional fees of $4.6 million . We used a portion of these net proceeds to simultaneously enter into “bought call” and “sold warrant” transactions with Royal Bank of Canada (collectively, the “Note Hedge”). We recorded the Note Hedge on a net cost basis of $13.1 million , as a reduction to “additional paid-in capital” in our accompanying Condensed Consolidated Balance Sheets. Under applicable GAAP, the Note Hedge transaction is not expected to be marked-to-market through earnings or comprehensive income in future reported periods. Conversion Hedge We entered into Note Hedge transactions to reduce the potential dilution to our stockholders and/or offset any cash payments that we are required to make in excess of the principal amount, upon conversion of the 2018 Convertible Notes (in the event that the market price of our common stock is greater than the conversion price). The strike price of the “bought call” is equal to the conversion price and conversion rate of the 2018 Convertible Notes, matching the 11.4 million common shares the 2018 Convertible Notes may be converted into. The strike price of our “sold warrant” is $14.03 per share of our common stock, and is also for 11.4 million common shares. Conversion Events On and after June 15, 2018, and until the close of business on the second scheduled trading day immediately preceding the maturity date, holders may convert all or a portion of their 2018 Convertible Notes. Prior to June 15, 2018, holders may convert all or a portion of their 2018 Convertible Notes only under any of the following circumstances: (1) during any fiscal quarter (and only during such fiscal quarter), if, for at least 20 trading days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than or equal to 130% of the Notes' conversion price on such trading day; (2) during the five consecutive business day period immediately following any five consecutive trading day period in which, for each trading day of that measurement period, the trading price per $1,000 principal amount of 2018 Convertible Notes for such trading day was less than 98% of the product of (i) the last reported sale price of our common stock on such trading day and (ii) the Notes' conversion rate on such trading day; (3) upon the occurrence of certain corporate transactions; and (4) at any time prior to our stockholders’ approval to settle the 2018 Convertible Notes in our common shares and/or cash. As of March 31, 2016 , the 2018 Convertible Notes are not eligible to be converted into our common stock, as none of the above elements (1) through (4) were met. Our stockholders’ approval of "flexible settlement" occurred at our Annual Meeting of Stockholders on June 29, 2015. As a result, we may (at our election) settle any future conversions of the 2018 Convertible Notes by paying or delivering cash, shares of our common stock, or a combination of cash and shares of our common stock. However, if the holders of the Convertible Notes do not elect any conversion into our common stock, our December 2018 obligation to repay the principal amount of $120 million in cash, plus any accrued and unpaid interest, is unchanged. Carrying Value and Fair Value The carrying value of the 2018 Convertible Notes as of March 31, 2016 is summarized as follows: Principal amount $ 120,000 (Less): Unamortized debt discount (amortized through December 2018) (17,067 ) (Less): Debt issuance costs (see Note 3(d) ) (2,000 ) March 31, 2016 carrying value $ 100,933 As of March 31, 2016 and December 31, 2015 , the estimated aggregate fair value of the 2018 Notes is $106.6 million and $105.1 million , respectively. These fair value estimates are less than the principal amount of $120 million , largely since the conversion feature of the 2018 Notes was, and remains, out-of-the-money. These estimated fair values represent a Level 2 measurement (see Note 2(xiii) ), based upon the 2018 Convertible Notes' quoted bid price at each date in a thinly-traded market. Components of Interest Expense on 2018 Convertible Notes The following table sets forth the components of interest expense recognized in the accompanying Condensed Consolidated Statements of Operations for the 2018 Convertible Notes for the three months ended March 31, 2016 : Contractual coupon interest expense $ 825 Amortization of debt issuance costs 171 Accretion of debt discount 1,385 Total $ 2,381 Effective interest rate 8.66 %

Mundipharma Agreement And Drug

Mundipharma Agreement And Drug Development Liability	3 Months Ended
	Mar. 31, 2016
Business Combinations [Abstract]
Mundipharma Agreement And Drug Development Liability	MUNDIPHARMA AGREEMENT AND DRUG DEVELOPMENT LIABILITY As the result of our acquisition of Allos Therapeutics, Inc. on September 5, 2012 (through which we obtained distribution rights for FOLOTYN), we assumed its obligations under an active strategic collaboration agreement with a third-party, Mundipharma (the “Mundipharma Collaboration Agreement”). Under the Mundipharma Collaboration Agreement, we retained full commercialization rights for FOLOTYN in the U.S. and Canada, with Mundipharma having exclusive rights to commercialize FOLOTYN in all other countries in the world (the “Mundipharma Territories”). On May 29, 2013, the Mundipharma Collaboration Agreement was amended and restated (the “Amended Mundipharma Collaboration Agreement”), in order to modify: (i) the scope of the licensed territory, (ii) milestone payments, (iii) royalty rates, and (iv) drug development obligations. In connection with the Amended Mundipharma Collaboration Agreement, we received a one-time $7 million payment from Mundipharma for certain research and development activities to be performed by us. As a result of the Amended Mundipharma Collaboration Agreement, (a) Europe and Turkey were excluded from Mundipharma’s commercialization territory, (b) we may receive regulatory milestone payments of up to $16 million , and commercial progress and sales-dependent milestone payments of up to $107 million , (c) we will receive tiered double-digit royalties based on net sales of FOLOTYN within Mundipharma’s licensed territories, and (d) we and Mundipharma will bear our own FOLOTYN development costs. On May 29, 2015 and effective as of May 1, 2015, we entered into an amendment to the Amended Mundipharma Collaboration Agreement (the “Amendment”). Pursuant to the Amendment, among other things, the parties revised the conditions to our exercise of the option to gain commercialization rights in Switzerland from Mundipharma, and also revised tiered double digit royalties payable by Mundipharma on net sales in Switzerland. The fair value of this liability is included in the current and long-term portions of “drug development liability” within the accompanying Condensed Consolidated Balance Sheets, and it includes our assumptions about personnel needed to perform these research and development activities, third party costs for projected clinical trial enrollment, and patient treatment-related follow up through approximately 2031. The fair value of our “drug development liability” within our accompanying Condensed Consolidated Balance Sheets was estimated using the discounted income approach model. The unobservable inputs (i.e., Level 3 inputs - see Note 2(xiii) ) in this valuation model that have the most significant effect on these liabilities include (i) estimates of research and development personnel costs needed to perform the research and development services, (ii) estimates of expected cash outflows to third parties for services and supplies during the expected period of performance through 2031, and (iii) an appropriate discount rate for these expenditures. These inputs are reviewed by management on a quarterly basis for continued applicability. We assess this liability at each reporting date and record its adjustment through “research and development” expense in our accompanying Condensed Consolidated Statements of Operations. Drug Drug Total Drug Balance at December 31, 2015 $ 259 $ 14,427 $ 14,686 Transfer from long-term to current in 2016 74 (74 ) — (Less): Expenses incurred in 2016 (176 ) — (176 ) Balance at March 31, 2016 $ 157 $ 14,353 $ 14,510

