EXHIBIT 31.1
CERTIFICATION OF PRINCIPAL EXECUTIVE OFFICER
I, Rajesh C. Shrotriya, certify that:
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| 1. | I have reviewed this Annual Report on Form 10-K/A of Spectrum Pharmaceuticals, Inc.; and |
| 2. | Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
Date: June 10, 2016
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| /s/ RAJESH C. SHROTRIYA |
| Rajesh C. Shrotriya, M.D. |
| Chairman and Chief Executive Officer |
| (Principal Executive Officer) |