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
	Mar. 31, 2016
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	COMMITMENTS AND CONTINGENCIES (a) Facility Leases We lease our principal executive office in Henderson, Nevada under a non-cancelable operating lease expiring April 30, 2019 . We also lease our research and development facility in Irvine, California under a non-cancelable operating lease expiring May 31, 2019 , in addition to several other administrative office leases. Each lease agreement contains scheduled rent increases which are accounted for on a straight-line basis. (b) In-Licensing and Out-Licensing Agreements, Co-Development Agreements, and Milestone Payments Our drug candidates are being developed pursuant to license agreements that provide us with territory-specific rights to its manufacture, sublicense, and sale. We are generally responsible for all development costs, patent filings and maintenance costs, sales and marketing costs, and liability insurance costs. We are also obligated to make certain milestone payments to third parties upon the achievement of regulatory and sales milestones that are specified in these license agreements. We estimate and present a corresponding liability on our Condensed Consolidated Balance Sheets when amounts are probable and reasonably estimable. In addition, we are obligated to pay royalties based on our current and future net sales of in-licensed products. Our most significant of these agreements are listed and summarized below: (i) ZEVALIN U.S.: In-Licensing and Development in the U.S. In December 2008, we acquired rights to commercialize and develop ZEVALIN in the U.S. as the result of a transaction with Cell Therapeutics, Inc. (“CTI”) through our wholly-owned subsidiary, RIT Oncology LLC (“RIT”). We assumed certain agreements with various third parties related to ZEVALIN intellectual property for its manufacture, use, and sale in the U.S. In accordance with the terms of assumed contracts, we are required to meet specified payment obligations, including a milestone payment to Corixa Corporation of $5 million based on ZEVALIN sales in the U.S. (the “Corixa Liability”). This milestone has not yet been met, and $0.1 million for this potential milestone achievement is included within “acquisition-related contingent obligations” in our accompanying Condensed Consolidated Balance Sheet as of March 31, 2016 and December 31, 2015 , respectively. Our U.S. net sales-based royalties are in the low to mid-single digits to Genentech, Inc. and mid-teens to Biogen. (ii) ZEVALIN Ex-U.S.: In-License and Asset Purchase Agreement with Bayer Pharma In April 2012, through our wholly-owned subsidiary, Spectrum Pharmaceuticals Cayman, L.P., we completed the acquisition of licensing rights to market ZEVALIN outside of the U.S. from Bayer Pharma AG (“Bayer”). ZEVALIN is currently approved in approximately 40 countries outside the U.S. for the treatment of B-cell non-Hodgkin lymphoma, including countries in Europe, Latin America, and Asia. In consideration for the rights granted under the agreement, concurrent with the closing, we paid Bayer a one-time fee of €19 million . Our ex-U.S. net sales-based royalty to Bayer ranges between the single digits to mid-teens. We amended the agreement in February 2016. Under the amendment, in the event that we elect to sublicense the rights in certain countries, our applicable royalty on net sales to Bayer would be adjusted to a tiered rate from the single digits to 20% in such countries. Unless earlier terminated, the term of the agreement, as amended, continues until the expiration of the last-to-expire patent covering the sale of a licensed product in the relevant country, or 15 years from the date of first commercial sale of the licensed product in such country, whichever is longer. (iii) ZEVALIN Ex-U.S.: Out-License Agreement with Dr. Reddy’s Effective June 27, 2014, we executed an exclusive License Agreement with Dr. Reddy’s Laboratories Ltd. (“Dr. Reddy’s”), for the distribution rights of ZEVALIN within India. The agreement term is 15 years from the receipt of pending approval of ZEVALIN from the Drug Controller General of India. On December 17, 2014, upon the execution of a supply agreement, an upfront and non-refundable payment of $0.5 million was triggered and was paid to us in February 2015. The recognition of this upfront payment is reported on a straight-line basis within “license fee and service revenue” on the Condensed Consolidated Statements of Operations over a 10 year term through December 2024. Additionally, sales and regulatory milestones (aggregating $3 million ) will become payable to us when achieved by Dr. Reddy’s, as well as a 20% royalty on net sales of ZEVALIN in India. (iv) ZEVALIN Ex-U.S.: Out-License Agreement with Mundipharma On November 16, 2015, we entered into an out-license agreement with Mundipharma International Corporation Limited ("Mundipharma") for their commercialization of ZEVALIN in Asia (excluding India and Greater China), Australia, New Zealand, Africa, the Middle East, and Latin America (including the Caribbean). In return, we received $18 million (comprised of $15 million received in December 2015 and $3 million received in January 2016). Of these proceeds, $15 million was recognized within "license fees and service revenue" in the fourth quarter of 2015, and $0.4 million of the $3 million payment was recognized in the same caption in the first quarter of 2016. As of March 31, 2016, $2.5 million remains deferred and is presented within "deferred revenue" (current and non-current) in the accompanying Condensed Consolidated Balance Sheets. As Mundipharma has sales of ZEVALIN kits in their territories, the remaining unrecognized portion of this $3 million value will be recognized by us in subsequent periods within "license fees and service revenue" on an established per-unit basis. Mundipharma is required to reimburse us for our payment of royalties due to Bayer from their ZEVALIN sales (see Note 16(b)(ii)). We are also eligible to receive an additional $2 million upon Mundipharma's achievement of a specified sales milestone, that if/when achieved, will also be reported within "license fees and service revenue". (v) FUSILEV: In-License Agreement with Merck & Cie AG In May 2006, we amended and restated a license agreement with Merck & Cie AG (“Merck”), which we assumed in connection with our March 2006 acquisition of the assets of Targent, Inc. Pursuant to the license agreement with Merck, we obtained the exclusive license to use regulatory filings related to FUSILEV and a non-exclusive license under certain patents and know-how to develop, manufacture, use, and sell FUSILEV in the field of oncology in North America in return for a royalty percentage (in the mid-single digits) of net sales. Merck is eligible to receive a $0.2 million payment from us upon the achievement of a FDA approval of an oral form of FUSILEV. This milestone has not yet been met, and no amounts have been accrued in our accompanying Condensed Consolidated Balance Sheets for its potential achievement. (vi) FOLOTYN: In-License Agreement with Sloan-Kettering Institute, SRI International and Southern Research Institute In December 2002, Allos entered into the FOLOTYN License Agreement with Sloan-Kettering Institute for Cancer Research, SRI International, and Southern Research Institute. As a result of Allos becoming our wholly owned subsidiary in September 2012, we are bound by the FOLOTYN License Agreement under which we obtained exclusive worldwide rights to a portfolio of patents and patent applications related to FOLOTYN and its uses. Under the terms of the FOLOTYN License Agreement, we are required to fund all development programs and will have sole responsibility for all commercialization activities. In addition, we pay graduated royalties to our licensors based on our (including sub licensees) worldwide annual net sales of FOLOTYN. Royalties are 8% of annual worldwide net sales up to $150 million ; 9% of annual worldwide net sales of $150 million through $300 million ; and 11% of annual worldwide net sales in excess of $300 million . (vii) EVOMELA: In-License Agreement with Cydex Pharmaceuticals, Inc. In March 2013, we completed the acquisition of exclusive global development and commercialization rights to EVOMELA from Ligand (see Note 9(b) ). We filed a New Drug Application ("NDA") with the FDA in December 2015 for its use as a conditioning treatment prior to autologous stem cell transplant for patients with MM. On March 10, 2016, the FDA communicated its approval of the NDA for EVOMELA. In connection with this FDA approval, we made a $6 million milestone payment to Ligand on April 13, 2016. We are required to pay Ligand additional amounts of up to $66 million (inclusive of the $6 million milestone payment we made for FDA approval), upon the achievement of certain regulatory milestones and net sales thresholds, which we have valued at $6 million and $5.2 million within “acquisition-related contingent obligations” in our accompanying Condensed Consolidated Statements of Operations as of March 31, 2016 and December 31, 2015 , respectively. We will also pay royalties of 20% on our net sales of licensed products in all territories. (viii) MARQIBO: Contingent Consideration Agreement with Talon Therapeutics, Inc. In July 2013, we completed the acquisition of Talon, through which we obtained exclusive global development and commercialization rights to MARQIBO (see Note 9(a) ). As part of this acquisition, we issued the former Talon stockholders contingent value rights (“CVR”) that we have valued and presented on our accompanying Condensed Consolidated Balance Sheets as a $1.6 million and $1.4 million liability within “acquisition-related contingent obligations” as of March 31, 2016 and December 31, 2015 , respectively. The CVR has a maximum payout value of $195 million if all sales and regulatory approval milestones are achieved. (ix) APAZIQUONE: License Agreements with Allergan, Inc. and NDDO Research Foundation In October 2008, we entered into an exclusive development and commercialization collaboration agreement with Allergan for APAZIQUONE. Pursuant to the terms of the agreement, Allergan paid us an up-front non-refundable fee of $41.5 million at closing (which we have amortized through revenue within “license fees and service revenue” in full as of December 31, 2013). In October 2008, pursuant to a letter agreement with NDDO Research Foundation (“NDDO”), we agreed to pay NDDO the following in relation to APAZIQUONE milestones: (a) upon FDA acceptance of the NDA, the issuance of 25,000 of our common shares (which occurred in March 2016, and the $0.1 million value of these shares is included in "research and development" expense for the three months ended March 31, 2016) and (b) upon FDA approval of the drug (its target decision date is set for December 11, 2016), a one-time payment of $0.3 million . In January 2013, we entered into a second amendment to the license, development, supply and distribution agreement with Allergan to amend the agreement and reacquire the rights originally licensed to Allergan in the U.S., Europe, and other territories in exchange for a tiered single-digit royalty on certain products containing APAZIQUONE, and relieved Allergan of its development and commercialization obligations. (x) APAZIQUONE: Collaboration Agreement with Nippon Kayaku Co. LTD. In November 2009, we entered into a collaboration agreement with Nippon Kayaku Co., LTD. (“Nippon Kayaku”) for the development and commercialization of APAZIQUONE in Asia, except North and South Korea (the “Nippon Kayaku Territory”). In addition, Nippon Kayaku received exclusive rights to APAZIQUONE for the treatment of non-muscle invasive bladder cancer in Asia (other than North and South Korea), including Japan and China. Nippon Kayaku will conduct APAZIQUONE clinical trials in the Nippon Kayaku Territory pursuant to a development plan. Further, Nippon Kayaku will be responsible for all expenses relating to the development and commercialization of APAZIQUONE in the Nippon Kayaku Territory. Under the terms of this agreement, Nippon Kayaku paid us an upfront fee of $15 million (which we have amortized through revenue within “license fees and service revenue” in full as of December 31, 2013). Nippon Kayaku is also obligated to make additional payments to us based on the achievement of certain development, regulatory and commercialization milestones. Under the terms of the agreement, we are entitled to payment of $10 million and $126 million upon achievement of certain regulatory and commercialization milestones, respectively. Also, Nippon Kayaku has agreed to pay us royalties based on a percentage of net sales of the subject products in the defined territory in the mid-teen digits. (xi) BELEODAQ: In-License and Collaboration Agreement with Onxeo In February 2010, we entered into a licensing and collaboration agreement with TopoTarget A/S (now Onxeo DK) (“Onxeo”), as amended in October 2013, for the development and commercialization of BELEODAQ. The agreement provides that we have the exclusive right to manufacture, develop, and commercialize BELEODAQ in North America and India, with an option for China. Pursuant to the terms of this agreement, we paid Onxeo an upfront fee of $30 million in 2010. Under continuing terms, all development, including studies, will be conducted under a joint development plan, which we will fund 70% of such costs, and Onxeo will fund 30% . We have final decision-making authority for all developmental activities in North America and India (and China upon exercise of its option). Onxeo has final decision-making authority for all developmental activities in all other jurisdictions. In February 2014, upon FDA acceptance of our new drug application, we issued one million shares of our common stock, and made a $10 million milestone payment to Onxeo. The aggregate payout value of this first milestone at achievement was $17.8 million , and was recognized within “research and development” in the first quarter of 2014. In July 2014, we received approval from the FDA for BELEODAQ’s use for injection and treatment of relapsed or refractory peripheral T-cell lymphoma. As a result, we paid a second milestone payment to Onxeo of $25 million in November 2014, which we capitalized as an amortizable intangible asset. Other potential milestone payments due upon BELEODAQ regulatory achievements and sales thresholds (aggregating up to $278 million ) are not included within “total liabilities” in our accompanying Condensed Consolidated Balance Sheets. We will pay Onxeo future royalties in the mid-teen digits based on net sales of BELEODAQ. The agreement will continue until the expiration of the last royalty payment period in the last country in the defined territory with certain provisions surviving, unless earlier terminated in accordance with its terms. (xii) SPI-2012: Co-Development and Commercialization Agreement with Hanmi Pharmaceutical Company In January 2012 (and as amended in March 2014 and October 2014), we entered into a License, Development, and Supply Agreement with Hanmi Pharmaceutical Company, Ltd. (“Hanmi”), for SPI-2012, formerly known as “LAPS-GCSF”, a drug based on Hanmi’s proprietary LAPSCOVERY™ technology for the treatment of chemotherapy induced neutropenia. Under the terms of the agreement, as amended, we have primary financial responsibility for the SPI-2012 development plan. We have worldwide rights for SPI-2012, except for Korea, China, and Japan. As of March 31, 2016, we owed Hanmi a milestone payment of $1.9 million (as quantified under GAAP), based on initial patient dosing in January 2016 as part of our Phase III study. This will be settled through the combination of cash paid on Hanmi's behalf to applicable tax authorities, and the issuance of 318,750 of our common shares to Hanmi. This value was recognized within "research and development" expense in accompanying Condensed Consolidated Statement of Operations for the three months ended March 31, 2016. We also will be responsible for milestones relating to regulatory approvals and sales thresholds (aggregating $238 million ), which are not included within "total liabilities" in our Condensed Consolidated Balance Sheets. We will pay Hanmi royalties in the mid-teen digits on our net sales of SPI-2012. (xiii) POZIOTINIB: In-License Agreement with Hanmi In February 2015, we executed an in-license agreement with Hanmi Pharmaceutical Co., Ltd for POZIOTINIB, a pan-HER inhibitor in Phase 2 clinical trials, requiring our upfront payment for these rights. This drug has shown single agent activity in the treatment of various cancer types during Phase I studies, including breast, gastric, colorectal, and lung cancers. Under the terms of this agreement, we received the exclusive rights to commercialize POZIOTINIB globally, excluding Korea and China. Hanmi, and its development partners, will bear full responsibility for completion of on-going Phase 2 trials in Korea. We will bear full financial responsibility for all other clinical studies. We will pay Hanmi future regulatory and sales-dependent milestones payments (aggregating $358 million ), which are not included within “total liabilities” in our accompanying Condensed Consolidated Balance Sheets. We will pay Hanmi royalties in the low to mid-teen digits on our net sales of POZIOTINIB. (xiv) ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO: Out-License Agreement with Servier In January 2016, we entered into a strategic partnership with Servier Canada, Inc. for the out-licenses of ZEVALIN, FOLOTYN, BELEODAQ, and MARQIBO. We received an aggregate $6 million in upfront payments in the first quarter of 2016 which was recognized within "license fees and service revenue". We will also receive development milestone payments if/when achieved, and a high single-digit royalty on their sales of these products. (c) Service Agreements In connection with the research and development of our drug products, we have entered into contracts with numerous third party service providers, such as radio-pharmacies, distributors, clinical trial centers, clinical research organizations, data monitoring centers, and with drug formulation, development and testing laboratories. The financial terms of these agreements are varied and generally obligate us to pay in stages, depending on achievement of certain events specified in the agreements, such as contract execution, reservation of service or production capacity, actual performance of service, or the successful accrual and dosing of patients. At each period end, we accrue for all services received, with such accruals based on factors such as estimates of work performed, patient enrollment, completion of patient studies and other events. Should we decide to discontinue and/or slow-down the work on any project, the associated costs for those projects would be limited to the extent of the work completed. Generally, we are able to terminate these contracts due to the discontinuance of the related project(s) and thus avoid paying for the services that have not yet been rendered. (d) Supply Agreements We have entered into certain supply agreements, or have issued purchase orders, which require us to make minimum purchases from vendors for the manufacture of our products. These commitments do not exceed our planned commercial requirements, and the contracted prices do not exceed their fair market value. (e) Employment Agreement We have entered into an employment agreement with our Chief Executive Officer under which cash compensation and benefits would become payable in the event of termination by us for any reason other than cause, his resignation for good reason, or upon a change in control of our Company. (f) Deferred Compensation Plan The Spectrum Pharmaceuticals, Inc. Deferred Compensation Plan (the “DC Plan”) is administered by the Compensation Committee of our Board of Directors and is intended to comply with the requirements of Section 409A of the Internal Revenue Code of 1986, as amended. The DC Plan is maintained to provide deferred compensation benefits for a select group of our employees (the “DC Participants”). Under the DC Plan, we provide the DC Participants with the opportunity to make annual elections to defer up to a specified amount or percentage of their eligible cash compensation, and we have the option to make discretionary contributions. At March 31, 2016 and December 31, 2015 , the aggregate DC Plan deferrals by employees and our discretionary contributions totaled $7.1 million and $6.5 million , respectively, and are included within “other long-term liabilities” in the accompanying Condensed Consolidated Balance Sheets. (g) Litigation We are involved from time-to-time with various legal matters arising in the ordinary course of business. These claims and legal proceedings are of a nature we believe are normal and incidental to a pharmaceutical business, and may include product liability, intellectual property, employment matters, and other general claims. We make provisions for liabilities when it is both probable that a liability has been incurred and the amount of the loss can be reasonably estimated. Such provisions are assessed at least quarterly and adjusted to reflect the impact of any settlement negotiations, judicial and administrative rulings, advice of legal counsel, and other information and events pertaining to a particular case. Litigation is inherently unpredictable. Although the ultimate resolution of these various matters cannot be determined at this time, we do not believe that such matters, individually or in the aggregate, will have a material adverse effect on our consolidated results of operations, cash flows, or financial condition. We are presently responding to Abbreviated New Drug Applications (“ANDAs”) filed by companies seeking to market generic forms of FOLOTYN. We are also responding to certain stockholder suits that purportedly stem from our March 12, 2013 press release, in which we announced anticipated changes in customer ordering patterns of FUSILEV. These complaints allege that, as a result of this press release, our stock price declined. FUSILEV ANDA Litigation On June 18, 2014, January 23, 2015, July 17, 2015 and September 3, 2015 respectively, we filed suit against Ben Venue Laboratories, Inc., Amneal Pharmaceuticals, Inc., and Actavis LLC. respectively, following Paragraph IV certifications in connection with their filing separate ANDAs, to manufacture a generic version of FUSILEV. We filed the lawsuits in the U.S. District Court for the Districts of Nevada seeking to enjoin the approval of their ANDAs plus recovery of our litigation fees and costs incurred in such matters. On November 24, 2014 the complaint in the Ben Venue case was amended to substitute the original defendant Ben Venue Laboratories, Inc. with successors West-Ward Pharmaceutical Corp. and Eurohealth International SARL. The foregoing matters remain stayed, but unless the Company pursues and is successful in the further appeal of a related case, we anticipate judgment will be entered in favor of the defendants pursuant to stay agreements with such defendants. On April 27, 2015, we filed suit in the U.S. District Court for the District of Columbia against the FDA seeking a temporary restraining order or preliminary injunction to suspend FDA approval of Sandoz’s ANDA. The Company contends that Sandoz’s ANDA should not have been approved until the expiry of the Company’s Orphan Drug Exclusivity on April 29, 2018. On April 29, 2015, the court denied the temporary restraining order and on May 27, 2015, the court entered summary judgment in favor of the FDA et al. On June 5, 2015, we filed our Notice of Appeal. Oral argument was held October 22, 2015. The ultimate outcome of this proceeding is uncertain. FOLOTYN ANDA Litigation On June 19, 2014, we filed a lawsuit against five parties resulting from Paragraph IV certifications in connection with four separate ANDAs to manufacture a generic version of FOLOTYN: (1)Teva Pharmaceuticals USA, Inc., (2) Sandoz Inc., (3) Fresenius Kabi USA, LLC, (4) Dr. Reddy’s Laboratories, Ltd., and (5) Dr. Reddy’s Laboratories, Inc. We filed the lawsuit in the U.S. District Court for the District of Delaware seeking to enjoin the approval of their ANDAs plus recovery of our litigation fees and costs. The litigation is stayed with respect to the Dr. Reddy's entities pending resolution of the case against the other FOLOTYN ANDA filers. A trial date of September 12, 2016 has been set in the FOLOTYN lawsuit in the U.S. District Court for the District of Delaware. While we believe our patent rights are strong, the ultimate outcome of such action is uncertain. Stockholder Litigation John Perry v. Spectrum Pharmaceuticals, Inc. et al. (Filed March 14, 2013 in United States District Court, District of Nevada; Case Number 2:2013-cv-00433-LDG-CWH). This putative consolidated class action raises substantially identical claims and allegations against defendants Spectrum Pharmaceuticals, Inc., Dr. Rajesh C. Shrotriya, Brett L. Scott, and Joseph Kenneth Keller. The alleged class period is August 8, 2012 to March 12, 2013. The lawsuits allege a violation of Section 10(b) of the Securities Exchange Act of 1934 against all defendants and control person liability, as a violation of Section 20(b) of the Securities Exchange Act of 1934, against the individual defendants. The claims purportedly stem from the Company’s March 12, 2013 press release, in which it announced that it anticipated a change in ordering patterns of FUSILEV. The complaints allege that, as a result of the March 12, 2013 press release, the Company’s stock price declined. The complaints further allege that during the putative class period certain defendants made misleadingly optimistic statements about FUSILEV sales, which inflated the trading price of Company stock. The lawsuits seek relief in the form of monetary damages, costs and fees, and any other equitable or injunctive relief that the court deems appropriate. On March 21, 2014, the Court entered an order appointing Arkansas Teacher Retirement System as lead plaintiff. On May 20, 2014, Arkansas Teacher Retirement System filed a consolidated amended class action complaint. On July 18, 2014, we filed a motion to dismiss the consolidated amended class action complaint. On March 26, 2015, the court denied the motion to dismiss. On June 15, 2015, the Court ordered a stay of the proceedings pending the outcome of mediation between the parties. On October 27, 2015, we reached a $7 million settlement in principle with the lead plaintiff (which involved our insurance carrier, as the reimbursing party in full), subject to preliminary and final court approval. We have included this settlement amount, along with $0.2 million of reimbursable legal expenses for this matter, on our accompanying Condensed Consolidated Balance Sheets as of March 31, 2016 within "other receivables" and "accounts payable and other accrued liabilities." On January 26, 2016, the Court preliminarily approved the settlement. The Court has scheduled a hearing on final approval of the settlement for June 13, 2016. Timothy Fik v. Rajesh C. Shrotriya, et al. (Filed April 11, 2013 in United States District Court, District of Nevada; Case Number 2:2013-cv-00624-JCM-CWH); Christopher J. Watkins v. Rajesh C. Shrotriya, et al. (Filed April 22, 2013 in United States District Court, District of Nevada; Case Number 2:2013-cv-00684-JCM-VCF); and Stefan Muenchhagen v. Rajesh C. Shrotriya, et al. (Filed May 28, 2013; Case Number 2:2013-cv-00942-APG-PAL). These derivative complaints are brought by the respective purported stockholders on behalf of nominal plaintiff Spectrum against certain current and former directors and officers. The complaints generally allege breaches of fiduciary based on conduct relating to the events alleged in the consolidated Perry action. The complaints seek compensatory damages, corporate g overnance reforms, restitution and disgorgement of defendants’ alleged profits, and costs and fees. These actions are stayed pending resolution of the federal securities class action. Settlement discussions are ongoing, and accordingly, no agreement has yet been reached to resolve these derivative complaints. If a settlement were reached, it would be reimbursable by our insurance carrier. However, the value of a potential settlement cannot be reasonably estimated given its highly uncertain nature. Hardik Kakadia v. Rajesh C. Shrotriya, et al. (Filed April 23, 2013 in the Eighth Judicial District Court of the State of Nevada in and for Clark County; Case Number A-13-680643-B); and Joel Besner v. Rajesh C. Shrotriya, et al. (Filed May 31, 2013; Case Number A-13-682668-C) (collectively the “State Derivative Actions”). These consolidated State Derivative Actions are brought by the respective purported stockholders on behalf of nominal plaintiff Spectrum Pharmaceuticals, Inc. and are substantially similar to the consolidated federal derivative actions. These actions are stayed pending resolution of the federal securities class action. Settlement discussions are ongoing, and accordingly, no agreement has yet been reached to resolve these derivative complaints. If a settlement were reached, it would be reimbursable by our insurance carrier. However, the value of a potential settlement cannot be reasonably estimated given its highly uncertain nature.

Income Taxes

Income Taxes	3 Months Ended
	Mar. 31, 2016
Income Tax Disclosure [Abstract]
Income Taxes	INCOME TAXES We apply an estimated annual effective tax rate (“ETR”) approach for calculating a tax provision for interim periods, as required under GAAP. We recorded a benefit for income taxes of $0.1 million and a provision for income taxes of $0.1 million for the three months ended March 31, 2016 and 2015 , respectively. Our ETR differs from the U.S. federal statutory tax rate of 35% primarily as a result of nondeductible expenses, state income taxes, foreign income taxes, and the impact of a valuation allowance on our deferred tax assets. Our provision for income taxes is computed using the asset and liability method, under which deferred tax assets and liabilities are recognized for the expected future tax consequences of temporary differences between the financial reporting and tax bases of assets and liabilities, and for the expected future tax benefit to be derived from tax loss and credit carryforwards. Deferred tax assets and liabilities are determined using the enacted tax rates in effect for the years in which those tax assets are expected to be realized. A valuation allowance is established when it is more likely than not the future realization of all or some of the deferred tax assets will not be achieved. The evaluation of the need for a valuation allowance is performed on a jurisdiction by jurisdiction basis, and includes a review of all available positive and negative evidence. We recognize excess tax benefits associated with share-based compensation to stockholders’ equity only when realized. When assessing whether excess tax benefits relating to share-based compensation have been realized, we follow the with-and-without approach, excluding any indirect effects of the excess tax deductions. Under this approach, excess tax benefits related to share-based compensation are not deemed to be realized until after the utilization of all other tax benefits available to us. We recognize the impact of a tax position in our financial statements only if that position is more likely than not of being sustained upon examination by taxing authorities, based on the technical merits of the position. Any interest and penalties related to uncertain tax positions will be reflected in income tax expense.

Description of Business, Basi24

Description of Business, Basis of Presentation, and Operating Segment (Policies)	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Description of Business	(a) Description of Business Spectrum Pharmaceuticals, Inc. (“Spectrum”, the “Company”, “we”, “our”, or “us”) is a biotechnology company, with a primary strategy comprised of acquiring, developing, and commercializing a broad and diverse pipeline of late-stage clinical and commercial products. In addition to an in-house clinical development organization with regulatory and data management capabilities, we have established a commercial infrastructure for our marketed products. Currently, we market six approved oncology/hematology products that target different types of non-Hodgkin's lymphoma ("NHL"), advanced metastatic colorectal cancer, acute lymphoblastic leukemia ("ALL"), and multiple myeloma ("MM"). We also have three drugs in late-stage development: • SPI-2012 for chemotherapy-induced neutropenia in patients with breast cancer. • APAZIQUONE for immediate intravesical instillation in post-transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer. • POZIOTINIB, a novel pan-HER inhibitor used in the treatment of patients with breast cancer.
Basis of Presentation	(b) Basis of Presentation Interim Financial Statements The interim financial data as of March 31, 2016 and 2015 is unaudited, and is not necessarily indicative of our operating results for a full year. In the opinion of our management, the interim data includes normal and recurring adjustments necessary for a fair presentation of our financial results for the three months ended March 31, 2016 and 2015 . Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with generally accepted accounting principles in the United States of America (“GAAP”) have been condensed or omitted pursuant to U.S. Securities and Exchange Commission (“SEC”) rules and regulations relating to interim financial statements. The December 31, 2015 balances reported herein are derived from the audited Consolidated Financial Statements included in our Annual Report on Form 10-K for the year ended December 31, 2015 . The accompanying Condensed Consolidated Financial Statements should be read in conjunction with our audited Consolidated Financial Statements and Notes thereto included in our Annual Report on Form 10-K for the fiscal year ended December 31, 2015 , filed with the SEC on March 14, 2016. Principles of Consolidation The accompanying Condensed Consolidated Financial Statements have been prepared in accordance with GAAP and with the rules and regulations of the U.S. Securities and Exchange Commission ("SEC"). These financial statements include the financial position, results of operations, and cash flows of Spectrum and its subsidiaries, all of which are wholly-owned (except for SPC, as discussed below). All inter-company accounts and transactions among these legal entities have been eliminated in consolidation. Variable Interest Entity We own fifty -percent of Spectrum Pharma Canada (“SPC”), a legal entity organized in Quebec, Canada in January 2008. Certain of our drug clinical studies are conducted through this “variable interest entity” (as defined under applicable GAAP) and we fund all of SPC’s operating costs. Since we carry the full risks and rewards of SPC, we meet the applicable GAAP criteria as being its “primary beneficiary.” Accordingly, SPC’s balance sheets and statements of operations are included in our Condensed Consolidated Financial Statements as if it were a wholly-owned subsidiary for all periods presented.
Operating Segment	(c) Operating Segment We operate in one reportable operating segment that is focused exclusively on developing and commercializing oncology and hematology drug products. For the three months ended March 31, 2016 and 2015 , all of our revenue and related expenses were solely attributable to these activities. Substantially all of our assets (excluding our cash held in certain foreign bank accounts and our ZEVALIN distribution rights for the Ex-U.S. territory) are held in the U.S.
Revenue Recognition	(i) Revenue Recognition (a) Product Sales : We sell our products to wholesalers/distributors (i.e., our customers), except for our U.S. sales of ZEVALIN in which case the end-user (i.e. clinic or hospital) is our customer. Our wholesalers/distributors in turn sell our products directly to clinics, hospitals, and private oncology-based practices. Revenue from our product sales is recognized when title and risk of loss have transferred to our customer, and the following additional criteria are met: (1) appropriate evidence of a binding arrangement exists with our customer; (2) price is substantially fixed and determinable; (3) collection from our customer is reasonably assured; (4) our customer’s obligation to pay us is not contingent on resale of the product; (5) we do not have significant continued performance obligations to our customer; and (6) we have a reasonable basis to estimate returns. Our gross revenue is reduced by our gross-to-net (“GTN”) estimates each period, resulting in our reported “product sales, net” in the accompanying Condensed Consolidated Statements of Operations. We defer revenue recognition in full if these estimates are not reasonably determinable at the time of sale. These estimates are based upon information received from external sources (such as written and oral information obtained from our customers with respect to their period-end inventory levels, and their sales to end-users during the period), in combination with management’s informed judgments. Due to the inherent uncertainty of estimates, the actual amount we incur may be materially different than our GTN estimates, and require prospective revenue adjustments in periods after the initial sale was recorded. Our GTN estimates are comprised of the following categories: Product Returns Allowances : Our FUSILEV, MARQIBO, and BELEODAQ customers are permitted to return purchased product beginning at its expiration date, and within six months thereafter. Returned product is generally not resold. Returns for expiry of ZEVALIN and FOLOTYN are not contractually, or customarily, allowed. We estimate expected returns based on our historical return rates. Government Chargebacks : Our products are subject to pricing limits under certain federal government programs (e.g., Medicare and 340B Drug Pricing Program). Qualifying entities (i.e., end-users) purchase product from our customers at their qualifying discounted price. The chargeback amount we incur represents the difference between our contractual sales price to our customer, and the end-user’s applicable discounted purchase price under the government program. There may be significant lag time between our reported net product sales and our receipt of corresponding government chargeback claims from our customers. Prompt Pay Discounts : Discounts for prompt payment are estimated at the time of sale, based on our eligible customers’ prompt payment history and the contractual discount percentage. Commercial Rebates : Commercial rebates are based on (i) our estimates of end-user purchases through a group purchasing organization ("GPO"), (ii) the corresponding contractual rebate percentage tier we expect each GPO to achieve, and (iii) our estimates of the impact of any prospective rebate program changes made by us. Medicaid Rebates : Our products are subject to state government-managed Medicaid programs, whereby rebates are issued to participating state governments. These rebates arise when a patient treated with our product is covered under Medicaid, resulting in a discounted price for our product under the applicable Medicaid program. Our Medicaid rebate accrual calculations require us to project the magnitude of our sales, by state, that will be subject to these rebates. There is a significant time lag in us receiving rebate notices from each state (generally several months or longer after our sale is recognized). Our estimates are based on our historical claim levels by state, as supplemented by management’s judgment. Distribution, Data, and GPO Administrative Fees : Distribution, data, and GPO administrative fees are paid to authorized wholesalers/distributors of our products (except for U.S. sales of ZEVALIN) for various commercial services, including: contract administration, inventory management, delivery of end-user sales data, and product returns processing. These fees are based on a contractually-determined percentage of our applicable sales. (b) License Fees : We recognize revenue for our licensing of intellectual property to third-parties (out-licenses), based on the contractual terms of each agreement and our application of pertinent GAAP. This revenue may be associated with upfront license fees, milestone payments from our licensees’ sales or regulatory achievements, and royalties from our licensees’ sales in applicable territories. (c) Service Revenue : We receive fees from third-parties under certain arrangements for our sales and marketing services, research and development activities, clinical trial management, and supply chain services. Payment may be triggered by contractual fixed payment schedules, the successful completion of a phase of development, results from a clinical trial, regulatory approval events, or completion of product delivery in our capacity as an agent in such arrangement. We recognize revenue when the corresponding milestone is achieved, or the revenue is otherwise earned and due to us through our on-going activities. (d) New Revenue Recognition Standard : On April 1, 2015, the FASB voted for a one-year deferral of the effective date of the new revenue recognition standard, ASU No. 2014-09, Revenue from Contracts with Customers (Topic 606) (“ASU 2014-09”). ASU 2014-09 is now effective for us beginning January 1, 2018, requiring revenue recognition in a manner that reasonably reflects the delivery of our goods or services to customers in return for expected consideration. To achieve this core principle, the guidance provides the following steps: (1) identify the contract(s) with a customer; (2) identify the performance obligations in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligations in the contract; and (5) recognize revenue when (or as) the entity satisfies a performance obligation. We intend to apply the cumulative effect transition method of ASU 2014-09, and we continue to evaluate the impact of this new standard on our current revenue recognition models for product sales , license fees , and service revenue , as described above.
Cash and Equivalents	(ii) Cash and Equivalents Our cash and equivalents consist of bank deposits and highly liquid investments with maturities of three months or less from the purchase date.
Marketable Securities	(iii) Marketable Securities Our marketable securities consist of our holdings in mutual funds and bank certificates of deposit. Since we classify these securities as “available-for-sale” under applicable GAAP, any unrealized gains or losses from their change in value is reflected in “unrealized gain on available-for-sale securities” on the accompanying Condensed Consolidated Statements of Comprehensive Loss. Realized gains and losses on available-for-sale securities are included in “other income (expense), net” on the accompanying Condensed Consolidated Statements of Operations.
Accounts Receivable	(iv) Accounts Receivable Our accounts receivables are derived from our product sales and license fees (our service revenue is recorded in "other receivables"), and do not bear interest. The allowance for doubtful accounts is management’s best estimate of the amount of probable credit losses in our existing accounts receivable. Account balances are charged off against the allowance after appropriate collection efforts are exhausted.
Inventories	(v) Inventories We value our inventory at the lower of (i) the actual cost of its purchase or manufacture, or (ii) its current market value. Inventory cost is determined on the first-in, first-out method ("FIFO"). We regularly review our inventory quantities in process of manufacture and on hand. When appropriate, we record a provision for obsolete and excess inventory to derive its new cost basis, which takes into account our sales forecast by product and corresponding expiry dates. Direct and indirect manufacturing costs related to the production of inventory prior to U.S. Food and Drug Administration ("FDA") approval are expensed through “research and development,” rather than being capitalized to inventory cost.
Property and Equipment	(vi) Property and Equipment Our property and equipment is stated at historical cost, and is depreciated on a straight-line basis over an estimated useful life that corresponds with its designated asset category. We evaluate the recoverability of “long-lived assets” (which includes property and equipment) whenever events or changes in circumstances in our business indicate that the asset’s carrying amount may not be recoverable through on-going operations.
Goodwill and Intangible Assets	(vii) Goodwill and Intangible Assets Our goodwill represents the excess of our business acquisition cost over the estimated fair value of the net assets acquired in the corresponding transaction. Goodwill has an indefinite accounting life and is therefore not amortized. Instead, goodwill is evaluated for impairment on an annual basis (as of each October 1 st ), unless we identify impairment indicators that would require earlier testing. We evaluate the recoverability of indefinite-lived intangible assets at least annually, or whenever events or changes in our business indicate that an intangible asset’s (whether indefinite or definite-lived) carrying amount may not be recoverable. Such circumstances could include, but are not limited to the following: (a) a significant decrease in the market value of an asset; (b) a significant adverse change in the extent or manner in which an asset is used; or (c) an accumulation of costs significantly in excess of the amount originally expected for the acquisition of an asset. Intangible assets with finite useful lives are amortized over their estimated useful lives on a straight-line basis. We review these assets for potential impairment if/when facts or circumstances suggest that the carrying value of these assets may not be recoverable.
Stock-Based Compensation	(viii) Stock-Based Compensation Stock-based compensation expense for equity awards granted to our employees and members of our board of directors is recognized on a straight-line basis over each award's vesting period. Recognized compensation expense is net of an estimated forfeiture rate, representing the percentage of awards that are expected to be forfeited (by termination of employment or service) prior to vesting. We use the Black-Scholes option pricing model to determine the fair value of stock options (as of the date of grant) which carry service conditions for vesting. When applicable, we use the Monte Carlo valuation model to value equity awards (as of the date of grant) which carry combined market conditions and service conditions for vesting. The calculation of the fair value of stock options on the date of grant, and the recognition of stock-based compensation expense over the appropriate time period, requires uncertain assumptions, including (a) the pre-vesting forfeiture rate of the stock option, (b) the term of the stock option, (c) the stock price volatility over the term of the stock option, and (d) the risk-free interest rate over the term of the stock option. We estimate forfeiture rates based on our employees’ overall forfeiture history, which we believe will be representative of future results. We estimate the expected term of stock options granted based on our employees’ historical exercise patterns, which we believe will be representative of their future behavior. We estimate the volatility of our common stock on the date of grant based on historical volatility of our common stock for a look-back period that corresponds with the expected term. We estimate the risk-free interest rate based upon the U.S. Treasury yields in effect at award grant, for a period equaling the stock options’ expected term.
Foreign Currency Transactions and Translation	(ix) Foreign Currency Translation We translate the assets and liabilities of our foreign subsidiaries that are stated in their functional currencies (i.e., local operating currencies), to U.S. dollars at the rates of exchange in effect at the reported balance sheet date. Revenues and expenses are translated using the monthly average exchange rates during the reported period. Unrealized gains and losses from the translation of our subsidiaries’ financial statements (that are initially denominated in the corresponding functional currency) are included as a separate component of “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. We record foreign currency transactions, when initially denominated in a currency other than the respective functional currency of our subsidiary, at the prevailing exchange rate on the date of the transaction. Resulting unrealized foreign exchange gains and losses from transactions with third parties are included in “accumulated other comprehensive loss” in the Condensed Consolidated Balance Sheets. All unrealized foreign exchange gains and losses associated with our intercompany loans are included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets, as these loans with our foreign subsidiaries are not expected to be settled in the "foreseeable future." For the period January 1, 2015 through March 31, 2015, unrealized foreign exchange gains and losses associated with our intercompany loans were included in "accumulated other comprehensive loss" in the Condensed Consolidated Balance Sheets and in "other income (expense), net" in the Condensed Consolidated Statements of Operations. In periods prior to January 1, 2015, all unrealized foreign exchange gains and losses associated with intercompany loans were included in “other income (expense), net” in the Condensed Consolidated Statements of Operations.
Basic and Diluted Net (Loss) Income per Share	(x) Basic and Diluted Net (Loss) Income per Share We calculate basic and diluted net (loss) income per share using the weighted average number of common shares outstanding during the periods presented. In periods of a net loss, basic and diluted loss per share are the same. For the diluted earnings per share calculation, we adjust the weighted average number of common shares outstanding to include only dilutive stock options, warrants, and other common stock equivalents outstanding during the period.
Income Taxes	(xi) Income Taxes Deferred tax assets and liabilities are recorded based on the estimated future tax effects of temporary differences between the tax basis of assets and liabilities and amounts reported in the financial statements, as well as operating losses and tax credit carry forwards using enacted tax rates and laws that are expected to be in effect when the differences are expected to reverse. Realization of deferred tax assets is dependent upon future earnings, the timing and amount of which are uncertain. We have recorded a valuation allowance to reduce our deferred tax assets, because we believe that, based upon a weighting of positive and negative factors, it is more likely than not that these deferred tax assets will not be realized. If/when we determine that our deferred tax assets are realizable, an adjustment to the corresponding valuation allowance would increase our net income in the period that such determination was made. In the event that we are assessed interest and/or penalties from taxing authorities that have not been previously accrued, such amounts would be included in “benefit (provision) for income taxes” within the Condensed Consolidated Statements of Operations in the period the notice was received.
Research and Development Costs	(xii) Research and Development Costs Our research and development costs are expensed as incurred, or as certain milestone payments become due, generally triggered by clinical or regulatory events.
Fair Value Measurements	(xiii) Fair Value Measurements We determine measurement-date fair value based on the proceeds that would be received through the sale of the asset, or that we would pay to settle or transfer the liability, in an orderly transaction between market participants. We utilize valuation techniques that maximize the use of observable inputs and minimize the use of unobservable inputs to the extent possible. Fair value measurements are based on a three-tier hierarchy that prioritizes the inputs used in descending order to measure fair value. These tiers include the following: Level 1: Quoted prices (unadjusted) in active markets for identical assets or liabilities that are publicly accessible at the measurement date. Level 2: Observable prices that are based on inputs not quoted on active markets, but that are corroborated by market data. These inputs may include quoted prices for similar assets or liabilities or quoted market prices in markets that are not active to the general public. Level 3: Unobservable inputs are used when little or no market data is available.

Balance Sheet Account Detail (T

Balance Sheet Account Detail (Tables)	3 Months Ended
	Mar. 31, 2016
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Cash And Cash Equivalent Marketable Securities Unrealized Gain Table	The following is a summary of our “cash and cash equivalents” and “marketable securities”: Marketable Securities Cost Gross Gross Estimated Cash and Cash Current Long March 31, 2016 Bank deposits $ 52,160 $ — $ — $ 52,160 $ 52,160 $ — $ — Money market funds 80,146 — — 80,146 80,146 — — Bank certificates of deposits 246 — — 246 — 246 — Mutual funds — — — — — — — Total cash and equivalents and marketable securities $ 132,552 $ — $ — $ 132,552 $ 132,306 $ 246 $ — December 31, 2015 Bank deposits $ 59,625 $ — $ — $ 59,625 $ 59,625 $ — $ — Money market funds 80,116 — — 80,116 80,116 — — Bank certificates of deposits 245 — — 245 — 245 — Mutual funds — — — — — — — Total cash and equivalents and marketable securities $ 139,986 $ — $ — $ 139,986 $ 139,741 $ 245 $ —
Schedule of Property and Equipment Net of Accumulated Depreciation	“Property and equipment, net of accumulated depreciation” consist of the following: March 31, 2016 December 31, 2015 Computer hardware and software $ 3,824 $ 3,785 Laboratory equipment 622 608 Office furniture 355 355 Leasehold improvements 2,880 2,872 Property and equipment, at cost 7,681 7,620 (Less): Accumulated depreciation (6,871 ) (6,702 ) Property and equipment, net of accumulated depreciation $ 810 $ 918
Components of Inventories	“Inventories” consist of the following: March 31, 2016 December 31, 2015 Raw materials $ 1,782 $ 1,606 Work-in-process* 7,457 4,228 Finished goods 839 1,498 (Less:) Non-current portion of inventories included within "other assets" ** (6,923 ) (3,156 ) Inventories $ 3,155 $ 4,176 * In January 2016, we received $3.4 million of ZEVALIN antibody materials for its future manufacture (representing strategic long-term supply). ** The "non-current" portion of inventories is presented within "other assets" in the accompanying Condensed Consolidated Balance Sheet at March 31, 2016 . This value of $6.9 million represents product that we expect to sell beyond March 31, 2017.
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure	“Prepaid expenses and other assets” consist of the following: March 31, 2016 December 31, 2015 Prepaid operating expenses $ 2,352 $ 3,507 Current portion of debt issuance costs* — — Prepaid expenses and other assets $ 2,352 $ 3,507 * Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith the FASB-issued Accounting Standards Update 2015-03, Simplifying the Presentation of Debt Issuance Costs (“ASU 2015-03”). These amounts were $2.0 million and $2.2 million (including current and non-current portions) as of March 31, 2016 and December 31, 2015, respectively.
Schedule of Other Receivables	“Other receivables” consist of the following: March 31, 2016 December 31, 2015 Income tax receivable $ 754 $ 1,301 Insurance receivable 7,188 7,100 Mundipharma promissory note 2,347 2,215 CASI note - short term* 1,500 — Eagle service revenue and support costs 1,450 — Research and development expenses - reimbursements due 1,617 1,699 Other miscellaneous receivables 319 257 Other receivables $ 15,175 $ 12,572 * This full balance was prospectively reclassified as of March 31, 2016 to "other receivables" (presented within current assets on the accompanying Condensed Consolidated Balance Sheets) from "other assets" (presented within non-current assets) due to this note's maturity date of March 17, 2017 (i.e., within 12 months of March 31, 2016) - see Note 10 .
Components of Intangible Assets Net of Accumulated Amortization	“Intangible assets, net of accumulated amortization and impairment charges” consist of the following: March 31, 2016 Historical Accumulated Foreign Impairment Net Amount Full Remaining MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 n/a n/a EVOMELA distribution rights (1) 7,700 — — — 7,700 156 156 BELEODAQ distribution rights 25,000 (3,281 ) — — 21,719 160 139 MARQIBO distribution rights 26,900 (9,624 ) — — 17,276 81 48 FOLOTYN distribution rights 118,400 (31,834 ) — — 86,566 152 110 ZEVALIN distribution rights – U.S. 41,900 (31,477 ) — — 10,423 123 36 ZEVALIN distribution rights – Ex-U.S. 23,490 (13,543 ) (3,566 ) — 6,381 96 48 FUSILEV distribution rights (2) 16,778 (9,618 ) — (7,160 ) — 56 0 FOLOTYN out-license (3) 27,900 (9,789 ) — (1,023 ) 17,088 110 76 Total intangible assets $ 305,668 $ (109,166 ) $ (3,566 ) $ (8,183 ) $ 184,753 (1) The FDA approval of EVOMELA in March 2016 triggered a $6 million payment due to CyDex Pharmaceuticals, Inc. (a wholly-owned subsidiary of Ligand Pharmaceuticals Incorporated). This event also resulted in a reclassification of our $7.7 million "EVOMELA IPR&D" to "EVOMELA distribution rights" due to our ability to begin its commercialization with this FDA approval. In accordance with our capitalization policy for intangible assets, amortization will commence on the first day of the following month of this reclassification (i.e., April 1, 2016). (2) On February 20, 2015, the U.S. District Court for the District of Nevada found the patent covering FUSILEV to be invalid, which was upheld on appeal. On April 24, 2015, Sandoz began to commercialize a generic version of FUSILEV. This represented a “triggering event” under applicable GAAP in evaluating the value of our FUSILEV distribution rights as of March 31, 2015, resulting in a $7.2 million impairment charge (non-cash) in the first quarter of 2015. We accelerated amortization expense recognition in 2015 for the remaining net book value of FUSILEV distribution rights. (3) On May 29, 2013, we amended our FOLOTYN collaboration agreement with Mundipharma. As a result of the amendment, Europe and Turkey were excluded from Mundipharma’s commercialization territory, and their royalty rates and milestone payments to us were modified. This constituted a change under which we originally valued the FOLOTYN out-license as part of business combination accounting, resulting in an impairment charge (non-cash) of $1.0 million in the second quarter of 2013. December 31, 2015 Historical Accumulated Foreign Impairment Net Amount MARQIBO IPR&D (NHL and other novel indications) $ 17,600 $ — $ — $ — $ 17,600 EVOMELA IPR&D 7,700 — — — 7,700 BELEODAQ distribution rights 25,000 (2,812 ) — — 22,188 MARQIBO distribution rights 26,900 (8,544 ) — — 18,356 FOLOTYN distribution rights 118,400 (29,474 ) — — 88,926 ZEVALIN distribution rights – U.S. 41,900 (30,608 ) — — 11,292 ZEVALIN distribution rights – Ex-U.S. 23,490 (12,632 ) (4,353 ) — 6,505 FUSILEV distribution rights 16,778 (9,618 ) — (7,160 ) — FOLOTYN out-license 27,900 (9,109 ) — (1,023 ) 17,768 Total intangible assets $ 305,668 $ (102,797 ) $ (4,353 ) $ (8,183 ) $ 190,335
Estimated Intangible Asset Amortization Expense	Estimated intangible asset amortization expense for the remainder of 2016 and the five succeeding fiscal years and thereafter is as follows: Years Ending December 31, Remainder of 2016 $ 18,017 2017 24,023 2018 24,023 2019 21,417 2020 16,113 2021 14,634 2022 and thereafter 48,926 $ 167,153
Schedule of Goodwill	“Goodwill” is comprised of the following: March 31, 2016 December 31, 2015 Acquisition of Talon (MARQIBO rights) $ 10,526 $ 10,526 Acquisition of ZEVALIN Ex-U.S. distribution rights 2,525 2,525 Acquisition of Allos (FOLOTYN rights) 5,346 5,346 Foreign currency exchange translation effects (353 ) (437 ) Goodwill $ 18,044 $ 17,960
Summary of Other Assets	“Other assets” are comprised of the following: March 31, 2016 December 31, 2015 Equity securities and secured promissory note - CASI (see Note 10)* $ 7,520 $ 6,689 Supplies and deposits** 1,165 185 2018 Convertible Notes issuance costs (excluding current portion)*** — — Executive officer life insurance – cash surrender value 9,651 9,181 Inventories - non-current portion 6,923 3,156 Other miscellaneous assets 45 — Other assets $ 25,304 $ 19,211 * These equity securities were excluded from “marketable securities” (see Note 3(a) ) due to our intent to hold these securities for at least one year beyond March 31, 2016 , as discussed in Note 10 . Unrealized gains from these equity securities were recognized through “unrealized gain on available-for-sale securities" within the Condensed Consolidated Statements of Comprehensive Loss, and were $1.4 million for the three months ended March 31, 2016 . ** Of this balance at March 31, 2016, $1.0 million relates to ZEVALIN inventories that we intend to consume in research and development activities in future periods as part of our new contract manufacturer validation process. Accordingly, we have presented this value within "other assets" rather than "inventories" due to our present intention for these units. *** Beginning January 1, 2016, our debt issuance costs (current and non-current portions) were retrospectively reclassified from “prepaid expenses and other assets” and "other assets" to a reduction of the carrying amount of “convertible senior notes” (i.e., contra-liability - see Note 14 ) within our accompanying Consolidated Balance Sheets, in accordance w ith ASU 2015-03. These amounts were $2.0 million and $2.2 million (including current and non-current portions) as of March 31, 2016 and December 31, 2015, respectively.
Schedule of Accounts Payable and Other Accrued Liabilities	“Accounts payable and other accrued liabilities” are comprised of the following : March 31, 2016 December 31, 2015 Trade accounts payable and other accrued liabilities $ 31,922 $ 26,684 Accrued rebates 6,978 18,166 Accrued product royalty 4,076 4,908 Allowance for returns 1,429 1,394 Accrued data and distribution fees 1,126 1,830 Accrued GPO administrative fees 521 1,058 Accrued inventory management fee 210 498 Allowance for chargebacks 1,241 2,001 Accounts payable and other accrued liabilities $ 47,503 $ 56,539
Schedule of Amounts Presented in Accounts Payable and Other Accrued Liabilities	Amounts presented within “accounts payable and other accrued liabilities” in the accompanying Condensed Consolidated Balance Sheets specifically for gross-to-net ("GTN") estimates (see Note 2(i) ) are as follows: Rebates and Data and Returns Balance as of December 31, 2014 $ 45,822 $ 8,284 $ 1,135 Add: provisions 75,498 15,928 1,486 (Less): credits or actual allowances (101,153 ) (20,826 ) (1,227 ) Balance as of December 31, 2015 20,167 3,386 1,394 Add: provisions 19,952 2,227 590 (Less): credits or actual allowances (31,900 ) (3,755 ) (555 ) Balance as of March 31, 2016 $ 8,219 $ 1,858 $ 1,429
Deferred Revenue, by Arrangement, Disclosure	Deferred revenue (current and non-current) is comprised of the following: March 31, 2016 December 31, 2015 Mundipharma deferred revenue (see Note 11 ) $ 2,472 $ — FUSILEV deferred revenue* — 6,083 Dr. Reddy's out-license (see Note 16(b)(iii) ) 436 430 Deferred revenue $ 2,908 $ 6,513 * In the third quarter 2015, we deferred revenue recognition related to certain FUSILEV product shipments that did not meet our revenue recognition criteria (see Note 2(i)(a )), aggregating $9.9 million . Specifically, this deferral resulted from our inability to concurrently estimate future rebate values (with requisite precision) offered to our customers in order to compete with generic products. During the fourth quarter of 2015, we recognized $3.8 million for these third quarter shipments, and $6.1 million remained deferred as of December 31, 2015 . In the first quarter 2016, this $6.1 million of deferred revenue was recognized in full.
Summary of Other Long-Term Liabilities	Other long-term liabilities are comprised of the following: March 31, 2016 December 31, 2015 Accrued executive deferred compensation $ 7,117 $ 6,458 Deferred rent (non-current portion) 235 248 Clinical study holdback costs, non-current 19 — Other tax liabilities 738 738 Other long-term liabilities $ 8,109 $ 7,444

Gross-to-Net Product Sales (Tab

Gross-to-Net Product Sales (Tables)	3 Months Ended
	Mar. 31, 2016
Revenue, Net [Abstract]
Reconciliation of Gross to Net Product Sales	The below table presents a GTN product sales reconciliation for the accompanying Condensed Consolidated Statement of Operations: Three Months Ended 2016 2015 Gross product sales $ 58,011 $ 62,598 Commercial rebates and government chargebacks (19,953 ) (18,144 ) Data and distribution fees, GPO fees, and inventory management fees (2,227 ) (5,571 ) Product returns allowance (590 ) (470 ) Net product sales $ 35,241 $ 38,413

Net Product Sales by Geograph27

Net Product Sales by Geographic Region and Product Line (Tables)	3 Months Ended
	Mar. 31, 2016
Segment Reporting [Abstract]
Schedule of Product Sales, Net by Geography	The below table presents our net product sales by geography for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 United States $ 33,779 95.9 % $ 36,546 95.1 % International: Europe 1,462 4.1 % 644 1.7 % Asia Pacific* — — % 1,223 3.2 % Total international 1,462 4.1 % 1,867 4.9 % Net product sales $ 35,241 100.0 % $ 38,413 100.0 % * See Note 11 for discussion of our November 2015 out-license for Asia Pacific territory to Mundipharma.
Schedule Of Net Sales By Product Line Table	The below table presents our net product sales by product line for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 FUSILEV $ 15,209 43.2 % $ 20,167 52.5 % FOLOTYN 13,292 37.7 % 9,316 24.3 % ZEVALIN 2,783 7.9 % 4,223 11.0 % MARQIBO 929 2.6 % 1,893 4.9 % BELEODAQ 3,028 8.6 % 2,814 7.3 % Net product sales $ 35,241 100.0 % $ 38,413 100.0 %

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	3 Months Ended
	Mar. 31, 2016
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]
Summary of Stock-Based Compensation Expense	Stock-based compensation expense included within “Total operating costs and expenses” for the three months ended March 31, 2016 and 2015 was as follows: Three Months Ended 2016 2015 Cost of product sales $ 27 $ — Research and development 381 433 Selling, general and administrative 2,769 2,029 Total stock-based compensation $ 3,177 $ 2,462

Net Loss Per Share (Tables)

Net Loss Per Share (Tables)	3 Months Ended
	Mar. 31, 2016
Earnings Per Share [Abstract]
Computation of Net Loss Per Share	Net loss per share was computed by dividing net loss by the weighted average number of common shares outstanding for the three months ended March 31, 2016 and 2015 : Three Months Ended 2016 2015 Net loss $ (9,321 ) $ (25,562 ) Weighted average shares – basic and diluted 65,597,261 64,880,677 Net loss per share – basic and diluted $ (0.14 ) $ (0.39 )
Schedule of Securities Excluded from Calculation of Net Loss Per Share	The below outstanding securities were excluded from the above calculation of net loss per share because their impact would have been anti-dilutive due to net loss per share in the three months ended March 31, 2016 and 2015 , as summarized below: Three Months Ended 2016 2015 2018 Convertible Notes 11,401,284 11,401,284 Common stock options 982,748 1,825,868 Restricted stock awards 2,592,614 1,528,815 Common stock warrants — 71,227 Preferred stock 40,000 40,000 Total 15,016,646 14,867,194

Fair Value Measurements (Tables

Fair Value Measurements (Tables)	3 Months Ended
	Mar. 31, 2016
Fair Value Disclosures [Abstract]
Summary of Asset and Liability Fair Values	The table below summarizes certain asset and liability fair values that are included within our accompanying Condensed Consolidated Balance Sheets, and their designations among three fair value measurement categories: March 31, 2016 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 246 $ — $ 246 Money market currency funds — 80,146 — 80,146 Equity securities 7,520 — — 7,520 Secured promissory note — — — — Mutual funds — 45 — 45 Deferred compensation investments, including life insurance cash surrender value — 9,651 — 9,651 $ 7,520 $ 90,088 $ — $ 97,608 Liabilities: Deferred executive compensation liability $ — $ 7,117 $ — $ 7,117 Deferred drug development liability — — 14,510 14,510 Ligand Contingent Consideration — — 6,000 6,000 Talon CVR — — 1,646 1,646 Corixa Liability — — 62 62 $ — $ 7,117 $ 22,218 $ 29,335 December 31, 2015 Level 1 Level 2 Level 3 Total Assets: Bank certificates of deposits $ — $ 245 $ — $ 245 Money market currency funds — 80,116 — 80,116 Equity securities 5,189 — — 5,189 Deferred compensation investments, including life insurance cash surrender value — 9,181 — 9,181 $ 5,189 $ 89,542 $ — $ 94,731 Liabilities: Deferred executive compensation liability $ — $ 6,458 $ — $ 6,458 Deferred drug development costs — — 14,686 14,686 Ligand Contingent Consideration — — 5,227 5,227 Talon CVR — — 1,377 1,377 Corixa Liability — — 62 62 $ — $ 6,458 $ 21,352 $ 27,810
Fair Value Measurement Activity for Liabilities Utilize Level 3 Inputs	The following presents a roll forward of our liabilities for which we utilize Level 3 inputs in determining period-end value. These liabilities are included on our Condensed Consolidated Balance Sheets within “acquisition-related contingent obligations” and “drug development liability”. The basis of the various Level 3 valuation inputs are discussed in the Notes to these accompanying Condensed Consolidated Financial Statements. Our carrying amounts of financial instruments such as cash equivalents, accounts receivable, prepaid expenses, accounts payable, and accrued liabilities, excluding acquisition-related contingent obligations, approximate their related fair values due to their short-term nature. Fair Value Measurements of Balance at December 31, 2014 $ 23,127 Deferred drug development costs (1,099 ) Ligand Contingent Consideration 326 Talon CVR (1,002 ) Corixa Liability — Balance at December 31, 2015 21,352 Deferred drug development costs (see Note 15 ) (176 ) Ligand Contingent Consideration (see Note 9(b)) 773 Talon CVR (see Note 9(a)) 269 Corixa Liability (see Note 16(b)(i) ) — Balance at March 31, 2016* $ 22,218 * This amount is comprised of the current and non-current portions of “drug development liability” and “acquisition-related contingent obligations” on our accompanying Condensed Consolidated Balance Sheets.

Business Combinations and Con31

Business Combinations and Contingent Consideration (Tables)	3 Months Ended
	Mar. 31, 2016
Talon Therapeutics, Inc. [Member]
Change in Fair Value of Contingent Consideration Related to Acquisitions	Fair Value December 31, 2015 $ 1,377 Fair value adjustment for the three months ended March 31, 2016 269 March 31, 2016 $ 1,646
Acquisition-Date Fair Value of Consideration Transferred	The acquisition-date fair value of the consideration transferred consisted of the following: Cash consideration $ 3,000 Ligand Contingent Consideration 4,700 Total purchase consideration $ 7,700
Melphalan license [Member]
Change in Fair Value of Contingent Consideration Related to Acquisitions	Fair Value of December 31, 2015 $ 5,227 Fair value adjustment for the three months ended March 31, 2016 773 March 31, 2016 $ 6,000
Summary of Allocation of Total Purchase Price to Net Assets Acquired	The allocation of the total purchase price to the net assets acquired is as follows: EVOMELA IPR&D $ 7,700

Out-License of Marqibo, Zeval32

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI (Tables)	3 Months Ended
	Mar. 31, 2016
Other Commitments [Abstract]
Schedule of Proceeds Received and Fair Value on CASI Out-License Execution Date	The proceeds we received, and its fair value on the CASI Out-License execution date, consisted of the following: CASI common stock (5.4 million shares) $ 8,649 (a) CASI secured promissory note due March 17, 2017, net of fair value discount ($1.5 million face value and 0.5% annual coupon) 1,310 (b) Total consideration received, net of fair value discount $ 9,959 (a) Value determined based on the September 17, 2014 closing price of 5.4 million shares of CASI common stock on the NASDAQ Capital Market of $1.60 per share. Our current intention is to hold these securities on a long-term basis. Accordingly, we have presented its value of $7.5 million as of March 31, 2016 within "other assets" (rather than "marketable securities") on our accompanying Condensed Consolidated Balance Sheets. The change in fair value of these securities is reported within “unrealized gain on available-for-sale securities" on the Condensed Consolidated Statements of Comprehensive Loss. (b) Value estimated using the terms of the $1.5 million promissory note, the application of a synthetic debt rating based on CASI’s publicly-available financial information, and the prevailing interest yields on similar public debt securities as of September 17, 2014. The face value of the promissory note as of March 31, 2016 is included within "other receivables" on the accompanying Condensed Consolidated Balance Sheets.

Convertible Senior Notes (Table

Convertible Senior Notes (Tables)	3 Months Ended
	Mar. 31, 2016
Debt Disclosure [Abstract]
Carrying Value of 2018 Convertible Notes	The carrying value of the 2018 Convertible Notes as of March 31, 2016 is summarized as follows: Principal amount $ 120,000 (Less): Unamortized debt discount (amortized through December 2018) (17,067 ) (Less): Debt issuance costs (see Note 3(d) ) (2,000 ) March 31, 2016 carrying value $ 100,933
Components of the Interest Expense Recognized	The following table sets forth the components of interest expense recognized in the accompanying Condensed Consolidated Statements of Operations for the 2018 Convertible Notes for the three months ended March 31, 2016 : Contractual coupon interest expense $ 825 Amortization of debt issuance costs 171 Accretion of debt discount 1,385 Total $ 2,381 Effective interest rate 8.66 %

Mundipharma Agreement And Dru34

Mundipharma Agreement And Drug Development Liability (Tables)	3 Months Ended
	Mar. 31, 2016
Business Combinations [Abstract]
Schedule of Drug Development Liability Adjustments	Drug Drug Total Drug Balance at December 31, 2015 $ 259 $ 14,427 $ 14,686 Transfer from long-term to current in 2016 74 (74 ) — (Less): Expenses incurred in 2016 (176 ) — (176 ) Balance at March 31, 2016 $ 157 $ 14,353 $ 14,510

Description of Business, Basi35

Description of Business, Basis of Presentation, and Operating Segment - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2016Segmentproduct
Segment Reporting Information [Line Items]
Number of late stage development products	3
Number of reportable operating segment | Segment	1
Spectrum Pharma Canada [Member]
Segment Reporting Information [Line Items]
Ownership interest, percentage	50.00%
Cancer Drugs [Member]
Segment Reporting Information [Line Items]
Number of products for sale	6

Use of Estimates and Summary 36

Use of Estimates and Summary of Significant Accounting Policies - Additional Information (Detail)	3 Months Ended
	Mar. 31, 2016
Accounting Policies [Abstract]
Number of months customers are allowed to return products	6 months
Cash and equivalents maturities period	3 months

Balance Sheet Account Detail -

Balance Sheet Account Detail - Summary of Cash and Cash Equivalents and Marketable Securities (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015	Mar. 31, 2015	Dec. 31, 2014
Schedule of Investments [Line Items]
Cash and cash equivalents, Marketable securities, Cost	$ 132,552	$ 139,986
Cash and cash equivalents, Marketable securities, Gross Unrealized Gains	0	0
Cash and cash equivalents, Marketable securities, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	45
Cash and cash equivalents, Marketable securities, Estimated fair Value	132,552	139,986
Cash and cash equivalents	132,306	139,741	$ 123,365	$ 129,942
Marketable Security, Current	246	245
Bank Deposits [Member]
Schedule of Investments [Line Items]
Bank deposits, Cost	52,160	59,625
Bank deposits, Gross Unrealized Gains	0	0
Bank deposits, Gross Unrealized Losses	0	0
Bank deposits, Estimated fair Value	52,160	59,625
Cash and cash equivalents	52,160	59,625
Money market funds [Member]
Schedule of Investments [Line Items]
Marketable security, Amortized Cost	80,146	80,116
Marketable security, Gross Unrealized Gains	0	0
Marketable security, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	80,146	80,116
Cash and cash equivalents	80,146	80,116
Bank CDs [Member]
Schedule of Investments [Line Items]
Marketable security, Amortized Cost	246	245
Marketable security, Gross Unrealized Gains	0	0
Marketable security, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	246	245
Marketable Security, Current	246	245
Mutual Fund [Member]
Schedule of Investments [Line Items]
Marketable security, Amortized Cost	0	0
Marketable security, Gross Unrealized Gains	0	0
Marketable security, Gross Unrealized Losses	0	0
Marketable security, Estimated fair Value	0	0
Marketable Security, Current	$ 0	$ 0

Balance Sheet Account Detail 38

Balance Sheet Account Detail - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended		12 Months Ended
	Mar. 31, 2016	Mar. 31, 2015	Dec. 31, 2015
Schedule Of Investments In Marketable Securities [Line Items]
Securities in continuous unrealized loss position, period	longer than one year.
Depreciation expense	$ 200	$ 200
Intangible asset amortization expense	5,800	6,900
Impairment of intangible assets	$ 8,183		$ 8,183
Other Intangible Assets [Member]
Schedule Of Investments In Marketable Securities [Line Items]
Intangible asset amortization expense		14,000
FUSILEV [Member]
Schedule Of Investments In Marketable Securities [Line Items]
Impairment of intangible assets		$ 7,200

Balance Sheet Account Detail 39

Balance Sheet Account Detail - Schedule of Property and Equipment Net of Accumulated Depreciation (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	$ 7,681	$ 7,620
(Less): Accumulated depreciation	(6,871)	(6,702)
Property and equipment, net of accumulated depreciation	810	918
Computer hardware and software [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	3,824	3,785
Laboratory equipment [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	622	608
Office furniture [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	355	355
Leasehold improvements [Member]
Property, Plant and Equipment [Line Items]
Property and equipment, at cost	$ 2,880	$ 2,872

Balance Sheet Account Detail 40

Balance Sheet Account Detail - Components of Inventories (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Jan. 31, 2016	Dec. 31, 2015
Inventory [Line Items]
Raw materials	$ 1,782		$ 1,606
Work-in-process	7,457		4,228
Finished goods	839		1,498
(Less:) Non-current portion of inventories included within other assets	(6,923)		(3,156)
Inventories	$ 3,155		$ 4,176
ZEVALIN [Member]
Inventory [Line Items]
Work-in-process		$ 3,400

Balance Sheet Account Detail 41

Balance Sheet Account Detail - Prepaid Expenses (Details) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Prepaid operating expenses	$ 2,352	$ 3,507
Current portion of debt issuance costs	0	0
Prepaid expenses and other assets	2,352	3,507
Long-term Debt [Member] | Accounting Standards Update 2015-03 [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	2,000	2,200
Other Assets [Member] | Accounting Standards Update 2015-03 [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	$ (2,000)	$ (2,200)

Balance Sheet Account Detail 42

Balance Sheet Account Detail - Schedule of Other Receivables (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Income tax receivable	$ 754	$ 1,301
Insurance receivable	7,188	7,100
Mundipharma promissory note	2,347	2,215
CASI note - short term	1,500	0
Eagle service revenue and support costs	1,450	0
Research and development expenses - reimbursements due	1,617	1,699
Other miscellaneous receivables	319	257
Other receivables	$ 15,175	$ 12,572

Balance Sheet Account Detail 43

Balance Sheet Account Detail - Components of Intangible Assets Net of Accumulated Amortization (Detail) - USD ($) $ in Thousands	Mar. 10, 2016	May. 29, 2013	Mar. 31, 2016	Mar. 31, 2016	Mar. 31, 2015	Dec. 31, 2015
Product Rights [Line Items]
Historical Cost			$ 305,668	$ 305,668		$ 305,668
Accumulated Amortization			(109,166)	(109,166)		(102,797)
Foreign Currency Translation				(3,566)		(4,353)
Impairment				(8,183)		(8,183)
Net Amount			184,753	184,753		190,335
Ligand Pharmaceuticals Inc [Member]
Product Rights [Line Items]
Milestone payments	$ 6,000		6,000
MARQIBO IPR&D (NHL indication) [Member]
Product Rights [Line Items]
Historical Cost			17,600	17,600		17,600
Accumulated Amortization			0	0		0
Foreign Currency Translation				0		0
Impairment				0		0
Net Amount			17,600	17,600		17,600
EVOMELA distribution rights [Member]
Product Rights [Line Items]
Historical Cost			7,700	7,700		7,700
Accumulated Amortization			0	0		0
Foreign Currency Translation				0		0
Impairment				0		0
Net Amount			7,700	$ 7,700		7,700
Full Amortization Period (months)				156 months
Remaining Amortization Period (months)				156 months
BELEODAQ distribution rights [Member]
Product Rights [Line Items]
Historical Cost			25,000	$ 25,000		25,000
Accumulated Amortization			(3,281)	(3,281)		(2,812)
Foreign Currency Translation				0		0
Impairment				0		0
Net Amount			21,719	$ 21,719		22,188
Full Amortization Period (months)				160 months
Remaining Amortization Period (months)				139 months
MARQIBO distribution rights [Member]
Product Rights [Line Items]
Historical Cost			26,900	$ 26,900		26,900
Accumulated Amortization			(9,624)	(9,624)		(8,544)
Foreign Currency Translation				0		0
Impairment				0		0
Net Amount			17,276	$ 17,276		18,356
Full Amortization Period (months)				81 months
Remaining Amortization Period (months)				48 months
FOLOTYN distribution rights [Member]
Product Rights [Line Items]
Historical Cost			118,400	$ 118,400		118,400
Accumulated Amortization			(31,834)	(31,834)		(29,474)
Foreign Currency Translation				0		0
Impairment		$ (1,000)		0		0
Net Amount			86,566	$ 86,566		88,926
Full Amortization Period (months)				152 months
Remaining Amortization Period (months)				110 months
ZEVALIN distribution rights [Member] | United States [Member]
Product Rights [Line Items]
Historical Cost			41,900	$ 41,900		41,900
Accumulated Amortization			(31,477)	(31,477)		(30,608)
Foreign Currency Translation				0		0
Impairment				0		0
Net Amount			10,423	$ 10,423		11,292
Full Amortization Period (months)				123 months
Remaining Amortization Period (months)				36 months
ZEVALIN distribution rights [Member] | Ex-U.S. [Member]
Product Rights [Line Items]
Historical Cost			23,490	$ 23,490		23,490
Accumulated Amortization			(13,543)	(13,543)		(12,632)
Foreign Currency Translation				(3,566)		(4,353)
Impairment				0		0
Net Amount			6,381	$ 6,381		6,505
Full Amortization Period (months)				96 months
Remaining Amortization Period (months)				48 months
FUSILEV distribution rights [Member]
Product Rights [Line Items]
Historical Cost			16,778	$ 16,778		16,778
Accumulated Amortization			(9,618)	(9,618)		(9,618)
Foreign Currency Translation				0		0
Impairment				(7,160)		(7,160)
Net Amount			0	$ 0		0
Full Amortization Period (months)				56 months
Remaining Amortization Period (months)				0 months
FOLOTYN out-License [Member]
Product Rights [Line Items]
Historical Cost			27,900	$ 27,900		27,900
Accumulated Amortization			(9,789)	(9,789)		(9,109)
Foreign Currency Translation				0		0
Impairment				(1,023)		(1,023)
Net Amount			17,088	$ 17,088		$ 17,768
Full Amortization Period (months)				110 months
Remaining Amortization Period (months)				76 months
FUSILEV [Member]
Product Rights [Line Items]
Impairment					$ (7,200)
EVOMELA [Member]
Product Rights [Line Items]
Historical Cost			$ 7,700	$ 7,700

Balance Sheet Account Detail 44

Balance Sheet Account Detail - Estimated Intangible Asset Amortization Expense (Detail) $ in Thousands	Mar. 31, 2016USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Remainder of 2016	$ 18,017
2,017	24,023
2,018	24,023
2,019	21,417
2,020	16,113
2,021	14,634
2022 and thereafter	48,926
Intangible Assets, Net Total	$ 167,153

Balance Sheet Account Detail 45

Balance Sheet Account Detail - Schedule of Goodwill (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Goodwill [Line Items]
Foreign currency exchange translation effects	$ (353)	$ (437)
Goodwill	18,044	17,960
ZEVALIN Ex-U.S. Distribution Rights [Member]
Goodwill [Line Items]
Acquisition	2,525	2,525
Allos Therapeutics, Inc. [Member]
Goodwill [Line Items]
Acquisition	5,346	5,346
Talon [Member]
Goodwill [Line Items]
Acquisition	$ 10,526	$ 10,526

Balance Sheet Account Detail 46

Balance Sheet Account Detail - Summary of Other Assets (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Supplies and deposits	$ 1,165	$ 185
Equity securities - CASI (see Note 10)	7,520	6,689
2018 Convertible Notes issuance costs (excluding current portion)	0	0
Executive officer life insurance – cash surrender value	9,651	9,181
Inventories - non-current portion	6,923	3,156
Other miscellaneous assets	45	0
Other assets	25,304	19,211
Gross unrealized losses	1,400
Accounting Standards Update 2015-03 [Member] | Long-term Debt [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Debt issuance costs	2,000	$ 2,200
Zevalin [Member]
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Supplies and deposits	$ 1,000

Balance Sheet Account Detail 47

Balance Sheet Account Detail - Schedule of Accounts Payable and Other Accrued Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Trade accounts payable and other accrued liabilities	$ 31,922	$ 26,684
Accrued rebates	6,978	18,166
Accrued product royalty	4,076	4,908
Allowance for returns	1,429	1,394
Accrued data and distribution fees	1,126	1,830
Accrued GPO administrative fees	521	1,058
Accrued inventory management fee	210	498
Allowance for chargebacks	1,241	2,001
Accounts payable and other accrued liabilities	$ 47,503	$ 56,539

Balance Sheet Account Detail 48

Balance Sheet Account Detail - Schedule of Amounts Presented in Accounts Payable and Other Accrued Liabilities (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Rebates and Chargebacks [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	$ 20,167	$ 45,822
Add: provisions	19,952	75,498
(Less): credits or actual allowances	(31,900)	(101,153)
Ending balance	8,219	20,167
Data and Distribution, GPO Fees, and Inventory Management Fees [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	3,386	8,284
Add: provisions	2,227	15,928
(Less): credits or actual allowances	(3,755)	(20,826)
Ending balance	1,858	3,386
Returns [Member]
Accounts Payable and Other Liabilities [Roll Forward]
Beginning balance	1,394	1,135
Add: provisions	590	1,486
(Less): credits or actual allowances	(555)	(1,227)
Ending balance	$ 1,429	$ 1,394

Balance Sheet Account Detail 49

Balance Sheet Account Detail - Deferred Revenue (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Dec. 31, 2015	Sep. 30, 2015
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 2,908	$ 6,513
Mundipharma [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenue	2,472	0
FUSILEV [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenue	0	6,083	$ 9,900
Revenue recognized	6,100	3,800
Dr. Reddy
Deferred Revenue Arrangement [Line Items]
Deferred revenue	$ 436	$ 430

Balance Sheet Account Detail 50

Balance Sheet Account Detail - Summary of Other Long-Term Liabilities (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Accrued executive deferred compensation	$ 7,117	$ 6,458
Deferred rent (non-current portion)	235	248
Clinical study holdback costs, non-current	19	0
Other tax liabilities	738	738
Other long-term liabilities	$ 8,109	$ 7,444

Gross-to-Net Product Sales - Re

Gross-to-Net Product Sales - Reconciliation of Gross-to-Net Product Sales (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Revenue, Net [Abstract]
Gross product sales	$ 58,011	$ 62,598
Commercial rebates and government chargebacks	(19,953)	(18,144)
Data and distribution fees, GPO fees, and inventory management fees	(2,227)	(5,571)
Product returns allowance	(590)	(470)
Net product sales	$ 35,241	$ 38,413

Net Product Sales by Geograph52

Net Product Sales by Geographic Region and Product Line - Schedule of Product Sales, Net by Geography (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Sales Information [Line Items]
Product sales, net	$ 35,241	$ 38,413
Percentage of product sales, net	100.00%	100.00%
United States [Member]
Sales Information [Line Items]
Product sales, net	$ 33,779	$ 36,546
Percentage of product sales, net	95.90%	95.10%
Total International [Member]
Sales Information [Line Items]
Product sales, net	$ 1,462	$ 1,867
Percentage of product sales, net	4.10%	4.90%
Total International [Member] | Europe (ZEVALIN only) [Member]
Sales Information [Line Items]
Product sales, net	$ 1,462	$ 644
Percentage of product sales, net	4.10%	1.70%
Total International [Member] | Asia Pacific (ZEVALIN only)[Member]
Sales Information [Line Items]
Product sales, net	$ 0	$ 1,223
Percentage of product sales, net	0.00%	3.20%

Net Product Sales by Geograph53

Net Product Sales by Geographic Region and Product Line - Schedule of Product Sales, Net by Product Line (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Sales Information [Line Items]
Product sales, net	$ 35,241	$ 38,413
Percentage of product sales, net	100.00%	100.00%
FUSILEV [Member]
Sales Information [Line Items]
Product sales, net	$ 15,209	$ 20,167
FOLOTYN [Member]
Sales Information [Line Items]
Product sales, net	13,292	9,316
ZEVALIN [Member]
Sales Information [Line Items]
Product sales, net	2,783	4,223
MARQIBO [Member]
Sales Information [Line Items]
Product sales, net	929	1,893
BELEODAQ [Member]
Sales Information [Line Items]
Product sales, net	$ 3,028	$ 2,814
Sales [Member]
Sales Information [Line Items]
Percentage of product sales, net	100.00%	100.00%
Sales [Member] | FUSILEV [Member]
Sales Information [Line Items]
Percentage of product sales, net	43.20%	52.50%
Sales [Member] | FOLOTYN [Member]
Sales Information [Line Items]
Percentage of product sales, net	37.70%	24.30%
Sales [Member] | ZEVALIN [Member]
Sales Information [Line Items]
Percentage of product sales, net	7.90%	11.00%
Sales [Member] | MARQIBO [Member]
Sales Information [Line Items]
Percentage of product sales, net	2.60%	4.90%
Sales [Member] | BELEODAQ [Member]
Sales Information [Line Items]
Percentage of product sales, net	8.60%	7.30%

Stock-Based Compensation - Summ

Stock-Based Compensation - Summary of Stock-Based Compensation Expense (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	$ 3,177	$ 2,462
Cost of Sales [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	27	0
Research and development [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	381	433
Selling, general and administrative [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Total share-based compensation	$ 2,769	$ 2,029

Net Loss Per Share - Computatio

Net Loss Per Share - Computation of Net Loss Per Share (Detail) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Earnings Per Share [Abstract]
Net loss	$ (9,321)	$ (25,562)
Weighted average shares - basic and diluted (shares)	65,597,261	64,880,677
Net loss per share - basic and diluted ($ per share)	$ (0.14)	$ (0.39)

Net Loss Per Share - Schedule o

Net Loss Per Share - Schedule of Securities Excluded from Calculation of Net Loss Per Share (Detail) - shares	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	15,016,646	14,867,194
Preferred stock [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	40,000	40,000
Common stock warrants [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	0	71,227
2018 Convertible Notes [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	11,401,284	11,401,284
Common stock options [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	982,748	1,825,868
Restricted stock awards [Member]
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Anti-dilutive excluded from computation of earnings per share amount (shares)	2,592,614	1,528,815

Fair Value Measurements - Summa

Fair Value Measurements - Summary of Asset and Liability Fair Values (Detail) - USD ($) $ in Thousands	Mar. 31, 2016	Dec. 31, 2015
Assets:
Marketable securities, fair value	$ 45
Total Assets	97,608	$ 94,731
Liabilities:
Deferred executive compensation liability	7,117	6,458
Deferred drug development liability	14,510
Deferred drug development costs		14,686
Ligand Contingent Consideration	6,000	5,227
Talon CVR	1,646	1,377
Corixa Liability	62	62
Total Liabilities	29,335	27,810
Bank CDs [Member]
Assets:
Marketable securities, fair value	246	245
Money market currency funds [Member]
Assets:
Marketable securities, fair value	80,146	80,116
Equity securities [Member]
Assets:
Marketable securities, fair value	7,520	5,189
Notes Receivable [Member]
Assets:
Marketable securities, fair value	0
Deferred compensation investments, including life insurance cash surrender value [Member]
Assets:
Marketable securities, fair value	9,651	9,181
Level 1 [Member]
Assets:
Total Assets	7,520	5,189
Level 1 [Member] | Equity securities [Member]
Assets:
Marketable securities, fair value	7,520	5,189
Level 2 [Member]
Assets:
Marketable securities, fair value	45
Total Assets	90,088	89,542
Liabilities:
Deferred executive compensation liability	7,117	6,458
Total Liabilities	7,117	6,458
Level 2 [Member] | Bank CDs [Member]
Assets:
Marketable securities, fair value	246	245
Level 2 [Member] | Money market currency funds [Member]
Assets:
Marketable securities, fair value	80,146	80,116
Level 2 [Member] | Deferred compensation investments, including life insurance cash surrender value [Member]
Assets:
Marketable securities, fair value	9,651	9,181
Level 3 [Member]
Assets:
Total Assets	0	0
Liabilities:
Deferred drug development liability	14,510
Deferred drug development costs		14,686
Ligand Contingent Consideration	6,000	5,227
Talon CVR	1,646	1,377
Corixa Liability	62	62
Total Liabilities	22,218	$ 21,352
Level 3 [Member] | Notes Receivable [Member]
Assets:
Marketable securities, fair value	$ 0

Fair Value Measurements - Fair

Fair Value Measurements - Fair Value Measurement Activity for Liabilities Utilize Level 3 Inputs (Detail) - USD ($) $ in Thousands	3 Months Ended	12 Months Ended
	Mar. 31, 2016	Dec. 31, 2015
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Beginning Balance	$ 21,352	$ 23,127
Ending Balance	22,218	21,352
Deferred development costs [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Transfers in (out) of Level 3	(176)	(1,099)
Ligand Contingent Consideration [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Transfers in (out) of Level 3	773	326
Talon CVR [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Transfers in (out) of Level 3	269	(1,002)
Corixa Liability [Member]
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward]
Transfers in (out) of Level 3	$ 0	$ 0

Business Combinations and Con59

Business Combinations and Contingent Consideration - Additional Information (Detail) - USD ($) $ / shares in Units, shares in Millions	Mar. 10, 2016	Jul. 17, 2013	Sep. 05, 2012	Mar. 31, 2016	Mar. 31, 2013	Mar. 31, 2016	Dec. 31, 2015
Business Acquisition [Line Items]
License fees received					$ 3,000,000
Ligand Contingent Consideration				$ 6,000,000		$ 6,000,000	$ 5,227,000
Historical Cost				305,668,000		305,668,000	305,668,000
In-process research and development [Member]
Business Acquisition [Line Items]
Estimated cash flow period					10 years
Estimated cash flow discount rate					25.00%
Ligand Pharmaceuticals Inc [Member]
Business Acquisition [Line Items]
Milestone payments	$ 6,000,000			6,000,000
Melphalan In Process Research and Development [Member]
Business Acquisition [Line Items]
Historical Cost				$ 7,700,000		$ 7,700,000	$ 7,700,000
Minimum [Member]
Business Acquisition [Line Items]
Royalties payout percentage on our future net sales of licensed products				20.00%		20.00%
Milestone Payments [Member]
Business Acquisition [Line Items]
Milestone payments		$ 5,000,000				$ 66,000,000
Milestone net sales achievement		30,000,000
Ligand Contingent Consideration				$ 6,000,000		$ 6,000,000
Milestone Payment One [Member]
Business Acquisition [Line Items]
Milestone payments		10,000,000
Milestone net sales achievement		60,000,000
Milestone Payment Two [Member]
Business Acquisition [Line Items]
Milestone payments		25,000,000
Milestone net sales achievement		100,000,000
Milestone Payment Three [Member]
Business Acquisition [Line Items]
Milestone payments		50,000,000
Milestone net sales achievement		200,000,000
Milestone Payment Four [Member]
Business Acquisition [Line Items]
Milestone payments		100,000,000
Milestone net sales achievement		400,000,000
Menadione Topical Lotion [Member]
Business Acquisition [Line Items]
Milestone payments		5,000,000
Talon Therapeutics, Inc. [Member]
Business Acquisition [Line Items]
Additional shares business acquisition date						Jul. 17, 2013
Cash consideration		$ 11,300,000
Shares issued in acquisition (shares)		3
Common stock value assigned		$ 26,300,000
Common stock value, per share ($ per share)		$ 8.77
Estimated fair value of acquisition		$ 6,500,000
Contingent value rights future cash payments		$ 195,000,000		195,000,000		$ 195,000,000
Talon Therapeutics, Inc. [Member] | Minimum [Member]
Business Acquisition [Line Items]
Contingent value rights expected rate		50.00%
Talon Therapeutics, Inc. [Member] | Maximum [Member]
Business Acquisition [Line Items]
Contingent value rights expected rate		100.00%
Ligand Pharmaceuticals Inc [Member]
Business Acquisition [Line Items]
Ligand Contingent Consideration				$ 6,000,000		6,000,000
Change in contingent consideration						$ 800,000
Allos Therapeutics, Inc. [Member]
Business Acquisition [Line Items]
Cash consideration			$ 205,200,000

Business Combinations and Con60

Business Combinations and Contingent Consideration - Change in Fair Value of Contingent Consideration Related to Acquisitions (Detail) $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)
Talon Therapeutics, Inc. [Member]
Change in Fair Value of Contingent Consideration [Roll Forward]
December 31, 2015	$ 1,377
Fair value adjustment for the three months ended March 31, 2016	269
March 31, 2016	1,646
Ligand Pharmaceuticals Inc [Member]
Change in Fair Value of Contingent Consideration [Roll Forward]
December 31, 2015	5,227
Fair value adjustment for the three months ended March 31, 2016	773
March 31, 2016	$ 6,000

Business Combinations and Con61

Business Combinations and Contingent Consideration - Acquisition-Date Fair Value of Consideration Transferred (Detail) - Captisol-enabled, propylene glycol-free melphalan rights [Member] $ in Thousands	1 Months Ended
	Mar. 31, 2013USD ($)
Business Acquisition [Line Items]
Cash consideration	$ 3,000
Ligand Contingent Consideration	4,700
Total purchase consideration	$ 7,700

Business Combinations and Con62

Business Combinations and Contingent Consideration - Summary of Allocation of Total Purchase Price to Net Assets Acquired (Detail) - Captisol-enabled, propylene glycol-free melphalan rights [Member] - USD ($) $ in Thousands	Mar. 31, 2016	Mar. 31, 2013
Business Acquisition, Contingent Consideration [Line Items]
Total purchase consideration		$ 7,700
In-process research and development [Member]
Business Acquisition, Contingent Consideration [Line Items]
Total purchase consideration	$ 7,700

Out-License of Marqibo, Zeval63

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI - Additional Information (Detail) shares in Millions	Sep. 17, 2014productagreementshares	Feb. 29, 2016shares	Mar. 31, 2016	Mar. 31, 2016shares
Other Commitments [Line Items]
Shares received (shares)	5.4
CASI Out-License [Member]
Other Commitments [Line Items]
Number of agreements | agreement	3
Number of products | product	2
License agreement description			Additionally, under certain conditions which generally expire on September 17, 2019, we have a right to receive additional CASI common stock in order to maintain our post-investment ownership percentage if CASI issues additional securities.
Shares received (shares)	5.4	1.7		7.1

Out-License of Marqibo, Zeval64

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI - Schedule of Proceeds Received and Fair Value on CASI Out-License Execution Date (Detail) - CASI Out-License [Member] $ in Thousands	Sep. 17, 2014USD ($)
Other Commitments [Line Items]
Total consideration received	$ 9,959
Secured Promissory Note Due March 17, 2016 [Member]
Other Commitments [Line Items]
Total consideration received	1,310
Common Stock [Member]
Other Commitments [Line Items]
Total consideration received	$ 8,649

Out-License of Marqibo, Zeval65

Out-License of Marqibo, Zevalin, and Evolema in China Territory to CASI - Schedule of Proceeds Received and Fair Value on CASI Out-License Execution Date (Parenthetical) (Detail) - USD ($) $ / shares in Units, shares in Millions	Sep. 17, 2014	Feb. 29, 2016	Mar. 31, 2016	Mar. 31, 2016	Dec. 31, 2015
Other Commitments [Line Items]
Shares received (shares)	5.4
Debt instrument face value	$ 1,500,000
Fair value			$ 7,520,000	$ 7,520,000	$ 6,689,000
Secured Promissory Note Due March 17, 2016 [Member]
Other Commitments [Line Items]
Debt instrument face value	$ 1,500,000
CASI Out-License [Member]
Other Commitments [Line Items]
Shares received (shares)	5.4	1.7		7.1
Stock price on the NASDAQ Capital Market	$ 1.60
CASI Out-License [Member] | Secured Promissory Note Due March 17, 2016 [Member]
Other Commitments [Line Items]
Debt instrument maturity date			Mar. 17, 2016
Debt instrument coupon rate	0.50%
Common Stock [Member] | CASI Out-License [Member]
Other Commitments [Line Items]
Fair value			$ 7,500,000	$ 7,500,000

Out-License Of Zevalin In Cer66

Out-License Of Zevalin In Certain Ex-U.S. Territories To Mundipharma (Details) - USD ($) $ in Thousands	Nov. 16, 2015	Mar. 31, 2016	Dec. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue		$ 2,908	$ 6,513
Zevalin Rights [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential payment	$ 2,000
Zevalin Rights [Member] | Total Consideration [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	18,000
Milestone net sales achievement			$ 15,000
Zevalin Rights [Member] | Payment One [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	15,000
Zevalin Rights [Member] | Payment Two [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	3,000
Milestone net sales achievement		400
Deferred revenue		$ 2,500
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Payments for sale of business	$ (2,200)

Out-License Of Zevalin, Folot67

Out-License Of Zevalin, Folotyn, Beleodaq, And Marqibo In Canada Territory To Servier (Details) - USD ($) $ in Millions	Jan. 08, 2016	Jan. 31, 2016
ZEVALIN, FOLOTYN, BELEODAQ, And MARQIBO [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Total consideration received	$ 6	$ 6

Co-Promotion Arrangement With68

Co-Promotion Arrangement With Eagle Pharmaceuticals (Details) - Collaborative Arrangement, Co-promotion [Member] $ in Millions	Nov. 04, 2015USD ($)product	Mar. 31, 2016USD ($)	Jun. 30, 2017USD ($)	Dec. 31, 2016USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of products | product	6
Term of contract	18 months
Fixed payment	$ 12.8
Milestone net sales achievement		$ 1.9
Reimbursable expense		$ 1.3
Extension term	6 months
Termination notice	60 days
Maximum [Member] | Scenario, Forecast [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone net sales achievement			$ 4	$ 5

Convertible Senior Notes - Addi

Convertible Senior Notes - Additional Information (Detail) - USD ($)	Dec. 17, 2013	Mar. 31, 2016	Dec. 31, 2015
Debt Disclosure [Line Items]
Additional paid-in capital		$ 555,056,000	$ 552,108,000
Common shares sold (shares)		$ 68,000	68,000
2.75% Convertible Senior Notes Due 2018 [Member]
Debt Disclosure [Line Items]
Interest rate	2.75%	2.75%
Sale of convertible notes, principal amount	$ 120,000,000
Conversion rate, shares (shares)		95
Conversion rate, price per share ($ per share)		$ 1,000
Money conversion price per share ($ per share)		$ 10.53
Convertible senior notes maturity date		Dec. 15, 2018
Net proceeds from convertible notes	115,400,000
Professional fee	$ 4,600,000
Additional paid-in capital		$ 13,100,000
Common shares converted value (shares)		$ 11,400,000
Strike price per share ($ per share)		$ 14.03
Common shares sold (shares)		$ 11,400,000
Threshold percentage of conversion price		130.00%
Convertible senior notes trading price		$ 1,000
Percentage of product of last reported sale price of common stock		98.00%
Convertible senior notes conversion description		Prior to June 15, 2018, holders may convert all or a portion of their 2018 Convertible Notes only under any of the following circumstances: (1) during any fiscal quarter (and only during such fiscal quarter), if, for at least 20 trading days (whether or not consecutive) during the 30 consecutive trading day period ending on the last trading day of the immediately preceding fiscal quarter, the last reported sale price of our common stock on such trading day is greater than or equal to 130% of the Notes' conversion price on such trading day; (2) during the five consecutive business day period immediately following any five consecutive trading day period in which, for each trading day of that measurement period, the trading price per $1,000 principal amount of 2018 Convertible Notes for such trading day was less than 98% of the product of (i) the last reported sale price of our common stock on such trading day and (ii) the Notes' conversion rate on such trading day; (3) upon the occurrence of certain corporate transactions; and (4) at any time prior to our stockholders’ approval to settle the 2018 Convertible Notes in our common shares and/or cash.
2.75% Convertible Senior Notes Due 2018 [Member] | Minimum [Member]
Debt Disclosure [Line Items]
Debt convertible trading days		20 days
Debt convertible consecutive trading days		5 days
2.75% Convertible Senior Notes Due 2018 [Member] | Maximum [Member]
Debt Disclosure [Line Items]
Debt convertible consecutive trading days		30 days
2018 Convertible Notes [Member]
Debt Disclosure [Line Items]
Fair value		$ 106,600,000	$ 105,100,000

Convertible Senior Notes - Carr

Convertible Senior Notes - Carrying Value of 2018 Convertible Notes (Detail) - 2018 Convertible Notes [Member] $ in Thousands	Mar. 31, 2016USD ($)
Debt Instrument [Line Items]
Principal amount	$ 120,000
(Less): Unamortized debt discount (amortized through December 2018)	(17,067)
(Less): Debt issuance costs (see Note 3(d))	(2,000)
March 31, 2016 carrying value	$ 100,933

Convertible Senior Notes - Comp

Convertible Senior Notes - Components of the Interest Expense Recognized (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Debt Disclosure [Abstract]
Contractual coupon interest expense	$ 825
Amortization of debt issuance costs	171	$ 162
Accretion of debt discount	1,385	$ 1,270
Total	$ 2,381
Effective interest rate	8.66%

Mundipharma Agreement And Dru72

Mundipharma Agreement And Drug Development Liability - Additional Information (Detail) - USD ($) $ in Thousands	May. 29, 2013	Mar. 31, 2016	Mar. 31, 2015
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Company determined development payment		$ 50,149	$ 60,279
Mundipharma [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Company determined development payment	$ 7,000
Maximum [Member] | Regulatory [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments		16,000
Maximum [Member] | Commercial progress and sales-dependent [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Potential milestone payments		$ 107,000

Mundipharma Agreement And Dru73

Mundipharma Agreement And Drug Development Liability - Schedule of Drug Development Liability Adjustments (Detail) $ in Thousands	3 Months Ended
	Mar. 31, 2016USD ($)
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	$ 259
Balance at March 31, 2016	156
FOLOTYN [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	14,686
Transfer from long-term to current in 2016	0
(Less): Expenses incurred in 2016	(176)
Balance at March 31, 2016	14,510
FOLOTYN [Member] | Drug Development Liability Current [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	259
Transfer from long-term to current in 2016	74
(Less): Expenses incurred in 2016	(176)
Balance at March 31, 2016	157
FOLOTYN [Member] | Drug Development Liability Long Term [Member]
Accrued Drug Development Expenses [Roll Forward]
Balance at December 31, 2015	14,427
Transfer from long-term to current in 2016	(74)
(Less): Expenses incurred in 2016	0
Balance at March 31, 2016	$ 14,353

Commitments and Contingencies -

Commitments and Contingencies - Additional Information (Detail) € in Millions

Mar. 10, 2016USD ($)

Jan. 08, 2016USD ($)

Nov. 16, 2015USD ($)

Oct. 27, 2015USD ($)

Jun. 27, 2014USD ($)

Jun. 19, 2014defendantANDA

Mar. 31, 2016USD ($)

Jan. 31, 2016USD ($)

Feb. 28, 2014USD ($)

Apr. 30, 2012EUR (€)

Feb. 28, 2010USD ($)

Nov. 30, 2009USD ($)

Oct. 31, 2008USD ($)shares

Mar. 31, 2016USD ($)Countryshares

Dec. 31, 2015USD ($)

Mar. 31, 2014USD ($)

Jul. 31, 2014USD ($)

Jul. 17, 2013USD ($)

May. 31, 2006USD ($)

Long-term Purchase Commitment [Line Items]

Potential milestone achievement

$ 100,000

$ 100,000

$ 100,000

Deferred revenue

2,908,000

2,908,000

6,513,000

Amount receivable on approval of oral form of FUSILEV

$ 200,000

Additional license fees

66,000,000

Acquisition-related contingent obligations, less current portion

1,708,000

1,708,000

1,439,000

Consideration paid for the rights granted (shares)

$ 1,000,000

Deferrals and contributions

$ 7,100,000

$ 7,100,000

6,500,000

Settlement amount

$ 7,000,000

Legal fees

$ 200,000

FOLOTYN ANDA [Member]

Long-term Purchase Commitment [Line Items]

Number of defendants | defendant

5

Number of Abbreviated New Drug Applications | ANDA

4

FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Percentage of royalty on annual worldwide sales under condition one

8.00%

8.00%

Percentage of royalty on annual worldwide sales under condition two

9.00%

9.00%

Percentage of royalty on annual worldwide sales under condition three

11.00%

11.00%

Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Potential payment

$ 2,000,000

ZEVALIN, FOLOTYN, BELEODAQ, And MARQIBO [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

$ 6,000,000

$ 6,000,000

Total Consideration [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

18,000,000

Milestone net sales achievement

15,000,000

Payment One [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

15,000,000

Payment Two [Member] | Zevalin Rights [Member]

Long-term Purchase Commitment [Line Items]

Total consideration received

$ 3,000,000

Milestone net sales achievement

$ 400,000

Deferred revenue

$ 2,500,000

2,500,000

Ligand Pharmaceuticals Inc [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 6,000,000

6,000,000

ZEVALIN [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 5,000,000

ZEVALIN [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

Minimum number of countries outside U.S. approved ZEVALIN for treatment | Country

40

Fees paid to Bayer for acquiring licensing rights | €

€ 19

License Agreement Contractual Terms

15 years

Percentage Of Royalty

20.00%

Talon Therapeutics, Inc. [Member]

Long-term Purchase Commitment [Line Items]

Acquisition-related contingent obligations, less current portion

1,600,000

$ 1,600,000

1,400,000

Contingent value rights future cash payments

195,000,000

195,000,000

$ 195,000,000

SPI-2012 [Member]

Long-term Purchase Commitment [Line Items]

Milestone payments

$ 1,900,000

Issuance (shares) | shares

318,750

Potential milestone achievement

$ 238,000,000

$ 238,000,000

Poziotinib [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

Milestone net sales achievement

$ 358,000,000

Minimum [Member]

Long-term Purchase Commitment [Line Items]

Percentage of royalty on annual worldwide sales under condition one

20.00%

20.00%

Percentage of royalties on net sale of licensed products

20.00%

Minimum [Member] | FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Amount of annual worldwide sales on which royalty is payable under condition two

$ 150,000,000

Amount of annual worldwide sales on which royalty is payable under condition three

300,000,000

Maximum [Member]

Long-term Purchase Commitment [Line Items]

Acquisition-related contingent obligations, less current portion

$ 6,000,000

6,000,000

$ 5,200,000

Maximum [Member] | FOLOTYN [Member]

Long-term Purchase Commitment [Line Items]

Amount of annual worldwide sales on which royalty is payable under condition one

150,000,000

Amount of annual worldwide sales on which royalty is payable under condition two

$ 300,000,000

INDIA | ZEVALIN [Member] | Licensing Agreements [Member]

Long-term Purchase Commitment [Line Items]

License Agreement Contractual Terms

15 years

Up-front non-refundable payment

$ 500,000

Recognition period for upfront payment

10 years

Licenses Revenue

$ 3,000,000

Percentage Of Royalty

20.00%

Allergan [Member]

Long-term Purchase Commitment [Line Items]

Up-front non-refundable payment

$ 41,500,000

License fee

$ 300,000

Allergan [Member] | Common Class A

Long-term Purchase Commitment [Line Items]

Common stock issued (shares) | shares

25,000

Stock issued

$ 100,000

Nippon Kayaku [Member]

Long-term Purchase Commitment [Line Items]

Upfront fee

$ 15,000,000

Payment related to agreement

$ 10,000,000

Payment on achievement of commercialization milestones

126,000,000

TopoTarget [Member]

Long-term Purchase Commitment [Line Items]

Potential milestone achievement

$ 278,000,000

$ 278,000,000

Upfront fee

$ 30,000,000

Percentage of development cost

70.00%

Percentage of development cost that is funded by TopoTarget for joint development plan

30.00%

Additional payments based on the achievement of certain development

$ 10,000,000

Aggregate payout value

$ 17,800,000

Second milestone payment

$ 25,000,000

Principal executive office [Member] | Nevada [Member]

Long-term Purchase Commitment [Line Items]

Facility lease, non-cancelable operating lease expiring date

Apr. 30, 2019

Research and development facility [Member] | California [Member]

Long-term Purchase Commitment [Line Items]

Facility lease, non-cancelable operating lease expiring date

May 31, 2019

Income Taxes - Additional Infor

Income Taxes - Additional Information (Detail) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2016	Mar. 31, 2015
Income Tax Disclosure [Abstract]
Provision for income taxes	$ (66)	$ 138
U.S. federal statutory tax rate	35.00%